RU2012108048A - Лечение вирусных инфекций - Google Patents
Лечение вирусных инфекций Download PDFInfo
- Publication number
- RU2012108048A RU2012108048A RU2012108048/04A RU2012108048A RU2012108048A RU 2012108048 A RU2012108048 A RU 2012108048A RU 2012108048/04 A RU2012108048/04 A RU 2012108048/04A RU 2012108048 A RU2012108048 A RU 2012108048A RU 2012108048 A RU2012108048 A RU 2012108048A
- Authority
- RU
- Russia
- Prior art keywords
- group
- amino
- compound
- chlorophenyl
- compound according
- Prior art date
Links
- 208000036142 Viral infection Diseases 0.000 title claims 9
- 150000001875 compounds Chemical class 0.000 claims abstract 43
- 125000001424 substituent group Chemical group 0.000 claims abstract 12
- 125000000217 alkyl group Chemical group 0.000 claims abstract 7
- 229910052736 halogen Inorganic materials 0.000 claims abstract 6
- 150000002367 halogens Chemical class 0.000 claims abstract 6
- 125000003545 alkoxy group Chemical group 0.000 claims abstract 5
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 5
- 125000003277 amino group Chemical group 0.000 claims abstract 4
- 229910052799 carbon Inorganic materials 0.000 claims abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 4
- 125000005842 heteroatom Chemical group 0.000 claims abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims abstract 3
- 150000001721 carbon Chemical group 0.000 claims abstract 3
- 125000004429 atom Chemical group 0.000 claims abstract 2
- 125000004122 cyclic group Chemical group 0.000 claims abstract 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims abstract 2
- 230000009385 viral infection Effects 0.000 claims 9
- DJSNHTLVPYKCPO-UHFFFAOYSA-N 1-amino-1-(3-chlorophenyl)-2,3,3-trimethylbutan-1-ol Chemical compound CC(C)(C)C(C(O)(C1=CC(=CC=C1)Cl)N)C DJSNHTLVPYKCPO-UHFFFAOYSA-N 0.000 claims 8
- UAGZZBXHLITKME-UHFFFAOYSA-N 2-amino-1-(3-chlorophenyl)-4-hydroxy-2,3,3-trimethylbutan-1-one Chemical compound OCC(C)(C)C(C)(N)C(=O)C1=CC=CC(Cl)=C1 UAGZZBXHLITKME-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims 4
- 241001529453 unidentified herpesvirus Species 0.000 claims 4
- 241000700588 Human alphaherpesvirus 1 Species 0.000 claims 3
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 230000001154 acute effect Effects 0.000 claims 3
- 229960001058 bupropion Drugs 0.000 claims 3
- 208000015181 infectious disease Diseases 0.000 claims 3
- 230000000116 mitigating effect Effects 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 208000009889 Herpes Simplex Diseases 0.000 claims 2
- 241000282414 Homo sapiens Species 0.000 claims 2
- 241000701074 Human alphaherpesvirus 2 Species 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 239000000048 adrenergic agonist Substances 0.000 claims 2
- 229940126157 adrenergic receptor agonist Drugs 0.000 claims 2
- 102000016966 beta-2 Adrenergic Receptors Human genes 0.000 claims 2
- 108010014499 beta-2 Adrenergic Receptors Proteins 0.000 claims 2
- LMOINURANNBYCM-UHFFFAOYSA-N metaproterenol Chemical compound CC(C)NCC(O)C1=CC(O)=CC(O)=C1 LMOINURANNBYCM-UHFFFAOYSA-N 0.000 claims 2
- -1 optionally having OH Chemical group 0.000 claims 2
- 229960002657 orciprenaline Drugs 0.000 claims 2
