GB2503524A - Tetrazole compounds useful as intermediates for the preparation of herbicides - Google Patents

Tetrazole compounds useful as intermediates for the preparation of herbicides Download PDF

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GB2503524A
GB2503524A GB201215178A GB201215178A GB2503524A GB 2503524 A GB2503524 A GB 2503524A GB 201215178 A GB201215178 A GB 201215178A GB 201215178 A GB201215178 A GB 201215178A GB 2503524 A GB2503524 A GB 2503524A
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Prior art keywords
pyrazol
tetrazole
iodo
methyl
chloro
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GB201215178D0 (en
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Sanjay Sambhajirao Palimkar
Jivan Dhanraj Pawar
B Sankar
Prosenjit Bose
Subhash Rajaram Kadam
Rama Mohan Hindupur
Venkatesh M Prabhu
Hari Narayan Pati
Vadiraj Gopinath Suphala
Avinash Sheshrao Mane
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Rallis India Ltd
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Rallis India Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Abstract

Tetrazole compounds of formula I may be useful as intermediates for the preparation of sulfonamide or sulfonyl urea growth regulators or herbicides (e.g. Azimsulfuron). R1 is H, Cl, Br or I; R2 is H or C1-7 alkyl (which may be substituted with a substituted phenyl group); R3 is optionally substituted C1-7 alkyl or C6-14 aryl; with the proviso that when R1 is H R2 is not methyl. The compound may be 5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2H-tetrazole. Compound I may be made by reaction of a 1H-pyrazole-4-carbonitrile of formula II with sodium azide.

Description

SUBSTITUTED TETRAZOLE COMPOUNDS ANI) PROCESS THEREOF
TECHNICAL FIELD
The present disclosure relates to substituted tetrazole compounds, its derivatives, salts, stereo-isomers or regio-isorners thereol which are useful as intermediates in the preparation of herbicidal sulfonamide or sulfonyl urea growth regulators or herbicides.
The present disclosure also relates to methods for the preparation of such intermediates.
BACKGROUND
Sulfonamide or sulfonyl urea growth regulators or herbicides are a more recent class of chemical compounds that function by inhibiting the action of a plant enzyme, stopping plant growth, and eventually killing the plant. These are well known as being highly beneficial for controlling undesirable vegetation in agronomically desirable crops.
The sulfonamide herbicides are reported to he prepared by various ways in the art, EP02045 13 B 1, which is incorporated in its entirety by reference, describes the method for preparation of such sulfonylureas and sulfonylthioureas herbicide from sulfonyl isocyanate or isocyanate intermediates with an appropriate heterocyclic arnines. The patent document further discloses the preparation of the sulfonyl isocyanate intermediates by reacting appropriate sulfonamide with phosgene in presence of n-butyl isocyanate and 1.4-diazahicyclo[2.2.2]octane, Further. sulfonyl thioisocyanates are reported to he prepared by reacting corresponding sulfonamides with carbon disulphide mid potassium hydroxide to form dipotassium salt which on treatment with phosgene provides the isothiocyanate intermediates.
The patent US4650892 discloses a process of preparation of sulfonamide herbicides using aromatic sulfonyl chlorides and sulfonamides.
One type of sulfonamide herbicides is Azimsuifliron or N-[(4.6-dimethoxy-2- pyrimidinyI)amino]carhony-l -methyl-4-(2-rnethyl-2T-l-tetrazol-5-yI)-I H-pyrazole-5-sulfonamide, which is well known and has been found to be particularly useful as post emergent hcrbicidcs when used against sensitive wccds. Azinisulftiron affects sensitive weeds through inhibition of the enzyme acetolactate synthase (ALS).
In view of the importance of the emerging sulfonamide or sulfonyl urea growth regulators or herbicides, there remains a need for developing new intermediates and viable processes for their synthesis that can be successfully used in the preparation of these herbi cidal compounds
SUMMARY
The present disclosure relates to substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof, of formula I R,
I N\ R1 \/
Formula I wherein: R1 is selected from H, Cl, Br or 1; R, is selected froi-n hydrogen or a straight chain or a branched C1 alkyl; wherein said alkyl is optionally substituted with a phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Cl, Br, F. I, NO2, CN. C15 alkyl, phenyl, or a C1-C4 alkoxy; and R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy; with the proviso that when K1 is N; R2 is not methyl.
