RU2015154806A - TSPO translocator protein ligands with antidepressant and nootropic activity - Google Patents

TSPO translocator protein ligands with antidepressant and nootropic activity Download PDF

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Publication number
RU2015154806A
RU2015154806A RU2015154806A RU2015154806A RU2015154806A RU 2015154806 A RU2015154806 A RU 2015154806A RU 2015154806 A RU2015154806 A RU 2015154806A RU 2015154806 A RU2015154806 A RU 2015154806A RU 2015154806 A RU2015154806 A RU 2015154806A
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RU
Russia
Prior art keywords
antidepressant
protein ligands
translocator protein
nootropic activity
tspo
Prior art date
Application number
RU2015154806A
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Russian (ru)
Other versions
RU2015154806A3 (en
RU2699568C2 (en
Inventor
Сергей Борисович Середенин
Милада Альнордовна Яркова
Полина Юрьевна Поварнина
Григорий Владимирович Мокров
Татьяна Александровна Гудашева
Original Assignee
Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова"
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Application filed by Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" filed Critical Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова"
Priority to RU2015154806A priority Critical patent/RU2699568C2/en
Publication of RU2015154806A publication Critical patent/RU2015154806A/en
Publication of RU2015154806A3 publication Critical patent/RU2015154806A3/ru
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Publication of RU2699568C2 publication Critical patent/RU2699568C2/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

1. Применение лиганда транслокаторного белка - N-бензил-N-метил-1-фенилпирроло[1,2-a]пиразин-3-карбоксамида - в качестве антидепрессантного и ноотропного средства.1. The use of a translocation protein ligand - N-benzyl-N-methyl-1-phenylpyrrolo [1,2- a ] pyrazine-3-carboxamide - as an antidepressant and nootropic agent. 2. Применение лиганда транслокаторного белка - N-бутил-N-метил-1-фенилпирроло[1,2-а]пиразин-3-карбоксамида - в качестве антидепрессантного средства.2. The use of a translocation protein ligand, N-butyl-N-methyl-1-phenylpyrrolo [1,2- a ] pyrazine-3-carboxamide, as an antidepressant agent.
RU2015154806A 2015-12-21 2015-12-21 Ligands of translocator protein tspo, having antidepressant and nootropic activity RU2699568C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2015154806A RU2699568C2 (en) 2015-12-21 2015-12-21 Ligands of translocator protein tspo, having antidepressant and nootropic activity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2015154806A RU2699568C2 (en) 2015-12-21 2015-12-21 Ligands of translocator protein tspo, having antidepressant and nootropic activity

Publications (3)

Publication Number Publication Date
RU2015154806A true RU2015154806A (en) 2017-06-26
RU2015154806A3 RU2015154806A3 (en) 2019-07-17
RU2699568C2 RU2699568C2 (en) 2019-09-06

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RU2015154806A RU2699568C2 (en) 2015-12-21 2015-12-21 Ligands of translocator protein tspo, having antidepressant and nootropic activity

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2757476C2 (en) * 2020-04-14 2021-10-18 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Leucyltryptophan tspo ligands with anxiolytic activity
CN114432455A (en) * 2022-03-25 2022-05-06 江苏省人民医院（南京医科大学第一附属医院） Preparation and application of medicine for treating chronic pain-depression co-disease

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU735401B2 (en) * 1996-08-28 2001-07-05 Pfizer Inc. Substituted 6,5-hetero-bicyclic derivatives
RU2194707C2 (en) * 2000-04-04 2002-12-20 Научно-исследовательский институт фармакологии РАМН Pyrrolo[1,2-a]pyrazines or their fumarates showing antiarrhythmic and anti-ischemic activity
FR2919288B1 (en) * 2007-07-27 2009-09-04 Sanofi Aventis Sa 1,2,3,4-TETRAHYDROPYRROLO [1,2-A] PYRAZINE-6-CARBOXAMIDE DERIVATIVES, THEIR PREPARATION AND THERAPEUTIC USE THEREOF
EP2168963A1 (en) * 2008-09-25 2010-03-31 Linnea S.A. Process for the preparation of vinpocetine and apovincamine
EP2718464A1 (en) * 2011-06-06 2014-04-16 Imperial Innovations Limited Methods to predict binding affinity of tspo imaging agents to tspo

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2757476C2 (en) * 2020-04-14 2021-10-18 Федеральное государственное бюджетное научное учреждение "Научно-исследовательский институт фармакологии имени В.В. Закусова" Leucyltryptophan tspo ligands with anxiolytic activity
CN114432455A (en) * 2022-03-25 2022-05-06 江苏省人民医院（南京医科大学第一附属医院） Preparation and application of medicine for treating chronic pain-depression co-disease

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Publication number Publication date
RU2015154806A3 (en) 2019-07-17
RU2699568C2 (en) 2019-09-06

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