RU2007996C1 - Composition "kapoль" for bath therapy - Google Patents

Abstract

FIELD: bath therapy. SUBSTANCE: composition contains the following ingredients, % by weight: sodium chloride 35-45; sodium hydrogen carbonate 6-8; organic coloring agent, fluoresceine 0.015-0.02; alkylsulfonate, or soap powder, or licorice extract 2-4 and carnallite for the balance. EFFECT: high sedative, analgetic and tonic effects. 9 tbl

Description

 The invention relates to the perfumery and cosmetics industry, namely to the production of hygienic, tonic drugs used in bathtubs.

 Known tool for baths "Karina" containing sodium chloride, carbonate and sodium bicarbonate, tartaric acid, fluorescein, perfume, polyethylene glycol and dye [1]. With increased humidity, this tool becomes less stable. More stable is a product containing sodium carbonate and sodium bicarbonate, perfume, fluorescein, a dye and a filler, carbonic extract of red hot pepper [2].

 The disadvantage of these compositions is the lack of tonic, sedative and analgesic effects.

 The closest in composition and purpose is a remedy for therapeutic baths containing carnallite, kalimagnesia, calcium sulfate hemihydrate, sodium chloride [3].

 However, the known agent has a therapeutic effect in a high concentration of this composition (1% concentration).

 The aim of the invention is to develop a composition for baths with prophylactic sedative, analgesic, tonic and cleansing effects.

The goal is achieved by a new composition based on carnallite, containing sodium chloride, sodium bicarbonate, an organic dye - fluorescein and alkyl sulfonate or soap powder, or licorice root extract, in the following ratio of components, wt. %: Sodium chloride (tech.) 35-45 Sodium bicarbonate 6-8
Alkylsulfonate or
soap powder, or licorice root extract 2-4
Organic dye (fluorescein) 0.015-0.02 Carnallite Else
The compositions of the proposed means for baths are presented in table. 1. For all components of the product there are GOSTs, OSTs, and TU.

Sodium chloride (technical) TU 6-18-226-76 Sodium bicarbonate GOST 2156-76 Alkyl sulfonate OST 6-01-32-77 Soap powder TU 18-16-246-72
Extract of licorice root GOST 22840-77 Fluorescein TU 6-09-2464-82 Carnallite GOST 16109-70
The decrease in the content of the surfactant surfactant (alkyl sulfonate or soap powder, or soap shavings, or licorice root extract) in the composition of the bath product leads to a decrease in the cleansing effect, an increase can lead to a negative effect on the skin; a decrease in sodium chloride leads to reduced performance. The absence of sodium and surfactants in the composition of bicarbonate leads to a decrease in sedative and analgesic effects, i.e., to an increase in the effective concentration.

 An increase in carnallite does not lead to a biological effect.

 The tool is prepared by mixing all the components. The product is a light gray powder, quickly soluble in water. Upon dissolution, a clear solution of a pleasant yellow-green color, odorless, is formed. The lack of perfumes makes it possible to use this tool for people who are allergic to smells.

 Apply the tool by uniformly sprinkling 150 g of the mixture on the surface of thermal water in the bath, followed by stirring. Bath time 15 min.

 In the patent and scientific literature, the authors did not find a carnallite-based bath composition containing a surfactant, sodium salts, an organic dye and having a prophylactic sedative, analgesic, tonic and cleansing effect, therefore, the proposed composition is “new” and having “inventive step” "

 The components of the product are cheap natural substances and industrial wastes and are “industrially applicable”.

 PRI me R 1. The tool is prepared as follows: sodium chloride is mixed with sodium bicarbonate, alkyl sulfonate, dye and carnallite. The components are taken in the following ratio, wt. %: sodium chloride 35; sodium bicarbonate 6; alkyl sulfonate 2; fluorescein 0.025; carnallite 56.975.

 PRI me R 2. The tool is prepared analogously to example 1, with a ratio of components, wt. %: sodium chloride 45; sodium bicarbonate 8; soap shavings 3; fluorescein 0.015; carnallite 43.985.

 PRI me R 3. The tool is prepared analogously to example 1, with the ratio of components, wt. %: sodium chloride 40; sodium bicarbonate 6; licorice root extract 4; fluorescein 0.02; carnallite 59.98.

 PRI me R 4. The tool is prepared analogously to example 1, with a ratio of components, wt. %: sodium chloride 45; sodium bicarbonate 8; soap powder 4; fluorescein 0.025; carnallite 43.

The sedative effect was studied on white rats (males) of the Wistar population, the analgesic and tonic effect on white outbred mice. Animals received for 10 days the bath (concentrations of the solutions 0.3; 0.5; 0.8; 1.0%) with a temperature of 37-38 ^{° C,} duration 15 min. The control group took baths with warm tap water.

 The study of the sedative effect of the studied drug on the state of the neuromuscular apparatus (indicators of rheobase and chronaxy) was carried out using an electric stimulator. The indicators were studied in dynamics before taking baths and during 8.10 days, as well as 5 days after bath cancellation. The data obtained were processed statistically using Student's criterion and are presented in table. 2.

 The study of the tonic effect was carried out according to the technique of "repeated swimming mice". Before and after bathing, control swimming was conducted, during which the time of complete fatigue of the animals was recorded and their performance was compared. The results of the experiments are presented in table. 3.