The present disclosure further provides a process for preparing substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomcrs thereof of formula I. These and other features, aspects, and advantages of the present disclosure will become better undcrstood with reference to the following description. This statement is provided to introduce a selection of concepts in a simplified form. This statement is not intended to identify key features or essential features of the. subject matter, nor is it intended to be used to limit the scope of the subject matter.
DETAILE1) DESCRIPTION
Definitions In the structural formula given herein and throughout the present disclosure, the following terms have the indicated meaning, unless specifically stated otherwise.
The term "optionally substituted" as used herein means that the group in question is either unsubstituted or substituted with one or more of the substituents specified. When the group in question is substituted with more than one substituent, the substituent may be same or different, "Halo" or "Halogen", alone or in combination with any other term means halogens such as chloro (Cl), bromo (Br), fluoro (F) and iodo (I).
The term C17 alkyl" refers to a monoradical branched or unhranched saturated hydrocarbon chain having 1, 2, 3, 4. 5, 6 or 7 carbon atoms. This term is exemplified by groups such as methyl, ethyl, n-propyl, iso-propyl, n-butyl, iso-butyl. t-butyl. n-hexyl, n-heptyl, and the like which optionally carries one or more substituenis, preferably one to two, each independently selected from Cl, Br, F, I, NO2, CN, C1.5 alky!, phenyl or a C1-C4 alicoxy.
The term "C6-C14 aryl" refers to an aromatic carbocyclic group of 6 to 14 carbon atoms having a single ring (e.g. phenyl) or multiple rings (e.g. biphenyl), or multiple condensed (ftsed) rings (e.g. na.phthyl or anthranyl). Preferred aryls include phenyl. naphthyl and the like which optionally carries one or more suhstitLLens, preferably one to two, each independently selected from Ci, Br, F, T, C15 alkyl, phenyl or a C -C4 alkoxy.
is The compounds described herein may contain one or more chiral centers and/or double bonds and therefore, may exist as stereo-isomers, such as geometric isomers, enantiomers or diastereomers. Accordingly, the chemical structures depicted herein encompass all possible enantiomers and stereo-isomers of the illustrated or identified compounds including the stereoisomerically pure form (e.g.. geometrically pure, enantiomerically pure or diastereomerically pure) and cnantiomcric and stercoisomeric mixtures, Enantionierie and stercoisomeric mixtures can be resolved into their component enantiomers or stereo-isomers using separation techniques or chiral synthesis techniques well known to the person skilled in the art. The compounds may also exist in several tautomeric forms including the enol form, the keto form and mixtures thereof Accordingly, the chemical structures depicted herein encompass all possible tautomerie forms of the illustrated or identified compounds.
The present disclosure will be described more fully hereinafter. Indeed, the invention can be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. As used in the specification, and in the appended claims, the singular fonts "a", "an", "the", include plural referents unless the context clearly dictates otherwise.
The present disclosure provides substituted tetrazole compounds, its derivatives, salts, stereo-isomers or regio-isomers thereof, which arc useful as intermediates in the preparation of herbicidal sulfonamide. Accordingly, the present disclosure provides substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof, of formula I
I
N N'
Formula I S wherein: R1 is selected from H, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C1 rj aiRy]; whcrcin said alkyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Cl, Br, F, I, NO2, CN, C15 alkyl, phenyl, or a C1-C4 alkoxy; and R3 is selected from a straight or a branched chain C1.7 alkyl; or a C6-C14 aryl group; whcrcin said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C 1-C1 alkoxy; with the proviso that when R1 is H; R2 is not methyl.
An embodiment of the present disclosure provides substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof, of formula I wherein: R1 is sclectcd from H, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C13 alkyl; wherein said alkyl is optionally substituted with a phcnyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Br, NO2, CN, Ci.5 alkyl, or a C 1-C4 alkoxy; and R3 is selected from a straight or a branched chain C14 alkyl; or a C6 aryl group, whcrcin said straight or branched chain alkyl is optionally substituted with a phenyl group; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, C12 ailcyl, or a C1-C4 alkoxy; with the proviso that when R1 is H; R2 is not methyl.
Another embodiment of tile present disclosure provides substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof, of formula I wherein: R1 is selected from Cl, Br or I; R is selected from hydrogen or a straight chain or a branched C17 alkyl; wherein said alkyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substitueni independently selected from Cl, Br, F, I, NO2. CN, C5 alkyl, phenyl, or a CrC4 alkoxy; and R3 is selected from a straight or a branched chain C17 alkyl or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl or a C1-C4 alkoxy.
