RU2009142030A - ATF-BINDING CASSETTE MODULATORS - Google Patents
ATF-BINDING CASSETTE MODULATORS Download PDFInfo
- Publication number
- RU2009142030A RU2009142030A RU2009142030/04A RU2009142030A RU2009142030A RU 2009142030 A RU2009142030 A RU 2009142030A RU 2009142030/04 A RU2009142030/04 A RU 2009142030/04A RU 2009142030 A RU2009142030 A RU 2009142030A RU 2009142030 A RU2009142030 A RU 2009142030A
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- Prior art keywords
- optionally substituted
- ring
- compound
- hydrogen atom
- alkyl
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- 0 C*(C)CCNCC(N(C)CC([n]1c2cc(C)ccc2cc1)=O)=O Chemical compound C*(C)CCNCC(N(C)CC([n]1c2cc(C)ccc2cc1)=O)=O 0.000 description 2
- ZOVQERQRCSNRJV-IHWYPQMZSA-N C/C=C\OC(N)(N)O Chemical compound C/C=C\OC(N)(N)O ZOVQERQRCSNRJV-IHWYPQMZSA-N 0.000 description 1
- BUDQDWGNQVEFAC-UHFFFAOYSA-N C1COC=CC1 Chemical compound C1COC=CC1 BUDQDWGNQVEFAC-UHFFFAOYSA-N 0.000 description 1
- QYEGNXQXGDOYCK-UHFFFAOYSA-N CC([n]1c2cc(C)ccc2cc1)=O Chemical compound CC([n]1c2cc(C)ccc2cc1)=O QYEGNXQXGDOYCK-UHFFFAOYSA-N 0.000 description 1
Abstract
1. Соединение формулы (I) !! или его фармацевтически приемлемая соль, где ! Ar1 означает 5-6-членное ароматическое моноциклическое кольцо, имеющее 0-4 гетероатома, независимо выбранных из атомов азота, кислорода или серы, где вышеуказанное кольцо необязательно конденсировано с 5-12-членным моноциклическим или бициклическим, ароматическим, частично ненасыщенным или насыщенным кольцом, где каждое кольцо содержит 0-4 гетероатома, независимо выбранных из атомов азота, кислорода или серы, где Ar1 имеет m заместителей, каждый, независимо выбранный из -WRW; ! W означает связь или необязательно замещенную (С1-С6)алкилиденовую цепь, где вплоть до двух метиленовых групп остатка W необязательно и независимо заменены на -СО-, -CS-, -COCO-, -CONR'-, -CONR'NR', -CO2-, -OCO-, -NR'CO2-, -O-, -NR'CONR'-, -ОCОNR'-, -NR'NR'-, -NR'NR'CO-, -NR'CO-, -S-, -SO-, -SO2-, -NR'-, -SO2NR'-, -NR'SO2-, -NR'SO2NR'-; ! RW независимо означает R', атом галогена, NO2, CN, CF3 или OCF3; ! m равен 0-5; ! каждый из R1, R2, R3, R4 и R5 независимо означает -Х-RX; ! Х означает связь или необязательно замещенную (С1-С6)алкилиденовую цепь, где вплоть до двух метиленовых групп остатка Х необязательно и независимо заменены на -СО-, -CS-, -COCO-, -CONR'-, -CONR'NR', -CO2-, -OCO-, -NR'CO2-, -O-, -NR'CONR'-, -ОCОNR'-, -NR'NR'-, -NR'NR'CO-, -NR'CO-, -S-, -SO-, -SO2-, -NR'-, -SO2NR'-, -NR'SO2- или -NR'SO2NR'-; ! RX независимо означает R', атом галогена, NO2, CN, CF3 или OCF3; ! R6 означает атом водорода, CF3, -OR', -SR' или необязательно замещенную (С1-С8)алифатическую группу; !R7 означает атом водорода или (С1-С6)алифатическую группу, необязательно замещенную группой -Х-RХ; ! R' независимо выбирают из атома водорода или необязательно замещенной группы, выбранной из (С1-С8)алифатической группы, 3-8-членного насыщенного, частично ненасыщенного или полностью ненасыщенного моноциклич 1. The compound of formula (I) !! or its pharmaceutically acceptable salt, where! Ar1 means a 5-6 membered aromatic monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur atoms, wherein the above ring is optionally fused to a 5-12 membered monocyclic or bicyclic, aromatic, partially unsaturated or saturated ring, where each ring contains 0-4 heteroatoms independently selected from nitrogen, oxygen or sulfur atoms, where Ar1 has m substituents, each independently selected from -WRW; ! W means a bond or an optionally substituted (C1-C6) alkylidene chain, where up to two methylene groups of the W residue are optionally and independently replaced by -CO-, -CS-, -COCO-, -CONR'-, -CONR'NR ', -CO2-, -OCO-, -NR'CO2-, -O-, -NR'CONR'-, -OCONR'-, -NR'NR'-, -NR'NR'CO-, -NR'CO- , -S-, -SO-, -SO2-, -NR'-, -SO2NR'-, -NR'SO2-, -NR'SO2NR'-; ! RW independently means R ', a halogen atom, NO2, CN, CF3 or OCF3; ! m is 0-5; ! each of R1, R2, R3, R4 and R5 independently means —X — RX; ! X means a bond or an optionally substituted (C1-C6) alkylidene chain, where up to two methylene groups of the X residue are optionally and independently replaced by -CO-, -CS-, -COCO-, -CONR'-, -CONR'NR ', -CO2-, -OCO-, -NR'CO2-, -O-, -NR'CONR'-, -OCONR'-, -NR'NR'-, -NR'NR'CO-, -NR'CO- , -S-, -SO-, -SO2-, -NR'-, -SO2NR'-, -NR'SO2- or -NR'SO2NR'-; ! RX independently means R ', a halogen atom, NO2, CN, CF3 or OCF3; ! R6 is a hydrogen atom, CF3, -OR ', -SR' or an optionally substituted (C1-C8) aliphatic group; ! R7 is a hydrogen atom or a (C1-C6) aliphatic group optionally substituted with a —X — RX group; ! R ′ is independently selected from a hydrogen atom or an optionally substituted group selected from a (C1-C8) aliphatic group, a 3-8 membered saturated, partially unsaturated or completely unsaturated monocyclic
