RU2001130452A

RU2001130452A - Cyclic Protein Tyrosine Kinase Inhibitors

Info

Publication number: RU2001130452A
Application number: RU2001130452/04A
Authority: RU
Inventors: Джагабандху Дас; Рамеш Падманабха; Пинг Чен; Дерек Дж. Норрис; Артур М. П. ДОВЕЙКО; Джоэл С. БЭРРИШ; Джон ВИТЯК
Original assignee: Бристол-Маерс Сквибб Ко.
Priority date: 1999-04-15
Filing date: 2000-04-12
Publication date: 2003-09-27

Claims

1. The cyclic compound of formula I or its salt:

where Q is:

(1) 5 membered heteroaryl ring;

(2) 6 membered heteroaryl ring; or

(3) aryl cycle;

optionally substituted with one or more R ₁ groups;

Z is:

(1) simple communication;

(2) -R ₁₅ C = CH-; or

(3) - (CH ₂ ) _m -, where m is 1-2;

X ₁ and X ₂ each represents hydrogen or together form = O or = S;

R ₁ means:

(1) hydrogen or R ₆ ,

where R ₆ is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, arylalkyl, heterocyclo or heterocycloalkyl, each of which is unsubstituted or substituted by Z ₁ , Z ₂ and one or more (preferably one or two) groups Z ₃ .

(2) —OH or —OR ₆ ;

(3) —SH or —SR ₆ ;

(4) —C (O) ₂ H, —C (O) _q R ₆ , or —OC (O) _q R ₆ , where q is 1 or 2;

(5) -SO ₃ H or -S (O) _q R ₆ ;

(6) halogen (halogen);

(7) cyano;

(8) nitro;

(9) -Z ₄ -NR ₇ R ₈ ;

(10) -Z ₄ -N (R ₉ ) -Z ₅ -NR ₁₀ R ₁₁ ;

(11) -Z ₄ -N (R ₁₂ ) -Z ₅ -R ₆ ;

(12) -P (O) (OR ₆ ) ₂ ;

R ₂ and R ₃ each independently represents

(1) hydrogen or R ₆ ,

(2) -Z ₄ -R ₆ ; or

(3) -Z ₁₃ -NR ₇ R ₈ ;

R ₄ and R ₅ :

(1) each independently, is hydrogen or R ₆ ;

(2) -Z ₄ -N (R ₉ ) -Z ₅ -NR ₁₀ R ₁₁ ;

(3) -N (R ₉ ) Z ₄ R ₆ ; or

(4) together with the nitrogen atom to which they are attached, form a 3-8 membered saturated or unsaturated heterocycle unsubstituted or substituted with substituents Z ₁ , Z ₂ and Z ₃ , and this heterocycle may, if necessary, be condensed with benzene a ring, which, in turn, is unsubstituted or has substituents Z ₁ , Z ₂ and Z ₃ ;

R ₇ , R ₈ , R ₉ , R ₁₀ , R ₁₁ and R ₁₂ :

(1) each independently, is hydrogen or R ₆ ;

(2) R ₇ and R ₈ may together be alkylene, alkenylene, or heteroalkyl forming a 3-8 membered saturated or unsaturated ring to the nitrogen atom to which they are bonded, the ring being unsubstituted or substituted with substituents Z ₁ , Z ₂ and Z ₃ ; or

(3) any two of R ₉ , R ₁₀ and R ₁₁ may together be alkylene or alkenylene forming a 3-8 membered saturated or unsaturated ring together with the nitrogen atoms to which they are attached, this ring being unsubstituted or substituted with substituents Z ₁ , Z ₂ and Z ₃ ;

R ₁₃ means:

(1) cyano;

(2) nitro;

(3) -NH ₂ ;

(4) -NHOalkyl;

(5) —OH;

(6) -NHOaryl;

(7) -MHCOOalkyl;

(8) -NHCOOaryl;

(9) -NHSO ₂ alkyl;

(10) -NHSO ₂ aryl;

(11) aryl;

(12) heteroaryl;

(13) -Oalkyl; or

(14) -Oaryl;

R ₁₄ means:

(1) -NO ₂ ;

(2) -COOalkyl; or

(3) -COOaryl;

R ₁₅ means:

(1) hydrogen;

(2) alkyl;

(3) aryl;

(4) arylalkyl; or

(5) cycloalkyl;

Z ₁ , Z ₂ and Z ₃ each independently means:

(1) hydrogen or Z ₆ , where Z ₆ is (i) alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, alkylaryl, cycloalkyl, heterocyclo or heterocycloaryl; (ii) a group (i) which itself has as substituents or more the same or different groups (i); or (iii) a group (i) or (ii) which has one or more of the following groups as substituents, (2) to (16) denoting Z ₁ , Z ₂ and Z ₃ ;

(2) —OH or —OZ ₆ ;

(3) —SH or —SZ ₆ ;

(4) -C (O) _q H, -C (O) _q Z ₆ or -OC (O) _q Z ₆ ;

(5) -SO ₃ H, -S (O) _q Z ₆ ; or -S (O) _q N (Z ₉ ) Z ₆ ;

(6) halogen (halogen);

(7) cyano;

(8) nitro;

(9) -Z ₄ -NZ ₇ Z ₈ ;

(10) -Z ₄ -N (Z ₉ ) -Z ₅ -NZ ₇ Z ₈ ;

(11) -Z ₄ -N (Z ₁₀ ) -Z ₅ -Z ₆ ;

(12) -Z ₄ -N (Z ₁₀ ) -Z ₅ -H;

(13) oxo;

(14) —OC (O) —Z ₆ ;

(15) any two of Z ₁ , Z ₂ and Z ₃ may together mean alkylene or alkenylene, which forms, together with the nitrogen atoms to which they are attached, a saturated or unsaturated ring; or

(16) any two of Z ₁ , Z ₂ and Z ₃ can together denote -O- (CH ₂ ) _r -O, where r is 1-5, forming a 4-8 membered ring together with the atoms to which they are bonded ;

Z ₄ and Z ₅ each independently means:

(1) simple communication;

(2) -Z ₁₁ -S (O) _q -Z ₁₂ -;

(3) -Z ₁₁ -C (O) -Z ₁₂ -;

(4) -Z ₁₁ -C (S) -Z ₁₂ -;

(5) -Z ₁₁ -OZ ₁₂ -;

(6) -Z ₁₁ -SZ ₁₂ -;

(7) -Z ₁₁ -OC (O) -Z ₁₂ -; or

(8) -Z ₁₁ -C (O) -OZ ₁₂ -;

Z ₇ , Z ₈ , Z ₉ and Z ₁₀ :

(1) each independently, is hydrogen or Z ₆ ;

(2) Z ₇ and Z ₈ or Z ₆ and Z ₁₀ can together mean alkylene or alkenylene forming a 3-8 membered saturated or unsaturated ring together with the atoms to which they are bonded, this ring being unsubstituted or substituted with Z substituents ₁ , Z ₂ and Z ₃ ; or

(3) Z ₇ or Z ₈ together with Z ₉ can denote alkylene or alkenylene forming a 3-8 membered saturated or unsaturated ring together with the nitrogen atoms to which they are bonded, this ring being unsubstituted or substituted with Z ₁ substituents, Z ₂ and Z ₃ ;

Z ₁₁ and Z ₁₂ each independently means:

(1) simple communication;

(2) alkylene;

(3) alkenylene; or

(4) alkynylene; and

Z ₁₃ means:

(1) simple communication;

(2) -Z ₁₁ -S (O) _q -Z ₁₂ -;

(3) -Z ₁₁ -C (O) -Z ₁₂ -;

(4) -Z ₁₁ -C (S) -Z ₁₂ -;

(5) -Z ₁₁ -OZ ₁₂ -;

(6) -Z ₁₁ -SZ ₁₂ -;

(7) -Z ₁₁ -OC (O) -Z ₁₂ -;

(8) -Z ₁₁ -C (O) -OZ ₁₂ -;

(9) -C (NR ₁₃ ) -;

(10) —C (CHR ₁₄ ) -; or

(11) -C (C (R ₁₄ ) ₂ ) -.

provided that the specified connection is not

(a) a compound of formula (i):

where R _1a is alkyl or —C (O) NHNH ₂ ;

R _2a and R _3a are independently hydrogen, alkyl, —C (O) alk;

and

R _4a is hydrogen, and R _5a is aryl, alkyl substituted aryl, halo substituted aryl, aralkyl, cycloalkyl or amino;

or

R _4a is alkyl, and R _5a is alkyl or aryl;

or

R _4a and R _5a together with the nitrogen atom bound to them form a morpholine cycle;

(b) a compound of formula (ii) or (iii):

where X is oxygen or sulfur;

R _1b is hydrogen, halogen, alkyl or haloalkyl;

R _2b is hydrogen, alkyl, aryl, aralkyl, heterocycle, heterocycloalkyl;

R _3b is alkyl, aryl, aralkyl, heterocycle, heterocycloalkyl;

R _4b is hydrogen, alkyl or aralkyl; and

R _5b is hydrogen, alkyl, aryl, aralkyl, heterocycle or heterocycloalkyl;

(c) a compound of formula (iv):

where R _4d and R _{5d are} independently hydrogen, alkyl, alkenyl or phenyl;

R ₂₇ is hydrogen or alkyl;

(d) a compound of formula (v):

where R _3e is phenyl, pyridyl or pyrimidinyl, optionally with a substituent, halogen or alkyl;

R ₅₀ and R ₅₁ each independently represents hydrogen, halogen or alkyl;

R ₅₂ and R ₅₃ each independently represents hydrogen, halogen, alkyl or haloalkyl;

R ₅₄ and R ₅₆ , each independently, are hydrogen, halogen, alkyl, nitro or amino;

R ₅₅ is hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio or alkoxycarbonyl; and

n is zero or 1.

