RU2017116582A - Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины - Google Patents
Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины Download PDFInfo
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- RU2017116582A RU2017116582A RU2017116582A RU2017116582A RU2017116582A RU 2017116582 A RU2017116582 A RU 2017116582A RU 2017116582 A RU2017116582 A RU 2017116582A RU 2017116582 A RU2017116582 A RU 2017116582A RU 2017116582 A RU2017116582 A RU 2017116582A
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- RU
- Russia
- Prior art keywords
- umbilical cord
- cord blood
- genetically modified
- stimulating angiogenesis
- blood cells
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
- C12N15/861—Adenoviral vectors
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Urology & Nephrology (AREA)
- Plant Pathology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (2)
1. Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины, заключающийся в том, что в область ишемии вводят трансдуцированные комбинацией Ad VEGF+ Ad Ang мононуклеарные клетки крови пуповины.
2. Способ стимулирования ангиогенеза по п. 1, заключающийся в том, что трансдуцированные комбинацией Ad VEGF+ Ad Ang мононуклеарные клетки крови пуповины вводят в область ишемии в объеме 0,2 мл клеток, с трансдуцированными генами VEGF+ANG, с общим количеством вирусных частиц в объеме 2×1010.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2017116582A RU2663470C2 (ru) | 2017-05-11 | 2017-05-11 | Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2017116582A RU2663470C2 (ru) | 2017-05-11 | 2017-05-11 | Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017116582A true RU2017116582A (ru) | 2017-09-26 |
| RU2663470C2 RU2663470C2 (ru) | 2018-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017116582A RU2663470C2 (ru) | 2017-05-11 | 2017-05-11 | Способ стимулирования ангиогенеза с использованием генетически модифицированных клеток крови пуповины |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2663470C2 (ru) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006060779A2 (en) * | 2004-12-03 | 2006-06-08 | Case Western Reserve University | Novel methods, compositions and devices for inducing neovascularization |
| KR101919728B1 (ko) * | 2009-08-28 | 2018-11-16 | 세르노바 코포레이션 | 세포 이식 방법 및 장치 |
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2017
- 2017-05-11 RU RU2017116582A patent/RU2663470C2/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2663470C2 (ru) | 2018-08-06 |
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