JPH1180137A - Carbamoyltetrazole and herbicide - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a new agrochemical, especially a herbicide by using an almost new carbamoyltetrazole as an active ingredient. SOLUTION: This herbicide comprises a carbamoyltetrazole of formula I or formula II (R<1> is H, an alkyl, a cycloalkyl, a cycloalkenyl, an alkenyl, an alkoxycarbonyl, phenoxy, an alkylthio, pyrimidin-2-yl, etc.; R<2> and R<3> are each H, an alkyl, a cycloalkyl, an alkenyl, an alkynyl, an alkoxy or R<2> , R<3> and N form a 3- to 9-membered ring, etc.; W is O or S) as an active ingredient. 2-(N,N-diethylcarbamoyl)-5-methyltetrazole, etc., may be cited as the compound of the formula I. 1-(N,N-diethylcarbamoyl)-5-methyltetrazole, etc., may be cited as the compound of the formula II. The compound of the formula I or formula II is obtained by reacting a tetrazole of formula III with a halogenated carbamoyl of formula IV (Z is a halogen).

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a novel carbamoyltetrazole and a pesticide containing the same as an active ingredient, particularly a herbicide.

[0002]

2. Description of the Related Art U.S. Pat. Thiocarbamoyl) -5-aryltetrazoles are disclosed, but nothing is known about the herbicidal activity of those compounds.

[0003]

Means for Solving the Problems In view of such a situation, the present inventors have continued to study to develop a herbicide, and as a result, formula (1a) or (1b):

[0004]

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[Wherein R¹Is a hydrogen atom, C_1-8Alkyl
Group, C_3-7Cycloalkyl group, C_3-7To the cycloalkyl group
Therefore, C replaced_1-6Alkyl group, C_3-7Cycloalkene
Nyl group, C_3-7Substituted by a cycloalkenyl group
C_1-6Alkyl group, C_2-8Alkenyl group, C_2-8Alkini
Group, C_1-6C substituted by an alkoxy group_1-6Al
Kill group, C_2-6Substituted by an alkenyloxy group
C_1-6Alkyl group, C_2-6Replaced by an alkynyloxy group
Transformed C_1-6Alkyl group, C_1-6By haloalkoxy group
C replaced_1-6Alkyl group, C_2-6Haloalkenyl
C substituted by an oxy group_1-6Alkyl group, C_2-6C
C substituted by a loalkynyloxy group _1-6Archi
Group, C_1-6C substituted by an alkylthio group_1-6A
Alkyl group, C_{1 -6}Substituted by alkylsulfinyl group
Done C_1-6Alkyl group, C_1-6To alkylsulfonyl groups
Therefore, C replaced_1-6Alkyl group, C_1-8Haloalkyl
Group, C_{2- 8}Haloalkenyl group, C_2-8Haloalkynyl group,
C substituted by a cyano group_{1- 6}Alkyl group, cyano
Substituted by a group_2-6Alkenyl group, cyano group
Therefore, C replaced_2-6Alkynyl and nitro groups
Replaced by_1-6Substituted by alkyl group or nitro group
Done C_2-6Substituted by an alkenyl group or a nitro group
C_2-6Alkynyl group, C_2-6To the alkoxycarbonyl group
Therefore, C replaced_1-6Alkyl group, C_2-6Alkoxyka
C substituted by a rubonyl group_2-6Alkenyl group, C
_2-6C substituted by an alkoxycarbonyl group_2-6A
Rukinyl group, C_{2- 6}Substituted by alkylcarbonyl group
Done C_1-6Alkyl group, C_2-6Haloalkylcarbonyl
Substituted by a group_1-6Alkyl group, C_3-6Alkene
Substituted by a carbonyl group_1-6Alkyl group,
C_3-6C substituted by an alkynylcarbonyl group_1-6
Alkyl group, phenyl group (provided that the phenyl group is C_1-4A
Alkyl group, C_1-4Haloalkyl group, C_1-4An alkoxy group,
C_2-4Alkoxycarbonyl, cyano, nitro and
And one or more substituents selected from halogen atoms
It may be substituted. C) replaced by_1-6A
Alkyl group, C_2-6Alkoxycarbonyl group, benzylo
Xycarbonyl group, phenoxycarbonyl group (however,
The benzene ring of the phenoxycarbonyl group is C_1-4Alkyl
Group, C_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-6
Alkoxycarbonyl, cyano, nitro and halo
Substituted by one or more substituents selected from
It may be. ), C_2-8Alkylcarbonyl group, C
_4-8Cycloalkylcarbonyl group, C_3-7Cycloalkyl
Substituted by a group_2-6Alkylcarbonyl group, C
_3-8Alkenylcarbonyl group, C_3-8Alkynylcarboni
Group, phenylcarbonyl group (provided that phenylcarboni
Benzene ring of C_1-4Alkyl group, C_1-4Haloalk
Group, C_1-4Alkoxy group, C_2-4Alkoxycarbonyl
Group, cyano group, nitro group and halogen atom
May be substituted by one or more substituents. ),
C substituted by a phenyl group_2-8Alkenyl group (however
And the phenyl group is C_1-4Alkyl group, C_1-4Haloalkyl
Group, C_1-4Alkoxy group, C_2-4Alkoxycarbonyl
Group, cyano group, nitro group and halogen atom
May be substituted by one or more substituents. ),
C_1-8Alkoxy group, C_3-7Cycloalkoxy group, C_3-7
C substituted by a cycloalkyl group_1-6Alkoxy
Group, C_2-8Alkenyloxy group, C_2-8Alkynyloxy
Group, C_1-6C substituted by an alkoxy group_1-6Arco
C substituted by a xy or phenyl group_1-6Alkoki
Si group (however, phenyl group is C_1-4Alkyl group, C_1-4Halo
Alkyl group, C_1-4Alkoxy group, C_2-4Alkoxycal
From bonyl, cyano, nitro and halogen atoms
May be substituted by one or more selected substituents
No. ), Phenoxy group (provided that the phenoxy group benzene
Ring is C_1-4Alkyl group, C_1-4Haloalkyl group, C _1-4A
Lucoxy group, C_2-4Alkoxycarbonyl group, cyano
One or more selected from a group, a nitro group and a halogen atom
It may be substituted by a substituent. ), C _1-8Al
Kirthio group, C_3-7Cycloalkylthio group, C_3-7Cyclo
C substituted by an alkyl group_1-6Alkylthio group,
C_2-8Alkenylthio group, C_2-8Alkynylthio group, C
_1-6C substituted by an alkoxy group_1-6Alkylthio
Group substituted by a phenyl group_1-6Alkylthio
Group (provided that the phenyl group is C_1-4Alkyl group, C_1-4Haloa
Alkyl group, C_1-4Alkoxy group, C_2-4Alkoxycarbo
Nyl, cyano, nitro and halogen atoms
May be substituted by one or more substituents
No. ), A phenylthio group (provided that the phenylthio group
Zen ring is C_1-4Alkyl group, C_1-4Haloalkyl group, C
_1-4Alkoxy group, C_2-4Alkoxycarbonyl group, shea
At least one selected from a nitro group, a nitro group and a halogen atom
May be substituted. ), C_1-8A
Rukylsulfinyl group, C_3-7Cycloalkyl sulfy
Nyl group, C_3-7C substituted by a cycloalkyl group
_1-6Alkylsulfinyl group, C_2-8Alkenyl sulphie
Nyl group, C_2-8Alkynylsulfinyl group, C_1-6Arco
C substituted by a xy group_1-6Alkylsulfinyl
Group substituted by a phenyl group_1-6Alkylsul
Finyl group (However, phenyl group is C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from atoms
You may. ), Phenylsulfinyl group (provided that phenyl
The benzene ring of the rusulfinyl group is C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from atoms
You may. ), C_1-8Alkylsulfonyl group, C_3-7Shiku
Loalkylsulfonyl group, C_3-7By cycloalkyl group
C replaced_1-6Alkylsulfonyl group, C_2-8Al
Kenylsulfonyl group, C_2-8Alkynylsulfonyl group,
C_1-6C substituted by an alkoxy group_1-6Alkyls
C substituted by a ruphonyl group or a phenyl group_1-6Al
Killsulfonyl group (provided that the phenyl group is_1-4Alkyl
Group, C_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4
Alkoxycarbonyl, cyano, nitro and halo
Substituted by one or more substituents selected from
It may be. ), Phenylsulfonyl group (however,
The benzene ring of the phenylsulfonyl group is C_1-4Alkyl group,
C_1-4Haloalkyl group, C_1-4Alkoxy group, C_{Two -Four}Al
Coxycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from
May be. ), R^FourR^FiveC replaced by N_1-6A
Alkyl group, R^FourR^FiveN, R^FourR^FiveNCO, R^FourR^FiveNSO_Two,
Naphthyl group (however, C_1-4Alkyl group, C_1-4Haloalk
Group, C_1-4Alkoxy group, C_2-4Alkoxycarbonyl
Group, cyano group, nitro group and halogen atom
May be substituted by one or more substituents. ),
5- to 6-membered heteroaryl group (however, C_1-4Alkyl group,
C_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Al
Coxycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from
May be. ), A 5- to 6-membered heteroarylmethyl group (provided that
And the 5-6 membered heteroaryl group is C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from atoms
You may. ), A 5- to 6-membered heteroaryloxy group (provided that
And the 5-6 membered heteroaryl group is C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from atoms
You may. ), A 5- to 6-membered heteroarylthio group (provided that
A 5-6 membered heteroaryl group is C_1-4Alkyl group, C_1-4C
Loalkyl group, C_1-4Alkoxy group, C_2-4Alkoxyka
Rubonyl group, cyano group, nitro group and halogen atom
May be substituted with one or more substituents selected from
No. ), Phenyl group (however, C_1-4Alkyl group, C_1-4C
Loalkyl group, C_1-4Alkoxy group, C_2-4Alkoxyka
A rubonyl, cyano, nitro or halogen atom
May be substituted with one or more substituents selected from
No. ) Substituted phenyl group, oxirane ring
(However, C_1-4May be substituted by an alkyl group
No. ) Or a phenyl group (provided that C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl group, cyano group, nitro group, halogen source
Child, C_1-4Haloalkoxy and phenylsulfonyl
Substituted by one or more substituents selected from
Or cross-linked by a methylenedioxy group
May be. ) Represents a 5- or 6-membered heteroaryl
Ofen-2-yl group, thiophen-3-yl group, fura
2-yl group, furan-3-yl group, pyrrole-1-
Yl group, pyrrol-2-yl group, pyrrol-3-yl
Group, oxazol-2-yl group, oxazol-4-i
Group, oxazol-5-yl group, thiazol-2-i
Group, thiazol-4-yl group, thiazol-5-yl
Group, imidazol-1-yl group, imidazol-2-i
Group, imidazol-4-yl group, imidazole-5
Yl group, isoxazol-3-yl group, isoxazo
4-yl group, isoxazol-5-yl group, a
Sothiazol-3-yl group, isothiazol-4-yl
Group, isothiazol-5-yl group, pyrazol-1-i
Group, pyrazol-3-yl group, pyrazol-4-yl
Group, pyrazol-5-yl group, 1,3,4-oxadia
Zol-2-yl group, 1,3,4-thiadiazole-2
-Yl group, 1,3,4-triazol-1-yl group,
1,3,4-triazol-2-yl group, 1,2,4-
Oxadiazol-3-yl group, 1,2,4-oxadi
Azole-5-yl group, 1,2,4-thiadiazole-
3-yl group, 1,2,4-thiadiazol-5-yl
A 1,2,4-triazol-1-yl group, 1,2,2
4-triazol-3-yl group, 1,2,4-triazo
5-yl group, 1,2,3-oxadiazole-4
-Yl group, 1,2,3-oxadiazol-5-yl
Group, 1,2,3-thiadiazol-3-yl group, 1,
2,3-thiadiazol-5-yl group, 1,2,3-to
Liazol-1-yl group, 1,2,3-triazole-
4-yl group, 1,2,3-triazol-5-yl group,
1,2,3,4-tetrazol-1-yl group, 1,2,2
3,4-tetrazol-5-yl group, 1,2,3,5-
Tetrazol-1-yl group, 1,2,3,5-tetrazo
-4-yl group, pyridine-2-yl group, pyridine-
3-yl group, pyridin-4-yl group, pyrimidine-2-
Yl group, pyrimidin-5-yl group, pyrimidine-4-i
Group, pyrazin-2-yl group, pyridazin-3-yl
Group, pyridazin-4-yl group, 1,3,5-triazine
-2-yl group, 1,2,4-triazin-3-yl group,
1,2,4-triazin-5-yl group or 1,2,4
-Triazin-6-yl group, quinolin-2-yl group,
Nolin-3-yl group, isoquinolin-1-yl group, iso
A quinolin-3-yl group, a quinoxalin-2-yl group or
Represents a benzothiazol-2-yl group;^TwoAnd R^Three
Is independently a hydrogen atom, C_1-6Alkyl group, C_3-6
Cycloalkyl group, C_2-4Alkenyl group, C_2-4Alkini
Group, C_1-4Haloalkyl group, C_3-6With a cycloalkyl group
Replaced C_1-2Alkyl group, C_1-4Alkoxy group (however
Then R ^TwoAnd R^ThreeCannot simultaneously represent an alkoxy group
No. ), C_1-4Alkoxy C_1-4Alkyl group, C_1-4Al
Kircio C_1-4Alkyl group, phenyl group (provided that phenyl
The radical is C_1-4Alkyl group, C_1-4Haloalkyl group, C_1-4
Alkoxy, cyano, nitro and halogen atoms
Even if substituted by one or more substituents selected from
Good. ) Or a benzyl group, provided that R^TwoAnd R^Three
Constitutes a 3- to 9-membered ring with the nitrogen atom
Oxygen atom, sulfur atom, C_1-4Alkyl group
A nitrogen atom, a carbonyl group,
It may contain a honyl group or an unsaturated bond, and the ring is
_1-4The ring may be substituted by an alkyl group,
_1-4The ring may be bridged by alkylene,
May be condensed by a benzene ring;^FourAnd R^Five
Is independently a hydrogen atom, C_1-6Alkyl group, C_3-6
Cycloalkyl group, C_2-4Alkenyl group, C_2-4Alkini
Group, C_1-4Haloalkyl group, C_3-6With a cycloalkyl group
Replaced C_1-2Alkyl group, C_1-4Alkoxy group (however
Then R ^FourAnd R^FiveCannot simultaneously represent an alkoxy group
No. ), C_1-4Alkoxy C_1-4Alkyl group, C_1-4Al
Kircio C_1-4Alkyl group, phenyl group (provided that phenyl
The radical is C_1-4Alkyl group, C_1-4Haloalkyl group, C_1-4
Alkoxy, cyano, nitro and halogen atoms
Even if substituted by one or more substituents selected from
Good. ) Or a benzyl group, provided that R^FourAnd R^Five
Constitutes a 3- to 9-membered ring with the nitrogen atom
Oxygen atom, sulfur atom, C_1-4Alkyl group
A nitrogen atom, a carbonyl group,
It may contain a honyl group or an unsaturated bond, and the ring is
_1-4The ring may be substituted by an alkyl group,
_1-4The ring may be bridged by alkylene,
W may be fused with an oxygen ring
Alternatively, it represents a sulfur atom. Carbamoylte represented by
Torazol has strong herbicidal activity and advanced selection for crops
The present inventors have found that the present invention has properties, and have completed the present invention.

The present invention relates to a pesticide containing the carbamoyltetrazole as an active ingredient, particularly a herbicide, and R ¹
Is a phenyl group (however, one or more substituents selected from C _1-4 alkyl groups, C _1-4 haloalkyl groups, C _1-4 alkoxy groups, C _2-4 alkoxycarbonyl groups, cyano groups, nitro groups and halogen atoms) May be substituted by a group.)
And carbamoyltetrazole.

[0007]

BEST MODE FOR CARRYING OUT THE INVENTION The substituents R ¹ , R ² and R ³ of carbamoyltetrazole and its intermediates are specifically listed. However, the symbols have the following meanings. Me: methyl group, Et: ethyl group, Pr-n: normal propyl group, Pr-iso: isopropyl group, Bu-
n: normal butyl group, Bu-iso: isobutyl group,
Bu-sec: secondary butyl group, Bu-ter
t: tert-butyl group, Pen-n: normal pentyl group, Hex-n: normal hexyl group, Hex-
iso: isohexyl group, Hep-n: normal heptyl group, Oct-n: normal octyl group, Pr-cy
c: cyclopropyl group, Bu-cyc: cyclobutyl group, Pen-cyc: cyclopentyl group, Hex-cy
c: cyclohexyl group, Ph: phenyl group, Naph:
Naphthyl group,

[0008]

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[0009]

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[0010]

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[0011]

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[0012]

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[0013]

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[0014]

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[Substituent R of carbamoyltetrazole¹
Examples of H, Me, Et, Pr-n, Pr-iso, Bu-n, Bu-iso, Bu-sec, Bu-
tert, Pen-n, Et_TwoCH, Hex-n, Hep-n, Oct-n, Me (Pr-n) C
H, Me (Bu-n) CH, Et (Pr-n) CH, Et (Bu-n) CH, (Pr-n)_TwoCH,
Me (Pen-n) CH, Et (Pen-n) CH, (Pr-n) (Bu-n) CH, Me_TwoCHCH_Two
CH_Two, Pr-cyc, Bu-cyc, Pen-cyc, Hex-cyc, CH_TwoPr-cyc,
CH_TwoBu-cyc, CH_TwoPen-cyc, CH_TwoHex-cyc, CH_TwoCH_TwoPr-cyc, C
H_TwoCH = CH_Two, CH_TwoCH = CHMe, CH_TwoCH = CHEt, CH_TwoCMe = CH_Two, CH_TwoC
H_TwoCH = CH_Two, CH_TwoCH_TwoCH = CHMe, CH_TwoCH = CMe_Two, CHMeCH = CH_Two, CH
_TwoCMe = CHMe, CHMeCH = CHMe, CH_TwoCMe = CHEt, CH_TwoCH_TwoCH = CM
e_Two, CH_TwoCMe = CMe_Two, CH_TwoC CH, CH_TwoC CMe, CH_TwoC CEt, C
H_TwoCH_TwoC CH, CH_TwoCH_TwoC CMe, CHMeC CH, CHMeC CMe, C
H_TwoOMe, CH_TwoOEt, CH_TwoOPr-n, CH _TwoOPr-iso, CH_TwoOBu-n, CH_Two
OBu-iso, CH_TwoOBu-sec, CH_TwoOBu-tert, CH_TwoCH_TwoOMe, CH_TwoCH
_TwoOEt, CH_TwoCH_TwoOPr-n, CH_TwoCH_TwoCH_TwoOMe, CH_TwoCH_TwoCH_TwoOEt, CH_Two
CH_TwoCH_TwoCH_TwoOMe, CH_TwoOCH_TwoCH = CH_Two, CH_TwoOCH_TwoCH = CHMe, CH_TwoCH
_TwoOCH_TwoCH = CH_Two, CH_TwoCH_TwoOCH_TwoCH = CHMe, CH_TwoOCH_TwoC CH, CH_TwoO
CH_TwoC CMe, CH_TwoOCHMeC CH, CH_TwoOCMe_TwoC CH, CH_TwoCH_TwoOCH
_TwoC CH, CH_TwoCH_TwoOCH_TwoC CMe, CH_TwoCH_TwoOCHMeC CH, CH_TwoCH_Two
OCMe_TwoC CH,

CH ₂ OCHF ₂ , CH ₂ OCF ₃ , CH ₂ OCF ₂ CF ₃ , CH ₂ CH ₂ O
CHF ₂ , CH ₂ CH ₂ OCF ₃ , CH ₂ CH ₂ OCF ₂ CF ₃ , CH ₂ OCH ₂ CF ₃ , CH ₂ CH
₂ OCH ₂ CF ₃ , CH ₂ OCH ₂ CHF ₂ , CH ₂ CH ₂ OCH ₂ CHF ₂ , CH ₂ OCH ₂ CH
₂ F, CH ₂ OCH ₂ CH ₂ Cl, CH ₂ OCH ₂ CH ₂ Br, CH ₂ CH ₂ OCH ₂ CH ₂ F, CH
₂ CH ₂ OCH ₂ CH ₂ Cl, CH ₂ CH ₂ OCH ₂ CH ₂ Br, CH ₂ OCH ₂ CH = CHCl, CH
₂ CH ₂ OCH ₂ CH = CHCl, CH ₂ OCH ₂ CH = CHBr, CH ₂ CH ₂ OCH ₂ CH = CHB
r, CH ₂ OCH ₂ CF = CF ₂ , CH ₂ CH ₂ OCH ₂ CF = CF ₂ , CH ₂ OCH = CHCl, CH
₂ CH ₂ OCH = CHCl, CH ₂ OCF = CF ₂ , CH ₂ CH ₂ OCF = CF ₂ , CH ₂ OCF ₂ CF
= CF ₂ , CH ₂ CH ₂ OCF ₂ CF = CF ₂ , CH ₂ OCH ₂ CH = CF ₂ , CH ₂ CH ₂ OCH ₂ C
H = CF ₂ , CH ₂ OCH ₂ CH = CHCF ₃ , CH ₂ CH ₂ OCH ₂ CH = CHCF ₃ , CH ₂ OCH
₂ C CI, CH ₂ OCH ₂ CH ₂ C CI, CH ₂ CH ₂ OCH ₂ C CI, CH ₂ OCH ₂ C
CCF ₃ , CH ₂ CH ₂ OCH ₂ C CCF ₃ , CH ₂ OCMe ₂ C CI, CH ₂ CH ₂ OC
Me ₂ C CI, CH ₂ OCMe ₂ C CCF ₃ , CH ₂ CH ₂ OCMe ₂ C CCF ₃ ,

CH_TwoSMe, CH_TwoSEt, CH_TwoSPr-n, CH_TwoSPr-iso,
CH_TwoSBu-n, CH_TwoSBu-iso, CH_TwoSBu-sec, CH_TwoSBu-tert, CH_TwoC
H_TwoSMe, CH_TwoCH_TwoSEt, CH_TwoCH_TwoSPr-n, CH_TwoCH_TwoSPr-iso, CH_TwoC
H_TwoSBu-n, CH_TwoCH_TwoSBu-iso, CH_TwoCH_TwoSBu-sec, CH_TwoCH_TwoSBu-t
ert, CH_TwoCH_TwoCH_TwoSMe, CH_TwoCH_TwoCH _TwoSEt, CH_TwoCH_TwoCH_TwoSPr-n, C
H_TwoCH_TwoCH_TwoSPr-iso, CH_TwoCH_TwoCH_TwoSBu-n, CH_TwoCH_TwoCH_TwoSBu-iso,
 CH_TwoCH_TwoCH_TwoSBu-sec, CH_TwoCH_TwoCH_TwoSBu-tert, CH_TwoS (O) Me, C
H_TwoS (O) Et, CH_TwoS (O) Pr-n, CH_TwoS (O) Pr-iso, CH_TwoS (O) Bu-n,
 CH_TwoS (O) Bu-iso, CH_TwoS (O) Bu-sec, CH_TwoS (O) Bu-tert, CH_Two
CH_TwoS (O) Me, CH_TwoCH_TwoS (O) Et, CH_TwoCH_TwoS (O) Pr-n, CH_TwoCH_TwoS
(O) Pr-iso, CH_TwoSO_TwoMe, CH_TwoSO_TwoEt, CH_TwoSO_TwoPr-n, CH_TwoSO_TwoP
r-iso, CH_TwoSO_TwoBu-n, CH_TwoSO_TwoBu-iso, CH_TwoSO_TwoBu-sec, CH_Two
SO_TwoBu-tert, CH_TwoCH_TwoSO_TwoMe, CH_TwoCH_TwoSO_TwoEt, CH_TwoCH_TwoSO_TwoPr-
n, CH_TwoCH_TwoSO _TwoPr-iso,

CH ₂ F, CH ₂ Cl, CH ₂ Br, CH ₂ I, CHF ₂ , CHCl ₂ ,
_{CHBr 2, CF 3, CCl 3} , CBr 3, CClF 2, CBrF 2, CH 2 FCH 2, CH
F ₂ CH ₂ , CF ₃ CH ₂ , CF ₃ CF ₂ , CF ₃ CF ₂ CF ₂ , ClCH ₂ CH ₂ , BrCH ₂ C
H ₂ , CCl ₃ CH ₂ , CF ₃ CH ₂ CH ₂ , CCl ₃ CH ₂ CH ₂ , ClCH ₂ CH ₂ CH ₂ , F
CH ₂ CH ₂ CH ₂ , CF ₃ CF ₂ CH ₂ , ClCH ₂ CH ₂ CH ₂ CH ₂ , CH ₂ CH = CHCl,
CH ₂ CH = CHBr, CH ₂ CH = CF ₂ , CH ₂ CF = CF ₂ , CH ₂ CH = CHCF ₃ , CH ₂
CH = CBrMe, CH ₂ CH = CClMe, CH ₂ CH = CCF ₃ Me, CF ₂ CF = CF ₂ , CH
₂ C CI, CH ₂ CH ₂ C CI, CH ₂ C CCF ₃ , CH ₂ CH ₂ C CCF ₃ , CH
₂ CN, CH ₂ CH ₂ CN, CHMeCN, CH ₂ CHMeCN, CH ₂ CMe ₂ CN, CH ₂ CH =
CHCN, CH ₂ CH (CN) CH = CH ₂ , CH ₂ C (CN) = CH ₂ , CH ₂ C (CN) = CHM
e, CH ₂ CH (CN) C CH, CH ₂ CH (CN) C CMe, CH (CN) C CH, C
H ₂ NO ₂ , CH ₂ CH ₂ NO ₂ , CHMeNO ₂ , CH ₂ CHMeNO ₂ , CH ₂ CMe ₂ NO ₂ ,
CH ₂ CH = CHNO ₂ , CH ₂ CH (NO ₂ ) CH = CH ₂ , CH ₂ C (NO ₂ ) = CH ₂ , CH ₂ C
(NO ₂ ) = CHMe, CH ₂ CH (NO ₂ ) C CH, CH ₂ CH (NO ₂ ) C CMe, CH
(NO ₂ ) C CH,

CH_TwoCO_TwoMe, CH_TwoCO_TwoEt, CH_TwoCO_TwoPr-n, CH_TwoCO_Two
Pr-iso, CH_TwoCO_TwoBu-n, CHMeCO_TwoMe, CHMeCO_TwoEt, CH_TwoCH_TwoCO
_TwoMe, CH_TwoCH_TwoCO_TwoEt, CH_TwoCHMeCO_TwoMe, CH_TwoCH_TwoCH_TwoCO_TwoMe, CH
_TwoCH = CHCO_TwoMe, CH_TwoCH = CHCO_TwoEt, CH_TwoCH = CHCO_TwoPr-n, CH_TwoCH
= CMeCO_TwoMe, CH_TwoCMe = CHCO_TwoMe, CHMeCH = CHCO_TwoMe, CHMeCH =
CHCO_TwoEt, CH_TwoCH_TwoCH = CHCO_TwoMe, CH_TwoCH = CHCH_TwoCO_TwoMe, CH_TwoCC
CO_TwoMe, CH_TwoC CCO_TwoEt, CH_TwoC CCO_TwoPr-n, CH_TwoCH_TwoC CCO_Two
Me, CH_TwoCHMeC CCO_TwoMe, CH_TwoCMe_TwoC CCO_TwoMe, CH_TwoC CCH_Two
CO_TwoMe, CH_TwoCOMe, CH_TwoCOEt, CH_TwoCOPr-n, CH_TwoCH _TwoCOMe, CH
_TwoCH_TwoCOEt, CH_TwoCHMeCOMe, CH_TwoCMe_TwoCOMe, CH_TwoCOCF_Three, CH_TwoC
OCCl_Three, CH_TwoCH_TwoCOCF_Three, CH_TwoCOCH_TwoCF_Three, CH_TwoCOCH_TwoCHF_Two, CH_Two
COCH_TwoCHCl_Two, CH_TwoCOCH_TwoF, CH_TwoCOCH_TwoCl, CH_TwoCOCH_TwoBr, CH_TwoC
OCH = CH_Two, CH_TwoCOCH = CHMe, CH_TwoCOCH_TwoCH = CH_Two, CH_TwoCH_TwoCOCH =
CH_Two, CH_TwoCH_TwoCOCH = CHMe, CH_TwoCOC CH, CH_TwoCOC CMe, CH_Two
COCH_TwoC CH, CH_TwoCH_TwoCOC CH, CH_TwoCH_TwoCOC CMe,

[0020] PhCH_Two, 2-Cl-PhCH_Two, 3-Cl-PhCH_Two, 4-Cl-Ph
CH_Two, 2,4-Cl_Two-PhCH_Two, 3,5-Cl_Two-PhCH_Two, 2,6-Cl_Two-PhCH_Two,
2,3-Cl_Two-PhCH_Two, 2,5-Cl_Two-PhCH_Two, 2-F-PhCH_Two, 3-F-PhC
H_Two, 4-F-PhCH_Two, 2-F-4-Cl-PhCH_Two, 2-Br-PhCH_Two, 3-Br-Ph
CH_Two, 4-Br-PhCH_Two, 2-Me-PhCH_Two, 3-Me-PhCH_Two, 4-Me-PhCH
_Two, 2,4-Me_Two-PhCH_Two, 3,5-Me_Two-PhCH_Two, 2,6-Me_Two-PhCH_Two, 2,
3-Me_Two-PhCH_Two, 2,5-Me_Two-PhCH_Two, 2-MeO-PhCH_Two, 3-MeO-PhC
H_Two, 4-MeO-PhCH_Two, 2-CF_Three-PhCH_Two, 3-CF_Three-PhCH_Two, 4-CF_Three-P
hCH_Two, 2,4,6-Cl_Three-PhCH_Two, 2,3,5-Cl_Three-PhCH_Two, 2,3,4-Cl_Three-
PhCH_Two, 2-NO_Two-PhCH_Two, 3-NO_Two-PhCH_Two, 4-NO_Two-PhCH_Two, 2-CN
-PhCH_Two, 3-CN-PhCH_Two, 4-CN-PhCH_Two, PhCH_TwoCH_Two, 2-Cl-PhC
H_TwoCH_Two, 3-Cl-PhCH_TwoCH_Two, 4-Cl-PhCH_TwoCH_Two, 2,4-Cl_Two-PhCH_Two
CH_Two, 3,5-Cl_Two-PhCH_TwoCH_Two, 2,6-Cl_Two-PhCH_TwoCH_Two, 2,3-Cl_Two-P
hCH_TwoCH_Two, 2,5-Cl_Two-PhCH_TwoCH_Two, 2-F-PhCH_TwoCH_Two, 3-F-PhCH_Two
CH_Two, 4-F-PhCH_TwoCH_Two, 2-F-4-Cl-PhCH_TwoCH_Two, 2-Br-PhCH_TwoCH
_Two, 3-Br-PhCH_TwoCH_Two, 4-Br-PhCH_TwoCH_Two, 2-Me-PhCH_TwoCH_Two, 3-
Me-PhCH_TwoCH_Two, 4-Me-PhCH_TwoCH_Two, 2,4-Me_Two-PhCH_TwoCH_Two, 3,5-
Me_Two-PhCH_TwoCH_Two, 2,6-Me_Two-PhCH_TwoCH_Two, 2,3-Me_Two-PhCH_TwoCH_Two,
2,5-Me_Two-PhCH_TwoCH_Two, 2-MeO-PhCH_TwoCH_Two, 3-MeO-PhCH_TwoCH_Two,Four
-MeO-PhCH_TwoCH_Two, 2-CF_Three-PhCH_TwoCH_Two, 3-CF_Three-PhCH_TwoCH_Two, 4-C
F_Three-PhCH_TwoCH_Two, 2,4,6-Cl _Three-PhCH_TwoCH_Two, 2,3,5-Cl_Three-PhCH_TwoCH
_Two, 2,3,4-Cl_Three-PhCH_TwoCH_Two, 2-NO_Two-PhCH_TwoCH_Two, 3-NO _Two-PhCH_Two
CH_Two, 4-NO_Two-PhCH_TwoCH_Two, 2-CN-PhCH_TwoCH_Two, 3-CN-PhCH_TwoCH_Two,
 4-CN-PhCH_TwoCH_Two,

