RU2006143659A - Применение ребоксетина для лечения боли - Google Patents
Применение ребоксетина для лечения боли Download PDFInfo
- Publication number
- RU2006143659A RU2006143659A RU2006143659/152006143659/15A RU2006143659A RU2006143659A RU 2006143659 A RU2006143659 A RU 2006143659A RU 2006143659 A RU2006143659 A RU 2006143659A RU 2006143659 A RU2006143659 A RU 2006143659A
- Authority
- RU
- Russia
- Prior art keywords
- pain
- reboxetine
- pharmaceutically acceptable
- acceptable salt
- use according
- Prior art date
Links
- 208000002193 Pain Diseases 0.000 title claims 17
- 150000003839 salts Chemical class 0.000 claims 7
- CBQGYUDMJHNJBX-RTBURBONSA-N reboxetine Chemical compound CCOC1=CC=CC=C1O[C@H](C=1C=CC=CC=1)[C@@H]1OCCNC1 CBQGYUDMJHNJBX-RTBURBONSA-N 0.000 claims 6
- 208000004296 neuralgia Diseases 0.000 claims 5
- 208000021722 neuropathic pain Diseases 0.000 claims 5
- 229960003770 reboxetine Drugs 0.000 claims 4
- CBQGYUDMJHNJBX-OALUTQOASA-N (2S)-2-[(S)-(2-ethoxyphenoxy)-phenylmethyl]morpholine Chemical compound CCOC1=CC=CC=C1O[C@@H](C=1C=CC=CC=1)[C@H]1OCCNC1 CBQGYUDMJHNJBX-OALUTQOASA-N 0.000 claims 3
- 206010058019 Cancer Pain Diseases 0.000 claims 3
- 206010065390 Inflammatory pain Diseases 0.000 claims 3
- 208000001294 Nociceptive Pain Diseases 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000009935 visceral pain Diseases 0.000 claims 3
- 208000008035 Back Pain Diseases 0.000 claims 2
- 206010019233 Headaches Diseases 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 208000023178 Musculoskeletal disease Diseases 0.000 claims 2
- 206010065016 Post-traumatic pain Diseases 0.000 claims 2
- 208000004550 Postoperative Pain Diseases 0.000 claims 2
- 206010038419 Renal colic Diseases 0.000 claims 2
- 208000010040 Sprains and Strains Diseases 0.000 claims 2
- 208000005298 acute pain Diseases 0.000 claims 2
- 210000003169 central nervous system Anatomy 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 231100000869 headache Toxicity 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 230000003340 mental effect Effects 0.000 claims 2
- 230000036651 mood Effects 0.000 claims 2
- 210000000214 mouth Anatomy 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 208000032170 Congenital Abnormalities Diseases 0.000 claims 1
- 206010036376 Postherpetic Neuralgia Diseases 0.000 claims 1
- 229940126601 medicinal product Drugs 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0412878A GB0412878D0 (en) | 2004-06-09 | 2004-06-09 | Use |
| GB0412878.1 | 2004-06-09 | ||
| US58865204P | 2004-07-16 | 2004-07-16 | |
| US60/588,652 | 2004-07-16 | ||
| GB0425061.9 | 2004-11-12 | ||
| GB0425061A GB0425061D0 (en) | 2004-11-12 | 2004-11-12 | Use |
| US63442704P | 2004-12-07 | 2004-12-07 | |
| US60/634,427 | 2004-12-07 | ||
| PCT/IB2005/001904 WO2006000903A2 (en) | 2004-06-09 | 2005-05-27 | Use of reboxetine for the treatment of pain |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2006143659A true RU2006143659A (ru) | 2008-06-20 |
Family
ID=34979099
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006143659/152006143659/15A RU2006143659A (ru) | 2004-06-09 | 2005-05-27 | Применение ребоксетина для лечения боли |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20080261984A1 (https=) |
| EP (1) | EP1763354A2 (https=) |
| JP (1) | JP2008501778A (https=) |
| KR (1) | KR20070029740A (https=) |
| AU (1) | AU2005256944A1 (https=) |
| BR (1) | BRPI0511941A (https=) |
| CA (1) | CA2567365A1 (https=) |
| IL (1) | IL178827A0 (https=) |
| MX (1) | MXPA06014389A (https=) |
| NO (1) | NO20064642L (https=) |
| RU (1) | RU2006143659A (https=) |
| WO (1) | WO2006000903A2 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090233959A1 (en) | 2008-02-19 | 2009-09-17 | Adolor Corporation | Beloxepin and analogs for the treatment of pain |
| US9345689B2 (en) | 2012-05-18 | 2016-05-24 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N, N-dimethyl-4-phenyl-4,9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and an anticonvulsant |
| US9320725B2 (en) | 2012-05-18 | 2016-04-26 | Gruenenthal Gmbh | Pharmaceutical composition comprising (1r,4r)-6′-fluoro-N,N-dimethyl-4-phenyl-4′9′-dihydro-3′H-spiro[cyclohexane-1,1′-pyrano[3,4,b]indol]-4-amine and a gabapentinoid |
