RU2005126057A - Оторинологическое доставляющее устройство - Google Patents

Оторинологическое доставляющее устройство Download PDF

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RU2005126057A
RU2005126057A RU2005126057/15A RU2005126057A RU2005126057A RU 2005126057 A RU2005126057 A RU 2005126057A RU 2005126057/15 A RU2005126057/15 A RU 2005126057/15A RU 2005126057 A RU2005126057 A RU 2005126057A RU 2005126057 A RU2005126057 A RU 2005126057A
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siloxane
use according
poly
elastomeric composition
groups
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RU2005126057/15A
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RU2334525C2 (ru
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Тимо ХААПАКУМПУ (FI)
Тимо ХААПАКУМПУ
Харри ЮКАРАЙНЕН (FI)
Харри Юкарайнен
Юха АЛА-СОРВАРИ (FI)
Юха АЛА-СОРВАРИ
Хенри РАНКОНЕН (FI)
Хенри РАНКОНЕН
Фредерик Е РИФАГЕН (BE)
Фредерик Е РИФАГЕН
Вольфганг АРНОЛЬД (DE)
Вольфганг АРНОЛЬД
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Шеринг Ой (Fi)
Шеринг Ой
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0046—Ear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/04—Macromolecular materials
    • A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/16—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Otolaryngology (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Claims (10)

1. Применение эластомерной композиции, выбранной из группы, состоящей из поли(диметилсилоксана), эластомера на основе силоксана, включающего 3,3,3-трифторпропильные группы, присоединенные к атому Si силоксановых фрагментов, эластомера на основе силоксана, включающего поли(алкиленоксид)ные группы, и их смесей, для изготовления оторинологического доставляющего устройства, содержащего по меньшей мере один фармацевтически активный агент, где устройство включает ядро, содержащее указанный по меньшей мере один фармацевтически активный агент, где указанное ядро изготавливается из указанной эластомерной композиции, и мембрану, окружающую указанное ядро, где указанная мембрана изготовлена из такой же эластомерной композиции, что и указанное ядро, или из отличающейся эластомерной композиции, причем указанную эластомерную композицию указанной мембраны выбирают из указанной группы, и где фармацевтически активный агент выбирают из группы, включающей противоаллергические агенты, противоинфекционные агенты, противоастматические агенты, противовоспалительные агенты, противовирусные агенты, антибактериальные агенты, антигистаминные средства, противогрибковые агенты, лекарства против головокружения, анестетики, опиоиды, сосудорасширяющие, мускариновые агенты, симпатомиметики, кортикостероиды и их смеси.
2. Применение по п.1, отличающееся тем, что указанная эластомерная композиция содержит эластомер на основе силоксана, включающий 3,3,3-трифторпропильные группы, присоединенные к атому Si силоксановых фрагментов, и в указанном эластомере на основе силоксана от 1 до 49,5% заместителей, присоединенных к атомам Si силоксановых фрагментов являются 3,3,3-трифторпропильными группами.
3. Применение по п.1, отличающееся тем, что указанная эластомерная композиция содержит эластомер на основе силоксана, включающий поли(алкиленоксид)ные группы, и указанные поли(алкиленоксид)ные группы присутствуют в виде прививок или блоков с конечными алкокси-группами, присоединенных к полисилоксановым фрагментам связями кремний-углерод, или в виде смеси данных форм.
4. Применение по п.3, отличающееся тем, что указанные поли(алкиленоксид)ные группы являются поли(этиленоксид)ными группами
5. Применение по п.1, отличающееся тем, что указанная мембрана и указанное ядро изготовлены из одинаковой эластомерной композиции.
6. Применение по п.1, отличающееся тем, что указанная мембрана и указанное ядро изготовлены из разных эластомерных композиций.
7. Применение по п.1, отличающееся тем, что указанное устройство является отологическим доставляющим устройством, а эластомерная композиция содержит поли(диметилсилоксан) и эластомер на основе силоксана, включающий поли(этиленоксид)ные группы.
8. Применение по п.1, отличающееся тем, что фармацевтически активный агент выбирают из группы, включающей дексаметазон, бетаметазон, беклометазон, будезонид и их смеси.
9. Применение по п.1, отличающееся тем, что указанное устройство предназначено для лечения отологических расстройств, выбранных из группы, состоящей из отита, острых инфекций, кохлеарных и вестибулярных расстройств, головокружения, болезни Меньера, внезапной глухоты, сенсонейронной потери слуха, звона в ушах, морской болезни, эндолимфатического отека, эндолимфатической гипертензии, перилимфатической гипертензии, перилимфатического отека, перилимфатического свища, интракохлеарного свища и разрывов различных мембранных структур внутри уха.
10. Применение по п.1, отличающееся тем, что указанное устройство предназначено для лечения назальных расстройств, выбранных из группы, состоящей из назальных воспалительных расстройств, аллергических реакций, астмы и грибковых инфекций.
RU2005126057/15A 2003-01-17 2004-01-14 Оторинологическое доставляющее устройство RU2334525C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03000987A EP1438942A1 (en) 2003-01-17 2003-01-17 An otorhinological drug delivery device
EP03000987.2 2003-01-17

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RU2005126057A true RU2005126057A (ru) 2006-01-10
RU2334525C2 RU2334525C2 (ru) 2008-09-27

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US (1) US7294345B2 (ru)
EP (1) EP1438942A1 (ru)
JP (1) JP2006516558A (ru)
CN (1) CN100490915C (ru)
AU (1) AU2004206755B2 (ru)
CA (1) CA2513544C (ru)
FI (1) FI7658U1 (ru)
NO (1) NO20053849L (ru)
RU (1) RU2334525C2 (ru)
WO (1) WO2004064912A1 (ru)

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US7294345B2 (en) 2007-11-13
WO2004064912A8 (en) 2004-09-30
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CN1767870A (zh) 2006-05-03
CA2513544A1 (en) 2004-08-05
RU2334525C2 (ru) 2008-09-27
CN100490915C (zh) 2009-05-27
NO20053849L (no) 2005-08-16
AU2004206755A1 (en) 2004-08-05
JP2006516558A (ja) 2006-07-06
AU2004206755B2 (en) 2008-01-17
FIU20070132U0 (fi) 2007-03-26
CA2513544C (en) 2012-08-07
US20060067982A1 (en) 2006-03-30
EP1438942A1 (en) 2004-07-21

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