PhCHMe, 2-Cl-PhCHMe, 3-Cl-PhCHMe, 4-Cl
-PhCHMe, 2,4-Cl_Two-PhCHMe, 3,5-Cl_Two-PhCHMe, 2,6-Cl_Two-P
hCHMe, 2,3-Cl_Two-PhCHMe, 2,5-Cl_Two-PhCHMe, 2-F-PhCHMe,
 3-F-PhCHMe, 4-F-PhCHMe, 2-F-4-Cl-PhCHMe, 2-Br-PhC
HMe, 3-Br-PhCHMe, 4-Br-PhCHMe, 2-Me-PhCHMe, 3-Me-P
hCHMe, 4-Me-PhCHMe, PhCHMeCH_Two, 2-Cl-PhCHMeCH_Two, 3-C
l-PhCHMeCH_Two, 4-Cl-PhCHMeCH_Two, 2,4-Cl_Two-PhCHMeCH_Two, 3,
5-Cl_Two-PhCHMeCH_Two, 2,6-Cl_Two-PhCHMeCH_Two, 2,3-Cl_Two-PhCHMe
CH_Two, 2,5-Cl_Two-PhCHMeCH_Two, 2-F-PhCHMeCH_Two, 3-F-PhCHMeC
H_Two, 4-F-PhCHMeCH_Two, 2-F-4-Cl-PhCHMeCH_Two, 2-Br-PhCHMe
CH_Two, 3-Br-PhCHMeCH_Two, 4-Br-PhCHMeCH_Two, 2-Me-PhCHMeCH
_Two, 3-Me-PhCHMeCH_Two, 4-Me-PhCHMeCH_Two, PhCH_TwoCHMe, 2-Cl
-PhCH_TwoCHMe, 3-Cl-PhCH_TwoCHMe, 4-Cl-PhCH_TwoCHMe, 2,4-Cl
_Two-PhCH_TwoCHMe, 3,5-Cl_Two-PhCH_TwoCHMe, 2,6-Cl_Two-PhCH_TwoCHMe,
 2,3-Cl_Two-PhCH_TwoCHMe, 2,5-Cl_Two-PhCH _TwoCHMe, 2-F-PhCH_TwoCH
Me, 3-F-PhCH_TwoCHMe, 4-F-PhCH_TwoCHMe, 2-F-4-Cl-PhCH_TwoCH
Me, 2-Br-PhCH_TwoCHMe, 3-Br-PhCH_TwoCHMe, 4-Br-PhCH_TwoCHMe,
 2-Me-PhCH_TwoCHMe, 3-Me-PhCH_TwoCHMe, 4-Me-PhCH_TwoCHMe, P
hCMe_Two, PhCHMeCHMe, PhCH_TwoCH_TwoCH_Two, PhCH_TwoCH_TwoCH_TwoCH_Two, PhC
H_TwoCH_TwoCH_TwoCH_TwoCH_Two, PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoCH_Two, PhCHEt, PhCH
Pr-n, PhCHPr-iso, Ph_TwoCH,

CO ₂ Me, CO ₂ Et, CO ₂ Pr-n, CO ₂ Pr-iso, CO ₂ B
un, CO ₂ Bu-iso, CO ₂ Bu-sec, CO ₂ Bu-tert, CO ₂ Pen-n, C
O ₂ CH ₂ Ph, PhOCO, 2-Cl-PhOCO, 3-Cl-PhOCO, 4-Cl-PhOC
O, 2,4-Cl ₂ -PhOCO, 3,5-Cl ₂ -PhOCO, 2,6-Cl ₂ -PhOCO, 2,
3-Cl ₂ -PhOCO, 2,5-Cl ₂ -PhOCO, 2-F-PhOCO, 3-F-PhOCO,
4-F-PhOCO, 2-F-4-Cl-PhOCO, 2-Br-PhOCO, 3-Br-PhOCO,
4-Br-PhOCO, 2-Me-PhOCO, 3-Me-PhOCO, 4-Me-PhOCO, 2,
4-Me ₂ -PhOCO, 3,5-Me ₂ -PhOCO, 2,6-Me ₂ -PhOCO, 2,3-Me ₂
-PhOCO, 2,5-Me ₂ -PhOCO, 2-MeO-PhOCO, 3-MeO-PhOCO, 4
-MeO-PhOCO, 2-CF ₃ -PhOCO, 3-CF ₃ -PhOCO, 4-CF ₃ -PhOCO,
2,4,6-Cl ₃ -PhOCO, 2,3,5-Cl ₃ -PhOCO, 2,3,4-Cl ₃ -PhOC
O, 2-NO ₂ -PhOCO, 3-NO ₂ -PhOCO, 4-NO ₂ -PhOCO, 2-CN-PhO
CO, 3-CN-PhOCO, 4-CN-PhOCO,

MeCO, EtCO, (Pr-n) CO, (Pr-iso) CO, (Bu-
n) CO, (Bu-iso) CO, (Bu-sec) CO, (Bu-tert) CO, (Pen-n)
CO, (Hex-n) CO, (Hep-n) CO, (Pr-cyc) CO, (Bu-cyc) CO,
(Pen-cyc) CO, (Hex-cyc) CO, COCH_TwoPr-cyc, COCH_TwoBu-cy
c, COCH_TwoPen-cyc, COCH_TwoHex-cyc, COCH_TwoCH_TwoPr-cyc, COC
H_TwoCH = CH_Two, COCH_TwoCH = CHMe, COCH_TwoCH = CHEt, COCH_TwoCMe = C
H_Two, COCH_TwoCH_TwoCH = CH_Two, COCH_TwoCH_TwoCH = CHMe, COCH_TwoCH = CMe_Two,
COCHMeCH = CH_Two, COCH_TwoCMe = CHMe, COCHMeCH = CHMe, COCH_TwoC
Me = CHEt, COCH_TwoCH_TwoCH = CMe_Two, COCH_TwoCMe = CMe_Two, COCH_TwoC C
H, COCH_TwoC CMe, COCH_TwoC CEt, COCH_TwoCH_TwoC CH, COCH_TwoC
H_TwoC CMe, COCHMeCCH, COCHMeC CMe, PhCO, 2-Cl-PhC
O, 3-Cl-PhCO, 4-Cl-PhCO, 2,4-Cl_Two-PhCO, 3,5-Cl_Two-PhC
O, 2,6-Cl_Two-PhCO, 2,3-Cl_Two-PhCO, 2,5-Cl_Two-PhCO, 2-F-P
hCO, 3-F-PhCO, 4-F-PhCO, 2-F-4-Cl-PhCO, 2-Br-PhCO,
 3-Br-PhCO, 4-Br-PhCO, 2-Me-PhCO, 3-Me-PhCO, 4-Me-
PhCO, 2,4-Me_Two-PhCO, 3,5-Me_Two-PhCO, 2,6-Me_Two-PhCO, 2,
3-Me _Two-PhCO, 2,5-Me_Two-PhCO, 2-MeO-PhCO, 3-MeO-PhCO,
4-MeO-PhCO, 2-CF_Three-PhCO, 3-CF_Three-PhCO, 4-CF_Three-PhCO, 2,
4,6-Cl_Three-PhCO, 2,3,5-Cl_Three-PhCO, 2,3,4-Cl_Three-PhCO, 2-NO
_Two-PhCO, 3-NO_Two-PhCO, 4-NO_Two-PhCO, 2-CN-PhCO, 3-CN-Ph
CO, 4-CN-PhCO,

OMe, OEt, OPr-n, OPr-iso, OBu-n, OBu-i
so, OBu-sec, OBu-tert, OPen-n, Et_TwoCHO, OHex-n, OHe
p-n, OOct-n, Me (Pr-n) CHO, Me (Bu-n) CHO, Et (Pr-n) CH
O, Et (Bu-n) CHO, (Pr-n)_TwoCHO, Me (Pen-n) CHO, Et (Pen-
n) CHO, (Pr-n) (Bu-n) CHO, Me_TwoCHCH_TwoCH_TwoO, OPr-cyc, OBu
-cyc, OPen-cyc, OHex-cyc, OCH_TwoPr-cyc, OCH_TwoBu-cyc,
OCH_TwoPen-cyc, OCH_TwoHex-cyc, OCH_TwoCH_TwoPr-cyc, OCH_TwoCH = CH
_Two, OCH_TwoCH = CHMe, OCH_TwoCH = CHEt, OCH_TwoCMe = CH_Two, OCH_TwoCH_TwoC
H = CH_Two, OCH_TwoCH_TwoCH = CHMe, OCH_TwoCH = CMe_Two, OCHMeCH = CH _Two, O
CH_TwoCMe = CHMe, OCHMeCH = CHMe, OCH_TwoCMe = CHEt, OCH_TwoCH_TwoCH
= CMe_Two, OCH_TwoCMe = CMe _Two, OCH_TwoC CH, OCH_TwoC CMe, OCH_TwoC
 CEt, OCH_TwoCH_TwoC CH, OCH_TwoCH_TwoC CMe, OCHMeC CH, OC
HMeC CMe, OCH_TwoOMe, OCH_TwoOEt, OCH_TwoOPr-n, OCH_TwoOPr-is
o, OCH_TwoOBu-n, OCH_TwoOBu-iso, OCH_TwoOBu-sec, OCH_TwoOBu-ter
t, OCH_TwoCH_TwoOMe, OCH_TwoCH_TwoOEt, OCH_TwoCH_TwoOPr-n, OCH_TwoCH_TwoCH
_TwoOMe, OCH_TwoCH_TwoCH_TwoOEt, OCH_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoO, 2-Cl-PhCH_TwoO, 3-Cl-PhCH_TwoO, 4-Cl
-PhCH_TwoO, 2,4-Cl_Two-PhCH_TwoO, 3,5-Cl_Two-PhCH_TwoO, 2,6-Cl_Two-P
hCH_TwoO, 2,3-Cl_Two-PhCH_TwoO, 2,5-Cl_Two-PhCH_TwoO, 2-F-PhCH_TwoO,
 3-F-PhCH_TwoO, 4-F-PhCH_TwoO, 2-F-4-Cl-PhCH_TwoO, 2-Br-PhC
H_TwoO, 3-Br-PhCH_TwoO, 4-Br-PhCH_TwoO, 2-Me-PhCH_TwoO, 3-Me-P
hCH_TwoO, 4-Me-PhCH_TwoO, 2,4-Me_Two-PhCH_TwoO, 3,5-Me_Two-PhCH
_TwoO, 2,6-Me_Two-PhCH_TwoO, 2,3-Me_Two-PhCH_TwoO, 2,5-Me_Two-PhCH
_TwoO, 2-MeO-PhCH_TwoO, 3-MeO-PhCH_TwoO, 4-MeO-PhCH_TwoO, 2-CF
_Three-PhCH_TwoO, 3-CF_Three-PhCH_TwoO, 4-CF_Three-PhCH_TwoO, 2,4,6-Cl_Three-Ph
CH_TwoO, 2,3,5-Cl_Three-PhCH_TwoO, 2,3,4-Cl_Three-PhCH_TwoO, 2-NO_Two-Ph
CH_TwoO, 3-NO_Two-PhCH_TwoO, 4-NO_Two-PhCH_TwoO, 2-CN-PhCH_TwoO, 3-CN
-PhCH_TwoO, 4-CN-PhCH_TwoO, PhCH_TwoCH_TwoO, 2-Cl-PhCH_TwoCH_TwoO, 3
-Cl-PhCH_TwoCH_TwoO, 4-Cl-PhCH_TwoCH_TwoO, 2,4-Cl_Two-PhCH_TwoCH_TwoO,
3,5-Cl_Two-PhCH_TwoCH_TwoO, 2,6-Cl_Two-PhCH_TwoCH_TwoO, 2,3-Cl_Two-PhCH
_TwoCH_TwoO, 2,5-Cl_Two-PhCH_TwoCH_TwoO, 2-F-PhCH_TwoCH_TwoO, 3-F-PhCH_Two
CH_TwoO, 4-F-PhCH_TwoCH_TwoO, 2-F-4-Cl-PhCH_TwoCH_TwoO, 2-Br-PhCH
_TwoCH_TwoO, 3-Br-PhCH_TwoCH_TwoO, 4-Br-PhCH_TwoCH_TwoO, 2-Me-PhCH_TwoCH
_TwoO, 3-Me-PhCH_TwoCH_TwoO, 4-Me-PhCH_TwoCH_TwoO, 2,4-Me_Two-PhCH_TwoC
H_TwoO, 3,5-Me_Two-PhCH_TwoCH_TwoO, 2,6-Me_Two-PhCH_TwoCH_TwoO, 2,3-Me_Two
-PhCH_TwoCH_TwoO, 2,5-Me_Two-PhCH_TwoCH_TwoO, 2-MeO-PhCH_TwoCH_TwoO, 3-
MeO-PhCH_TwoCH_TwoO, 4-MeO-PhCH_TwoCH_TwoO, 2-CF_Three-PhCH_TwoCH_TwoO, 3
-CF_Three-PhCH_TwoCH_TwoO, 4-CF_Three-PhCH_TwoCH_TwoO, 2,4,6-Cl_Three-PhCH_TwoCH
_TwoO, 2,3,5-Cl_Three-PhCH_TwoCH_TwoO, 2,3,4-Cl_Three-PhCH_TwoCH_TwoO, 2-NO
_Two-PhCH_TwoCH_TwoO, 3-NO_Two-PhCH_TwoCH_TwoO, 4-NO_Two-PhCH_TwoCH_TwoO, 2-C
N-PhCH_TwoCH_TwoO, 3-CN-PhCH_TwoCH_TwoO, 4-CN-PhCH _TwoCH_TwoO,

PhCH (Me) O, 2-Cl-PhCH (Me) O, 3-Cl-PhCH (M
e) O, 4-Cl- PhCH (Me) O, 2,4-Cl 2 -PhCH (Me) O, 3,5-Cl 2 -Ph
CH (Me) O, 2,6-Cl ₂ -PhCH (Me) O, 2,3-Cl ₂ -PhCH (Me) O, 2,5
-Cl ₂ -PhCH (Me) O, 2-F-PhCH (Me) O, 3-F-PhCH (Me) O, 4-F-
PhCH (Me) O, 2-F-4-Cl-PhCH (Me) O, 2-Br-PhCH (Me) O, 3-B
r-PhCH (Me) O, 4-Br-PhCH (Me) O, 2-Me-PhCH (Me) O, 3-Me-
PhCH (Me) O, 4-Me-PhCH (Me) O, PhCHMeCH ₂ O, 2-Cl-PhCHMe
CH ₂ O, 3-Cl-PhCHMeCH ₂ O, 4-Cl-PhCHMeCH ₂ O, 2,4-Cl ₂ -PhC
HMeCH ₂ O, 3,5-Cl ₂ -PhCHMeCH ₂ O, 2,6-Cl ₂ -PhCHMeCH ₂ O,
2,3-Cl ₂ -PhCHMeCH ₂ O, 2,5-Cl ₂ -PhCHMeCH ₂ O, 2-F-PhCHMe
CH ₂ O, 3-F-PhCHMeCH ₂ O, 4-F-PhCHMeCH ₂ O, 2-F-4-Cl-PhC
HMeCH ₂ O, 2-Br-PhCHMeCH ₂ O, 3-Br-PhCHMeMe ₂ O, 4-Br-Ph
CHMeCH ₂ O, 2-Me-PhCHMeCH ₂ O, 3-Me-PhCHMeCH ₂ O, 4-Me-P
hCHMeCH ₂ O, PhCH ₂ CH, 2-Cl-PhCH ₂ CH (Me) O, 3-Cl-PhCH ₂ CH
(Me) O, 4-Cl-PhCH ₂ CH (Me) O, 2,4-Cl ₂ -PhCH ₂ CH (Me) O, 3,
5-Cl ₂ -PhCH ₂ CH (Me) O, 2,6-Cl ₂ -PhCH ₂ CH (Me) O, 2,3-Cl _2-
PhCH ₂ CH (Me) O, 2,5-Cl ₂ -PhCH ₂ CH (Me) O, 2-F-PhCH ₂ CH (M
e) O, 3-F-PhCH ₂ CH (Me) O, 4-F-PhCH ₂ CH (Me) O, 2-F-4-Cl-
PhCH ₂ CH (Me) O, 2-Br-PhCH ₂ CH (Me) O, 3-Br-PhCH ₂ CH (Me)
O, 4-Br-PhCH ₂ CH (Me) O, 2-Me-PhCH ₂ CH (Me) O, 3-Me-PhCH
₂ CH (Me) O, 4-Me-PhCH ₂ CH (Me) O, PhCMe ₂ O, PhCHMeCH (Me)
O, PhCH ₂ CH ₂ CH ₂ O, PhCH ₂ CH ₂ CH ₂ CH ₂ O, PhCH ₂ CH ₂ CH ₂ CH ₂ CH
₂ O, PhCH ₂ CH ₂ CH ₂ CH ₂ CH ₂ CH ₂ O,

PhO, 2-Cl-PhO, 3-Cl-PhO, 4-Cl-PhO, 2,4
-Cl ₂ -PhO, 3,5-Cl ₂ -PhO, 2,6-Cl ₂ -PhO, 2,3-Cl ₂ -PhO,
2,5-Cl ₂ -PhO, 2-F-PhO, 3-F-PhO, 4-F-PhO, 2-F-4-Cl-P
hO, 2-Br-PhO, 3-Br-PhO, 4-Br-PhO, 2-Me-PhO, 3-Me-P
hO, 4-Me-PhO, 2,4-Me ₂ -PhO, 3,5-Me ₂ -PhO, 2,6-Me ₂ -Ph
O, 2,3-Me ₂ -PhO, 2,5-Me ₂ -PhO, 2-MeO-PhO, 3-MeO-PhO,
4-MeO-PhO, 2-CF ₃ -PhO, 3-CF ₃ -PhO, 4-CF ₃ -PhO, 2,4,6-
Cl ₃ -PhO, 2,3,5-Cl ₃ -PhO, 2,3,4-Cl ₃ -PhO, 2-NO ₂ -PhO, 3
-NO ₂ -PhO, 4-NO ₂ -PhO, 2,4- (NO ₂ ) ₂ -PhO, 2-CN-PhO, 3-C
N-PhO, 4-CN-PhO,

SMe, SEt, SPr-n, SPr-iso, SBu-n, SBu-i
so, SBu-sec, SBu-tert, SPen-n, Et_TwoCHS, SHex-n, SHe
p-n, SOct-n, Me (Pr-n) CHS, Me (Bu-n) CHS, Et (Pr-n) CH
S, Et (Bu-n) CHS, (Pr-n)_TwoCHS, Me (Pen-n) CHS, Et (Pen-
n) CHS, (Pr-n) (Bu-n) CHS, Me_TwoCHCH_TwoCH_TwoS, SPr-cyc, SBu
-cyc, SPen-cyc, SHex-cyc, SCH_TwoPr-cyc, SCH_TwoBu-cyc,
SCH_TwoPen-cyc, SCH_TwoHex-cyc, SCH_TwoCH_TwoPr-cyc, SCH_TwoCH = CH
_Two, SCH_TwoCH = CHMe, SCH_TwoCH = CHEt, SCH_TwoCMe = CH_Two, SCH_TwoCH_TwoC
H = CH_Two, SCH_TwoCH_TwoCH = CHMe, SCH_TwoCH = CMe_Two, SCHMeCH = CH _Two, S
CH_TwoCMe = CHMe, SCHMeCH = CHMe, SCH_TwoCMe = CHEt, SCH_TwoCH_TwoCH
= CMe_Two, SCH_TwoCMe = CMe _Two, SCH_TwoC CH, SCH_TwoC CMe, SCH_TwoC
 CEt, SCH_TwoCH_TwoC CH, SCH_TwoCH_TwoC CMe, SCHMeC CH, SC
HMeC CMe, SCH_TwoOMe, SCH_TwoOEt, SCH_TwoOPr-n, SCH_TwoOPr-is
o, SCH_TwoOBu-n, SCH_TwoOBu-iso, SCH_TwoOBu-sec, SCH_TwoOBu-ter
t, SCH_TwoCH_TwoOMe, SCH_TwoCH_TwoOEt, SCH_TwoCH_TwoOPr-n, SCH_TwoCH_TwoCH
_TwoOMe, SCH_TwoCH_TwoCH_TwoOEt, SCH_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoS, 2-Cl-PhCH_TwoS, 3-Cl-PhCH_TwoS, 4-Cl
-PhCH_TwoS, 2,4-Cl_Two-PhCH_TwoS, 3,5-Cl_Two-PhCH_TwoS, 2,6-Cl_Two-P
hCH_TwoS, 2,3-Cl_Two-PhCH_TwoS, 2,5-Cl_Two-PhCH_TwoS, 2-F-PhCH_TwoS,
 3-F-PhCH_TwoS, 4-F-PhCH_TwoS, 2-F-4-Cl-PhCH_TwoS, 2-Br-PhC
H_TwoS, 3-Br-PhCH_TwoS, 4-Br-PhCH_TwoS, 2-Me-PhCH_TwoS, 3-Me-P
hCH_TwoS, 4-Me-PhCH_TwoS, 2,4-Me_Two-PhCH_TwoS, 3,5-Me_Two-PhCH
_TwoS, 2,6-Me_Two-PhCH_TwoS, 2,3-Me_Two-PhCH_TwoS, 2,5-Me_Two-PhCH
_TwoS, 2-MeO-PhCH_TwoS, 3-MeO-PhCH_TwoS, 4-MeO-PhCH_TwoS, 2-CF
_Three-PhCH_TwoS, 3-CF_Three-PhCH_TwoS, 4-CF_Three-PhCH_TwoS, 2,4,6-Cl_Three-Ph
CH_TwoS, 2,3,5-Cl_Three-PhCH_TwoS, 2,3,4-Cl_Three-PhCH_TwoS, 2-NO_Two-Ph
CH_TwoS, 3-NO_Two-PhCH_TwoS, 4-NO_Two-PhCH_TwoS, 2-CN-PhCH_TwoS, 3-CN
-PhCH_TwoS, 4-CN-PhCH_TwoS, PhCH_TwoCH_TwoS, 2-Cl-PhCH_TwoCH_TwoS, 3
-Cl-PhCH_TwoCH_TwoS, 4-Cl-PhCH_TwoCH_TwoS, 2,4-Cl_Two-PhCH_TwoCH_TwoS,
3,5-Cl_Two-PhCH_TwoCH_TwoS, 2,6-Cl_Two-PhCH_TwoCH_TwoS, 2,3-Cl_Two-PhCH
_TwoCH_TwoS, 2,5-Cl_Two-PhCH_TwoCH_TwoS, 2-F-PhCH_TwoCH_TwoS, 3-F-PhCH_Two
CH_TwoS, 4-F-PhCH_TwoCH_TwoS, 2-F-4-Cl-PhCH_TwoCH_TwoS, 2-Br-PhCH
_TwoCH_TwoS, 3-Br-PhCH_TwoCH_TwoS, 4-Br-PhCH_TwoCH_TwoS, 2-Me-PhCH_TwoCH
_TwoS, 3-Me-PhCH_TwoCH_TwoS, 4-Me-PhCH_TwoCH_TwoS, 2,4-Me_Two-PhCH_TwoC
H_TwoS, 3,5-Me_Two-PhCH_TwoCH_TwoS, 2,6-Me_Two-PhCH_TwoCH_TwoS, 2,3-Me_Two
-PhCH_TwoCH_TwoS, 2,5-Me_Two-PhCH_TwoCH_TwoS, 2-MeO-PhCH_TwoCH_TwoS, 3-
MeO-PhCH_TwoCH_TwoS, 4-MeO-PhCH_TwoCH_TwoS, 2-CF_Three-PhCH_TwoCH_TwoS, 3
-CF_Three-PhCH_TwoCH_TwoS, 4-CF_Three-PhCH_TwoCH_TwoS, 2,4,6-Cl_Three-PhCH_TwoCH
_TwoS, 2,3,5-Cl_Three-PhCH_TwoCH_TwoS, 2,3,4-Cl_Three-PhCH_TwoCH_TwoS, 2-NO
_Two-PhCH_TwoCH_TwoS, 3-NO_Two-PhCH_TwoCH_TwoS, 4-NO_Two-PhCH_TwoCH_TwoS, 2-C
N-PhCH_TwoCH_TwoS, 3-CN-PhCH_TwoCH_TwoS, 4-CN-PhCH _TwoCH_TwoS, PhCH
(Me) S, 2-Cl-PhCH (Me) S, 3-Cl-PhCH (Me) S, 4-Cl-PhCH (M
e) S, 2,4-Cl _Two-PhCH (Me) S, 3,5-Cl_Two-PhCH (Me) S, 2,6-Cl_Two
-PhCH (Me) S, 2,3-Cl_Two-PhCH (Me) S, 2,5-Cl_Two-PhCH (Me) S,
2-F-PhCH (Me) S, 3-F-PhCH (Me) S, 4-F-PhCH (Me) S, 2-F-4
-Cl-PhCH (Me) S, 2-Br-PhCH (Me) S, 3-Br-PhCH (Me) S, 4-B
r-PhCH (Me) S, 2-Me-PhCH (Me) S, 3-Me-PhCH (Me) S, 4-Me-
PhCH (Me) S, PhCHMeCH_TwoS, 2-Cl-PhCHMeCH_TwoS, 3-Cl-PhCHM
eCH_TwoS, 4-Cl-PhCHMeCH_TwoS, 2,4-Cl_Two-PhCHMeCH_TwoS, 3,5-Cl
_Two-PhCHMeCH_TwoS, 2,6-Cl_Two-PhCHMeCH_TwoS, 2,3-Cl_Two-PhCHMeCH
_TwoS, 2,5-Cl_Two-PhCHMeCH_TwoS, 2-F-PhCHMeCH_TwoS, 3-F-PhCHMe
CH_TwoS, 4-F-PhCHMeCH_TwoS, 2-F-4-Cl-PhCHMeCH_TwoS, 2-Br-Ph
CHMeCH_TwoS, 3-Br-PhCHMeCH_TwoS, 4-Br-PhCHMeCH_TwoS, 2-Me-P
hCHMeCH_TwoS, 3-Me-PhCHMeCH_TwoS, 4-Me-PhCHMeCH_TwoS, PhCH_Two
CH, 2-Cl-PhCH_TwoCH (Me) S, 3-Cl-PhCH_TwoCH (Me) S, 4-Cl-PhC
H_TwoCH (Me) S, 2,4-Cl_Two-PhCH_TwoCH (Me) S, 3,5-Cl_Two-PhCH_TwoCH (M
e) S, 2,6-Cl_Two-PhCH_TwoCH (Me) S, 2,3-Cl_Two-PhCH_TwoCH (Me) S,
2,5-Cl_Two-PhCH_TwoCH (Me) S, 2-F-PhCH_TwoCH (Me) S, 3-F-PhCH_TwoC
H (Me) S, 4-F-PhCH_TwoCH (Me) S, 2-F-4-Cl-PhCH_TwoCH (Me) S, 2
-Br-PhCH_TwoCH (Me) S, 3-Br-PhCH_TwoCH (Me) S, 4-Br-PhCH_TwoCH
(Me) S, 2-Me-PhCH_TwoCH (Me) S, 3-Me-PhCH_TwoCH (Me) S, 4-Me-
PhCH_TwoCH (Me) S, PhCMe_TwoS, PhCHMeCH (Me) S, PhCH_TwoCH_TwoCH
_TwoS, PhCH_TwoCH_TwoCH_TwoCH_TwoS, PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoS, PhCH_TwoCH_TwoC
H_TwoCH_TwoCH_TwoCH_TwoS,

PhS, 2-Cl-PhS, 3-Cl-PhS, 4-Cl-PhS, 2,4
-Cl ₂ -PhS, 3,5-Cl ₂ -PhS, 2,6-Cl ₂ -PhS, 2,3-Cl ₂ -PhS,
2,5-Cl ₂ -PhS, 2-F-PhS, 3-F-PhS, 4-F-PhS, 2-F-4-Cl-P
hS, 2-Br-PhS, 3-Br-PhS, 4-Br-PhS, 2-Me-PhS, 3-Me-P
hS, 4-Me-PhS, 2,4-Me ₂ -PhS, 3,5-Me ₂ -PhS, 2,6-Me ₂ -Ph
S, 2,3-Me ₂ -PhS, 2,5-Me ₂ -PhS, 2-MeO-PhS, 3-MeO-PhS,
4-MeO-PhS, 2-CF ₃ -PhS, 3-CF ₃ -PhS, 4-CF ₃ -PhS, 2,4,6-
Cl ₃ -PhS, 2,3,5-Cl ₃ -PhS, 2,3,4-Cl ₃ -PhS, 2-NO ₂ -PhS, 3
-NO ₂ -PhS, 4-NO ₂ -PhS, 2,4- (NO ₂ ) ₂ -PhS, 2-CN-PhS, 3-C
N-PhS, 4-CN-PhS,

