RU2017145068A - COMPOSITION ON THE BASIS OF BROMELEIN AND BACTERIA LIZATE FOR PREVENTION OF ORAL CAVITY DISEASES - Google Patents

COMPOSITION ON THE BASIS OF BROMELEIN AND BACTERIA LIZATE FOR PREVENTION OF ORAL CAVITY DISEASES Download PDF

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RU2017145068A
RU2017145068A RU2017145068A RU2017145068A RU2017145068A RU 2017145068 A RU2017145068 A RU 2017145068A RU 2017145068 A RU2017145068 A RU 2017145068A RU 2017145068 A RU2017145068 A RU 2017145068A RU 2017145068 A RU2017145068 A RU 2017145068A
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Russia
Prior art keywords
composition according
lysate
bacteria
oral cavity
hydroxyapatite
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RU2017145068A
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Russian (ru)
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RU2017145068A3 (en
RU2748594C2 (en
Inventor
Светлана Анатольевна ЗАКИРОВА
Павел Павлович Несмиянов
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Общество с ограниченной ответственностью "СПЛАТ-КОСМЕТИКА"
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Priority to RU2017145068A priority Critical patent/RU2748594C2/en
Priority to PCT/RU2018/000213 priority patent/WO2019125204A1/en
Publication of RU2017145068A3 publication Critical patent/RU2017145068A3/ru
Publication of RU2017145068A publication Critical patent/RU2017145068A/en
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Publication of RU2748594C2 publication Critical patent/RU2748594C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/742—Spore-forming bacteria, e.g. Bacillus coagulans, Bacillus subtilis, clostridium or Lactobacillus sporogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/745—Bifidobacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4873—Cysteine endopeptidases (3.4.22), e.g. stem bromelain, papain, ficin, cathepsin H
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A61Q11/02—Preparations for deodorising, bleaching or disinfecting dentures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22032—Stem bromelain (3.4.22.32)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/22—Cysteine endopeptidases (3.4.22)
    • C12Y304/22033—Fruit bromelain (3.4.22.33), i.e. juice bromelain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals

Claims (18)

