RU2003102446A - NEW POLYCYCLIC XANTONES AND THEIR APPLICATION - Google Patents

NEW POLYCYCLIC XANTONES AND THEIR APPLICATION

Info

Publication number
RU2003102446A
RU2003102446A RU2003102446/04A RU2003102446A RU2003102446A RU 2003102446 A RU2003102446 A RU 2003102446A RU 2003102446/04 A RU2003102446/04 A RU 2003102446/04A RU 2003102446 A RU2003102446 A RU 2003102446A RU 2003102446 A RU2003102446 A RU 2003102446A
Authority
RU
Russia
Prior art keywords
compound
strain
alkyl
hydrogen
pharmaceutically acceptable
Prior art date
Application number
RU2003102446/04A
Other languages
Russian (ru)
Other versions
RU2285008C2 (en
Inventor
Хулия ПЕРЕС-БАС
Либрада Мария Каньедо
ГРАВАЛОС Долорес ГАРСИА
Франсиско РОМЕРО
Фернандо ЭСПЛИЕГО
Original Assignee
Институто Биомар С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB0016020.0A external-priority patent/GB0016020D0/en
Application filed by Институто Биомар С.А. filed Critical Институто Биомар С.А.
Publication of RU2003102446A publication Critical patent/RU2003102446A/en
Application granted granted Critical
Publication of RU2285008C2 publication Critical patent/RU2285008C2/en

Links

Claims (8)

1. Соединение общей формулы1. The compound of General formula
Figure 00000001
Figure 00000001
 илиor
Figure 00000002
Figure 00000002
 где каждый заместитель R1 является одинаковым или различным и может представлять собой водород, ацил, алкил, алкенил, арил, бензил, щелочной металл и/или сахар, а R2 и R3 могут представлять собой водород, алкил или образовывать вместе ненасыщенную связь.wherein each R 1 substituent is the same or different and may be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal and / or sugar, and R 2 and R 3 may be hydrogen, alkyl or together form an unsaturated bond. 2. Соединение по п.1 формулы2. The compound according to claim 1 of the formula
Figure 00000003
Figure 00000003
 3. Способ получения соединения IB-00208, который включает культивирование штамма микроорганизма, способного его продуцировать в водной питательной среде.3. The method of obtaining compounds IB-00208, which includes the cultivation of a strain of a microorganism capable of producing it in an aqueous nutrient medium. 4. Способ по п.3, который дополнительно включает выделение и очистку соединения IB-00208 из культурального бульона.4. The method according to claim 3, which further includes the isolation and purification of compound IB-00208 from the culture broth. 5. Способ по п.4, где продуцирующий соединение IB-00208 микроорганизм представляет собой по существу чистый штамм культуры PO13-046, имеющийся в распоряжении под номером доступа CECT 5318 в Colecciyn Espanola de Cultivos Tipo Университета Валенсии, Испания.5. The method according to claim 4, where the compound-producing IB-00208 microorganism is a substantially pure culture strain PO13-046, available under accession number CECT 5318 at Colecciyn Espanola de Cultivos Tipo of the University of Valencia, Spain. 6. Штамм культуры PO13-046, по существу чистый, выделенный из морских беспозвоночных, принадлежащих к семейству Thermomonosporaceae и таксономически классифицированный как Actinomadura sp.6. Culture strain PO13-046, essentially pure, isolated from marine invertebrates belonging to the Thermomonosporaceae family and taxonomically classified as Actinomadura sp. 7. Противоопухолевая фармацевтическая композция, включающая соединение по п.1 и фармацевтически приемлемый носитель.7. An antitumor pharmaceutical composition comprising a compound according to claim 1 and a pharmaceutically acceptable carrier. 8. Противоопухолевая фармацевтическая композция, включающая соединение IB-00208 по п.2 и фармацевтически приемлемый носитель.8. An antitumor pharmaceutical composition comprising compound IB-00208 according to claim 2 and a pharmaceutically acceptable carrier.
RU2003102446/04A 2000-06-29 2001-06-29 Novel polycyclic xanthones and their using RU2285008C2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB00/6020.0 2000-06-29
GB0016020.0 2000-06-29
GBGB0016020.0A GB0016020D0 (en) 2000-06-29 2000-06-29 New polyciclic xanthones and their use

Publications (2)

Publication Number Publication Date
RU2003102446A true RU2003102446A (en) 2004-07-20
RU2285008C2 RU2285008C2 (en) 2006-10-10

Family

ID=9894705

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003102446/04A RU2285008C2 (en) 2000-06-29 2001-06-29 Novel polycyclic xanthones and their using

Country Status (21)