- XWTYSIMOBUGWOL-UHFFFAOYSA-N (+-)-Terbutaline Chemical compound CC(C)(C)NCC(O)C1=CC(O)=CC(O)=C1 XWTYSIMOBUGWOL-UHFFFAOYSA-N 0.000 claims 1
- SSJXIUAHEKJCMH-WDSKDSINSA-N (1s,2s)-cyclohexane-1,2-diamine Chemical compound N[C@H]1CCCC[C@@H]1N SSJXIUAHEKJCMH-WDSKDSINSA-N 0.000 claims 1
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- NDAUXUAQIAJITI-LBPRGKRZSA-N (R)-salbutamol Chemical compound CC(C)(C)NC[C@H](O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-LBPRGKRZSA-N 0.000 claims 1
- UYNVMODNBIQBMV-UHFFFAOYSA-N 4-[1-hydroxy-2-[4-(phenylmethyl)-1-piperidinyl]propyl]phenol Chemical compound C1CC(CC=2C=CC=CC=2)CCN1C(C)C(O)C1=CC=C(O)C=C1 UYNVMODNBIQBMV-UHFFFAOYSA-N 0.000 claims 1
- LSLYOANBFKQKPT-DIFFPNOSSA-N 5-[(1r)-1-hydroxy-2-[[(2r)-1-(4-hydroxyphenyl)propan-2-yl]amino]ethyl]benzene-1,3-diol Chemical compound C([C@@H](C)NC[C@H](O)C=1C=C(O)C=C(O)C=1)C1=CC=C(O)C=C1 LSLYOANBFKQKPT-DIFFPNOSSA-N 0.000 claims 1
- 201000006082 Chickenpox Diseases 0.000 claims 1
- 241000701022 Cytomegalovirus Species 0.000 claims 1
- JRWZLRBJNMZMFE-UHFFFAOYSA-N Dobutamine Chemical compound C=1C=C(O)C(O)=CC=1CCNC(C)CCC1=CC=C(O)C=C1 JRWZLRBJNMZMFE-UHFFFAOYSA-N 0.000 claims 1
- 208000007514 Herpes zoster Diseases 0.000 claims 1
- 241000701044 Human gammaherpesvirus 4 Species 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000713196 Influenza B virus Species 0.000 claims 1
- 241000713297 Influenza C virus Species 0.000 claims 1
- 102100037850 Interferon gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 241000699666 Mus <mouse, genus> Species 0.000 claims 1
- VQDBNKDJNJQRDG-UHFFFAOYSA-N Pirbuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=N1 VQDBNKDJNJQRDG-UHFFFAOYSA-N 0.000 claims 1
- GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 206010046980 Varicella Diseases 0.000 claims 1
- NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical group CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229960003060 bambuterol Drugs 0.000 claims 1
- ANZXOIAKUNOVQU-UHFFFAOYSA-N bambuterol Chemical compound CN(C)C(=O)OC1=CC(OC(=O)N(C)C)=CC(C(O)CNC(C)(C)C)=C1 ANZXOIAKUNOVQU-UHFFFAOYSA-N 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 229960000585 bitolterol mesylate Drugs 0.000 claims 1
- HODFCFXCOMKRCG-UHFFFAOYSA-N bitolterol mesylate Chemical compound CS([O-])(=O)=O.C1=CC(C)=CC=C1C(=O)OC1=CC=C(C(O)C[NH2+]C(C)(C)C)C=C1OC(=O)C1=CC=C(C)C=C1 HODFCFXCOMKRCG-UHFFFAOYSA-N 0.000 claims 1
- 125000005708 carbonyloxy group Chemical group [*:2]OC([*:1])=O 0.000 claims 1
- 230000016396 cytokine production Effects 0.000 claims 1
- 229960001089 dobutamine Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000005713 exacerbation Effects 0.000 claims 1
- 229960001022 fenoterol Drugs 0.000 claims 1
- 229960002848 formoterol Drugs 0.000 claims 1
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 1
- 229960003998 ifenprodil Drugs 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 229950008204 levosalbutamol Drugs 0.000 claims 1
- 239000002207 metabolite Substances 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960005414 pirbuterol Drugs 0.000 claims 1
- IOVGROKTTNBUGK-SJCJKPOMSA-N ritodrine Chemical compound N([C@@H](C)[C@H](O)C=1C=CC(O)=CC=1)CCC1=CC=C(O)C=C1 IOVGROKTTNBUGK-SJCJKPOMSA-N 0.000 claims 1
