RU2018119194A - Фармацевтические композиции, содержащие амид леводопы, и их применения - Google Patents
Фармацевтические композиции, содержащие амид леводопы, и их применения Download PDFInfo
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- RU2018119194A RU2018119194A RU2018119194A RU2018119194A RU2018119194A RU 2018119194 A RU2018119194 A RU 2018119194A RU 2018119194 A RU2018119194 A RU 2018119194A RU 2018119194 A RU2018119194 A RU 2018119194A RU 2018119194 A RU2018119194 A RU 2018119194A
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- 239000008194 pharmaceutical composition Substances 0.000 title claims 51
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 title claims 4
- 229960004502 levodopa Drugs 0.000 title claims 4
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 title 1
- 239000000872 buffer Substances 0.000 claims 39
- 150000003839 salts Chemical class 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 14
- 239000002899 monoamine oxidase inhibitor Substances 0.000 claims 14
- 229940123736 Decarboxylase inhibitor Drugs 0.000 claims 13
- 239000003954 decarboxylase inhibitor Substances 0.000 claims 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 12
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 11
- 150000002337 glycosamines Chemical class 0.000 claims 11
- 229940123685 Monoamine oxidase inhibitor Drugs 0.000 claims 10
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- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 6
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- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
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- 229940098779 methanesulfonic acid Drugs 0.000 claims 1
- 150000007522 mineralic acids Chemical class 0.000 claims 1
- 230000000926 neurological effect Effects 0.000 claims 1
- 201000005040 opiate dependence Diseases 0.000 claims 1
- 150000007524 organic acids Chemical class 0.000 claims 1
- 235000006408 oxalic acid Nutrition 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 239000001384 succinic acid Substances 0.000 claims 1
- 235000011044 succinic acid Nutrition 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
- 239000011975 tartaric acid Substances 0.000 claims 1
- 235000002906 tartaric acid Nutrition 0.000 claims 1
Classifications
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
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- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Biochemistry (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201562259324P | 2015-11-24 | 2015-11-24 | |
| US62/259,324 | 2015-11-24 | ||
| PCT/IL2016/051261 WO2017090039A2 (en) | 2015-11-24 | 2016-11-23 | Pharmaceutical compositions comprising levodopa amide and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018119194A true RU2018119194A (ru) | 2019-12-25 |
| RU2018119194A3 RU2018119194A3 (https=) | 2020-04-20 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2018119194A RU2018119194A (ru) | 2015-11-24 | 2016-11-23 | Фармацевтические композиции, содержащие амид леводопы, и их применения |
Country Status (13)
| Country | Link |
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| US (1) | US20170296491A1 (https=) |
| EP (1) | EP3380076A2 (https=) |
| JP (1) | JP2018535230A (https=) |
| CN (1) | CN108495617A (https=) |
| AU (1) | AU2016358511A1 (https=) |
| BR (1) | BR112018010564A2 (https=) |
| CA (1) | CA3006028A1 (https=) |
| CL (1) | CL2018001395A1 (https=) |
| IL (1) | IL259484A (https=) |
| RU (1) | RU2018119194A (https=) |
| SG (1) | SG11201804395PA (https=) |
| WO (1) | WO2017090039A2 (https=) |
| ZA (1) | ZA201803485B (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3116475T3 (da) | 2014-03-13 | 2020-12-07 | Neuroderm Ltd | Dopa-decarboxylasehæmmersammensætninger |
| US10258585B2 (en) | 2014-03-13 | 2019-04-16 | Neuroderm, Ltd. | DOPA decarboxylase inhibitor compositions |