Yet another embodiment of the present disclosure provides substituted teuazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof, of formula I wherein: is selected from Cl, Br or I; R2 is hydrogen or methyl; and R3 is selected from a shaight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F. I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Ci, Br, F, I, C15 alkyl, or a C1-C4 alkoxy.
Still another embodiment of the present disclosure provides a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isorners thereof, of formula I, selected from 5-( I -methyl-I H-pyrazol-4-yl)-2H-tetrazole; 5-( I-ethyl-i II-pyrazol-4-yl)-21-l-tctrazole; 541 -(2-methyipropyl)-1 H-pyrazol-4-yIJ-2H-tetrazole; 5-(l -benzyl-1II-pyrazol-4-yl)-2H-tetrazole; 5-( 1 -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; 5-fl -(2-chiorophenyl)-I l-1-pyrazol-4-yl]-2H-tetrazole; 5-[ 1 -(3 -chlorophenyl)-1 H-pyrazol-4-yll-2H-tetrazole; 5-[l -(4-chlorophenyl)-l H-pyrazol-4-yIj-2H-tetrazole; 5-[1 -(2,3-dichiorophenyl)-1I-I-pyrazol-4-yl]-2H-tetrazole; 5-LI -(2,4-dichiorophenyl)-1H-pyrazol-4-ylJ-2H-tetrazole: 5-[1 -(2,5-dichlorophenyl)-1 H-pyrazol -4-yl]-2 H-tetrazolc; 5-[1 -(2,6-dichiorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole: S 5-li -(3,4-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-11 -@ ,5-diclilorophenyl)-11 I-pyrazol-4-yI]-21-1-tetrazole; 5-11 -(2-broniophenyl)-I U-pyrazol-4-ylj-2}-1-tetrazole; 5-11 -(3-bromopheny1)-1H-pyruzo1-4-y1-2II-tetrazo1e; 5-11 -(4-bromophenyl)-I H-pyrazol-4-y]j-2H-tetrazole; 5-11 -(4-Iluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(2-fluorophenyl)-11 I-pyrazol-4-yl]-2H-tetrazolc; 5-[1 -( ,3-dirnethylphenyl)-1 I-1-pyrazol-4-yI]-21i-tetrazole; 5-[1 -(2,4-dimcthylphcnyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 5-11 -(2,5-dimethyiphenyl)-I 1-T-pyrazol -4-yI]-2T-T-tetrazole; 5-11 -(2,6-dimethylphenyl)-1 II-pyrazol-4-yl]-2i-1-tetrazole; 5-11 -(3,4-dirnethylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 5-11 -(3,5-dimethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(-e1Fy1pheny1)-1I-l-pyrazo1-4-y1]-2II-tetrazo1e; 5-[1 -(4-ethylphenyl)-1 H-pyrazo]-4-ylj-2H-tetrazole; 5-11 -(4-methoxyphenyl)-1H-pyrazol-4-yl]-211-tctrazole; 5-[ I -(2-methyiphenyl)-1 H-pyrazol-4-yl] -21 1-tetrazole; 5-11 -(4-mcthylphcnyl)-1 H-pyrazol -4-yl] -2H-tetrazole; 5-(5 -chloro-1-methyl-i H-pyrazol-4-yl)-2H-tetrazole; 5-(5 -chioro-1-ethyl-1 H-pyrazoi-4-yl)-21 1-tetrazole; 5-[5-chloro-I -(2-methylpropyl)-1 i-1-pyrazol-4-yl]-21-1-tetrazole; 5-( 1 -benzyl-5-chloro-1 H-pyrazol-4-yl)-2H-tetrazo Ic; 5-(5 -chloro-1 -phenyl -I 1-1-pyrazol -4-yI)-21-1-tctrazolc; 5-[5-cliloro-1 -(2-chlorophenyl)-iH-pyrazol-4-yll-211-tetrazole; 5-[5-chloro-I -(3-chlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[5 -chioro-1 -(4-chiorophenyl)-1 I-I-pyrazol-4-yl] -2H-tetrazole; 5-[5-chloro-1 -(2,3-dichiorophenyl)-I H-pyrazol-4-yl]-21-I-tetrazole; 5-[5 -chioro-1 -(2,4-dichiorophenyl)-ii I-pyrazol-4-yf] -21-1-tetrazole; 5-15-chioro-I -(2,5-dichiorophenyl)-iH-pyrazol-4-yl]-2H-tetrazole; 5-45 -chioro-1 -(2,6-dichlorophcnyl)-ii I-pyrazol-4-yfl -2H-tetrazole; 5-L5-chloro-1-(3,4-diehlorophenyl)-1FI-pyrazol-4-yl]-2H-tetrazole; 5-L5-ch1oro-1-(3,5-diehloropheny-1FI-pyrazol-4-yl]-21-I-tetrazole; 5-[1-(2-bromophenyl)-5-chloro-1 H-pyrazo]-4-yl]-2H-tetrazolc; 5-[l-(3-brornophenv1)-5-eh1oro-1H-pyrazo1-4-y1-2IT-tetrazole; S 5-[l -(4-hromophenyl)-5-ehloro-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[5-chloro-1-(4-fluorophenyl)-1II-pyrazol-4-y!]-2H-tetrazole; 5-[5-ehloro-l -(2-fluorophenyl)-1H-pyrazol--4-yl]-2H-teirazole; 5-[5-chloro-l -(2,3-diniethylphenyl)-III-pyrazol-4-yl]-2H-tetrazoie; 5-15-chloro-1 -(2,4-dimethyiphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 5-[5-ehloro-1-(2,5-dimethylphenyl)-1H-pyrazol-4-vl]-2H-tetrazole; 5-L5-ehloro-1-(2,6-dimethylphenyl)-III-pyrazol-4-yl]-2H-tctrazole; 5-[5-chloro-1 -(3,4-dirnethylphenyl)-I H-pyrazol-4-ylj-21-I-tetrazole; 5-[5-chloro-1-(3,5-dimcthylphcnyl)-IH-pyrazol-4-vl]-2H-tetrazole; 5-[5-chloro-1 -(2-ethvlphenyl)-1 II-pyrazol-4-yl]-2H-tetrazole; 5-[5 -chioro-1 -(4-ethyiphenyl)-1 H-pyrazol-4-yll -21 1-tetrazole; 5-[5-chloro-l -(4-mcthoxyphenyl)-IR-pyrazol-4-yl]-2H-tetrazole; 5-[5-chioro-1 -(2-methylphenyl)-I H-pyrazol-4-yfl-2H-tetrazole; 5-[5 -chloro-1 -(4-methyiphenyl)-1 11-pyrazol-4-yl]-21 1-tetrazole; 5-(5-bromo-1 -methyl-I 1-i-pyrazo[-4-yi)-2H-tetrazole; 5-(5-bromo-1-ethyl-i H-pyrazol-4-yl)-2H-tetrazolc; 5-[5-bromo-I -(2-rnethylpropyl)-IH-pyrazol-4-yl]-2H-tetrazole; 5-( 1 -benzyl-5-brorno-1 H-pyrazol-4-yl)-2H-tctrazolc; 5-(5-bromo-1 -phenyl-11 I-pyrazol-4-yl)-2H-tetrazole; 5-[5-brorno-I -(2-chlorophenyl)-IH-pyrazol-4-ylj-2U-tetrazole; 5-[5-bromo-I -(3-chlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[5 -bromo-I -(4-chiorophenyl)-1 H-pyrazol-4-yl] -2H-tetrazole; 5-[5 -bromo-1 -(2.3-dichlorophenyl)-11 I-pyrazol-4-yl] -21-1-tetrazole; 5-[5 -brorno-1 -(2,4-dichlorophenyl)-1H-pyrazol-4-yl] -2H-tetrazole; 5-[5-bromo-1 -(2,5-dichlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 5-[5-brorno-1 -(2.6-dichlorophenyl)-1H-pyrazoi-4-yl]-2H-tetrazole; 5-[5-bromo-1 -(3,4-dichlorophenyl)-1 H-pyra2ol-4-yI]-2H-tetrazolc; 5-[5 -bromo-1 -(3,5-dichlorophenyl)-1 H-pyrazol-4-yl] -21-1-tetrazole; 5-[5-hromo-I -(2-bromophenyl)-I H-pyrazol-4-ylj-2H-tetrazole; 5-[5 -bromo-1 -(3 -bromophenyl)-1 H-pyrazol-4-yl]-2H-tetrazolc; 5-[5 -brorno-1 -(4-brornophenyl)-1 H-pyTazol-4-yl] -2H-tetrazole; 5-[5-bromo-l -(4-fluorophenyl)-1 1-T-pyrazol-4-yl]-2H-tetrazole; 5-[5-brorno-l-(2-lluorophenyl)-1H-pyrazol-4-yl]-2H-telrazole; 5-[5-hromo-1 -(2,3-dimethyiphenyl)-H-pyrazol-4-yfl-2H-tetrazolc; 5-[5 -bromo-1 -(2,4-dirnethyiphenyl)-1 H-pyrazol-4-yl] -2H-tetrazole; 5-[5-brorno-1 (2,5-dimethy1phenyl)-1H-pyrazol-4-yl]-2H4etrazole; 5-[5-bromo-1 -(2,6-dirnethyiphenyl)-liI-pyrazol-4-yll-211-tetrazole; 5-[5-broino-1-(3,4-dimetliylphenvl)-1I-1-pyrazol-4-yfl-2H-tetrazole; 5-[5-bromo-1-(3,5-dimethylphenyl)-IR-pyrazol-4-yll-2H-tctrazole; 5-[5-bromo-1-(2-ethylphenyl)-1iI-pyrazol-4-yIj-211-tetrazole; 5-[5-bronio-1 -(4-ethypheny1)-W-pyrazol-4-yiJ-2H-tetrazole; 5-[5 -bromo-I -(4-methoxyphenyl)-1 H-pyrazol-4-yl] -2H-tetrazole; 5-[5 -bromo-1 -(2-methyiphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[5 -brorno-1 -(4-methyiphenyl)-IH-pyrazol-4-yl I-2H-tetrazole; 5-(5-iodo-I-rnetl1yl-11-1-pyrazol-4-yl)-2H-lelraole; 5-0 -cthyl-5-iodo-1 H-pyrazo]-4-yJ)-2H-tetrazole; 5-[5 -iodo-I -(2-methylpropyl)-1 I-1-pyrazo!-4-yl]-21-1-tetrazole; -0 benzy15-iodo-1 l-T-pyrazol-4-yl)-2H-tetrazole; 5-[1 -(2-chlorophenyl)-5-iodo-1II-pyrazol-4-yll-2F1-tetrazole; 5-[ 1 -(3-chlorophenyl)-5-iodo-1 H-pyrazol-4-ylj -2F1-tetrazole; 5-[1 -(4-chlorophenyl)-5-iodo-1 1-I-pyrazol-4-yl]-2H-tetrazole; 5-[l -(2,3-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(2,4-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[ 1 -(2.5-dichlorophenyl)-5-iodo-1 M-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(2,6-diehlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2H-tetrazole; 5-[l -(3,4-diehlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; 5-Il -(3,5-dichlorophenyl)-5-iodo-1II-pyrazol-4-ylj-21T-tetrazole; 5-[l-(2-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-ietrazole; 5-41 -(3-hromophenyl)-5-iodo-I l-I-pyrazol-4-yl]-2H-tetrazole; 5-[1-(4-bromophenyl)-5-iodo-1FI-pyrazol-4-yl]-2H-letrazole; I -(4-fiuorophenyl)-5-iodo-I H-pyrazol-4-yI]-2H-tetrazole; 5-[l-(2-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 5-[l -( ,3-dirncthylphenyl)-5-iodo-1 H-pyrazo]-4-yl]-2H-tetrazole; 5-[l -(2,4-dimethylphenyl)-5-iodo-IH-pyrazol-4-ylJ-2H-tetrazole; 541 -(2,5-din-iethylphenyl)-5-iodo-lH-pyrazol-4-ylJ-2H-tetrazole; 5-[1 -(2,6-dimethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[1-(3,4-dimethylphenyl)-5-iodo-lI-I-pvrazo1-4-y1-2II-tetrazole: 5-[1-(3,5-dimethylphcnyl)-5-iodo-IH-pyrazol-4-ylJ-2H-tetrazolc; 5-[1 -(2-ethylphenyl)-5-iodo-1I-I-pyrazol-4-yll-211-tetrazole; 5-[1 -(4-ethyphcny1)-5-iodo-1H-pvrazol-4-yl]-2H-teftazole; 5-[5-iodo-1 -(4-methoxyphcnyl)-1Ii-pyrazol-4-yl]-21-1-tetrazo[e; 5-[5-iodo-1-(2-mcthylphenvl)-1 H-pyrazol-4-yl]-21-i-tetrazole; or 5-[5-iodo-1 -(4-methyiphenyl)-1 H-pyrazol-4-yl] -2H-tetrazole.
