RU2015140498A - Фармацевтические композиции для ректального введения - Google Patents
Фармацевтические композиции для ректального введения Download PDFInfo
- Publication number
- RU2015140498A RU2015140498A RU2015140498A RU2015140498A RU2015140498A RU 2015140498 A RU2015140498 A RU 2015140498A RU 2015140498 A RU2015140498 A RU 2015140498A RU 2015140498 A RU2015140498 A RU 2015140498A RU 2015140498 A RU2015140498 A RU 2015140498A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- composition according
- paragraphs
- total weight
- foam
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title claims 28
- 239000000203 mixture Substances 0.000 claims 12
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000006260 foam Substances 0.000 claims 5
- 239000003380 propellant Substances 0.000 claims 5
- 239000003995 emulsifying agent Substances 0.000 claims 4
- 150000005828 hydrofluoroalkanes Chemical class 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 241000193163 Clostridioides difficile Species 0.000 claims 3
- 239000006265 aqueous foam Substances 0.000 claims 3
- 239000004094 surface-active agent Substances 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000000443 aerosol Substances 0.000 claims 2
- 239000008365 aqueous carrier Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 210000001072 colon Anatomy 0.000 claims 2
- 210000003405 ileum Anatomy 0.000 claims 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 claims 2
- 238000012423 maintenance Methods 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 210000000664 rectum Anatomy 0.000 claims 2
- 206010012735 Diarrhoea Diseases 0.000 claims 1
- LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 239000004743 Polypropylene Substances 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000002280 amphoteric surfactant Substances 0.000 claims 1
- 229940035676 analgesics Drugs 0.000 claims 1
- 229940035674 anesthetics Drugs 0.000 claims 1
- 239000003945 anionic surfactant Substances 0.000 claims 1
- 239000000730 antalgic agent Substances 0.000 claims 1
- 239000003242 anti bacterial agent Substances 0.000 claims 1
- 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000003429 antifungal agent Substances 0.000 claims 1
- 239000002246 antineoplastic agent Substances 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000003443 antiviral agent Substances 0.000 claims 1
- 239000003093 cationic surfactant Substances 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims 1
- 239000003974 emollient agent Substances 0.000 claims 1
- 239000003623 enhancer Substances 0.000 claims 1
- 150000002148 esters Chemical class 0.000 claims 1
- LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 claims 1
- 229940093471 ethyl oleate Drugs 0.000 claims 1
- 150000002191 fatty alcohols Chemical class 0.000 claims 1
- 238000005187 foaming Methods 0.000 claims 1
- 239000004088 foaming agent Substances 0.000 claims 1
- 239000003193 general anesthetic agent Substances 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 150000002314 glycerols Chemical class 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 239000003906 humectant Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 239000001282 iso-butane Substances 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 230000003232 mucoadhesive effect Effects 0.000 claims 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 claims 1
- 239000002736 nonionic surfactant Substances 0.000 claims 1
- 235000008390 olive oil Nutrition 0.000 claims 1
- 239000004006 olive oil Substances 0.000 claims 1
- 150000002895 organic esters Chemical class 0.000 claims 1
- 239000003002 pH adjusting agent Substances 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920005862 polyol Polymers 0.000 claims 1
- 150000003077 polyols Chemical class 0.000 claims 1
- 229920001451 polypropylene glycol Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 229940002612 prodrug Drugs 0.000 claims 1
- 239000000651 prodrug Substances 0.000 claims 1
- 239000001294 propane Substances 0.000 claims 1
- 229940096976 rectal foam Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 150000003431 steroids Chemical class 0.000 claims 1
- 239000000375 suspending agent Substances 0.000 claims 1
- 239000000725 suspension Substances 0.000 claims 1
- 239000002562 thickening agent Substances 0.000 claims 1
- 235000015112 vegetable and seed oil Nutrition 0.000 claims 1
- 239000008158 vegetable oil Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0031—Rectum, anus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/122—Foams; Dry foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN711/MUM/2013 | 2013-03-08 | ||
| IN711MU2013 IN2013MU00711A (OSRAM) | 2013-03-08 | 2014-03-07 | |
| PCT/GB2014/050678 WO2014135891A1 (en) | 2013-03-08 | 2014-03-07 | Pharmaceutical compositions for rectal administration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2015140498A true RU2015140498A (ru) | 2017-04-13 |
Family
ID=50382472