 Analgesic activity was evaluated by the type of “hot plate”, in which the time of the conditioned defense reflex was determined. The comparison was carried out with a control group. The results were processed statistically according to Belenky M. L. (1963) (see table. 4).

 As a result of the experiments, it was found that a 0.3-1.0% concentration of the carnallite-based agent (all variants) caused a decrease in the electroexcitability of the neuromuscular apparatus. This is expressed in a significant increase in the reobase indices of laboratory animals after 10 baths in comparison with indicators before baths and control after baths. A 0.5% concentration of the agent (for all options) causes a significant increase in the time of the conditioned defense reaction in the experimental groups of animals compared with the control (Table 2).

 Baths with a 0.3% concentration have a tonic effect. The performance of animals after taking baths, depending on the variant of the product, increased by 22-30% (Table 3).

 Thus, a carnallite-based bath product in 0.3-0.5% concentrations has a sedative effect, has an analgesic (analgesic) effect, and improves performance.

 The proposed tool for baths also has a calming and analgesic effect.

Toxicological studies were conducted according to the purpose and nature of the drug in three animal species: guinea pigs, white rats and white mice. The composition was studied with the following contact routes:
- intragastric;
- upper respiratory tract;
- through the skin.

 Toxicity was studied on white rats weighing 180-200 g with a single intragastric administration followed by daily monitoring of the condition of animals and their death within 7 days.

 Studies have shown that with the introduction of a maximum dose of 5000 mg / kg, no animal deaths were found, therefore, the bath composition according to the classification of the hazard of a substance by the degree of exposure to the body belongs to class IV - low-toxic substances (GOST 12.1.007-76).

 In order to determine and assess the possibility of exposure to the product through the upper respiratory tract, studies were conducted under conditions of statistical inhalation seeds (a 2.5 mg / l sample was established). White mice weighing 20–25 g were taken as an experiment. Inhalations were carried out for a month. The animals were monitored during the experiment. Animals evenly arrived in the mass, in general condition did not differ from the control.

 At the end of the experiment, studies were made of the functional state of the liver and nervous system and a hexenal sample (see Table 5).

 The table shows that the time of falling asleep experimental animals was slightly longer than the control, but statistically this difference was unreliable; and the sleep time of the experimental animals was statistically significantly longer than in the control, which indicates the sedative effect of the bath product.

 Similar experimental results were obtained when bathing white mice in 0.2 and 0.5% solutions of the drug daily for 15 minutes for one month (see table. 5).

 The locally irritating and allergenic effect of the bath product was studied in two animal species: guinea pigs and white rats. The composition was applied to prepared for application areas in the form of a 0.2% aqueous solution without rinsing daily. During the experiment, animals were monitored, the general condition of the animals, and the presence of local effects were recorded. The condition of the skin was assessed by the point system. During the experiment, the animals evenly arrived in the mass, the local effect was estimated at 0 points.

To determine the possible skin-resorptive action under simulated conditions, experiments were carried out both on white rats-females, which were applied with a 1% solution of the composition in the form of applications, and on white mice that took baths from 0.2 and 0 for a month every day 5% aqueous solutions of bath products. During the experiments, animals were monitored, body mass indicators, and general condition were recorded. At the end of the experiment, the following studies were carried out;
- biochemical (total protein, aspartate aminotransferase, cholinesterase, cholesterol, pyroxidase);
- clinical (hemoglobin, red blood cells, white blood cells, morphoformula);
- skin lipids, skin pH;
- histological studies.

 The results of the experiments are summarized and presented in table. 6-9.

 Experienced animals, both rats and mice, did not differ from the control; they arrived uniformly in mass. The determined biochemical clinical indicators of the condition in the experimental animals did not statistically differ from the control ones. Pathological changes in the morphology of the kidneys, liver, lungs, spleen and skin were not detected.

Summarizing the above, we can draw the following conclusions:
- Carnallite-based bath product - product of hazard class IV;
- the composition does not have a locally irritating, allergenic and skin-resorptive effect;
- the product has a calming effect, causing a change in sleep of laboratory animals.

 Thus, the bath product, which is named "Karel", contains mineral and biological active components of only natural origin, has high stability.

 Baths prepared with this product have a calming effect, reduce irritability, improve sleep, relieve soreness and fatigue, have an anti-inflammatory effect, cleanse the skin of fat and protein contaminants without disturbing its functional state.

 In addition, the licorice root extract included in the composition is a surface-active substance of plant origin, which, when dissolved in water, creates a special microclimate in the bathroom that favorably affects the respiratory system.

 The proposed composition for baths has a preventive effect, it is not toxic, does not irritate the skin, does not cause allergies and allows you to take sea baths at home. (56) 1. USSR author's certificate N 727196, cl. A 61 K 7/50, 1980.

 2. USSR author's certificate N 971334, cl. A 61 K 7/50, 1982.

 3. Copyright certificate of the USSR N 980719, cl. A 61 K 7/5, 1982.

Claims (1)

containing carnallite, sodium chloride, characterized in that it additionally contains sodium bicarbonate, alkyl sulfonate, or soap powder, or licorice root extract and an organic dye - fluorescein in the following ratio, wt. %:
Technical sodium chloride 35 - 45
Sodium Bicarbonate 6 - 8
Alkyl sulfonate, or soap powder, or licorice root extract 2-7
Organic Dye (Fulorescein) 0.015 - 0.02
Carnallite rest

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