Further an embodiment of the present disclosure provides a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or reglo-isomers thereoL of formula I which are listed below. In accordance with the prcsent invention, the regio-isomers of compounds of formula I are also within the scope of the present disclosure, wherein the alkyl group of R2 is in 1 or 2 position of the tetrazole ring. Certain compounds of the present disclosure is selected from 5-(1 -ethyl-lH-pyrazol-4-yl)-2-methyl-211-tetrazole; -(1-ethyl-i H-pyrazol-4-yl)-1 -methyl-2H-tetrazole; 2-methyl-S -[1 -(2-mcthylpropyl)-1 H-pyrazol-4-yI]-2H-tetrazole; I -methyl-5-[l -(2-methylpropyl)-1H-pyrazol-4-yl]-211-tctrazolc; 5-(1 -benzyl-1 I-l-pyrazoL-4-y-2-methy-2H-tetrazo1e; -(1 -benzyl-1 I-I-pyrazol-4-yl)-1 -mcthyl-21-l-tetrazole; 2-methyl-5-(l-phenyl-lfI-pyrazol-4-yl)-211-tetrazole; I -methyl-5 -( I -phenyl-1 i-1-pyrazol-4-yl)-21-1-tetrazole; 5-[1 -(2-ehiorophenyl)-1 Fi-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[1 -(2-chlorophenyl)-1 II-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[l -(3-chlorophenyl)-1 H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-El -(3-ehlorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-2H-letrazole; 5-Il -(4-ch lorophenyl)-1 I-J-pyrazo]-4-yl]-2-mcthyl-2H-tetrazole; 5-El -(4-chlorophenyl)-I H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; S-[l -(2.3-diehlorophenyl)-l H-pyrazol-4-yfl-2-methyl-21-I-tetrazole; 5-El -(2,3 -diclilorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-211-tetrazole; 5-[l -(2,4-dichiorophenyl)-I H-pyrazol-4-yfl-2-methyl-2H-tetrazole; 5-[ 1 -(2,4-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-211-tetrazole; 5-Il -(2,5-diehlorophenyl)-H-pyrazo]-4-ylj-2-methyl-2H-tetrazole; 5-[1 42,5-dich1oropheny1)-1II-pyrazo1-4-y1]--methy1-2H-tetrazo1e; 5-[1 -(2,6-dieh1oropheny1)1Hpyrazo1-4-y1]-2-methy1-2iI-tetrazo1e; 541 -(2,6-dichlorophenyl)-1II-pyrazol-4-y!]-1 -rnethy!-2H-tctrazole; 5-[1 -(3,4-diehlorophenyl)-1 H-pyra2ol-4-yl]-2-rnethyl-2H-tetrazole; 5-[1-(3,4-dichlorophcnyl)-1II-pyrazol-4-yl]-1 -rnethy-2H-tetrazo1e; I -(3.5-dichlorophenyl)-1 IT-pyrazol-4-yl]-2-rnethyl-2H-tctrazole; 5-[1-(3,5-dichlorophenyl)-1 H-pyrazol-4-yij-1-rnethyl-2H-tetrazole; 5-[I -(2-brornopheny] )-I H-pyrazol-4-yll -2-methyl-21-l-tetrazole; 5-[1-(2-brornophenyl)-1 H-pyraz&-4-yI]-i-methyl-2H-tetrazole; 5-[ 1 -(3-bromophenyl)-1 H-pyrazol-4-yfl -2-rnethyl-2H-tetrazole; 5-[1 -(3-bromophenyl)-1H-pyrazol-4-yll-1 -methyl-2H-tetrazolc; 5-[ I -(4-brornophenyl)-1 H-pyrazol-4-yl] -2-rnethyl-2H-tetrazole; 5-[1 -(4-hromophenyl)-1 H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[1-(4-fluorophenyl)-1FI-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[ 