(e) a compound of formula (vi):

where R _2f and R _3f independently represent hydrogen or alkyl;

R _4f is hydrogen or alkyl; and

R _5f is alkyl, cycloalkyl, aryl, alkyl substituted aryl, haloalkyl substituted aryl, halogen substituted aryl, alkoxy substituted aryl, nitro substituted aryl, aryl substituted aryl, aralkyl or heteroaryl;

or

R _4f and R _5f together with the nitrogen atom bound to it form a morpholine cycle;

(f) a compound of formula (vii):

where R _2g represents H or —N = O;

R _3g is H or alkyl;

R _4g is H or alkyl; and

R _5g is alkyl, aryl or aralkyl.

(g) a compound of formula (viii):

where R _1h is alkyl or haloalkyl; and

R ₅₇ is alkyl, alkoxy, alkenyl, alkenoxy, alkynyl, alkynyloxy, cycloalkyl, cycloalkenyl, cycloalkoxy, cycloalkenyloxy or phenyl;

(h) a compound of formula (ix):

where R _2i is hydrogen or alkyl;

R _3i is —C (O) —NH— (alk); and

R ₅₈ and R ₅₉ independently represent hydrogen, alkyl or halogen.

(i) a compound of formula (x):

where R _5j is alkynyl; and

R ₆₁ and R _{62 are} independently alkoxy or haloalkoxy.

(j) a compound of formula (xi):

where R _1k is hydrogen, alkyl, aryl or aralkyl;

* R _1k is alkyl, aryl or aralkyl;

R _3k and R _{5k are} independently alkyl, aryl or aralkyl;

(k) a compound of formula (xii):

where R _2m is hydrogen or alkyl; and

R _3m is the radical of an anthraquinone, phthalocyanine, formazan, nitroaryl, dioxazine, phenazine or stilbene dye;

(1) a compound of the formula (xiii):

where R _1n is aralkyl or - (alk) C (O) - (aryl);

R _2n is hydrogen, alkyl alkenyl, hydroxyalkyl, and

R _3n is aralkyl;

(m) a compound of formula (xiv):

where R _2p and R _3p independently represent hydrogen, alkyl, alkenyl. alkoxy, -CHO, -C (O) - (alk), -COO- (alk), - (alkyl) -COO- (alk), alkylthioalkyl or aryl; and

R _5p is substituted, optionally phenyl;

(n) a compound of the formula (xv), (xvi) or (xvii):

where X is oxygen or sulfur;

R _2q is hydrogen;

R _3q represents optionally, but not necessarily substituted phenyl;

R _4q is hydrogen;

R _5q is substituted, optionally phenyl;

R _2r and R _3r each independently are hydrogen, alkyl or aralkyl;

R _4r is hydrogen; and

R _5r is substituted, optionally phenyl;

(o) a compound of the formula (xviii):

where X is oxygen or sulfur;

R _2s is hydrogen;

R _3s is substituted, optionally phenyl;

R _4s is hydrogen; and

R _5s is substituted, optionally phenyl;

(p) a compound of the formula:

or

(q) a compound of the formula:

or

or

(r) a compound of the formula:

2. The compound according to claim 1, characterized in that the said compound is not a compound of the formula (xxi)

where R _2aa is hydrogen or alkyl;

R _3aa is cycloalkyl, aryl, heterocyclo or heteroaryl;

R _4aa is aryl or heteroaryl; and

R _5aa is hydrogen, alkyl, alkenyl, haloalkyl, haloalkenyl, aryl, heteroaryl, aralkyl or heteroaralkyl;

3. The compound according to claim 1, characterized in that the said compound is not a compound of the formula (xxii)

where R _1ab is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, carboxy, alkoxycarbonyl or aralkoxycarbonyl;

R _2ab is hydrogen, alkyl, cycloalkyl or heteroaryl;

R _3ab is hydrogen, alkyl, cycloalkyl, heteroaryl or —C (O) —N (R ₆₄ ) - (CH ₂ ) _n —R ₆₅ ; with the proviso that R _2ab and R _3ab are not both hydrogen;

R _4ab is hydrogen, alkyl or cycloalkyl;

R _5ab represents a group of the formula:

where A is carbonyl or sulfonyl;

B is hydrogen, alkyl or cycloalkyl;

R ₆₃ is aryl, aralkyl, heterocycle, heterocycloalkyl, hydroxy, hydrogen or alkyl;

or R ₆₃ is carboxy, carboxyalkyl, alkyl-O-CO-, aralkyl-O-CO-,

alkyl-CO-, aralkyl-CO-, heteroalkyl-CO-, alkylsulfonyl, arylsulfonyl or heteroarylsulfonyl and k is zero;

or R ₆₃ is an alpha amino acid linked through an amino group and 1 is zero and k is 1;

d, f, g, k, 1 and m are each independently zero or 1, while m is not zero when f or g is 1;

i is zero or 1, while k and 1 are also zero when i is zero;

e is 0-3;

h is 0-5;

j is 0-2; and

the sum of e, h and j is 2-7;

R ₆₄ is hydrogen, alkyl, cycloalkyl or heteroaryl;

R ₆₅ is hydrogen, alkyl, cycloalkyl, aryl or heteroaryl;

n is an integer from 0 to 4;

4. The compound according to claim 1, characterized in that said compound is not a compound of formula (xxiii):

where R ₆₆ denotes a heterocycle.

5. The compound according to claim 1, characterized in that the said compound is not a compound of the formula (xxiv) or (xxv):

or

6. The compound according to claim 1, characterized in that said compound is not

(a) a compound of the formula (xxvi):

where D, E, F, G, and J are selected from carbon and nitrogen so that a heteroaryl cycle known in the art is formed;

R _2ba is hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclo, sulfonyl, trihalomethanesulfonyl, hydroxy, alkoxy and carboxy;

Z is oxygen or sulfur;

And selected from oxygen, nitrogen and sulfur;

B is selected from nitrogen and sulfur;

R _4ba and R _5ba are independently hydrogen, alkyl, cycloalkyl, aryl, carbonyl, carboxy, sulfonyl, trihalomethanesulfonyl,

or R _4ba and R _5ba together form a five- or six-membered heterocyclic ring;

wherein the heteroaryl ring containing A and B is optionally substituted.

(b) a compound of the formula (xxvii):

where R _2bb is hydrogen or alkyl or cycloalkyl;

R _3bb is optionally substituted phenyl;

R _4bb is hydrogen or alkyl; and

R _5bb is substituted, optionally phenyl or pyridyl;

(c) a compound of the formula (xxviii):

where R _2bc is hydrogen, alkyl or cycloalkyl;

R _3bc is hydrogen, alkyl, aryl or aralkyl;

or R _2bc and R _3bc together form a heterocyclic ring;

R _4bc is hydrogen or alkyl; and

R _5bc is aryl;

(d) a compound of the formula (xxix):

where R _1bd is alkyl, carboxy, hydroxyalkyl, haloalkyl, alkylthio, hydroxyiminoalkyl or alkenyl;

R _2bd and R _3bd independently represent hydrogen, alkyl, pyridyl, acyl, aryl, aralkyl or guanidino; and

R _4bd and R _5bd together form an unsaturated heterocyclic ring;

(e) a compound wherein R ₃ is alkyl, alkenyl, alkynyl, cycloalkylalkyl, cycloalkenylalkyl or aralkyl when

(a) Q is pyridine, thiophene, furan, pyrrole, pyrazole, thiazole or isothiazole and

(b) R ₂ is hydrogen or alkyl;

(f) a compound of formula (xxx):

where R _1be is aralkyl;

(g) a compound in which R ₃ denotes a group of the formula:

where Z is nitrogen or carbon; and

R * and R ** independently represent hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, araloxy, alkoxyalkyl, cycloalkyl, alkenyl, alkenyloxy, alkynyl, alkynyloxy, alkylthioalkyl or amino; or

(h) a compound in which either R ₂ or R ₃ is heteroaryl.

