RU2008145712A - Вакцина против папилломовирусной инфекции на основе вируса папиломы человека впч-16 - Google Patents
Вакцина против папилломовирусной инфекции на основе вируса папиломы человека впч-16 Download PDFInfo
- Publication number
- RU2008145712A RU2008145712A RU2008145712/13A RU2008145712A RU2008145712A RU 2008145712 A RU2008145712 A RU 2008145712A RU 2008145712/13 A RU2008145712/13 A RU 2008145712/13A RU 2008145712 A RU2008145712 A RU 2008145712A RU 2008145712 A RU2008145712 A RU 2008145712A
- Authority
- RU
- Russia
- Prior art keywords
- hpv
- polypeptide
- polypeptides
- use according
- early
- Prior art date
Links
- 241000341655 Human papillomavirus type 16 Species 0.000 title claims abstract 35
- 241000701806 Human papillomavirus Species 0.000 title claims abstract 8
- 208000015181 infectious disease Diseases 0.000 title claims abstract 5
- 229960005486 vaccine Drugs 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 42
- 102000004196 processed proteins & peptides Human genes 0.000 claims abstract 41
- 229920001184 polypeptide Polymers 0.000 claims abstract 40
- 150000007523 nucleic acids Chemical class 0.000 claims abstract 14
- 108020004707 nucleic acids Proteins 0.000 claims abstract 13
- 102000039446 nucleic acids Human genes 0.000 claims abstract 13
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 12
- 101000954493 Human papillomavirus type 16 Protein E6 Proteins 0.000 claims abstract 7
- 231100001222 nononcogenic Toxicity 0.000 claims abstract 5
- 230000001575 pathological effect Effects 0.000 claims abstract 5
- 241001631646 Papillomaviridae Species 0.000 claims abstract 2
- 239000003814 drug Substances 0.000 claims abstract 2
- 230000028993 immune response Effects 0.000 claims abstract 2
- 230000001939 inductive effect Effects 0.000 claims abstract 2
- 238000004519 manufacturing process Methods 0.000 claims abstract 2
- 229940126601 medicinal product Drugs 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims abstract 2
- 239000013598 vector Substances 0.000 claims 8
- 101000767631 Human papillomavirus type 16 Protein E7 Proteins 0.000 claims 5
- 101100232904 Homo sapiens IL2 gene Proteins 0.000 claims 4
- 241000700618 Vaccinia virus Species 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 3
- 102000004127 Cytokines Human genes 0.000 claims 3
- 206010008263 Cervical dysplasia Diseases 0.000 claims 2
- 101100321817 Human parvovirus B19 (strain HV) 7.5K gene Proteins 0.000 claims 2
- 208000007951 cervical intraepithelial neoplasia Diseases 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 230000003248 secreting effect Effects 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 206010061424 Anal cancer Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 101710160621 Fusion glycoprotein F0 Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 241000712079 Measles morbillivirus Species 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000037581 Persistent Infection Diseases 0.000 claims 1
- 208000006994 Precancerous Conditions Diseases 0.000 claims 1
- 101900083372 Rabies virus Glycoprotein Proteins 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 201000007538 anal carcinoma Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 239000013603 viral vector Substances 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/025—Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/24011—Poxviridae
- C12N2710/24111—Orthopoxvirus, e.g. vaccinia virus, variola
- C12N2710/24141—Use of virus, viral particle or viral elements as a vector
- C12N2710/24143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Biotechnology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06360014.2 | 2006-04-21 | ||
| EP06360014 | 2006-04-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008145712A true RU2008145712A (ru) | 2010-05-27 |
Family
ID=38362856
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008145712/13A RU2008145712A (ru) | 2006-04-21 | 2007-04-17 | Вакцина против папилломовирусной инфекции на основе вируса папиломы человека впч-16 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20100061957A1 (https=) |
| EP (1) | EP2013230A2 (https=) |
| JP (1) | JP2009534332A (https=) |
| KR (1) | KR20090005011A (https=) |
| CN (1) | CN101426811A (https=) |
| AU (1) | AU2007241406A1 (https=) |
| BR (1) | BRPI0710238A2 (https=) |
| CA (1) | CA2649392A1 (https=) |
| IL (1) | IL193661A0 (https=) |
| MX (1) | MX2008013488A (https=) |
| NO (1) | NO20084857L (https=) |
| RU (1) | RU2008145712A (https=) |
| WO (1) | WO2007121895A2 (https=) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8877206B2 (en) | 2007-03-22 | 2014-11-04 | Pds Biotechnology Corporation | Stimulation of an immune response by cationic lipids |
