RU2014153254A - METHOD FOR Predicting Predisposition to the Development of Posttraumatic Osteoarthrosis of the Knee Joint - Google Patents

METHOD FOR Predicting Predisposition to the Development of Posttraumatic Osteoarthrosis of the Knee Joint Download PDF

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RU2014153254A
RU2014153254A RU2014153254A RU2014153254A RU2014153254A RU 2014153254 A RU2014153254 A RU 2014153254A RU 2014153254 A RU2014153254 A RU 2014153254A RU 2014153254 A RU2014153254 A RU 2014153254A RU 2014153254 A RU2014153254 A RU 2014153254A
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knee joint
development
genotyping
predisposition
osteoarthrosis
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RU2014153254A
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RU2600860C2 (en
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Валерий Валентинович Внуков
Светлана Борисовна Панина
Игорь Владимирович Кролевец
Наталья Петровна Милютина
Анжелика Аршаковна Ананян
Михаил Алексеевич Забродин
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федеральное государственное автономное образовательное учреждение высшего образования "Южный федеральный университет"
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Abstract

1. Способ диагностики предрасположенности к посттравматическому остеоартрозу коленного сустава, включающий генотипирование полиморфизма гена, отличающийся тем, что у исследуемых пациентов проводят генотипирование полиморфизма rs2276109 (A-82G) гена ММР-12, при этом при выявлении генотипа GG диагностируют генетическую предрасположенность к развитию посттравматического остеоартроза коленного сустава.2. Способ по п. 1, в котором генотипирование проводят с помощью полимеразной цепной реакции (ПЦР).1. A method for diagnosing a predisposition to post-traumatic osteoarthritis of the knee joint, including genotyping of a polymorphism of a gene, characterized in that the studied patients carry out genotyping of the rs2276109 (A-82G) polymorphism of the MMP-12 gene, while in identifying the GG genotype, a genetic predisposition to the development of post-traumatic osteoarthritis is diagnosed knee joint. 2. The method of claim 1, wherein the genotyping is carried out using a polymerase chain reaction (PCR).

Claims (2)

1. Способ диагностики предрасположенности к посттравматическому остеоартрозу коленного сустава, включающий генотипирование полиморфизма гена, отличающийся тем, что у исследуемых пациентов проводят генотипирование полиморфизма rs2276109 (A-82G) гена ММР-12, при этом при выявлении генотипа GG диагностируют генетическую предрасположенность к развитию посттравматического остеоартроза коленного сустава.1. A method for diagnosing a predisposition to post-traumatic osteoarthritis of the knee joint, including genotyping of a polymorphism of a gene, characterized in that the studied patients carry out genotyping of the rs2276109 (A-82G) polymorphism of the MMP-12 gene, while in identifying the GG genotype, a genetic predisposition to the development of post-traumatic osteoarthritis is diagnosed knee joint. 2. Способ по п. 1, в котором генотипирование проводят с помощью полимеразной цепной реакции (ПЦР). 2. The method according to p. 1, in which genotyping is carried out using polymerase chain reaction (PCR).
RU2014153254/15A 2014-12-25 2014-12-25 Method for prediction of predisposition to course of posttraumatic osteoarthrosis of knee joint RU2600860C2 (en)

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RU2014153254/15A RU2600860C2 (en) 2014-12-25 2014-12-25 Method for prediction of predisposition to course of posttraumatic osteoarthrosis of knee joint

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RU2014153254/15A RU2600860C2 (en) 2014-12-25 2014-12-25 Method for prediction of predisposition to course of posttraumatic osteoarthrosis of knee joint

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RU2600860C2 RU2600860C2 (en) 2016-10-27

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Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2646456C1 (en) * 2017-01-19 2018-03-05 Федеральное государственное бюджетное образовательное учреждение высшего образования Читинская государственная медицинская академия Министерства здравоохранения российской федерации Method for prediction of self-existing coxarthrosis development

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005031003A1 (en) * 2003-09-22 2005-04-07 The Regents Of The University Of California Mutations in wnt-frizzled signaling pathways associated with osteoarthritis
WO2009017052A1 (en) * 2007-07-27 2009-02-05 Riken Osteoarthritis-sensitive gene
RU2436500C1 (en) * 2010-06-21 2011-12-20 Федеральное государственное учреждение "Нижегородский научно-исследовательский институт травматологии и ортопедии Федерального агентства по высокотехнологичной медицинской помощи" Method of early diagnostics of posttraumatic osteoarthrosis

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