RU2008112923A - METHOD FOR PRODUCING ACETAMIDINE HYDROCHLORIDE - Google Patents
METHOD FOR PRODUCING ACETAMIDINE HYDROCHLORIDE Download PDFInfo
- Publication number
- RU2008112923A RU2008112923A RU2008112923/04A RU2008112923A RU2008112923A RU 2008112923 A RU2008112923 A RU 2008112923A RU 2008112923/04 A RU2008112923/04 A RU 2008112923/04A RU 2008112923 A RU2008112923 A RU 2008112923A RU 2008112923 A RU2008112923 A RU 2008112923A
- Authority
- RU
- Russia
- Prior art keywords
- acetamidine hydrochloride
- carried out
- iminoether
- ammonia
- producing
- Prior art date
Links
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1. Способ получения ацетамидина гидрохлорида конденсацией ацетонитрила с низшими спиртами в присутствии хлористого водорода с последующей обработкой полученного иминоэфира аммиаком, отличающийся тем, что в качестве растворителя реакции используют дихлорэтан, а выделение ацетамидина гидрохлорида проводят с зацикловкой маточника. ! 2. Способ по п.1, отличающийся тем, что получение ацетамидина гидрохлорида проводят дозировкой суспензии иминоэфира в насыщенный аммиаком метиловый спирт.1. The method of producing acetamidine hydrochloride by condensation of acetonitrile with lower alcohols in the presence of hydrogen chloride, followed by treatment of the resulting iminoether with ammonia, characterized in that dichloroethane is used as a reaction solvent, and the isolation of acetamidine hydrochloride is carried out with cycling of the mother liquor. ! 2. The method according to claim 1, characterized in that the production of acetamidine hydrochloride is carried out by dosing a suspension of iminoether in ammonia saturated methyl alcohol.
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008112923/04A RU2394811C2 (en) | 2008-04-03 | 2008-04-03 | Method of producing acetamidine hydrochloride |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2008112923/04A RU2394811C2 (en) | 2008-04-03 | 2008-04-03 | Method of producing acetamidine hydrochloride |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2008112923A true RU2008112923A (en) | 2009-10-10 |
RU2394811C2 RU2394811C2 (en) | 2010-07-20 |
Family
ID=41260456
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2008112923/04A RU2394811C2 (en) | 2008-04-03 | 2008-04-03 | Method of producing acetamidine hydrochloride |
Country Status (1)
Country | Link |
---|---|
RU (1) | RU2394811C2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110038459A (en) * | 2019-05-22 | 2019-07-23 | 蚌埠学院 | A kind of device and preparation method thereof preparing hydrogen chloride methanol solution |
CN111269145A (en) * | 2020-03-11 | 2020-06-12 | 唐山威格化学工业有限公司 | Preparation method of acetamidine hydrochloride |
CN112679387A (en) * | 2020-12-31 | 2021-04-20 | 江苏兄弟维生素有限公司 | Preparation method and application of acetamidine hydrochloride |
CN115850211A (en) * | 2022-11-29 | 2023-03-28 | 江苏兄弟维生素有限公司 | Process method for synthesizing and coproducing acetamidine hydrochloride from alpha-chloro-alpha-acetyl-gamma-butyrolactone and application thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102924331A (en) * | 2012-11-02 | 2013-02-13 | 南通天泽化工有限公司 | Preparation method for salifying trimethyl orthoacetate |
-
2008
- 2008-04-03 RU RU2008112923/04A patent/RU2394811C2/en not_active IP Right Cessation
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110038459A (en) * | 2019-05-22 | 2019-07-23 | 蚌埠学院 | A kind of device and preparation method thereof preparing hydrogen chloride methanol solution |
CN110038459B (en) * | 2019-05-22 | 2024-01-19 | 蚌埠学院 | Device for preparing hydrogen chloride methanol solution and preparation method thereof |
