RU2014136560A - Method of neutron-photon therapy for patients with breast cancer - Google Patents

Method of neutron-photon therapy for patients with breast cancer Download PDF

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Publication number
RU2014136560A
RU2014136560A RU2014136560A RU2014136560A RU2014136560A RU 2014136560 A RU2014136560 A RU 2014136560A RU 2014136560 A RU2014136560 A RU 2014136560A RU 2014136560 A RU2014136560 A RU 2014136560A RU 2014136560 A RU2014136560 A RU 2014136560A
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Russia
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neutron
sod
bolus
daily
patients
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RU2014136560A
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Russian (ru)
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RU2582214C2 (en
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Юрий Станиславович Мардынский
Игорь Александрович Гулидов
Алексей Сергеевич Сысоев
Степан Евгеньевич Ульяненко
Гамзат Гашимович Аминов
Владимир Иванович Потетня
Сергей Николаевич Корякин
Юрий Александрович Рагулин
Николай Григорьевич Горбушин
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Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России)
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Priority to RU2014136560/14A priority Critical patent/RU2582214C2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy
    • A61N5/103—Treatment planning systems
    • A61N5/1031—Treatment planning systems using a specific method of dose optimization

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiation-Therapy Devices (AREA)

Abstract

1. Способ нейтронно-фотонной терапии больных раком молочной железы, включающий сочетанную нейтронно-фотонную терапию, отличающийся тем, что вначале размещают болюс на облучаемую молочную железу и изменяют конфигурацию органа, обеспечивающую формирование оптимального распределения дозы облучения в опухоли, при этом облучение нейтронами проводят в режиме от 0,2 до 0,4 Гр, ежедневно до СОД 2,0 Гр или по 1,0 Гр в течение 3 сеансов до СОД 3,0 Гр, а затем проводят гамма-облучение ежедневно от 1,0 до 2,0 Гр до СОД 45-50 Гр.2. Способ по п. 1, отличающийся тем, что болюс изготавливают из тканеэквивалентного материала в виде прозрачных пластин с возможностью изменения и фиксации расстояния между ними.3. Способ по п. 1, отличающийся тем, что при планировании лечения оптимальный вклад нейтронной компоненты с учетом ОБЭ в суммарном курсе сочетанной терапии выбирают от 17 до 30%.1. The method of neutron-photon therapy for patients with breast cancer, including combined neutron-photon therapy, characterized in that the bolus is first placed on the irradiated mammary gland and the organ configuration is changed, which ensures the formation of an optimal radiation dose distribution in the tumor, while neutron irradiation is carried out in mode from 0.2 to 0.4 Gy, daily to SOD 2.0 Gy or 1.0 Gy for 3 sessions to SOD 3.0 Gy, and then gamma irradiation daily from 1.0 to 2.0 Gy to SOD 45-50 Gy. 2. A method according to claim 1, characterized in that the bolus is made of tissue-equivalent material in the form of transparent plates with the possibility of changing and fixing the distance between them. The method according to claim 1, characterized in that when planning treatment, the optimal contribution of the neutron component, taking into account RBE in the total course of combination therapy, is selected from 17 to 30%.

Claims (3)

1. Способ нейтронно-фотонной терапии больных раком молочной железы, включающий сочетанную нейтронно-фотонную терапию, отличающийся тем, что вначале размещают болюс на облучаемую молочную железу и изменяют конфигурацию органа, обеспечивающую формирование оптимального распределения дозы облучения в опухоли, при этом облучение нейтронами проводят в режиме от 0,2 до 0,4 Гр, ежедневно до СОД 2,0 Гр или по 1,0 Гр в течение 3 сеансов до СОД 3,0 Гр, а затем проводят гамма-облучение ежедневно от 1,0 до 2,0 Гр до СОД 45-50 Гр.1. The method of neutron-photon therapy for patients with breast cancer, including combined neutron-photon therapy, characterized in that the bolus is first placed on the irradiated mammary gland and the organ configuration is changed, which ensures the formation of an optimal radiation dose distribution in the tumor, while neutron irradiation is carried out in mode from 0.2 to 0.4 Gy, daily to SOD 2.0 Gy or 1.0 Gy for 3 sessions to SOD 3.0 Gy, and then gamma irradiation daily from 1.0 to 2.0 Gy to SOD 45-50 Gy. 2. Способ по п. 1, отличающийся тем, что болюс изготавливают из тканеэквивалентного материала в виде прозрачных пластин с возможностью изменения и фиксации расстояния между ними.2. The method according to p. 1, characterized in that the bolus is made of tissue-equivalent material in the form of transparent plates with the ability to change and fix the distance between them. 3. Способ по п. 1, отличающийся тем, что при планировании лечения оптимальный вклад нейтронной компоненты с учетом ОБЭ в суммарном курсе сочетанной терапии выбирают от 17 до 30%. 3. The method according to p. 1, characterized in that when planning treatment, the optimal contribution of the neutron component, taking into account RBE in the total course of combination therapy, is selected from 17 to 30%.
RU2014136560/14A 2014-09-09 2014-09-09 Method for neutron-photon therapy of breast cancer patients RU2582214C2 (en)

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RU2582214C2 RU2582214C2 (en) 2016-04-20

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2186591C2 (en) * 1997-02-04 2002-08-10 Научно-исследовательский институт онкологии Томского научного центра СО РАМН Method for neutron-photon therapy of locally spread mammary gland cancer
US8036435B2 (en) * 2007-09-28 2011-10-11 Varian Medical Systems, Inc. Cancer detection, diagnosis, staging, treatment planning, delivery, and monitoring using X-ray attenuation coefficient distributions

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