S (O) Me, S (O) Et, S (O) Pr-n, S (O) Pr-iso,
S (O) Bu-n, S (O) Bu-iso, S (O) Bu-sec, S (O) Bu-tert, S (O)
Pen-n, Et_TwoCHS (O), S (O) Hex-n, S (O) Hep-n, S (O) Oct-n,
 Me (Pr-n) CHS (O), Me (Bu-n) CHS (O), Et (Pr-n) CHS (O), E
t (Bu-n) CHS (O), (Pr-n)_TwoCHS (O), Me (Pen-n) CHS (O), Et
(Pen-n) CHS (O), (Pr-n) (Bu-n) CHS (O), Me_TwoCHCH_TwoCH_TwoS
(O), S (O) Pr-cyc, S (O) Bu-cyc, S (O) Pen-cyc, S (O) Hex-
cyc, S (O) CH_TwoPr-cyc, S (O) CH_TwoBu-cyc, S (O) CH_TwoPen-cyc,
 S (O) CH_TwoHex-cyc, S (O) CH_TwoCH_TwoPr-cyc, S (O) CH_TwoCH = CH _Two,
S (O) CH_TwoCH = CHMe, S (O) CH_TwoCH = CHEt, S (O) CH_TwoCMe = CH_Two, S
(O) CH_TwoCH_TwoCH = CH_Two, S (O) CH_TwoCH_TwoCH = CHMe, S (O) CH_TwoCH = CM
e_Two, S (O) CHMeCH = CH_Two, S (O) CH_TwoCMe = CHMe, S (O) CHMeCH = CH
Me, S (O) CH_TwoCMe = CHEt, S (O) CH_TwoCH_TwoCH = CMe_Two, S (O) CH_TwoCMe
= CMe_Two, S (O) CH_TwoCCH, S (O) CH_TwoC CMe, S (O) CH_TwoC CEt, S
(O) CH_TwoCH_TwoC CH, S (O) CH_TwoCH_TwoC CMe, S (O) CHMeC CH, S
(O) CHMeC CMe, S (O) CH_TwoOMe, S (O) CH_TwoOEt, S (O) CH_TwoOPr-
n, S (O) CH_TwoOPr-iso, S (O) CH_TwoOBu-n, S (O) CH_TwoOBu-iso, S
(O) CH_TwoOBu-sec, S (O) CH_TwoOBu-tert, S (O) CH_TwoCH_TwoOMe, S
(O) CH_TwoCH_TwoOEt, S (O) CH_TwoCH_TwoOPr-n, S (O) CH_TwoCH_TwoCH_TwoOMe, S
(O) CH_TwoCH_TwoCH_TwoOEt, S (O) CH_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoS (O), 2-Cl-PhCH_TwoS (O), 3-Cl-PhCH_TwoS
(O), 4-Cl-PhCH_TwoS (O), 2,4-Cl_Two-PhCH_TwoS (O), 3,5-Cl_Two-Ph
CH_TwoS (O), 2,6-Cl_Two-PhCH_TwoS (O), 2,3-Cl_Two-PhCH_TwoS (O), 2,5
-Cl_Two-PhCH_TwoS (O), 2-F-PhCH_TwoS (O), 3-F-PhCH_TwoS (O), 4-F-
PhCH_TwoS (O), 2-F-4-Cl-PhCH_TwoS (O), 2-Br-PhCH_TwoS (O), 3-B
r-PhCH_TwoS (O), 4-Br-PhCH_TwoS (O), 2-Me-PhCH_TwoS (O), 3-Me-
PhCH_TwoS (O), 4-Me-PhCH_TwoS (O), 2,4-Me_Two-PhCH_TwoS (O), 3,5-
Me_Two-PhCH_TwoS (O), 2,6-Me_Two-PhCH_TwoS (O), 2,3-Me_Two-PhCH_TwoS
(O), 2,5-Me_Two-PhCH_TwoS (O), 2-MeO-PhCH_TwoS (O), 3-MeO-PhC
H_TwoS (O), 4-MeO-PhCH_TwoS (O), 2-CF_Three-PhCH_TwoS (O), 3-CF_Three-Ph
CH_TwoS (O), 4-CF_Three-PhCH_TwoS (O), 2,4,6-Cl_Three-PhCH_TwoS (O), 2,
3,5-Cl_Three-PhCH_TwoS (O), 2,3,4-Cl_Three-PhCH_TwoS (O), 2-NO_Two-PhCH
_TwoS (O), 3-NO_Two-PhCH_TwoS (O), 4-NO_Two-PhCH_TwoS (O), 2-CN-PhCH
_TwoS (O), 3-CN-PhCH_TwoS (O), 4-CN-PhCH_TwoS (O), PhCH_TwoCH_TwoS
(O), 2-Cl-PhCH_TwoCH_TwoS (O), 3-Cl-PhCH_TwoCH_TwoS (O), 4-Cl-Ph
CH_TwoCH_TwoS (O), 2,4-Cl_Two-PhCH_TwoCH_TwoS (O), 3,5-Cl_Two-PhCH_TwoCH_Two
S (O), 2,6-Cl_Two-PhCH_TwoCH_TwoS (O), 2,3-Cl_Two-PhCH_TwoCH_TwoS (O),
2,5-Cl_Two-PhCH_TwoCH_TwoS (O), 2-F-PhCH_TwoCH_TwoS (O), 3-F-PhCH_TwoC
H_TwoS (O), 4-F-PhCH_TwoCH_TwoS (O), 2-F-4-Cl-PhCH_TwoCH_TwoS (O), 2
-Br-PhCH_TwoCH_TwoS (O), 3-Br-PhCH_TwoCH_TwoS (O), 4-Br-PhCH_TwoCH_Two
S (O), 2-Me-PhCH_TwoCH_TwoS (O), 3-Me-PhCH_TwoCH_TwoS (O), 4-Me-Ph
CH_TwoCH_TwoS (O), 2,4-Me_Two-PhCH_TwoCH_TwoS (O), 3,5-Me_Two-PhCH _TwoCH_Two
S (O), 2,6-Me_Two-PhCH_TwoCH_TwoS (O), 2,3-Me_Two-PhCH_TwoCH_TwoS (O),
2,5-Me_Two-PhCH_TwoCH_TwoS (O), 2-MeO-PhCH_TwoCH_TwoS (O), 3-MeO-Ph
CH_TwoCH_TwoS (O), 4-MeO-PhCH_TwoCH_TwoS (O), 2-CF_Three-PhCH_TwoCH_TwoS
(O), 3-CF_Three-PhCH_TwoCH_TwoS (O), 4-CF_Three-PhCH_TwoCH_TwoS (O), 2,4,6
-Cl_Three-PhCH_TwoCH_TwoS (O), 2,3,5-Cl_Three-PhCH_TwoCH_TwoS (O), 2,3,4-C
l_Three-PhCH_TwoCH_TwoS (O), 2-NO_Two-PhCH_TwoCH_TwoS (O), 3-NO_Two-PhCH_TwoCH_Two
S (O), 4-NO_Two-PhCH_TwoCH_TwoS (O), 2-CN-PhCH_TwoCH_TwoS (O), 3-CN-
PhCH_TwoCH_TwoS (O), 4-CN-PhCH_TwoCH_TwoS (O),

PhCH (Me) S (O), 2-Cl-PhCH (Me) S (O), 3-Cl-
PhCH (Me) S (O), 4-Cl-PhCH (Me) S (O), 2,4-Cl_Two-PhCH (Me) S
(O), 3,5-Cl_Two-PhCH (Me) S (O), 2,6-Cl_Two-PhCH (Me) S (O),
2,3-Cl_Two-PhCH (Me) S (O), 2,5-Cl_Two-PhCH (Me) S (O), 2-F-Ph
CH (Me) S (O), 3-F-PhCH (Me) S (O), 4-F-PhCH (Me) S (O), 2-F
-4-Cl-PhCH (Me) S (O), 2-Br-PhCH (Me) S (O), 3-Br-PhCH (M
e) S (O), 4-Br-PhCH (Me) S (O), 2-Me-PhCH (Me) S (O), 3-Me
-PhCH (Me) S (O), 4-Me-PhCH (Me) S (O), PhCHMeCH_TwoS (O), 2
-Cl-PhCHMeCH_TwoS (O), 3-Cl-PhCHMeCH_TwoS (O), 4-Cl-PhCHMe
CH_TwoS (O), 2,4-Cl_Two-PhCHMeCH_TwoS (O), 3,5-Cl_Two-PhCHMeCH_TwoS
(O), 2,6-Cl_Two-PhCHMeCH_TwoS (O), 2,3-Cl_Two-PhCHMeCH_TwoS (O),
 2,5-Cl_Two-PhCHMeCH_TwoS (O), 2-F-PhCHMeCH_TwoS (O), 3-F-PhC
HMeCH_TwoS (O), 4-F-PhCHMeCH_TwoS (O), 2-F-4-Cl-PhCHMeCH_TwoS
(O), 2-Br-PhCHMeCH_TwoS (O), 3-Br-PhCHMeCH_TwoS (O), 4-Br-
PhCHMeCH_TwoS (O), 2-Me-PhCHMeCH_TwoS (O), 3-Me-PhCHMeCH_TwoS
(O), 4-Me-PhCHMeCH_TwoS (O), PhCH_TwoCH, 2-Cl-PhCH_TwoCH (Me)
S (O), 3-Cl-PhCH_TwoCH (Me) S (O), 4-Cl-PhCH_TwoCH (Me) S (O),
2,4-Cl_Two-PhCH_TwoCH (Me) S (O), 3,5-Cl_Two-PhCH_TwoCH (Me) S (O),
2,6-Cl_Two-PhCH_TwoCH (Me) S (O), 2,3-Cl_Two-PhCH_TwoCH (Me) S (O),
2,5-Cl_Two-PhCH_TwoCH (Me) S (O), 2-F-PhCH_TwoCH (Me) S (O), 3-F-
PhCH_TwoCH (Me) S (O), 4-F-PhCH_TwoCH (Me) S (O), 2-F-4-Cl-PhC
H_TwoCH (Me) S (O), 2-Br-PhCH_TwoCH (Me) S (O), 3-Br-PhCH_TwoCH (M
e) S (O), 4-Br-PhCH_TwoCH (Me) S (O), 2-Me-PhCH_TwoCH (Me) S
(O), 3-Me-PhCH_TwoCH (Me) S (O), 4-Me-PhCH_TwoCH (Me) S (O), P
hCMe_TwoS (O), PhCHMeCH (Me) S (O), PhCH_TwoCH_TwoCH _TwoS (O), PhCH
_TwoCH_TwoCH_TwoCH_TwoS (O), PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoS (O), PhCH_TwoCH_TwoCH_Two
CH_TwoCH_TwoCH_TwoS (O),

PhS (O), 2-Cl-PhS (O), 3-Cl-PhS (O), 4-Cl
-PhS (O), 2,4-Cl ₂ -PhS (O), 3,5-Cl ₂ -PhS (O), 2,6-Cl ₂ -P
hS (O), 2,3-Cl ₂ -PhS (O), 2,5-Cl ₂ -PhS (O), 2-F-PhS (O),
3-F-PhS (O), 4-F-PhS (O), 2-F-4-Cl-PhS (O), 2-Br-PhS
(O), 3-Br-PhS (O), 4-Br-PhS (O), 2-Me-PhS (O), 3-Me-P
hS (O), 4-Me-PhS (O), 2,4-Me ₂ -PhS (O), 3,5-Me ₂ -PhS
(O), 2,6-Me ₂ -PhS (O), 2,3-Me ₂ -PhS (O), 2,5-Me ₂ -PhS
(O), 2-MeO-PhS (O), 3-MeO-PhS (O), 4-MeO-PhS (O), 2-C
F ₃ -PhS (O), 3-CF ₃ -PhS (O), 4-CF ₃ -PhS (O), 2,4,6-Cl ₃ -P
hS (O), 2,3,5-Cl ₃ -PhS (O), 2,3,4-Cl ₃ -PhS (O), 2-NO ₂ -P
hS (O), 3-NO ₂ -PhS (O), 4-NO ₂ -PhS (O), 2,4- (NO ₂ ) ₂ -PhS
(O), 2-CN-PhS (O), 3-CN-PhS (O), 4-CN-PhS (O),

SO_TwoMe, SO_TwoEt, SO_TwoPr-n, SO_TwoPr-iso, SO_TwoB
u-n, SO_TwoBu-iso, SO_TwoBu-sec, SO_TwoBu-tert, SO_TwoPen-n, E
t_TwoCHSO_Two, SO_TwoHex-n, SO_TwoHep-n, SO_TwoOct-n, Me (Pr-n) CHS
O_Two, Me (Bu-n) CHSO_Two, Et (Pr-n) CHSO_Two, Et (Bu-n) CHSO_Two,
(Pr-n)_TwoCHSO_Two, Me (Pen-n) CHSO_Two, Et (Pen-n) CHSO_Two, (Pr-
n) (Bu-n) CHSO_Two, Me_TwoCHCH_TwoCH_TwoSO_Two, SO_TwoPr-cyc, SO_TwoBu-cy
c, SO_TwoPen-cyc, SO_TwoHex-cyc, SO_TwoCH_TwoPr-cyc, SO_TwoCH_TwoBu-
cyc, SO_2CH_TwoPen-cyc, SO_TwoCH_TwoHex-cyc, SO_TwoCH_TwoCH_TwoPr-cy
c, SO_TwoCH_TwoCH = CH_Two, SO_TwoCH_TwoCH = CHMe, SO_TwoCH_TwoCH = CHEt, SO_TwoC
H_TwoCMe = CH_Two, SO_TwoCH_TwoCH_TwoCH = CH_Two, SO_TwoCH_TwoCH_TwoCH = CHMe, SO_TwoC
H_TwoCH = CMe_Two, SO_TwoCHMeCH = CH_Two, SO_TwoCH_TwoCMe = CHMe, SO_TwoCHMeC
H = CHMe, SO_TwoCH_TwoCMe = CHEt, SO_TwoCH_TwoCH_TwoCH = CMe _Two, SO_TwoCH_Twocm
e = CMe_Two, SO_TwoCH_TwoC CH, SO_TwoCH_TwoC CMe, SO_TwoCH_TwoC CEt, S
O_TwoCH_TwoCH_TwoCCH, SO_TwoCH_TwoCH_TwoC CMe, SO_TwoCHMeC CH, SO_TwoCHM
eC CMe, SO_TwoCH_TwoOMe, SO_TwoCH_TwoOEt, SO_TwoCH_TwoOPr-n, SO_TwoCH_TwoO
Pr-iso, SO_TwoCH_TwoOBu-n, SO_TwoCH_TwoOBu-iso, SO_TwoCH_TwoOBu-sec,
 SO_TwoCH_TwoOBu-tert, SO_TwoCH_TwoCH_TwoOMe, SO_TwoCH_TwoCH_TwoOEt, SO_TwoCH
_TwoCH_TwoOPr-n, SO_TwoCH_TwoCH_TwoCH_TwoOMe, SO_TwoCH_TwoCH_TwoCH_TwoOEt, SO_TwoCH
_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoSO_Two, 2-Cl-PhCH_TwoSO_Two, 3-Cl-PhCH_TwoS
O_Two, 4-Cl-PhCH_TwoSO_Two, 2,4-Cl_Two-PhCH_TwoSO_Two, 3,5-Cl_Two-PhCH_TwoS
O_Two, 2,6-Cl_Two-PhCH_TwoSO_Two, 2,3-Cl_Two-PhCH_TwoSO_2, 2,5-Cl_Two-Ph
CH_TwoSO_Two, 2-F-PhCH_TwoSO_Two, 3-F-PhCH_TwoSO_Two, 4-F-PhCH_TwoSO_Two, 2
-F-4-Cl-PhCH_TwoSO_Two, 2-Br-PhCH_TwoSO_Two, 3-Br-PhCH_TwoSO_Two, Four-
Br-PhCH_TwoSO2, 2-Me-PhCH_TwoSO_Two, 3-Me-PhCH_TwoSO_Two, 4-Me-Ph
CH_TwoSO_Two, 2,4-Me_Two-PhCH_TwoSO_Two, 3,5-Me_Two-PhCH_TwoSO_Two, 2,6-Me
_Two-PhCH_TwoSO_Two, 2,3-Me_Two-PhCH_TwoSO_Two, 2,5-Me_Two-PhCH_TwoSO_Two, 2-
MeO-PhCH_TwoSO_Two, 3-MeO-PhCH_TwoSO_Two, 4-MeO-PhCH_TwoSO_Two, 2-CF
_Three-PhCH_TwoSO_Two, 3-CF_Three-PhCH_TwoSO_Two, 4-CF_Three-PhCH_TwoSO_Two, 2,4,6-
Cl_Three-PhCH_TwoSO_Two, 2,3,5-Cl_Three-PhCH_TwoSO_Two, 2,3,4-Cl_Three-PhCH_TwoS
O_Two, 2-NO_Two-PhCH_TwoSO_Two, 3-NO_Two-PhCH_TwoSO_Two, 4-NO_Two-PhCH_TwoS
O_Two, 2-CN-PhCH_TwoSO_Two, 3-CN-PhCH_TwoSO_Two, 4-CN-PhCH_TwoSO_Two, P
hCH_TwoCH_TwoSO_Two, 2-Cl-PhCH_TwoCH_TwoSO_Two, 3-Cl-PhCH_TwoCH_TwoSO_Two, 4-C
l-PhCH_TwoCH_TwoSO_Two, 2,4-Cl_Two-PhCH_TwoCH_TwoSO _Two, 3,5-Cl_Two-PhCH_TwoC
H_TwoSO_Two, 2,6-Cl_Two-PhCH_TwoCH_TwoSO_Two, 2,3-Cl_Two-PhCH_TwoCH_TwoSO_Two,
2,5-Cl _Two-PhCH_TwoCH_TwoSO_Two, 2-F-PhCH_TwoCH_TwoSO_Two, 3-F-PhCH_TwoCH_Two
SO_Two, 4-F-PhCH_TwoCH_TwoSO_Two, 2-F-4-Cl-PhCH_TwoCH_TwoSO_Two, 2-Br-P
hCH_TwoCH_TwoSO_Two, 3-Br-PhCH_TwoCH_TwoSO_Two, 4-Br-PhCH_TwoCH_TwoSO_Two, 2-
Me-PhCH_TwoCH_TwoSO_Two, 3-Me-PhCH_TwoCH_TwoSO_Two, 4-Me-PhCH_TwoCH_TwoS
O_Two, 2,4-Me_Two-PhCH_TwoCH_TwoSO_Two, 3,5-Me_Two-PhCH_TwoCH_TwoSO_Two, 2,6-M
e_Two-PhCH_TwoCH_TwoSO_Two, 2,3-Me_Two-PhCH_TwoCH_TwoSO_Two, 2,5-Me_Two-PhCH_Two
CH_TwoSO_Two, 2-MeO-PhCH_TwoCH_TwoSO_Two, 3-MeO-PhCH_TwoCH_TwoSO_Two, 4-Me
O-PhCH_TwoCH_TwoSO_Two, 2-CF_Three-PhCH_TwoCH_TwoSO_Two, 3-CF_Three-PhCH_TwoCH_TwoSO
_Two, 4-CF_Three-PhCH_TwoCH_TwoSO_Two, 2,4,6-Cl_Three-PhCH_TwoCH _TwoSO_Two, 2,3,5
-Cl_Three-PhCH_TwoCH_TwoSO_Two, 2,3,4-Cl_Three-PhCH_TwoCH_TwoSO_Two, 2-NO_Two-PhC
H_TwoCH_TwoSO_Two, 3-NO_Two-PhCH_TwoCH_TwoSO_Two, 4-NO_Two-PhCH_TwoCH_TwoSO_Two, 2-
CN-PhCH_TwoCH_TwoSO_Two, 3-CN-PhCH_TwoCH_TwoSO_Two, 4-CN-PhCH_TwoCH_TwoSO_Two,

PhCH (Me) SO_Two, 2-Cl-PhCH (Me) SO_Two, 3-Cl-Ph
CH (Me) SO_Two, 4-Cl-PhCH (Me) SO_Two, 2,4-Cl_Two-PhCH (Me) SO_Two,
3,5-Cl_Two-PhCH (Me) SO_Two, 2,6-Cl_Two-PhCH (Me) SO_Two, 2,3-Cl_Two-
PhCH (Me) SO_Two, 2,5-Cl_Two-PhCH (Me) SO_Two, 2-F-PhCH (Me) SO_Two,
 3-F-PhCH (Me) SO_Two, 4-F-PhCH (Me) SO_Two, 2-F-4-Cl-PhCH (M
e) SO_Two, 2-Br-PhCH (Me) SO_Two, 3-Br-PhCH (Me) SO_Two, 4-Br-Ph
CH (Me) SO_Two, 2-Me-PhCH (Me) SO_Two, 3-Me-PhCH (Me) SO_Two, 4-M
e-PhCH (Me) SO_Two, PhCHMeCH_TwoSO_Two, 2-Cl-PhCHMeCH_TwoSO_Two, 3-
Cl-PhCHMeCH_TwoSO_Two, 4-Cl-PhCHMeCH_TwoSO_Two, 2,4-Cl_Two-PhCHMe
CH_TwoSO_Two, 3,5-Cl_Two-PhCHMeCH_TwoSO_Two, 2,6-Cl_Two-PhCHMeCH_TwoS
O_Two, 2,3-Cl_Two-PhCHMeCH_TwoSO_Two, 2,5-Cl_Two-PhCHMeCH_TwoSO_Two, 2-
F-PhCHMeCH_TwoSO_Two, 3-F-PhCHMeCH_TwoSO_Two, 4-F-PhCHMeCH_TwoS
O_Two, 2-F-4-Cl-PhCHMeCH_TwoSO_Two, 2-Br-PhCHMeCH_TwoSO_Two, 3-Br
-PhCHMeCH_TwoSO_Two, 4-Br-PhCHMeCH_TwoSO_Two, 2-Me-PhCHMeCH_TwoS
O_Two, 3-Me-PhCHMeCH_TwoSO_Two, 4-Me-PhCHMeCH_TwoSO_Two, PhCH_TwoCH
(Me) S0_Two, 2-Cl-PhCH_TwoCH (Me) SO_Two, 3-Cl-PhCH_TwoCH (Me) SO_Two,
 4-Cl-PhCH _TwoCH (Me) SO_Two, 2,4-Cl_Two-PhCH_TwoCH (Me) SO_Two, 3,5-
Cl_Two-PhCH_TwoCH (Me) SO_Two, 2,6-Cl_Two-PhCH _TwoCH (Me) SO_Two, 2,3-Cl
_Two-PhCH_TwoCH (Me) SO_Two, 2,5-Cl_Two-PhCH_TwoCH (Me) SO_Two, 2-F-PhCH
_TwoCH (Me) SO_Two, 3-F-PhCH_TwoCH (Me) SO_Two, 4-F-PhCH_TwoCH (Me) S
O_Two, 2-F-4-Cl-PhCH_TwoCH (Me) SO_Two, 2-Br-PhCH_TwoCH (Me) SO_Two, 3
-Br-PhCH_TwoCH (Me) SO_Two, 4-Br-PhCH_TwoCH (Me) SO_Two, 2-Me-PhCH
_TwoCH (Me) SO_Two, 3-Me-PhCH_TwoCH (Me) SO_Two, 4-Me-PhCH_TwoCH (Me) S
O_Two, PhCMe_TwoSO_Two, PhCHMeCH (Me) SO_Two, PhCH_TwoCH_TwoCH_TwoSO_Two, Ph
CH_TwoCH_TwoCH_TwoCH_TwoSO_Two, PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoSO_Two, PhCH _TwoCH_TwoCH_Two
CH_TwoCH_TwoCH_TwoSO_Two,

PhSO ₂ , 2-Cl-PhSO ₂ , 3-Cl-PhSO ₂ , 4-Cl-Ph
SO ₂ , 2,4-Cl ₂ -PhSO ₂ , 3,5-Cl ₂ -PhSO ₂ , 2,6-Cl ₂ -PhSO ₂ ,
2,3-Cl ₂ -PhSO ₂ , 2,5-Cl ₂ -PhSO ₂ , 2-F-PhSO ₂ , 3-F-PhS
O ₂ , 4-F-PhSO ₂ , 2-F-4-Cl-PhSO ₂ , 2-Br-PhSO ₂ , 3-Br-Ph
SO ₂ , 4-Br-PhSO ₂ , 2-Me-PhSO ₂ , 3-Me-PhSO ₂ , 4-Me-PhSO
₂ , 2,4-Me ₂ -PhSO ₂ , 3,5-Me ₂ -PhSO ₂ , 2,6-Me ₂ -PhSO ₂ , 2,
3-Me ₂ -PhSO ₂ , 2,5-Me ₂ -PhSO ₂ , 2-MeO-PhSO ₂ , 3-MeO-PhS
O ₂ , 4-MeO-PhSO ₂ , 2-CF ₃ -PhSO ₂ , 3-CF ₃ -PhSO ₂ , 4-CF ₃ -P
hSO ₂ , 2,4,6-Cl ₃ -PhSO ₂ , 2,3,5-Cl ₃ -PhSO ₂ , 2,3,4-Cl _3-
PhSO ₂ , 2-NO ₂ -PhSO ₂ , 3-NO ₂ -PhSO ₂ , 4-NO ₂ -PhSO ₂ , 2,4-
(NO ₂ ) ₂ -PhSO ₂ , 2-CN-PhSO ₂ , 3-CN-PhSO ₂ , 4-CN-PhSO ₂ ,

CH_TwoNMe_Two, CH_TwoNEt_Two, CH_TwoN (Pr-n)_Two, CH_TwoNPR
-iso)_Two, CH_TwoN (Bu-n)_Two, CH_TwoN (Bu-iso)_Two, CH_TwoN (Bu-sec)_Two,
 CH_TwoNEtMe, CH_TwoNMePr-n, CH_TwoNMePr-iso, CH_TwoNMeBu-n, C
H_TwoNMeBu-iso, CH_TwoNMeBu-sec, CH_TwoNMeBu-tert, CH_TwoNMePe
n-n, CH_TwoNMeHex-n, CH_TwoNMeHep-n, CH_TwoNMeOct-n, CH_TwoCH_Two
NMe_Two, CH_TwoCH_TwoNEt_Two, CH_TwoCH_TwoN (Pr-n)_Two, CH_TwoCH_TwoN (Pr-is
o)_Two, CH_TwoCH_TwoN (Bu-n)_Two, CH_TwoCH_TwoN (Bu-iso)_Two, CH_TwoCH_TwoN (Bu-
sec)_Two, CH_TwoCH_TwoNEtMe, CH_TwoCH _TwoNMePr-n, CH_TwoCH_TwoNMePr-is
o, CH_TwoCH_TwoNMeBu-n, CH_TwoCH_TwoNMeBu-iso, CH_TwoCH_TwoNMeBu-se
c, CH_TwoCH_TwoNMeBu-tert, CH_TwoCH_TwoNMePen-n, CH_TwoCH_TwoNMeHex-
n, CH_TwoCH_TwoNMeHep-n, CH _TwoCH_TwoNMeOct-n,

[0040]

Embedded image

[0041]

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NMe ₂ , NEt ₂ , N (Pr-n) ₂ , N (Pr-iso) ₂ , N (Bu
-n) ₂ , N (Bu-iso) ₂ , N (Bu-sec) ₂ , NEtMe, NMePr-n, NMeP
r-iso, NMeBu-n, NMeBu-iso, NMeBu-sec, NMeBu-tert,
NMePen-n, NMeHex-n, NMeHep-n, NMeOct-n,

[0043]

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CONMe ₂ , CONEt ₂ , CON (Pr-n) ₂ , CON (Pr-is
o) ₂ , CON (Bu-n) ₂ , CON (Bu-iso) ₂ , CON (Bu-sec) ₂ , CONEt
Me, CONMePr-n, CONMePr-iso, CONMeBu-n, CONMeBu-is
o, CONMeBu-sec, CONMeBu-tert, CONMePen-n, CONMeHex
-n, CONMeHep-n, CONMeOct-n,

[0045]

Embedded image

SO ₂ NMe ₂ , SO ₂ NEt ₂ , SO ₂ N (Pr-n) ₂ , SO ₂ N (Pr
-iso) ₂ , SO ₂ N (Bu-n) ₂ , SO ₂ N (Bu-iso) ₂ , SO ₂ N (Bu-sec) ₂ ,
SO ₂ NEtMe, SO ₂ NMePr-n, SO ₂ NMePr-iso, SO ₂ NMeBu-n, S
O ₂ NMeBu-iso, SO ₂ NMeBu-sec, SO ₂ NMeBu-tert, SO ₂ NMePe
nn, SO ₂ NMeHex-n, SO ₂ NMeHep-n, SO ₂ NMeOct-n,

[0047]

Embedded image

Ph, 2-Cl-Ph, 3-Cl-Ph, 4-Cl-Ph, 2,4-Cl ₂
-Ph, 3,5-Cl ₂ -Ph, 2,6-Cl ₂ -Ph, 2,3-Cl ₂ -Ph, 2,5-Cl ₂ -P
h, 2-F-Ph, 3-F-Ph, 4-F-Ph, 2-F-4-Cl-Ph, 2-Br-Ph, 3
-Br-Ph, 4-Br-Ph, 2-Me-Ph, 3-Me-Ph, 4-Me-Ph, 2,4-Me
₂ -Ph, 3,5-Me ₂ -Ph, 2,6-Me ₂ -Ph, 2,3-Me ₂ -Ph, 2,5-Me _2-
Ph, 2-MeO-Ph, 3-MeO-Ph, 4-MeO-Ph, 2-CF ₃ -Ph, 3-CF _3-
Ph, 4-CF ₃ -Ph, 2,4,6-Cl ₃ -Ph, 2,3,5-Cl ₃ -Ph, 2,3,4-Cl
₃ -Ph, 2-NO ₂ -Ph, 3-NO ₂ -Ph, 4-NO ₂ -Ph, 2,4- (NO ₂ ) ₂ -Ph,
2-CN-Ph, 3-CN-Ph, 4-CN-Ph, 3,5- (CF ₃ ) ₂ -Ph, 4- (PhSO
₂ ) -Ph, 4- (4-Cl-Ph) -Ph, 4- (4-CF ₃ -Ph) -Ph, 1-Naph, 2-
Naph, Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8, Q9, Q10, Q1
1, Q12, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q20, Q2
1, Q22, Q23, Q24, Q25, Q26, Q27, Q28, Q29, Q30, Q3
1, Q32, Q33, Q34, Q35, Q36, Q37, Q38, Q39, Q40, Q4
1, Q42, Q43, Q44, Q45, Q46, Q47, Q48, Q49, Q50, Q5
1, Q52, Q53, Q54, Q55, Q56, Q57, Q58, Q59, Q60, Q6
1, Q62, Q63, Q64, Q65, Q66, Q67, Q68, Q69, Q70, Q7
1, Q72, Q73, Q74, Q75, Q76, Q77, Q78, Q79, Q80, Q8
1, Q82, Q83, Q84, Q85, Q86, Q87, Q88, Q89, Q90, Q9
1, Q92, Q93, Q94, Q95, Q96, Q97, Q98, Q99, Q100, Q
101, Q102, Q103, Q104, Q105, Q106, Q107, Q108, Q10
9, Q110, Q111, Q112, Q113, Q114, Q115, Q116, Q117,
Q118, Q119, Q120, Q121, Q122, Q123, Q124, Q125, Q
126, Q127, Q128, Q129, Q130, Q131, Q132, Q133, Q13
4, Q135, Q136, Q137, Q138, Q139, Q140, Q141, Q142,
Q143, Q144, Q145, Q146, Q147, Q148, Q149, Q150,

Q1-CH ₂ , Q2-CH ₂ , Q3-CH ₂ , Q4-CH ₂ , Q5-C
H ₂ , Q6-CH ₂ , Q7-CH ₂ , Q8-CH ₂ , Q9-CH ₂ , Q10-CH ₂ , Q11-CH
₂ , Q12-CH ₂ , Q13-CH ₂ , Q14-CH ₂ , Q15-CH ₂ , Q16-CH ₂ , Q1
7-CH ₂ , Q18-CH ₂ , Q19-CH ₂ , Q20-CH ₂ , Q21-CH ₂ , Q22-CH ₂ ,
Q23-CH ₂ , Q24-CH ₂ , Q25-CH ₂ , Q26-CH ₂ , Q27-CH ₂ , Q28-C
H ₂ , Q29-CH ₂ , Q30-CH ₂ , Q31-CH ₂ , Q32-CH ₂ , Q33-CH ₂ , Q3
4-CH ₂ , Q35-CH ₂ , Q36-CH ₂ , Q37-CH ₂ , Q38-CH ₂ , Q39-C
H ₂ , Q40-CH ₂ , Q41-CH ₂ , Q42-CH ₂ , Q43-CH ₂ , Q44-CH ₂ , Q4
5-CH ₂ , Q46-CH ₂ , Q47-CH ₂ , Q48-CH ₂ , Q49-CH ₂ , Q50-CH ₂ ,
Q51-CH ₂ , Q52-CH ₂ , Q53-CH ₂ , Q54-CH ₂ , Q55-CH ₂ , Q56-
CH ₂ , Q57-CH ₂ , Q58-CH ₂ , Q59-CH ₂ , Q60-CH ₂ , Q61-CH ₂ , Q
62-CH ₂ , Q63-CH ₂ , Q64-CH ₂ , Q65-CH ₂ , Q66-CH ₂ , Q67-C
H ₂ , Q68-CH ₂ , Q69-CH ₂ , Q70-CH ₂ , Q71-CH ₂ , Q72-CH ₂ , Q
73-CH ₂ , Q74-CH ₂ , Q75-CH ₂ , Q76-CH ₂ , Q77-CH ₂ , Q78-C
_{H 2, Q79-CH 2,} Q80-CH 2, Q81-CH 2, Q82-CH 2, Q83-CH 2, Q8
4-CH ₂ , Q85-CH ₂ , Q86-CH ₂ , Q87-CH ₂ , Q88-CH ₂ , Q89-C
H ₂ , Q90-CH ₂ , Q91-CH ₂ , Q92-CH ₂ , Q93-CH ₂ , Q94-CH ₂ , Q9
5-CH ₂ , Q96-CH ₂ , Q97-CH ₂ , Q98-CH ₂ , Q99-CH ₂ , Q100-C
H ₂ , Q101-CH ₂ , Q102-CH ₂ , Q103-CH ₂ , Q104-CH ₂ , Q105-C
H ₂ , Q106-CH ₂ , Q107-CH ₂ , Q108-CH ₂ , Q109-CH ₂ , Q110-C
_{H 2, Q111-CH 2,} Q112-CH 2, Q113-CH 2, Q114-CH 2, Q115-C
H ₂ , Q116-CH ₂ , Q117-CH ₂ , Q118-CH ₂ , Q119-CH ₂ , Q120-C
H ₂ , Q121-CH ₂ , Q122-CH ₂ , Q123-CH ₂ , Q124-CH ₂ , Q125-C
H ₂ , Q126-CH ₂ , Q127-CH ₂ , Q128-CH ₂ , Q129-CH ₂ , Q130-CH
_{2, Q131-CH 2, Q132} -CH 2, Q133-CH 2, Q134-CH 2, Q135-CH
_{2, Q136-CH 2, Q137} -CH 2, Q138-CH 2, Q139-CH 2, Q140-CH
₂ , Q141-CH ₂ , Q142-CH ₂ -CH ₂ , Q143-CH ₂ , Q144-CH ₂ , Q59
-O, Q60-O, Q61-O, Q62-O, Q63-O, Q64-O, Q65-O, Q66-
O, Q67-O, Q68-O, Q69-O, Q70-O, Q71-O, Q101-O, Q102
-O, Q103-O, Q104-O, Q105-O, Q106-O, Q107-O, Q108-
O, Q109-O, Q110-O, Q111-O, Q112-O, Q113-O, Q114-O,
Q115-O, Q116-O, Q117-O, Q118-O, Q59-S, Q60-S, Q61-
S, Q62-S, Q63-S, Q64-S, Q65-S, Q66-S, Q67-S, Q68-
S, Q69-S, Q70-S, Q71-S, Q101-S, Q102-S, Q103-S, Q1
04-S, Q105-S, Q106-S, Q107-S, Q108-S, Q109-S, Q110
-S, Q111-S, Q112-S, Q113-S, Q114-S, Q115-S, Q116-
S, Q117-S, Q118-S

