RU2014111445A - ANTIMICROBIAL COMPOSITIONS AND METHODS OF APPLICATION - Google Patents

ANTIMICROBIAL COMPOSITIONS AND METHODS OF APPLICATION Download PDF

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RU2014111445A
RU2014111445A RU2014111445/15A RU2014111445A RU2014111445A RU 2014111445 A RU2014111445 A RU 2014111445A RU 2014111445/15 A RU2014111445/15 A RU 2014111445/15A RU 2014111445 A RU2014111445 A RU 2014111445A RU 2014111445 A RU2014111445 A RU 2014111445A
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weight
concentration
composition
alcohol
antimicrobial composition
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RU2014111445/15A
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RU2648456C2 (en
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Януш СТЕЧКО
Стефен Р. ЭШ
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Зурекс Фарма, Инк.
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
    • A01N43/84—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms six-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02—Acyclic compounds
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/02—Saturated carboxylic acids or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/065—Diphenyl-substituted acyclic alcohols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/16—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using chemical substances
    • A61L2/18—Liquid substances or solutions comprising solids or dissolved gases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Abstract

1. Способ дезинфекции поверхности кожи, включающий нанесение антимикробной композиции на поверхность кожи пациента, которая нуждается в дезинфекции, где антимикробная композиция содержит (а) спирт, (b) органическую кислоту, (с) парабен и (d) окислительно-восстановительное соединение.2. Способ по п. 1, где антимикробная композиция содержит приблизительно от 1,5% до приблизительно 15% по массе лимонной кислоты, от 0,01% до приблизительно 1% по массе парабена и приблизительно от 0,01% до приблизительно 0,2% по массе окислительно-восстановительного соединения.3. Способ по п. 1, где спирт представляет собой этанол, изопропиловый спирт, н-пропанол, или их смесь.4. Способ по п. 1, где композиция содержит метилпарабен в концентрации приблизительно от 0,1% до приблизительно 0,4% по массе и пропилпарабен в концентрации приблизительно от 0,01% до приблизительно 0,2% по массе.5. Способ по п. 1, где композиция содержит приблизительно от 0,03% до приблизительно 0,12% по массе метиленового синего.6. Способ по п. 1, где композиция содержит приблизительно от 4% до приблизительно 8% по массе лимонной кислоты.7. Способ по п. 1, где композиция содержит приблизительно от 0,2% до приблизительно 0,9% по массе цитратной соли.8. Способ по п. 1, где композиция содержит (а) этанол, изопропиловый спирт, н-пропанол, или их смесь, (b) лимонную кислоту в концентрации приблизительно от 4% до приблизительно 8% по массе, (с) метиленовый синий в концентрации приблизительно от0,03% до приблизительно 0,09 % по массе, (d) метилпарабена в концентрации приблизительно от 0,1 до приблизительно 0,4% по массе, (е) пропилпарабен в концентрации приблизительно от 0,01% до 0,2% по массе, и (f) цитрат натрия в концентрации приб�1. A method of disinfecting a skin surface, comprising applying an antimicrobial composition to a patient’s skin surface that needs to be disinfected, wherein the antimicrobial composition contains (a) alcohol, (b) organic acid, (c) paraben, and (d) a redox compound. . The method of claim 1, wherein the antimicrobial composition comprises from about 1.5% to about 15% by weight of citric acid, from 0.01% to about 1% by weight of paraben, and from about 0.01% to about 0.2% by weight of the redox compound. 3. The method of claim 1, wherein the alcohol is ethanol, isopropyl alcohol, n-propanol, or a mixture thereof. The method of claim 1, wherein the composition comprises methylparaben in a concentration of from about 0.1% to about 0.4% by weight and propylparaben in a concentration of from about 0.01% to about 0.2% by weight. The method of claim 1, wherein the composition comprises from about 0.03% to about 0.12% by weight of methylene blue. The method of claim 1, wherein the composition comprises from about 4% to about 8% by weight of citric acid. The method of claim 1, wherein the composition comprises from about 0.2% to about 0.9% by weight of citrate salt. The method of claim 1, wherein the composition comprises (a) ethanol, isopropyl alcohol, n-propanol, or a mixture thereof, (b) citric acid in a concentration of from about 4% to about 8% by weight, (c) methylene blue in a concentration from about 0.03% to about 0.09% by weight, (d) methylparaben in a concentration of from about 0.1 to about 0.4% by weight, (e) propylparaben in a concentration of from about 0.01% to 0.2 % by weight, and (f) sodium citrate at a concentration of approx

Claims (17)

