RU2009141996A - ATF-BINDING CASSETTE MODULATORS - Google Patents
ATF-BINDING CASSETTE MODULATORS Download PDFInfo
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- RU2009141996A RU2009141996A RU2009141996/04A RU2009141996A RU2009141996A RU 2009141996 A RU2009141996 A RU 2009141996A RU 2009141996/04 A RU2009141996/04 A RU 2009141996/04A RU 2009141996 A RU2009141996 A RU 2009141996A RU 2009141996 A RU2009141996 A RU 2009141996A
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- alkyl
- optionally substituted
- compound
- nhc
- independently selected
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Abstract
1. Соединение формулы II ! ! II ! или его фармацевтически приемлемая соль, где: ! каждый из WRW2 и WRW4 независимо выбирают из -CN, -CF3, атома галогена, линейного или разветвленного (C2-C6)алкила, (C3-C12)-членной циклоалифатической группы, фенила, 5-10-членного гетероарила или 3-7-членной гетероциклической группы, где указанный гетероарил или указанная гетероциклическая группа имеет вплоть до 3 гетероатомов, выбранных из O, S или N, где указанные WRW2 и WRW4 независимо и необязательно замещены вплоть до трех заместителями, выбранными из -OR', -CF3, -OCF3, SR', S(O)R', SO2R', -SCF3, атома галогена, CN, -COOR', -COR', -O(CH2)2N(R')2, -O(CH2)N(R')2, -CON(R')2, -(CH2)2OR', -(CH2)OR', -CH2CN, необязательно замещенного фенила или феноксигруппы, -N(R')2, -NR'C(O)OR', -NR'C(O)R', -(CH2)2N(R')2 или -(CH2)N(R')2; ! WRW5 выбирают из водорода, -OCF3, -CF3, -OH, -OCH3, -NH2, -CN, -CHF2, -NHR', -N(R')2, -NHC(O)R', -NHC(O)OR', -NHSO2R', -CH2OH, -CH2N(R')2, -C(O)OR', -SO2NHR', -SO2N(R')2 или -CH2NHC(O)OR'; и ! каждый R' независимо выбирают из необязательно замещенной группы, выбранной из (C1-C8)алифатической группы, 3-8-членного насыщенного, частично ненасыщенного или полностью ненасыщенного моноциклического кольца, имеющего 0-3 гетероатома, независимо выбранных из атомов азота, кислорода или серы, или 8-12-членной насыщенной, частично ненасыщенной или полностью ненасыщенной бициклической кольцевой системы, имеющей 0-5 гетероатомов, независимо выбранных из атомов азота, кислорода или серы; или два имеющихся радикала R' вместе с атомом (атомами), с которым (которыми) они связаны, образуют необязательно замещенное 3-12-членное насыщенное, частично ненасыщенное или полностью ненасыщенное моноциклическое или бициклическое кольцо, имеющее 0-4 гетероатома, независимо выбранных из атомов азота, кислорода или серы; ! при услови 1. The compound of formula II! ! II! or its pharmaceutically acceptable salt, where:! each of WRW2 and WRW4 is independently selected from —CN, —CF3, a halogen atom, a linear or branched (C2-C6) alkyl, (C3-C12) membered cycloaliphatic group, phenyl, a 5-10 membered heteroaryl, or 3-7- a heterocyclic group, wherein said heteroaryl or said heterocyclic group has up to 3 heteroatoms selected from O, S or N, where said WRW2 and WRW4 are independently and optionally substituted with up to three substituents selected from -OR ', -CF3, -OCF3 , SR ', S (O) R', SO2R ', -SCF3, halogen atom, CN, -COOR', -COR ', -O (CH2) 2N (R') 2, -O (CH2) N (R ') 2, -CON (R') 2, - (CH2) 2OR ', - (CH2) OR', -CH2CN, optionally substituted phenyl or phenoxy groups, -N (R ') 2, -NR'C (O) OR', -NR'C (O) R ', - (CH2) 2N (R') 2 or - (CH2) N ( R ') 2; ! WRW5 is selected from hydrogen, —OCF3, —CF3, —OH, —OCH3, —NH2, —CN, —CHF2, —NHR ′, —N (R ′) 2, —NHC (O) R ′, —NHC (O ) OR ', -NHSO2R', -CH2OH, -CH2N (R ') 2, -C (O) OR', -SO2NHR ', -SO2N (R') 2 or -CH2NHC (O) OR '; and! each R ′ is independently selected from an optionally substituted group selected from a (C1-C8) aliphatic group, a 3-8 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur atoms or an 8-12 membered saturated, partially unsaturated or completely unsaturated bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen or sulfur atoms; or two existing radicals R 'together with the atom (s) to which they are bonded form an optionally substituted 3-12 membered saturated, partially unsaturated or completely unsaturated monocyclic or bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur atoms; ! under the condition