[Substituent R of carbamoyltetrazole^Two
And R^ThreeExamples of H, Me, Et, Pr-n, Pr-iso, Bu-n, Bu-iso, Bu-sec, Bu-
tert, CHMeCHMe_Two, CH_TwoCMe = CH_Two, Pen-n, Hex-n, Hex-is
o, Pr-cyc, Bu-cyc, Pen-cyc, Hex-cyc, CH_TwoPr-cyc, CH
_TwoBu-cyc, CH_TwoPen-cyc, CH_TwoHex-cyc, CH_TwoCH_TwoPr-cyc, CH_Two
CH = CH_Two, CH_TwoCH = CHMe, CH_TwoCMe = CH_Two, CH_TwoCH_TwoCH = CH_Two, CH_TwoC
 CH, CH_TwoC CMe, CH_TwoOMe, CH_TwoOEt, CH_TwoOPr-n, CH_TwoOBu-
n, CH_TwoOBu-iso, CH_TwoOBu-sec, CH_TwoOBu-tert, CH_TwoCH_TwoOMe,
 CH_TwoCH_TwoOEt, CH_TwoCH_TwoOPr-n, CH_TwoCH_TwoCH_TwoOMe, CH_TwoCH_TwoCH_TwoOE
t, CH_TwoCH_TwoCH_TwoCH_TwoOMe, CH_TwoSMe, CH_TwoSEt, CH_TwoSPr-n, CH_TwoS
Pr-iso, CH_TwoSBu-n, CH_TwoSBu-iso, CH_TwoSBu-sec, CH_TwoSBu-t
ert, CH_TwoCH_TwoSMe, CH_TwoCH_TwoSEt, CH_TwoCH_TwoSPr-n, CH_TwoCH_TwoSPr-i
so, CH_TwoCH_TwoSBu-n, CH_TwoCH_TwoSBu-iso, CH_TwoCH_TwoSBu-sec, CH_Two
CH_TwoSBu-tert, CH_TwoCH_TwoCH_TwoSMe, CH_TwoCH_TwoCH_TwoSEt, CH_TwoCH_TwoCH_Two
SPr-n, CH_TwoCH_TwoCH_TwoSPr-iso, CH_TwoCH_TwoCH_TwoSBu-n, CH_TwoCH_TwoCH_Two
SBu-iso, CH_TwoCH_TwoCH_TwoSBu-sec, CH_TwoCH_TwoCH_TwoSBu-tert, CH_TwoC
H_TwoCl, Ph, 2-Cl-Ph, 3-Cl-Ph, 4-Cl-Ph, 2,4-Cl_Two-Ph,
3,5-Cl_Two-Ph, 2,6-Cl_Two-Ph, 2,3-Cl_Two-Ph, 2,5-Cl_Two-Ph, 2-
F-Ph, 3-F-Ph, 4-F-Ph, 2-F-4-Cl-Ph, 2-Br-Ph, 3-Br-P
h, 4-Br-Ph, 2-Me-Ph, 3-Me-Ph, 4-Me-Ph, 2,4-Me_Two-Ph,
 3,5-Me_Two-Ph, 2,6-Me_Two-Ph, 2,3-Me_Two-Ph, 2,5-Me_Two-Ph, 2
-MeO-Ph, 3-MeO-Ph, 4-MeO-Ph, 2-CF_Three-Ph, 3-CF_Three-Ph, 4-
CF_Three-Ph, 2,4,6-Cl_Three-Ph, 2,3,5-Cl _Three-Ph, 2,3,4-Cl_Three-Ph,
2-NO_Two-Ph, 3-NO_Two-Ph, 4-NO_Two-Ph, 2-CN-Ph, 3-CN-Ph, 4-
CN-Ph, CH_TwoPh, OMe, OEt, OPr-n, OPr-iso, OBu-n, OBu
-iso, OBu-sec, OBu-tert

[Substituent R ^{2 of} carbamoyltetrazole
And a specific example in which a ^3- to 9-membered ring is formed together with the nitrogen atom to which R ³ is bonded]

[0052]

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[0053]

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Carbamoyltetrazole can be easily produced by selecting any one of the following reaction formulas 1 and 2. [Reaction formula 1]

[0055]

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[Wherein R ¹ , R ² , R ³ and W have the same meaning as described above, and Z represents a halogen atom. Scheme 1 shows that carbamoyltetrazole (1a) and (1b) are obtained by reacting tetrazole (2) with carbamoyl halide (3) in the presence or absence of a base.
A method for producing

(3) is usually used in a molar amount of 1 to 10 times, preferably 1 to 2 times the molar amount of the compound (2). As the base,
Inorganic bases such as sodium hydroxide, potassium hydroxide, potassium carbonate, sodium carbonate and sodium hydride;
Organic bases such as pyridine, 4-dimethylaminopyridine, triethylamine, N, N-dimethylaniline and 1,8-diazabicyclo [5.4.0] -7-undecene (DBU), n-butyllithium and sec-butyl Organic lithiums such as lithium, and organic lithium amides such as lithium diisopropylamide and lithium bistrimethylsilylamide. The base is usually 0 to 10-fold the molar amount of (2), preferably 1 to 2 times.
Use twice as many moles.

This reaction proceeds even without solvent, but a solvent can be used if necessary. The solvent is not particularly limited as long as it is inert to the reaction. For example, aliphatic or aromatic hydrocarbons such as hexane, cyclohexane, benzene and toluene, carbon tetrachloride, chloroform and 1,2-
Halogen hydrocarbons such as dichloroethane, ethers such as diethyl ether, diisopropyl ether, dioxane and tetrahydrofuran, ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone, nitriles such as acetonitrile and propionitrile, N, N-dimethyl Acid amides such as formamide and N, N-dimethylacetamide; sulfur-containing polar solvents such as dimethylsulfoxide and sulfolane; phosphorus-containing polar solvents such as hexamethylphosphoramide and hexamethylphosphorustriamide; and pyridine and quinoline Organic bases.

The reaction temperature is usually -90 to 200 ° C, preferably 0 to 120 ° C. The reaction time is usually 0.05 to 1
00 hours, preferably 0.5 to 10 hours. In addition,
(1a) and (1b) can be separated and purified by distillation, recrystallization or chromatography. [Reaction formula 2]

[0060]

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[Wherein R ¹ , R ² , R ³ and W have the same meaning as described above. [1] is obtained by reacting a tetrazole (2) with (thio) phosgene (4) in the presence or absence of a base to give (thio)
The steps for producing carbamoyl chlorides (5a) and (5b) are shown. (4) is usually 1 to 10 for (2)
It is used in a molar amount of 0-fold, preferably 1- to 10-fold.

The solvent used in this reaction is not particularly limited as long as it is inert to the reaction. For example, hydrocarbons such as hexane, cyclohexane, benzene and toluene, carbon tetrachloride, chloroform and 1,2- Examples include halogenated hydrocarbons such as dichloroethane, and ethers such as diethyl ether, diisopropyl ether, dioxane, and tetrahydrofuran.

The reaction temperature is usually -90 to 200 ° C, preferably -20 to 120 ° C. The reaction time is usually 0.1.
It is from 05 to 100 hours, preferably from 0.5 to 10 hours. (5a) and (5b) may be used as a mixture in the next step, or may be separated and purified by distillation, recrystallization, chromatography or the like and used in the next step.

[2] shows a step of reacting (thio) carbamoyl chlorides (5a) and (5b) with amines (6) to produce carbamoyltetrazole (1a) and (1b). (6) is (5a) and (5b)
It is usually used in a molar amount of 1 to 100 times, preferably 1 to 2 times the molar amount.

This reaction proceeds without adding a base, but may be added if necessary. Examples of the base include inorganic bases such as sodium hydroxide, potassium hydroxide, potassium carbonate, sodium carbonate and sodium hydride, and organic bases such as pyridine, 4-dimethylaminopyridine, triethylamine, N, N-dimethylaniline and DBU. Kind. The bases are (5a) and (5b)
Usually from 0 to 100 times, preferably from 0 to 2 times,
Use twice as many moles.

This reaction proceeds even without solvent, but a solvent can be used if necessary. The solvent is not particularly limited as long as it is inert to the reaction, for example, hexane, cyclohexane, hydrocarbons such as benzene and toluene, carbon tetrachloride, halogenated hydrocarbons such as chloroform and 1,2-dichloroethane, Ethers such as diethyl ether, diisopropyl ether, dioxane and tetrahydrofuran; ketones such as acetone, methyl ethyl ketone and methyl isobutyl ketone; nitriles such as acetonitrile and propionitrile; N, N-dimethylformamide and N, N-dimethylacetamide Acid amides, sulfur-containing polar solvents such as dimethyl sulfoxide and sulfolane, phosphorus-containing polar solvents such as hexamethylphosphoramide and hexamethylphosphorous triamide, and pyridine and quinoline. Bases and the like.

The reaction temperature is usually -90 to 200 ° C, preferably 0 to 120 ° C. Reaction time is usually 0.05
To 100 hours, preferably 0.5 to 10 hours. Incidentally, (1a) and (1b) can be separated and purified by distillation, recrystallization or chromatography.

Examples of the synthesis of carbamoyltetrazole are specifically described below as examples, but the present invention is not limited thereto.

[0069]

【Example】

Example 1 2- (N, N-diethylcarbamoyl) -5-methyltetrazole (Compound No. 1a-8) and 1- (N,
Synthesis of N-diethylcarbamoyl) -5-methyltetrazole (Compound No. 1b-8)

[0070]

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5-Methyltetrazole (6.0 g, 71 mmol) was dissolved in pyridine (14 ml), and N, N-diethylcarbamoyl chloride (9.7 g, 7
2 mmol) was added. After stirring at room temperature for 16 hours, diethyl ether (50 ml) was added, and the insoluble matter was removed by filtration.
The obtained diethyl ether solution was washed with dilute hydrochloric acid and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and the solvent was distilled off. The obtained residue was separated and purified by silica gel column chromatography (eluent: n-hexane / ethyl acetate = 1/1) to give 2- (N, N-diethylcarbamoyl) -5-methyltetrazole and 1-methyltetrazole.
4.5 g (oil) and 2.7 g (oil) of (N, N-diethylcarbamoyl) -5-methyltetrazole were obtained.

Example 2 2- (N, N-dimethylthiocarbamoyl) -5-methyltetrazole (compound No. 1a-34) and 1-
Synthesis of (N, N-dimethylthiocarbamoyl) -5-methyltetrazole (Compound No. 1b-14)

[0073]

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5-Methyltetrazole (0.5 g, 5.9 mmol) was dissolved in pyridine (2 ml), and N, N-dimethylthiocarbamoyl chloride (0.73
g, 5.9 mmol). After stirring at room temperature for 16 hours, diethyl ether (15 ml) was added, and the insolubles were removed by filtration. The obtained diethyl ether solution was washed with dilute hydrochloric acid and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and the solvent was distilled off. The obtained residue is subjected to silica gel column chromatography (eluent: n-hexane /
Separation and purification were performed using ethyl acetate = 1/1) to give 2- (N, N-
Dimethylthiocarbamoyl) -5-methyltetrazole and 1- (N, N-dimethylthiocarbamoyl) -5
0.11 g (oil) and 0.23 g (oil) of -methyltetrazole were obtained, respectively.

Tables 1 and 2 show the structural formulas and physical properties of the compounds synthesized by using the same method as in the above examples. However, the symbols in the table have the following meanings.

[0076]

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[Table 1]

[0078]

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[0079]

[Table 1] Ｎｏ No. R ¹ W -NR ² R ³ Physical properties (melting point, ° C) ─────────────────────────────────── ─ 1a-1 MeS O A ¹ Oily substance 1a-2 Ph O A ¹ 35-37 1a-3 MeS O A ² Oily substance 1a-4 MeS O A ³ oil ^{1a-5 MeS O A 4 33-36} 1a-6 EtS O A 1 oil 1a-7 MeS O A ⁵ oil 1a-8 Me O A ¹ oil 1a-9 MeS O A ⁶ oil Substance 1a-10 2-Cl-Ph O A ¹ 43-46 1a-11 Ph O A ² Oily substance 1a-12 MeS O A ⁷ Oil 1a-13 Ph O A ³ 71-72 1a-14 Ph O A ⁴ 100-101 1a-15 Ph O A ⁸ 93-94 1a-16 4-Me-Ph O A ¹ 63-64 1a-17 2-Naph O A ¹ Oil 1a-18 1-Naph O A ¹ oil _{1a-19 CO 2 Et O A} 1 oil ^{1a-20 Q101 O A 1 112-113} 1a-21 Q102 O A 1 82-86 1a-22 Q104 O A 1 oil 1a-23 4-CF ₃ - Ph O A ¹ 74-75 ────────────────────────────────────

[0080]

[Table 2] Ｎｏ No. R ¹ W -NR ² R ³ Physical properties (melting point, ° C) ─────────────────────────────────── ─ 1a-24 4-Cl- PhCH 2 O A 1 oil 1a-25 Q149 O A ¹ oil 1a-26 4 over PhO-Ph O A ¹ oil 1a-27 Q61 O A ¹ oil 1a-28 4 ^{_{-NO 2 -Ph O A 1 109-112 1a}} -29 Me O A 3 oil ^{1a-30 Q105 O A 1 105-106} 1a-31 Q150 O A 1 oil 1a-32 Et O A ¹ oil 1a- 33 MeS O A ⁹ Oil 1a-34 MeS A ³ Oil 1a-35 PhCH ₂ SO A ¹ Oil 1a-36 (Pr-n) SO A ¹ Oil 1a-37 2-Cl-Ph O A ¹ oil 1a-38 Pr-n O A 1 oil 1a-39 Pr-iso O A 1 oil 1a-40 Bu-tert O A 1 oil _{1a-41 4- (PhSO 2)} -Ph O A 1 121 _{-122 1a-42 CF 3 O A} 1 oil Material _{1a-43 CMe = CH 2 O} A 1 oil 1a-44 Q99 O A ¹ oil 1a-45 Q97 O A ¹ oil _{1a-46 CH = CH 2 O} A 1 oil ─────── ─────────────────────────────

[0081]

[Table 3] ──────────────────────────────────── No. R ¹ W -NR ² R ³ Physical properties (melting point, ° C) ─────────────────────────────────── ─ 1a-47 Q146 O A ¹ oil _{1a-48 4-CF 3 O} -Ph O A 1 oil 1a-49 Q2 O A ¹ oil _{1a-50 3-CF 3 -Ph} O A 1 oil 1a- 51 3,5- (CF ₃ ) ₂ -Ph O A ¹ Oil 1a-52 4- (4-Cl-Ph) -Ph O A ¹ 114-115 1a-53 4- (4-CF ₃ -Ph) -Ph O A ¹ 126-127 ────────────────────────────────────

[Table 2]

[0083]

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[0084]

[Table 4] No. R ¹ W -NR ² R ³ Physical properties (melting point, ° C) ─────────────────────────────────── ─ 1b-1 MeS O A ¹ 40-41 1b-2 MeS O A ² Oily substance 1b-3 MeS O A ³ 67-69 1b-4 MeS ^{O A 4 74-76 1b-5 EtS} O A 1 oil ^{1b-6 MeS O A 5 79-81} 1b-7 MeS O A 9 84-86 1b-8 Me O A 1 oil 1b-9 MeS O A ⁶ oil ^{1b-10 MeS O A 8 65-67} 1b-11 MeS O A 7 oil ^{1b-12 Me O A 3 62-66} 1b-13 Et O A 1 oil 1b-14 Me S A ³ oil 1b-15 PhCH ₂ SO A ¹ oil 1b-16 (Pr-n) SO A 1 oil 1b-17 Pr-n O A 1 oil 1b-18 Pr-iso O A 1 60-61 1b-19 HO A ⁶ 53-54 1b-20 CH = CH ₂ O A ¹ oily substance ───────────────────────────────── ───

¹ H of the compounds shown in Tables 1 and 2
The results of NMR measurement (23.5 ° C., 400 MHz) are shown in Tables 3 and 4. [Table 3]

[0086]

[Table 5] ──────────────────────────────────── No. ¹ H NMR (solvent δ (ppm)) ──────────────────────────────────── 1a-1 CDCl ₃ 1.22-1.42 (m, 6H), 2.76 (s, 3H), 3.28-3.45 (m, 2H), 3.53-3.69 (m, 2H) 1a-2 CDCl 3 1.35 (t J = 6.8Hz, 6H), 3.00 -3.90 (m, 4H), 7.20-8.45 (m, 5H) 1a-3 CDCl ₃ 1.30 (br s, 6H), 1.50 (br s, 6H), 2.73 (s, 3H), 3.70 (br s, 2H ) 1a-4 CDCl ₃ 2.73 (s, 3H), 3.14 (s, 3H), 3.27 (s, 3H) 1a-5 CDCl ₃ 2.02-2.05 (m, 4H), 2.73 (s, 3H), 3.75-3.82 (m, 4H) 1a-6 CDCl ₃ 1.29-1.35 (m, 6H), 1.46 (t J = 7.4Hz, 3H), 3.77 (q J = 7.4Hz, 2H), 3.33-3.39 (m, 2H), 3.54-3.68 (m, 2H) 1a-7 CDCl ₃ 1.64-1.84 (m, 6H), 2.73 (s, 3H), 3.43 (br s, 2H), 3.77 (br s, 2H) 1a-8 CDCl ₃ 1.28 (br s, 3H), 1.33 (br s, 3H), 2.63 (s, 3H), 3.37 (br s, 2H), 3.62 (br s, 2H) 1a-9 CDCl ₃ 1.09-1.38 (m, 6H) , 2.42 (s, 3H), 4.81 (br s, 1H), 7.10-7.40 (m, 5H) 1a-10 CDCl ₃ 1.33 (t J = 7.0Hz, 3H), 1.38 (t J = 7.0Hz, 3H) , 3.40 (q J = 7.0Hz, 2H), 3.65 (q J = 7.0Hz, 2H), 7.49 (d J = 8.7Hz, 2H), 8.16 (d J = 8.7H z, 2H) 1a-11 CDCl ₃ 1.31 (br s, 6H), 1.57 (br s, 6H), 3.66-3.78 (m, 1H), 7.48-7.54 (m, 3H), 8.20-8.25 (m, 2H ) 1a-12 CDCl ₃ 1.61-1.73 (m, 4H), 1.76-1.83 (m, 2H), 1.88-1.96 (m, 2H), 2.73 (s, 3H), 3.46 (t J = 6.0Hz, 2H) , 3.75 (t J = 6.0Hz, 2H) ────────────────────────────────────

[0087]

[Table 6] Ｎｏ No. NMR (solvent δ (ppm)) １ 1a-13 CDCl ₃ 3.17 (s, 3H), 3.30 (s, 3H), 7.50-7.52 (m, 3H), 8.22-8.24 (m, 2H) 1a-14 CDCl ₃ 2.01-2.09 (m, 4H), 3.81 (t J = 6.4 Hz, 2H), 3.87 (t J = 6.5Hz, 2H), 7.50-7.52 (m, 3H), 8.23-8.25 (m, 2H) 1a-15 CDCl ₃ 3.63 (s, 3H), 7.17-7.31 (m , 5H), 7.42-7.45 (m, 3H), 8.03-8.05 (m, 2H) 1a-16 CDCl 3 1.32 (t J = 6.9Hz, 3H), 1.38 (t J = 6.9Hz, 3H), 2.43 ( s, 3H), 3.40 (q J = 6.9Hz, 2H), 3.64 (q J = 6.9Hz, 2H), 7.32 (d J = 8.1Hz, 2H), 8.11 (d J = 8.1Hz, 2H) 1a- 17 CDCl ₃ 1.31 (t J = 6.9Hz, 3H), 1.36 (t J = 6.9Hz, 3H), 3.38 (q J = 6.9Hz, 2H), 3.62 (q J = 6.9Hz, 2H), 7.48-7.55 (m, 2H), 7.81-7.88 (m, 1H), 7.90-7.96 (m, 2H), 8.23 (d J = 8.6Hz, 1H), 8.76 (s, 1H) 1a-18 CDCl ₃ 1.33 (t J = 7.0Hz, 3H), 1.38 (t J = 7.0Hz, 3H), 3.41 (q J = 7.0Hz, 2H), 3.65 (q J = 7.0Hz, 2H), 7.53-7.64 (m, 3H), 7.90 -8.01 (m, 2H), 8.38 (d J = 7.2Hz, 1H), 8.97 (d J = 8.6Hz, 1H) 1a-19 CDCl ₃ 1.27 (t J = 7.1Hz, 3H), 1.38 (t J = 7.1Hz , 3H), 1.48 (t J = 7.1Hz, 3H), 3.29 (q J = 7.1Hz, 2H), 3.66 (q J = 7.1Hz, 2H), 4.56 (q J = 7.1Hz, 2H) ─── ─────────────────────────────────

[0088]

[Table 7] ──────────────────────────────────── No. NMR (solvent δ (ppm)) １ 1a-20 CDCl ₃ 1.31 (t J = 6.9Hz, 3H), 1.39 (t J = 6.9Hz, 3H), 3.37 (q J = 6.9Hz, 2H), 3.67 (q J = 6.9Hz, 2H), 7.63 (dd J = 7.3, 7.7Hz, 1H), 7.80 (dd J = 7.3,8.0Hz, 1H), 7.89 (d J = 8.0Hz, 1H), 8.33 (d J = 7.7Hz, 1H), 8.36 (s, 2H) 1a-21 CDCl ₃ 1.37 (t J = 7.0Hz, 3H), 1.41 (t J = 7.0Hz, 3H), 3.44 (q J = 7.0Hz, 2H), 3.68 (q J = 7.0Hz, 2H), 7.63 (dd J = 7.1,8.0Hz, 1H), 7.80 (dd J = 7.1,8.4Hz, 1H), 7.94 (d J = 8.0Hz, 1H), 8.17 (d J = 8.4Hz, 1H), 9.01 (s, 1H) , 9.69 (s, 1H) 1a-22 CDCl ₃ 1.31 (t J = 6.9Hz, 3H), 1.39 (t J = 6.8Hz, 3H), 3.40 (q J = 6.9Hz, 2H), 3.68 (q J = 6.8Hz, 2H), 7.66-7.78 (m, 2H), 7.82 (d J = 5.6Hz, 1H), 7.91 (d J = 8.2Hz, 1H), 8.75 (d J = 5.6Hz, 1H), 9.02 ( d J = 8.2Hz, 1H) 1a-23 CDCl ₃ 1.34 (t J = 6.8Hz, 3H), 1.40 (t J = 6.9Hz, 3H), 3.40 (q J = 6.8Hz, 2H), 3.66 (q J = 6.9Hz, 2H), 7.79 (d J = 8.2Hz, 2H), 8.36 (d J = 8.2Hz, 2H) 1a-24 CDCl ₃ 1.24 (t J = 7.1Hz, 3H), 1.33 (t J = 7.1 Hz, 3H), 3.29 (q J = 7.1Hz, 2H), 3.59 (q J = 7.1Hz, 2H), 4.29 (s, 2H), 7.28 (s, 4H) 1a-25 CDCl ₃ 1.32 (br s, 6H), 3.42 (br s, 4H), 3.54-3.62 (m, 4H) , 3.81-3.86 (m, 4H) ────────────────────────────────────

[0089]

[Table 8] Ｎｏ No. NMR (solvent δ (ppm)) １ 1a-26 CDCl ₃ 1.32 (t J = 6.9Hz, 3H), 1.38 (t J = 6.9Hz, 3H), 3.39 (q J = 6.9Hz, 2H), 3.64 (q J = 6.9Hz, 2H), 7.06-7.21 (m, 5H ), 7.36-7.42 (m, 2H), 8.17-8.21 (m, 2H) 1a-27 CDCl ₃ 1.35 (t J = 6.5Hz, 3H), 1.40 (t J = 6.8Hz, 3H), 3.40 (q J = 6.5Hz, 2H), 3.68 (q J = 6.8Hz, 2H), 8.09-8.11 (m, 2H), 8.81-8.83 (m, 2H) 1a-28 CDCl ₃ 1.35 (t J = 7.0Hz, 3H) , 1.41 (t J = 7.0Hz, 3H), 3.41 (q J = 7.0Hz, 2H), 3.68 (q J = 7.0Hz, 2H), 8.37-8.46 (m, 4H) 1a-29 CDCl ₃ 2.72 (s , 3H), 3.16 (s, 3H), 3.24 (s, 3H) 1a-30 CDCl ₃ 1.30 (t J = 6.8 Hz, 3H), 1.39 (t J = 6.8 Hz, 3H), 3.41 (q J = 6.8 Hz, 2H), 3.68 (q J = 6.8Hz, 2H), 7.70-8.09 (m, 4H), 8.72 (s, 1H), 9.43 (s, 1H) 1a-31 CDCl ₃ 1.32 (t J = 6.6Hz , 3H), 1.37 (t J = 6.6Hz, 3H), 3.39 (q J = 6.6Hz, 2H), 3.64 (q J = 6.6Hz, 2H), 6.05 (s, 2H), 6.91 (d J = 8.1 Hz, 1H), 7.63 (s, 1H), 7.77 (d J = 8.1Hz, 1H) 1a-32 CDCl ₃ 1.27 (t J = 6.6Hz, 3H), 1.36 (t J = 6.6Hz, 3H), 1.43 (q J = 7.7H z, 3H), 3.01 (q J = 7.7Hz, 2H), 3.36 (q J = 6.6Hz, 2H), 3.63 (q J = 6.6Hz, 2H), 1a-33 CDCl ₃ 2.71 (s, 3H), 3.56-3.92 (m, 8H) 1a-34 CDCl ₃ 2.63 (s, 3H), 3.14 (s, 3H), 3.62 (s, 3H) ───────────────── ───────────────────

[0090]

[Table 9] ──────────────────────────────────── No. NMR (solvent δ (ppm)) １ 1a-35 CDCl ₃ 1.23 (t J = 6.7Hz, 3H), 1.34 (t J = 6.7Hz, 3H), 3.29 (q J = 6.7Hz, 2H), 3.60 (q J = 6.7Hz, 2H), 4.48 (s, 2H), 7.26-7.43 (m, 5H) 1a-36 CDCl ₃ 1.06 (t J = 7.3Hz, 3H), 1.29 (t J = 6.8Hz, 3H), 1.35 (t J = 6.8Hz, 3H), 1.76-1.86 ( m, 2H), 3.23 (t J = 7.2Hz, 2H), 3.35 (q J = 6.8Hz, 2H), 3.61 (q J = 6.8Hz, 2H) 1a-37 CDCl ₃ 1.33 (t J = 7.0Hz, 3H), 1.34 (t J = 7.0Hz, 3H), 3.42 (q J = 7.0Hz, 2H), 3.65 (q J = 7.0Hz, 2H), 7.41-7.48 (m, 2H), 7.56-7.58 (m , 1H), 8.05-8.07 (m, 1H) 1a-38 CDCl ₃ 1.02 (t J = 7.4Hz, 3H), 1.28 (t J = 6.8Hz, 3H), 1.36 (t J = 6.8Hz, 3H), 1.82-1.92 (m, 2H), 2.95 (t J = 7.2Hz, 2H), 3.35 (q J = 6.8Hz, 2H), 3.61 (q J = 6.8Hz, 2H) 1a-39 CDCl ₃ 1.28 (t J = 6.6Hz, 3H), 1.35 (t J = 6.6Hz, 3H), 1.44 (d J = 6.9Hz, 6H), 3.27-3.38 (m, 2H), 3.33 (q J = 6.6Hz, 2H), 3.61 (q J = 6.6Hz, 2H) 1a-40 CDCl ₃ 1.34 (br s, 3H), 1.46 (br s, 3H), 1.56 (br s, 9H), 3.20-3.39 (m, 2H), 3.50-3.68 (m, 2H) 1a- 41 CDCl ₃ 1.31 (t J = 6.8Hz, 3H), 1.39 (t J = 6.8Hz, 3H), 3.37 (q J = 6.8Hz, 2H), 3.65 (q J = 6.8Hz, 2H), 7.50-7.66 (m, 3H), 7.99 (d J = 7.3Hz, 2H), 8.10 (d J = 8.4Hz, 2H), 8.37 (d J = 8.4Hz, 2H) ──────────── ────────────────────────

[0091]

[Table 10] ──────────────────────────────────── No. NMR (solvent δ (ppm)) １ 1a-42 CDCl ₃ 1.30 (t J = 7.1Hz, 3H), 1.39 (t J = 7.1Hz, 3H), 3.30 (q J = 7.1Hz, 2H), 3.66 (q J = 7.1Hz, 2H) 1a-43 CDCl ₃ 1.30 (t J = 6.9Hz, 3H), 1.37 (t J = 6.9Hz, 3H), 2.27 (s, 3H), 3.36 (q J = 6.9Hz, 2H), 3.62 (q J = 6.9Hz, 2H), 5.53 ( s, 1H), 6.31 (s, 1H) 1a-44 CDCl ₃ 1.35 (t J = 7.0Hz, 3H), 1.39 (t J = 7.0Hz, 3H), 3.40 (q J = 7.0Hz, 2H), 3.66 (q J = 7.0Hz, 2H), 3.95 (s, 3H) 1a-45 CDCl ₃ 1.33 (t J = 7.2Hz, 3H), 1.38 (t J = 7.2Hz, 3H), 3.38 (q J = 7.2Hz , 2H), 3.64 (q J = 7.2 Hz, 2H), 3.96 (s, 3H), 8.18 (s, 1H) 1a-46 CDCl ₃ 1.29 (t J = 6.8 Hz, 3H), 1.36 (t J = 6.8 Hz, 3H), 3.37 (q J = 6.8Hz, 2H), 3.63 (q J = 6.8Hz, 2H), 5.80 (d J = 11.2Hz, 1H), 6.53 (d J = 17.8Hz, 1H), 6.88 (dd J = 11.2Hz, 17.8Hz, 1H) 1a-47 CDCl ₃ 1.28 (t J = 7.0Hz, 3H), 1.36 (t J = 7.0Hz, 3H), 1.90 (s, 3H), 3.14 (d J = 5.4Hz, 1H), 3.31 (q J = 7.0Hz, 2H), 3.58 (d J = 5.4Hz, 1H), 3.63 (q J = 7.0Hz, 2H) 1a-48 CDCl ₃ 1.34 (t J = 7.1 Hz, 3H), 1 .39 (t J = 7.1Hz, 3H), 3.42 (q J = 7.1Hz, 2H), 3.67 (q J = 7.1Hz, 2H) 7.34 (d J = 8.0Hz, 2H), 8.28 (d J = 8.0 Hz, 2H) ────────────────────────────────────

