RU2006136011A - СПОСОБЫ МОДУЛЯЦИИ ИММУННЫХ ОТВЕТОВ ПУТЕМ МОДУЛЯЦИИ ФУНКЦИЙ tim-1, tim-2 И tim-4 - Google Patents
СПОСОБЫ МОДУЛЯЦИИ ИММУННЫХ ОТВЕТОВ ПУТЕМ МОДУЛЯЦИИ ФУНКЦИЙ tim-1, tim-2 И tim-4 Download PDFInfo
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- RU2006136011A RU2006136011A RU2006136011/13A RU2006136011A RU2006136011A RU 2006136011 A RU2006136011 A RU 2006136011A RU 2006136011/13 A RU2006136011/13 A RU 2006136011/13A RU 2006136011 A RU2006136011 A RU 2006136011A RU 2006136011 A RU2006136011 A RU 2006136011A
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Classifications
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- G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/24—Immunology or allergic disorders
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
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- Bioinformatics & Cheminformatics (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Physics & Mathematics (AREA)
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- Communicable Diseases (AREA)
- Pulmonology (AREA)
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- Endocrinology (AREA)
- Oncology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55252304P | 2004-03-12 | 2004-03-12 | |
| US60/552,523 | 2004-03-12 | ||
| US62255904P | 2004-10-27 | 2004-10-27 | |
| US60/622,559 | 2004-10-27 |
Publications (1)
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| RU2006136011A true RU2006136011A (ru) | 2008-04-20 |
Family
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| RU2006136011/13A RU2006136011A (ru) | 2004-03-12 | 2005-03-14 | СПОСОБЫ МОДУЛЯЦИИ ИММУННЫХ ОТВЕТОВ ПУТЕМ МОДУЛЯЦИИ ФУНКЦИЙ tim-1, tim-2 И tim-4 |
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| JP (2) | JP4903128B2 (enExample) |
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| EA004402B1 (ru) * | 1996-05-24 | 2004-04-29 | Байоджен, Инк. | Модуляторы регенерации тканей |
| CN1835769B (zh) * | 2002-12-30 | 2011-06-29 | 比奥根艾迪克Ma公司 | Kim-1拮抗剂及其在免疫系统调节中的应用 |
| US20050276756A1 (en) * | 2004-03-24 | 2005-12-15 | Hoo William S | Compositions as adjuvants to improve immune responses to vaccines and methods of use |
| BRPI0608254A2 (pt) * | 2005-03-02 | 2009-12-08 | Biogen Idec Inc | anticorpos kim-1 para o tratamento de condições mediadas por th2 |
| WO2007101254A2 (en) * | 2006-02-28 | 2007-09-07 | Telos Pharmaceuticals Llc | Compositions and methods for the treatment of immune system disorders |
| WO2009064290A1 (en) * | 2007-11-13 | 2009-05-22 | Government Of The United States As Represented By The Secretary Of The Department Of Health And Human Services | Structure of tim family members |
| US20110091495A1 (en) * | 2008-04-22 | 2011-04-21 | Rutgers, The State University Of New Jersey | Hcv e2 construct compositions and methods |
| WO2009131572A1 (en) * | 2008-04-22 | 2009-10-29 | Government Of The U.S. As Represented By The Secretary Of The Department Of Health And Human Service | Structure of tim family members |
| US9758794B2 (en) | 2008-04-22 | 2017-09-12 | Rutgers, The State University Of New Jersey | HCV E2 construct compositions and methods |
| EP2808028B1 (en) * | 2011-11-21 | 2019-09-04 | University of Tsukuba | Activity modulator, medicinal agent comprising same, use of cd300a gene-deficient mouse, and anti-cd300a antibody |
| EP2918289A4 (en) | 2012-11-07 | 2016-06-15 | Univ Tsukuba | MEDICAMENT WITH MODULATOR OF THE ACTIVITY OF A CD300A EXPRESSIVE CELL RELATED TO ALLERGIC DISEASES, CD300A GENE KNOCKOUT MOUSE, AND USE OF A MODULATOR OF THE ACTIVITY OF A CD300A EXPRESSIVE CELL |
