RU2016129877A - A method of obtaining a hydroxide of aluminum oil theo vaccine against campylobacteriosis - Google Patents

A method of obtaining a hydroxide of aluminum oil theo vaccine against campylobacteriosis Download PDF

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Publication number
RU2016129877A
RU2016129877A RU2016129877A RU2016129877A RU2016129877A RU 2016129877 A RU2016129877 A RU 2016129877A RU 2016129877 A RU2016129877 A RU 2016129877A RU 2016129877 A RU2016129877 A RU 2016129877A RU 2016129877 A RU2016129877 A RU 2016129877A
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RU
Russia
Prior art keywords
fetus
campylobacteriosis
campylobacter
oil
subspecies
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RU2016129877A
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Russian (ru)
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RU2644654C2 (en
Inventor
Александр Александрович Сухинин
Сергей Вадимович Герасимов
Светлана Анатольевна Макавчик
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Федеральное государственное бюджетное образовательное учреждение высшего образования Санкт-Петербургская государственная академия ветеринарной медицины
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Priority to RU2016129877A priority Critical patent/RU2644654C2/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Claims (2)

Способ получения гидроокись алюминиевой масляной тео-вакцины против кампилобактериоза, включающий отдельные стадии выделения и накопления возбудителя кампилобактериоза Campylobacter fetus subspecies fetus на питательной среде, смыва накопленных колоний возбудителя кампилобактериоза Campylobacter fetus subspecies fetus 0,9%-ным раствором NaCl, инактивацию накопленной биомассы возбудителя кампилобактериоза Campylobacter fetus subspecies fetus путем смешивания накопленной биомассы возбудителя кампилобактериоза Campylobacter fetu ssubspecies fetus с инактивирующим агентом с последующей выдержкой в бескислородных условиях при 37°C в течение 2 суток, соединения инактивированной биомассы с адъювантом гидроокись алюминия и внесения получившейся биомассы в масляный адъювант, состоящий из эмульгатора (биологически инертное кремнийорганическое соединение цетил-ПЭГ/ППГ - 10/1-диметикон) - 1,5% и масляной основы - вакцинное масло "М" по ТУ 381011224 - 98,5%, отличающийся тем, что в качестве инактивирующего агента используют теотропин в соотношении 0,3% теотропина к 100% биомассы возбудителя кампилобактериоза Campylobacter fetus subspecies fetus, в качестве адъюванта гидроокись алюминия и масляный адъювант, при следующем соотношении компонентов, мас. %:A method for producing hydroxide of aluminum oil theo vaccine against campylobacteriosis, which includes separate stages of isolation and accumulation of the causative agent of campylobacteriosis Campylobacter fetus subspecies fetus on a nutrient medium, washing off the accumulated colonies of the causative agent of campylobacteriosis Campylobacter fetus subspecies fetus 0.9% NaCl, inactivation of the bacteriosis of NaCl, inactivation Campylobacter fetus subspecies fetus by mixing the accumulated biomass of the causative agent of campylobacteriosis Campylobacter fetu ssubspecies fetus with an inactivating agent, followed by exposure to under oxygen conditions at 37 ° C for 2 days, compounding inactivated biomass with an adjuvant aluminum hydroxide and introducing the resulting biomass into an oil adjuvant consisting of an emulsifier (biologically inert silicone compound cetyl-PEG / PPG - 10/1-dimethicone) - 1.5 % and oil base - vaccine oil "M" according to TU 381011224 - 98.5%, characterized in that theotropin is used as an inactivating agent in the ratio of 0.3% theotropin to 100% of the biomass of Campylobacter fetus subspecies fetus, as an adjuvant hydrococks aluminum and oil adjuvant, in the following ratio of components, wt. %: суспензия клеток кампилобактера серогруппыCampylobacter Serogroup Cell Suspension fetus subspecies fetus в культуральной средеfetus subspecies fetus in culture medium с концентрацией 2×1010 КОЕ*/см3 with a concentration of 2 × 10 October * cfu / cm 3 (культура возбудителя кампилобактериоза(Campylobacteriosis pathogen culture Campylobacter fetus subspecies fetus)Campylobacter fetus subspecies fetus) 0,14%0.14% 0,9%-ный раствор NaCl0.9% NaCl solution 26,81%26.81% теотропинtheotropin 0,080.08 2%-ная суспензия AL(OH)3 2% suspension of AL (OH) 3 2,97%2.97% масляный адъювантoil adjuvant остальноеrest
RU2016129877A 2016-07-20 2016-07-20 Method for producing hydroxide of aluminum oil theo-vaccine against campylobacteriosis RU2644654C2 (en)

Priority Applications (1)

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RU2016129877A RU2644654C2 (en) 2016-07-20 2016-07-20 Method for producing hydroxide of aluminum oil theo-vaccine against campylobacteriosis

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Application Number Priority Date Filing Date Title
RU2016129877A RU2644654C2 (en) 2016-07-20 2016-07-20 Method for producing hydroxide of aluminum oil theo-vaccine against campylobacteriosis

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RU2016129877A true RU2016129877A (en) 2018-01-25
RU2644654C2 RU2644654C2 (en) 2018-02-13

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2021818C1 (en) * 1992-06-05 1994-10-30 Всероссийский государственный научно-исследовательский институт контроля, стандартизации и сертификации ветеринарных препаратов Associated vaccine against hay fever and campylobacteriosis of cattle
RU2086259C1 (en) * 1994-08-03 1997-08-10 Всероссийский научно-исследовательский и технологический институт биологической промышленности Mixed inactivated vaccine for control of chlamydiosis, campylobacteriosis, salmonellosis and leptospirosis in sheep and goats
UA67265A (en) * 2003-08-15 2004-06-15 Inst Exprm & Clinical Veterina Strain of bacteria campylobacter fetus subspecies fetus 5-ob serologic variant ii being used for the preparation of campilobacterial antigen and campilobacterial diagnostic serum

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Effective date: 20180721