[0092]

[Table 11] ──────────────────────────────────── No. NMR (solvent δ (ppm)) ──────────────────────────────────── 1a-49 CDCl ₃ 1.30 (t J = 6.4Hz, 3H), 1.36 (t J = 6.4Hz, 3H), 3.38 (q J = 6.4Hz, 2H), 3.63 (q J = 6.4Hz, 2H), 7.52-7.54 (m, 1H ), 7.72-7.80 (m, 1H), 8.16-8.22 (m, 1H) 1a-50 CDCl ₃ 1.35 (t J = 6.6 Hz, 3H), 1.41 (t J = 6.6 Hz, 3H), 3.43 (q J = 6.6Hz, 2H), 3.68 (q J = 6.6Hz, 2H), 7.64-7.72 (m, 1H), 7.74-7.80 (m, 1H), 8.39-8.46 (m, 1H), 8.48-8.53 (m , 1H) 1a-51 CDCl ₃ 1.36 (t J = 7.0 Hz, 3H), 1.42 (t J = 7.0 Hz, 3H), 3.44 (q J = 7.0 Hz, 2H), 3.75 (q J = 7.0 Hz, 2H ), 8.03 (s, 1H), 8.72 (s, 2H) 1a-52 CDCl ₃ 1.25-1.50 (m, 6H), 3.35-3.79 (m, 4H), 7.44 (br s, 2H), 7.58 (br s , 2H), 7.70 (Br s, 2H), 8.27 (br s, 2H) 1a-53 CDCl ₃ 1.35 (t J = 6.6 Hz, 3H), 1.40 (t J = 6.6 Hz, 3H), 3.42 (q J = 6.6Hz, 2H), 3.67 (q J = 6.6Hz, 2H), 7.72-7.78 (m, 6H), 8.33 (s, 1H), 8.35 (s, 1H) ────────── ──────────────────────────

[Table 4]

[0094]

[Table 12] Ｎｏ No. NMR (solvent δ (ppm)) １ 1b-1 CDCl ₃ 1.33 (t J = 7.2Hz, 6H), 2.77 (S, 3H), 3.56 (q J = 7.2Hz, 4H) 1b-2 CDCl ₃ 1.41 (br s, 12H), 2.79 (s, 3H), 3.90 (br s, 2H) 1b-3 CDCl ₃ 2.77 (s, 3H), 3.21 (s, 3H), 3.29 (s, 3H) 1b-4 CDCl ₃ 2.00-2.06 (m, 4H), 2.75 (s, 3H), 3.71 (t J = 6.5Hz, 2H), 3.95 (t J = 6.5Hz, 2H) 1b-5 CDCl ₃ 1.32 (t J = 7.0Hz, 6H), 1.49 (t J = 7.4Hz, 3H), 3.35 ( q J = 7.4Hz, 2H), 3.55 (q J = 7.0Hz, 4H) 1b-6 CDCl ₃ 1.74 (s, 6H), 2.78 (s, 3H), 3.69 (br s, 4H) 1b-7 CDCl ₃ 2.77 (s, 3H), 3.83 (br s, 4H) 1b-8 CDCl ₃ 1.27-1.39 (m, 6H), 2.71 (s, 3H), 3.34-3.45 (m, 2H), 3.56-3.66 (m, 2H) 1b-9 CDCl ₃ 1.29 (d J = 6.8 Hz, 6H), 2.72 (s, 3H), 4.76-4.82 (m, 1H), 7.10-7.13 (m, 2H), 7.30-7.33 (m, 3H ) 1b-10 CDCl ₃ 2.75 (s, 3H), 3.56 (s, 3H), 7.13-7.28 (m, 2H), 7.30-7.37 (m, 3H) 1b-11 CDCl ₃ 1.67 (br s, 4H), 1.77-1.96 (m, 4H), 2.78 (s, 3H), 3.66-3.75 (m, 4H) 1b-12 CDCl ₃ 2 .63 (s, 3H), 3.14 (s, 3H), 3.27 (s, 3H) 1b-13 CDCl ₃ 1.28 (t J = 7.1Hz, 3H), 1.34 (t J = 7.1Hz, 3H), 1.41 ( t J = 7.6Hz, 3H), 3.08 (q J = 7.6Hz, 2H), 3.34 (q J = 7.1Hz, 2H), 3.59 (q J = 7.1Hz, 2H) 1b-14 CDCl ₃ 2.72 (s, 3H), 3.13 (s, 3H), 3.62 (s, 3H) ────────────────────────────────── ──

[0095]

[Table 13] ──────────────────────────────────── No. NMR (solvent δ (ppm)) ──────────────────────────────────── 1b-15 CDCl ₃ 1.29 (t J = 7.2Hz, 6H), 3.51 (q J = 7.2Hz, 4H), 4.56 (s, 2H), 7.26-7.46 (m, 5H) 1b-16 CDCl ₃ 1.08 (t J = 7.4Hz, 3H ), 1.30-1.35 (m, 6H) , 1.81-1.91 (m, 2H), 3.30-3.36 (m, 2H), 3.50-3.60 (m, 4H) 1b-17 CDCl 3 1.02 (t J = 7.4Hz, 3H), 1.28 (t J = 7.1Hz, 3H), 1.34 (t J = 7.1Hz, 3H), 1.82-1.89 (m, 2H), 3.03 (t J = 7.6Hz, 2H), 3.32 (q J = 7.1Hz, 2H), 3.59 (q J = 7.1Hz, 2H) 1b-18 CDCl ₃ 1.27 (t J = 7.1Hz, 3H), 1.34 (t J = 7.1Hz, 3H), 1.42 (d J = 7.2Hz , 6H), 3.28 (q J = 7.1Hz, 2H), 3.44-3.55 (m, 1H), 3.60 (q J = 7.1Hz, 2H) 1b-19 CDCl ₃ 1.29 (d J = 6.8Hz, 6H), 4.79-4.90 (m, 1H), 7.12-7.17 (m, 2H), 7.33-7.38 (m, 3H), 8.92 (br s, 1H) 1b-20 CDCl ₃ 1.28 (t J = 7.1Hz, 3H), 1.35 (t J = 7.1Hz, 3H), 3.32 (q J = 7.1Hz, 2H), 3.61 (q J = 7.1Hz, 2H), 5.95 (d J = 11.3Hz, 1H), 6.62 (d J = 17.5 Hz, 1H), 6.91 (dd J = 11.3Hz, 17.5Hz, 1H) ─────────────────────── ────────────

Next, examples of the compounds included in the present invention, including the compounds synthesized in the above Examples, are shown below, but are not particularly limited thereto.

[0097]

Embedded image

[0098]

Embedded image

However, in the above formula, R¹Indicates the following. H, Me, Et, Pr-n, Pr-iso, Bu-n, Bu-iso, Bu-sec, Bu-
tert, Pen-n, Et_TwoCH, Hex-n, Hep-n, Oct-n, Me (Pr-n) C
H, Me (Bu-n) CH, Et (Pr-n) CH, Et (Bu-n) CH, (Pr-n)_TwoCH,
Me (Pen-n) CH, Et (Pen-n) CH, (Pr-n) (Bu-n) CH, Me_TwoCHCH_Two
CH_Two, Pr-cyc, Bu-cyc, Pen-cyc, Hex-cyc, CH_TwoPr-cyc,
CH_TwoBu-cyc, CH_TwoPen-cyc, CH_TwoHex-cyc, CH_TwoCH_TwoPr-cyc, C
H_TwoCH = CH_Two, CH_TwoCH = CHMe, CH_TwoCH = CHEt, CH_TwoCMe = CH_Two, CH_TwoC
H_TwoCH = CH_Two, CH_TwoCH_TwoCH = CHMe, CH_TwoCH = CMe_Two, CHMeCH = CH_Two, CH
_TwoCMe = CHMe, CHMeCH = CHMe, CH_TwoCMe = CHEt, CH_TwoCH_TwoCH = CM
e_Two, CH_TwoCMe = CMe_Two, CH_TwoC CH, CH_TwoC CMe, CH_TwoC CEt, C
H_TwoCH_TwoC CH, CH_TwoCH_TwoC CMe, CHMeC CH, CHMeC CMe, C
H_TwoOMe, CH_TwoOEt, CH_TwoOPr-n, CH _TwoOPr-iso, CH_TwoOBu-n, CH_Two
OBu-iso, CH_TwoOBu-sec, CH_TwoOBu-tert, CH_TwoCH_TwoOMe, CH_TwoCH
_TwoOEt, CH_TwoCH_TwoOPr-n, CH_TwoCH_TwoCH_TwoOMe, CH_TwoCH_TwoCH_TwoOEt, CH_Two
CH_TwoCH_TwoCH_TwoOMe, CH_TwoOCH_TwoCH = CH_Two, CH_TwoOCH_TwoCH = CHMe, CH_TwoCH
_TwoOCH_TwoCH = CH_Two, CH_TwoCH_TwoOCH_TwoCH = CHMe, CH_TwoOCH_TwoC CH, CH_TwoO
CH_TwoC CMe, CH_TwoOCHMeC CH, CH_TwoOCMe_TwoC CH, CH_TwoCH_TwoOCH
_TwoC CH, CH_TwoCH_TwoOCH_TwoC CMe, CH_TwoCH_TwoOCHMeC CH, CH_TwoCH_Two
OCMe_TwoC CH,

CH ₂ OCHF ₂ , CH ₂ OCF ₃ , CH ₂ OCF ₂ CF ₃ , CH ₂ CH ₂ O
CHF ₂ , CH ₂ CH ₂ OCF ₃ , CH ₂ CH ₂ OCF ₂ CF ₃ , CH ₂ OCH ₂ CF ₃ , CH ₂ CH
₂ OCH ₂ CF ₃ , CH ₂ OCH ₂ CHF ₂ , CH ₂ CH ₂ OCH ₂ CHF ₂ , CH ₂ OCH ₂ CH
₂ F, CH ₂ OCH ₂ CH ₂ Cl, CH ₂ OCH ₂ CH ₂ Br, CH ₂ CH ₂ OCH ₂ CH ₂ F, CH
₂ CH ₂ OCH ₂ CH ₂ Cl, CH ₂ CH ₂ OCH ₂ CH ₂ Br, CH ₂ OCH ₂ CH = CHCl, CH
₂ CH ₂ OCH ₂ CH = CHCl, CH ₂ OCH ₂ CH = CHBr, CH ₂ CH ₂ OCH ₂ CH = CHB
r, CH ₂ OCH ₂ CF = CF ₂ , CH ₂ CH ₂ OCH ₂ CF = CF ₂ , CH ₂ OCH = CHCl, CH
₂ CH ₂ OCH = CHCl, CH ₂ OCF = CF ₂ , CH ₂ CH ₂ OCF = CF ₂ , CH ₂ OCF ₂ CF
= CF ₂ , CH ₂ CH ₂ OCF ₂ CF = CF ₂ , CH ₂ OCH ₂ CH = CF ₂ , CH ₂ CH ₂ OCH ₂ C
H = CF ₂ , CH ₂ OCH ₂ CH = CHCF ₃ , CH ₂ CH ₂ OCH ₂ CH = CHCF ₃ , CH ₂ OCH
₂ C CI, CH ₂ OCH ₂ CH ₂ C CI, CH ₂ CH ₂ OCH ₂ C CI, CH ₂ OCH ₂ C
CCF ₃ , CH ₂ CH ₂ OCH ₂ C CCF ₃ , CH ₂ OCMe ₂ C CI, CH ₂ CH ₂ OC
Me ₂ C CI, CH ₂ OCMe ₂ C CCF ₃ , CH ₂ CH ₂ OCMe ₂ C CCF ₃ ,

CH_TwoSMe, CH_TwoSEt, CH_TwoSPr-n, CH_TwoSPr-iso,
CH_TwoSBu-n, CH_TwoSBu-iso, CH_TwoSBu-sec, CH_TwoSBu-tert, CH_TwoC
H_TwoSMe, CH_TwoCH_TwoSEt, CH_TwoCH_TwoSPr-n, CH_TwoCH_TwoSPr-iso, CH_TwoC
H_TwoSBu-n, CH_TwoCH_TwoSBu-iso, CH_TwoCH_TwoSBu-sec, CH_TwoCH_TwoSBu-t
ert, CH_TwoCH_TwoCH_TwoSMe, CH_TwoCH_TwoCH _TwoSEt, CH_TwoCH_TwoCH_TwoSPr-n, C
H_TwoCH_TwoCH_TwoSPr-iso, CH_TwoCH_TwoCH_TwoSBu-n, CH_TwoCH_TwoCH_TwoSBu-iso,
 CH_TwoCH_TwoCH_TwoSBu-sec, CH_TwoCH_TwoCH_TwoSBu-tert, CH_TwoS (O) Me, C
H_TwoS (O) Et, CH_TwoS (O) Pr-n, CH_TwoS (O) Pr-iso, CH_TwoS (O) Bu-n,
 CH_TwoS (O) Bu-iso, CH_TwoS (O) Bu-sec, CH_TwoS (O) Bu-tert, CH_Two
CH_TwoS (O) Me, CH_TwoCH_TwoS (O) Et, CH_TwoCH_TwoS (O) Pr-n, CH_TwoCH_TwoS
(O) Pr-iso, CH_TwoSO_TwoMe, CH_TwoSO_TwoEt, CH_TwoSO_TwoPr-n, CH_TwoSO_TwoP
r-iso, CH_TwoSO_TwoBu-n, CH_TwoSO_TwoBu-iso, CH_TwoSO_TwoBu-sec, CH_Two
SO_TwoBu-tert, CH_TwoCH_TwoSO_TwoMe, CH_TwoCH_TwoSO_TwoEt, CH_TwoCH_TwoSO_TwoPr-
n, CH_TwoCH_TwoSO _TwoPr-iso,

CH ₂ F, CH ₂ Cl, CH ₂ Br, CH ₂ I, CHF ₂ , CHCl ₂ ,
_{CHBr 2, CF 3, CCl 3} , CBr 3, CClF 2, CBrF 2, CH 2 FCH 2, CH
F ₂ CH ₂ , CF ₃ CH ₂ , CF ₃ CF ₂ , CF ₃ CF ₂ CF ₂ , ClCH ₂ CH ₂ , BrCH ₂ C
H ₂ , CCl ₃ CH ₂ , CF ₃ CH ₂ CH ₂ , CCl ₃ CH ₂ CH ₂ , ClCH ₂ CH ₂ CH ₂ , F
CH ₂ CH ₂ CH ₂ , CF ₃ CF ₂ CH ₂ , ClCH ₂ CH ₂ CH ₂ CH ₂ , CH ₂ CH = CHCl,
CH ₂ CH = CHBr, CH ₂ CH = CF ₂ , CH ₂ CF = CF ₂ , CH ₂ CH = CHCF ₃ , CH ₂
CH = CBrMe, CH ₂ CH = CClMe, CH ₂ CH = CCF ₃ Me, CF ₂ CF = CF ₂ , CH
₂ C CI, CH ₂ CH ₂ C CI, CH ₂ C CCF ₃ , CH ₂ CH ₂ C CCF ₃ , CH
₂ CN, CH ₂ CH ₂ CN, CHMeCN, CH ₂ CHMeCN, CH ₂ CMe ₂ CN, CH ₂ CH =
CHCN, CH ₂ CH (CN) CH = CH ₂ , CH ₂ C (CN) = CH ₂ , CH ₂ C (CN) = CHM
e, CH ₂ CH (CN) C CH, CH ₂ CH (CN) C CMe, CH (CN) C CH, C
H ₂ NO ₂ , CH ₂ CH ₂ NO ₂ , CHMeNO ₂ , CH ₂ CHMeNO ₂ , CH ₂ CMe ₂ NO ₂ ,
CH ₂ CH = CHNO ₂ , CH ₂ CH (NO ₂ ) CH = CH ₂ , CH ₂ C (NO ₂ ) = CH ₂ , CH ₂ C
(NO ₂ ) = CHMe, CH ₂ CH (NO ₂ ) C CH, CH ₂ CH (NO ₂ ) C CMe, CH
(NO ₂ ) C CH,

CH_TwoCO_TwoMe, CH_TwoCO_TwoEt, CH_TwoCO_TwoPr-n, CH_TwoCO_Two
Pr-iso, CH_TwoCO_TwoBu-n, CHMeCO_TwoMe, CHMeCO_TwoEt, CH_TwoCH_TwoCO
_TwoMe, CH_TwoCH_TwoCO_TwoEt, CH_TwoCHMeCO_TwoMe, CH_TwoCH_TwoCH_TwoCO_TwoMe, CH
_TwoCH = CHCO_TwoMe, CH_TwoCH = CHCO_TwoEt, CH_TwoCH = CHCO_TwoPr-n, CH_TwoCH
= CMeCO_TwoMe, CH_TwoCMe = CHCO_TwoMe, CHMeCH = CHCO_TwoMe, CHMeCH =
CHCO_TwoEt, CH_TwoCH_TwoCH = CHCO_TwoMe, CH_TwoCH = CHCH_TwoCO_TwoMe, CH_TwoCC
CO_TwoMe, CH_TwoC CCO_TwoEt, CH_TwoC CCO_TwoPr-n, CH_TwoCH_TwoC CCO_Two
Me, CH_TwoCHMeC CCO_TwoMe, CH_TwoCMe_TwoC CCO_TwoMe, CH_TwoC CCH_Two
CO_TwoMe, CH_TwoCOMe, CH_TwoCOEt, CH_TwoCOPr-n, CH_TwoCH _TwoCOMe, CH
_TwoCH_TwoCOEt, CH_TwoCHMeCOMe, CH_TwoCMe_TwoCOMe, CH_TwoCOCF_Three, CH_TwoC
OCCl_Three, CH_TwoCH_TwoCOCF_Three, CH_TwoCOCH_TwoCF_Three, CH_TwoCOCH_TwoCHF_Two, CH_Two
COCH_TwoCHCl_Two, CH_TwoCOCH_TwoF, CH_TwoCOCH_TwoCl, CH_TwoCOCH_TwoBr, CH_TwoC
OCH = CH_Two, CH_TwoCOCH = CHMe, CH_TwoCOCH_TwoCH = CH_Two, CH_TwoCH_TwoCOCH =
CH_Two, CH_TwoCH_TwoCOCH = CHMe, CH_TwoCOC CH, CH_TwoCOC CMe, CH_Two
COCH_TwoC CH, CH_TwoCH_TwoCOC CH, CH_TwoCH_TwoCOC CMe,

PhCH_Two, 2-Cl-PhCH_Two, 3-Cl-PhCH_Two, 4-Cl-Ph
CH_Two, 2,4-Cl_Two-PhCH_Two, 3,5-Cl_Two-PhCH_Two, 2,6-Cl_Two-PhCH_Two,
2,3-Cl_Two-PhCH_Two, 2,5-Cl_Two-PhCH_Two, 2-F-PhCH_Two, 3-F-PhC
H_Two, 4-F-PhCH_Two, 2-F-4-Cl-PhCH_Two, 2-Br-PhCH_Two, 3-Br-Ph
CH_Two, 4-Br-PhCH_Two, 2-Me-PhCH_Two, 3-Me-PhCH_Two, 4-Me-PhCH
_Two, 2,4-Me_Two-PhCH_Two, 3,5-Me_Two-PhCH_Two, 2,6-Me_Two-PhCH_Two, 2,
3-Me_Two-PhCH_Two, 2,5-Me_Two-PhCH_Two, 2-MeO-PhCH_Two, 3-MeO-PhC
H_Two, 4-MeO-PhCH_Two, 2-CF_Three-PhCH_Two, 3-CF_Three-PhCH_Two, 4-CF_Three-P
hCH_Two, 2,4,6-Cl_Three-PhCH_Two, 2,3,5-Cl_Three-PhCH_Two, 2,3,4-Cl_Three-
PhCH_Two, 2-NO_Two-PhCH_Two, 3-NO_Two-PhCH_Two, 4-NO_Two-PhCH_Two, 2-CN
-PhCH_Two, 3-CN-PhCH_Two, 4-CN-PhCH_Two, PhCH_TwoCH_Two, 2-Cl-PhC
H_TwoCH_Two, 3-Cl-PhCH_TwoCH_Two, 4-Cl-PhCH_TwoCH_Two, 2,4-Cl_Two-PhCH_Two
CH_Two, 3,5-Cl_Two-PhCH_TwoCH_Two, 2,6-Cl_Two-PhCH_TwoCH_Two, 2,3-Cl_Two-P
hCH_TwoCH_Two, 2,5-Cl_Two-PhCH_TwoCH_Two, 2-F-PhCH_TwoCH_Two, 3-F-PhCH_Two
CH_Two, 4-F-PhCH_TwoCH_Two, 2-F-4-Cl-PhCH_TwoCH_Two, 2-Br-PhCH_TwoCH
_Two, 3-Br-PhCH_TwoCH_Two, 4-Br-PhCH_TwoCH_Two, 2-Me-PhCH_TwoCH_Two, 3-
Me-PhCH_TwoCH_Two, 4-Me-PhCH_TwoCH_Two, 2,4-Me_Two-PhCH_TwoCH_Two, 3,5-
Me_Two-PhCH_TwoCH_Two, 2,6-Me_Two-PhCH_TwoCH_Two, 2,3-Me_Two-PhCH_TwoCH_Two,
2,5-Me_Two-PhCH_TwoCH_Two, 2-MeO-PhCH_TwoCH_Two, 3-MeO-PhCH_TwoCH_Two,Four
-MeO-PhCH_TwoCH_Two, 2-CF_Three-PhCH_TwoCH_Two, 3-CF_Three-PhCH_TwoCH_Two, 4-C
F_Three-PhCH_TwoCH_Two, 2,4,6-Cl _Three-PhCH_TwoCH_Two, 2,3,5-Cl_Three-PhCH_TwoCH
_Two, 2,3,4-Cl_Three-PhCH_TwoCH_Two, 2-NO_Two-PhCH_TwoCH_Two, 3-NO _Two-PhCH_Two
CH_Two, 4-NO_Two-PhCH_TwoCH_Two, 2-CN-PhCH_TwoCH_Two, 3-CN-PhCH_TwoCH_Two,
 4-CN-PhCH_TwoCH_Two,

PhCHMe, 2-Cl-PhCHMe, 3-Cl-PhCHMe, 4-Cl
-PhCHMe, 2,4-Cl_Two-PhCHMe, 3,5-Cl_Two-PhCHMe, 2,6-Cl_Two-P
hCHMe, 2,3-Cl_Two-PhCHMe, 2,5-Cl_Two-PhCHMe, 2-F-PhCHMe,
 3-F-PhCHMe, 4-F-PhCHMe, 2-F-4-Cl-PhCHMe, 2-Br-PhC
HMe, 3-Br-PhCHMe, 4-Br-PhCHMe, 2-Me-PhCHMe, 3-Me-P
hCHMe, 4-Me-PhCHMe, PhCHMeCH_Two, 2-Cl-PhCHMeCH_Two, 3-C
l-PhCHMeCH_Two, 4-Cl-PhCHMeCH_Two, 2,4-Cl_Two-PhCHMeCH_Two, 3,
5-Cl_Two-PhCHMeCH_Two, 2,6-Cl_Two-PhCHMeCH_Two, 2,3-Cl_Two-PhCHMe
CH_Two, 2,5-Cl_Two-PhCHMeCH_Two, 2-F-PhCHMeCH_Two, 3-F-PhCHMeC
H_Two, 4-F-PhCHMeCH_Two, 2-F-4-Cl-PhCHMeCH_Two, 2-Br-PhCHMe
CH_Two, 3-Br-PhCHMeCH_Two, 4-Br-PhCHMeCH_Two, 2-Me-PhCHMeCH
_Two, 3-Me-PhCHMeCH_Two, 4-Me-PhCHMeCH_Two, PhCH_TwoCHMe, 2-Cl
-PhCH_TwoCHMe, 3-Cl-PhCH_TwoCHMe, 4-Cl-PhCH_TwoCHMe, 2,4-Cl
_Two-PhCH_TwoCHMe, 3,5-Cl_Two-PhCH_TwoCHMe, 2,6-Cl_Two-PhCH_TwoCHMe,
 2,3-Cl_Two-PhCH_TwoCHMe, 2,5-Cl_Two-PhCH _TwoCHMe, 2-F-PhCH_TwoCH
Me, 3-F-PhCH_TwoCHMe, 4-F-PhCH_TwoCHMe, 2-F-4-Cl-PhCH_TwoCH
Me, 2-Br-PhCH_TwoCHMe, 3-Br-PhCH_TwoCHMe, 4-Br-PhCH_TwoCHMe,
 2-Me-PhCH_TwoCHMe, 3-Me-PhCH_TwoCHMe, 4-Me-PhCH_TwoCHMe, P
hCMe_Two, PhCHMeCHMe, PhCH_TwoCH_TwoCH_Two, PhCH_TwoCH_TwoCH_TwoCH_Two, PhC
H_TwoCH_TwoCH_TwoCH_TwoCH_Two, PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoCH_Two, PhCHEt, PhCH
Pr-n, PhCHPr-iso, Ph_TwoCH,

CO ₂ Me, CO ₂ Et, CO ₂ Pr-n, CO ₂ Pr-iso, CO ₂ B
un, CO ₂ Bu-iso, CO ₂ Bu-sec, CO ₂ Bu-tert, CO ₂ Pen-n, C
O ₂ CH ₂ Ph, PhOCO, 2-Cl-PhOCO, 3-Cl-PhOCO, 4-Cl-PhOC
O, 2,4-Cl ₂ -PhOCO, 3,5-Cl ₂ -PhOCO, 2,6-Cl ₂ -PhOCO, 2,
3-Cl ₂ -PhOCO, 2,5-Cl ₂ -PhOCO, 2-F-PhOCO, 3-F-PhOCO,
4-F-PhOCO, 2-F-4-Cl-PhOCO, 2-Br-PhOCO, 3-Br-PhOCO,
4-Br-PhOCO, 2-Me-PhOCO, 3-Me-PhOCO, 4-Me-PhOCO, 2,
4-Me ₂ -PhOCO, 3,5-Me ₂ -PhOCO, 2,6-Me ₂ -PhOCO, 2,3-Me ₂
-PhOCO, 2,5-Me ₂ -PhOCO, 2-MeO-PhOCO, 3-MeO-PhOCO, 4
-MeO-PhOCO, 2-CF ₃ -PhOCO, 3-CF ₃ -PhOCO, 4-CF ₃ -PhOCO,
2,4,6-Cl ₃ -PhOCO, 2,3,5-Cl ₃ -PhOCO, 2,3,4-Cl ₃ -PhOC
O, 2-NO ₂ -PhOCO, 3-NO ₂ -PhOCO, 4-NO ₂ -PhOCO, 2-CN-PhO
CO, 3-CN-PhOCO, 4-CN-PhOCO,

MeCO, EtCO, (Pr-n) CO, (Pr-iso) CO, (Bu-
n) CO, (Bu-iso) CO, (Bu-sec) CO, (Bu-tert) CO, (Pen-n)
CO, (Hex-n) CO, (Hep-n) CO, (Pr-cyc) CO, (Bu-cyc) CO,
(Pen-cyc) CO, (Hex-cyc) CO, COCH_TwoPr-cyc, COCH_TwoBu-cy
c, COCH_TwoPen-cyc, COCH_TwoHex-cyc, COCH_TwoCH_TwoPr-cyc, COC
H_TwoCH = CH_Two, COCH_TwoCH = CHMe, COCH_TwoCH = CHEt, COCH_TwoCMe = C
H_Two, COCH_TwoCH_TwoCH = CH_Two, COCH_TwoCH_TwoCH = CHMe, COCH_TwoCH = CMe_Two,
COCHMeCH = CH_Two, COCH_TwoCMe = CHMe, COCHMeCH = CHMe, COCH_TwoC
Me = CHEt, COCH_TwoCH_TwoCH = CMe_Two, COCH_TwoCMe = CMe_Two, COCH_TwoC C
H, COCH_TwoC CMe, COCH_TwoC CEt, COCH_TwoCH_TwoC CH, COCH_TwoC
H_TwoC CMe, COCHMeCCH, COCHMeC CMe, PhCO, 2-Cl-PhC
O, 3-Cl-PhCO, 4-Cl-PhCO, 2,4-Cl_Two-PhCO, 3,5-Cl_Two-PhC
O, 2,6-Cl_Two-PhCO, 2,3-Cl_Two-PhCO, 2,5-Cl_Two-PhCO, 2-F-P
hCO, 3-F-PhCO, 4-F-PhCO, 2-F-4-Cl-PhCO, 2-Br-PhCO,
 3-Br-PhCO, 4-Br-PhCO, 2-Me-PhCO, 3-Me-PhCO, 4-Me-
PhCO, 2,4-Me_Two-PhCO, 3,5-Me_Two-PhCO, 2,6-Me_Two-PhCO, 2,
3-Me _Two-PhCO, 2,5-Me_Two-PhCO, 2-MeO-PhCO, 3-MeO-PhCO,
4-MeO-PhCO, 2-CF_Three-PhCO, 3-CF_Three-PhCO, 4-CF_Three-PhCO, 2,
4,6-Cl_Three-PhCO, 2,3,5-Cl_Three-PhCO, 2,3,4-Cl_Three-PhCO, 2-NO
_Two-PhCO, 3-NO_Two-PhCO, 4-NO_Two-PhCO, 2-CN-PhCO, 3-CN-Ph
CO, 4-CN-PhCO,