Country Link
US (1) US6812245B2 (en)
EP (1) EP1296989B1 (en)
JP (1) JP2004501924A (en)
KR (1) KR100801068B1 (en)
CN (1) CN1273470C (en)
AT (1) ATE362935T1 (en)
AU (2) AU6620601A (en)
BR (1) BR0112090A (en)
CA (1) CA2412559A1 (en)
CY (1) CY1106805T1 (en)
DE (1) DE60128565T2 (en)
DK (1) DK1296989T3 (en)
ES (1) ES2287135T3 (en)
GB (1) GB0016020D0 (en)
HK (1) HK1052707B (en)
IL (2) IL153679A0 (en)
MX (1) MXPA03000199A (en)
NZ (1) NZ523338A (en)
PT (1) PT1296989E (en)
RU (1) RU2285008C2 (en)
WO (1) WO2002000663A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101372538B (en) 2007-08-21 2012-08-29 北京万和芯源生物技术有限公司 Ultraviolet light assisted surface modification method and product with surface formed thereby
WO2009085360A2 (en) * 2007-10-04 2009-07-09 Novobiotic Pharmaceuticals Llc Citreamicin antibiotic with a sugar residue
WO2009085359A2 (en) * 2007-10-04 2009-07-09 Novobiotic Pharmaceuticals Llc Citreamicin antibiotic isolated from nocardia
CN101889998B (en) * 2010-05-28 2012-10-03 暨南大学 Composition and application thereof as TR3 receptor inducer
JOP20190254A1 (en) 2017-04-27 2019-10-27 Pharma Mar Sa Antitumoral compounds
CN110627640B (en) * 2017-09-19 2020-10-30 浙江大学 Preparation and medical application of streptomyces xanthioides acid and streptomyces xanthione
CN109320527B (en) * 2018-11-12 2020-08-28 中国医学科学院医药生物技术研究所 Cervidomycin (Cervinomycin) B1, B2, B3 and B4, and production method and application thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS57102897A (en) 1980-12-17 1982-06-26 Kitasato Inst:The Antibiotic am-5344-a2 and its preparation
JPH0755951B2 (en) * 1986-02-17 1995-06-14 北里研究所（社団法人） Cerbinomycin antibiotic derivative and method for producing the same
JPS62270527A (en) * 1986-05-16 1987-11-24 Taiho Yakuhin Kogyo Kk Antitumor agent containing 4181-2 substance and its derivative
AU599650B2 (en) * 1986-05-16 1990-07-26 Taiho Pharmaceutical Co., Ltd. Substance 4181-2 and its derivatives
JPS62270587A (en) * 1986-05-16 1987-11-24 Taiho Yakuhin Kogyo Kk 4181-2 substance and acyl derivative thereof
US5223430A (en) * 1988-08-04 1993-06-29 American Cyanamid Company Subspecies of micromonospora citrea which produces antibiotic ll-e19085 alpha
EP0353381A3 (en) * 1988-08-04 1991-01-02 American Cyanamid Company Antibiotic ll-e19085 alpha
US5096907A (en) * 1989-06-29 1992-03-17 American Cyanamid Company Antibiotic LL-E19085
EP0405151A1 (en) * 1989-06-29 1991-01-02 American Cyanamid Company Antibiotic LL-E19085
EP0442003A1 (en) * 1990-02-13 1991-08-21 American Cyanamid Company Antibiotic LL-E 19085 alpha
GB0011927D0 (en) 2000-05-17 2000-07-05 Inst Biomar Sa New use of citreamicins

Similar Documents

Publication Publication Date Title
EP0535941B1 (en) Process for production of 8,11-eicosadienoic acid
RU2003102446A (en) NEW POLYCYCLIC XANTONES AND THEIR APPLICATION
EP1437359A3 (en) Novel 3,6-Hemiketals from the Class of 9a-Azalides
KR970043038A (en) STREPTOMYCESEXFOLIATUS YJ-118 and Method for Preparing Sodium Pravastatin
US4293485A (en) Derivatives of S31794/F-1 nucleus
AU7868400A (en) Neutral-cationic lipid for nucleic acid and drug delivery
CA2445651A1 (en) Cathartic composition comprising halogenated prostaglandin derivatives
IL172538A (en) Depsipeptide compounds, pharmaceutical compositions containing the same and processes for the preparation thereof
KR20010033413A (en) Novel substances kf-1040 and process for producing the same
JP2012512224A (en) Macrolactone derivatives, methods for their preparation, and their use for the treatment of cancer
KR930017886A (en) Aldose reductase inhibitors
CN1273470C (en) Polycyclic xanthones as antibiotics
EP0813531B1 (en) Antitumour isocoumarins
RU2001114212A (en) COMPOUND WK-5344A AND COMPOUND WK-5344B, METHOD FOR PRODUCING THEM AND PRODUCING THEIR STREPTOMYCES SP. WK-5344 FERM BP-6668
JP2011116662A (en) New antibiotic sf2876 substance, method for producing the same, and pharmaceutical composition
RU2001116104A (en) Vancorezmycin, a method for its preparation and its use as a medicine
KR880008972A (en) Carboxylic acid derivatives
RU2006117769A (en) BENGAMIDE DERIVATIVES, METHOD FOR PRODUCING THEM AND THEIR APPLICATION FOR TREATMENT OF CANCER DISEASES
JP4836783B2 (en) Antitumor agent, method for producing antitumor agent, pharmaceutical composition containing antitumor agent, and antitumor agent-producing bacterium
JPWO2002026744A1 (en) MPC1001 derivative
ES2318179T3 (en) STEREOSELECTIVE PROCEDURE FOR THE PRODUCTION OF DIOXOLAN NUCLEOSIDE ANALOGS.
JPH0246294A (en) Production of angnocyclinone from streptomyces microorganism and production thereof
JP4443740B2 (en) Anthracycline antibiotics
CN1095418A (en) Produce 6 β, 14 alpha-dihydroxy-s-4-androstene-3, the method for 17-diketone
JPH0984591A (en) Carotenoid sulfate and its production