RU2007113962A - BIORASSIBLE COLLAGENIC MATRIX, METHOD FOR ITS PRODUCTION AND APPLICATION - Google Patents
BIORASSIBLE COLLAGENIC MATRIX, METHOD FOR ITS PRODUCTION AND APPLICATION Download PDFInfo
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Abstract
1. Способ получения биорассасываемой матрицы, состоящей из нативного нереконструированного коллагена I типа, включающий обработку кожи животного, очищенной от волосяных луковиц и подкожно-жировой клетчатки, водой; обработку дермы животного водно-щелочным раствором, содержащим гидроксид натрия, калий дигидрофосфат и водный или безводный тетраборно-кислый натрий, при температуре от 1 до 10°С; обработку дермы животного водным раствором сульфата натрия и гидроксида натрия; обработку дермы животного водным раствором сульфата натрия; обработку дермы животного водным раствором борной кислоты; причем обработку дермы животного на третьей, четвертой и пятой стадиях осуществляют при периодическом взбалтывании раствора и периодическом охлаждении до температуры от 1 до 10°С; и после каждой из стадий со второй по пятую осуществляют промывку дермы водой до достижения нейтрального значения рН промывных вод.2. Способ по п.1, в котором после первой стадии дополнительно выдерживают дерму животного при температуре от 1 до 10°С, предпочтительно от 3 до 5°С.3. Способ по п.1, в котором вторую стадию осуществляют в течение 5 суток при температуре 3-5°С и замене раствора, по крайней мере, 2 раза в день.4. Способ по п.1, в котором на второй стадии в течение суток непрерывное взбалтывание раствора осуществляют 12-16 ч и оставляют раствор в состоянии покоя в течение 8-12 ч.5. Способ по любому из пп.1, 3 или 4, в котором на второй стадии в первые сутки замену раствора осуществляют через каждый час в течение 12-16 ч.6. Способ по любому из пп.1, 3 или 4, в котором на второй стадии в течение вторых, третьих, четвертых и пятых суток раствор заменяют дважды в сутк1. A method of obtaining a bioabsorbable matrix consisting of native unreconstructed type I collagen, comprising treating the skin of an animal cleansed of hair follicles and subcutaneous fat with water; treating the animal’s dermis with an aqueous alkaline solution containing sodium hydroxide, potassium dihydrogen phosphate and aqueous or anhydrous tetraborate acid sodium, at a temperature of from 1 to 10 ° C; treating the animal’s dermis with an aqueous solution of sodium sulfate and sodium hydroxide; treating the animal’s dermis with an aqueous solution of sodium sulfate; treating the animal’s dermis with an aqueous solution of boric acid; moreover, the processing of the dermis of the animal in the third, fourth and fifth stages is carried out with periodic agitation of the solution and periodic cooling to a temperature of from 1 to 10 ° C; and after each of the second to fifth steps, the dermis is washed with water until a neutral pH of the wash water is reached. 2. The method according to claim 1, in which, after the first stage, the dermis of the animal is further maintained at a temperature of from 1 to 10 ° C, preferably from 3 to 5 ° C. The method according to claim 1, in which the second stage is carried out for 5 days at a temperature of 3-5 ° C and replacing the solution at least 2 times a day. The method according to claim 1, wherein in the second stage during the day, continuous agitation of the solution is carried out for 12-16 hours and the solution is left at rest for 8-12 hours. The method according to any one of claims 1, 3 or 4, wherein in the second stage, on the first day, the solution is changed every hour for 12-16 hours. 6. The method according to any one of claims 1, 3 or 4, wherein in the second stage, during the second, third, fourth and fifth days, the solution is replaced twice a day
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RU2007113962/15A RU2353397C2 (en) | 2007-04-13 | 2007-04-13 | Bioabsorbable collagen matrix, method of production and application |
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RU2007113962/15A RU2353397C2 (en) | 2007-04-13 | 2007-04-13 | Bioabsorbable collagen matrix, method of production and application |
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RU2007113962A true RU2007113962A (en) | 2008-10-27 |
RU2353397C2 RU2353397C2 (en) | 2009-04-27 |
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RU2007113962/15A RU2353397C2 (en) | 2007-04-13 | 2007-04-13 | Bioabsorbable collagen matrix, method of production and application |
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Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
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ES2720137T3 (en) * | 2011-04-28 | 2019-07-18 | Lifecell Corp | Method for the enzymatic treatment of tissue products |
RU2627844C1 (en) * | 2016-10-24 | 2017-08-14 | Общество С Ограниченной Ответственностью "Ниармедик Плюс" | Method for obtaining suspensional form of a ruled decellularized extracellular matrix |
RU2735176C1 (en) * | 2020-04-23 | 2020-10-28 | Общество С Ограниченной Ответственностью "Ниармедик Плюс" | Microstructured collagen material for producing coherent-dispersed dermal implants |
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