RU2016132615A - A method for the treatment of radiation injuries of the pelvic organs - Google Patents

A method for the treatment of radiation injuries of the pelvic organs Download PDF

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Publication number
RU2016132615A
RU2016132615A RU2016132615A RU2016132615A RU2016132615A RU 2016132615 A RU2016132615 A RU 2016132615A RU 2016132615 A RU2016132615 A RU 2016132615A RU 2016132615 A RU2016132615 A RU 2016132615A RU 2016132615 A RU2016132615 A RU 2016132615A
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RU
Russia
Prior art keywords
treatment
assessed
degree
bladder
dosage
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RU2016132615A
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Russian (ru)
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RU2647423C2 (en
Inventor
Антон Андреевич Жариков
Олег Владимирович Терехов
Original Assignee
Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России)
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Application filed by Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России) filed Critical Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский радиологический центр" Министерства здравоохранения Российской Федерации (ФГБУ "НМИРЦ" Минздрава России)
Priority to RU2016132615A priority Critical patent/RU2647423C2/en
Publication of RU2016132615A publication Critical patent/RU2016132615A/en
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Publication of RU2647423C2 publication Critical patent/RU2647423C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Surgical Instruments (AREA)

Claims (1)

Способ лечения лучевых повреждений органов малого таза, включающий системное и местное воздействие лекарственным средством в область патологического очага, отличающийся тем, что вначале трансвагинально или трансректально вводят ультразвуковой датчик с адаптером, затем через канал адаптера в зону наибольшего интереса проводят инъекционную иглу и вводят однородную жидкую смесь рексода в дозировке от 6,4 млн. ЕД до 12,8 млн. ЕД совместно с дексометазоном в дозировке от 6,0 мг до 10,0 мг, при этом курс лечения проводят 5 инъекций через день с последующей оценкой эффективности лечения, причем с помощью ультразвукового обследования оценивают объем мочевого пузыря, строение пораженного органа и характер окружающих его тканей, а также определяют состояние почек, проводят оценку их размеров и состояние чашечно-лоханочной системы по степени ее расширения, по данным цистоскопии оценивают степень язвенного дефекта стенки мочевого пузыря, выраженности его гиперемии и отека; по результатам рентгеноконтрастных исследований оценивают степень восстановления уродинамики и характер пассажа кала.A method for treating radiation injuries of the pelvic organs, including systemic and local exposure to the drug in the area of the pathological focus, characterized in that the ultrasound probe with the adapter is first transvaginally or transrectally introduced, then an injection needle is passed through the adapter channel into the zone of greatest interest and a homogeneous liquid mixture is injected rexoda in a dosage of 6.4 million units to 12.8 million units in conjunction with dexomethasone in a dosage of 6.0 mg to 10.0 mg, while the course of treatment is 5 injections every other day after further evaluating the effectiveness of treatment, and using an ultrasound examination, the volume of the bladder, the structure of the affected organ and the nature of the surrounding tissues are assessed, as well as the state of the kidneys, their size and condition of the pyelocaliceal system are assessed by the degree of expansion, and the degree of cystoscopy is assessed ulcerative defect of the wall of the bladder, the severity of its hyperemia and edema; according to the results of X-ray contrast studies, the degree of restoration of urodynamics and the nature of the passage of feces are evaluated.
RU2016132615A 2016-08-09 2016-08-09 Method for treatment of pelvic organs radiation damage RU2647423C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016132615A RU2647423C2 (en) 2016-08-09 2016-08-09 Method for treatment of pelvic organs radiation damage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2016132615A RU2647423C2 (en) 2016-08-09 2016-08-09 Method for treatment of pelvic organs radiation damage

Publications (2)

Publication Number Publication Date
RU2016132615A true RU2016132615A (en) 2018-02-14
RU2647423C2 RU2647423C2 (en) 2018-03-15

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RU2016132615A RU2647423C2 (en) 2016-08-09 2016-08-09 Method for treatment of pelvic organs radiation damage

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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2242988C1 (en) * 2003-06-30 2004-12-27 Владивостокский государственный медицинский университет Method for treating and preventing radiation lesions of large intestinal inferior departments
US20100029590A1 (en) * 2007-02-14 2010-02-04 Prelief Inc. Methods for treating or preventing hemorrhagic cystitis using a glycerophosphate salt

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RU2647423C2 (en) 2018-03-15

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Effective date: 20180810