RU2006116896A - Терапевтический агент для мезотелиомы - Google Patents
Терапевтический агент для мезотелиомы Download PDFInfo
- Publication number
- RU2006116896A RU2006116896A RU2006116896/15A RU2006116896A RU2006116896A RU 2006116896 A RU2006116896 A RU 2006116896A RU 2006116896/15 A RU2006116896/15 A RU 2006116896/15A RU 2006116896 A RU2006116896 A RU 2006116896A RU 2006116896 A RU2006116896 A RU 2006116896A
- Authority
- RU
- Russia
- Prior art keywords
- antibody
- receptor
- mesothelioma
- therapeutic agent
- growth inhibitor
- Prior art date
Links
- 206010027406 Mesothelioma Diseases 0.000 title claims 16
- 239000003814 drug Substances 0.000 title claims 13
- 229940124597 therapeutic agent Drugs 0.000 title claims 13
- 102000010781 Interleukin-6 Receptors Human genes 0.000 claims 20
- 108010038501 Interleukin-6 Receptors Proteins 0.000 claims 16
- 239000003966 growth inhibitor Substances 0.000 claims 12
- 229940124103 Interleukin 6 antagonist Drugs 0.000 claims 6
- 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 claims 4
- 108090001005 Interleukin-6 Proteins 0.000 claims 4
- 102000004889 Interleukin-6 Human genes 0.000 claims 4
- 101001076414 Mus musculus Interleukin-6 Proteins 0.000 claims 4
- 206010035603 Pleural mesothelioma Diseases 0.000 claims 4
- 102000052611 human IL6 Human genes 0.000 claims 4
- 102000005962 receptors Human genes 0.000 claims 4
- 108020003175 receptors Proteins 0.000 claims 4
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000005557 antagonist Substances 0.000 claims 2
- 208000006178 malignant mesothelioma Diseases 0.000 claims 2
- 201000005282 malignant pleural mesothelioma Diseases 0.000 claims 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Mobile Radio Communication Systems (AREA)
Claims (24)
1. Терапевтический агент для мезотелиомы, который содержит антагонист интерлейкина-6(IL-6) в качестве его активного ингредиента.
2. Терапевтический агент для мезотелиомы по п.1, где мезотелиома является плевральной мезотелиомой.
3. Терапевтический агент для мезотелиомы по п.2, где плевральная мезотелиома является злокачественной плевральной мезотелиомой.
4. Терапевтический агент для мезотелиомы по любому из пп.1-3, где антагонистом IL-6 является антитело к IL-6-рецептору.
5. Терапевтический агент для мезотелиомы по п.4, где антителом к IL-6-рецептору является моноклональное антитело к IL-6-рецептору.
6. Терапевтический агент для мезотелиомы по п.4, где антителом к IL-6-рецептору является моноклональное антитело к IL-6-рецептору человека.
7. Терапевтический агент для мезотелиомы по п.4, где антителом к IL-6-рецептору является моноклональное антитело к IL-6-рецептору мыши.
8. Терапевтический агент для мезотелиомы по п.4, где антителом к IL-6-рецептору является рекомбинантное антитело.
9. Терапевтический агент для мезотелиомы по п.6, где моноклональным антителом к IL-6-рецептору человека является антитело РМ-1.
10. Терапевтический агент для мезотелиомы по п.7, где моноклональным антителом к IL-6-рецептору мыши является антитело MR16-1.
11. Терапевтический агент для мезотелиомы по п.4, где антителом к IL-6-рецептору является химерное антитело, гуманизированное антитело или человеческое антитело.
12. Терапевтический агент для мезотелиомы по п.11, где гуманизированным антителом к IL-6-рецептору является гуманизированное антитело РМ-1.
13. Ингибитор роста против клеток мезотелиомы, который содержит антагонист интерлейкина-6(IL-6) в качестве его активного ингредиента.
14. Ингибитор роста по п.13, где мезотелиома является плевральной мезотелиомой.
15. Ингибитор роста по п.14, где плевральная мезотелиома является злокачественной плевральной мезотелиомой.
16. Ингибитор роста по любому из пп.13-15, где антагонистом IL-6 является антитело к IL-6-рецептору.
17. Ингибитор роста по п.16, где антителом к IL-6-рецептору является моноклональное антитело к IL-6-рецептору.
18. Ингибитор роста по п.16, где антителом к IL-6-рецептору является моноклональное антитело к IL-6-рецептору человека.
19. Ингибитор роста по п.16, где антителом к IL-6-рецептору является моноклональное антитело к IL-6-рецептору мыши.
20. Ингибитор роста по п.16, где антителом к IL-6-рецептору является рекомбинантное антитело.
21. Ингибитор роста по п.18, где моноклональным антителом к IL-6-рецептору человека является антитело РМ-1.
22. Ингибитор роста по п.19, где моноклональным антителом к IL-6-рецептору мыши является антитело MR 16-1.
23. Ингибитор роста по п.16, где антителом к IL-6-рецептору является химерное антитело, гуманизированное антитело или человеческое антитело.
24. Ингибитор роста по п.23, где гуманизированным антителом к IL-6-рецептору является гуманизированное антитело РМ-1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003-358152 | 2003-10-17 | ||
JP2003358152 | 2003-10-17 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010102911/15A Division RU2554942C2 (ru) | 2003-10-17 | 2004-10-15 | Терапевтический агент для мезотелиомы |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2006116896A true RU2006116896A (ru) | 2007-12-10 |
RU2392967C2 RU2392967C2 (ru) | 2010-06-27 |
Family
ID=34463281
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2006116896/15A RU2392967C2 (ru) | 2003-10-17 | 2004-10-15 | Терапевтический агент для мезотелиомы |
RU2010102911/15A RU2554942C2 (ru) | 2003-10-17 | 2004-10-15 | Терапевтический агент для мезотелиомы |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2010102911/15A RU2554942C2 (ru) | 2003-10-17 | 2004-10-15 | Терапевтический агент для мезотелиомы |
Country Status (23)
Country | Link |
---|---|
US (2) | US20070134242A1 (ru) |
EP (1) | EP1690550B1 (ru) |
JP (1) | JP4651541B2 (ru) |
KR (1) | KR101193708B1 (ru) |
CN (1) | CN1874790B (ru) |
AR (1) | AR046290A1 (ru) |
AU (1) | AU2004281139B2 (ru) |
BR (1) | BRPI0415505A (ru) |
CA (1) | CA2542691C (ru) |
DK (1) | DK1690550T3 (ru) |
ES (1) | ES2392824T3 (ru) |
HK (1) | HK1096588A1 (ru) |
IL (1) | IL174909A (ru) |
MX (1) | MXPA06003768A (ru) |
MY (1) | MY149856A (ru) |
NO (1) | NO20061906L (ru) |
NZ (1) | NZ546557A (ru) |
PL (1) | PL1690550T3 (ru) |
RU (2) | RU2392967C2 (ru) |
SI (1) | SI1690550T1 (ru) |
TW (1) | TWI350175B (ru) |
WO (1) | WO2005037315A1 (ru) |
ZA (1) | ZA200602973B (ru) |
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