RU2015155795A - Медицинское устройство, содержащее коллаген VI - Google Patents
Медицинское устройство, содержащее коллаген VI Download PDFInfo
- Publication number
- RU2015155795A RU2015155795A RU2015155795A RU2015155795A RU2015155795A RU 2015155795 A RU2015155795 A RU 2015155795A RU 2015155795 A RU2015155795 A RU 2015155795A RU 2015155795 A RU2015155795 A RU 2015155795A RU 2015155795 A RU2015155795 A RU 2015155795A
- Authority
- RU
- Russia
- Prior art keywords
- medical device
- collagen
- microfibrils
- tissue contact
- linker molecules
- Prior art date
Links
- 102000008186 Collagen Human genes 0.000 title claims 11
- 108010035532 Collagen Proteins 0.000 title claims 11
- 229920001436 collagen Polymers 0.000 title claims 11
- 210000001724 microfibril Anatomy 0.000 claims 8
- 238000000034 method Methods 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 6
- 210000001519 tissue Anatomy 0.000 claims 5
- 239000002904 solvent Substances 0.000 claims 4
- 239000004053 dental implant Substances 0.000 claims 3
- 239000007943 implant Substances 0.000 claims 2
- 229920000729 poly(L-lysine) polymer Polymers 0.000 claims 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 claims 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 claims 1
- 229910045601 alloy Inorganic materials 0.000 claims 1
- 239000000956 alloy Substances 0.000 claims 1
- 239000000560 biocompatible material Substances 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 229910010293 ceramic material Inorganic materials 0.000 claims 1
- 239000011248 coating agent Substances 0.000 claims 1
- 238000000576 coating method Methods 0.000 claims 1
- 229910017052 cobalt Inorganic materials 0.000 claims 1
- 239000010941 cobalt Substances 0.000 claims 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 claims 1
- 229910052735 hafnium Inorganic materials 0.000 claims 1
- VBJZVLUMGGDVMO-UHFFFAOYSA-N hafnium atom Chemical compound [Hf] VBJZVLUMGGDVMO-UHFFFAOYSA-N 0.000 claims 1
- 229910052741 iridium Inorganic materials 0.000 claims 1
- GKOZUEZYRPOHIO-UHFFFAOYSA-N iridium atom Chemical compound [Ir] GKOZUEZYRPOHIO-UHFFFAOYSA-N 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000007769 metal material Substances 0.000 claims 1
- 229910052758 niobium Inorganic materials 0.000 claims 1
- 239000010955 niobium Substances 0.000 claims 1
- GUCVJGMIXFAOAE-UHFFFAOYSA-N niobium atom Chemical compound [Nb] GUCVJGMIXFAOAE-UHFFFAOYSA-N 0.000 claims 1
- 230000000399 orthopedic effect Effects 0.000 claims 1
- 239000004033 plastic Substances 0.000 claims 1
- 229910052715 tantalum Inorganic materials 0.000 claims 1
- GUVRBAGPIYLISA-UHFFFAOYSA-N tantalum atom Chemical compound [Ta] GUVRBAGPIYLISA-UHFFFAOYSA-N 0.000 claims 1
- 239000010936 titanium Substances 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 229910052720 vanadium Inorganic materials 0.000 claims 1
- LEONUFNNVUYDNQ-UHFFFAOYSA-N vanadium atom Chemical compound [V] LEONUFNNVUYDNQ-UHFFFAOYSA-N 0.000 claims 1
- 229910052726 zirconium Inorganic materials 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
- A61C8/00—Means to be fixed to the jaw-bone for consolidating natural teeth or for fixing dental prostheses thereon; Dental implants; Implanting tools
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L89/00—Compositions of proteins; Compositions of derivatives thereof
- C08L89/04—Products derived from waste materials, e.g. horn, hoof or hair
- C08L89/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin, e.g. gelatin
-
- C—CHEMISTRY; METALLURGY
- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09D—COATING COMPOSITIONS, e.g. PAINTS, VARNISHES OR LACQUERS; FILLING PASTES; CHEMICAL PAINT OR INK REMOVERS; INKS; CORRECTING FLUIDS; WOODSTAINS; PASTES OR SOLIDS FOR COLOURING OR PRINTING; USE OF MATERIALS THEREFOR
- C09D189/00—Coating compositions based on proteins; Coating compositions based on derivatives thereof
- C09D189/04—Products derived from waste materials, e.g. horn, hoof or hair
- C09D189/06—Products derived from waste materials, e.g. horn, hoof or hair derived from leather or skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/12—Materials or treatment for tissue regeneration for dental implants or prostheses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Engineering & Computer Science (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Polymers & Plastics (AREA)
- Dentistry (AREA)
- Materials For Medical Uses (AREA)
- Dental Prosthetics (AREA)
- Prostheses (AREA)
Claims (30)
1. Медицинское устройство, предназначенное для введения в живой организм, содержащее небиоразлагаемый субстрат, имеющий поверхность контакта с тканью, где указанная поверхность контакта с тканью по меньшей мере частично покрыта микрофибриллами коллагена VI.