OMe, OEt, OPr-n, OPr-iso, OBu-n, OBu-i
so, OBu-sec, OBu-tert, OPen-n, Et_TwoCHO, OHex-n, OHe
p-n, OOct-n, Me (Pr-n) CHO, Me (Bu-n) CHO, Et (Pr-n) CH
O, Et (Bu-n) CHO, (Pr-n)_TwoCHO, Me (Pen-n) CHO, Et (Pen-
n) CHO, (Pr-n) (Bu-n) CHO, Me_TwoCHCH_TwoCH_TwoO, OPr-cyc, OBu
-cyc, OPen-cyc, OHex-cyc, OCH_TwoPr-cyc, OCH_TwoBu-cyc,
OCH_TwoPen-cyc, OCH_TwoHex-cyc, OCH_TwoCH_TwoPr-cyc, OCH_TwoCH = CH
_Two, OCH_TwoCH = CHMe, OCH_TwoCH = CHEt, OCH_TwoCMe = CH_Two, OCH_TwoCH_TwoC
H = CH_Two, OCH_TwoCH_TwoCH = CHMe, OCH_TwoCH = CMe_Two, OCHMeCH = CH _Two, O
CH_TwoCMe = CHMe, OCHMeCH = CHMe, OCH_TwoCMe = CHEt, OCH_TwoCH_TwoCH
= CMe_Two, OCH_TwoCMe = CMe _Two, OCH_TwoC CH, OCH_TwoC CMe, OCH_TwoC
 CEt, OCH_TwoCH_TwoC CH, OCH_TwoCH_TwoC CMe, OCHMeC CH, OC
HMeC CMe, OCH_TwoOMe, OCH_TwoOEt, OCH_TwoOPr-n, OCH_TwoOPr-is
o, OCH_TwoOBu-n, OCH_TwoOBu-iso, OCH_TwoOBu-sec, OCH_TwoOBu-ter
t, OCH_TwoCH_TwoOMe, OCH_TwoCH_TwoOEt, OCH_TwoCH_TwoOPr-n, OCH_TwoCH_TwoCH
_TwoOMe, OCH_TwoCH_TwoCH_TwoOEt, OCH_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoO, 2-Cl-PhCH_TwoO, 3-Cl-PhCH_TwoO, 4-Cl
-PhCH_TwoO, 2,4-Cl_Two-PhCH_TwoO, 3,5-Cl_Two-PhCH_TwoO, 2,6-Cl_Two-P
hCH_TwoO, 2,3-Cl_Two-PhCH_TwoO, 2,5-Cl_Two-PhCH_TwoO, 2-F-PhCH_TwoO,
 3-F-PhCH_TwoO, 4-F-PhCH_TwoO, 2-F-4-Cl-PhCH_TwoO, 2-Br-PhC
H_TwoO, 3-Br-PhCH_TwoO, 4-Br-PhCH_TwoO, 2-Me-PhCH_TwoO, 3-Me-P
hCH_TwoO, 4-Me-PhCH_TwoO, 2,4-Me_Two-PhCH_TwoO, 3,5-Me_Two-PhCH
_TwoO, 2,6-Me_Two-PhCH_TwoO, 2,3-Me_Two-PhCH_TwoO, 2,5-Me_Two-PhCH
_TwoO, 2-MeO-PhCH_TwoO, 3-MeO-PhCH_TwoO, 4-MeO-PhCH_TwoO, 2-CF
_Three-PhCH_TwoO, 3-CF_Three-PhCH_TwoO, 4-CF_Three-PhCH_TwoO, 2,4,6-Cl_Three-Ph
CH_TwoO, 2,3,5-Cl_Three-PhCH_TwoO, 2,3,4-Cl_Three-PhCH_TwoO, 2-NO_Two-Ph
CH_TwoO, 3-NO_Two-PhCH_TwoO, 4-NO_Two-PhCH_TwoO, 2-CN-PhCH_TwoO, 3-CN
-PhCH_TwoO, 4-CN-PhCH_TwoO, PhCH_TwoCH_TwoO, 2-Cl-PhCH_TwoCH_TwoO, 3
-Cl-PhCH_TwoCH_TwoO, 4-Cl-PhCH_TwoCH_TwoO, 2,4-Cl_Two-PhCH_TwoCH_TwoO,
3,5-Cl_Two-PhCH_TwoCH_TwoO, 2,6-Cl_Two-PhCH_TwoCH_TwoO, 2,3-Cl_Two-PhCH
_TwoCH_TwoO, 2,5-Cl_Two-PhCH_TwoCH_TwoO, 2-F-PhCH_TwoCH_TwoO, 3-F-PhCH_Two
CH_TwoO, 4-F-PhCH_TwoCH_TwoO, 2-F-4-Cl-PhCH_TwoCH_TwoO, 2-Br-PhCH
_TwoCH_TwoO, 3-Br-PhCH_TwoCH_TwoO, 4-Br-PhCH_TwoCH_TwoO, 2-Me-PhCH_TwoCH
_TwoO, 3-Me-PhCH_TwoCH_TwoO, 4-Me-PhCH_TwoCH_TwoO, 2,4-Me_Two-PhCH_TwoC
H_TwoO, 3,5-Me_Two-PhCH_TwoCH_TwoO, 2,6-Me_Two-PhCH_TwoCH_TwoO, 2,3-Me_Two
-PhCH_TwoCH_TwoO, 2,5-Me_Two-PhCH_TwoCH_TwoO, 2-MeO-PhCH_TwoCH_TwoO, 3-
MeO-PhCH_TwoCH_TwoO, 4-MeO-PhCH_TwoCH_TwoO, 2-CF_Three-PhCH_TwoCH_TwoO, 3
-CF_Three-PhCH_TwoCH_TwoO, 4-CF_Three-PhCH_TwoCH_TwoO, 2,4,6-Cl_Three-PhCH_TwoCH
_TwoO, 2,3,5-Cl_Three-PhCH_TwoCH_TwoO, 2,3,4-Cl_Three-PhCH_TwoCH_TwoO, 2-NO
_Two-PhCH_TwoCH_TwoO, 3-NO_Two-PhCH_TwoCH_TwoO, 4-NO_Two-PhCH_TwoCH_TwoO, 2-C
N-PhCH_TwoCH_TwoO, 3-CN-PhCH_TwoCH_TwoO, 4-CN-PhCH _TwoCH_TwoO,

PhCH (Me) O, 2-Cl-PhCH (Me) O, 3-Cl-PhCH (M
e) O, 4-Cl- PhCH (Me) O, 2,4-Cl 2 -PhCH (Me) O, 3,5-Cl 2 -Ph
CH (Me) O, 2,6-Cl ₂ -PhCH (Me) O, 2,3-Cl ₂ -PhCH (Me) O, 2,5
-Cl ₂ -PhCH (Me) O, 2-F-PhCH (Me) O, 3-F-PhCH (Me) O, 4-F-
PhCH (Me) O, 2-F-4-Cl-PhCH (Me) O, 2-Br-PhCH (Me) O, 3-B
r-PhCH (Me) O, 4-Br-PhCH (Me) O, 2-Me-PhCH (Me) O, 3-Me-
PhCH (Me) O, 4-Me-PhCH (Me) O, PhCHMeCH ₂ O, 2-Cl-PhCHMe
CH ₂ O, 3-Cl-PhCHMeCH ₂ O, 4-Cl-PhCHMeCH ₂ O, 2,4-Cl ₂ -PhC
HMeCH ₂ O, 3,5-Cl ₂ -PhCHMeCH ₂ O, 2,6-Cl ₂ -PhCHMeCH ₂ O,
2,3-Cl ₂ -PhCHMeCH ₂ O, 2,5-Cl ₂ -PhCHMeCH ₂ O, 2-F-PhCHMe
CH ₂ O, 3-F-PhCHMeCH ₂ O, 4-F-PhCHMeCH ₂ O, 2-F-4-Cl-PhC
HMeCH ₂ O, 2-Br-PhCHMeCH ₂ O, 3-Br-PhCHMeMe ₂ O, 4-Br-Ph
CHMeCH ₂ O, 2-Me-PhCHMeCH ₂ O, 3-Me-PhCHMeCH ₂ O, 4-Me-P
hCHMeCH ₂ O, PhCH ₂ CH, 2-Cl-PhCH ₂ CH (Me) O, 3-Cl-PhCH ₂ CH
(Me) O, 4-Cl-PhCH ₂ CH (Me) O, 2,4-Cl ₂ -PhCH ₂ CH (Me) O, 3,
5-Cl ₂ -PhCH ₂ CH (Me) O, 2,6-Cl ₂ -PhCH ₂ CH (Me) O, 2,3-Cl _2-
PhCH ₂ CH (Me) O, 2,5-Cl ₂ -PhCH ₂ CH (Me) O, 2-F-PhCH ₂ CH (M
e) O, 3-F-PhCH ₂ CH (Me) O, 4-F-PhCH ₂ CH (Me) O, 2-F-4-Cl-
PhCH ₂ CH (Me) O, 2-Br-PhCH ₂ CH (Me) O, 3-Br-PhCH ₂ CH (Me)
O, 4-Br-PhCH ₂ CH (Me) O, 2-Me-PhCH ₂ CH (Me) O, 3-Me-PhCH
₂ CH (Me) O, 4-Me-PhCH ₂ CH (Me) O, PhCMe ₂ O, PhCHMeCH (Me)
O, PhCH ₂ CH ₂ CH ₂ O, PhCH ₂ CH ₂ CH ₂ CH ₂ O, PhCH ₂ CH ₂ CH ₂ CH ₂ CH
₂ O, PhCH ₂ CH ₂ CH ₂ CH ₂ CH ₂ CH ₂ O,

PhO, 2-Cl-PhO, 3-Cl-PhO, 4-Cl-PhO, 2,4
-Cl ₂ -PhO, 3,5-Cl ₂ -PhO, 2,6-Cl ₂ -PhO, 2,3-Cl ₂ -PhO,
2,5-Cl ₂ -PhO, 2-F-PhO, 3-F-PhO, 4-F-PhO, 2-F-4-Cl-P
hO, 2-Br-PhO, 3-Br-PhO, 4-Br-PhO, 2-Me-PhO, 3-Me-P
hO, 4-Me-PhO, 2,4-Me ₂ -PhO, 3,5-Me ₂ -PhO, 2,6-Me ₂ -Ph
O, 2,3-Me ₂ -PhO, 2,5-Me ₂ -PhO, 2-MeO-PhO, 3-MeO-PhO,
4-MeO-PhO, 2-CF ₃ -PhO, 3-CF ₃ -PhO, 4-CF ₃ -PhO, 2,4,6-
Cl ₃ -PhO, 2,3,5-Cl ₃ -PhO, 2,3,4-Cl ₃ -PhO, 2-NO ₂ -PhO, 3
-NO ₂ -PhO, 4-NO ₂ -PhO, 2,4- (NO ₂ ) ₂ -PhO, 2-CN-PhO, 3-C
N-PhO, 4-CN-PhO,

SMe, SEt, SPr-n, SPr-iso, SBu-n, SBu-i
so, SBu-sec, SBu-tert, SPen-n, Et_TwoCHS, SHex-n, SHe
p-n, SOct-n, Me (Pr-n) CHS, Me (Bu-n) CHS, Et (Pr-n) CH
S, Et (Bu-n) CHS, (Pr-n)_TwoCHS, Me (Pen-n) CHS, Et (Pen-
n) CHS, (Pr-n) (Bu-n) CHS, Me_TwoCHCH_TwoCH_TwoS, SPr-cyc, SBu
-cyc, SPen-cyc, SHex-cyc, SCH_TwoPr-cyc, SCH_TwoBu-cyc,
SCH_TwoPen-cyc, SCH_TwoHex-cyc, SCH_TwoCH_TwoPr-cyc, SCH_TwoCH = CH
_Two, SCH_TwoCH = CHMe, SCH_TwoCH = CHEt, SCH_TwoCMe = CH_Two, SCH_TwoCH_TwoC
H = CH_Two, SCH_TwoCH_TwoCH = CHMe, SCH_TwoCH = CMe_Two, SCHMeCH = CH _Two, S
CH_TwoCMe = CHMe, SCHMeCH = CHMe, SCH_TwoCMe = CHEt, SCH_TwoCH_TwoCH
= CMe_Two, SCH_TwoCMe = CMe _Two, SCH_TwoC CH, SCH_TwoC CMe, SCH_TwoC
 CEt, SCH_TwoCH_TwoC CH, SCH_TwoCH_TwoC CMe, SCHMeC CH, SC
HMeC CMe, SCH_TwoOMe, SCH_TwoOEt, SCH_TwoOPr-n, SCH_TwoOPr-is
o, SCH_TwoOBu-n, SCH_TwoOBu-iso, SCH_TwoOBu-sec, SCH_TwoOBu-ter
t, SCH_TwoCH_TwoOMe, SCH_TwoCH_TwoOEt, SCH_TwoCH_TwoOPr-n, SCH_TwoCH_TwoCH
_TwoOMe, SCH_TwoCH_TwoCH_TwoOEt, SCH_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoS, 2-Cl-PhCH_TwoS, 3-Cl-PhCH_TwoS, 4-Cl
-PhCH_TwoS, 2,4-Cl_Two-PhCH_TwoS, 3,5-Cl_Two-PhCH_TwoS, 2,6-Cl_Two-P
hCH_TwoS, 2,3-Cl_Two-PhCH_TwoS, 2,5-Cl_Two-PhCH_TwoS, 2-F-PhCH_TwoS,
 3-F-PhCH_TwoS, 4-F-PhCH_TwoS, 2-F-4-Cl-PhCH_TwoS, 2-Br-PhC
H_TwoS, 3-Br-PhCH_TwoS, 4-Br-PhCH_TwoS, 2-Me-PhCH_TwoS, 3-Me-P
hCH_TwoS, 4-Me-PhCH_TwoS, 2,4-Me_Two-PhCH_TwoS, 3,5-Me_Two-PhCH
_TwoS, 2,6-Me_Two-PhCH_TwoS, 2,3-Me_Two-PhCH_TwoS, 2,5-Me_Two-PhCH
_TwoS, 2-MeO-PhCH_TwoS, 3-MeO-PhCH_TwoS, 4-MeO-PhCH_TwoS, 2-CF
_Three-PhCH_TwoS, 3-CF_Three-PhCH_TwoS, 4-CF_Three-PhCH_TwoS, 2,4,6-Cl_Three-Ph
CH_TwoS, 2,3,5-Cl_Three-PhCH_TwoS, 2,3,4-Cl_Three-PhCH_TwoS, 2-NO_Two-Ph
CH_TwoS, 3-NO_Two-PhCH_TwoS, 4-NO_Two-PhCH_TwoS, 2-CN-PhCH_TwoS, 3-CN
-PhCH_TwoS, 4-CN-PhCH_TwoS, PhCH_TwoCH_TwoS, 2-Cl-PhCH_TwoCH_TwoS, 3
-Cl-PhCH_TwoCH_TwoS, 4-Cl-PhCH_TwoCH_TwoS, 2,4-Cl_Two-PhCH_TwoCH_TwoS,
3,5-Cl_Two-PhCH_TwoCH_TwoS, 2,6-Cl_Two-PhCH_TwoCH_TwoS, 2,3-Cl_Two-PhCH
_TwoCH_TwoS, 2,5-Cl_Two-PhCH_TwoCH_TwoS, 2-F-PhCH_TwoCH_TwoS, 3-F-PhCH_Two
CH_TwoS, 4-F-PhCH_TwoCH_TwoS, 2-F-4-Cl-PhCH_TwoCH_TwoS, 2-Br-PhCH
_TwoCH_TwoS, 3-Br-PhCH_TwoCH_TwoS, 4-Br-PhCH_TwoCH_TwoS, 2-Me-PhCH_TwoCH
_TwoS, 3-Me-PhCH_TwoCH_TwoS, 4-Me-PhCH_TwoCH_TwoS, 2,4-Me_Two-PhCH_TwoC
H_TwoS, 3,5-Me_Two-PhCH_TwoCH_TwoS, 2,6-Me_Two-PhCH_TwoCH_TwoS, 2,3-Me_Two
-PhCH_TwoCH_TwoS, 2,5-Me_Two-PhCH_TwoCH_TwoS, 2-MeO-PhCH_TwoCH_TwoS, 3-
MeO-PhCH_TwoCH_TwoS, 4-MeO-PhCH_TwoCH_TwoS, 2-CF_Three-PhCH_TwoCH_TwoS, 3
-CF_Three-PhCH_TwoCH_TwoS, 4-CF_Three-PhCH_TwoCH_TwoS, 2,4,6-Cl_Three-PhCH_TwoCH
_TwoS, 2,3,5-Cl_Three-PhCH_TwoCH_TwoS, 2,3,4-Cl_Three-PhCH_TwoCH_TwoS, 2-NO
_Two-PhCH_TwoCH_TwoS, 3-NO_Two-PhCH_TwoCH_TwoS, 4-NO_Two-PhCH_TwoCH_TwoS, 2-C
N-PhCH_TwoCH_TwoS, 3-CN-PhCH_TwoCH_TwoS, 4-CN-PhCH _TwoCH_TwoS, PhCH
(Me) S, 2-Cl-PhCH (Me) S, 3-Cl-PhCH (Me) S, 4-Cl-PhCH (M
e) S, 2,4-Cl _Two-PhCH (Me) S, 3,5-Cl_Two-PhCH (Me) S, 2,6-Cl_Two
-PhCH (Me) S, 2,3-Cl_Two-PhCH (Me) S, 2,5-Cl_Two-PhCH (Me) S,
2-F-PhCH (Me) S, 3-F-PhCH (Me) S, 4-F-PhCH (Me) S, 2-F-4
-Cl-PhCH (Me) S, 2-Br-PhCH (Me) S, 3-Br-PhCH (Me) S, 4-B
r-PhCH (Me) S, 2-Me-PhCH (Me) S, 3-Me-PhCH (Me) S, 4-Me-
PhCH (Me) S, PhCHMeCH_TwoS, 2-Cl-PhCHMeCH_TwoS, 3-Cl-PhCHM
eCH_TwoS, 4-Cl-PhCHMeCH_TwoS, 2,4-Cl_Two-PhCHMeCH_TwoS, 3,5-Cl
_Two-PhCHMeCH_TwoS, 2,6-Cl_Two-PhCHMeCH_TwoS, 2,3-Cl_Two-PhCHMeCH
_TwoS, 2,5-Cl_Two-PhCHMeCH_TwoS, 2-F-PhCHMeCH_TwoS, 3-F-PhCHMe
CH_TwoS, 4-F-PhCHMeCH_TwoS, 2-F-4-Cl-PhCHMeCH_TwoS, 2-Br-Ph
CHMeCH_TwoS, 3-Br-PhCHMeCH_TwoS, 4-Br-PhCHMeCH_TwoS, 2-Me-P
hCHMeCH_TwoS, 3-Me-PhCHMeCH_TwoS, 4-Me-PhCHMeCH_TwoS, PhCH_Two
CH, 2-Cl-PhCH_TwoCH (Me) S, 3-Cl-PhCH_TwoCH (Me) S, 4-Cl-PhC
H_TwoCH (Me) S, 2,4-Cl_Two-PhCH_TwoCH (Me) S, 3,5-Cl_Two-PhCH_TwoCH (M
e) S, 2,6-Cl_Two-PhCH_TwoCH (Me) S, 2,3-Cl_Two-PhCH_TwoCH (Me) S,
2,5-Cl_Two-PhCH_TwoCH (Me) S, 2-F-PhCH_TwoCH (Me) S, 3-F-PhCH_TwoC
H (Me) S, 4-F-PhCH_TwoCH (Me) S, 2-F-4-Cl-PhCH_TwoCH (Me) S, 2
-Br-PhCH_TwoCH (Me) S, 3-Br-PhCH_TwoCH (Me) S, 4-Br-PhCH_TwoCH
(Me) S, 2-Me-PhCH_TwoCH (Me) S, 3-Me-PhCH_TwoCH (Me) S, 4-Me-
PhCH_TwoCH (Me) S, PhCMe_TwoS, PhCHMeCH (Me) S, PhCH_TwoCH_TwoCH
_TwoS, PhCH_TwoCH_TwoCH_TwoCH_TwoS, PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoS, PhCH_TwoCH_TwoC
H_TwoCH_TwoCH_TwoCH_TwoS,

PhS, 2-Cl-PhS, 3-Cl-PhS, 4-Cl-PhS, 2,4
-Cl ₂ -PhS, 3,5-Cl ₂ -PhS, 2,6-Cl ₂ -PhS, 2,3-Cl ₂ -PhS,
2,5-Cl ₂ -PhS, 2-F-PhS, 3-F-PhS, 4-F-PhS, 2-F-4-Cl-P
hS, 2-Br-PhS, 3-Br-PhS, 4-Br-PhS, 2-Me-PhS, 3-Me-P
hS, 4-Me-PhS, 2,4-Me ₂ -PhS, 3,5-Me ₂ -PhS, 2,6-Me ₂ -Ph
S, 2,3-Me ₂ -PhS, 2,5-Me ₂ -PhS, 2-MeO-PhS, 3-MeO-PhS,
4-MeO-PhS, 2-CF ₃ -PhS, 3-CF ₃ -PhS, 4-CF ₃ -PhS, 2,4,6-
Cl ₃ -PhS, 2,3,5-Cl ₃ -PhS, 2,3,4-Cl ₃ -PhS, 2-NO ₂ -PhS, 3
-NO ₂ -PhS, 4-NO ₂ -PhS, 2,4- (NO ₂ ) ₂ -PhS, 2-CN-PhS, 3-C
N-PhS, 4-CN-PhS,

S (O) Me, S (O) Et, S (O) Pr-n, S (O) Pr-iso,
S (O) Bu-n, S (O) Bu-iso, S (O) Bu-sec, S (O) Bu-tert, S (O)
Pen-n, Et_TwoCHS (O), S (O) Hex-n, S (O) Hep-n, S (O) Oct-n,
 Me (Pr-n) CHS (O), Me (Bu-n) CHS (O), Et (Pr-n) CHS (O), E
t (Bu-n) CHS (O), (Pr-n)_TwoCHS (O), Me (Pen-n) CHS (O), Et
(Pen-n) CHS (O), (Pr-n) (Bu-n) CHS (O), Me_TwoCHCH_TwoCH_TwoS
(O), S (O) Pr-cyc, S (O) Bu-cyc, S (O) Pen-cyc, S (O) Hex-
cyc, S (O) CH_TwoPr-cyc, S (O) CH_TwoBu-cyc, S (O) CH_TwoPen-cyc,
 S (O) CH_TwoHex-cyc, S (O) CH_TwoCH_TwoPr-cyc, S (O) CH_TwoCH = CH _Two,
S (O) CH_TwoCH = CHMe, S (O) CH_TwoCH = CHEt, S (O) CH_TwoCMe = CH_Two, S
(O) CH_TwoCH_TwoCH = CH_Two, S (O) CH_TwoCH_TwoCH = CHMe, S (O) CH_TwoCH = CM
e_Two, S (O) CHMeCH = CH_Two, S (O) CH_TwoCMe = CHMe, S (O) CHMeCH = CH
Me, S (O) CH_TwoCMe = CHEt, S (O) CH_TwoCH_TwoCH = CMe_Two, S (O) CH_TwoCMe
= CMe_Two, S (O) CH_TwoCCH, S (O) CH_TwoC CMe, S (O) CH_TwoC CEt, S
(O) CH_TwoCH_TwoC CH, S (O) CH_TwoCH_TwoC CMe, S (O) CHMeC CH, S
(O) CHMeC CMe, S (O) CH_TwoOMe, S (O) CH_TwoOEt, S (O) CH_TwoOPr-
n, S (O) CH_TwoOPr-iso, S (O) CH_TwoOBu-n, S (O) CH_TwoOBu-iso, S
(O) CH_TwoOBu-sec, S (O) CH_TwoOBu-tert, S (O) CH_TwoCH_TwoOMe, S
(O) CH_TwoCH_TwoOEt, S (O) CH_TwoCH_TwoOPr-n, S (O) CH_TwoCH_TwoCH_TwoOMe, S
(O) CH_TwoCH_TwoCH_TwoOEt, S (O) CH_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoS (O), 2-Cl-PhCH_TwoS (O), 3-Cl-PhCH_TwoS
(O), 4-Cl-PhCH_TwoS (O), 2,4-Cl_Two-PhCH_TwoS (O), 3,5-Cl_Two-Ph
CH_TwoS (O), 2,6-Cl_Two-PhCH_TwoS (O), 2,3-Cl_Two-PhCH_TwoS (O), 2,5
-Cl_Two-PhCH_TwoS (O), 2-F-PhCH_TwoS (O), 3-F-PhCH_TwoS (O), 4-F-
PhCH_TwoS (O), 2-F-4-Cl-PhCH_TwoS (O), 2-Br-PhCH_TwoS (O), 3-B
r-PhCH_TwoS (O), 4-Br-PhCH_TwoS (O), 2-Me-PhCH_TwoS (O), 3-Me-
PhCH_TwoS (O), 4-Me-PhCH_TwoS (O), 2,4-Me_Two-PhCH_TwoS (O), 3,5-
Me_Two-PhCH_TwoS (O), 2,6-Me_Two-PhCH_TwoS (O), 2,3-Me_Two-PhCH_TwoS
(O), 2,5-Me_Two-PhCH_TwoS (O), 2-MeO-PhCH_TwoS (O), 3-MeO-PhC
H_TwoS (O), 4-MeO-PhCH_TwoS (O), 2-CF_Three-PhCH_TwoS (O), 3-CF_Three-Ph
CH_TwoS (O), 4-CF_Three-PhCH_TwoS (O), 2,4,6-Cl_Three-PhCH_TwoS (O), 2,
3,5-Cl_Three-PhCH_TwoS (O), 2,3,4-Cl_Three-PhCH_TwoS (O), 2-NO_Two-PhCH
_TwoS (O), 3-NO_Two-PhCH_TwoS (O), 4-NO_Two-PhCH_TwoS (O), 2-CN-PhCH
_TwoS (O), 3-CN-PhCH_TwoS (O), 4-CN-PhCH_TwoS (O), PhCH_TwoCH_TwoS
(O), 2-Cl-PhCH_TwoCH_TwoS (O), 3-Cl-PhCH_TwoCH_TwoS (O), 4-Cl-Ph
CH_TwoCH_TwoS (O), 2,4-Cl_Two-PhCH_TwoCH_TwoS (O), 3,5-Cl_Two-PhCH_TwoCH_Two
S (O), 2,6-Cl_Two-PhCH_TwoCH_TwoS (O), 2,3-Cl_Two-PhCH_TwoCH_TwoS (O),
2,5-Cl_Two-PhCH_TwoCH_TwoS (O), 2-F-PhCH_TwoCH_TwoS (O), 3-F-PhCH_TwoC
H_TwoS (O), 4-F-PhCH_TwoCH_TwoS (O), 2-F-4-Cl-PhCH_TwoCH_TwoS (O), 2
-Br-PhCH_TwoCH_TwoS (O), 3-Br-PhCH_TwoCH_TwoS (O), 4-Br-PhCH_TwoCH_Two
S (O), 2-Me-PhCH_TwoCH_TwoS (O), 3-Me-PhCH_TwoCH_TwoS (O), 4-Me-Ph
CH_TwoCH_TwoS (O), 2,4-Me_Two-PhCH_TwoCH_TwoS (O), 3,5-Me_Two-PhCH _TwoCH_Two
S (O), 2,6-Me_Two-PhCH_TwoCH_TwoS (O), 2,3-Me_Two-PhCH_TwoCH_TwoS (O),
2,5-Me_Two-PhCH_TwoCH_TwoS (O), 2-MeO-PhCH_TwoCH_TwoS (O), 3-MeO-Ph
CH_TwoCH_TwoS (O), 4-MeO-PhCH_TwoCH_TwoS (O), 2-CF_Three-PhCH_TwoCH_TwoS
(O), 3-CF_Three-PhCH_TwoCH_TwoS (O), 4-CF_Three-PhCH_TwoCH_TwoS (O), 2,4,6
-Cl_Three-PhCH_TwoCH_TwoS (O), 2,3,5-Cl_Three-PhCH_TwoCH_TwoS (O), 2,3,4-C
l_Three-PhCH_TwoCH_TwoS (O), 2-NO_Two-PhCH_TwoCH_TwoS (O), 3-NO_Two-PhCH_TwoCH_Two
S (O), 4-NO_Two-PhCH_TwoCH_TwoS (O), 2-CN-PhCH_TwoCH_TwoS (O), 3-CN-
PhCH_TwoCH_TwoS (O), 4-CN-PhCH_TwoCH_TwoS (O),

PhCH (Me) S (O), 2-Cl-PhCH (Me) S (O), 3-Cl-
PhCH (Me) S (O), 4-Cl-PhCH (Me) S (O), 2,4-Cl_Two-PhCH (Me) S
(O), 3,5-Cl_Two-PhCH (Me) S (O), 2,6-Cl_Two-PhCH (Me) S (O),
2,3-Cl_Two-PhCH (Me) S (O), 2,5-Cl_Two-PhCH (Me) S (O), 2-F-Ph
CH (Me) S (O), 3-F-PhCH (Me) S (O), 4-F-PhCH (Me) S (O), 2-F
-4-Cl-PhCH (Me) S (O), 2-Br-PhCH (Me) S (O), 3-Br-PhCH (M
e) S (O), 4-Br-PhCH (Me) S (O), 2-Me-PhCH (Me) S (O), 3-Me
-PhCH (Me) S (O), 4-Me-PhCH (Me) S (O), PhCHMeCH_TwoS (O), 2
-Cl-PhCHMeCH_TwoS (O), 3-Cl-PhCHMeCH_TwoS (O), 4-Cl-PhCHMe
CH_TwoS (O), 2,4-Cl_Two-PhCHMeCH_TwoS (O), 3,5-Cl_Two-PhCHMeCH_TwoS
(O), 2,6-Cl_Two-PhCHMeCH_TwoS (O), 2,3-Cl_Two-PhCHMeCH_TwoS (O),
 2,5-Cl_Two-PhCHMeCH_TwoS (O), 2-F-PhCHMeCH_TwoS (O), 3-F-PhC
HMeCH_TwoS (O), 4-F-PhCHMeCH_TwoS (O), 2-F-4-Cl-PhCHMeCH_TwoS
(O), 2-Br-PhCHMeCH_TwoS (O), 3-Br-PhCHMeCH_TwoS (O), 4-Br-
PhCHMeCH_TwoS (O), 2-Me-PhCHMeCH_TwoS (O), 3-Me-PhCHMeCH_TwoS
(O), 4-Me-PhCHMeCH_TwoS (O), PhCH_TwoCH, 2-Cl-PhCH_TwoCH (Me)
S (O), 3-Cl-PhCH_TwoCH (Me) S (O), 4-Cl-PhCH_TwoCH (Me) S (O),
2,4-Cl_Two-PhCH_TwoCH (Me) S (O), 3,5-Cl_Two-PhCH_TwoCH (Me) S (O),
2,6-Cl_Two-PhCH_TwoCH (Me) S (O), 2,3-Cl_Two-PhCH_TwoCH (Me) S (O),
2,5-Cl_Two-PhCH_TwoCH (Me) S (O), 2-F-PhCH_TwoCH (Me) S (O), 3-F-
PhCH_TwoCH (Me) S (O), 4-F-PhCH_TwoCH (Me) S (O), 2-F-4-Cl-PhC
H_TwoCH (Me) S (O), 2-Br-PhCH_TwoCH (Me) S (O), 3-Br-PhCH_TwoCH (M
e) S (O), 4-Br-PhCH_TwoCH (Me) S (O), 2-Me-PhCH_TwoCH (Me) S
(O), 3-Me-PhCH_TwoCH (Me) S (O), 4-Me-PhCH_TwoCH (Me) S (O), P
hCMe_TwoS (O), PhCHMeCH (Me) S (O), PhCH_TwoCH_TwoCH _TwoS (O), PhCH
_TwoCH_TwoCH_TwoCH_TwoS (O), PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoS (O), PhCH_TwoCH_TwoCH_Two
CH_TwoCH_TwoCH_TwoS (O),

PhS (O), 2-Cl-PhS (O), 3-Cl-PhS (O), 4-Cl
-PhS (O), 2,4-Cl ₂ -PhS (O), 3,5-Cl ₂ -PhS (O), 2,6-Cl ₂ -P
hS (O), 2,3-Cl ₂ -PhS (O), 2,5-Cl ₂ -PhS (O), 2-F-PhS (O),
3-F-PhS (O), 4-F-PhS (O), 2-F-4-Cl-PhS (O), 2-Br-PhS
(O), 3-Br-PhS (O), 4-Br-PhS (O), 2-Me-PhS (O), 3-Me-P
hS (O), 4-Me-PhS (O), 2,4-Me ₂ -PhS (O), 3,5-Me ₂ -PhS
(O), 2,6-Me ₂ -PhS (O), 2,3-Me ₂ -PhS (O), 2,5-Me ₂ -PhS
(O), 2-MeO-PhS (O), 3-MeO-PhS (O), 4-MeO-PhS (O), 2-C
F ₃ -PhS (O), 3-CF ₃ -PhS (O), 4-CF ₃ -PhS (O), 2,4,6-Cl ₃ -P
hS (O), 2,3,5-Cl ₃ -PhS (O), 2,3,4-Cl ₃ -PhS (O), 2-NO ₂ -P
hS (O), 3-NO ₂ -PhS (O), 4-NO ₂ -PhS (O), 2,4- (NO ₂ ) ₂ -PhS
(O), 2-CN-PhS (O), 3-CN-PhS (O), 4-CN-PhS (O),