Claims (46)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58267604P | 2004-06-24 | 2004-06-24 | |
US60/582,676 | 2004-06-24 | ||
US63012704P | 2004-11-22 | 2004-11-22 | |
US60/630,127 | 2004-11-22 | ||
US63567404P | 2004-12-13 | 2004-12-13 | |
US60/635,674 | 2004-12-13 | ||
US65821905P | 2005-03-03 | 2005-03-03 | |
US60/658,219 | 2005-03-03 | ||
US66131105P | 2005-03-11 | 2005-03-11 | |
US60/661,311 | 2005-03-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2007102578/04A Division RU2382779C2 (en) | 2004-06-24 | 2005-06-24 | Atp-binding casette transporter modulators |
Publications (2)
Publication Number | Publication Date |
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RU2009141996A true RU2009141996A (en) | 2011-05-20 |
RU2528046C2 RU2528046C2 (en) | 2014-09-10 |
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Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2009141996/04A RU2528046C2 (en) | 2004-06-24 | 2005-06-24 | Modulators of atp-binding cartridge transporters |
RU2009142030/04A RU2556984C2 (en) | 2004-06-24 | 2005-06-24 | Modulators of atp-binding cassette transporters |
RU2009142031/04A RU2525115C2 (en) | 2004-06-24 | 2005-06-24 | Method of modulating transporters of atp-binding cassette |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
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RU2009142030/04A RU2556984C2 (en) | 2004-06-24 | 2005-06-24 | Modulators of atp-binding cassette transporters |
RU2009142031/04A RU2525115C2 (en) | 2004-06-24 | 2005-06-24 | Method of modulating transporters of atp-binding cassette |
Country Status (1)
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RU (3) | RU2528046C2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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SG11201402765TA (en) | 2011-12-30 | 2014-06-27 | Hanmi Pharm Ind Co Ltd | THIENO[3,2-d]PYRIMIDINE DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASES |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3524858A (en) * | 1967-05-18 | 1970-08-18 | Warner Lambert Pharmaceutical | 1,4 - dihydro-1-substituted alkyl-6,7-methylenedioxy - 4 - oxoquinoline-3-carboxylic acid |
US3751406A (en) * | 1967-07-24 | 1973-08-07 | Polaroid Corp | Azo compounds useful in photographic processes |
US4110355A (en) * | 1972-12-26 | 1978-08-29 | Polaroid Corporation | Anthraquinone compounds useful in photographic processes |
GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
GB1433151A (en) * | 1973-04-05 | 1976-04-22 | Allen & Hanburys Ltd | Benzo-ij-quinolizines |
FR2340735A1 (en) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | NEW DERIVATIVES OF 3-QUINOLEINE CARBOXYLIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT |
SU1360584A3 (en) * | 1983-08-12 | 1987-12-15 | Варнер-Ламберт Компани (Фирма) | Method of producing naphthyrydine quinoline- or benzoxazine carbolic acids or their pharmaceutically acceptable salts of acid addition |
US4786644A (en) * | 1987-11-27 | 1988-11-22 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-quinolinecarboxamide |
DE3903799A1 (en) * | 1989-02-09 | 1990-08-16 | Bayer Ag | N-ARYL NITROGEN HETEROCYCLES |
AU696390B2 (en) * | 1995-08-02 | 1998-09-10 | Darwin Discovery Limited | Quinolones and their therapeutic use |
EP1652839A3 (en) * | 1999-10-28 | 2006-07-05 | Daiichi Pharmaceutical Co., Ltd. | Drug efflux pump inhibitor |
CN1191252C (en) * | 2003-08-11 | 2005-03-02 | 中国药科大学 | 3-position substituted quinolone derivativers and its use in pharmacy |
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2005
- 2005-06-24 RU RU2009141996/04A patent/RU2528046C2/en active
- 2005-06-24 RU RU2009142030/04A patent/RU2556984C2/en active
- 2005-06-24 RU RU2009142031/04A patent/RU2525115C2/en active
Also Published As
Publication number | Publication date |
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RU2009142031A (en) | 2011-05-20 |
RU2525115C2 (en) | 2014-08-10 |
RU2009142030A (en) | 2011-05-20 |
RU2556984C2 (en) | 2015-07-20 |
RU2528046C2 (en) | 2014-09-10 |
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