| US9651561B2 (en) | 2012-11-20 | 2017-05-16 | The Brigham And Womens's Hospital, Inc. | Diagnosis and treatment of endometriosis and related conditions |
| KR101510742B1 (ko) | 2013-05-13 | 2015-04-10 | (주)케어젠 | 비만세포―특이적 아팝토시스-유도용 펩타이드 및 이의 용도 |
| EP3148564B1 (en) * | 2014-06-02 | 2020-01-08 | Children's Medical Center Corporation | Methods and compositions for immunomodulation |
| JP7187151B2 (ja) * | 2015-04-10 | 2022-12-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 生存細胞の画像解析のための方法及び装置 |
| US20180153986A1 (en) * | 2015-04-24 | 2018-06-07 | The Brigham And Women's Hospital, Inc. | Interactions between ceacam and tim family members |
| WO2017197158A1 (en) * | 2016-05-11 | 2017-11-16 | Leuvas Therapeutics | Blockade of tim-1 pathways and p-selectin pathways in treatment of neuroinflammatory degenerative disease |
| WO2018009507A1 (en) | 2016-07-06 | 2018-01-11 | Bristol-Myers Squibb Company | Combination of tim-4 antagonist and methods of use |
| CA3035080A1 (en) | 2016-09-27 | 2018-04-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules |
| MA49122A (fr) * | 2017-04-10 | 2021-03-24 | Immatics Biotechnologies Gmbh | Peptides et combinaisons de peptides destinés à être utilisés en immunothérapie anticancéreuse |
| AU2018341244A1 (en) | 2017-09-26 | 2020-03-05 | Cero Therapeutics, Inc. | Chimeric engulfment receptor molecules and methods of use |
| EP3724230A4 (en) * | 2017-12-13 | 2022-01-19 | Yale University | Compositions and methods for treating or preventing endocrine fgf23-linked diseases |
| WO2019191334A1 (en) | 2018-03-28 | 2019-10-03 | Cero Therapeutics, Inc. | Chimeric tim4 receptors and uses thereof |
| CN112218887B (zh) | 2018-03-28 | 2025-12-12 | 森罗治疗控股公司 | 细胞免疫疗法组合物及其用途 |
| TW202305121A (zh) * | 2021-04-08 | 2023-02-01 | 日商武田藥品工業股份有限公司 | T細胞活化方法 |
| WO2025064933A1 (en) * | 2023-09-22 | 2025-03-27 | The Trustees Of Columbia University In The City Of New York | Restoring tim4 in liver macrophages to treat non-alcoholic steatohepatitis (nash) |
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| US6066322A (en) * | 1995-03-03 | 2000-05-23 | Millennium Pharmaceuticals, Inc. | Methods for the treatment of immune disorders |
| US6455685B1 (en) * | 1995-03-03 | 2002-09-24 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| US20030069196A1 (en) * | 1995-03-03 | 2003-04-10 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the treatment and diagnosis of immune disorders |
| US6027916A (en) * | 1996-10-09 | 2000-02-22 | Human Genome Sciences, Inc. | Galectin 9 and 10SV Polynucleotides |
| WO1998015624A1 (en) | 1996-10-09 | 1998-04-16 | Human Genome Sciences, Inc. | Galectin 8, 9, 10 and 10sv |
| US6190909B1 (en) * | 1997-04-17 | 2001-02-20 | Millennium Pharmaceuticals, Inc. | TH2-specific gene |
| AU1824499A (en) * | 1997-12-30 | 1999-07-19 | Chiron Corporation | Human cxc chemokine ((tim-1)) |
| EP1044211A4 (en) * | 1998-01-07 | 2005-03-23 | Human Genome Sciences Inc | 36 HUMAN SECRETATED PROTEINS |
| WO2001057188A2 (en) | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
| CA2394039A1 (en) | 2000-01-31 | 2001-08-02 | Human Genome Sciences, Inc. | Nucleic acids, proteins, and antibodies |
| AU2001240076A1 (en) * | 2000-03-08 | 2001-09-17 | National Jewish Medical And Research Center | Phosphatidyl serine receptors and uses thereof |
| WO2002081517A2 (en) | 2001-01-19 | 2002-10-17 | Curagen Corporation | Novel polypeptides and nucleic acids encoded thereby |