[0119] SO_TwoMe, SO_TwoEt, SO_TwoPr-n, SO_TwoPr-iso, SO_TwoB
u-n, SO_TwoBu-iso, SO_TwoBu-sec, SO_TwoBu-tert, SO_TwoPen-n, E
t_TwoCHSO_Two, SO_TwoHex-n, SO_TwoHep-n, SO_TwoOct-n, Me (Pr-n) CHS
O_Two, Me (Bu-n) CHSO_Two, Et (Pr-n) CHSO_Two, Et (Bu-n) CHSO_Two,
(Pr-n)_TwoCHSO_Two, Me (Pen-n) CHSO_Two, Et (Pen-n) CHSO_Two, (Pr-
n) (Bu-n) CHSO_Two, Me_TwoCHCH_TwoCH_TwoSO_Two, SO_TwoPr-cyc, SO_TwoBu-cy
c, SO_TwoPen-cyc, SO_TwoHex-cyc, SO_TwoCH_TwoPr-cyc, SO_TwoCH_TwoBu-
cyc, SO_2CH_TwoPen-cyc, SO_TwoCH_TwoHex-cyc, SO_TwoCH_TwoCH_TwoPr-cy
c, SO_TwoCH_TwoCH = CH_Two, SO_TwoCH_TwoCH = CHMe, SO_TwoCH_TwoCH = CHEt, SO_TwoC
H_TwoCMe = CH_Two, SO_TwoCH_TwoCH_TwoCH = CH_Two, SO_TwoCH_TwoCH_TwoCH = CHMe, SO_TwoC
H_TwoCH = CMe_Two, SO_TwoCHMeCH = CH_Two, SO_TwoCH_TwoCMe = CHMe, SO_TwoCHMeC
H = CHMe, SO_TwoCH_TwoCMe = CHEt, SO_TwoCH_TwoCH_TwoCH = CMe _Two, SO_TwoCH_Twocm
e = CMe_Two, SO_TwoCH_TwoC CH, SO_TwoCH_TwoC CMe, SO_TwoCH_TwoC CEt, S
O_TwoCH_TwoCH_TwoCCH, SO_TwoCH_TwoCH_TwoC CMe, SO_TwoCHMeC CH, SO_TwoCHM
eC CMe, SO_TwoCH_TwoOMe, SO_TwoCH_TwoOEt, SO_TwoCH_TwoOPr-n, SO_TwoCH_TwoO
Pr-iso, SO_TwoCH_TwoOBu-n, SO_TwoCH_TwoOBu-iso, SO_TwoCH_TwoOBu-sec,
 SO_TwoCH_TwoOBu-tert, SO_TwoCH_TwoCH_TwoOMe, SO_TwoCH_TwoCH_TwoOEt, SO_TwoCH
_TwoCH_TwoOPr-n, SO_TwoCH_TwoCH_TwoCH_TwoOMe, SO_TwoCH_TwoCH_TwoCH_TwoOEt, SO_TwoCH
_TwoCH_TwoCH_TwoCH_TwoOMe,

PhCH_TwoSO_Two, 2-Cl-PhCH_TwoSO_Two, 3-Cl-PhCH_TwoS
O_Two, 4-Cl-PhCH_TwoSO_Two, 2,4-Cl_Two-PhCH_TwoSO_Two, 3,5-Cl_Two-PhCH_TwoS
O_Two, 2,6-Cl_Two-PhCH_TwoSO_Two, 2,3-Cl_Two-PhCH_TwoSO_2, 2,5-Cl_Two-Ph
CH_TwoSO_Two, 2-F-PhCH_TwoSO_Two, 3-F-PhCH_TwoSO_Two, 4-F-PhCH_TwoSO_Two, 2
-F-4-Cl-PhCH_TwoSO_Two, 2-Br-PhCH_TwoSO_Two, 3-Br-PhCH_TwoSO_Two, Four-
Br-PhCH_TwoSO2, 2-Me-PhCH_TwoSO_Two, 3-Me-PhCH_TwoSO_Two, 4-Me-Ph
CH_TwoSO_Two, 2,4-Me_Two-PhCH_TwoSO_Two, 3,5-Me_Two-PhCH_TwoSO_Two, 2,6-Me
_Two-PhCH_TwoSO_Two, 2,3-Me_Two-PhCH_TwoSO_Two, 2,5-Me_Two-PhCH_TwoSO_Two, 2-
MeO-PhCH_TwoSO_Two, 3-MeO-PhCH_TwoSO_Two, 4-MeO-PhCH_TwoSO_Two, 2-CF
_Three-PhCH_TwoSO_Two, 3-CF_Three-PhCH_TwoSO_Two, 4-CF_Three-PhCH_TwoSO_Two, 2,4,6-
Cl_Three-PhCH_TwoSO_Two, 2,3,5-Cl_Three-PhCH_TwoSO_Two, 2,3,4-Cl_Three-PhCH_TwoS
O_Two, 2-NO_Two-PhCH_TwoSO_Two, 3-NO_Two-PhCH_TwoSO_Two, 4-NO_Two-PhCH_TwoS
O_Two, 2-CN-PhCH_TwoSO_Two, 3-CN-PhCH_TwoSO_Two, 4-CN-PhCH_TwoSO_Two, P
hCH_TwoCH_TwoSO_Two, 2-Cl-PhCH_TwoCH_TwoSO_Two, 3-Cl-PhCH_TwoCH_TwoSO_Two, 4-C
l-PhCH_TwoCH_TwoSO_Two, 2,4-Cl_Two-PhCH_TwoCH_TwoSO _Two, 3,5-Cl_Two-PhCH_TwoC
H_TwoSO_Two, 2,6-Cl_Two-PhCH_TwoCH_TwoSO_Two, 2,3-Cl_Two-PhCH_TwoCH_TwoSO_Two,
2,5-Cl _Two-PhCH_TwoCH_TwoSO_Two, 2-F-PhCH_TwoCH_TwoSO_Two, 3-F-PhCH_TwoCH_Two
SO_Two, 4-F-PhCH_TwoCH_TwoSO_Two, 2-F-4-Cl-PhCH_TwoCH_TwoSO_Two, 2-Br-P
hCH_TwoCH_TwoSO_Two, 3-Br-PhCH_TwoCH_TwoSO_Two, 4-Br-PhCH_TwoCH_TwoSO_Two, 2-
Me-PhCH_TwoCH_TwoSO_Two, 3-Me-PhCH_TwoCH_TwoSO_Two, 4-Me-PhCH_TwoCH_TwoS
O_Two, 2,4-Me_Two-PhCH_TwoCH_TwoSO_Two, 3,5-Me_Two-PhCH_TwoCH_TwoSO_Two, 2,6-M
e_Two-PhCH_TwoCH_TwoSO_Two, 2,3-Me_Two-PhCH_TwoCH_TwoSO_Two, 2,5-Me_Two-PhCH_Two
CH_TwoSO_Two, 2-MeO-PhCH_TwoCH_TwoSO_Two, 3-MeO-PhCH_TwoCH_TwoSO_Two, 4-Me
O-PhCH_TwoCH_TwoSO_Two, 2-CF_Three-PhCH_TwoCH_TwoSO_Two, 3-CF_Three-PhCH_TwoCH_TwoSO
_Two, 4-CF_Three-PhCH_TwoCH_TwoSO_Two, 2,4,6-Cl_Three-PhCH_TwoCH _TwoSO_Two, 2,3,5
-Cl_Three-PhCH_TwoCH_TwoSO_Two, 2,3,4-Cl_Three-PhCH_TwoCH_TwoSO_Two, 2-NO_Two-PhC
H_TwoCH_TwoSO_Two, 3-NO_Two-PhCH_TwoCH_TwoSO_Two, 4-NO_Two-PhCH_TwoCH_TwoSO_Two, 2-
CN-PhCH_TwoCH_TwoSO_Two, 3-CN-PhCH_TwoCH_TwoSO_Two, 4-CN-PhCH_TwoCH_TwoSO_Two,

PhCH (Me) SO_Two, 2-Cl-PhCH (Me) SO_Two, 3-Cl-Ph
CH (Me) SO_Two, 4-Cl-PhCH (Me) SO_Two, 2,4-Cl_Two-PhCH (Me) SO_Two,
3,5-Cl_Two-PhCH (Me) SO_Two, 2,6-Cl_Two-PhCH (Me) SO_Two, 2,3-Cl_Two-
PhCH (Me) SO_Two, 2,5-Cl_Two-PhCH (Me) SO_Two, 2-F-PhCH (Me) SO_Two,
 3-F-PhCH (Me) SO_Two, 4-F-PhCH (Me) SO_Two, 2-F-4-Cl-PhCH (M
e) SO_Two, 2-Br-PhCH (Me) SO_Two, 3-Br-PhCH (Me) SO_Two, 4-Br-Ph
CH (Me) SO_Two, 2-Me-PhCH (Me) SO_Two, 3-Me-PhCH (Me) SO_Two, 4-M
e-PhCH (Me) SO_Two, PhCHMeCH_TwoSO_Two, 2-Cl-PhCHMeCH_TwoSO_Two, 3-
Cl-PhCHMeCH_TwoSO_Two, 4-Cl-PhCHMeCH_TwoSO_Two, 2,4-Cl_Two-PhCHMe
CH_TwoSO_Two, 3,5-Cl_Two-PhCHMeCH_TwoSO_Two, 2,6-Cl_Two-PhCHMeCH_TwoS
O_Two, 2,3-Cl_Two-PhCHMeCH_TwoSO_Two, 2,5-Cl_Two-PhCHMeCH_TwoSO_Two, 2-
F-PhCHMeCH_TwoSO_Two, 3-F-PhCHMeCH_TwoSO_Two, 4-F-PhCHMeCH_TwoS
O_Two, 2-F-4-Cl-PhCHMeCH_TwoSO_Two, 2-Br-PhCHMeCH_TwoSO_Two, 3-Br
-PhCHMeCH_TwoSO_Two, 4-Br-PhCHMeCH_TwoSO_Two, 2-Me-PhCHMeCH_TwoS
O_Two, 3-Me-PhCHMeCH_TwoSO_Two, 4-Me-PhCHMeCH_TwoSO_Two, PhCH_TwoCH
(Me) SO_Two, 2-Cl-PhCH_TwoCH (Me) SO_Two, 3-Cl-PhCH_TwoCH (Me) SO_Two,
 4-Cl-PhCH _TwoCH (Me) SO_Two, 2,4-Cl_Two-PhCH_TwoCH (Me) SO_Two, 3,5-
Cl_Two-PhCH_TwoCH (Me) SO_Two, 2,6-Cl_Two-PhCH _TwoCH (Me) SO_Two, 2,3-Cl
_Two-PhCH_TwoCH (Me) SO_Two, 2,5-Cl_Two-PhCH_TwoCH (Me) SO_Two, 2-F-PhCH
_TwoCH (Me) SO_Two, 3-F-PhCH_TwoCH (Me) SO_Two, 4-F-PhCH_TwoCH (Me) S
O_Two, 2-F-4-Cl-PhCH_TwoCH (Me) SO_Two, 2-Br-PhCH_TwoCH (Me) SO_Two, 3
-Br-PhCH_TwoCH (Me) SO_Two, 4-Br-PhCH_TwoCH (Me) SO_Two, 2-Me-PhCH
_TwoCH (Me) SO_Two, 3-Me-PhCH_TwoCH (Me) SO_Two, 4-Me-PhCH_TwoCH (Me) S
O_Two, PhCMe_TwoSO_Two, PhCHMeCH (Me) SO_Two, PhCH_TwoCH_TwoCH_TwoSO_Two, Ph
CH_TwoCH_TwoCH_TwoCH_TwoSO_Two, PhCH_TwoCH_TwoCH_TwoCH_TwoCH_TwoSO_Two, PhCH _TwoCH_TwoCH_Two
CH_TwoCH_TwoCH_TwoSO_Two,

PhSO ₂ , 2-Cl-PhSO ₂ , 3-Cl-PhSO ₂ , 4-Cl-Ph
SO ₂ , 2,4-Cl ₂ -PhSO ₂ , 3,5-Cl ₂ -PhSO ₂ , 2,6-Cl ₂ -PhSO ₂ ,
2,3-Cl ₂ -PhSO ₂ , 2,5-Cl ₂ -PhSO ₂ , 2-F-PhSO ₂ , 3-F-PhS
O ₂ , 4-F-PhSO ₂ , 2-F-4-Cl-PhSO ₂ , 2-Br-PhSO ₂ , 3-Br-Ph
SO ₂ , 4-Br-PhSO ₂ , 2-Me-PhSO ₂ , 3-Me-PhSO ₂ , 4-Me-PhSO
₂ , 2,4-Me ₂ -PhSO ₂ , 3,5-Me ₂ -PhSO ₂ , 2,6-Me ₂ -PhSO ₂ , 2,
3-Me ₂ -PhSO ₂ , 2,5-Me ₂ -PhSO ₂ , 2-MeO-PhSO ₂ , 3-MeO-PhS
O ₂ , 4-MeO-PhSO ₂ , 2-CF ₃ -PhSO ₂ , 3-CF ₃ -PhSO ₂ , 4-CF ₃ -P
hSO ₂ , 2,4,6-Cl ₃ -PhSO ₂ , 2,3,5-Cl ₃ -PhSO ₂ , 2,3,4-Cl _3-
PhSO ₂ , 2-NO ₂ -PhSO ₂ , 3-NO ₂ -PhSO ₂ , 4-NO ₂ -PhSO ₂ , 2,4-
(NO ₂ ) ₂ -PhSO ₂ , 2-CN-PhSO ₂ , 3-CN-PhSO ₂ , 4-CN-PhSO ₂ ,

CH_TwoNMe_Two, CH_TwoNEt_Two, CH_TwoN (Pr-n)_Two, CH_TwoNPR
-iso)_Two, CH_TwoN (Bu-n)_Two, CH_TwoN (Bu-iso)_Two, CH_TwoN (Bu-sec)_Two,
 CH_TwoNEtMe, CH_TwoNMePr-n, CH_TwoNMePr-iso, CH_TwoNMeBu-n, C
H_TwoNMeBu-iso, CH_TwoNMeBu-sec, CH_TwoNMeBu-tert, CH_TwoNMePe
n-n, CH_TwoNMeHex-n, CH_TwoNMeHep-n, CH_TwoNMeOct-n, CH_TwoCH_Two
NMe_Two, CH_TwoCH_TwoNEt_Two, CH_TwoCH_TwoN (Pr-n)_Two, CH_TwoCH_TwoN (Pr-is
o)_Two, CH_TwoCH_TwoN (Bu-n)_Two, CH_TwoCH_TwoN (Bu-iso)_Two, CH_TwoCH_TwoN (Bu-
sec)_Two, CH_TwoCH_TwoNEtMe, CH_TwoCH _TwoNMePr-n, CH_TwoCH_TwoNMePr-is
o, CH_TwoCH_TwoNMeBu-n, CH_TwoCH_TwoNMeBu-iso, CH_TwoCH_TwoNMeBu-se
c, CH_TwoCH_TwoNMeBu-tert, CH_TwoCH_TwoNMePen-n, CH_TwoCH_TwoNMeHex-
n, CH_TwoCH_TwoNMeHep-n, CH _TwoCH_TwoNMeOct-n,

[0124]

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[0125]

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NMe ₂ , NEt ₂ , N (Pr-n) ₂ , N (Pr-iso) ₂ , N (Bu
-n) ₂ , N (Bu-iso) ₂ , N (Bu-sec) ₂ , NEtMe, NMePr-n, NMeP
r-iso, NMeBu-n, NMeBu-iso, NMeBu-sec, NMeBu-tert,
NMePen-n, NMeHex-n, NMeHep-n, NMeOct-n,

[0127]

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CONMe ₂ , CONEt ₂ , CON (Pr-n) ₂ , CON (Pr-is
o) ₂ , CON (Bu-n) ₂ , CON (Bu-iso) ₂ , CON (Bu-sec) ₂ , CONEt
Me, CONMePr-n, CONMePr-iso, CONMeBu-n, CONMeBu-is
o, CONMeBu-sec, CONMeBu-tert, CONMePen-n, CONMeHex
-n, CONMeHep-n, CONMeOct-n,

[0129]

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SO ₂ NMe ₂ , SO ₂ NEt ₂ , SO ₂ N (Pr-n) ₂ , SO ₂ N (Pr
-iso) ₂ , SO ₂ N (Bu-n) ₂ , SO ₂ N (Bu-iso) ₂ , SO ₂ N (Bu-sec) ₂ ,
SO ₂ NEtMe, SO ₂ NMePr-n, SO ₂ NMePr-iso, SO ₂ NMeBu-n, S
O ₂ NMeBu-iso, SO ₂ NMeBu-sec, SO ₂ NMeBu-tert, SO ₂ NMePe
nn, SO ₂ NMeHex-n, SO ₂ NMeHep-n, SO ₂ NMeOct-n,

[0131]

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Ph, 2-Cl-Ph, 3-Cl-Ph, 4-Cl-Ph, 2,4-Cl ₂
-Ph, 3,5-Cl ₂ -Ph, 2,6-Cl ₂ -Ph, 2,3-Cl ₂ -Ph, 2,5-Cl ₂ -P
h, 2-F-Ph, 3-F-Ph, 4-F-Ph, 2-F-4-Cl-Ph, 2-Br-Ph, 3
-Br-Ph, 4-Br-Ph, 2-Me-Ph, 3-Me-Ph, 4-Me-Ph, 2,4-Me
₂ -Ph, 3,5-Me ₂ -Ph, 2,6-Me ₂ -Ph, 2,3-Me ₂ -Ph, 2,5-Me _2-
Ph, 2-MeO-Ph, 3-MeO-Ph, 4-MeO-Ph, 2-CF ₃ -Ph, 3-CF _3-
Ph, 4-CF ₃ -Ph, 2,4,6-Cl ₃ -Ph, 2,3,5-Cl ₃ -Ph, 2,3,4-Cl
₃ -Ph, 2-NO ₂ -Ph, 3-NO ₂ -Ph, 4-NO ₂ -Ph, 2,4- (NO ₂ ) ₂ -Ph,
2-CN-Ph, 3-CN-Ph, 4-CN-Ph, 3,5- (CF ₃ ) ₂ -Ph, 4- (PhSO
₂ ) -Ph, 4- (4-Cl-Ph) -Ph, 4- (4-CF ₃ -Ph) -Ph, 1-Naph, 2-
Naph, Q1, Q2, Q3, Q4, Q5, Q6, Q7, Q8, Q9, Q10, Q1
1, Q12, Q13, Q14, Q15, Q16, Q17, Q18, Q19, Q20, Q2
1, Q22, Q23, Q24, Q25, Q26, Q27, Q28, Q29, Q30, Q3
1, Q32, Q33, Q34, Q35, Q36, Q37, Q38, Q39, Q40, Q4
1, Q42, Q43, Q44, Q45, Q46, Q47, Q48, Q49, Q50, Q5
1, Q52, Q53, Q54, Q55, Q56, Q57, Q58, Q59, Q60, Q6
1, Q62, Q63, Q64, Q65, Q66, Q67, Q68, Q69, Q70, Q7
1, Q72, Q73, Q74, Q75, Q76, Q77, Q78, Q79, Q80, Q8
1, Q82, Q83, Q84, Q85, Q86, Q87, Q88, Q89, Q90, Q9
1, Q92, Q93, Q94, Q95, Q96, Q97, Q98, Q99, Q100, Q
101, Q102, Q103, Q104, Q105, Q106, Q107, Q108, Q10
9, Q110, Q111, Q112, Q113, Q114, Q115, Q116, Q117,
Q118, Q119, Q120, Q121, Q122, Q123, Q124, Q125, Q
126, Q127, Q128, Q129, Q130, Q131, Q132, Q133, Q13
4, Q135, Q136, Q137, Q138, Q139, Q140, Q141, Q142,
Q143, Q144, Q145, Q146, Q147, Q148, Q149, Q150,

Q1-CH ₂ , Q2-CH ₂ , Q3-CH ₂ , Q4-CH ₂ , Q5-C
H ₂ , Q6-CH ₂ , Q7-CH ₂ , Q8-CH ₂ , Q9-CH ₂ , Q10-CH ₂ , Q11-CH
₂ , Q12-CH ₂ , Q13-CH ₂ , Q14-CH ₂ , Q15-CH ₂ , Q16-CH ₂ , Q1
7-CH ₂ , Q18-CH ₂ , Q19-CH ₂ , Q20-CH ₂ , Q21-CH ₂ , Q22-CH ₂ ,
Q23-CH ₂ , Q24-CH ₂ , Q25-CH ₂ , Q26-CH ₂ , Q27-CH ₂ , Q28-C
H ₂ , Q29-CH ₂ , Q30-CH ₂ , Q31-CH ₂ , Q32-CH ₂ , Q33-CH ₂ , Q3
4-CH ₂ , Q35-CH ₂ , Q36-CH ₂ , Q37-CH ₂ , Q38-CH ₂ , Q39-C
H ₂ , Q40-CH ₂ , Q41-CH ₂ , Q42-CH ₂ , Q43-CH ₂ , Q44-CH ₂ , Q4
5-CH ₂ , Q46-CH ₂ , Q47-CH ₂ , Q48-CH ₂ , Q49-CH ₂ , Q50-CH ₂ ,
Q51-CH ₂ , Q52-CH ₂ , Q53-CH ₂ , Q54-CH ₂ , Q55-CH ₂ , Q56-
CH ₂ , Q57-CH ₂ , Q58-CH ₂ , Q59-CH ₂ , Q60-CH ₂ , Q61-CH ₂ , Q
62-CH ₂ , Q63-CH ₂ , Q64-CH ₂ , Q65-CH ₂ , Q66-CH ₂ , Q67-C
H ₂ , Q68-CH ₂ , Q69-CH ₂ , Q70-CH ₂ , Q71-CH ₂ , Q72-CH ₂ , Q
73-CH ₂ , Q74-CH ₂ , Q75-CH ₂ , Q76-CH ₂ , Q77-CH ₂ , Q78-C
_{H 2, Q79-CH 2,} Q80-CH 2, Q81-CH 2, Q82-CH 2, Q83-CH 2, Q8
4-CH ₂ , Q85-CH ₂ , Q86-CH ₂ , Q87-CH ₂ , Q88-CH ₂ , Q89-C
H ₂ , Q90-CH ₂ , Q91-CH ₂ , Q92-CH ₂ , Q93-CH ₂ , Q94-CH ₂ , Q9
5-CH ₂ , Q96-CH ₂ , Q97-CH ₂ , Q98-CH ₂ , Q99-CH ₂ , Q100-C
H ₂ , Q101-CH ₂ , Q102-CH ₂ , Q103-CH ₂ , Q104-CH ₂ , Q105-C
H ₂ , Q106-CH ₂ , Q107-CH ₂ , Q108-CH ₂ , Q109-CH ₂ , Q110-C
_{H 2, Q111-CH 2,} Q112-CH 2, Q113-CH 2, Q114-CH 2, Q115-C
H ₂ , Q116-CH ₂ , Q117-CH ₂ , Q118-CH ₂ , Q119-CH ₂ , Q120-C
H ₂ , Q121-CH ₂ , Q122-CH ₂ , Q123-CH ₂ , Q124-CH ₂ , Q125-C
H ₂ , Q126-CH ₂ , Q127-CH ₂ , Q128-CH ₂ , Q129-CH ₂ , Q130-CH
_{2, Q131-CH 2, Q132} -CH 2, Q133-CH 2, Q134-CH 2, Q135-CH
_{2, Q136-CH 2, Q137} -CH 2, Q138-CH 2, Q139-CH 2, Q140-CH
₂ , Q141-CH ₂ , Q142-CH ₂ -CH ₂ , Q143-CH ₂ , Q144-CH ₂ , Q59
-O, Q60-O, Q61-O, Q62-O, Q63-O, Q64-O, Q65-O, Q66-
O, Q67-O, Q68-O, Q69-O, Q70-O, Q71-O, Q101-O, Q102
-O, Q103-O, Q104-O, Q105-O, Q106-O, Q107-O, Q108-
O, Q109-O, Q110-O, Q111-O, Q112-O, Q113-O, Q114-O,
Q115-O, Q116-O, Q117-O, Q118-O, Q59-S, Q60-S, Q61-
S, Q62-S, Q63-S, Q64-S, Q65-S, Q66-S, Q67-S, Q68-
S, Q69-S, Q70-S, Q71-S, Q101-S, Q102-S, Q103-S, Q1
04-S, Q105-S, Q106-S, Q107-S, Q108-S, Q109-S, Q110
-S, Q111-S, Q112-S, Q113-S, Q114-S, Q115-S, Q116-
S, Q117-S, Q118-S Further, examples of compounds included in the present invention are shown in Table 5,
It is not particularly limited to these.

[Table 5]

[0135]

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[0136]

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[0137]

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[0138]

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[0139]

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[0140]

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[0141]

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[0142]

[Table 14] ────────────────────── R ² R ³ ──────────────────── ── Me Et Me Pr-n Me Pr-iso Me Bu-iso Me Bu-sec Me Bu-tert Me CHMeCHMe ₂ Me Pen-n Me Hex-iso Me Pr-cyc Me Bu-cyc Me CH ₂ Pr-cyc Me CH ₂ Bu-cyc Me CH ₂ Pen-cyc Me CH ₂ Hex-cyc Me CH ₂ CH ₂ Pr-cyc Me CH ₂ CH = CHMe Me CH ₂ CH ₂ CH = CH ₂ Me CH ₂ C≡CMe Me CH ₂ OMe Me CH ₂ OEt Me CH ₂ OPr-n Me CH ₂ OBu-n ──────────────────────

[0143]

[Table 15] ────────────────────── R ² R ³ ──────────────────── ── Me CH ₂ OBu-iso Me CH ₂ OBu-sec Me CH ₂ OBu-tert Me CH ₂ CH ₂ OMe Me CH ₂ CH ₂ OEt Me CH ₂ CH ₂ OPr-n Me CH ₂ CH ₂ CH ₂ OMe Me CH ₂ CH ₂ CH ₂ OEt Me CH ₂ CH ₂ CH ₂ CH ₂ OMe Me 2-Cl-Ph Me 3-Cl-Ph Me 4-Cl-Ph Me 2,4-Cl ₂ -Ph Me 3,5-Cl ₂ -Ph Me 2,6-Cl ₂ -Ph Me 2,3-Cl ₂ -Ph Me 2,5-Cl ₂ -Ph Me 2-F-Ph Me 3-F-Ph Me 4-F-Ph Me 2- F-4-Cl-Ph Me 2-Br-Ph Me 3-Br-Ph ──────────────────────

[0144]

[Table 16] ────────────────────── R ² R ³ ──────────────────── ── Me 4-Br-Ph Me 2-Me-Ph Me 3-Me-Ph Me 4-Me-Ph Me 2,4-Me ₂ -Ph Me 3,5-Me ₂ -Ph Me 2,6-Me ₂ -Ph Me 2,3-Me ₂ -Ph Me 2,5-Me ₂ -Ph Me 2-MeO-Ph Me 3-MeO-Ph Me 4-MeO-Ph Me 2-CF ₃ -Ph Me 3-CF ₃ -Ph Me 4-CF ₃ -Ph Me 2,4,6-Cl ₃ -Ph Me 2,3,5-Cl ₃ -Ph Me 2,3,4-Cl ₃ -Ph Me 2-NO ₂ -Ph Me 3-NO ₂ -Ph Me 4-NO ₂ -Ph Me 2-CN-Ph Me 3-CN-Ph ──────────────────────

[0145]

[Table 17] ────────────────────── R ² R ³ ──────────────────── ── Me 4-CN-Ph Me CH ₂ Ph Me OMe Me OEt Me OPr-n Me OBu-n Me OBu-iso Me OBu-sec Me OBu-tert Et Pr-iso Et Bu-n Et Bu-iso Et Bu -sec Et Bu-tert Et CHMeCHMe ₂ Et Pen-n Et Hex-n Et Hex-iso Et Hex-cyc Et Pr-cyc Et Bu-cyc Et CH ₂ Pr-cyc Et CH ₂ Bu-cyc ───── ─────────────────

[0146]

[Table 18] ────────────────────── R ² R ³ ──────────────────── ── Et CH ₂ Pen-cyc Et CH ₂ Hex-cyc Et CH ₂ CH ₂ Pr-cyc Et CH ₂ CH = CH ₂ Et CH ₂ CH = CHMe Et CH ₂ CH ₂ CH = CH ₂ Et CH ₂ C≡CH Et Ph Pr-n Pr-n Pr-n Bu-n Pr-n Pen-n Pr-n Hex-n Pr-n CH ₂ CH = CH ₂ Pr-n CH ₂ C≡CH Bu-n Bu-n Bu -n Pen-n Bu-n Hex-n Bu-n CH ₂ CH = CH ₂ Bu-n CH ₂ C≡CH CH ₂ CH = CH ₂ CH ₂ C≡CH Me CH ₂ SMe Me CH ₂ SEt Me CH ₂ SPr-n ──────────────────────

[0147]

[Table 19] ────────────────────── R ² R ³ ──────────────────── ── Me CH ₂ SBu-n Me CH ₂ SBu-iso Me CH ₂ SBu-sec Me CH ₂ SBu-tert Me CH ₂ CH ₂ SMe Me CH ₂ CH ₂ SEt Me CH ₂ CH ₂ SPr-n Me CH ₂ CH ₂ CH ₂ SMe Me CH ₂ CH ₂ CH ₂ SEt Me CH ₂ CH ₂ CH ₂ CH ₂ SMe Pr-iso 2-Cl-Ph Pr-iso 3-Cl-Ph Pr-iso 4-Cl-Ph Pr-iso 2 , 4-Cl ₂ -Ph Pr-iso 3,5-Cl ₂ -Ph Pr-iso 2,6-Cl ₂ -Ph Pr-iso 2,3-Cl ₂ -Ph Pr-iso 2,5-Cl _2- Ph Pr-iso 2-F-Ph Pr-iso 3-F-Ph Pr-iso 2-F-4-Cl-Ph Pr-iso 2-Br-Ph Pr-iso 3-Br-Ph ───── ─────────────────

[0148]

[Table 20] ────────────────────── R ² R ³ ──────────────────── ── Pr-iso 4-Br-Ph Pr-iso 2-Me-Ph Pr-iso 3-Me-Ph Pr-iso 4-Me-Ph Pr-iso 2,4-Me ₂ -Ph Pr-iso 3, 5-Me ₂ -Ph Pr-iso 2,6-Me ₂ -Ph Pr-iso 2,3-Me ₂ -Ph Pr-iso 2,5-Me ₂ -Ph Pr-iso 2-MeO-Ph Pr-iso 3-MeO-Ph Pr-iso 4-MeO-Ph Pr-iso 2-CF ₃ -Ph Pr-iso 3-CF ₃ -Ph Pr-iso 4-CF ₃ -Ph Pr-iso 2,4,6-Cl ₃ -Ph Pr-iso 2,3,5-Cl ₃ -Ph Pr-iso 2,3,4-Cl ₃ -Ph Pr-iso 2-NO ₂ -Ph Pr-iso 3-NO ₂ -Ph Pr-iso 4-NO ₂ -Ph Pr-iso 2-CN-Ph Pr-iso 3-CN-Ph ──────────────────────

[0149]

[Table 21] ────────────────────── R ² R ³ ──────────────────── ── Pr-iso 4-CN-Ph Pr-iso CH ₂ Ph ──────────────────────

Continuing from Table 5, examples of forming a ring together with the nitrogen atom to which R ² and R ³ are bonded are described below.

[0151]

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[0152]

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Although the amount of carbamoyltetrazole applied as a herbicide varies depending on the application scene, application time, application method, target weeds, cultivated crops, etc., it is generally 0.001 to 0.001 per hectare (ha) as an active ingredient. About 50 kg, preferably about 0.01 to 10 kg is appropriate. Carbamoyltetrazole can be used as a herbicide for paddy fields in any of soil treatment and foliage treatment under flooding. Examples of paddy weeds include paddy weeds ( Alisma canaliculatum ), pokeweeds ( Sagittaria trifolia ) and urikawa ( Sagittari ).
Alismataceae family, which is represented by a pygmaea), etc. (Alismatacea
e) weeds, smallflower umbrellaplant (Cyperus difformis), Cyperus (Cyperus serotinus), bulrush (Scirpus jun
coides ) and Cyperaceae weeds such as Eleocharis kuroguwai , Scrothulariaceae weeds such as Lindemia pyxidaria , and Monochoria vagin
pontederiaceae represented by alis) (Potenderiaceae) weed, pondweed (potamogetonaceae represented by Potamogeton distinctus) (Potamogetonaceae) weeds, Lythraceae represented by Rotala indica (Rotala indica) (Lythracea
e) Weeds and Gramineae weeds represented by Echinochloa crus-galli .

