RU2010146281A - BACTERIA OF THE GENUS Escherichia Possessing Enhanced Expression of the ACEEF-lpdA GENES OPERON AND METHOD FOR PRODUCING SUITIC ACID USING SUCH BACTERIA - Google Patents
BACTERIA OF THE GENUS Escherichia Possessing Enhanced Expression of the ACEEF-lpdA GENES OPERON AND METHOD FOR PRODUCING SUITIC ACID USING SUCH BACTERIA Download PDFInfo
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- RU2010146281A RU2010146281A RU2010146281/10A RU2010146281A RU2010146281A RU 2010146281 A RU2010146281 A RU 2010146281A RU 2010146281/10 A RU2010146281/10 A RU 2010146281/10A RU 2010146281 A RU2010146281 A RU 2010146281A RU 2010146281 A RU2010146281 A RU 2010146281A
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- aceef
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Abstract
1. Бактерия рода Escherichia - продуцент янтарной кислоты, модифицированая таким образом, что экспрессия генов aceEF-lpdA оперона в указанной бактерии усилена. ! 2. Бактерия по п.1 отличающаяся тем, что указанная экспрессия усилена за счет модификации последовательности, контролирующей экспрессию генов aceEF-lpdA оперона. ! 3. Бактерия по п.1, отличающаяся тем, что указанная бактерия принадлежит к виду Escherichia coli. ! 4. Бактерия по п.1, отличающаяся тем, что указанная бактерия дополнительно модифицирована таким образом, что приобретает активность пируваткарбоксилазы. ! 5. Бактерия по п.4, отличающаяся тем, что активность пируваткарбоксилазы обеспечивается присутствием в бактерии молекулы ДНК, содержащей ген, кодирующий пируваткарбоксилазу. ! 6. Способ получения янтарной кислоты, включающий стадии культивирования бактерии по любому из пп.1-5 в питательной среде и выделения янтарной кислоты из культуральной жидкости. ! 7. Способ по п.6, отличающийся тем, что процесс культивирования бактерии включает в себя аэробную стадию накопления биомассы и анаэробную стадию продукции янтарной кислоты. 1. A bacterium of the genus Escherichia is a producer of succinic acid, modified in such a way that the expression of the aceEF-lpdA operon genes in the specified bacterium is enhanced. ! 2. The bacterium according to claim 1, characterized in that said expression is enhanced by modifying the sequence that controls the expression of the aceEF-lpdA operon genes. ! 3. The bacterium according to claim 1, characterized in that said bacterium belongs to the species Escherichia coli. ! 4. The bacterium according to claim 1, characterized in that said bacterium is further modified in such a way that it acquires pyruvate carboxylase activity. ! 5. The bacterium according to claim 4, characterized in that the activity of pyruvate carboxylase is ensured by the presence in the bacterium of a DNA molecule containing a gene encoding pyruvate carboxylase. ! 6. A method for producing succinic acid, comprising the steps of culturing the bacterium according to any one of claims 1 to 5 in a nutrient medium and isolating succinic acid from the culture fluid. ! 7. The method according to claim 6, characterized in that the bacterial cultivation process includes the aerobic stage of biomass accumulation and the anaerobic stage of succinic acid production.
Claims (7)
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RU2010146281/10A RU2466186C2 (en) | 2010-11-13 | 2010-11-13 | BACTERIUM Escherichia coli - SUCCINIC ACID PRODUCER AND METHOD FOR PREPARING SUCCINIC ACID |
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RU2010146281/10A RU2466186C2 (en) | 2010-11-13 | 2010-11-13 | BACTERIUM Escherichia coli - SUCCINIC ACID PRODUCER AND METHOD FOR PREPARING SUCCINIC ACID |
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RU2010146281A true RU2010146281A (en) | 2012-05-20 |
RU2466186C2 RU2466186C2 (en) | 2012-11-10 |
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RU2010146281/10A RU2466186C2 (en) | 2010-11-13 | 2010-11-13 | BACTERIUM Escherichia coli - SUCCINIC ACID PRODUCER AND METHOD FOR PREPARING SUCCINIC ACID |
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Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2528056C2 (en) * | 2012-10-19 | 2014-09-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") | RECOMBINANT BACTERIAL STRAIN Escherichia coli THAT IS SUCCINIC ACID PRODUCER (VERSIONS) AND METHOD FOR PREPARING SUCCINIC ACID WITH USING THIS STRAIN |
CN113373164A (en) * | 2021-06-01 | 2021-09-10 | 华东理工大学 | Ribosome site sequence of over-expressed pyruvate dehydrogenase complex and application thereof |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104178442B (en) * | 2013-05-24 | 2017-10-31 | 中国科学院天津工业生物技术研究所 | The Escherichia coli of lpdA genes containing mutation and its application |
CN104178443B (en) | 2013-05-24 | 2017-04-12 | 中国科学院天津工业生物技术研究所 | Recombinant escherichia coli producing succinic acid and application thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006020663A2 (en) * | 2004-08-09 | 2006-02-23 | Rice University | Aerobic succinate production in bacteria |
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2010
- 2010-11-13 RU RU2010146281/10A patent/RU2466186C2/en active
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2528056C2 (en) * | 2012-10-19 | 2014-09-10 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт генетики и селекции промышленных микроорганизмов" (ФГУП "ГосНИИгенетика") | RECOMBINANT BACTERIAL STRAIN Escherichia coli THAT IS SUCCINIC ACID PRODUCER (VERSIONS) AND METHOD FOR PREPARING SUCCINIC ACID WITH USING THIS STRAIN |
CN113373164A (en) * | 2021-06-01 | 2021-09-10 | 华东理工大学 | Ribosome site sequence of over-expressed pyruvate dehydrogenase complex and application thereof |
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RU2466186C2 (en) | 2012-11-10 |
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