7. The compound according to claim 1, characterized in that Z is a bond, and X ₁ and X ₂ together form = O or = S.

8. The compound according to claim 7, wherein R ₁ is hydrogen, halogen, alkyl, aryl, alkoxy, alkoxycarbonyl or aryloxycarbonyl.

9. The compound of claim 8, wherein R ₁ is hydrogen.

10. The compound according to claim 7, characterized in that R ₂ denotes hydrogen.

11. The compound according to claim 7, characterized in that R ₃ denotes -Z ₄ -R ₆ or -Z ₁₃ -NR ₇ R ₈ .

12. The compound according to claim 7, characterized in that R _{2 is} not heteroaryl, and R ₃ is aryl which is unsubstituted or has substituents Z ₁ , Z ₂ and one or more Z ₃ groups.

13. The compound according to claim 7, characterized in that R ₄ denotes hydrogen.

14. The compound according to claim 7, characterized in that R ₅ denotes an aryl group having substituents Z ₁ , Z ₂ and one or more Z ₃ groups.

15. The compound according to claim 7, characterized in that O denotes thiazole.

16. The compound of claim 15, wherein R ₃ is —Z ₄ R ₆ , where Z ₄ is a single bond and R ₆ is aryl or heteroaryl, which is unsubstituted or has substituents Z ₁ , Z ₂ and one or more groups Z ₃ .

17. The compound according to clause 16, wherein R ₆ denotes aryl having as a substituent at least one group Z ₃ where Z ₃ denotes -Z ₁₃ -NZ ₇ Z ₈ where Z ₄ denotes a bond z ₇ is hydrogen or alkyl; and Z ₈ is heterocyclic substituted alkyl.

18. The compound according to claim 17, wherein R ₁ is hydrogen or alkyl, R ₂ and R _{4 are} independently hydrogen or alkyl, and R ₅ is aryl which is unsubstituted or has substituents Z ₁ , Z ₂ and one or more groups Z ₃ .

19. The compound according to clause 16, wherein R ₆ denotes a heteroaryl having as a substituent at least one group Z ₃ where Z ₃ denotes -Z ₄ -NZ ₇ Z ₈ where Z ₄ denotes a bond, Z ₇ is hydrogen or alkyl; and Z ₈ is heterocyclic substituted alkyl.

20. The compound according to clause 16, wherein R ₆ is heteroaryl having, as a substituent, at least one Z ₃ group, where Z ₃ is alkyl.

21. The compound according to claim 20, wherein R ₁ is hydrogen or alkyl, R ₂ and R _{4 are} independently hydrogen or alkyl, and R ₅ is aryl, unsubstituted or with substituents Z ₁ , Z ₂ and one or more groups Z ₃ .

22. The compound according to claim 1, characterized in that it is selected from the group consisting of:

[5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -4-trifluoromethyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

2-amino-N- (2,4,6-trimethylphenyl) -4-trifluoromethyl-5-thiazolecarboxamide, trifluoroacetate (1: 1),

[5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -4-phenyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

2-amino-N- (2,4,6-trimethylphenyl) -4-phenyl-5-thiazolecarboxamide, trifluoroacetate (1: 1),

[5 - [[phenylamino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,4-Dichlorophenyl] amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester

[5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2-Methoxy-6-methylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-methyl-5 - [[[3-methyl-4- (1-methylethyl) phenyl] amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [[[2-methyl-6- (1-methylethyl) phenyl] amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,4-Dimethylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [[(2-methylphenyl) amino] carbonyl] -2-thiazolyl] -carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2-Chloro-6-methylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[[2- (1,1-Dimethylethyl) -4-methylphenyl] amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2-Furanylmethyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[[3-methoxy-5- (trifluoromethyl) phenyl] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(4-cyclohexylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(cyclohexylmethyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,3-Dihydro-1H-indenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [(2,5-Dihydro-1H-pyrrol-1-yl) carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [(2,5-Dihydro-2,5-dimethyl-1H-pyrrol-1-yl) carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

1 - [[2 - [[(1,1-dimethylethoxy) carbonyl] amino-4-methyl-5-thiazolyl] carbonyl-L-prolinamide,

[5 - [(4-Formyl-1-piperazinyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5- (1,4-dioxa-8-azaspiro [4.5] decan-8-ylcarbonyl) -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[3 - [(dimethylamino) carbonyl] -1-piperidinyl] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [(octahydro-1-quinolinyl) carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

2 - [[(1,1-dimethylethoxy) carbonyl] amino] -4-methyl-5-thiazolecarboxylic acid-2 - [(1,1-dimethylethoxy) carbonyl] hydrazide,

[5 - [[(4-methoxyphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [[(4-methylphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(1,2-dimethylpropyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,2-Dimethylpropyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [(2-propynylamino) carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [(methylphenylamino) carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [[((3,4,5-trimethoxyphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ether, 1,1-dimethylethyl ether [5 - [[(2, 6-bis (1-methylethyl) phenyl] amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid,

[5 - [[[3- (1H-imidazol-1-yl] propyl] amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[((3,4-difluorophenyl) methyl] amino] -carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

N - [[2 - [[(1,1-dimethylethoxy) carbonyl] amino] -4-methyl-5-thiazolyl] carbonyl] -L-leucine methyl ester,

5 - [[[2 - [[(1,1-Dimethylethoxy) carbonyl] amino] -4-methyl-5-thiazolyl] carbonyl] amino] -4-oxopentanoic acid methyl ester,

[5 - [[[2- (ethylthio) ethyl] amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

1,1-Dimethylethyl ether [5 - [[bis (3-methylbutyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid,

[5 - [[Ethyl (1-methylethyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester

2 - [[(1,1-dimethylethoxy) carbonyl] amino] -4-methyl-5-thiazolecarboxylic acid 2 - [[(3,5-dichlorophenyl) amino] thiooxomethyl] hydrazide

[5 - [[bis (2-ethoxyethyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [[(3 - [(trifluoroacetyl) amino] -1-pyrrolidinyl] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,6-dimethylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

2 - [[(2,2-Dichloro-1-methylcyclopropyl) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(Cyclohexylacetyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazole-carboxamide,

2 - [(2,5-Difluorobenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazole-carboxamide,

2 - [(5-Bromo-2-chlorobenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(3-Cyanobenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[4- (Acetylamino) benzoyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[3- (trifluoromethyl) benzoyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[2- (2-phenylethyl) benzoyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(3,5-Dimethylbenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Ethenylbenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Butylbenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(4-pentylbenzoyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(2-methyl-1-oxohexyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(2-Chloro-6-fluorophenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(2-methylphenyl) acetyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(3-Methoxyphenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(3,4-Dimethoxyphenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(4-Chlorophenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [([1,1Biphenyl) -4-ylacetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(1-oxo-4-phenylbutyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(2-Hydroxy-2-phenyl-1-oxopropyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(2-Hydroxy-1-oxohexyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[1-oxo-4- (2-thienide) -butyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(3-thienylcarbonyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(2-Benzofuranylcarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

N- [4-Methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -4-pyridinecarboxamide, N-oxide,

6-Chloro-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -3-pyridinecarboxamide,

N- [4-Methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -3-pyridinecarboxamide,

N- [4-Methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -3-quinolinecarboxamide,

4-Methyl-2 - [[(4-nitrophenyl) acetyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(2,4,6-trichlorobenzoyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[2 - [[3- (trifluoromethyl) phenyl] amino] benzoyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[4- (4-nitrophenyl) -1-oxobutyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[4- (methylsulfonyl) benzoyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Heptylbenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(2-Difluorophenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

(S) -2 - [[2- (Dipropylamino) -1-oxopropyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(2-Biphenylenecarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[3- (3-Methoxyphenyl) -1-oxopropyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-N- (2,4,6-trimethylphenyl) - [[(2,4,6-trimethylphenyl) acetyl] amino] -5-thiazolecarboxamide,

4-Methyl-2 - [(1-oxo-6-heptenyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(1,3-Benzodioxol-5-yl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[2- (phenylmethoxy) phenyl] acetyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(3-phenoxyphenyl) acetyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(3,5-Dimethoxyphenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[4- [4- [Bis (2-chloroethyl) amino] phenyl-1-oxobutyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4 - [[4 - [[[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] phenyl] amino] -4-oxobutane methyl ester acids

4-Methyl-2 - [[(phenylsulfonyl) acetyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[2- (Acetylamino) -1-oxohexyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[4 - [(Dipropylamino) sulfonyl] benzoyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Cyclohexylbenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Bromo-3-methylbenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(2,3-Difluorophenyl) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[4- (1-methylethyl) phenyl] acetyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[4- (1,1-Dimethylethyl) cyclohexyl] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