Claims (75)
Applications Claiming Priority (10)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58267604P | 2004-06-24 | 2004-06-24 | |
US60/582,676 | 2004-06-24 | ||
US63012704P | 2004-11-22 | 2004-11-22 | |
US60/630,127 | 2004-11-22 | ||
US63567404P | 2004-12-13 | 2004-12-13 | |
US60/635,674 | 2004-12-13 | ||
US65821905P | 2005-03-03 | 2005-03-03 | |
US60/658,219 | 2005-03-03 | ||
US66131105P | 2005-03-11 | 2005-03-11 | |
US60/661,311 | 2005-03-11 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2007102578/04A Division RU2382779C2 (en) | 2004-06-24 | 2005-06-24 | Atp-binding casette transporter modulators |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2009142030A true RU2009142030A (en) | 2011-05-20 |
RU2556984C2 RU2556984C2 (en) | 2015-07-20 |
Family
ID=44733433
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2009142030/04A RU2556984C2 (en) | 2004-06-24 | 2005-06-24 | Modulators of atp-binding cassette transporters |
RU2009142031/04A RU2525115C2 (en) | 2004-06-24 | 2005-06-24 | Method of modulating transporters of atp-binding cassette |
RU2009141996/04A RU2528046C2 (en) | 2004-06-24 | 2005-06-24 | Modulators of atp-binding cartridge transporters |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2009142031/04A RU2525115C2 (en) | 2004-06-24 | 2005-06-24 | Method of modulating transporters of atp-binding cassette |
RU2009141996/04A RU2528046C2 (en) | 2004-06-24 | 2005-06-24 | Modulators of atp-binding cartridge transporters |
Country Status (1)
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RU (3) | RU2556984C2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
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RS59420B1 (en) | 2011-12-30 | 2019-11-29 | Hanmi Pharmaceutical Co Ltd | Thieno[3,2-d]pyrimidine derivatives having inhibitory activity for protein kinases |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3524858A (en) * | 1967-05-18 | 1970-08-18 | Warner Lambert Pharmaceutical | 1,4 - dihydro-1-substituted alkyl-6,7-methylenedioxy - 4 - oxoquinoline-3-carboxylic acid |
US3443940A (en) * | 1967-07-24 | 1969-05-13 | Polaroid Corp | Diffusion transfer employing ringclosure to release color-providing material for transfer |
US4110355A (en) * | 1972-12-26 | 1978-08-29 | Polaroid Corporation | Anthraquinone compounds useful in photographic processes |
GB1433774A (en) * | 1973-02-26 | 1976-04-28 | Allen & Hanburys Ltd | Heterocyclic compounds apparatus for conveying articles |
GB1433151A (en) * | 1973-04-05 | 1976-04-22 | Allen & Hanburys Ltd | Benzo-ij-quinolizines |
FR2340735A1 (en) * | 1976-02-11 | 1977-09-09 | Roussel Uclaf | NEW DERIVATIVES OF 3-QUINOLEINE CARBOXYLIC ACID, THEIR METHOD OF PREPARATION AND THEIR APPLICATION AS A MEDICINAL PRODUCT |
SU1360584A3 (en) * | 1983-08-12 | 1987-12-15 | Варнер-Ламберт Компани (Фирма) | Method of producing naphthyrydine quinoline- or benzoxazine carbolic acids or their pharmaceutically acceptable salts of acid addition |
US4786644A (en) * | 1987-11-27 | 1988-11-22 | Hoechst-Roussel Pharmaceuticals Inc. | 1-aryl-3-quinolinecarboxamide |
DE3903799A1 (en) * | 1989-02-09 | 1990-08-16 | Bayer Ag | N-ARYL NITROGEN HETEROCYCLES |
DE69628019T2 (en) * | 1995-08-02 | 2004-01-22 | Darwin Discovery Ltd., Slough | CHINOLONES AND THEIR THERAPEUTIC USE |
ATE312820T1 (en) * | 1999-10-28 | 2005-12-15 | Trine Pharmaceuticals Inc | PUMP INHIBITORS FOR DRUG RELEASE |
CN1191252C (en) * | 2003-08-11 | 2005-03-02 | 中国药科大学 | 3-position substituted quinolone derivativers and its use in pharmacy |
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2005
- 2005-06-24 RU RU2009142030/04A patent/RU2556984C2/en active
- 2005-06-24 RU RU2009142031/04A patent/RU2525115C2/en active
- 2005-06-24 RU RU2009141996/04A patent/RU2528046C2/en active
Also Published As
Publication number | Publication date |
---|---|
RU2525115C2 (en) | 2014-08-10 |
RU2556984C2 (en) | 2015-07-20 |
RU2009142031A (en) | 2011-05-20 |
RU2009141996A (en) | 2011-05-20 |
RU2528046C2 (en) | 2014-09-10 |
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