RU2007103332A - Способы лечения опосредуемых ccr2 заболеваний или нарушений - Google Patents
Способы лечения опосредуемых ccr2 заболеваний или нарушений Download PDFInfo
- Publication number
- RU2007103332A RU2007103332A RU2007103332/14A RU2007103332A RU2007103332A RU 2007103332 A RU2007103332 A RU 2007103332A RU 2007103332/14 A RU2007103332/14 A RU 2007103332/14A RU 2007103332 A RU2007103332 A RU 2007103332A RU 2007103332 A RU2007103332 A RU 2007103332A
- Authority
- RU
- Russia
- Prior art keywords
- ccr2
- therapeutic agent
- subject
- administering
- treating
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims 7
- 201000010099 disease Diseases 0.000 title 1
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 20
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 20
- 239000003814 drug Substances 0.000 claims 19
- 229940124597 therapeutic agent Drugs 0.000 claims 19
- 238000012360 testing method Methods 0.000 claims 9
- 208000002705 Glucose Intolerance Diseases 0.000 claims 5
- 206010018429 Glucose tolerance impaired Diseases 0.000 claims 5
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 5
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 5
- 210000000577 adipose tissue Anatomy 0.000 claims 5
- 230000037396 body weight Effects 0.000 claims 5
- 206010012601 diabetes mellitus Diseases 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000002604 chemokine receptor CCR2 antagonist Substances 0.000 claims 3
- 102000001902 CC Chemokines Human genes 0.000 claims 2
- 108010040471 CC Chemokines Proteins 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
- A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Obesity (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US59268304P | 2004-07-30 | 2004-07-30 | |
| US60/592,683 | 2004-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007103332A true RU2007103332A (ru) | 2008-08-10 |
Family
ID=35207829
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007103332/14A RU2007103332A (ru) | 2004-07-30 | 2005-07-18 | Способы лечения опосредуемых ccr2 заболеваний или нарушений |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20090196823A1 (https=) |
| EP (1) | EP1778285A2 (https=) |
| JP (1) | JP2008508253A (https=) |
| KR (1) | KR20080044360A (https=) |
| CN (1) | CN101005855A (https=) |
| AU (1) | AU2005268545A1 (https=) |
| BR (1) | BRPI0513953A (https=) |
| CA (1) | CA2575612A1 (https=) |
| IL (1) | IL180675A0 (https=) |
| MX (1) | MX2007001204A (https=) |
| NO (1) | NO20070996L (https=) |
| RU (1) | RU2007103332A (https=) |
| WO (1) | WO2006013427A2 (https=) |
| ZA (1) | ZA200700823B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7629351B2 (en) | 2006-07-28 | 2009-12-08 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-2-oxo-3-(6-(trifluoromethyl)quinazolin-4-ylamino) pyrrolidin-1-yl)cyclohexyl)acetamide and other modulators of chemokine receptor activity, crystalline forms and process |
| US7671062B2 (en) | 2006-07-28 | 2010-03-02 | Bristol-Myers Squibb Company | Modulators of chemokine receptor activity, crystalline forms and process |
| US7687508B2 (en) | 2006-07-28 | 2010-03-30 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| JP5685535B2 (ja) * | 2008-08-18 | 2015-03-18 | ファイザー インコーポレイティッド | Ｃｃｒ２に対する抗体 |
| US8383812B2 (en) | 2009-10-13 | 2013-02-26 | Bristol-Myers Squibb Company | N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-A][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide, a dual modulator of chemokine receptor activity, crystalline forms and processes |
| US9726666B2 (en) | 2011-06-13 | 2017-08-08 | Tla Targeted Immunotherapies Ab | Diagnosing and treating inflammatory diseases |
| WO2013000922A1 (en) * | 2011-06-27 | 2013-01-03 | Universite Pierre Et Marie Curie (Paris 6) | Ccr2 antagonist peptides |
| WO2022235440A1 (en) * | 2021-04-21 | 2022-11-10 | The United States Government As Represented By The Department Of Veterans Affairs | Method for treating traumatic brain injury, spinal cord injury, or stroke using small molecule inhibitors of ccr2 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6312689B1 (en) * | 1998-07-23 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Anti-CCR2 antibodies and methods of use therefor |
| FR2792837B1 (fr) * | 1999-04-29 | 2001-07-13 | Centre Nat Rech Scient | Medicaments utiles pour le traitement des troubles de la regulation de la masse adipeuse et des maladies associees aux troubles de la production de leptine |
| CA2483253A1 (en) * | 2002-04-24 | 2003-11-06 | Takeda Pharmaceutical Company Limited | Use of compounds having ccr antagonism |
| US20060183731A1 (en) * | 2003-07-15 | 2006-08-17 | Min Ge | 7 and 8 membered heterocyclic cyclopentyl benzylamide modulators of chemokine receptor activity |
| BRPI0417605B8 (pt) * | 2003-12-18 | 2021-05-25 | Incyte Corp | n-[2-((3s)-3-{[4-hidróxi-4-(5-pirimidin-2- ilpiridin-2-il)ciclohexil]amino}-pirrolidin-1-il)-2- oxoetil]-3-(trifluor-metil)benzamida, ou um sal farmaceuticamente aceitável do mesmo e composição que o compreende. |
-
2005
- 2005-07-18 CA CA002575612A patent/CA2575612A1/en not_active Abandoned
- 2005-07-18 BR BRPI0513953-8A patent/BRPI0513953A/pt not_active IP Right Cessation
- 2005-07-18 RU RU2007103332/14A patent/RU2007103332A/ru not_active Application Discontinuation
- 2005-07-18 JP JP2007523167A patent/JP2008508253A/ja not_active Withdrawn
- 2005-07-18 CN CNA2005800276608A patent/CN101005855A/zh active Pending
- 2005-07-18 WO PCT/IB2005/002162 patent/WO2006013427A2/en not_active Ceased
- 2005-07-18 KR KR1020087010937A patent/KR20080044360A/ko not_active Ceased
- 2005-07-18 EP EP05777347A patent/EP1778285A2/en not_active Withdrawn
- 2005-07-18 MX MX2007001204A patent/MX2007001204A/es unknown
- 2005-07-18 AU AU2005268545A patent/AU2005268545A1/en not_active Abandoned
- 2005-09-16 US US11/658,989 patent/US20090196823A1/en not_active Abandoned
-
2007
- 2007-01-11 IL IL180675A patent/IL180675A0/en unknown
- 2007-01-29 ZA ZA200700823A patent/ZA200700823B/xx unknown
- 2007-02-21 NO NO20070996A patent/NO20070996L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0513953A (pt) | 2008-05-20 |
| US20090196823A1 (en) | 2009-08-06 |
| WO2006013427A3 (en) | 2006-06-08 |
| IL180675A0 (en) | 2007-06-03 |
| WO2006013427A2 (en) | 2006-02-09 |
| NO20070996L (no) | 2007-04-23 |
| CA2575612A1 (en) | 2006-02-09 |
| ZA200700823B (en) | 2008-10-29 |
| AU2005268545A1 (en) | 2006-02-09 |
| EP1778285A2 (en) | 2007-05-02 |
| MX2007001204A (es) | 2007-03-23 |
| CN101005855A (zh) | 2007-07-25 |
| JP2008508253A (ja) | 2008-03-21 |
| KR20080044360A (ko) | 2008-05-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20090317 |