N, N-Dimethyl-N '- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] butanediamide,

2 - [(Benzo [b] thiophen-2-ylcarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(1-Adamantylcarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(4-methylcyclohexyl) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(1,7-dioxooctyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[2- (Acetylamino) -4- (ethylthio) -1-oxobutyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

1,5-Dimethyl-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -1H-pyrazole-3-carboxamide,

2 - [[[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] benzoic acid,

N- [4-Methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -6-benzothiazolecarboxamide,

1-Ethyl-4-methyl-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -1H-pyrazole-3-carboxamide,

4-Methyl-2 - [[3 - [(3H-1,2,3-triazolo [4,5-b] pyridin-3-yloxy) methyl] benzoyl] amino] -N- (2,4,6- trimethylphenyl) -5-thiazolecarboxamide,

2 - [(2-Furanylcarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Chlorobenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(2,2-Dimethyl-1-oxopropyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

[4-methyl-5 - [[(2-nitrophenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl-5 - [[(2,4,6-trimethylphenyl) amino] -carbonyl] -2-thiazolyl] carbamic acid phenylethyl ester,

Methyl- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-Methyl (2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid methyl ester,

[4-Ethyl-5 - [[((2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

[5 - [[(2,6-Dichlorophenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid 1,1-dimethylethyl ester,

2-amino-N- (2-methyl-6-isopropylphenyl) -4-methyl-5-thiazolecarboxamide, trifluoroacetate (1: 1),

2- (Benzoylamino) -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(phenylacetyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Acetylamino) acetyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -6-thiazolecarboxamide,

2-amino-4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarbothioamide,

2 - [(4-Bromobenzolyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(4-nitrobenzolyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Cyanobenzoyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(5-nitro-2-furanyl) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [(2-thienylcarbonyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

Methyl ethyl 4 - [[[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] benzoic acid,

2 - [(5-Isoxazolylcarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(3-Furanylcarbonyl) amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(2,4-Dimethyl-5-thiazolyl) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [(4-Methoxy-3-thienyl) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(5-nitro-3-thienyl) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[4 - [(4-Chlorophenyl) thio] -3-thienyl] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(5-Chloro-4-methoxy-3-thienyl) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[2 - [(4,5-Dihydro-4,4-dimethyl-2-oxazolyl) -3-thienyl] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(2-Acetyl-3-thienyl) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(methylamino) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(phenylamino) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(4-methylphenyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(phenylmethyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Cyclohexylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2-Chlorophenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(3-Fluorophenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2,6-Dimethylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

[5 - [[(2,4,6-Trimethylphenyl) amino] carbonyl] -4-methyl-2-thiazolyl] carbamic acid phenyl ester,

4-Methyl-2 - [[[(2-phenylethyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Hexylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(1,1-Dimethylethyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(3-Fluoro-4-methylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Methoxyphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Diethylamino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[Bis (1-methylethyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[methyl (phenylmethyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(methylphenylamino) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Cyclohexylmethylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(1-phenylethyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(Cyclopropylmethyl) propylamino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(2-methylcyclohexyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(Cyclohexylmethyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2,3-Dihydro-1H-inden-1-yl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(1-naphthalenylmethyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[Bis (phenylmethyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2,6-Dimethyl-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -4-morpholinecarboxamide,

2-Ethyl-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -1-piperidinecarboxamide

1 - [[[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] -3-piperidinecarboxylic acid ethyl ester,

3,3-Dimethyl-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -4-piperidinecarboxamide,

1 - [[[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] -4-piperidinecarboxylic acid ethyl ester,

4-Methyl-2 - [[[(3-methyl-2-pyridinyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[1- (phenylmethyl) -4-piperidinyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

Octahydro-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -1 (2H) -quinolinecarboxamide,

3,4-Dihydro-N- [4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] -2 (1H) -isoquinolinecarboxamide,

2 - [[[(1,5-dimethylhexyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[1- (methylheptyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(2-Fluorophenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[((2-Methoxyphenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(2-Ethoxyphenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(3-Methoxyphenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(4-Chlorophenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[((4-Methoxyphenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2,2-Diphenylethyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2-aminoethyl) phenylamino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (3-Methoxyphenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (3,4-Dimethoxyphenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (4-Methoxyphenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(3-phenylpropyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (Cyclohex-1-en-1-yl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[4- (1,1-Dimethylethyl) cyclohexyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(3-Butoxypropyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (2-Methoxyphenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(2-Chloro-4-fluorophenyl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Hexylmethylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[1- (4-Chlorophenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (3-Chlorophenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2- (2-thienyl) ethyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (2-Fluorophenyl) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2- (2-pyridynyloxy) ethyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(2-Bromo-4,5-dimethoxyphenyl) methyl] methylamino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

(E) -2 - [[[(3,7-Dimethyl-2,6-octadienyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[(2,3-Dihydro-1,4-benzodioxin-2-yl) methyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5 thiazole carboxamide,

2 - [[[[3-Methoxy-5- (trifluoromethyl) phenyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Cyclohexylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(5,6,7,8-tetrahydro-1-naphthalenyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(1-Anthracenylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Chloro-1-naphthalenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(2-naphthalenylamino) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(1H-Indol-5-ylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(1,3-Benzodioxol-5-ylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(2-pyrazinylamino) carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(5-Chloro-2-pyridinyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(6-methyl-2-pyridinyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(2-methyl-4-quinolinyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2,3-dihydro-1,4-benzodioxin-6-yl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[([1,1'-Biphenyl] -2-ylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Methoxy-2-methylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-N- (2,4,6-trimethylphenyl) -2 - [[[(2,4,6-trimethylphenyl) amino] -carbonyl] amino] -5-thiazolecarboxamide,

2 - [[[[2- (2-Hydroxyethyl) phenyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(3-Methoxyphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Methoxy [1,1'-biphenyl] -3-yl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide

2 - [[[(3-Acetylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(3-Cyanophenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[4-Fluoro-2- (trifluoromethyl) phenyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Hexyloxyphenyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4 - [[[[4-methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] amino] benzoic acid ethyl ester,

2 - [[[(4-Decylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(4-propylphenyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(3,4,5-trimethoxyphenyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[4 - [[(5-methyl-3-isoxazolyl) amino] sulfonyl] phenyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) thiazole carboxamide ,

4 - [[[[4-methyl-5 - [[((2,4,6-trimethylphenyl) amino] carbonyl] -2-thiazolyl] amino] carbonyl] amino] benzoic acid butyl ester,

2 - [[(1-Isoquinolinylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2 - [(phenylmethyl) thio] phenyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) thiazolecarboxamide,

4-Methyl-2 - [[[[4 - [(5-phenoxypentyl) oxy] phenyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[5- (1,1-Dimethylpropyl) -2-methoxyphenyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(1,2-Dihydro-5-acenaphthalenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(3-phenoxyphenyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2- (4-morpholinyl) phenyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2- (1-piperidinyl) phenyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(1-Acetyl-2,3-dihydro-1-indol-6-yl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide ,

2 - [[[(2-Bromo-5-methoxyphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2,3-Dimethyl-1H-indol-5-yl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2 - [[(1-methylethyl) amino] carbonyl] phenyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) thiazolecarboxamide,

2 - [[[(3-Bromo-2-methylphenyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(4-Methoxybutyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(3,3-Dimethylbutyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(2-methoxybutyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[(3-methylbutyl) amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[(2-Methoxyethyl) amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[[[2- (Dimethylamino) ethyl] amino] carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[[[2- (methylio) ethyl] amino] carbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (2,3-dihydro-1H-inden-5-yl) -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N-2-naphthalenyl-4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (3-hydroxy-2-naphthalenyl) -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (2-fluoro-5methylphenyl) -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (2,6-dimethylphenyl) -4-methyl-5-thiazolecarboxamide,

N- (3-Bromo-2,4,6-trimethylphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- [2,6-dimethyl-3- (1-methylethyl) phenyl] -4-methyl-5-thiazolecarboxamide,

N- (2-Bromo-4,6-dimethylphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

3 - [[[2 - [[(butylamino) carbonyl] amino] -N-methyl-5-thiazolyl] carbonyl] amino] -4-methyl-2-thiophenecarboxylic acid methyl ester,

2 - [[(Butylamino) carbonyl] amino] -4-methyl-N- (2-methyl-6-quinolinyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- [2,6-dimethoxyphenyl) -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (4-methoxy-2-naphthalenyl) -4-methyl-5-thiazolecarboxamide

