RU2016124323A - A method for identifying patients with first-time attacks of acute porphyria - Google Patents

A method for identifying patients with first-time attacks of acute porphyria Download PDF

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Publication number
RU2016124323A
RU2016124323A RU2016124323A RU2016124323A RU2016124323A RU 2016124323 A RU2016124323 A RU 2016124323A RU 2016124323 A RU2016124323 A RU 2016124323A RU 2016124323 A RU2016124323 A RU 2016124323A RU 2016124323 A RU2016124323 A RU 2016124323A
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RU
Russia
Prior art keywords
porphyria
acute porphyria
acute
identifying patients
diagnosis
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RU2016124323A
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Russian (ru)
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RU2642723C2 (en
Inventor
Ярослав Сергеевич Пустовойт
Геннадий Мартинович Галстян
Эдуард Георгиевич Гемджян
Лана Анзоровна Горгидзе
Сергей Кириллович Кравченко
Ирина Владимировна Карпова
Вадим Леонидович Сурин
Валерий Григорьевич Савченко
Original Assignee
Федеральное государственное бюджетное учреждение "Гематологический научный центр" Министерства Здравоохранения Российской Федерации (ФГБУ "ГНЦ" МЗ РФ)
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Priority to RU2016124323A priority Critical patent/RU2642723C2/en
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Publication of RU2642723C2 publication Critical patent/RU2642723C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Food Science & Technology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)

Claims (1)

Способ выявления больных с острой порфирией, отличающийся тем, что определяют клинико-лабораторные критерии: пол, возраст; данные анамнеза: прием новых лекарственных препаратов, алкоголя, вновь выявленной патологии печени, появление симптомов заболевания в предменструальном периоде; наличие эмоциональной неустойчивости; определяют также наличие тахикардии, артериальной гипертензии, дискинезии желудочно-кишечного тракта: наличие запора или диареи, тошноты и рвоты, наличие болей в животе; выявляют наличие мочи темного цвета при дневном освещении, определяют наличие мышечной слабости в виде тетрапареза, парапареза, гемипареза; а также наличие нарушения контроля мочеиспускания и дефекации; выявляют нарушение чувствительности, определяют температуру тела, появление галлюцинаций и бреда, эпилептиформных припадков, а также определяют наличие одышки, пареза лицевого нерва, бульбарных нарушений, в качестве лабораторных показателей выявляют наличие лейкоцитоза более 12*109/л и СОЭ более 30 мм/ч, билирубинурии, эритроцитурии, превышение референсных значений показателей мочевой кислоты и мочевины и гипонатриемии; клинико-лабораторным критериям присваивают баллы в соответствии с таблицей 1, содержащейся в описании, полученные баллы суммируют, и если сумма баллов менее 5 - диагноз острой порфирии маловероятен, от 5 до 15 - порфирия возможна, если более 15, то диагноз острой порфирии высоковероятен.A method for identifying patients with acute porphyria, characterized in that they determine the clinical and laboratory criteria: gender, age; medical history: taking new drugs, alcohol, newly diagnosed liver pathology, the appearance of symptoms of the disease in the premenstrual period; the presence of emotional instability; also determine the presence of tachycardia, arterial hypertension, dyskinesia of the gastrointestinal tract: the presence of constipation or diarrhea, nausea and vomiting, the presence of abdominal pain; detect the presence of dark-colored urine in daylight, determine the presence of muscle weakness in the form of tetraparesis, paraparesis, hemiparesis; as well as the presence of impaired control of urination and bowel movements; detect a violation of sensitivity, determine body temperature, the appearance of hallucinations and delirium, epileptiform seizures, and also determine the presence of dyspnea, paresis of the facial nerve, bulbar disorders, as the laboratory indicators reveal the presence of leukocytosis more than 12 * 10 9 / l and ESR more than 30 mm / h , bilirubinuria, erythrocyturia, excess of the reference values of uric acid and urea and hyponatremia; Clinical and laboratory criteria are assigned points in accordance with Table 1 in the description, the obtained points are summarized, and if the total score is less than 5, the diagnosis of acute porphyria is unlikely, from 5 to 15 - porphyria is possible, if more than 15, then the diagnosis of acute porphyria is highly likely.
RU2016124323A 2016-06-20 2016-06-20 Method for identification of patients with first attacks of acute porphyria RU2642723C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2016124323A RU2642723C2 (en) 2016-06-20 2016-06-20 Method for identification of patients with first attacks of acute porphyria

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Application Number Priority Date Filing Date Title
RU2016124323A RU2642723C2 (en) 2016-06-20 2016-06-20 Method for identification of patients with first attacks of acute porphyria

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RU2016124323A true RU2016124323A (en) 2017-12-25
RU2642723C2 RU2642723C2 (en) 2018-01-25

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2234242C2 (en) * 2002-03-19 2004-08-20 Федеральное государственное унитарное предприятие Научно-исследовательский институт "Полюс" Method for determining biological tissue condition
RU2283036C1 (en) * 2005-03-18 2006-09-10 Государственное учреждение Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского (МОНИКИ) Method for predicting body intoxication with lead
RU2413209C1 (en) * 2010-03-12 2011-02-27 Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") Method for quantitative determination of hydrochloride of 5-aminolevulinic(5-amino-4-oxopentanoic) acid

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