2. Медицинское устройство по п. 1, где коллаген VI представлен в виде нативных микрофибрилл.
3. Медицинское устройство по п. 2, где нативные микрофибриллы содержат N- и С-концевые глобулярные домены с сохраненной структурой.
4. Медицинское устройство по п. 1, где указанный небиоразлагаемый субстрат содержит биологически совместимый материал, выбранный из металлических, керамических или пластмассовых материалов.
5. Медицинское устройство по п. 4, где указанный небиоразлагаемый субстрат содержит металлический материал, выбранный из группы, состоящей из титана, циркония, гафния, ванадия, ниобия, тантала, кобальта, и иридия, и их сплавов.
6. Медицинское устройство по п. 4, где указанный небиоразлагаемый субстрат содержит керамический материал.
7. Медицинское устройство по п. 1, представляющее собой несущий нагрузку имплантат.
8. Медицинское устройство по п. 1, представляющее собой стоматологический имплантат или его часть.
9. Медицинское устройство по п. 8, где указанные стоматологический имплантат или его часть выбраны из стоматологического фиксатора, стоматологического абатмента и однокомпонентного стоматологического имплантата.
10. Медицинское устройство по любому из пп. 1-6, представляющее собой слуховой аппарат с костной фиксацией.
11. Медицинское устройство по любому из пп. 1-6, представляющее собой стент.
12. Медицинское устройство по любому из пп. 1-6, представляющее собой шунт.
13. Медицинское устройство по любому из пп. 1-7, представляющее собой ортопедический имплантат.
14. Медицинское устройство по п. 1, где указанная поверхность покрыта слоем коллагена VI, имеющим толщину в диапазоне от 1 нм до 50 нм, например, от 5 нм до 50 нм.
15. Медицинское устройство по п. 1, где коллаген VI присоединен к указанной поверхности посредством линкерных молекул.
16. Способ покрытия поверхности медицинского устройства, включающий:
(1) обеспечение небиоразлагаемого субстрата, имеющего поверхность контакта с тканью
(2) возможно, присоединение линкерных молекул к указанной поверхности контакта с тканью;
и
(3) контактирование по меньшей мере части указанной поверхности контакта с тканью с раствором, содержащим микрофибриллы коллагена VI, для присоединения указанных микрофибрилл коллагена VI к указанной поверхности и/или к указанным линкерным молекулам.
17. Способ по п. 16, где стадию (2) осуществляют посредством
(2-а) нанесения раствора, содержащего линкерные молекулы и растворитель, на поверхность изделия, и
(2-b) удаления указанного растворителя.
18. Способ по п. 16 или 17, где указанные линкерные молекулы содержат поли-L-лизин (PLL).
19. Способ по п. 16, где стадию (3) осуществляют посредством
(3-а) нанесения раствора, содержащего микрофибриллы коллагена VI и растворитель, на указанную поверхность;
(3-b) инкубирования указанного субстрата с указанным раствором, нанесенным на указанную поверхность; и
(3-c) удаления указанного растворителя.
20. Способ по п. 19, где указанный раствор, содержащий микрофибриллы коллагена VI, имеет концентрацию фибрилл коллагена в диапазоне от 10 нМ до 10 мкМ.
