RU2002114254A - METHOD FOR DIFFERENTIAL DIAGNOSTICS OF VIRAL HEPATITIS C - Google Patents

METHOD FOR DIFFERENTIAL DIAGNOSTICS OF VIRAL HEPATITIS C

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Publication number
RU2002114254A
RU2002114254A RU2002114254/14A RU2002114254A RU2002114254A RU 2002114254 A RU2002114254 A RU 2002114254A RU 2002114254/14 A RU2002114254/14 A RU 2002114254/14A RU 2002114254 A RU2002114254 A RU 2002114254A RU 2002114254 A RU2002114254 A RU 2002114254A
Authority
RU
Russia
Prior art keywords
viral hepatitis
antibodies
differential diagnostics
determined
hepatitis
Prior art date
Application number
RU2002114254/14A
Other languages
Russian (ru)
Other versions
RU2226694C2 (en
Inventor
Олег Алексеевич Аксенов
Анна Львовна Мукомолова
чева Лариса Георгиевна Гор
Лариса Георгиевна Горячева
Натали Владимировна Рогозина
Наталия Владимировна Рогозина
Александр Александрович Колобов
Original Assignee
Научно-исследовательский институт детских инфекций
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Научно-исследовательский институт детских инфекций filed Critical Научно-исследовательский институт детских инфекций
Priority to RU2002114254/14A priority Critical patent/RU2226694C2/en
Publication of RU2002114254A publication Critical patent/RU2002114254A/en
Application granted granted Critical
Publication of RU2226694C2 publication Critical patent/RU2226694C2/en

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  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (1)

Способ дифференциальной диагностики вирусного гепатита С путем выявления антител и специфических иммунных комплексов, отличающийся тем, что в иммуноферментном тесте определяют антитела к неструктурным белкам (NS4) как в свободном виде, так и в составе иммунных комплексов, промывают параллельно буферным раствором и 6М раствором мочевины, затем определяют авидность этих антител и дифференцируют острую форму гепатита С по увеличению уровня антител на ≥12%, а хроническую форму по уменьшению их в пределах 50-90%.A method for the differential diagnosis of viral hepatitis C by detecting antibodies and specific immune complexes, characterized in that antibodies to non-structural proteins (NS4) both in free form and as part of immune complexes are determined in an enzyme immunoassay, washed in parallel with a buffer solution and 6M urea solution, then the avidity of these antibodies is determined and the acute form of hepatitis C is differentiated by an increase in antibody level by ≥12%, and the chronic form by their decrease in the range of 50-90%.
RU2002114254/14A 2002-05-30 2002-05-30 Method for differential diagnostics of viral hepatitis c RU2226694C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2002114254/14A RU2226694C2 (en) 2002-05-30 2002-05-30 Method for differential diagnostics of viral hepatitis c

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2002114254/14A RU2226694C2 (en) 2002-05-30 2002-05-30 Method for differential diagnostics of viral hepatitis c

Publications (2)

Publication Number Publication Date
RU2002114254A true RU2002114254A (en) 2004-01-20
RU2226694C2 RU2226694C2 (en) 2004-04-10

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2002114254/14A RU2226694C2 (en) 2002-05-30 2002-05-30 Method for differential diagnostics of viral hepatitis c

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RU (1) RU2226694C2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2479847C2 (en) * 2011-05-23 2013-04-20 Федеральное государственное учреждение научно-исследовательский институт детских инфекций Федерального медико-биологического агентства Diagnostic technique for acute viral hepatitis a in children
RU2596794C1 (en) * 2015-08-03 2016-09-10 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт детских инфекций" Федерального медико-биологического агентства Method of determining avidity of immunoglobulin g to herpes virus type 6
RU2680408C1 (en) * 2018-03-19 2019-02-21 Федеральное государственное бюджетное образовательное учреждение высшего образования "Самарский государственный медицинский университет" Министерства здравоохранения Российской Федерации Method for determining the influence of low-molecular biologically active substances on the affinite of protein-ligand bonding

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Publication number Publication date
RU2226694C2 (en) 2004-04-10

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Effective date: 20040531