The carbamoyltetrazole can be used as a herbicide for upland fields in any of soil treatment, soil admixture treatment and foliage treatment.
In addition to agricultural or horticultural fields such as orchards, the present invention can be applied to the control of various weeds on non-cultivated lands such as athletic fields, open spaces, and track ends. If necessary, carbamoyltetrazole may be mixed and applied with other kinds of herbicides, various insecticides, fungicides, plant growth regulators, synergists and the like at the time of preparation or spraying.

In particular, by mixing and applying other herbicides, it is possible to expect a reduction in cost due to a decrease in the amount of applied medicine, an increase in the herbicidal spectrum due to the synergistic action of the mixed chemicals, and a higher herbicidal effect. At this time, a combination with a plurality of known herbicides is also possible at the same time. Preferred herbicides to be used in combination with carbamoyltetrazole include, for example, pyrazosulfuron ethyl (pyrazosulfuron ethyl / generic name), bensulfuron methyl (bensulfuron methyl / generic name), sinosulfuron (cinosulfuron / generic name), imazosulfuron / Generic name), azimsulfuron (azimsulfuron / generic name), halosulfuron methyl (halosulfuron methyl / generic name), pretilachlor (pretilachlor / generic name), esprocarb (esprcarb)
ocarb / generic name, pyrazolate (pyrazolate / generic name), pyrazoxyfen (pyrazoxyfen / generic name), benzofenap (benzofenap / generic name), daimuron (daimuron / generic name), bromobutide /
Generic name), naproanilide (naproanilide / generic name),
Clomeprop (generic name), CNP (generic name), chlomethoxynil (generic name),
Bifenox (common name), oxadiazon (oxadiazon / common name),

Oxaziargyl (generic name), cafenstrole (cafenstrole / generic name), MY-100 (test name), MK-243 (test name), KPP-314 (test name), KUH-920
(Test name), DEH-112 (test name), NBA-061 (test name),
Mefenacet (mefenacet / generic name), butachlor (butachlor / generic name), butenachlor (butenachlor)
/ Generic name), dithiopyl (generic name), benfresate (benfuresate / generic name), pyributicarb (pyributicarb / generic name), benthiocarb (benthioc)
arb / generic name), dimepiperate (generic name), molinate (molinate / generic name), butamifos (butamifos / generic name), quinclorac
/ Generic name), cinmethrin (cinmethylin / generic name),
Simetryn (simetryn / common name), bensulide (bensul
ide / generic name), dimethametryn (dimethametryn / generic name), MCPA, MCPB, etobenzani
d), cumyluron (common name), tenylchlor (thenylchlor / common name), cyclosulfamuron (c
yclosulfamuron / generic name), ethoxysulfuron (etho)
xysulfuron / generic name), anilofos (anilofos / generic name), cyhalofop butyl (cyhalofop butyl / generic name), pyriminobac methyl (pyriminobac methyl / generic name), pentoxazone (pentoxazone / generic name), oxadiclomefone / oxaziclomefone / Common name), benzobicyclon (common name) and ACN (common name).

When carbamoyltetrazole is applied as a herbicide, it is generally mixed with a suitable solid carrier or liquid carrier, and if necessary, a surfactant, a penetrant, a spreading agent, a thickener, a deicing agent, A binder, an anti-caking agent or an anti-decomposition agent is added, and the composition can be put to practical use in any form such as a liquid, emulsion, wettable powder, dry flowable, flowable, powder or granule.

In addition, from the viewpoint of labor saving and improvement of safety,
The preparation of any of the above dosage forms can also be provided in a water-soluble package. Examples of solid carriers include natural minerals such as kaolinite, pyrophyllite, sericite, talc, bentonite, acid clay, attapulgite, zeolite and diatomaceous earth, inorganic salts such as calcium carbonate, ammonium sulfate, sodium sulfate and potassium chloride; Synthetic silicic acid, synthetic silicate, and the like are included.

Examples of the liquid carrier include water, alcohols (eg, ethylene glycol, propylene glycol, isopropanol), aromatic hydrocarbons (eg, xylene, alkylbenzene, alkylnaphthalene), ethers (eg, butyl cellosolve), and ketones (eg, cyclohexanone). And the like, esters (γ-butyrolactone, etc.), acid amides (N-methylpyrrolidone, N-octylpyrrolidone, etc.) and vegetable oils (soybean oil, rapeseed oil, cottonseed oil, castor oil, etc.).

These solid and liquid carriers may be used alone or in combination of two or more. As a surfactant,
For example, polyoxyethylene alkyl aryl ether,
Nonionic surfactants such as polyoxyethylene styryl phenyl ether, polyoxyethylene polyoxypropylene block copolymer, polyoxyethylene fatty acid ester, sorbitan fatty acid ester and polyoxyethylene sorbitan fatty acid ester, and alkylbenzene sulfonate, lignin sulfonic acid Salt, alkyl sulfosuccinate, naphthalene sulfonate, alkyl naphthalene sulfonate, salt of formalin condensate of naphthalene sulfonic acid, salt of formalin condensate of alkyl naphthalene sulfonic acid, polyoxyethylene alkyl aryl ether sulfate and phosphate, Polyoxyethylene styryl phenyl ether sulfate and ionic surfactants such as phosphates and alkylamine salts.

The content of these surfactants is not particularly limited, but is preferably in the range of usually 0.05 to 20 parts by weight based on 100 parts by weight of the preparation of the present invention. These surfactants may be used alone or in combination of two or more. Next, a formulation example of a preparation when carbamoyltetrazole is used will be described. However, the composition examples of the present invention are not limited to these. In the following formulation examples, "parts" means parts by weight.

Wetting agent carbamoyltetrazole 0.1 to 80 parts Solid carrier 5 to 98.9 parts Surfactant 1 to 10 parts Others 0 to 5 parts Other examples include anti-caking agents and decomposition inhibitors.

Emulsion carbamoyltetrazole 0.1-30 parts Liquid carrier 55-95 parts Surfactant 4.9-15 parts

Flowable agent Carbamoyltetrazole 0.1 to 70 parts Liquid carrier 15 to 98.89 parts Surfactant 1 to 12 parts Others 0.01 to 30 parts Others include, for example, an antifreezing agent and a thickener.

Dry flowable agent Carbamoyltetrazole 0.1 to 90 parts Solid carrier 0 to 98.9 parts Surfactant 1 to 20 parts Others 0 to 10 parts Others include, for example, a binder and a decomposition inhibitor.

Liquid Carbamoyltetrazole 0.01 to 30 parts Liquid carrier 0.1 to 50 parts Water 50 to 99.89 parts Others 0 to 10 parts Others include, for example, antifreezing agents and spreading agents.

Granules Carbamoyltetrazole 0.01 to 10 parts Solid carrier 90 to 99.99 parts Others 0 to 10 parts Others include, for example, binders and decomposition inhibitors.

For use, the above preparation is sprayed as it is or after diluting it with water 1 to 10,000 times.

[0169]

【Example】

Formulation Examples Next, specific examples of agrochemical formulations containing carbamoyltetrazole as an active ingredient will be shown, but the invention is not limited thereto. . In the following formulation examples, "parts" means parts by weight.

Formulation Example 1 Wettable powder carbamoyltetrazole No. 1a-1 20 parts Pyrophyllite 76 parts Solpol 5039 2 parts (mixture of nonionic surfactant and anionic surfactant: Toho Chemical Industry Co., Ltd. (Trade name) Carplex # 80 2 parts (synthetic hydrated silica: trade name of Shionogi & Co., Ltd.) The above is uniformly mixed and pulverized to obtain a wettable powder.

[Formulation Example 2] Emulsion carbamoyltetrazole No. 1a-1 5 parts Xylene 75 parts N-methylpyrrolidone 15 parts Solpol 2680 5 parts (mixture of nonionic surfactant and anionic surfactant: Toho The above are mixed uniformly to form an emulsion.

[Formulation Example 3] Flowable agent Carbamoyltetrazole No. 1a-1 25 parts Agrisol S-710 10 parts (Nonionic surfactant: trade name of Kao Corporation) Lunox 1000C 0.5 part (Anionic interface) Activator: Toho Chemical Industry Co., Ltd.) Xanthan gum 0.02 parts Water 64.48 parts After uniformly mixing, wet pulverize to obtain a flowable agent.

[Formulation Example 4] Dry flowable agent Carbamoyltetrazole No. 1a-1 75 parts Hytenol NE-15 5 parts (anionic surfactant: trade name of Daiichi Kogyo Seiyaku Co., Ltd.) Vanirex N 10 parts (anion Surfactant: Nippon Paper Industries Co., Ltd.) Carplex # 80 10 parts (Synthetic hydrated silicic acid: Shionogi & Co., Ltd.) After uniformly mixing and pulverizing the above, a small amount of water is added, followed by stirring and mixing. It is kneaded, granulated by an extrusion granulator, and dried to obtain a dry flowable agent.

[Compounding Example 5] Granules Carbamoyltetrazole No. 1a-1 1 part Bentonite 55 parts Talc 44 parts After uniformly mixing and pulverizing the above, a small amount of water was added, followed by stirring, mixing and kneading, followed by extrusion granulation. Granulate with a machine and dry to make granules.

Formulation Example 6 Granules Carbamoyltetrazole No. 1a-1 1 part Compound (A) 0.07 part DBSN 3 parts Epoxidized soybean oil 1 part Bentonite 30 parts Talc 64.93 parts The above components are uniformly mixed and pulverized. After that, a small amount of water is added, and the mixture is kneaded by stirring, kneaded, granulated by an extrusion granulator, and dried to obtain granules.

The compound (A) may be pyrazosulfuron ethyl (general name), DBS
N means sodium dodecylbenzenesulfonate. Test Examples Next, the usefulness of carbamoyltetrazole as a herbicide will be specifically described in the following test examples.

[Test Example 1] Test on herbicidal effect by pretreatment of emergence of weeds under flooded conditions. After placing alluvial soil in a 1 / 5000-are Wagner pot, water was added and mixed to obtain a flooded condition at a depth of 4 cm. .
After seeding each of the seeds of Nobie, Firefly, Konagi and Kikashigusa in the above pot, rice seedlings at the 2.5 leaf stage were transplanted. The pot is placed in a greenhouse at 25 to 30 ° C. to grow the plant, and a carbamoyltetrazole wettable powder adjusted according to Formulation Example 1 is added to water on the first day after sowing so that the water level becomes a predetermined amount. And diluted. Three weeks after the treatment, the herbicidal effect on rice and various weeds was investigated. 0 is no effect and 5 is a 5-point scale showing complete withering. The results are shown in Table 6.

[Test Example 2] Herbicidal effect test by weed growing season treatment under flooded conditions 1/5000 arel Wagner pot was put into alluvial soil, water was added and mixed, and the water depth was 4 cm. .
The seeds of each of Nobie, Firefly, Konagi and Kikashigusa were mixed and sown in the above pot. The pot was placed in a greenhouse at 25 to 30 ° C. to grow the plant, and when Nobie, Firefly, Konagi and Kikasigusa reached the 1-2 leaf stage, the formulation amount was adjusted to the prescribed amount on the water surface. The carbamoyltetrazole wettable powder prepared according to the above procedure was diluted with water and treated.
Three weeks after the treatment, the herbicidal effect on various weeds was investigated according to the criteria of Test Example 1. The results are shown in Table 7.

[Test Example 3] Herbicidal effect test by soil treatment Put sterilized laid soil in a plastic box 21 cm long, 13 cm wide and 7 cm deep, and spot the seeds of lobster, enokorogosa, corn, soybean and cotton. After the seeds were sowed and covered with about 1.5 cm of soil, they were evenly sprayed on the soil surface with a small spray so that the amount of the active ingredient became a predetermined ratio. As a chemical solution at the time of spraying, a wettable powder appropriately adjusted according to Formulation Example 1 was used by diluting with water, and this was sprayed over the entire surface. Three weeks after spraying the chemical solution, the herbicidal effect on the plants was investigated in accordance with the criteria of Test Example 1. The results are shown in Table 8.

The symbols in the tables have the following meanings. A (Nobie), B (Enokorogosa), C (Firefly),
D (Eel), E (Europea), a (corn), b (soybean), c (cotton), d (transplanted rice)

[0181]

[Table 6] 化合物 Compound treatment dose AC D Ed No. g / a １ 1a-1 10 5 5 5 5 0 1a-2 10 5 5 5 5 0 1a-3 10 3 4 5 5 0 1 a-4 10 5 5 5 5 5 0 1 a-5 10 5 5 5 5 0 1 a-6 10 5 5 5 5 5 3 1 a-7 10 5 5 5 5 0 5 a 1-8 10 5 5 5 5 5 2 5 a 1 a -9 10 5 5 5 5 0 1a-10 10 5 5 5 5 5 0 1a-11 10 4 2 2 0 1 0 1a-12 10 5 5 5 5 5 0 1a-13 10 5 4 5 5 5 0 1a-14 10 5 5 5 5 0 1 a-15 10 4 2 5 4 0 1 a-16 10 5 5 5 5 0 1 a-17 10 5 5 5 5 0 5 1 a-18 10 5 5 5 5 5 0 1 −20 10 5 5 5 5 0 1a-21 10 5 5 5 5 5 0 1a-22 10 5 0 5 5 5 0} ───

[0182]

[Table 23] [Continued from Table 6] ─────────────────────────── Compound Treatment dose AC D E d No. g / a ─────────────────────────── 1a-23 10 5 5 5 5 0 1a-24 10 5 5 5 5 0 1a-25 10 5 3 4 5 0 1a-26 10 5 5 5 5 0 1a-27 10 5 5 5 5 5 0 1a-28 10 5 5 5 5 0 1a-29 2.52 5 3 5 5 0 1a-30 10 5 5 5 5 5 0 1a-31 10 5 5 5 5 5 0 1a-32 10 5 5 5 5 5 0 1a-37 10 5 5 5 5 0 1a-38 10 5 5 5 5 1 1a-39 10 5 5 5 0 1a-40 10 5 5 5 5 0 1a-41 10 5 5 5 0 1a-43 10 5 5 5 0 1a-44 10 5 5 5 0 1a-45 10 5 5 5 0 1 -46 10 5 5 5 0 1a-47 10 5 5 5 5 0 1a-48 10 5 5 5 1}

[0183]

[Table 24] [Continued from Table 6] Compound treatment dose AC D No. g / a ─────────────────────────── 1a-49 10 5 5 5 0 1a-50 10 5 5 5 5 0 1a-51 10 5 5 500 1b-1 10 500 0 00 1b-3 10 5 5 5 5 5 0 5 1 5 4 5 5 5 5 5 0 1b-5 10 5 4 3 3 0 1b-6 10 5 5 5 5 0 1b-7 10 0 3 3 2 0 1b-8 10 5 2 0 0 0 1b-9 10 5 5 5 5 5 0 1b-10 10 2 2 3 2 0 1b-11 1 10 5 5 5 5 0 1b-18 10 5 5 5 5 0 1b-19 20 55 55 ───────────────────────────

[0184]

[Table 25]

[0185]

[Table 26]

[0186]

[Table 27]

[0187]

[Table 28] 化合物 Compound treatment dose A B abc No. g / a １ 1a-1 255 5500 0a 1a-2 255 5500 1a-4 255 400 000 1a-5 254 1 000 1a-6 525 5 000 000 1a-7 525 000 000 001 aa 825 5 550 001 3a-9 525 550 000 001 -10 25 55 00 00 1a-11 25 55 00 00 1a-12 25 25 00 00 0 1a-13 25 55 100 0 0 1a-14 25 55 100 00 1a-16 25 55 55 0 0 0 1a-17 25 4 0 0 0 0 1a-23 25 5 500 0 0 0 1a-24 25 5 4 0 0 0 1a-25 25 5 5 5 0 0 0 0 a-26 25 33 00 0 1a-27 25 55 300 0 1a-28 25 55 400 0} ────

[0188]

Table 29 [Continued in Table 8] 処理 Compound treatment dose A Babc No. g / a ─────────────────────────── 1a-29 6.3 5 500 0 1a-31 25 5 400 0 1a-32 25 550 000 1b-1 254 10 000 1b-2 254 000 001 b-3 225 550 000 lb-1 525 300 000 lb-5 225 000 000 1b-6 25 55 00 00 1b-8 25 55 500 0 1b-9 25 55 500 0 1b-11 25 25 34 00 00 1b-12 6.3 30 00 00 1b-1425 22 300 ───────────────────────────

Continued on the front page (51) Int.Cl. ⁶ Identification code FI C07D 403/06 209 C07D 403/06 209 405/04 257 405/04 257 409/04 257 409/04 257 417/06 257 417/06 257 ( 72) Inventor Tsutomu Naomaki 1470, Shirooka, Shirooka-cho, Minami-Saitama-gun, Saitama Prefecture (72) Inventor Kunimitsu Nakahira 1470, Shirooka, Shirooka-cho, Minami-Saitama-gun, Saitama Nissan Chemical Industry Co., Ltd. Inside

Claims (3)

[Claims] 1. Formula (1a) or (1b):[Wherein, R¹Is a hydrogen atom, C_1-8Alkyl group, C_3-7Shiku
Loalkyl group, C_3-7Substituted by a cycloalkyl group
C_1-6Alkyl group, C_3-7Cycloalkenyl group, C
_3-7C substituted by a cycloalkenyl group_1-6Archi
Group, C_2-8Alkenyl group, C_2-8Alkynyl group, C_1-6
C substituted by an alkoxy group_1-6Alkyl group, C
_2-6C substituted by an alkenyloxy group_1-6Archi
Group, C_2-6C substituted by an alkynyloxy group
_1-6Alkyl group, C_1-6Substituted by a haloalkoxy group
C_1-6Alkyl group, C_2-6Haloalkenyloxy group
Therefore, C replaced_1-6Alkyl group, C_2-6Halo alkini
C substituted by a ruoxy group _1-6Alkyl group, C_1-6
C substituted by an alkylthio group_1-6Alkyl group,
C_{1 -6}C substituted by an alkylsulfinyl group_1-6
Alkyl group, C_1-6Substituted by alkylsulfonyl group
Done C_1-6Alkyl group, C_1-8Haloalkyl group, C_{2- 8}
Haloalkenyl group, C_2-8Haloalkynyl group, cyano group
Replaced by C_{1- 6}Alkyl and cyano groups
Replaced by_2-6Alkenyl group or cyano group
Transformed C_2-6Alkynyl group, substituted by nitro group
C_1-6C substituted by an alkyl group or a nitro group
_2-6C substituted by an alkenyl group or a nitro group_2-6A
Rukinyl group, C_2-6Replaced by an alkoxycarbonyl group
Transformed C_1-6Alkyl group, C_2-6Alkoxycarbonyl
Substituted by a group_2-6Alkenyl group, C_2-6Arco
C substituted by a xycarbonyl group_2-6Alkynyl
Group, C_{2- 6}C substituted by an alkylcarbonyl group
_1-6Alkyl group, C_2-6By haloalkylcarbonyl group
Replaced by_1-6Alkyl group, C_3-6Alkenylcarbo
C substituted by a nyl group_1-6Alkyl group, C_3-6Al
C substituted by a quinylcarbonyl group_1-6Alkyl
Group, phenyl group (provided that the phenyl group is C_1-4Alkyl
Group, C_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4
Alkoxycarbonyl, cyano, nitro and halo
Substituted by one or more substituents selected from
It may be. C) replaced by_1-6Alkyl
Group, C_2-6Alkoxycarbonyl group, benzyloxyca
Rubonyl group, phenoxycarbonyl group (however,
The benzene ring of the cyclocarbonyl group is C_1-4Alkyl group, C_1-4
Haloalkyl group, C_1-4Alkoxy group, C_2-6Alkoxy
Carbonyl, cyano, nitro and halogen atoms
Even if substituted by one or more substituents selected from
Good. ), C_2-8Alkylcarbonyl group, C_4-8Cycloa
Alkylcarbonyl group, C_3-7By a cycloalkyl group
Replaced C_2-6Alkylcarbonyl group, C_3-8Alkene
Carbonyl group, C_3-8Alkynylcarbonyl group,
Nilcarbonyl group (provided that the phenylcarbonyl group
Zen ring is C_1-4Alkyl group, C_1-4Haloalkyl group, C
_1-4Alkoxy group, C_2-4Alkoxycarbonyl group, shea
At least one selected from a nitro group, a nitro group and a halogen atom
May be substituted. ), Phenyl
Substituted by a group_2-8Alkenyl group (however,
Nyl group is C_1-4Alkyl group, C_1-4Haloalkyl group, C
_1-4Alkoxy group, C_2-4Alkoxycarbonyl group, shea
At least one selected from a nitro group, a nitro group and a halogen atom
May be substituted. ), C_1-8A
Lucoxy group, C_3-7Cycloalkoxy group, C_3-7Cycloa
C substituted by an alkyl group_1-6Alkoxy group, C_2-8
Alkenyloxy group, C_2-8Alkynyloxy group, C_1-6
C substituted by an alkoxy group_1-6An alkoxy group,
C substituted by a phenyl group_1-6Alkoxy group (however
And the phenyl group is C_1-4Alkyl group, C_1-4Haloalkyl
Group, C_1-4Alkoxy group, C_2-4Alkoxycarbonyl
Group, cyano group, nitro group and halogen atom
May be substituted by one or more substituents. ),
Phenoxy group (provided that the benzene ring of the phenoxy group is C
_1-4Alkyl group, C_1-4Haloalkyl group, C _1-4Alkoki
Si group, C_2-4Alkoxycarbonyl group, cyano group, nitro
B or one or more substituents selected from halogen atoms
Therefore, it may be substituted. ), C _1-8Alkylthio
Group, C_3-7Cycloalkylthio group, C_3-7Cycloalkyl
Substituted by a group_1-6Alkylthio group, C_2-8Al
Kenylthio group, C_2-8Alkynylthio group, C_1-6Alkoki
C substituted by a group_1-6Alkylthio group, phenyl
C substituted by a_1-6Alkylthio group (however,
The phenyl group is C_1-4Alkyl group, C_1-4Haloalkyl group,
C_1-4Alkoxy group, C_2-4Alkoxycarbonyl group,
At least one selected from an ano group, a nitro group and a halogen atom
It may be substituted by the above substituent. ), Pheni
Ruthio group (provided that the benzene ring of the phenylthio group is C_1-4
Alkyl group, C_1-4Haloalkyl group, C_1-4Alkoxy
Group, C_2-4Alkoxycarbonyl group, cyano group, nitro
Group and one or more substituents selected from halogen atoms
May be substituted. ), C_1-8Alkylsulf
Inyl group, C_3-7Cycloalkylsulfinyl group, C_3-7
C substituted by a cycloalkyl group_1-6Alkyls
Rufinyl group, C_2-8Alkenylsulfinyl group, C_2-8
Alkynylsulfinyl group, C_1-6By an alkoxy group
Replaced by_1-6Alkylsulfinyl group, phenyl
Substituted by a group_1-6Alkylsulfinyl group
(However, the phenyl group is C_1-4Alkyl group, C_1-4Haloal
Kill group, C_1-4Alkoxy group, C_2-4Alkoxycarboni
, Cyano, nitro and halogen atoms
May be substituted by one or more substituents
No. ), Phenylsulfinyl group (provided that phenylsulfinyl
The benzene ring of the finyl group is C_1-4Alkyl group, C_1-4Halo
Alkyl group, C_1-4Alkoxy group, C_2-4Alkoxycal
From bonyl, cyano, nitro and halogen atoms
May be substituted by one or more selected substituents
No. ), C_1-8Alkylsulfonyl group, C_3-7Cycloal
Killsulfonyl group, C_3-7Replaced by a cycloalkyl group
Transformed C_1-6Alkylsulfonyl group, C_2-8Alkenyl
Sulfonyl group, C_2-8Alkynylsulfonyl group, C_1-6A
C substituted by a alkoxy group_1-6Alkylsulfoni
Substituted with a phenyl or phenyl group_1-6Alkyls
A rufonyl group (provided that the phenyl group is C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl, cyano, nitro and halogen
Substituted by one or more substituents selected from atoms
You may. ), Phenylsulfonyl group (provided that phenyl
The benzene ring of the sulfonyl group is C_1-4Alkyl group, C_1-4C
Loalkyl group, C_1-4Alkoxy group, C_{Two -Four}Alkoxyka
Rubonyl group, cyano group, nitro group and halogen atom
May be substituted with one or more substituents selected from
No. ), R^FourR^FiveC replaced by N_1-6Alkyl
Group, R^FourR^FiveN, R^FourR^FiveNCO, R^FourR^FiveNSO_Two, Nahchi
Group (however, C_1-4Alkyl group, C_1-4Haloalkyl group,
C_1-4Alkoxy group, C_2-4Alkoxycarbonyl group,
At least one selected from an ano group, a nitro group and a halogen atom
It may be substituted by the above substituent. ), 5-6
Membered heteroaryl group (however, C_1-4Alkyl group, C_1-4C
Loalkyl group, C_1-4Alkoxy group, C_2-4Alkoxyka
Rubonyl group, cyano group, nitro group and halogen atom
May be substituted with one or more substituents selected from
No. ), A 5- to 6-membered heteroarylmethyl group (provided that
The 6-membered heteroaryl group is C_1-4Alkyl group, C_1-4Haloa
Alkyl group, C_1-4Alkoxy group, C_2-4Alkoxycarbo
Nyl, cyano, nitro and halogen atoms
May be substituted by one or more substituents
No. ), A 5- to 6-membered heteroaryloxy group (provided that
The 6-membered heteroaryl group is C_1-4Alkyl group, C_1-4Haloa
Alkyl group, C_1-4Alkoxy group, C_2-4Alkoxycarbo
Nyl, cyano, nitro and halogen atoms
May be substituted by one or more substituents
No. ), A 5- to 6-membered heteroarylthio group (provided that 5 to 6
Membered heteroaryl group is C_1-4Alkyl group, C_1-4Haloal
Kill group, C_1-4Alkoxy group, C_2-4Alkoxycarboni
, Cyano, nitro and halogen atoms
May be substituted by one or more substituents
No. ), Phenyl group (however, C_1-4Alkyl group, C_1-4C
Loalkyl group, C_1-4Alkoxy group, C_2-4Alkoxyka
A rubonyl, cyano, nitro or halogen atom
May be substituted with one or more substituents selected from
No. ) Substituted phenyl group, oxirane ring
(However, C_1-4May be substituted by an alkyl group
No. ) Or a phenyl group (provided that C_1-4Alkyl group, C
_1-4Haloalkyl group, C_1-4Alkoxy group, C_2-4Arco
Xycarbonyl group, cyano group, nitro group, halogen source
Child, C_1-4Haloalkoxy and phenylsulfonyl
Substituted by one or more substituents selected from
Or cross-linked by a methylenedioxy group
May be. ) Represents a 5- or 6-membered heteroaryl
Ofen-2-yl group, thiophen-3-yl group, fura
2-yl group, furan-3-yl group, pyrrole-1-
Yl group, pyrrol-2-yl group, pyrrol-3-yl
Group, oxazol-2-yl group, oxazol-4-i
Group, oxazol-5-yl group, thiazol-2-i
Group, thiazol-4-yl group, thiazol-5-yl
Group, imidazol-1-yl group, imidazol-2-i
Group, imidazol-4-yl group, imidazole-5
Yl group, isoxazol-3-yl group, isoxazo
4-yl group, isoxazol-5-yl group, a
Sothiazol-3-yl group, isothiazol-4-yl
Group, isothiazol-5-yl group, pyrazol-1-i
Group, pyrazol-3-yl group, pyrazol-4-yl
Group, pyrazol-5-yl group, 1,3,4-oxadia
Zol-2-yl group, 1,3,4-thiadiazole-2
-Yl group, 1,3,4-triazol-1-yl group,
1,3,4-triazol-2-yl group, 1,2,4-
Oxadiazol-3-yl group, 1,2,4-oxadi
Azole-5-yl group, 1,2,4-thiadiazole-
3-yl group, 1,2,4-thiadiazol-5-yl
A 1,2,4-triazol-1-yl group, 1,2,2
4-triazol-3-yl group, 1,2,4-triazo
5-yl group, 1,2,3-oxadiazole-4
-Yl group, 1,2,3-oxadiazol-5-yl
Group, 1,2,3-thiadiazol-3-yl group, 1,
2,3-thiadiazol-5-yl group, 1,2,3-to
Liazol-1-yl group, 1,2,3-triazole-
4-yl group, 1,2,3-triazol-5-yl group,
1,2,3,4-tetrazol-1-yl group, 1,2,2
3,4-tetrazol-5-yl group, 1,2,3,5-
Tetrazol-1-yl group, 1,2,3,5-tetrazo
-4-yl group, pyridine-2-yl group, pyridine-
3-yl group, pyridin-4-yl group, pyrimidine-2-
Yl group, pyrimidin-5-yl group, pyrimidine-4-i
Group, pyrazin-2-yl group, pyridazin-3-yl
Group, pyridazin-4-yl group, 1,3,5-triazine
-2-yl group, 1,2,4-triazin-3-yl group,
1,2,4-triazin-5-yl group or 1,2,4
-Triazin-6-yl group, quinolin-2-yl group,
Nolin-3-yl group, isoquinolin-1-yl group, iso
A quinolin-3-yl group, a quinoxalin-2-yl group or
Represents a benzothiazol-2-yl group;^TwoAnd R^Three
Is independently a hydrogen atom, C_1-6Alkyl group, C_3-6
Cycloalkyl group, C_2-4Alkenyl group, C_2-4Alkini
Group, C_1-4Haloalkyl group, C_3-6With a cycloalkyl group
Replaced C_1-2Alkyl group, C_1-4Alkoxy group (however
Then R ^TwoAnd R^ThreeCannot simultaneously represent an alkoxy group
No. ), C_1-4Alkoxy C_1-4Alkyl group, C_1-4Al
Kircio C_1-4Alkyl group, phenyl group (provided that phenyl
The radical is C_1-4Alkyl group, C_1-4Haloalkyl group, C_1-4
Alkoxy, cyano, nitro and halogen atoms
Even if substituted by one or more substituents selected from
Good. ) Or a benzyl group, provided that R^TwoAnd R^Three
Constitutes a 3- to 9-membered ring with the nitrogen atom
Oxygen atom, sulfur atom, C_1-4Alkyl group
A nitrogen atom, a carbonyl group,
It may contain a honyl group or an unsaturated bond, and the ring is
_1-4The ring may be substituted by an alkyl group,
_1-4The ring may be bridged by alkylene,
May be condensed by a benzene ring;^FourAnd R^Five
Is independently a hydrogen atom, C_1-6Alkyl group, C_3-6
Cycloalkyl group, C_2-4Alkenyl group, C_2-4Alkini
Group, C_1-4Haloalkyl group, C_3-6With a cycloalkyl group
Replaced C_1-2Alkyl group, C_1-4Alkoxy group (however
Then R ^FourAnd R^FiveCannot simultaneously represent an alkoxy group
No. ), C_1-4Alkoxy C_1-4Alkyl group, C_1-4Al
Kircio C_1-4Alkyl group, phenyl group (provided that phenyl
The radical is C_1-4Alkyl group, C_1-4Haloalkyl group, C_1-4
Alkoxy, cyano, nitro and halogen atoms
Even if substituted by one or more substituents selected from
Good. ) Or a benzyl group, provided that R^FourAnd R^Five
Constitutes a 3- to 9-membered ring with the nitrogen atom
Oxygen atom, sulfur atom, C_1-4Alkyl group
A nitrogen atom, a carbonyl group,
It may contain a honyl group or an unsaturated bond, and the ring is
_1-4The ring may be substituted by an alkyl group,
_1-4The ring may be bridged by alkylene,
W may be fused with an oxygen ring
Alternatively, it represents a sulfur atom. Carbamoylte represented by
A pesticide containing tolazole as an active ingredient. 2. A herbicide comprising the compound according to claim 1 as an active ingredient. Wherein R ¹ is a phenyl group (wherein, C _1-4 alkyl, C _1-4 haloalkyl group, C _1-4 alkoxy, C _2-4
It may be substituted by one or more substituents selected from an alkoxycarbonyl group, a cyano group, a nitro group and a halogen atom. 2. The carbamoyltetrazole according to claim 1, except for the following.