RU2014152938A - SORBENT FOR SEPARATION OF OPTICAL ISOMERS OF SUBSTANCES AND THEIR ANALYSIS IN BIOLOGICAL LIQUIDS BY HPLC AND METHOD OF ITS PRODUCTION - Google Patents
SORBENT FOR SEPARATION OF OPTICAL ISOMERS OF SUBSTANCES AND THEIR ANALYSIS IN BIOLOGICAL LIQUIDS BY HPLC AND METHOD OF ITS PRODUCTION Download PDFInfo
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- RU2014152938A RU2014152938A RU2014152938A RU2014152938A RU2014152938A RU 2014152938 A RU2014152938 A RU 2014152938A RU 2014152938 A RU2014152938 A RU 2014152938A RU 2014152938 A RU2014152938 A RU 2014152938A RU 2014152938 A RU2014152938 A RU 2014152938A
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- RU
- Russia
- Prior art keywords
- silica gel
- sorbent
- optical isomers
- eremomycin
- hplc
- Prior art date
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- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
1. Сорбент для разделения оптических изомеров веществ и для их анализа в биологических жидкостях методом ВЭЖХ, содержащий силикагель, модифицированный гликопептидным антибиотиком эремомицином, отличающийся тем, что он дополнительно модифицирован бычьим сывороточным альбумином.2. Способ получения сорбента для хроматографии оптических изомеров, включающий модифицирование поверхности силикагеля эпоксигруппами, иммобилизацию эремомицина на поверхности силикагеля с привитыми эпоксигруппами, промывку, сушку, отличающийся тем, что силикагель, модифицированный эремомицином, после сушки подвергают взаимодействию с бычьим сывороточным альбумином, глутаровым альдегидом и тетрагидроборатом натрия.1. Sorbent for the separation of optical isomers of substances and for their analysis in biological fluids by HPLC, containing silica gel modified with the glycopeptide antibiotic eremomycin, characterized in that it is further modified with bovine serum albumin. 2. A method of producing a sorbent for chromatography of optical isomers, including modifying the surface of silica gel with epoxy groups, immobilizing eremomycin on the surface of silica gel with grafted epoxy groups, washing, drying, characterized in that the silica gel modified with eremomycin is subjected to interaction with bovine serum albumin amide tetrahydride, .
Claims (2)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014152938/05A RU2592893C2 (en) | 2014-12-26 | 2014-12-26 | Sorbent for separation of optical isomers of substances and analysis thereof in biological fluids by hplc and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2014152938/05A RU2592893C2 (en) | 2014-12-26 | 2014-12-26 | Sorbent for separation of optical isomers of substances and analysis thereof in biological fluids by hplc and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2014152938A true RU2014152938A (en) | 2016-07-20 |
| RU2592893C2 RU2592893C2 (en) | 2016-07-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014152938/05A RU2592893C2 (en) | 2014-12-26 | 2014-12-26 | Sorbent for separation of optical isomers of substances and analysis thereof in biological fluids by hplc and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2592893C2 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2642796C1 (en) * | 2017-03-07 | 2018-01-26 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Башкирский государственный университет" | Method for obtaining enantioselective sorbent |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7008533B2 (en) * | 1994-02-22 | 2006-03-07 | Curators Of The University Of Missouri | Macrocyclic antibiotics as separation agents |
| RU2255802C1 (en) * | 2004-06-17 | 2005-07-10 | Закрытое акционерное общество "БиоХимМак СТ" | Sorbent for resolution of optical isomers and a method for preparation thereof |
| RU2348455C2 (en) * | 2006-10-10 | 2009-03-10 | Закрытое акционерное общество "БиоХимМак СТ" | Sorbent for optic isomer chromatography and method of its obtainment |
| AT509192B1 (en) * | 2010-06-24 | 2011-07-15 | Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems | SORPTION FOR ENDOTOXINES |
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2014
- 2014-12-26 RU RU2014152938/05A patent/RU2592893C2/en active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2592893C2 (en) | 2016-07-27 |
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