CN106983740A - A kind of surface of a wound anesthesia lotion and preparation method thereof - Google Patents

A kind of surface of a wound anesthesia lotion and preparation method thereof Download PDF

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Publication number
CN106983740A
CN106983740A CN201710358634.8A CN201710358634A CN106983740A CN 106983740 A CN106983740 A CN 106983740A CN 201710358634 A CN201710358634 A CN 201710358634A CN 106983740 A CN106983740 A CN 106983740A
Authority
CN
China
Prior art keywords
wound
lotion
anesthesia
solution
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201710358634.8A
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Chinese (zh)
Inventor
朱颉
吴浩
黄都平
陆福鼎
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sun Yat Sen Memorial Hospital Sun Yat Sen University
Original Assignee
Sun Yat Sen Memorial Hospital Sun Yat Sen University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sun Yat Sen Memorial Hospital Sun Yat Sen University filed Critical Sun Yat Sen Memorial Hospital Sun Yat Sen University
Priority to CN201710358634.8A priority Critical patent/CN106983740A/en
Publication of CN106983740A publication Critical patent/CN106983740A/en
Pending legal-status Critical Current

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245Amino benzoic acid types, e.g. procaine, novocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/135Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/155Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions

Abstract

The invention belongs to clinical medicine technical field, a kind of surface of a wound anesthesia lotion and preparation method thereof is disclosed, surface of a wound anesthesia lotion is made up of 1 milligram of 30 grams of tetracaine hydrochloride, 50 milligrams of chlorhexidine gluconate and adrenalin hydrochloride;Preparation Method includes:Take 30 grams of tetracaine hydrochloride to be dissolved in 1000 milliliters of distilled water, be configured to solution A;50 milligrams of addition solution As of glucose Chlorhexidine are taken, solution B is formed;Take 1 milligram of adrenalin hydrochloride to add in solution B, stir evenly;Surface of a wound anesthesia lotion described in surface of a wound anesthesia lotion is made.The present invention cleaning surface of a wound, hemostasis, the step of local anaesthesia one are completed, and are taken less than 3 minutes, and 68 minutes average time limits than the clinical cleaning surface of a wound at present substantially shorten;In the wild or before institute can the self-cleaning surface of a wound, timely attenuating trauma surface infestation probability;Surface of a wound cleaning process comprising haemostatic effect, effectively reduces bleeding lesions simultaneously, with the obvious advantage to severe contamination and the bleeding surface of a wound.

Description

A kind of surface of a wound anesthesia lotion and preparation method thereof
Technical field
Lotion and preparation method thereof is anaesthetized the invention belongs to clinical medicine technical field, more particularly to a kind of surface of a wound.
Background technology
Human body after skin soft tissue lacerated wound, it is necessary to row debridement and suturing, local anaesthesia often after cleaning a wound Implement.Therefore patient can bear the great pain during cleaning wound again.
In summary, the problem of prior art is present be:The pain that many patients bring after wound to sterilization wound is bright Aobvious refusal, teenage or drunk patient can not coordinate completion cleaning surface of a wound process;In anesthesia set-up procedure, the surface of a wound continues Blood, no effective prevention measure;Most of patient is difficult to the pain for standing subcutaneous infiltration anesthesia.
The content of the invention
The problem of existing for prior art, the invention provides a kind of surface of a wound anesthesia lotion and preparation method thereof.
The present invention is achieved in that a kind of surface of a wound anesthesia lotion, the surface of a wound anesthesia lotion by 30 grams of tetracaine hydrochloride, 1 milligram of composition of 50 milligrams of chlorhexidine gluconate and adrenalin hydrochloride.
Further, the sprinkling of surface of a wound anesthesia lotion or soak are in wound surface, or surrounding skin.
A kind of preparation method of surface of a wound anesthesia lotion of another object of the present invention includes:
Take 30 grams of tetracaine hydrochloride to be dissolved in 1000 milliliters of distilled water, be configured to solution A;
50 milligrams of addition solution As of glucose Chlorhexidine are taken, solution B is formed;
Take 1 milligram of adrenalin hydrochloride to add in solution B, stir evenly;Surface of a wound anesthesia lotion is made.
Advantages of the present invention and good effect are:
1) present invention cleaning surface of a wound, hemostasis, the step of local anaesthesia one are completed, and are taken less than 3 minutes, than clinical cleaning wound at present Substantially shorten average time limit 6-8 minutes of face;
2) in the wild or before institute can the self-cleaning surface of a wound, timely attenuating trauma surface infestation probability;
3) surface of a wound cleaning process effectively reduces bleeding lesions, to severe contamination and the bleeding surface of a wound simultaneously comprising haemostatic effect It is with the obvious advantage;
4) the local anaesthesia time is about more than 1 hour, is significantly better than the half an hour of current lidocaine local infiltration anesthesia, It is easy to as patient and doctor's receiving.
5) pharmaceutical properties are stable, and normal temperature storage was up to more than 5 years;It is with low cost, can be direct by taking small debridement and suturing as an example Save medical expense more than 40%.
Brief description of the drawings
Fig. 1 is the preparation method flow chart that the surface of a wound provided in an embodiment of the present invention anaesthetizes lotion.
Embodiment
In order to make the purpose , technical scheme and advantage of the present invention be clearer, with reference to embodiments, to the present invention It is further elaborated.It should be appreciated that the specific embodiments described herein are merely illustrative of the present invention, it is not used to Limit the present invention.
The application principle of the present invention is explained in detail below in conjunction with the accompanying drawings.
The surface of a wound provided in an embodiment of the present invention anaesthetizes lotion, and the surface of a wound anaesthetizes lotion by 30 grams of tetracaine hydrochloride, grape 1 milligram of composition of 50 milligrams of saccharic acid Chlorhexidine and adrenalin hydrochloride.
The sprinkling of surface of a wound anesthesia lotion or soak are in wound surface, or surrounding skin.
As shown in figure 1, the preparation method of surface of a wound anesthesia lotion provided in an embodiment of the present invention includes:
S101:Take 30 grams of tetracaine hydrochloride to be dissolved in 1000 milliliters of distilled water, be configured to solution A;
S102:50 milligrams of addition solution As of glucose Chlorhexidine are taken, solution B is formed;
S103:Take 1 milligram of adrenalin hydrochloride to add in solution B, stir evenly;Surface of a wound anesthesia lotion is made.
The present invention cleaning surface of a wound, hemostasis, the step of local anaesthesia one are completed, and are taken less than 3 minutes, than the clinical cleaning surface of a wound at present Average time limit 6-8 minutes substantially shorten;In the wild or before institute can the self-cleaning surface of a wound, timely attenuating trauma surface infestation probability;Wound Face cleaning process comprising haemostatic effect, effectively reduces bleeding lesions simultaneously, with the obvious advantage to severe contamination and the bleeding surface of a wound;It is local Anesthesia duration is about more than 1 hour, is significantly better than the half an hour of current lidocaine local infiltration anesthesia, it is easy to be patient and doctor Teacher receives.The pharmaceutical properties are stable, and normal temperature storage was up to more than 5 years;It is with low cost, by taking small debridement and suturing as an example, can directly it save About medical expense more than 40%.
The sprinkling of surface of a wound anesthesia lotion or soak provided in an embodiment of the present invention are in wound surface, or surrounding skin, in short-term Interior (being preferred in 3 minutes), is fully achieved anesthesia or analgesic effect, and action time is kept at least more than 1 hour.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention Any modifications, equivalent substitutions and improvements made within refreshing and principle etc., should be included in the scope of the protection.