CN111269145A (en) * | 2020-03-11 | 2020-06-12 | 唐山威格化学工业有限公司 | Preparation method of acetamidine hydrochloride |
CN112679387A (en) * | 2020-12-31 | 2021-04-20 | 江苏兄弟维生素有限公司 | Preparation method and application of acetamidine hydrochloride |
CN112679387B (en) * | 2020-12-31 | 2023-01-03 | 江苏兄弟维生素有限公司 | Preparation method and application of acetamidine hydrochloride |
CN115850211A (en) * | 2022-11-29 | 2023-03-28 | 江苏兄弟维生素有限公司 | Process method for synthesizing and coproducing acetamidine hydrochloride from alpha-chloro-alpha-acetyl-gamma-butyrolactone and application thereof |
Also Published As
Publication number | Publication date |
---|---|
RU2394811C2 (en) | 2010-07-20 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CO2017004034A2 (en) | Means and methods for producing amide compounds with less acrylic acid | |
EA201171461A1 (en) | OBTAINING NALMEPHENE OF HYDROCHLORIDE FROM NALTREX | |
BR112012023838A2 (en) | catalytic composition and process for producing acrylonitrile, acetonitrile and hydrocyanic acid | |
CO6290676A2 (en) | RECOVERY OF HIGHER ALCOHOLS FROM DILUATED WATER SOLUTIONS | |
EA201890472A2 (en) | METHOD OF MANUFACTURING UREA FROM AMMONIA AND CARBON DIOXIDE | |
RU2008112923A (en) | METHOD FOR PRODUCING ACETAMIDINE HYDROCHLORIDE | |
AR074845A1 (en) | SYNTHESIS PROCEDURE OF IVABRADINE AND ITS ADDITION SALTS TO A PHARMACEUTICALLY ACCEPTABLE ACID | |
CO6491074A2 (en) | RECOVERY OF HIGHER ALCOHOLS FROM DILUATED WATER SOLUTIONS | |
EA201071120A1 (en) | METHOD OF OBTAINING HETEROARILBENZE DERIVATIVES OF SULFAMATES AND CRYSTALLINE FORM N - ((2S) -6-CHLOR-2,3-DIGYDRO-L, 4-BENZODIOXIN-2-IL) METHYL SULFAMIDE | |
AP2010005262A0 (en) | Improved method for the production of hydrocyanic acid by catalytic dehydration of gaseous formamide | |
AP2010005263A0 (en) | Improved method for the production of hydrocyanic acid by means of catalytic dehydration of gaseous formamide | |
EA201270284A1 (en) | APPARATUS FOR THE DECOMPOSITION OF NON-PROTEINING AMMONIUM CARBAMATE IN UREA URINE SOLUTIONS IN THE URINE SYNTHESIS METHOD | |
RU2012140308A (en) | STABLE WATER ACRYLAMIDE SOLUTION | |
RU2013128041A (en) | METHOD FOR PRODUCING GRAPHENE | |
BR112015023343A2 (en) | method of preparing sovaprevir, method of preparing a compound of formula (c), method of preparing compound f-2, compound, process, method of preparing a pure amorphous form of sovaprevir, and crystalline form of sovaprevir | |
BR112015031722A2 (en) | method of preparation of 4-benzyl-1-phenethylpiperazine-2,6-dione, and intermediate and method of preparation thereof | |
MX2015011721A (en) | A process for preparation of (2s, 5r)-7-oxo-6-sulphooxy-2-[((3r)- pyrrolidine-3-carbonyl)-hydrazino carbonyl]-1,6-diaza-bicyclo[3.2 .1]octane. | |
MX345137B (en) | Process for the treatment of liquefied hydrocarbons using 3-(amino) propane-1,2-diol compounds. | |
MD20140048A2 (en) | Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid | |
AR078904A1 (en) | ENANTIOMER 4R, 5S OF 2- (5-METHYL-2-OXO-4-PHENYL-PIRROLIDIN-1-IL) -ATAMETER WITH NOOTROPIC ACTIVITY | |
DK1646582T3 (en) | Process for Preparing Aluminum Trihydrates with High Pore Volume | |
RU2006126924A (en) | METHOD FOR PRODUCING 2,4-DIALCOXY-6-TRINITROMETHYL-1,3,5-TRIAZINES | |
TH91441B (en) | Method for the production of secandary butanol | |
RU2009132317A (en) | METHOD FOR PRODUCING A RADIOPHARMATIC PRODUCT WITH PALLADIUM-103 | |
RU2010149405A (en) | METHOD FOR SYNTHESIS 2,4,6,8,10,12-HEXABENZYL-2,4,6,8,10,12-HEXAAZATETRACYCLO [5,5,0,03,11,05,9] DODECAN |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC43 | Official registration of the transfer of the exclusive right without contract for inventions |
Effective date: 20130215 |
|
MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20140404 |