| US20130310385A1 (en) | 2012-05-18 | 2013-11-21 | Gruenenthal Gmbh | Pharmaceutical Composition Comprising (1r,4r)-6'-fluoro-N,N-dimethyl-4-phenyl-4',9'-dihydro-3'H-spiro[cyclohexane-1,1'-pyrano[3,4,b]indol]-4-amine and Antidepressants |
| KR20200144568A (ko) * | 2018-04-17 | 2020-12-29 | 상하이 통리엔 파마슈티컬 컴퍼니 리미티드 | 통증 및/또는 발열을 예방 및/또는 치료하는 의약품, 조합 산물 및 그 응용 |
| WO2019222850A1 (en) * | 2018-05-23 | 2019-11-28 | Wex Pharmaceuticals Inc. | Synergistic tetrodotoxin formulations and methods of treatment for neuropathic pain |
| WO2019245975A1 (en) * | 2018-06-17 | 2019-12-26 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
| US20190381056A1 (en) * | 2018-06-17 | 2019-12-19 | Axsome Therapeutics, Inc. | Compositions for delivery of reboxetine |
| WO2021113163A1 (en) * | 2019-12-03 | 2021-06-10 | Axsome Therapeutics, Inc. | Use of reboxetine to treat nervous system disorders |
| US20200147093A1 (en) | 2018-10-15 | 2020-05-14 | Axsome Therapeutics, Inc. | Use of esreboxetine to treat nervous system disorders such as fibromyalgia |
| US11020402B2 (en) | 2018-10-15 | 2021-06-01 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| IL282311B2 (en) * | 2018-10-15 | 2025-08-01 | Axsome Therapeutics Inc | Use of reboxetine to treat narcolepsy |
| US20240415842A1 (en) * | 2019-12-03 | 2024-12-19 | Axsome Therapeutics, Inc. | Use of reboxetine to treat narcolepsy |
| US12565478B1 (en) | 2025-01-21 | 2026-03-03 | Axsome Therapeutics, Inc. | (S)-2-((S)-(2-ethoxyphenoxy)(phenyl)methyl)-4-nitrosomorpholine |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US422449A (en) * | 1890-03-04 | Gage for gas-cocks | ||
| DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| US6465458B1 (en) * | 1999-07-01 | 2002-10-15 | Pharmacia & Upjohn Company | Method of treating or preventing chronic pain with a highly selective norepinephrine reuptake inhibitor |
| SI1196172T1 (sl) * | 1999-07-01 | 2006-06-30 | Pharmacia & Upjohn Co Llc | (S,S)-reboksetin za zdravljenje kronicne bolecine |
| US20040204411A1 (en) * | 2002-12-17 | 2004-10-14 | Pharmacia Corporation | Method for the treatment, prevention, or inhibition of a CNS disorder and/or pain and inflammation using a combination of reboxetine and a cyclooxygenase-2 selective inhibitor and compositions thereof |
| EP1667686A1 (en) * | 2003-09-09 | 2006-06-14 | Pfizer Products Inc. | Combination of serotonin reuptake inhibitors and norepinephrine reuptake inhibitors |
| NZ545494A (en) * | 2003-09-12 | 2009-10-30 | Pfizer | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
-
2005
- 2005-05-27 BR BRPI0511941-3A patent/BRPI0511941A/pt not_active IP Right Cessation
- 2005-05-27 JP JP2007526596A patent/JP2008501778A/ja not_active Withdrawn
- 2005-05-27 WO PCT/IB2005/001904 patent/WO2006000903A2/en not_active Ceased
- 2005-05-27 CA CA002567365A patent/CA2567365A1/en not_active Abandoned
- 2005-05-27 RU RU2006143659/152006143659/15A patent/RU2006143659A/ru not_active Application Discontinuation
- 2005-05-27 US US11/570,280 patent/US20080261984A1/en not_active Abandoned
- 2005-05-27 EP EP05758534A patent/EP1763354A2/en not_active Withdrawn
- 2005-05-27 MX MXPA06014389A patent/MXPA06014389A/es not_active Application Discontinuation
- 2005-05-27 AU AU2005256944A patent/AU2005256944A1/en not_active Abandoned
- 2005-05-27 KR KR1020067025877A patent/KR20070029740A/ko not_active Ceased
-
2006
- 2006-10-12 NO NO20064642A patent/NO20064642L/no not_active Application Discontinuation
- 2006-10-23 IL IL178827A patent/IL178827A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20064642L (no) | 2006-11-13 |
| BRPI0511941A (pt) | 2008-01-22 |
| KR20070029740A (ko) | 2007-03-14 |
| EP1763354A2 (en) | 2007-03-21 |
| US20080261984A1 (en) | 2008-10-23 |
| JP2008501778A (ja) | 2008-01-24 |
| WO2006000903A3 (en) | 2006-06-08 |
| AU2005256944A1 (en) | 2006-01-05 |
| MXPA06014389A (es) | 2007-02-19 |
| CA2567365A1 (en) | 2006-01-05 |
| IL178827A0 (en) | 2007-03-08 |
| WO2006000903A2 (en) | 2006-01-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20081223 |
|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20081223 |