RU2008112923A - METHOD FOR PRODUCING ACETAMIDINE HYDROCHLORIDE - Google Patents

METHOD FOR PRODUCING ACETAMIDINE HYDROCHLORIDE Download PDF

Info

Publication number
RU2008112923A
RU2008112923A RU2008112923/04A RU2008112923A RU2008112923A RU 2008112923 A RU2008112923 A RU 2008112923A RU 2008112923/04 A RU2008112923/04 A RU 2008112923/04A RU 2008112923 A RU2008112923 A RU 2008112923A RU 2008112923 A RU2008112923 A RU 2008112923A
Authority
RU
Russia
Prior art keywords
acetamidine hydrochloride
carried out
iminoether
ammonia
producing
Prior art date
Application number
RU2008112923/04A
Other languages
Russian (ru)
Other versions
RU2394811C2 (en
Inventor
Виктор Александрович Кашаев (RU)
Виктор Александрович Кашаев
Алла Павловна Баврина (RU)
Алла Павловна Баврина
Елена Григорьевна Кожуховская (RU)
Елена Григорьевна Кожуховская
Сергей Иванович Валешний (RU)
Сергей Иванович Валешний
Владимир Петрович Ильин (RU)
Владимир Петрович Ильин
Original Assignee
Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл" (RU)
Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл"
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл" (RU), Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл" filed Critical Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт "Кристалл" (RU)
Priority to RU2008112923/04A priority Critical patent/RU2394811C2/en
Publication of RU2008112923A publication Critical patent/RU2008112923A/en
Application granted granted Critical
Publication of RU2394811C2 publication Critical patent/RU2394811C2/en

Links

Landscapes

  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Способ получения ацетамидина гидрохлорида конденсацией ацетонитрила с низшими спиртами в присутствии хлористого водорода с последующей обработкой полученного иминоэфира аммиаком, отличающийся тем, что в качестве растворителя реакции используют дихлорэтан, а выделение ацетамидина гидрохлорида проводят с зацикловкой маточника. ! 2. Способ по п.1, отличающийся тем, что получение ацетамидина гидрохлорида проводят дозировкой суспензии иминоэфира в насыщенный аммиаком метиловый спирт.1. The method of producing acetamidine hydrochloride by condensation of acetonitrile with lower alcohols in the presence of hydrogen chloride, followed by treatment of the resulting iminoether with ammonia, characterized in that dichloroethane is used as a reaction solvent, and the isolation of acetamidine hydrochloride is carried out with cycling of the mother liquor. ! 2. The method according to claim 1, characterized in that the production of acetamidine hydrochloride is carried out by dosing a suspension of iminoether in ammonia saturated methyl alcohol.

Claims (2)

1. Способ получения ацетамидина гидрохлорида конденсацией ацетонитрила с низшими спиртами в присутствии хлористого водорода с последующей обработкой полученного иминоэфира аммиаком, отличающийся тем, что в качестве растворителя реакции используют дихлорэтан, а выделение ацетамидина гидрохлорида проводят с зацикловкой маточника.1. The method of producing acetamidine hydrochloride by condensation of acetonitrile with lower alcohols in the presence of hydrogen chloride, followed by treatment of the resulting iminoether with ammonia, characterized in that dichloroethane is used as a reaction solvent, and the isolation of acetamidine hydrochloride is carried out with cycling of the mother liquor. 2. Способ по п.1, отличающийся тем, что получение ацетамидина гидрохлорида проводят дозировкой суспензии иминоэфира в насыщенный аммиаком метиловый спирт. 2. The method according to claim 1, characterized in that the production of acetamidine hydrochloride is carried out by dosing a suspension of iminoether in ammonia saturated methyl alcohol.
RU2008112923/04A 2008-04-03 2008-04-03 Method of producing acetamidine hydrochloride RU2394811C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2008112923/04A RU2394811C2 (en) 2008-04-03 2008-04-03 Method of producing acetamidine hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2008112923/04A RU2394811C2 (en) 2008-04-03 2008-04-03 Method of producing acetamidine hydrochloride

Publications (2)

Publication Number Publication Date
RU2008112923A true RU2008112923A (en) 2009-10-10
RU2394811C2 RU2394811C2 (en) 2010-07-20

Family

ID=41260456

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008112923/04A RU2394811C2 (en) 2008-04-03 2008-04-03 Method of producing acetamidine hydrochloride

Country Status (1)

Country Link
RU (1) RU2394811C2 (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110038459A (en) * 2019-05-22 2019-07-23 蚌埠学院 A kind of device and preparation method thereof preparing hydrogen chloride methanol solution
CN111269145A (en) * 2020-03-11 2020-06-12 唐山威格化学工业有限公司 Preparation method of acetamidine hydrochloride
CN112679387A (en) * 2020-12-31 2021-04-20 江苏兄弟维生素有限公司 Preparation method and application of acetamidine hydrochloride
CN115850211A (en) * 2022-11-29 2023-03-28 江苏兄弟维生素有限公司 Process method for synthesizing and coproducing acetamidine hydrochloride from alpha-chloro-alpha-acetyl-gamma-butyrolactone and application thereof

