RU2016115929A3 - - Google Patents

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Publication number
RU2016115929A3
RU2016115929A3 RU2016115929A RU2016115929A RU2016115929A3 RU 2016115929 A3 RU2016115929 A3 RU 2016115929A3 RU 2016115929 A RU2016115929 A RU 2016115929A RU 2016115929 A RU2016115929 A RU 2016115929A RU 2016115929 A3 RU2016115929 A3 RU 2016115929A3
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RU
Russia
Application number
RU2016115929A
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RU2650192C2 (ru
RU2016115929A (ru
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Publication of RU2016115929A3 publication Critical patent/RU2016115929A3/ru
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D333/00Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/72Benzo[c]thiophenes; Hydrogenated benzo[c]thiophenes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/14Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D301/00Preparation of oxiranes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/22Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
    • C07D303/18Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
    • C07D303/20Ethers with hydroxy compounds containing no oxirane rings
    • C07D303/24Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds
    • C07D303/26Ethers with hydroxy compounds containing no oxirane rings with polyhydroxy compounds having one or more free hydroxyl radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00Systems containing two condensed rings
    • C07C2602/02Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/14All rings being cycloaliphatic
    • C07C2602/24All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Catalysts (AREA)
RU2016115929A 2013-10-12 2014-10-11 Синтетическое промежуточное соединение максакальцитола, способ его получения и его применение RU2650192C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201310475989.7A CN103508999B (zh) 2013-10-12 2013-10-12 马沙骨化醇的合成中间体及其制备方法和用途
CN201310475989.7 2013-10-12
PCT/CN2014/088336 WO2015051762A1 (zh) 2013-10-12 2014-10-11 马沙骨化醇的合成中间体及其制备方法和用途

Publications (3)

Publication Number Publication Date
RU2016115929A RU2016115929A (ru) 2017-11-17
RU2016115929A3 true RU2016115929A3 (ru) 2018-03-22
RU2650192C2 RU2650192C2 (ru) 2018-04-11

Family

ID=49892479

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2016115929A RU2650192C2 (ru) 2013-10-12 2014-10-11 Синтетическое промежуточное соединение максакальцитола, способ его получения и его применение

Country Status (8)

Country Link
US (1) US20160237030A1 (ru)
EP (1) EP3056491B1 (ru)
JP (1) JP2016534151A (ru)
CN (1) CN103508999B (ru)
CA (1) CA2926961C (ru)
IL (1) IL245018A (ru)
RU (1) RU2650192C2 (ru)
WO (1) WO2015051762A1 (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508999B (zh) * 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途
CN107176918A (zh) * 2016-03-09 2017-09-19 湖南华腾制药有限公司 一种马沙骨化醇的纯化方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0078704B1 (en) * 1981-11-02 1987-04-29 Research Institute For Medicine And Chemistry Inc. Intermediates in the synthesis of vitamin d derivatives
JPS6024108A (ja) 1983-07-18 1985-02-06 株式会社クボタ 自動走行作業車
EP0227826B1 (en) 1985-08-02 1989-10-25 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel vitamin d analogues
JP3493037B2 (ja) 1991-12-18 2004-02-03 中外製薬株式会社 22−オキサコレカルシフェロール誘導体とその製造方法
GB9314400D0 (en) * 1993-07-12 1993-08-25 Leo Pharm Prod Ltd Produktionsaktieselskab) chemical compounds
KR20060038352A (ko) * 1996-09-03 2006-05-03 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 비타민 디 및 스테로이드 유도체들의 합성에 사용되는중간체들
IT1311923B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
US7074777B2 (en) 2000-04-19 2006-07-11 Chugai Seiyaku Kabushiki Kaisha Vitamin D derivatives
PL376148A1 (en) * 2002-10-23 2005-12-27 Leo Pharma A/S Vitamin d analogues, compositions comprising said analogues and their use
US20110157322A1 (en) * 2009-12-31 2011-06-30 Broadcom Corporation Controlling a pixel array to support an adaptable light manipulator
JP5563324B2 (ja) * 2010-02-03 2014-07-30 フォーモサ・ラボラトリーズ・インコーポレーテッド マキサカルシトール中間体およびその製造方法
WO2012122451A2 (en) * 2011-03-09 2012-09-13 Teva Pharmaceutical Industries Ltd. Polymorphs of maxacalcitol and process for the preparation of maxacalcitol
CN102796134B (zh) * 2012-08-31 2015-07-01 甘肃皓天化学科技有限公司 一种马沙骨化醇中间体的制备方法
CN103508999B (zh) * 2013-10-12 2015-05-13 浙江海正药业股份有限公司 马沙骨化醇的合成中间体及其制备方法和用途

Also Published As

Publication number Publication date
EP3056491B1 (en) 2018-08-08
IL245018A (en) 2017-10-31
IL245018A0 (en) 2016-05-31
CA2926961A1 (en) 2015-04-16
WO2015051762A1 (zh) 2015-04-16
JP2016534151A (ja) 2016-11-04
CN103508999A (zh) 2014-01-15
CA2926961C (en) 2018-12-18
CN103508999B (zh) 2015-05-13
RU2650192C2 (ru) 2018-04-11
EP3056491A4 (en) 2017-04-26
EP3056491A1 (en) 2016-08-17
RU2016115929A (ru) 2017-11-17
US20160237030A1 (en) 2016-08-18

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Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20191012