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2015140498A RU2015140498A (ru) | 2013-03-08 | 2014-03-07 | Фармацевтические композиции для ректального введения |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20160002278A1 (OSRAM) |
| EP (1) | EP2964196A1 (OSRAM) |
| JP (1) | JP2016511268A (OSRAM) |
| CN (1) | CN105142612A (OSRAM) |
| AU (1) | AU2014224397A1 (OSRAM) |
| BR (1) | BR112015021501A2 (OSRAM) |
| CA (1) | CA2902852A1 (OSRAM) |
| IN (1) | IN2013MU00711A (OSRAM) |
| MX (1) | MX2015011894A (OSRAM) |
| RU (1) | RU2015140498A (OSRAM) |
| WO (1) | WO2014135891A1 (OSRAM) |
| ZA (1) | ZA201401683B (OSRAM) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104546672B (zh) * | 2014-12-19 | 2017-12-22 | 华北制药集团新药研究开发有限责任公司 | 一种非达霉素肠溶制剂 |
| GB201509326D0 (en) | 2015-05-29 | 2015-07-15 | Antibio Tx Aps | Novel use |
| RU2646495C2 (ru) * | 2015-12-28 | 2018-03-05 | Общество с ограниченной ответственностью "Научно-техническая производственная фирма "Анта-Медикал" | Фармацевтические композиции в форме ректальных суппозиториев, содержащие нефопама гидрохлорид (варианты), их применение для лечения острого и хронического болевого синдрома и способы получения |
| US20190298735A1 (en) * | 2016-07-08 | 2019-10-03 | Vanderbilt University | Treatment and prevention of clostridium difficile colitis using misoprostol |
| RU2661618C1 (ru) * | 2017-11-23 | 2018-07-17 | Общество с ограниченной ответственностью "Научно-техническая производственная фирма "Анта-Медикал" | Суппозитории нефопама для лечения острого и хронического болевого синдрома на липофильной основе и способ их получения |
| RU2661617C1 (ru) * | 2017-11-23 | 2018-07-17 | Общество с ограниченной ответственностью "Научно-техническая производственная фирма "Анта-Медикал" | Суппозитории нефопама для лечения острого и хронического болевого синдрома на гидрофильной эмульсионной основе и способ их получения |
| EP3796951A4 (en) * | 2018-05-19 | 2021-07-07 | Gary Binyamin | FOAM FORMULATIONS AND BODY ADMINISTRATION PROCEDURES |
| CN109394694A (zh) * | 2018-09-30 | 2019-03-01 | 北京兴源联合医药科技有限公司 | 一种无水泡沫剂 |
| CN112791048B (zh) * | 2020-12-31 | 2023-01-17 | 海南海神同洲制药有限公司 | 一种硝酸舍他康唑栓及其制备方法 |
| CA3216267A1 (en) * | 2021-04-22 | 2022-10-27 | Glenn W. Laub | Foam compositions for treating clostridioides difficile infections |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1458512A (en) | 1973-11-22 | 1976-12-15 | Lepetit Spa | Antibiotic substance |
| US5767096A (en) * | 1996-07-12 | 1998-06-16 | Abbott Laboratories | Bromotiacumicin compounds |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| IL152486A0 (en) * | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| US9211259B2 (en) * | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US20080206161A1 (en) * | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| US20070292461A1 (en) * | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US20070292355A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
| US8486374B2 (en) * | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| CA2536482C (en) * | 2003-08-25 | 2012-07-24 | Foamix Ltd. | Penetrating pharmaceutical foam |
| US7906489B2 (en) | 2004-05-14 | 2011-03-15 | Optimer Pharmaceuticals, Inc. | 18-membered macrocycles and analogs thereof |
| US7378508B2 (en) | 2007-01-22 | 2008-05-27 | Optimer Pharmaceuticals, Inc. | Polymorphic crystalline forms of tiacumicin B |
| US20080292560A1 (en) * | 2007-01-12 | 2008-11-27 | Dov Tamarkin | Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| PE20130310A1 (es) * | 2010-05-18 | 2013-04-06 | Optimer Pharmaceuticals Inc | Tratamiento de infecciones de clostridium difficile en pacientes bajo terapia con antibioticos |
| US20130022575A1 (en) | 2011-07-19 | 2013-01-24 | Microbial Rx | Systems and methods of replacing intestinal flora |
-
2014
- 2014-03-07 ZA ZA2014/01683A patent/ZA201401683B/en unknown
- 2014-03-07 CA CA2902852A patent/CA2902852A1/en not_active Abandoned
- 2014-03-07 EP EP14712706.2A patent/EP2964196A1/en not_active Withdrawn
- 2014-03-07 JP JP2015560777A patent/JP2016511268A/ja active Pending
- 2014-03-07 BR BR112015021501A patent/BR112015021501A2/pt not_active IP Right Cessation
- 2014-03-07 CN CN201480012934.5A patent/CN105142612A/zh active Pending
- 2014-03-07 AU AU2014224397A patent/AU2014224397A1/en not_active Abandoned
- 2014-03-07 WO PCT/GB2014/050678 patent/WO2014135891A1/en not_active Ceased
- 2014-03-07 RU RU2015140498A patent/RU2015140498A/ru not_active Application Discontinuation
- 2014-03-07 MX MX2015011894A patent/MX2015011894A/es unknown
- 2014-03-07 IN IN711MU2013 patent/IN2013MU00711A/en unknown
- 2014-03-07 US US14/770,315 patent/US20160002278A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| MX2015011894A (es) | 2015-12-15 |
| IN2013MU00711A (OSRAM) | 2015-06-26 |
| AU2014224397A1 (en) | 2015-09-10 |
| US20160002278A1 (en) | 2016-01-07 |
| CA2902852A1 (en) | 2014-09-12 |
| JP2016511268A (ja) | 2016-04-14 |
| ZA201401683B (en) | 2017-06-28 |
| WO2014135891A1 (en) | 2014-09-12 |
| EP2964196A1 (en) | 2016-01-13 |
| BR112015021501A2 (pt) | 2017-07-18 |
| CN105142612A (zh) | 2015-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20170309 |