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102924331A (en) * 2012-11-02 2013-02-13 南通天泽化工有限公司 Preparation method for salifying trimethyl orthoacetate

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110038459A (en) * 2019-05-22 2019-07-23 蚌埠学院 A kind of device and preparation method thereof preparing hydrogen chloride methanol solution
CN110038459B (en) * 2019-05-22 2024-01-19 蚌埠学院 Device for preparing hydrogen chloride methanol solution and preparation method thereof
CN111269145A (en) * 2020-03-11 2020-06-12 唐山威格化学工业有限公司 Preparation method of acetamidine hydrochloride
CN112679387A (en) * 2020-12-31 2021-04-20 江苏兄弟维生素有限公司 Preparation method and application of acetamidine hydrochloride
CN112679387B (en) * 2020-12-31 2023-01-03 江苏兄弟维生素有限公司 Preparation method and application of acetamidine hydrochloride
CN115850211A (en) * 2022-11-29 2023-03-28 江苏兄弟维生素有限公司 Process method for synthesizing and coproducing acetamidine hydrochloride from alpha-chloro-alpha-acetyl-gamma-butyrolactone and application thereof

Also Published As

Publication number Publication date
RU2394811C2 (en) 2010-07-20

Similar Documents

Publication Publication Date Title
CO2017004034A2 (en) Means and methods for producing amide compounds with less acrylic acid
EA201171461A1 (en) OBTAINING NALMEPHENE OF HYDROCHLORIDE FROM NALTREX
BR112012023838A2 (en) catalytic composition and process for producing acrylonitrile, acetonitrile and hydrocyanic acid
CO6290676A2 (en) RECOVERY OF HIGHER ALCOHOLS FROM DILUATED WATER SOLUTIONS
EA201890472A2 (en) METHOD OF MANUFACTURING UREA FROM AMMONIA AND CARBON DIOXIDE
RU2008112923A (en) METHOD FOR PRODUCING ACETAMIDINE HYDROCHLORIDE
AR074845A1 (en) SYNTHESIS PROCEDURE OF IVABRADINE AND ITS ADDITION SALTS TO A PHARMACEUTICALLY ACCEPTABLE ACID
CO6491074A2 (en) RECOVERY OF HIGHER ALCOHOLS FROM DILUATED WATER SOLUTIONS
EA201071120A1 (en) METHOD OF OBTAINING HETEROARILBENZE DERIVATIVES OF SULFAMATES AND CRYSTALLINE FORM N - ((2S) -6-CHLOR-2,3-DIGYDRO-L, 4-BENZODIOXIN-2-IL) METHYL SULFAMIDE
AP2010005262A0 (en) Improved method for the production of hydrocyanic acid by catalytic dehydration of gaseous formamide
AP2010005263A0 (en) Improved method for the production of hydrocyanic acid by means of catalytic dehydration of gaseous formamide
EA201270284A1 (en) APPARATUS FOR THE DECOMPOSITION OF NON-PROTEINING AMMONIUM CARBAMATE IN UREA URINE SOLUTIONS IN THE URINE SYNTHESIS METHOD
RU2012140308A (en) STABLE WATER ACRYLAMIDE SOLUTION
RU2013128041A (en) METHOD FOR PRODUCING GRAPHENE
BR112015023343A2 (en) method of preparing sovaprevir, method of preparing a compound of formula (c), method of preparing compound f-2, compound, process, method of preparing a pure amorphous form of sovaprevir, and crystalline form of sovaprevir
BR112015031722A2 (en) method of preparation of 4-benzyl-1-phenethylpiperazine-2,6-dione, and intermediate and method of preparation thereof
MX2015011721A (en) A process for preparation of (2s, 5r)-7-oxo-6-sulphooxy-2-[((3r)- pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2 .1]octane.
MX345137B (en) Process for the treatment of liquefied hydrocarbons using 3-(amino) propane-1,2-diol compounds.
MD20140048A2 (en) Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
AR078904A1 (en) ENANTIOMER 4R, 5S OF 2- (5-METHYL-2-OXO-4-PHENYL-PIRROLIDIN-1-IL) -ATAMETER WITH NOOTROPIC ACTIVITY
DK1646582T3 (en) Process for Preparing Aluminum Trihydrates with High Pore Volume
RU2006126924A (en) METHOD FOR PRODUCING 2,4-DIALCOXY-6-TRINITROMETHYL-1,3,5-TRIAZINES
TH91441B (en) Method for the production of secandary butanol
RU2009132317A (en) METHOD FOR PRODUCING A RADIOPHARMATIC PRODUCT WITH PALLADIUM-103
RU2010149405A (en) METHOD FOR SYNTHESIS 2,4,6,8,10,12-HEXABENZYL-2,4,6,8,10,12-HEXAAZATETRACYCLO [5,5,0,03,11,05,9] DODECAN

Legal Events

Date Code Title Description
PC43 Official registration of the transfer of the exclusive right without contract for inventions

Effective date: 20130215

MM4A The patent is invalid due to non-payment of fees

Effective date: 20140404