| US8926961B2 (en) * | 2007-10-03 | 2015-01-06 | Board Of Trustees Of The University Of Arkansas | HPV E6 protein T cell epitopes and uses thereof |
| EP2276495B1 (en) | 2008-04-17 | 2018-11-21 | PDS Biotechnology Corporation | Stimulation of an immune response by enantiomers of cationic lipids |
| EP2239330A1 (en) * | 2009-04-07 | 2010-10-13 | Institut Pasteur | Neuron generation, regeneration and protection |
| AU2011279365A1 (en) * | 2010-07-15 | 2013-03-07 | British Columbia Cancer Agency Branch | Human papillomavirus E7 antigen compositions and uses thereof |
| CN102343103B (zh) * | 2011-07-26 | 2016-04-27 | 马丁 | 人乳头状瘤病毒16型三肽疫苗的筛选和验证及持续表达hpv16 e5, e6, e7的肿瘤动物模型的构建 |
| EP2601968A1 (en) * | 2011-12-06 | 2013-06-12 | Deutsches Krebsforschungszentrum | HPV derived polynucleic acids for therapy |
| CA2876656C (en) | 2012-06-15 | 2023-09-26 | Pds Biotechnology Corporation | Cationic lipid vaccine compositions and methods of use |
| CN113144188A (zh) | 2012-09-21 | 2021-07-23 | Pds生物科技公司 | 改进的疫苗组合物和使用方法 |
| US9000736B2 (en) | 2013-05-03 | 2015-04-07 | Cooper Technologies Company | Power factor correction algorithm for arbitrary input waveform |
| US9190901B2 (en) | 2013-05-03 | 2015-11-17 | Cooper Technologies Company | Bridgeless boost power factor correction circuit for constant current input |
| US9214855B2 (en) | 2013-05-03 | 2015-12-15 | Cooper Technologies Company | Active power factor correction circuit for a constant current power converter |
| US9548794B2 (en) | 2013-05-03 | 2017-01-17 | Cooper Technologies Company | Power factor correction for constant current input with power line communication |
| CA3005251A1 (en) | 2015-11-13 | 2017-05-18 | Pds Biotechnology Corporation | Lipids as synthetic vectors to enhance antigen processing and presentation ex-vivo in dendritic cell therapy |
| JP2019517522A (ja) * | 2016-06-03 | 2019-06-24 | エトゥビクス コーポレーション | ヒトパピローマウイルス（ｈｐｖ）関連疾患の処置のための組成物及び方法 |
| EP3522908A4 (en) | 2016-10-05 | 2020-06-24 | PDS Biotechnology Corporation | INNOVATIVE HPV16 NON-HLA-RESTRICTED T-CELL VACCINES, COMPOSITIONS AND METHODS FOR USE THEREOF |
| WO2019113200A1 (en) | 2017-12-05 | 2019-06-13 | Pds Biotechnology Corporation | Methods and compositions comprising cationic lipids for stimulating type 1 interferon genes |
| WO2020117715A1 (en) | 2018-12-03 | 2020-06-11 | Board Of Regents, The University Of Texas System | Oligo-benzamide analogs and their use in cancer treatment |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN015794A0 (en) * | 1994-12-20 | 1995-01-19 | Csl Limited | Variants of human papilloma virus antigens |
| FR2766091A1 (fr) * | 1997-07-18 | 1999-01-22 | Transgene Sa | Composition antitumorale a base de polypeptide immunogene de localisation cellulaire modifiee |
| WO2002077012A2 (en) * | 2001-03-23 | 2002-10-03 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Human papilloma virus immunoreative peptides |
| AU2003284239B2 (en) * | 2002-10-21 | 2008-08-21 | Eisai Inc. | Compositions and methods for treating human papillomavirus-mediated disease |
-
2007
- 2007-04-17 EP EP07724305A patent/EP2013230A2/en not_active Withdrawn
- 2007-04-17 CA CA002649392A patent/CA2649392A1/en not_active Abandoned
- 2007-04-17 KR KR1020087025575A patent/KR20090005011A/ko not_active Ceased
- 2007-04-17 MX MX2008013488A patent/MX2008013488A/es not_active Application Discontinuation
- 2007-04-17 WO PCT/EP2007/003368 patent/WO2007121895A2/en not_active Ceased
- 2007-04-17 BR BRPI0710238-0A patent/BRPI0710238A2/pt not_active IP Right Cessation
- 2007-04-17 US US12/297,977 patent/US20100061957A1/en not_active Abandoned
- 2007-04-17 CN CNA2007800143963A patent/CN101426811A/zh active Pending
- 2007-04-17 JP JP2009505767A patent/JP2009534332A/ja not_active Withdrawn
- 2007-04-17 RU RU2008145712/13A patent/RU2008145712A/ru unknown
- 2007-04-17 AU AU2007241406A patent/AU2007241406A1/en not_active Abandoned
-
2008
- 2008-08-25 IL IL193661A patent/IL193661A0/en unknown
- 2008-11-18 NO NO20084857A patent/NO20084857L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| KR20090005011A (ko) | 2009-01-12 |
| CA2649392A1 (en) | 2007-11-01 |
| WO2007121895A3 (en) | 2008-03-20 |
| JP2009534332A (ja) | 2009-09-24 |
| IL193661A0 (en) | 2011-08-01 |
| AU2007241406A1 (en) | 2007-11-01 |
| NO20084857L (no) | 2008-11-18 |
| US20100061957A1 (en) | 2010-03-11 |
| EP2013230A2 (en) | 2009-01-14 |
| WO2007121895A2 (en) | 2007-11-01 |
| BRPI0710238A2 (pt) | 2011-08-09 |
| CN101426811A (zh) | 2009-05-06 |
| MX2008013488A (es) | 2008-10-30 |
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