RU2008014C1 - Process for preparation of biologically active agent from pot marigold (calendula officinalis) raw material for cosmetics - Google Patents

Abstract

FIELD: pharmaceutic-chemical industry. SUBSTANCE: marigold top raw material is extracted in a 24-26 % alcoholic solution, raw-extractant ratio of 1: (10-12), at 50-60 C for 1.5-2 hrs. The resulting supernatant is decanted, and the residue is extracted and decanted again. The combined extractive layers are filtered, the filtrate is evaporated and dried to give the end product. The evaporation of filtrate is carried outto solid residue content of 115-20 % . The end product is dried at air temperature 160-140 C at inlet and 80-75 C at outlet and air mixture flow rate being 2-2.5 l/h. EFFECT: increased efficiency. 2 cl

Description

 The invention relates to the pharmaceutical industry, and in particular to methods for producing dry plant extracts that can be used as biologically active additives in cosmetic products.

 The medicinal calendula plant (Calendula officinalis L) is cultivated in the USSR as a wild-growing and medicinal plant. Calendula contains various biologically active substances. So flower baskets are rich in carotenoids; in marigold inflorescences there are resins, mucus, nitrogen-containing mucus, acids - malic and salicylic; the roots contain inulin, saponin in the aboveground organs, and essential oil in the seeds. A variety of biologically active substances contributes to the widespread use of calendula in medical practice in the treatment of various diseases, as well as in cosmetics as a biologically active additive to cosmetic products.

 In cosmetic products, calendula oil extract is used, obtained by extracting flowers with oil at a raw material-extractant ratio of 1: 4.

 The closest in technical essence and selected as a prototype is a method for producing alcohol-glycerin extract of calendula flowers by treating crushed raw materials with an extractant (TU 6-15-06 322-87 "Plant extracts stabilized").

 The proposed method allows to obtain a biologically active additive from calendula in the form of a dry bulk product, as the most rational type of extract.

The essence of the invention lies in the fact that the aerial part of calendula is subjected to extraction and it is carried out 24-26 ^about alcohol with an extractant-raw material ratio of 10-12: 1 at 50-60 ^about C for 1.5-2 hours

At the end of the process, the extract is drained, and the remaining raw materials are re-extracted under the same conditions. The extracts are combined, filtered, concentrated and dried. The desired product is concentrated to a concentration of 15-20% dry matter, and its drying is carried out at an inlet air temperature ^of 160-140 C and 80-75 ^{° C} outlet at a feed rate mixture 2-2.5 l / h.

 A method of obtaining a dietary supplement from calendula in dry form is illustrated by the following specific examples.

PRI me R 1. 1 kg of dry aerial parts (herbs) marigold is crushed to a particle size of 2-3 mm, pour 10 l of 24% ethyl alcohol and the extraction is carried out with constant stirring for 1 h at 50 ^about C. The extract at the end of the extraction process in an amount of 8 l is drained, and the remaining raw materials are re-extracted under the same conditions, feeding the extract in a volume equal to the drained. The extracts were combined, filtered and concentrated under vacuum (P = _Ost 5-10 mm Hg. V.) In the evaporator circulation apparatus or a rotary-film evaporator at a temperature of 40-50 ^{° C} to a concentration of 15-20% dry matter. The concentrate was dried in a spray drier at an inlet temperature of 160-140 ^{° C,} outlet 80-70 ^{° C} at a rate of feeding the mixture of 2-2.5 l / h. The resulting dry extract is packaged.

PRI me R 2. 1 kg of dry aerial part (grass) of calendula (Calendula officinalis L), crushed to a particle size of 2-3 mm, pour 12 and 26% ethanol and extraction is carried out with constant stirring for 1 5 hours at 60 ^C. the resulting extract in an amount of 10 l was discarded and the raw material is re-extracted under the same conditions, giving the extract in an amount equal fusion.

 Next, the process is conducted as in example 1.

 The yield of dry extract of calendula is 30-35% by weight of the feedstock.

 The technical result from the use of the proposed method consists in the intensification of the process, as well as obtaining a dry bulk product.

 Obtained by the proposed method, dry extract of calendula is an amorphous powder from yellow to brown in color with a specific odor. Hygroscopic, crumple.

 The content of active substances is determined by the sum of flavonoids, standardization is carried out according to quartzetin or luteolin-7-glucoside.

 Calendula dry extract can be used as a biologically active supplement with anti-inflammatory effect in various types of cosmetic products.

 (56) TU 6-15-06 322-87 Stabilized plant extracts.

Claims (3)

1. METHOD FOR PRODUCING A BIOLOGICALLY ACTIVE ADDITIVE FROM CALENDULA OFFICINALIS 7 FOR COSMETIC PRODUCTS by extraction with alcohol and subsequent isolation of the target product, characterized in that the aboveground part of the plant is used as raw material, which is extracted with 24 to 26 ^o- ratio extractant feedstock 1: 10-12 at 50-60 ^{° C.} for 1.5-2 hours, then the extract is drained and the feedstock is re-extracted under the same conditions, then the extracts are combined, filtered, concentrated and dried.  2. The method according to p. 1, characterized in that the target product is concentrated to a dry matter concentration of 15-20%. 3. The method according to p. 1, characterized in that the drying of the target product is carried out at an air temperature at the inlet of 160 - 140 ^o With and at the outlet of 80 - 75 ^o With a flow rate of the mixture of 2 - 2.5 l / h