RU2017142779A - Перенос гена cmlck - Google Patents
Перенос гена cmlck Download PDFInfo
- Publication number
- RU2017142779A RU2017142779A RU2017142779A RU2017142779A RU2017142779A RU 2017142779 A RU2017142779 A RU 2017142779A RU 2017142779 A RU2017142779 A RU 2017142779A RU 2017142779 A RU2017142779 A RU 2017142779A RU 2017142779 A RU2017142779 A RU 2017142779A
- Authority
- RU
- Russia
- Prior art keywords
- subject
- left ventricle
- polynucleotide vector
- heart
- amount
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title claims 5
- 238000000034 method Methods 0.000 claims 18
- 102000040430 polynucleotide Human genes 0.000 claims 6
- 108091033319 polynucleotide Proteins 0.000 claims 6
- 239000002157 polynucleotide Substances 0.000 claims 6
- 239000013598 vector Substances 0.000 claims 6
- 210000005240 left ventricle Anatomy 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 206010019280 Heart failures Diseases 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 102400001263 NT-proBNP Human genes 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 230000003205 diastolic effect Effects 0.000 claims 1
- 239000002934 diuretic Substances 0.000 claims 1
- 210000002064 heart cell Anatomy 0.000 claims 1
- 238000001802 infusion Methods 0.000 claims 1
- 239000002502 liposome Substances 0.000 claims 1
- 230000001452 natriuretic effect Effects 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 108010008064 pro-brain natriuretic peptide (1-76) Proteins 0.000 claims 1
- 230000000750 progressive effect Effects 0.000 claims 1
- 230000002861 ventricular Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/45—Transferases (2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/11—Protein-serine/threonine kinases (2.7.11)
- C12Y207/11018—Myosin-light-chain kinase (2.7.11.18)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Cardiology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Hospice & Palliative Care (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNCN201510232415.6 | 2015-05-08 | ||
| CN201510232415.6A CN106177992A (zh) | 2015-05-08 | 2015-05-08 | cMLCK基因导入 |
| PCT/CN2016/085699 WO2016180377A1 (zh) | 2015-05-08 | 2016-06-14 | cMLCK基因导入 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017142779A true RU2017142779A (ru) | 2019-06-10 |
| RU2017142779A3 RU2017142779A3 (https=) | 2019-12-03 |
Family
ID=57247711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017142779A RU2017142779A (ru) | 2015-05-08 | 2016-06-14 | Перенос гена cmlck |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20180133291A1 (https=) |
| EP (1) | EP3295959A4 (https=) |
| JP (1) | JP2018515510A (https=) |
| KR (1) | KR20190008511A (https=) |
| CN (3) | CN106177992A (https=) |
| AU (1) | AU2016260473A1 (https=) |
| BR (1) | BR112017024065A2 (https=) |
| CA (1) | CA2985396A1 (https=) |
| RU (1) | RU2017142779A (https=) |
| WO (1) | WO2016180377A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013053076A1 (en) | 2011-10-10 | 2013-04-18 | Zensun （Shanghai）Science & Technology Limited | Compositions and methods for treating heart failure |
| AU2012392119B2 (en) | 2012-10-08 | 2018-07-26 | Zensun (Shanghai) Science & Technology, Co. Ltd. | Compositions and methods for treating heart failure in diabetic patients |
| CN106177992A (zh) * | 2015-05-08 | 2016-12-07 | 上海泽生科技开发有限公司 | cMLCK基因导入 |
| CN115838437A (zh) * | 2022-11-04 | 2023-03-24 | 广州达安基因股份有限公司 | 人NT-proBNP融合蛋白及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7375185B2 (en) * | 2000-09-12 | 2008-05-20 | The United States Of America As Represented By The Department Of Health And Human Services | Cardiac myosin light chain kinase polypeptide, encoding nucleic acid, and methods of use |
| US9580515B2 (en) * | 2006-08-21 | 2017-02-28 | Zensun (Shanghai) Science & Technology, Co., Ltd. | Neukinase, a downstream protein of neuregulin |
| JP2009242388A (ja) * | 2008-03-14 | 2009-10-22 | National Cardiovascular Center | 心臓特異的キナーゼの心不全診断および治療への応用 |
| CN102416184A (zh) * | 2011-12-08 | 2012-04-18 | 哈尔滨医科大学 | microRNA-1的反义锁核苷酸序列在制备预防或治疗心肌梗死后心衰药物中的应用 |
| CN106177992A (zh) * | 2015-05-08 | 2016-12-07 | 上海泽生科技开发有限公司 | cMLCK基因导入 |
-
2015
- 2015-05-08 CN CN201510232415.6A patent/CN106177992A/zh active Pending
- 2015-05-08 CN CN202010310166.9A patent/CN111388682A/zh active Pending
-
2016
- 2016-06-14 AU AU2016260473A patent/AU2016260473A1/en not_active Abandoned
- 2016-06-14 WO PCT/CN2016/085699 patent/WO2016180377A1/zh not_active Ceased
- 2016-06-14 US US15/572,467 patent/US20180133291A1/en not_active Abandoned
- 2016-06-14 RU RU2017142779A patent/RU2017142779A/ru not_active Application Discontinuation
- 2016-06-14 JP JP2017558467A patent/JP2018515510A/ja active Pending
- 2016-06-14 CN CN201680025125.7A patent/CN107735109A/zh active Pending
- 2016-06-14 BR BR112017024065-3A patent/BR112017024065A2/pt not_active Application Discontinuation
- 2016-06-14 EP EP16792227.7A patent/EP3295959A4/en not_active Withdrawn
- 2016-06-14 KR KR1020177032419A patent/KR20190008511A/ko not_active Withdrawn
- 2016-06-14 CA CA2985396A patent/CA2985396A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20180133291A1 (en) | 2018-05-17 |
| RU2017142779A3 (https=) | 2019-12-03 |
| EP3295959A1 (en) | 2018-03-21 |
| KR20190008511A (ko) | 2019-01-24 |
| BR112017024065A2 (pt) | 2018-08-07 |
| EP3295959A4 (en) | 2019-01-02 |
| CN106177992A (zh) | 2016-12-07 |
| CN111388682A (zh) | 2020-07-10 |
| CA2985396A1 (en) | 2016-11-17 |
| CN107735109A (zh) | 2018-02-23 |
| WO2016180377A1 (zh) | 2016-11-17 |
| AU2016260473A1 (en) | 2017-12-21 |
| JP2018515510A (ja) | 2018-06-14 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20210125 |