RU2002122722A - Пептиды tpl и кодирующие их днк-последовательности - Google Patents
Пептиды tpl и кодирующие их днк-последовательностиInfo
- Publication number
- RU2002122722A RU2002122722A RU2002122722/13A RU2002122722A RU2002122722A RU 2002122722 A RU2002122722 A RU 2002122722A RU 2002122722/13 A RU2002122722/13 A RU 2002122722/13A RU 2002122722 A RU2002122722 A RU 2002122722A RU 2002122722 A RU2002122722 A RU 2002122722A
- Authority
- RU
- Russia
- Prior art keywords
- encoding
- nucleic acid
- pharmaceutical composition
- tpl
- peptides
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims 5
- 108091028043 Nucleic acid sequence Proteins 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 150000007523 nucleic acids Chemical class 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000037841 lung tumor Diseases 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Claims (9)
1. Молекула нуклеиновой кислоты, кодирующая пептид TLP, имеющий последовательность SEQ ID NO:2.
2. Молекула нуклеиновой кислоты по п.1, имеющая последовательность SEQ ID NO:1.
3. Пептид, происходящий от SEQ ID NO:2.
4. Моноклональные или поликлональные антитела против пептида по п.3.
5. Вектор, содержащий молекулы нуклеиновой кислоты по п.1 или 2.
6. Фармацевтическая композиция, включающая молекулы нуклеиновой кислоты или пептид по пп.1 и 2 и соответственно 3.
7. Фармацевтическая композиция по п.6 в форме вакцины.
8. Фармацевтическая композиция по пп.6 и 7, используемая для предупреждения или лечения опухолей.
9. Фармацевтическая композиция по п.8, используемая для предупреждения или лечения опухолей легких.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2000A000344 | 2000-02-25 | ||
| IT2000MI000344A IT1317853B1 (it) | 2000-02-25 | 2000-02-25 | Peptidi tlp e sequenze di dna che li codificano. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2002122722A true RU2002122722A (ru) | 2004-03-27 |
Family
ID=11444175
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002122722/13A RU2002122722A (ru) | 2000-02-25 | 2001-02-20 | Пептиды tpl и кодирующие их днк-последовательности |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1265917A2 (ru) |
| JP (1) | JP2003523759A (ru) |
| KR (1) | KR20020086564A (ru) |
| AU (1) | AU4063401A (ru) |
| BR (1) | BR0108557A (ru) |
| CA (1) | CA2401031A1 (ru) |
| IT (1) | IT1317853B1 (ru) |
| RU (1) | RU2002122722A (ru) |
| WO (1) | WO2001062786A2 (ru) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2593086A1 (en) | 2004-12-30 | 2006-07-06 | Vito Michele Fazio | Anti-tumoral immunogenic peptides and vaccine thereof |
| ITRM20100256A1 (it) * | 2010-05-19 | 2011-11-20 | Farmafin Spa | Un nuovo biomarcatore per la diagnosi precoce e l'immunoterapia del cancro |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1262954B (it) * | 1992-07-03 | 1996-07-23 | Ist Farmacoterapico It Spa | Regioni antigeniche dei complessi tpl e anticorpi diretti contro di essi. |
| IT1294967B1 (it) * | 1996-10-09 | 1999-04-23 | Ist Farmacoterapico It Spa | Composizione immunogenica da tlp |
-
2000
- 2000-02-25 IT IT2000MI000344A patent/IT1317853B1/it active
-
2001
- 2001-02-20 KR KR1020027010999A patent/KR20020086564A/ko not_active Application Discontinuation
- 2001-02-20 JP JP2001562567A patent/JP2003523759A/ja active Pending
- 2001-02-20 AU AU40634/01A patent/AU4063401A/en not_active Abandoned
- 2001-02-20 EP EP01911660A patent/EP1265917A2/en not_active Withdrawn
- 2001-02-20 CA CA002401031A patent/CA2401031A1/en not_active Abandoned
- 2001-02-20 BR BR0108557-3A patent/BR0108557A/pt not_active Application Discontinuation
- 2001-02-20 WO PCT/EP2001/001857 patent/WO2001062786A2/en not_active Application Discontinuation
- 2001-02-20 RU RU2002122722/13A patent/RU2002122722A/ru unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1265917A2 (en) | 2002-12-18 |
| WO2001062786A3 (en) | 2002-01-17 |
| CA2401031A1 (en) | 2001-08-30 |
| ITMI20000344A0 (it) | 2000-02-25 |
| AU4063401A (en) | 2001-09-03 |
| JP2003523759A (ja) | 2003-08-12 |
| BR0108557A (pt) | 2003-04-29 |
| WO2001062786A2 (en) | 2001-08-30 |
| KR20020086564A (ko) | 2002-11-18 |
| ITMI20000344A1 (it) | 2001-08-25 |
| IT1317853B1 (it) | 2003-07-15 |
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