- 229960001634 ritodrine Drugs 0.000 claims 1
- 229960002052 salbutamol Drugs 0.000 claims 1
- 229960004017 salmeterol Drugs 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 229960000195 terbutaline Drugs 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 1
- 230000001055 chewing effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0913914A GB0913914D0 (en) | 2009-08-10 | 2009-08-10 | Treatment of viral infections |
| GB0913914.8 | 2009-08-10 | ||
| GBGB1001821.6A GB201001821D0 (en) | 2010-02-04 | 2010-02-04 | Treatment of viral infections |
| GB1001821.6 | 2010-02-04 | ||
| GB1012168.9 | 2010-07-20 | ||
| GB1012168A GB2477584A (en) | 2010-02-04 | 2010-07-20 | A compound for use in treating an acute viral infection |
| PCT/GB2010/051317 WO2011018653A2 (en) | 2009-08-10 | 2010-08-10 | Treatment of viral infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012108048A true RU2012108048A (ru) | 2013-09-20 |
Family
ID=43063293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012108048/04A RU2012108048A (ru) | 2009-08-10 | 2010-08-10 | Лечение вирусных инфекций |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120283334A1 (enExample) |
| EP (1) | EP2464345A2 (enExample) |
| JP (1) | JP2013501770A (enExample) |
| CN (1) | CN102497860A (enExample) |
| AU (1) | AU2010283583A1 (enExample) |
| IN (1) | IN2012DN02123A (enExample) |
| RU (1) | RU2012108048A (enExample) |
| SG (1) | SG178345A1 (enExample) |
| WO (1) | WO2011018653A2 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108721262A (zh) * | 2017-04-13 | 2018-11-02 | 中国科学院武汉病毒研究所 | 安非他酮在制备治疗或预防流感病毒感染的药物中的应用 |
| CN115068453A (zh) * | 2021-03-15 | 2022-09-20 | 中国医学科学院药物研究所 | 沙美特罗防治流感的药物用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE295159T1 (de) * | 1998-12-08 | 2005-05-15 | Planisphere Corp | Bupropion zur behandlung von viralen erkrankungen |
| US20060173080A1 (en) * | 2002-09-14 | 2006-08-03 | The Regents Of The University Of California | Methods of modulating TNF using bupropion |
| DE102004063132A1 (de) * | 2004-12-22 | 2006-07-06 | Schmiegel, Wolff, Prof. Dr. | Verwendung von Bupropion in Arzneimittel zur Behandlung von Hepatitis C |
-
2010
- 2010-08-10 AU AU2010283583A patent/AU2010283583A1/en not_active Abandoned
- 2010-08-10 CN CN2010800404927A patent/CN102497860A/zh active Pending
- 2010-08-10 JP JP2012524290A patent/JP2013501770A/ja active Pending
- 2010-08-10 SG SG2012009197A patent/SG178345A1/en unknown
- 2010-08-10 IN IN2123DEN2012 patent/IN2012DN02123A/en unknown
- 2010-08-10 EP EP10743209A patent/EP2464345A2/en not_active Withdrawn
- 2010-08-10 WO PCT/GB2010/051317 patent/WO2011018653A2/en not_active Ceased
- 2010-08-10 US US13/390,040 patent/US20120283334A1/en not_active Abandoned
- 2010-08-10 RU RU2012108048/04A patent/RU2012108048A/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2464345A2 (en) | 2012-06-20 |
| IN2012DN02123A (enExample) | 2015-08-21 |
| WO2011018653A2 (en) | 2011-02-17 |
| SG178345A1 (en) | 2012-03-29 |
| CN102497860A (zh) | 2012-06-13 |
| WO2011018653A3 (en) | 2011-04-07 |
| JP2013501770A (ja) | 2013-01-17 |
| AU2010283583A1 (en) | 2012-03-08 |
| US20120283334A1 (en) | 2012-11-08 |
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