RU2002129262A - METHOD FOR PRODUCING LIPOSOMAL DRUGS - Google Patents

METHOD FOR PRODUCING LIPOSOMAL DRUGS

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Publication number
RU2002129262A
RU2002129262A RU2002129262/15A RU2002129262A RU2002129262A RU 2002129262 A RU2002129262 A RU 2002129262A RU 2002129262/15 A RU2002129262/15 A RU 2002129262/15A RU 2002129262 A RU2002129262 A RU 2002129262A RU 2002129262 A RU2002129262 A RU 2002129262A
Authority
RU
Russia
Prior art keywords
proliposomes
biologically active
phospholipids
active substance
drying
Prior art date
Application number
RU2002129262/15A
Other languages
Russian (ru)
Other versions
RU2217129C1 (en
Inventor
Евгений Михайлович Сорокин
Людмила Федоровна Смирнова
Ольга Геннадьевна Михайлова
Юлия Александровна Морозова
Александр Митрофанович Ищенко
Юрий Васильевич Тяготин
Виктор Леонидович Искрицкий
Евгений Николаевич Свентицкий
Original Assignee
Государственный научно-исследовательский институт особо чистых биопрепаратов
Filing date
Publication date
Application filed by Государственный научно-исследовательский институт особо чистых биопрепаратов filed Critical Государственный научно-исследовательский институт особо чистых биопрепаратов
Priority to RU2002129262/14A priority Critical patent/RU2217129C1/en
Priority claimed from RU2002129262/14A external-priority patent/RU2217129C1/en
Application granted granted Critical
Publication of RU2217129C1 publication Critical patent/RU2217129C1/en
Publication of RU2002129262A publication Critical patent/RU2002129262A/en

Links

Claims (5)

1. Способ получения липосомальных препаратов путем получения пролипосом смешиванием фосфолипидов, органического растворителя и наполнителя, введение в пролипосомы биологически активного начала и сушки пролипосом, отличающийся тем, что биологически активное начало вводят в пролипосомы путем смешения сухих пролипосом с раствором биологически активного вещества в полярном растворителе, а сушку пролипосом проводят в два этапа - до и после введения в пролипосомы биологически активного вещества.1. A method of producing liposomal preparations by preparing proliposomes by mixing phospholipids, an organic solvent and an excipient, introducing a biologically active principle into the proliposomes and drying the proliposomes, characterized in that the biologically active principle is introduced into the proliposomes by mixing dry proliposomes with a solution of the biologically active substance in a polar solvent, and drying proliposomes is carried out in two stages - before and after the introduction of a biologically active substance into proliposomes. 2. Способ по п.1, отличающийся тем, что в качестве биологически активного вещества используют белковые препараты или ферменты.2. The method according to claim 1, characterized in that protein preparations or enzymes are used as the biologically active substance. 3. Способ по пп.1 и 2, отличающийся тем, что концентрация биологически активных веществ в водных растворах составляет от 0,01 до 5,0 мг/мл.3. The method according to claims 1 and 2, characterized in that the concentration of biologically active substances in aqueous solutions is from 0.01 to 5.0 mg / ml 4. Способ по п.1, отличающийся тем, что в качестве фосфолипидов используют индивидуальные фосфолипиды или их смеси.4. The method according to claim 1, characterized in that as phospholipids use individual phospholipids or mixtures thereof. 5. Способ по п.1, отличающийся тем, что в качестве наполнителя используют сахара, и/или полисахариды, и/или полиолы, и/или соли.5. The method according to claim 1, characterized in that sugars and / or polysaccharides and / or polyols and / or salts are used as filler.
RU2002129262/14A 2002-10-28 2002-10-28 Method for preparing liposomal preparations RU2217129C1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2002129262/14A RU2217129C1 (en) 2002-10-28 2002-10-28 Method for preparing liposomal preparations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002129262/14A RU2217129C1 (en) 2002-10-28 2002-10-28 Method for preparing liposomal preparations

Publications (2)

Publication Number Publication Date
RU2217129C1 RU2217129C1 (en) 2003-11-27
RU2002129262A true RU2002129262A (en) 2004-04-27

Family

ID=32028266

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002129262/14A RU2217129C1 (en) 2002-10-28 2002-10-28 Method for preparing liposomal preparations

Country Status (1)

Country Link
RU (1) RU2217129C1 (en)

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