RU2006129090A - METHOD FOR OBTAINING SIBERIAPLAST PROTECTIVE ANTIGEN - Google Patents

METHOD FOR OBTAINING SIBERIAPLAST PROTECTIVE ANTIGEN Download PDF

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Publication number
RU2006129090A
RU2006129090A RU2006129090/13A RU2006129090A RU2006129090A RU 2006129090 A RU2006129090 A RU 2006129090A RU 2006129090/13 A RU2006129090/13 A RU 2006129090/13A RU 2006129090 A RU2006129090 A RU 2006129090A RU 2006129090 A RU2006129090 A RU 2006129090A
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RU
Russia
Prior art keywords
protective antigen
obtaining
siberiaplast
antigen
microfiltration
Prior art date
Application number
RU2006129090/13A
Other languages
Russian (ru)
Other versions
RU2340356C2 (en
Inventor
Александр Николаевич Шевцов (RU)
Александр Николаевич Шевцов
Владимир Сергеевич Лобастов (RU)
Владимир Сергеевич Лобастов
Денис Витальевич Боровской (RU)
Денис Витальевич Боровской
Виктор Алексеевич Меновщиков (RU)
Виктор Алексеевич Меновщиков
Николай Геннадьевич Хапаев (RU)
Николай Геннадьевич Хапаев
Original Assignee
Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" (RU)
Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации"
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Publication date
Application filed by Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" (RU), Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" filed Critical Федеральное государственное учреждение "48 Центральный научно-исследовательский институт Министерства обороны Российской Федерации" (RU)
Priority to RU2006129090/13A priority Critical patent/RU2340356C2/en
Publication of RU2006129090A publication Critical patent/RU2006129090A/en
Application granted granted Critical
Publication of RU2340356C2 publication Critical patent/RU2340356C2/en

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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Claims (1)

Способ получения сибиреязвенного протективного антигена, включающий получение протективного антигена в культуральной жидкости с последующим концентрированием, отличающийся тем, что при получении нативного ПА индуктор его синтеза вводят на протяжении экспоненциальной фазы роста вакцинного штамма, а выделение, концентрирование и стерилизацию ПА осуществляют на одной установке ультра- и микрофильтрации.A method for producing an anthrax protective antigen, including obtaining a protective antigen in a culture fluid followed by concentration, characterized in that when a native PA is obtained, its synthesis inducer is introduced during the exponential growth phase of the vaccine strain, and PA is isolated, concentrated and sterilized on a single ultra- and microfiltration.
RU2006129090/13A 2006-08-10 2006-08-10 Method of obtaining of anthracic protective antigen RU2340356C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2006129090/13A RU2340356C2 (en) 2006-08-10 2006-08-10 Method of obtaining of anthracic protective antigen

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2006129090/13A RU2340356C2 (en) 2006-08-10 2006-08-10 Method of obtaining of anthracic protective antigen

Publications (2)

Publication Number Publication Date
RU2006129090A true RU2006129090A (en) 2008-02-20
RU2340356C2 RU2340356C2 (en) 2008-12-10

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Family Applications (1)

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RU2006129090/13A RU2340356C2 (en) 2006-08-10 2006-08-10 Method of obtaining of anthracic protective antigen

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RU (1) RU2340356C2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2492241C1 (en) * 2012-07-10 2013-09-10 Федеральное казенное учреждение здравоохранения "Российский научно-исследовательский противочумный институт "Микроб" Федеральной службы по надзору в сфере защиты прав потребителей и благополучия человека ("РосНИПЧИ "Микроб") METHOD OF PRODUCTION OF PROTECTIVE ANTIGEN AND PROTEIN OF S-LAYER EA1OF ASPOROGENOUS RECOMBINANT STRAIN IN anthracis 55 ΔTPA-1Spo-

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Publication number Publication date
RU2340356C2 (en) 2008-12-10

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Legal Events

Date Code Title Description
PC43 Official registration of the transfer of the exclusive right without contract for inventions

Effective date: 20120510

MM4A The patent is invalid due to non-payment of fees

Effective date: 20140811