| WO2019038638A1 (en) | 2017-08-21 | 2019-02-28 | Neuroderm Ltd | PROCESS FOR PREPARING AMIDE OF PURIFIED LEVODOPA |
| AR112472A1 (es) | 2017-08-21 | 2019-10-30 | Neuroderm Ltd | Forma de sales cristalinas de amida de levodopa y métodos para elaborarlas y usarlas |
| AR112683A1 (es) | 2017-08-21 | 2019-11-27 | Neuroderm Ltd | Forma cristalina de base libre de levodopa, su sal de adición y composición farmaceutica que la comprende |
| WO2019145773A1 (en) | 2017-12-15 | 2019-08-01 | Nos Life Sciences Corporation | Liposomal-encapsulated formulations |
| WO2020178810A1 (en) * | 2019-03-04 | 2020-09-10 | Neuroderm, Ltd. | Pharmaceutical compositions comprising levodopa amide derivatives and uses thereof |
| CN113924086A (zh) * | 2019-04-17 | 2022-01-11 | 维奇健康科学有限责任公司 | 液体药物组合物 |
| PH12022550512A1 (en) * | 2019-09-05 | 2023-09-04 | Neuroderm Ltd | Liquid compositions comprising a levodopa amino acid conjugate and uses thereof |
| JP7506371B2 (ja) * | 2020-01-20 | 2024-06-26 | 国立大学法人浜松医科大学 | ドーパミン減少抑制剤 |
| US11213502B1 (en) | 2020-11-17 | 2022-01-04 | Neuroderm, Ltd. | Method for treatment of parkinson's disease |
| US11331293B1 (en) | 2020-11-17 | 2022-05-17 | Neuroderm, Ltd. | Method for treatment of Parkinson's disease |
| US11844754B2 (en) | 2020-11-17 | 2023-12-19 | Neuroderm, Ltd. | Methods for treatment of Parkinson's disease |
| CN116270675A (zh) * | 2023-03-21 | 2023-06-23 | 山东省分析测试中心 | N-乙酰氨基葡萄糖在防治mptp诱导神经元损伤中的应用 |
| US12161612B2 (en) | 2023-04-14 | 2024-12-10 | Neuroderm, Ltd. | Methods and compositions for reducing symptoms of Parkinson's disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2004069146A2 (en) * | 2003-02-07 | 2004-08-19 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | L-dopa amide derivatives and uses thereof |
| PL2432454T3 (pl) | 2009-05-19 | 2017-10-31 | Neuroderm Ltd | Kompozycje do ciągłego podawania inhibitorów dopa-dekarboksylazy |
| WO2012079072A2 (en) * | 2010-12-10 | 2012-06-14 | Synagile Corporation | Subcutaneously infusible levodopa prodrug compositions and methods of infusion |
| WO2013184646A2 (en) * | 2012-06-05 | 2013-12-12 | Synagile Corporation | Dosing regimens for subcutaneously infusible acidic compositions |
-
2016
- 2016-11-23 CN CN201680079822.0A patent/CN108495617A/zh not_active Withdrawn
- 2016-11-23 AU AU2016358511A patent/AU2016358511A1/en not_active Abandoned
- 2016-11-23 EP EP16816418.4A patent/EP3380076A2/en not_active Withdrawn
- 2016-11-23 JP JP2018526784A patent/JP2018535230A/ja active Pending
- 2016-11-23 BR BR112018010564-3A patent/BR112018010564A2/pt not_active IP Right Cessation
- 2016-11-23 CA CA3006028A patent/CA3006028A1/en not_active Abandoned
- 2016-11-23 US US15/360,165 patent/US20170296491A1/en not_active Abandoned
- 2016-11-23 RU RU2018119194A patent/RU2018119194A/ru not_active Application Discontinuation
- 2016-11-23 WO PCT/IL2016/051261 patent/WO2017090039A2/en not_active Ceased
- 2016-11-23 SG SG11201804395PA patent/SG11201804395PA/en unknown
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2018
- 2018-05-21 IL IL259484A patent/IL259484A/en unknown
- 2018-05-24 CL CL2018001395A patent/CL2018001395A1/es unknown
- 2018-05-25 ZA ZA2018/03485A patent/ZA201803485B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2018535230A (ja) | 2018-11-29 |
| WO2017090039A2 (en) | 2017-06-01 |
| EP3380076A2 (en) | 2018-10-03 |
| SG11201804395PA (en) | 2018-06-28 |
| US20170296491A1 (en) | 2017-10-19 |
| WO2017090039A3 (en) | 2017-08-31 |
| BR112018010564A2 (pt) | 2018-11-21 |
| CA3006028A1 (en) | 2017-06-01 |
| CL2018001395A1 (es) | 2018-10-12 |
| ZA201803485B (en) | 2019-08-28 |
| CN108495617A (zh) | 2018-09-04 |
| AU2016358511A1 (en) | 2018-06-21 |
| RU2018119194A3 (https=) | 2020-04-20 |
| IL259484A (en) | 2018-07-31 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200924 |