21. Способ по п. 16, где указанный коллаген VI представлен в виде нативных микрофибрилл.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13173411.3 | 2013-06-24 | ||
| EP13173411 | 2013-06-24 | ||
| PCT/EP2014/062939 WO2014206856A1 (en) | 2013-06-24 | 2014-06-19 | Medical device comprising collagen-vi |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2015155795A true RU2015155795A (ru) | 2017-07-26 |
| RU2693408C2 RU2693408C2 (ru) | 2019-07-02 |
Family
ID=48745674
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015155795A RU2693408C2 (ru) | 2013-06-24 | 2014-06-19 | Медицинское устройство, содержащее коллаген VI |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20140377323A1 (ru) |
| EP (1) | EP3013378A1 (ru) |
| JP (1) | JP2016523635A (ru) |
| KR (1) | KR20160023720A (ru) |
| CN (1) | CN105358187B (ru) |
| AU (1) | AU2014301314B2 (ru) |
| BR (1) | BR112015032284A2 (ru) |
| CA (1) | CA2915572A1 (ru) |
| RU (1) | RU2693408C2 (ru) |
| WO (1) | WO2014206856A1 (ru) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3247386A4 (en) * | 2015-01-20 | 2018-10-03 | The Children's Medical Center Corporation | Anti-net compounds for treating and preventing fibrosis and for facilitating wound healing |
| IL258392A (en) * | 2018-03-27 | 2018-05-31 | Datum Dental Ltd | A block of defined shape containing collagen |
| GB201909298D0 (en) * | 2019-06-28 | 2019-08-14 | Colzyx Ab | Novel compositions and uses thereof |
| CN111282022A (zh) * | 2020-02-14 | 2020-06-16 | 昆明医科大学 | 一种辅助构建胶原蛋白超薄膜组织工程骨的方法 |
| GB202016456D0 (en) * | 2020-10-16 | 2020-12-02 | Colzyx Ab | Novel bioactive peptide combinations and uses thereof |
| WO2023141237A1 (en) * | 2022-01-20 | 2023-07-27 | Cell and Molecular Tissue Engineering, LLC | Methods and products to detect, minimize and treat trap-related tissue reactions and tissue injury associated with medical devices |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL76079A (en) * | 1985-08-13 | 1991-03-10 | Univ Ramot | Collagen implants |
| US7883693B2 (en) * | 1995-12-18 | 2011-02-08 | Angiodevice International Gmbh | Compositions and systems for forming crosslinked biomaterials and methods of preparation of use |
| US6177609B1 (en) * | 1997-03-10 | 2001-01-23 | Meadox Medicals, Inc. | Self-aggregating protein compositions and use as sealants |
| RU2295980C1 (ru) * | 2005-09-08 | 2007-03-27 | Григорий Федорович Назаренко | Имплантат для восстановления костной и/или хрящевой ткани и способ его получения |
| EP2399618A1 (en) * | 2010-06-22 | 2011-12-28 | Planton GmbH | Antimicrobial medical devices |
| EP2717933B1 (en) * | 2011-06-13 | 2019-05-01 | Dentsply IH AB | Collagen coated article |
-
2014
- 2014-06-19 JP JP2016520490A patent/JP2016523635A/ja active Pending
- 2014-06-19 BR BR112015032284A patent/BR112015032284A2/pt not_active Application Discontinuation
- 2014-06-19 EP EP14731282.1A patent/EP3013378A1/en not_active Withdrawn
- 2014-06-19 KR KR1020157036656A patent/KR20160023720A/ko not_active Application Discontinuation
- 2014-06-19 CN CN201480036076.8A patent/CN105358187B/zh active Active
- 2014-06-19 CA CA2915572A patent/CA2915572A1/en not_active Abandoned
- 2014-06-19 RU RU2015155795A patent/RU2693408C2/ru active
- 2014-06-19 AU AU2014301314A patent/AU2014301314B2/en active Active
- 2014-06-19 WO PCT/EP2014/062939 patent/WO2014206856A1/en active Application Filing
- 2014-06-24 US US14/313,347 patent/US20140377323A1/en not_active Abandoned
-
2018
- 2018-12-06 US US16/211,914 patent/US20190105374A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| RU2693408C2 (ru) | 2019-07-02 |
| CA2915572A1 (en) | 2014-12-31 |
| WO2014206856A1 (en) | 2014-12-31 |
| US20140377323A1 (en) | 2014-12-25 |
| US20190105374A1 (en) | 2019-04-11 |
| KR20160023720A (ko) | 2016-03-03 |
| BR112015032284A2 (pt) | 2017-07-25 |
| JP2016523635A (ja) | 2016-08-12 |
| CN105358187B (zh) | 2018-06-22 |
| AU2014301314A1 (en) | 2015-12-24 |
| CN105358187A (zh) | 2016-02-24 |
| AU2014301314B2 (en) | 2017-06-15 |
| EP3013378A1 (en) | 2016-05-04 |
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