| US7838220B2 (en) * | 2001-06-29 | 2010-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes associated with immune disease |
| US7553939B2 (en) * | 2001-06-29 | 2009-06-30 | The Board Of Trustees Of The Leland Stanford Junior University | T cell regulatory genes and methods of use thereof |
| AU2003303082B2 (en) | 2002-01-30 | 2009-07-02 | Dana-Farber Cancer Institute, Inc. | Compositions and methods related to TIM-3, a Th1-specific cell surface molecule |
| DE10213762A1 (de) | 2002-03-26 | 2003-10-09 | Boehringer Ingelheim Int | Neues costimulierendes Molekül und dessen Verwendung |
| CN1835769B (zh) | 2002-12-30 | 2011-06-29 | 比奥根艾迪克Ma公司 | Kim-1拮抗剂及其在免疫系统调节中的应用 |
| CN1902227A (zh) * | 2003-10-03 | 2007-01-24 | 布赖汉姆妇女医院 | Tim-3配体及其方法 |
| US20050276756A1 (en) * | 2004-03-24 | 2005-12-15 | Hoo William S | Compositions as adjuvants to improve immune responses to vaccines and methods of use |
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2005
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- 2005-03-14 EP EP05732272.9A patent/EP1735445B1/en not_active Expired - Lifetime
- 2005-03-14 AU AU2005224634A patent/AU2005224634A1/en not_active Abandoned
- 2005-03-14 CN CN2012100590620A patent/CN102861319A/zh active Pending
- 2005-03-14 KR KR1020067021139A patent/KR20060130731A/ko not_active Withdrawn
- 2005-03-14 US US11/080,091 patent/US7741271B2/en not_active Expired - Lifetime
- 2005-03-14 MX MXPA06010419A patent/MXPA06010419A/es not_active Application Discontinuation
- 2005-03-14 JP JP2007503106A patent/JP4903128B2/ja not_active Expired - Fee Related
- 2005-03-14 WO PCT/US2005/008423 patent/WO2005090573A2/en not_active Ceased
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- 2005-03-14 RU RU2006136011/13A patent/RU2006136011A/ru not_active Application Discontinuation
- 2005-03-14 BR BRPI0508553-5A patent/BRPI0508553A/pt not_active IP Right Cessation
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2006
- 2006-09-11 IL IL178002A patent/IL178002A/en not_active IP Right Cessation
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2010
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2011
- 2011-11-24 JP JP2011255899A patent/JP2012070749A/ja active Pending
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2013
- 2013-01-25 US US13/750,092 patent/US20130195895A1/en not_active Abandoned
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2014
- 2014-10-01 US US14/503,768 patent/US20150079085A1/en not_active Abandoned
Also Published As
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| JP4903128B2 (ja) | 2012-03-28 |
| CN102861319A (zh) | 2013-01-09 |
| JP2012070749A (ja) | 2012-04-12 |
| US7741271B2 (en) | 2010-06-22 |
| CA2558371A1 (en) | 2005-09-29 |
| EP1735445A2 (en) | 2006-12-27 |
| AU2005224634A1 (en) | 2005-09-29 |
| JP2007529204A (ja) | 2007-10-25 |
| IL178002A (en) | 2011-12-29 |
| KR20060130731A (ko) | 2006-12-19 |
| CA2558371C (en) | 2013-08-27 |
| BRPI0508553A (pt) | 2007-08-07 |
| EP1735445B1 (en) | 2015-05-27 |
| IL178002A0 (en) | 2006-12-31 |
| US20110045002A1 (en) | 2011-02-24 |
| WO2005090573A3 (en) | 2006-01-12 |
| TW200539890A (en) | 2005-12-16 |
| US20130195895A1 (en) | 2013-08-01 |
| MXPA06010419A (es) | 2007-06-12 |
| WO2005090573A2 (en) | 2005-09-29 |
| US20050261224A1 (en) | 2005-11-24 |
| US20150079085A1 (en) | 2015-03-19 |
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| FA93 | Acknowledgement of application withdrawn (no request for examination) |
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