2 - [[(Butylamino) carbonyl] amino] -N- (2-methyl-1-naphthalenyl) -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- [4- (dimethylamino) -2,3,5,6-tetramethylphenyl] -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (6-methyl-5-quinolinyl) -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- [2- (2-hydroxyethyl) -6-methylphenyl] -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (2,6-dimethyl-3-nitrophenyl) -4-methyl-5-thiazolecarboxamide,

N- (2-Bromo-3,4,6-trimethylphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

N- (2-Acetyl-6-hydroxyphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

[4 - [[[2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolyl] carbonyl] amino] -2,3,5,6-tetramethylphenyl] carbamic acid 1,1-dimethylethyl ester,

2 - [[(Butylamino) carbonyl] amino] -N- (2,6-dichlorophenyl) -4-methyl-5-thiazolecarboxamide,

N- (4-amino-2,3,5,6-tetramethylphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

N- [5- (Acetylamino-2,4-dimethylphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

N- (4-Bromo-2,6-dimethylphenyl) -2 - [[(butylamino) carbonyl] amino] -4-methyl-5-thiazolecarboxamide,

2 - [[(Butylamino) carbonyl] amino] -N- (2-chloro-6-methylphenyl) -4-methyl-5-thiazolecarboxamide,

4-Methyl-2 - [(methylsulfonyl) amino] -N-2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

4-Methyl-2 - [[(phenylamino) thiocarbonyl] amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 - [[(Ethylamino) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide

N- (2-Chloro-6-methylphenyl) -2 - [(cyclopropylcarbonyl) amino] -5-thiazolecarboxamide,

2 - [[[(1,1-Dimethylethyl) amino] carbonyl] amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

2 - [[(1,1-Dimethylethoxy) carbonyl] amino] -4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazole acetamide,

2-amino-4-methyl-N- (2,4,6-trimethylphenyl) -5-thiazole acetamide,

N- (2-Chloro-6-methylphenyl) -2 - [(4,6-dimethyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(4-ethyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2,6-dimethyl-4-pyrimidinyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2- (3-pyridazinylamino) -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -4-methyl-2 - [(2-thienylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(cyclopropylcarbonyl) amino] -4-methyl-5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -4-methyl-2 - [(2-furanylcarbonyl) amino] -5-thiazolecarboxamide

N- (2-Chloro-6-methylphenyl) -4-methyl-2 - [(3-thienylcarbonyl) amino] -5-thiazolecarboxamide

N- (2-Chloro-6-methylphenyl) -4-methyl-2 - [(3-furanylcarbonyl) amino] -5-thiazolecarboxamide

trans-N- (2-Chloro-6-methylphenyl) -4-methyl-2 - [[(2-phenylcyclo-propyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -4-methyl-2 - [[(2-methylcyclo-propyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-cyclobutylcarbonyl) amino] -4-methyl-5-thiazolecarboxamide

N- (2-Chloro-6-methylphenyl) -2 - [(2-cyclopentylcarbonyl) amino] -4-methyl-5-thiazolecarboxamide,

2- (Benzoylamino) -N- (2-chloro-6-methylphenyl) -4-methyl-5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(1-oxopropyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(1-oxobutyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-ethyl-1-oxobutyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[(1-phenylcyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[(1-methylcyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[(2,2-dichloro-1-methylcyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[(2-methylcyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-chloro-6-methylphenyl) -2 - [[(1-hydroxycyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-chloro-6-methylphenyl) -2 - [[(2,2,3,3-tetramethylcyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[(1-cyanocyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(cyclobutylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(cyclopentylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(cyclohexylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(phenylacetyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(cyclohexylacetyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(pyridinylacetyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[(2,5-dimethyl-1N-pyrrol-3-yl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-pyridylincarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(3-pyridinylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(4-pyridinylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(3-thienylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-thienylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-furanylcarbonyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(3-furanylcarbonyl) amino] -5-thiazolecarboxamide,

trans-N- (2-Chloro-6-methylphenyl) -2 - [[(2-phenylcyclopropyl) carbonyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-methyl-1-oxopentyl) amino] -5-thiazolecarboxamide,

2- (Benzoylamino) -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

2 - [(Cyclopropylcarbonyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

2 - [(Cyclopropylcarbonyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

N- (2-Chloro-4,6-dimethylphenyl) -2 - [(cyclopropylcarbonyl) amino] -5-thiazolecarboxamide,

1,1 (4- [2-oxo-2 - [(2,4,6-trimethylphenyl) amino] ethyl] -2-thiazolyl] carbamic acid dimethylethyl ester

2-amino-N- (2,4,6-trimethylphenyl) -4-thiazoleacetamide,

2-Methyl-5-nitro-N- (2,4,6-trimethylphenyl) benzamide,

5-amino-2-methyl-N- (2,4,6-trimethylphenyl) benzamide,

2-amino-5-chloro-N- (2,4,6-trimethylphenyl) -4-pyrimidinecarboxamide,

1,1 [4-Methyl-5 - [[(2,4,6-trimethylphenyl) amino] carbonyl] -2-oxazolyl] carbamic acid dimethylethyl ester,

2-amino-4- (methyl) -N- (2,4,6-trimethylphenyl) -5-oxazolecarboxamide, trifluoroacetate (1: 1),

2-amino-N- (2,4,6-trimethylphenyl) -5-pyridinecarboxamide,

3-amino-N- (2,4,6-trimethylphenyl) -4-pyridinecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(4-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

2 - [(6-amino-2-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(6-propyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N- (X-chloro-6-methylphenyl) -2 - [(6-ethyl-4-pyrimidinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (2-pyridinylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(5-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(4-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(3-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

2 '- [(5-Bromo-3-methyl-2-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

2 '- [(6-amino-2-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

2 '- [(5-Bromo-2-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3- (phenylmethoxy) -2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(5-chloro-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-ethyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-propyl-2-pyridyline) amino] -5-thiazolecarboxamide,

2 '- [(3-Bromo-5-methyl-2-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

2 '- [(2-amino-3-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

2 '- [(3-amino-2-pyridinyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (4-pyridylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (3-pyridinylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-Chloro-3-pyridyline) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(2-chloro-3-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-methoxy-3-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(3,5-dimethyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (phenylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(3-ethylphenyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(3,5-dimethylphenyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(4,6-dimethyl-2-pyrimidinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-ethyl-4-pyrimidinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(6-chloro-2-pyrazinyl) amino] -5-thiazolecarboxamide,

2 '- [(3-aminophenyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(3-hydroxyphenyl) amino] -5-thiazolecarboxamide,

2 '- [(3-Bromophenyl) amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2- (phenylamino) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2- (methylphenylamino) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2- (2-pyridinylamino) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [(6-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [(4-methyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [(4-ethyl-2-pyridyline) amino] -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [(4,6-dimethyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

2 '- [(6-amino-2-pyridinyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [(6-ethyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [(6-propyl-2-pyridinyl) amino] -5-thiazolecarboxamide,

2 '- [(2-amino-3-pyridinyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

2 '- [(3-amino-2-pyridinyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

2 '- [(6-amino-2-methyl-4-pyrimidinyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2 - [[6- (4-morpholinyl) -3-pyridazinyl) amino] -5-thiazolecarboxamide,

2 '- [(6-Chloro-3-pyridazinyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

N '- (2,6-Dimethylphenyl) -2- (3-pyridazinylamino) -5-thiazolecarboxamide,

2 '- [(3-aminophenyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

2 '- [(3-Bromophenyl) amino] -N- (2,6-dimethylphenyl) -5-thiazolecarboxamide,

2 '- (2-Pyridinylamino) -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(6-Methyl-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(5-Methyl-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(4-Methyl-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(3-Methyl-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(5-Bromo-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(5-Chloro-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(6-Methoxy-3-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(4-Ethyl-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(6-Ethyl-2-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(6-Chloro-3-pyridinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(2,6-Dimethyl-4-pyrimidinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(4-Methyl-2-pyrimidinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- (2-Pyrazinylamino) -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(6-Chloro-2-pyrazinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

2 '- [(3,5-Dimethyl-2-pyrazinyl) amino] -N- (2,4,6-trimethylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [[2- (4-morpholinyl) ethyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [[3- (4-morpholinyl) propyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6- [methyl [3- (methylamino) propyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [[2- (tetrahydro-2-oxo-1H-imidazol-1-yl) ethyl] amino] -4-pyrimidinyl ] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [(2-1H-imidazol-4-yl-ethyl) amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6- (4-morpholinyl-4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[((2R) -1-ethyl-2-pyrrolidinyl] methyl] amino] -2-methyl-4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[((2S) -1-ethyl-2-pyrrolidinyl] methyl] amino] -2-methyl-4-pyrimidinyl] amino] -5-thiazolecarboxamide,