1. Композиция для применения в полости рта, содержащая комбинацию протеолитического фермента бромелаина и лизата бактерий.1. Composition for use in the oral cavity, containing a combination of a proteolytic enzyme bromelain and a lysate of bacteria. 2. Композиция по п. 1, в которой лизат бактерий представляет собой лизат бифидобактерий.2. The composition according to claim 1, in which the lysate of bacteria is a lysate of bifidobacteria. 3. Композиция по п. 2, в которой лизат бифидобактерий представляет собой лизат Bifidobacterium longum, Bifidobacterium bifidum и Bifidobacterium adolescentis.3. The composition according to claim 2, wherein the lysate of bifidobacteria is a lysate of Bifidobacterium longum, Bifidobacterium bifidum and Bifidobacterium adolescentis. 4. Композиция по п. 1, в которой лизат бактерий представляет собой лизат Lactobacillus casei, Streptococcus mutans, Streptococcus sanguinis, Veillonella parvula и Candida albicans.4. The composition according to claim 1, wherein the bacterial lysate is the lactate of Lactobacillus casei, Streptococcus mutans, Streptococcus sanguinis, Veillonella parvula and Candida albicans. 5. Композиция по п. 1, в которой лизат бактерий представляет собой лизат Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus bulgaricus и Str. Thermophilus5. The composition according to claim 1, wherein the bacterial lysate is a lactate of Lactobacillus acidophilus, Lactobacillus fermentum, Lactobacillus bulgaricus and Str. Thermophilus 6. Композиция по п. 1, содержащая 0,005-0,2% мас. протеолитического фермента бромелаина.6. The composition according to claim 1, containing 0.005-0.2% wt. proteolytic enzyme bromelain. 7. Композиция по п. 1, содержащая 0,05-1,5% мас. лизата бактерий.7. The composition according to claim 1, containing 0.05-1.5% wt. lysate bacteria. 8. Композиция по п. 1, дополнительно содержащая усилитель очищающей способности.8. The composition according to claim 1, further comprising an amplifier of cleaning ability. 9. Композиция по п. 8, в которой усилитель очищающей способности выбран из группы: силика (диоксид кремния), карбонат кальция, дикальция фосфат дигидрат, кальция пирофосфат, оксид алюминия, перлит, бикарбонат натрия, древесный уголь, перекись водорода, кальция пероксид, цитрат натрия, пирофосфат натрия, триполифосфат натрия, гексаметафосфат натрия, кальция пероксид.9. The composition according to p. 8, in which the amplifier cleaning ability is selected from the group: silica (silica), calcium carbonate, dicalcium phosphate dihydrate, calcium pyrophosphate, aluminum oxide, perlite, sodium bicarbonate, charcoal, hydrogen peroxide, calcium peroxide, sodium citrate, sodium pyrophosphate, sodium tripolyphosphate, sodium hexametaphosphate, calcium peroxide. 10. Композиция по п. 1, дополнительно содержащая гидроксиапатит.10. The composition according to claim 1, further comprising hydroxyapatite. 11. Композиция по п. 10, в которой гидроксиапатит обогащен элементами, выбранными из группы: кальций, магний, цинк.11. The composition according to claim 10, in which hydroxyapatite is enriched with elements selected from the group of: calcium, magnesium, zinc. 12. Композиция по п. 1, дополнительно содержащая пленкообразующий компонент.12. The composition according to claim 1, further comprising a film-forming component. 13. Композиция по п. 12, в которой пленкообразующий компонент выбран из группы: поливинилпирролидон, поливиниловый спирт, воскоподобные вещества и их смеси.13. The composition according to claim 12, in which the film-forming component is selected from the group: polyvinylpyrrolidone, polyvinyl alcohol, wax-like substances, and mixtures thereof. 14. Композиция по п. 1, дополнительно содержащая пленкообразователь, усилитель очищающей способности, гидроксиапатит и вспомогательные вещества, % мас.:14. The composition according to claim 1, further comprising a film former, an amplifier of cleaning ability, hydroxyapatite and auxiliary substances,% by weight: протеолитический фермент бромелаинproteolytic enzyme bromelain 0,005-0,2,0.005-0.2, лизат бактерийbacteria lysate 0,05-1,5,0.05-1.5, пленкообразовательfilm former 0,3-1,0,0.3-1.0, усилитель очищающей способностиpower booster 2,5-5,0,2.5-5.0, гидроксиапатитhydroxyapatite 0,1-10,0,0.1-10.0, вспомогательные веществаExcipients до 100.up to 100.
15. Композиция по п. 1 для применения в полости рта для лечения заболеваний зубов, десен и/или полости рта.15. The composition according to claim 1 for use in the oral cavity for the treatment of diseases of the teeth, gums and / or oral cavity. 16. Композиция по п. 15, где указанные заболевания выбраны из гингивита, пародонтита, глоссита, стоматита, кариеса, ксеростомии, постравматических воспалений, вызванных ортодонтическими конструкциями.16. The composition according to p. 15, where these diseases are selected from gingivitis, periodontitis, glossitis, stomatitis, caries, xerostomia, post-traumatic inflammation caused by orthodontic structures. 17. Композиция по п. 1, находящаяся в форме зубной пасты, геля, спрея, жевательной резинки, пенки, эликсира, мази, бальзама или ополаскивателя.17. The composition according to claim 1, which is in the form of toothpaste, gel, spray, chewing gum, foam, elixir, ointment, balsam or rinse.
RU2017145068A 2017-12-21 2017-12-21 Composition based on bromelain and bacterial lysate for prevention of oral diseases RU2748594C2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
RU2017145068A RU2748594C2 (en) 2017-12-21 2017-12-21 Composition based on bromelain and bacterial lysate for prevention of oral diseases
PCT/RU2018/000213 WO2019125204A1 (en) 2017-12-21 2018-04-02 Composition based on bromelain and bacterial lysate for preventative treatment of oral diseases

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Application Number Priority Date Filing Date Title
RU2017145068A RU2748594C2 (en) 2017-12-21 2017-12-21 Composition based on bromelain and bacterial lysate for prevention of oral diseases

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RU2017145068A3 RU2017145068A3 (en) 2019-06-21
RU2017145068A true RU2017145068A (en) 2019-06-21
RU2748594C2 RU2748594C2 (en) 2021-05-27

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WO2021025584A2 (en) * 2019-08-08 2021-02-11 Общество С Ограниченной Ответственности "Сплат Глобал" Fullerene-containing agents for comprehensive care of the oral cavity

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JP2004250374A (en) * 2003-02-20 2004-09-09 Nippon Zettoc Co Ltd Composition for oral cavity
DE202009011379U1 (en) * 2009-08-24 2010-12-30 Khalifa, Samir Oral preparations for oral and dental care and combating halitosis
RU2416391C1 (en) * 2009-09-03 2011-04-20 Общество с ограниченной ответственностью "СПЛАТ-КОСМЕТИКА" Composition for oral cavity care
RU2496468C2 (en) * 2012-01-11 2013-10-27 Владимир Николаевич Иванов Tooth paste containing mixed bacterial lysate
RU2494724C2 (en) * 2012-01-13 2013-10-10 Владимир Николаевич Иванов Toothpaste, containing freeze-dried mass of live bifidobacteria
GB201206599D0 (en) * 2012-04-13 2012-05-30 Univ Manchester Probiotic bacteria
RU2535045C1 (en) * 2013-07-02 2014-12-10 Владимир Николаевич Иванов Tooth paste containing regeneration stimulators

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RU2748594C2 (en) 2021-05-27
WO2019125204A1 (en) 2019-06-27

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