RU2002135270A - METHOD FOR PRODUCING 1-AMINO-3,5, -DIMETHYL ADAMANT HYDROCHLORIDE - Google Patents

METHOD FOR PRODUCING 1-AMINO-3,5, -DIMETHYL ADAMANT HYDROCHLORIDE

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Publication number
RU2002135270A
RU2002135270A RU2002135270/04A RU2002135270A RU2002135270A RU 2002135270 A RU2002135270 A RU 2002135270A RU 2002135270/04 A RU2002135270/04 A RU 2002135270/04A RU 2002135270 A RU2002135270 A RU 2002135270A RU 2002135270 A RU2002135270 A RU 2002135270A
Authority
RU
Russia
Prior art keywords
amino
hydrochloride
dimethyladamantane
producing
urea
Prior art date
Application number
RU2002135270/04A
Other languages
Russian (ru)
Other versions
RU2246482C2 (en
Inventor
Юрий Николаевич Климочкин
Марина Валентиновна Леонова
Алла Константиновна Тимофеева
Original Assignee
ООО "Циклан"
АО "Олайнский химико-фармацевтический завод"
Filing date
Publication date
Application filed by ООО "Циклан", АО "Олайнский химико-фармацевтический завод" filed Critical ООО "Циклан"
Priority to RU2002135270/04A priority Critical patent/RU2246482C2/en
Priority claimed from RU2002135270/04A external-priority patent/RU2246482C2/en
Publication of RU2002135270A publication Critical patent/RU2002135270A/en
Application granted granted Critical
Publication of RU2246482C2 publication Critical patent/RU2246482C2/en

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Claims (1)

Способ получения гидрохлорида 1-амино-3,5-диметиладамантана реакцией 1,3-диметиладамантана с азотной кислотой с последующим добавлением мочевины и нагреванием реакционной массы, отличающийся тем, что добавление азотной кислоты ведут при 10-30°С к предварительно полученной эмульсии исходного углеводорода в уксусной кислоте, далее добавляют 30-55%-ый раствор карбамида в воде в мольном соотношении 1,3-диметиладамантан - уксусная кислота - азотная кислота - мочевина 1:3-4:9-12:2,5-5,0 соответственно, а выделение целевого продукта осуществляют путем нейтрализации реакционной массы 30-45%-ым раствором едкого натра, экстракцией толуолом при 50-85°С, добавлением концентрированной соляной кислоты, фильтрованием и дальнейшей перекристаллизацией гидрохлорида 1-амино-3,5-диметиладамантана из воды.The method of producing 1-amino-3,5-dimethyladamantane hydrochloride by reacting 1,3-dimethyladamantane with nitric acid followed by the addition of urea and heating the reaction mass, characterized in that the addition of nitric acid is carried out at 10-30 ° C. to the previously obtained emulsion of the initial hydrocarbon in acetic acid, then add a 30-55% solution of urea in water in a molar ratio of 1,3-dimethyladamantane - acetic acid - nitric acid - urea 1: 3-4: 9-12: 2.5-5.0, respectively and the selection of the target product is carried out by neutral lysing the reaction mass with a 30-45% sodium hydroxide solution, extraction with toluene at 50-85 ° C, adding concentrated hydrochloric acid, filtering and further recrystallizing 1-amino-3,5-dimethyladamantane hydrochloride from water.
RU2002135270/04A 2002-12-25 2002-12-25 Method for preparing 1-amino-3,5-dimethyladamantane hydrochloride RU2246482C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2002135270/04A RU2246482C2 (en) 2002-12-25 2002-12-25 Method for preparing 1-amino-3,5-dimethyladamantane hydrochloride

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002135270/04A RU2246482C2 (en) 2002-12-25 2002-12-25 Method for preparing 1-amino-3,5-dimethyladamantane hydrochloride

Publications (2)

Publication Number Publication Date
RU2002135270A true RU2002135270A (en) 2004-07-10
RU2246482C2 RU2246482C2 (en) 2005-02-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002135270/04A RU2246482C2 (en) 2002-12-25 2002-12-25 Method for preparing 1-amino-3,5-dimethyladamantane hydrochloride

Country Status (1)

Country Link
RU (1) RU2246482C2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2455281C2 (en) * 2006-03-01 2012-07-10 Мерц Фарма Гмбх Унд Ко. Кгаа Method of producing 1-formamido-3,5-dimethyladamantane

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005069742A2 (en) * 2003-12-10 2005-08-04 Sun Pharmaceutical Industries Limited Crystal form ii of memantine hydrochloride
PL1820792T3 (en) 2006-02-21 2012-06-29 Hexal Ag Process for the preparation of adamantanamines
RU2541545C2 (en) * 2013-03-29 2015-02-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования Самарский государственный технический университет Method of obtaining hydrochlorides of adamantane amines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2455281C2 (en) * 2006-03-01 2012-07-10 Мерц Фарма Гмбх Унд Ко. Кгаа Method of producing 1-formamido-3,5-dimethyladamantane

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