2 '- [[6 - [(2S) -2-Aminocarbonyl-1-pyrrolidinyl] -2-methyl-4-pyrimidinyl] amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(2-hydroxyethyl) amino] -2-methyl-4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[4- (hydroxymethyl) -1-piperidinyl] -2-methyl-4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- [4- (2-hydroxyethyl) -1-piperazinyl] -2-methyl-4-pyrimidinyl] amino] -5-thiazolecarboxamide,

1 '- [6 - [[5 [[(2-Chloro-6-methylphenyl) amino] carbonyl-2-thiazolyl] amino] -2-methyl-4-pyrimidinyl] -4-piperidinecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [(3S) -3-methyl-1-pyrazinyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

2 '- [[6- [3- (Acetylamino) -1-pyrrolidinyl] -2-methyl-4-pyrimidinyl] amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (1-methyl-2-pyrrolidinyl) ethyl] amino] -2-methyl-4-pyrimidinyl] amino] -5- thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [[(5-methyl-2-pyrazinyl) methyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[2-methyl-6 - [[2- (1H-1,2,3-triazol-1-yl) ethyl] amino] -4-pyrimidinyl ] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (4-morpholinyl) ethyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2-dimethylamino] ethyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) 2 - [[6 - [[2-tetrahydro-2-oxo-1H-imidazol-1-yl] ethyl] amino] -4-pyrimidinyl] amino] -5- thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- [methyl- [2- (methylamino) ethyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (l-methyl-2-pyrrolidinyl) ethyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (l-pyrrolidinyl) ethyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[(1-ethyl-2-pyrrolidinyl) methyl] amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(4-piperidinylmethyl) amino] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

2 '- [[6 - [[2- (Acetylmino) ethyl] amino] 4-pyrimidinyl] amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (1H-1,2,3-triazol-1-yl) ethyl) amino] -4-pyrimidinyl] amino] - 5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- (4-morpholinyl) -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (4-morpholinyl) ethyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[3- (4-morpholinyl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- [3- (methylamino) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(3S) -3-methyl-l-piperazinyl] -2-piperidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(3-1H-imidazol-1-ylpropyl) amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(2-hydroxyethyl) amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(2-1H-imidazol-1-yl-ethyl) amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- (4-morpholinyl) -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[2- (4-morpholinyl) ethyl] amino] -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[3- (4-morpholinyl) propyl] amino] -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- (4-morpholinyl) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(3-hydroxy-1-pyrrolidinyl) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- (1H-imidazol-1-yl) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-chloro-6-methylphenyl) -2 - [[6- (3-hydroxy-1-pyrrolidinyl) -3-pyridazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- (1H-imidazol-1-yl) -3-pyridazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3- (methylamino) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3 - [(3-hydroxy-1-pyrrolidinyl) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3- (cyclopropylamino) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3- (4-morpholinyl) -2-pyrazinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3 - [[2- (4-morpholinyl) ethyl] amino] -2-pyrazinyl] amino] -5-thiazolecarboxamide,

2 '- [[3 - [[2- (Acetylamino) ethyl] amino] -2-pyrazinyl] amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (cyclohexylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (methylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (cyclopropylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(phenylmethyl) amino] -5-thiazolecarboxamide,

2 - [[2- (Acetylamino) ethyl] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[(1R) -1- (hydroxymethyl) -3-methylbutyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- (methoxymethyl) -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-chloro-6-methylphenyl) -2 - [[6- (hydroxymethyl) -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-chloro-6-methylphenyl) -2 - [[6- (4-morpholinylmethyl) -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[2- (dimethylamino) ethyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[2- (4-morpholinyl) ethyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[3- (4-morpholinyl) propyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[3- (2-oxo-1-pyrrolidinyl) propyl] amino] methyl] -4-pyrimidinyl] amino] -5- thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[(2-1H-imidazol-4-yl-ethyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[(3-1H-imidazol-1-ylpropyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[2- (2-pyridinyl) ethyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[[2- (3-pyridinyl) ethyl] amino] methyl] -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

1 '- [[6 - [[5 - [[(2-Chloro-6-methylphenyl) amino] carbonyl] -2-thiazolyl] amino] -4-pyrimidinyl] methyl] -4-piperidinecarboxamide,

2 '- [[6 - [[[2- (Acetylamino) ethyl] amino] methyl] -4-pyrimidinyl] amino] -N- (2-chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (2-naphthalenylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (2-quinolinylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (3-isoquinolinylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2- (2-quinoxalinylamino) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -4-methyl-2 - [[2-methyl-6- (4-morpholinyl) -4-pyrimidinyl] amino] -5-thiazolecarboxamide,

2 '- [[2,6-Dimethyl-4-pyrimidinyl] amino] -N-phenyl-5-thiazolecarboxamide,

2 '- [(2,6-Dimethyl-4-pyrimidinyl) methylamino] -N- (2-methylphenyl) -5-thiazolecarboxamide,

2 '- [(2,6-Dimethyl-4-pyrimidinyl) amino] -N- (2-methylphenyl) -5-thiazolecarboxamide,

N '- (3,5-Dimethoxyphenyl) -2 - [(2,6-dimethyl-4-pyrimidinyl) amino] -5-thiazolecarboxamide,

N '- [2,6-Bis (1-methylethyl) phenyl] -2 - [(2,6-dimethyl-4-pyrimidinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(2,6-dimethyl-4-pyrimidinyl) methylamino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [(2,6-dimethyl-4-pyrimidinyl) amino] -N-methyl-5-thiazolecarboxamide,

N, N- (2-Chloro-6-methylphenyl) - (4-methoxybenzyl) -2 - [(6-bromo-2-pyridinyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(6-bromo-2-pyridinyl) amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6- [4- (2-furanylcarbonyl-1-piperazinyl] -2-pyridinyl] amino] -5-thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Benzylimidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -N- (2-Chloro-6-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[4- (1H-imidazol-1-yl) butyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[5- (1H-imidazol-1-yl) pentyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[3- (4-methyl-1-piperazinyl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[4- (1H-imidazol-1-yl) phenyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[6- (1H-imidazol-1-yl) hexyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [(3-1H-imidazol-l-yl-propyl) amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -N- (4-methoxyphenyl) -5-thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -N- (4-phenoxyphenyl) -5-thiazolecarboxamide,

N '- (4-Chlorophenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -N- [1- (phenylmethyl) -1H-indazol-5-yl] - 5-thiazolecarboxamide,

N '- (2-Ethylphenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2,6-Dimethoxyphenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2,4-Dimethoxyphenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -N-phenyl-5-thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -N- (2-methylphenyl) -5-thiazolecarboxamide,

N '- (2-Chlorophenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2,6-Diethylphenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[6 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -4-methyl-5- thiazolecarboxamide,

2 '- [[6 - [[3- (1H-Imidazol-1-yl) propyl] amino] -2-pyridinyl] amino] -4-methyl-N- [1- (phenylmethyl) -1H-indazol-5 -yl] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[3 - [[3- (1H-imidazol-1-yl) propyl] amino] phenyl] amino] -5-thiazolecarboxamide,

N '- (2-Chloro-6-methylphenyl) -2 - [[5 - [[3- (1H-imidazol-1-yl) propyl] amino] -2-nitrophenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(3,4,5-trimethoxyphenyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(4-methoxyphenyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(3-methoxyphenyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-methoxyphenyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(3,5-Dimethoxyphenyl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[4- (dimethylamino) phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[4- (4-morpholinyl) phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[3- (carboxymethyl) phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[3- (3-carboxypropyl) phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[4- (carboxymethyl) phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(2-methyl-1H-benzimidazol-5-yl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[1- [3- (1H-imidazol-1-yl) propyl] -1H-benzimidazol-4-yl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[1- [2- (1H-imidazol-1-yl) ethyl] -1H-indazol-6-yl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[2- [2- (1H-imidazol-1-yl) ethyl] -2H-indazol-6-yl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(1-methyl-1H-benzimidazol-6-yl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [(1-methyl-1H-benzimidazol-5-yl) amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[2- [3- (1H-imidazol-1-yl) propyl] amino-1H-benzimidazol-5-yl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[2- (4-morpholinylmethyl) -1H-benzimidazol-5-yl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[2- (1H-imidazol-1-ylmethyl) -1H-benzimidazol-5-yl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[3 - [[5- (1H-imidazol-1-yl) -2-pyridinyl] amino] phenyl] amino] -5-thiazolecarboxamide

N- (2-Chloro-6-methylphenyl) -2 - [[3- [3- (1H-imidazol-1-yl) propoxy] phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[4- [3- (1H-imidazol-1-yl) propoxy] phenyl] amino] -5-thiazolecarboxamide,

N- (2-Chloro-6-methylphenyl) -2 - [[3 - [[[3- (1H-imidazol-1-yl) propyl] amino] sulfonyl] phenyl] amino] -5-thiazolecarboxamide and

N- (2-Chloro-6-methylphenyl) -2 - [[4 - [[[3- (1H-imidazol-1-yl) propyl] amino] sulfonyl] phenyl] amino] -5-thiazolecarboxamide.