Claims (3)

1. a kind of surface of a wound anaesthetizes lotion, it is characterised in that the surface of a wound anaesthetizes lotion by 30 grams of tetracaine hydrochloride, gluconic acid chlorine Oneself determines 50 milligrams and 1 milligram of composition of adrenalin hydrochloride.
2. the surface of a wound as claimed in claim 1 anaesthetizes lotion, it is characterised in that the sprinkling of surface of a wound anesthesia lotion or soak are in wound The mouth surface of a wound, or surrounding skin.
3. a kind of surface of a wound as claimed in claim 1 anaesthetizes the preparation method of lotion, it is characterised in that the surface of a wound anesthesia lotion Preparation method includes:
Take 30 grams of tetracaine hydrochloride to be dissolved in 1000 milliliters of distilled water, be configured to solution A;
50 milligrams of addition solution As of glucose Chlorhexidine are taken, solution B is formed;
Take 1 milligram of adrenalin hydrochloride to add in solution B, stir evenly;Surface of a wound anesthesia lotion is made.
CN201710358634.8A 2017-05-19 2017-05-19 A kind of surface of a wound anesthesia lotion and preparation method thereof Pending CN106983740A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201710358634.8A CN106983740A (en) 2017-05-19 2017-05-19 A kind of surface of a wound anesthesia lotion and preparation method thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201710358634.8A CN106983740A (en) 2017-05-19 2017-05-19 A kind of surface of a wound anesthesia lotion and preparation method thereof

Publications (1)

Publication Number Publication Date
CN106983740A true CN106983740A (en) 2017-07-28

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201710358634.8A Pending CN106983740A (en) 2017-05-19 2017-05-19 A kind of surface of a wound anesthesia lotion and preparation method thereof

Country Status (1)

Country Link
CN (1) CN106983740A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111494310A (en) * 2020-04-29 2020-08-07 周晓玲 Preparation and application method of local anesthetic
RU2774622C1 (en) * 2021-05-14 2022-06-21 Александр Витальевич Ляхович Antiseptic combination, antiseptic pharmaceutical composition and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1161528A (en) * 1967-05-18 1969-08-13 Prebbles Medical Ltd Improvements in or relating to Surgical Dressings
CN1093897A (en) * 1993-04-22 1994-10-26 孟丽君 The preparation method of surface anesthesia film

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1161528A (en) * 1967-05-18 1969-08-13 Prebbles Medical Ltd Improvements in or relating to Surgical Dressings
CN1093897A (en) * 1993-04-22 1994-10-26 孟丽君 The preparation method of surface anesthesia film

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111494310A (en) * 2020-04-29 2020-08-07 周晓玲 Preparation and application method of local anesthetic
RU2774622C1 (en) * 2021-05-14 2022-06-21 Александр Витальевич Ляхович Antiseptic combination, antiseptic pharmaceutical composition and application thereof

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Application publication date: 20170728