RU2016145979A - PHARMACEUTICAL TABLETS "BIOBARDIN" OBTAINED BASED ON THE LIQUID PHASE OF THE POST-SPIRIT GRAIN BARD AND INTENDED FOR GASTROENTEROLOGY - Google Patents

PHARMACEUTICAL TABLETS "BIOBARDIN" OBTAINED BASED ON THE LIQUID PHASE OF THE POST-SPIRIT GRAIN BARD AND INTENDED FOR GASTROENTEROLOGY Download PDF

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Publication number
RU2016145979A
RU2016145979A RU2016145979A RU2016145979A RU2016145979A RU 2016145979 A RU2016145979 A RU 2016145979A RU 2016145979 A RU2016145979 A RU 2016145979A RU 2016145979 A RU2016145979 A RU 2016145979A RU 2016145979 A RU2016145979 A RU 2016145979A
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Russia
Prior art keywords
biobardin
liquid phase
granulate
intended
post
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RU2016145979A
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Russian (ru)
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RU2662064C2 (en
RU2016145979A3 (en
Inventor
Нелли Шаликовна Кайшева
Александр Шаликович Кайшев
Александр Михайлович Шевченко
Владимир Александрович Микелов
Original Assignee
федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации
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Priority to RU2016145979A priority Critical patent/RU2662064C2/en
Publication of RU2016145979A publication Critical patent/RU2016145979A/en
Publication of RU2016145979A3 publication Critical patent/RU2016145979A3/ru
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (1)

Твердая форма для перорального применения на основе зерновой послеспиртовой барды, включающая белки и аминокислоты, витамины, микроэлементы, обладающая биологической активностью, отличающаяся тем, что субстанцию «Биобардин», полученную из жидкой фазы барды и содержащую: 3,45% биогенных элементов (P, Mn, Mg, Zn, Fe, Cu, Со, Mo, Cr, V, Ni), 54,0% белков и аминокислот (в т.ч. 10,7% незаменимых: треонин, валин, метионин, изолейцин, лейцин, фенилаланин, гистидин лизин, аргинин), 8,8% восстанавливающих сахаров, 0,46% флавоноидов, 0,00055% витамина С, растворяют в воде для получения 50 мас. % раствора, 0,5 мл которого вводят в гранулят, приготовленный смешиванием в течение 5 мин 0,30 г лактозы (наполнителя) и 0,30 г полипласдона «Polyplasdone XL-10» (связывающего вещества); смесь растирают до образования однородной массы, подсушивают в псевдоожиженном слое при температуре 40°С в течение 30 мин (до остаточной влажности гранулята 3,3%), протирают через сито с диаметром отверстий 1,5 мм (№15), «опудривают» 0,001 г кальция стеарата (смазывающее вещество); полученный гранулят с сыпучестью 30,8 сек, углом естественного откоса 29°, насыпной плотностью 0,85 г/см3 прессуют для получения плоскоцилиндрических таблеток (с фаской и риской), характеризующихся коэффициентом прессуемости 0,14 г/мм, прочностью на раздавливание 73 Н, давлением выталкивания из матрицы 6,1 МПа, массой 1 таблетки 0,85 г, диаметром 13 мм, высотой 6 мм, сроком годности 5 лет, предназначенных для фармацевтического использования в качестве противоязвенного препарата, стимулятора желудочной секреции и моторики желудочно-кишечного тракта.A solid form for oral administration based on grain post-alcohol distillery stillage, including proteins and amino acids, vitamins, microelements, having biological activity, characterized in that the substance "Biobardin" obtained from the liquid phase of stillage and containing: 3.45% of nutrients (P, Mn, Mg, Zn, Fe, Cu, Co, Mo, Cr, V, Ni), 54.0% of proteins and amino acids (including 10.7% of the essential: threonine, valine, methionine, isoleucine, leucine, phenylalanine, histidine lysine, arginine), 8.8% reducing sugars, 0.46% flavonoids, 0.00055% vitamin C, dissolved in water to obtain I 50 wt. % solution, 0.5 ml of which is introduced into the granulate prepared by mixing for 5 minutes 0.30 g of lactose (filler) and 0.30 g of polyplasdone "Polyplasdone XL-10"(binder); the mixture is ground to a homogeneous mass, dried in a fluidized bed at a temperature of 40 ° C for 30 minutes (to a residual moisture content of granulate of 3.3%), rubbed through a sieve with a hole diameter of 1.5 mm (No. 15), “dusted” 0.001 g of calcium stearate (lubricant); the obtained granulate with a flowability of 30.8 seconds, a slope angle of 29 °, a bulk density of 0.85 g / cm 3 is pressed to obtain cylindrical tablets (chamfered and notched), characterized by a compressibility factor of 0.14 g / mm, crushing strength 73 N, ejection pressure from the matrix 6.1 MPa, weighing 1 tablet 0.85 g, diameter 13 mm, height 6 mm, shelf life 5 years, intended for pharmaceutical use as anti-ulcer drug, stimulator of gastric secretion and motility of the gastrointestinal tract .
RU2016145979A 2016-11-23 2016-11-23 Pharmaceutical tablets “biobardin”, obtained on the basis of the liquid phase of the post-alcohol cereal bard and intended for gastroenterology RU2662064C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016145979A RU2662064C2 (en) 2016-11-23 2016-11-23 Pharmaceutical tablets “biobardin”, obtained on the basis of the liquid phase of the post-alcohol cereal bard and intended for gastroenterology

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016145979A RU2662064C2 (en) 2016-11-23 2016-11-23 Pharmaceutical tablets “biobardin”, obtained on the basis of the liquid phase of the post-alcohol cereal bard and intended for gastroenterology

Publications (3)

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RU2016145979A true RU2016145979A (en) 2018-05-23
RU2016145979A3 RU2016145979A3 (en) 2018-05-23
RU2662064C2 RU2662064C2 (en) 2018-07-23

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RU2016145979A RU2662064C2 (en) 2016-11-23 2016-11-23 Pharmaceutical tablets “biobardin”, obtained on the basis of the liquid phase of the post-alcohol cereal bard and intended for gastroenterology

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2736186C1 (en) * 2019-07-29 2020-11-12 федеральное государственное бюджетное образовательное учреждение высшего образования "Волгоградский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for producing medicinal agents - nitrogen-containing betaines of hydrochlorides - based on post-distilled corn silage

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2404766C1 (en) * 2009-02-27 2010-11-27 ГОУ ВПО Пятигорская Государственная фармацевтическая академия Министерства здравоохранения и социального развития РФ Antioxidant medicinal agent based on distillers spent grains

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RU2662064C2 (en) 2018-07-23
RU2016145979A3 (en) 2018-05-23

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