23. A method of treating disorders caused by protein tyrosine kinases, comprising the step of administering to a subject in need thereof an effective amount of at least one compound of formula III or a salt thereof:

where Q is:

(1) 5 membered heteroaryl ring;

(2) 6 membered heteroaryl ring; or

(3) aryl cycle;

optionally substituted with one or more R ₁ groups;

Z is:

(1) simple communication;

(2) -R ₁₅ C = Ch-; or

(3) - (CH ₂ ) _m -, where m is 1-2;

X ₃ is oxygen or sulfur;

R ₁ means:

(1) hydrogen or R ₆ ,

(2) —OH or —OR ₆ ;

(3) —SH or —SR ₆ ;

(5) -SO ₃ H or -S (O) _q R ₆ ;

(6) halogen (halogen);

(7) cyano;

(8) nitro;

(9) -Z ₄ -NR ₇ R ₈ ;

(10) -Z ₄ -N (R ₉ ) -Z ₅ -NR ₁₀ R ₁₁ ;

(11) -Z ₄ -N (R ₁₂ ) -Z ₅ -R ₆ ;

(12) -P (O) (OR ₆ ) ₂ ;

R ₂ and R ₃ each independently represents

(1) hydrogen or R ₆ ,

(2) -Z ₄ -R ₆ ; or

(3) -Z ₁₃ -NR ₇ R ₈ ;

R ₄ and R ₅ :

(1) each independently, is hydrogen or R ₆ ;

(2) -Z ₄ -N (R ₉ ) -Z ₅ -NR ₁₀ R ₁₁ ;

(3) -N (R ₉ ) Z ₄ R ₆ ; or

R ₇ , R ₈ , R ₉ , R ₁₀ , R ₁₁ and R ₁₂ :

(1) each independently, is hydrogen or R ₆ ;

R ₁₃ means:

(1) cyano;

(2) nitro;

(3) -NH ₂ ;

(4) -NHOalkyl;

(5) —OH;

(6) -NHOaryl;

(7) -NHCOOalkyl;

(8) -NHCOOaryl;

(9) -NHSO ₂ alkyl;

(10) -NHSO ₂ aryl;

(11) aryl;

(12) heteroaryl;

(13) -Oalkyl; or

(14) -Oaryl;

R ₁₄ means:

(1) -NO ₂ ;

(2) -COOalkyl; or

(3) -COOaryl;

R ₁₅ means:

(1) hydrogen;

(2) alkyl;

(3) aryl;

(4) arylalkyl; or

(5) cycloalkyl;

Z ₁ , Z ₂ and Z ₃ each independently means:

(2) —OH or —OZ ₆ ;

(3) —SH or —SZ ₆ ;

(4) -C (O) _q H, -C (O) _q Z ₆ or -OC (O) _q Z ₆ ;

(5) -SO ₃ H, -S (O) _q Z ₆ ; or -S (O) _q N (Z ₉ ) Z ₆ ;

(6) halogen (halogen);

(7) cyano;

(8) nitro;

(9) -Z ₄ -NZ ₇ Z ₈ ;

(10) -Z ₄ -N (Z ₉ ) -Z ₅ -NZ ₇ Z ₈ ;

(11) -Z ₄ -N (Z ₁₀ ) -Z ₅ -Z ₆ ;

(12) -Z ₄ -N (Z ₁₀ ) -Z ₅ -H;

(13) oxo;

(14) —OC (O) —Z ₆ ;

Z ₄ and Z ₅ each independently means:

(1) simple communication;

(2) -Z ₁₁ -S (O) _q -Z ₁₂ -;

(3) -Z ₁₁ -C (O) -Z ₁₂ -;

(4) -Z ₁₁ -C (S) -Z ₁₂ -;

(5) -Z ₁₁ -OZ ₁₂ -;

(6) -Z ₁₁ -SZ ₁₂ -;

(7) -Z ₁₁ -OC (O) -Z ₁₂ -; or

(8) -Z ₁₁ -C (O) -OZ ₁₂ -;

Z ₇ , Z ₈ , Z ₉ and z ₁₀ :

(1) each independently, is hydrogen or Z ₆ ;

(2) Z ₇ and Z ₈ or Z ₆ and Z ₁₀ may together mean alkylene or alkenylene forming a 3-8 membered saturated or unsaturated ring together with the atoms to which they are bonded, this ring being unsubstituted or substituted with Z substituents ₁ , Z ₂ and Z ₃ ; or

Z ₁₁ and Z ₁₂ each independently means:

(1) simple communication;

(2) alkylene;

(3) alkenylene; or

(4) alkynylene; and

Z ₁₃ means:

(1) simple communication;

(2) -Z ₁₁ -S (O) _q -Z ₁₂ -;

(3) -Z ₁₁ -C (O) -Z ₁₂ -;

(4) -Z ₁₁ -C (S) -Z ₁₂ -;

(5) -Z ₁₁ -OZ ₁₂ -;

(6) -Z ₁₁ -SZ ₁₂ -;

(7) -Z ₁₁ -OC (O) -Z ₁₂ -;

(8) -Z ₁₁ -C (O) -OZ ₁₂ -;

(9) -C (NR ₁₃ ) -;

(10) —C (CHR ₁₄ ) -; or

(11) -C (C (R ₁₄ ) ₂ ) -.

(12)

provided that the specified connection is not

(a) a compound of formula (i):

where R _1a is alkyl or —C (O) NHNH ₂ ;

R _2a and R _3a are independently hydrogen, alkyl, —C (O) alk;

and

or R _4a is alkyl, and R _5a is alkyl or aryl;

or R _4a and R _5a together with the nitrogen atom attached to them form a morpholine ring denotes alkyl or aryl;

(b) a compound of formula (ii) or (iii):

where X is oxygen or sulfur;

R _1b is hydrogen, halogen, alkyl or haloalkyl;

R _2b is hydrogen, alkyl, aryl, aralkyl, heterocycle, heterocycloalkyl;

R _3b is alkyl, aryl, aralkyl, heterocycle, heterocycloalkyl;

R _4b is hydrogen, alkyl or aralkyl; and

R _5b is hydrogen, alkyl, aryl, aralkyl, heterocycle or heterocycloalkyl;

(c) a compound of formula (vi):

where R _4d and R _{5d are} independently hydrogen, alkyl, alkenyl or phenyl;

R ₂₇ is hydrogen or alkyl; or

(d) a compound:

24. The method according to item 23, wherein said violation due to protein tyrosine kinases is a transplant rejection.

25. The method according to item 23, wherein the specified violation of protein tyrosine kinases is rheumatoid arthritis.

26. The method according to item 23, wherein the specified violation of protein tyrosine kinases is multiple sclerosis.

27. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is an inflammatory bowel disease.

28. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is lupus.

29. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is a reaction "graft" against the "host", a homologous disease.

30. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is a mediated by T cells increased sensitivity.

31. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is psoriasis.

32. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is a Hashimoto's goiter, chronic lymphomatous thyroiditis.

33. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is Guillain-Barré syndrome.

34. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is a cancer.

35. The method according to item 23, wherein said violation due to protein tyrosine kinases is contact dermatitis.

36. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is an allergic disease.

37. The method according to item 23, wherein the specified violation of protein tyrosine kinases is asthma.

38. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is an ischemic or reperfusion injury.

39. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is atopic dermatitis (diffuse neurodermatitis).

40. The method according to item 23, wherein the specified violation of protein tyrosine kinases is an allergic rhinitis.

41. The method according to item 23, wherein the specified violation due to protein tyrosine kinases is a blockage of the lungs.

42. The method according to item 23, wherein said violation due to protein tyrosine kinases is a diabetic retinopathy.

43. The method according to item 23, wherein the specified protein tyrosine kinase is Lck.

44. The method according to item 23, wherein the specified protein tyrosine kinase is Fyn.

45. The method according to item 23, wherein the specified protein tyrosine kinase is Lyn.

46. The method according to item 23, wherein the specified protein tyrosine kinase is Hck.

47. The method according to item 23, wherein the specified protein tyrosine kinase is Fgr.

48. The method according to item 23, wherein the specified protein tyrosine kinase is Src.

49. The method according to item 23, wherein the specified protein tyrosine kinase is Yes.

50. The method according to item 23, wherein the specified protein tyrosine kinase is Blk.

51. The method according to item 23, wherein the specified protein tyrosine kinase is HER1.

52. The method according to item 23, wherein the specified protein tyrosine kinase is HER2.

53. The method according to item 23, wherein R _{2 is} not heteroaryl, and R _{3 is} not aryl without a substituent or with substituents Z ₁ , Z ₂ and one or more Z ₃ groups.