1. Способ дезинфекции поверхности кожи, включающий нанесение антимикробной композиции на поверхность кожи пациента, которая нуждается в дезинфекции, где антимикробная композиция содержит (а) спирт, (b) органическую кислоту, (с) парабен и (d) окислительно-восстановительное соединение.1. A method of disinfecting a skin surface, comprising applying an antimicrobial composition to a patient’s skin surface that needs to be disinfected, wherein the antimicrobial composition contains (a) alcohol, (b) organic acid, (c) paraben, and (d) a redox compound. 2. Способ по п. 1, где антимикробная композиция содержит приблизительно от 1,5% до приблизительно 15% по массе лимонной кислоты, от 0,01% до приблизительно 1% по массе парабена и приблизительно от 0,01% до приблизительно 0,2% по массе окислительно-восстановительного соединения.2. The method according to p. 1, where the antimicrobial composition contains from about 1.5% to about 15% by weight of citric acid, from 0.01% to about 1% by weight of paraben and from about 0.01% to about 0, 2% by weight of a redox compound. 3. Способ по п. 1, где спирт представляет собой этанол, изопропиловый спирт, н-пропанол, или их смесь.3. The method of claim 1, wherein the alcohol is ethanol, isopropyl alcohol, n-propanol, or a mixture thereof. 4. Способ по п. 1, где композиция содержит метилпарабен в концентрации приблизительно от 0,1% до приблизительно 0,4% по массе и пропилпарабен в концентрации приблизительно от 0,01% до приблизительно 0,2% по массе.4. The method of claim 1, wherein the composition comprises methylparaben at a concentration of from about 0.1% to about 0.4% by weight and propylparaben at a concentration of from about 0.01% to about 0.2% by weight. 5. Способ по п. 1, где композиция содержит приблизительно от 0,03% до приблизительно 0,12% по массе метиленового синего.5. The method of claim 1, wherein the composition comprises from about 0.03% to about 0.12% by weight of methylene blue. 6. Способ по п. 1, где композиция содержит приблизительно от 4% до приблизительно 8% по массе лимонной кислоты.6. The method of claim 1, wherein the composition comprises from about 4% to about 8% by weight of citric acid. 7. Способ по п. 1, где композиция содержит приблизительно от 0,2% до приблизительно 0,9% по массе цитратной соли.7. The method according to p. 1, where the composition contains from about 0.2% to about 0.9% by weight of citrate salt. 8. Способ по п. 1, где композиция содержит (а) этанол, изопропиловый спирт, н-пропанол, или их смесь, (b) лимонную кислоту в концентрации приблизительно от 4% до приблизительно 8% по массе, (с) метиленовый синий в концентрации приблизительно от 8. The method according to claim 1, where the composition contains (a) ethanol, isopropyl alcohol, n-propanol, or a mixture thereof, (b) citric acid in a concentration of from about 4% to about 8% by weight, (c) methylene blue at a concentration of approximately 0,03% до приблизительно 0,09 % по массе, (d) метилпарабена в концентрации приблизительно от 0,1 до приблизительно 0,4% по массе, (е) пропилпарабен в концентрации приблизительно от 0,01% до 0,2% по массе, и (f) цитрат натрия в концентрации приблизительно от 0,2% до приблизительно 0,9% по массе.0.03% to about 0.09% by weight, (d) methylparaben at a concentration of from about 0.1 to about 0.4% by weight, (e) propylparaben at a concentration of from about 0.01% to 0.2% by weight, and (f) sodium citrate in a concentration of from about 0.2% to about 0.9% by weight. 9. Способ по п. 1, где композиция имеет рН приблизительно от 3 до приблизительно 7.9. The method of claim 1, wherein the composition has a pH of from about 3 to about 7. 10. Способ по п. 1, где композиция содержится внутри аппликатора, включающего адсорбирующий материал.10. The method of claim 1, wherein the composition is contained within an applicator comprising adsorbent material. 11. Способ по п. 1, где аппликатор включает рукоятку с камерой для размещения антимикробной композиции и аппликатор, сформированный из адсорбирующего материала, подвижно соединенный с рукояткой.11. The method according to p. 1, where the applicator includes a handle with a camera for placement of the antimicrobial composition and an applicator formed of absorbent material, movably connected to the handle. 12. Способ по п. 1, где поверхностью кожи является поверхность с открытой раной мягких тканей.12. The method according to p. 1, where the surface of the skin is a surface with an open wound of soft tissues. 13. Способ по п. 1, где поверхностью кожи является поверхность слизистой оболочки.13. The method according to p. 1, where the surface of the skin is the surface of the mucous membrane. 14. Способ по п. 1, где нанесение включает очищение поверхности кожи антимикробной композицией в течение до шестидесяти секунд.14. The method of claim 1, wherein the application comprises cleansing the skin surface with an antimicrobial composition for up to sixty seconds. 15. Способ по п. 1, дополнительно включающий нагревание антимикробной композиции до нанесения композиции на поверхность кожи.15. The method according to p. 1, further comprising heating the antimicrobial composition before applying the composition to the skin surface. 16. Способ дезинфекции хирургического инструмента, включающий погружение хирургического инструмента в антимикробную композицию, содержащую (а) спирт, (b) органическую кислоту, (с) парабен и (d) окислительно-восстановительное соединение.16. A method for disinfecting a surgical instrument, comprising immersing the surgical instrument in an antimicrobial composition containing (a) alcohol, (b) organic acid, (c) paraben, and (d) a redox compound. 17. Применение композиции, содержащей (а) спирт, (b) органическую кислоту, (с) парабен и (d) окислительно-восстановительное соединение для получения лекарственного средства для дезинфекции поверхности кожи. 17. The use of a composition comprising (a) alcohol, (b) an organic acid, (c) paraben, and (d) a redox compound for the manufacture of a medicament for disinfecting a skin surface.
RU2014111445A 2008-05-23 2014-03-25 Antimicrobial compositions and methods of use RU2648456C2 (en)

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