54. The method according to item 23, wherein the specified compound of formula III or its salt is administered, simultaneously or sequentially, with anti-inflammatory, antiproliferative, chemotherapeutic agent, immunosuppressive agent, anti-cancer, cytotoxic agent or PTK inhibitor (PTK), which is not a compound of the formula III or its salt.

55. The method according to item 54, wherein the specified compound of formula III or its salt is administered with one or more of the following: another PTK inhibitor (PTK); cyclosporin A; CTLA4-Ig; antibodies selected from anti-ICAM-3, anti-1L-2 receptor (Anti-Tac), anti-CD45RB, anti-CD2, anti-CD3 (OCT-3), anti-CD4, anti-CD80, anti-CD86 and monoclonal antibody OKT3; agents blocking the interaction between CD40 and gp39; fusion proteins created from CD40 and gp39; inhibitors of NF-Kappa B-function; non-steroidal anti-inflammatory drugs (NSAIDs); steroids; gold compounds; antiproliferative agents; FK506 (tacrolimus, Prograf), mycophenolate mofetil; cytotoxic drugs; TNF-α inhibitors; anti-TNF antibodies or a soluble TNF receptor; rapamycin (sirolimus (sirilimus) or rapamune (Rapamune)); leflunimide (leflunimide); cyclooxygenase-2 inhibitors; paclitaxel; cisplatin, carboplatin, doxorubicin, carminomycin, daunorubicin, aminopterin, methotrexate, metopterin, mitomycin C, ecteinascidin 743, porphyromycin, 5-fluorouracil, 6-mercaptopurine, gemcitabine, cytosine arabinoside, podophyllotinosin, etoposidinopinoside vinopinoside, vinophosphonide, tenopinoside, vinophosphate leurosin or their derivatives.

56. A method of treating a disorder mediated by T cells, comprising the step of administering to a subject in need thereof an effective amount of at least one compound according to claim 23 for this purpose.

57. The method according to p, characterized in that the activation of T cells is inhibited.

58. A pharmaceutical composition for treating a protein tyrosine kinase-related disorder, comprising a pharmaceutically acceptable carrier or diluent and at least one compound according to claim 1.

59. The compound of formula II or its salt:

where n is 1 or 2;

X ₃ is oxygen or sulfur;

A is selected from carbon or nitrogen;

B is selected from nitrogen, oxygen and sulfur;

R ₁ means:

(1) hydrogen or R ₆ ,

where R ₆ is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, cycloalkenyl, cycloalkenylalkyl, aryl, aralkyl, heterocyclo or heterocycloalkyl, each of which is unsubstituted or has substituents Z ₁ , Z ₂ and one or more (preferably one or two ) groups Z ₃ ;

(2) —OH or —OR ₆ ;

(3) —SH or —SR ₆ ;

(5) -SO ₃ H or -S (O) _q R ₆ ;

(6) halogen (halogen);

(7) cyano;

(8) nitro;

(9) -Z ₄ -NR ₇ R ₈ ;

(10) -Z ₄ -N (R ₉ ) -Z ₅ -NR ₁₀ R ₁₁ ;

(11) -Z ₄ -N (R ₁₂ ) -Z ₅ -R ₆ ;

(12) -P (O) (OR ₆ ) ₂ ;

R ₂ and R ₃ each independently represents

(1) hydrogen or R ₆ ,

(2) -Z ₄ -R ₆ ; or

(3) -Z ₁₃ -NR ₇ R ₈ ;

R ₄ and R ₅ :

(1) each independently, is hydrogen or R ₆ ;

(2) -Z ₄ -N (R ₉ ) -Z ₅ -NR ₁₀ R ₁₁ ;

(3) -N (R ₉ ) Z ₄ R ₆ ; or

R ₇ , R ₈ , R ₉ , R ₁₀ , R ₁₁ and R ₁₂ :

(1) each independently, is hydrogen or R ₆ ;

(2) R ₇ and R ₈ can together be alkylene, alkenylene, or heteroalkyl forming a 3-8 membered saturated or unsaturated ring to the nitrogen atom to which they are bonded, the ring being unsubstituted or substituted with substituents Z ₁ , Z ₂ and Z ₃ ; or

R ₁₃ means:

(1) cyano;

(2) nitro;

(3) -NH ₂ ;

(4) -HNOalkyl;

(5) —OH;

(6) -NHOaryl;

(7) -NHCOOalkyl;

(8) -NHCOOaryl;

(9) -NHSO ₂ alkyl;

(10) -NHSO ₂ aryl;

(11) aryl;

(12) heteroaryl;

(13) -Oalkyl; or

(14) -Oaryl;

R ₁₄ means:

(1) -NO ₂ ;

(2) -COOalkyl; or

(3) -COOaryl;

R ₁₅ means:

(1) hydrogen;

(2) alkyl;

(3) aryl;

(4) arylalkyl; or

(5) cycloalkyl;

Z ₁ , Z ₂ and Z ₃ each independently means:

(2) —OH or —OZ ₆ ;

(3) —SH or —SZ ₆ ;

(4) -C (O) _q H, -C (O) _q Z ₆ or -OC (O) _q Z ₆ ;

(5) -SO ₃ H, -S (O) _q Z ₆ ; or-S (O) _q N (Z ₉ ) Z ₆ ;

(6) halogen (halogen);

(7) cyano;

(8) nitro;

(9) -Z ₄ -NZ ₇ Z ₈ ;

(10) -Z ₄ -N (Z ₉ ) -Z ₅ -NZ ₇ Z ₈ ;

(11) -Z ₄ -N (Z ₁₀ ) -Z ₅ -Z ₆ ;

(12) -Z ₄ -N (Z ₁₀ ) -Z ₅ -H;

(13) oxo;

(14) —OC (O) —Z ₆ ;

Z ₄ and Z ₅ each independently means:

(1) simple communication;

(2) -Z ₁₁ -S (O) _q -Z ₁₂ -;

(3) -Z ₁₁ -C (O) -Z ₁₂ -;

(4) -Z ₁₁ -C (S) -Z ₁₂ -;

(5) -Z ₁₁ -OZ ₁₂ -;

(6) -Z ₁₁ -SZ ₁₂ -;

(7) -Z ₁₁ -OC (O) -Z ₁₂ -; or

(8) -Z ₁₁ -C (O) -OZ ₁₂ -;

Z ₇ , Z ₈ , Z ₉ and Z ₁₀ :

(1) each independently, is hydrogen or Z ₆ ;

Z ₁₁ and Z ₁₂ each independently means:

(1) simple communication;

(2) alkylene;

(3) alkenylene; or

(4) alkynylene; and

Z ₁₃ means:

(1) simple communication;

(2) -Z ₁₁ -S (O) _q -Z ₁₂ -;

(3) -Z ₁₁ -C (O) -Z ₁₂ -;

(4) -Z ₁₁ -C (S) -Z ₁₂ -;

(5) -Z ₁₁ -OZ ₁₂ -;

(6) -Z ₁₁ -SZ ₁₂ -;

(7) -Z ₁₁ -OC (O) -Z ₁₂ -;

(8) -Z ₁₁ -C (O) -OZ ₁₂ -;

(9) -C (NR ₁₃ ) -;

(10) —C (CHR ₁₄ ) -; or

(11) -C (C (R ₁₄ ) ₂ ) -.

provided that the specified connection is not

(1) a compound of formula (i):

where R _1a is alkyl or —C (O) NHNH ₂ ;

R _2a and R _3a are independently hydrogen, alkyl, —C (O) alk;

and

or R _4a is alkyl, and R _5a is alkyl or aryl;

(2) a compound of formula (vi):

where R _4d and R _{5d are} independently hydrogen, alkyl, alkenyl or phenyl;

R ₂₇ is hydrogen or alkyl;

(3) a compound of formula (vii):

where R _3e represents phenyl, pyridyl or pyridinyl, having, if necessary, as a substituent, halogen or alkyl;

R ₅₀ and R ₅₁ each independently represents hydrogen, halogen, or alkyl;

R ₅₂ and R ₅₃ , each independently, are hydrogen, halogen, alkyl, or haloalkyl;

R ₅₅ is hydrogen, halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio or alkoxycarbonyl; and n is zero or 1;

(4) a compound of formula (viii):

where R _2f and R _3f independently represent hydrogen or alkyl;

R _4f is hydrogen or alkyl; and

R _5f is alkyl, cycloalkyl, aryl, alkyl substituted aryl, alkoxy substituted aryl, nitro substituted aryl, aryl substituted aryl, aralkyl or heteroaryl;

or

(5) a compound of formula (ix):