1 -(4-iluorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-21-T-tetrazo le; 5-[1-(2-fluorophenyl)-1 H-pyrazol-4-yij-2-methyl-21i-tetrazole; 5-El -(2-f1uoropheny)-1 H-pyrazol-4-yfl--methyl-21-I-tetrazole; 5-[1-(2.3-dimethylphenyl)-1I-1-pyrazol-4-yL]-2-methvl-2H-tetrazole; 5-[1-(2.3-dimethylphenyl)-1H-pyrazol-4-yll-1 -rnethyl-2H-tetrazole; 5-[I -(2.4-dimethyiphenyl)-] I-i-pyrazol-4-vfl-2-methyl-211-tetrazole; 5-[1 -(2.4-dimethyiphenyl)-I H-pyrazol-4-yI j-i -rnethyl-2F1-tetrazole; 5-El -(2.5-dirnethylphenyl)-1H-pvrazol-4-vl]-2-rnethyl-2H-tetrazole; 5-[ 1 -(2.5-dirnethylphenyl)-l]J-pyrazol-4-yl]-1 -methyl-2H-tctraz&c; 5-[1 -(2.6-dirnethyiphenyl)-I H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[I -(2,6-dimethylphenyl)-I H-pyrazol-4-vl]-1-methyl-2H-telrazole; 5-[1-(3,4-dirnethylphenyl)-lII-pyrazol-4-yI]-2-mcthyl-2H-tetrazole; 5-[1-(3.4-dimethylphenyl)-1I-I-pyrazol-4-yIl-1 -methyl-2l-1-tetrazole; 5-[1 -(15-dimethylphenyl)-1H-pyrazol-4-vl]-2-methyl-2H-tetrazole; 5-[1-(3.5-dirnethylphenyl)-1H-pvrazol-4-yll-1-methyl-211-tetrazole; 5-[l -(2-ethy!phenyl)-1 H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[1-(2-ethylphenyl)-1 EI-pyrazol-4-yll-1 -methyl-2H-tetrazole; 5-I-(4-ethy1pheny1)-1 I-I-pyrazol-4-yl]-2-methyl-211-tetrazole; 5-[ 1 -(4-ethylphenyl)-I H-pyrazol-4-yl] -I -rnethyl-2 H-tetraz&e; 5-[1-(4-rnethoxyphenyl)-1II-pyrazol-4-yll-2-methyl-211-tetrazole; 5-[1 -(4-niethoxyphenyl)-1H-pyrazol-4-yI j-1 -methyl-2H-tetrazole; 2-methyl-S -[1 -(2-methylphenyl)-11 I-pyrazol-4-yfl -211-tetrazole; I -methyl-5-[1-(2-rnethyiphenyl)-IH-pyrazoh4M]-2H-tefrazole; 2-methyl-S -[1 -(4-methylphenyl)-1 II-pyrazol-4-yl] -211-tetrazole; 1 -methyl-S -[1 -(4-methylphenyl)-11-I-pyrazol-4-yl] -2H-tetrao1e; 5-(5-chloro-1 -methyl-I H-pyrazol-4-yl)-2-methyl-21-{-tetrazole; 5-(5-ehloro-l-rnethyl-1II-pyrazol-4-yl)-1-rnethyl-211-tetrazole; 5-(5-chloro-1-ethyl-1 H-pyrazol-4-yl)-2-methyl-2H-tetrazole; 5-(S-chloro-1-ethyl-lII-pyrazol-4-yl)-1-methyl-2H-tetrazole; 5-[5-ehioro-1 -(2-methylpropyl)-1 H-pyraz&-4-yl]-2-methyl-2H-letrazole; 5-[5-ehloro-I -(2-methylpropyl)-1 H-pyrazol-4-ylj-1 -rnethyl-2H-tetrazole; 5-(I -benzyl-5-chloro-1 T-T-pyraz&-4-yl)-2-methyl-21-1-tetrazole; 5-( 1 -benzyl-5-chloro-II I-pyrazol-4-yl)-1 -methyl-21 1-tetrazole; 5-(5-ehloro-1 -phenyl-1 H-pyrazol-4-yl)-2-rnethyl-2H-tetrazole; 5-(5-ehloro-i -phenyi-1 H-pyrazol-4-yI)-1 -rnethyl-2H-tetrazole; 5-[5-chloro-1 -(2-chloroplienyl)-I H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[5-ehloro-1 -(2-chlorophenyl)-1H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-chloro-1 -(3-chlorophenyl)-11-i-pyrazol-4-yl]-2-methyl-211-tetrazole; 5-[5-chloro-1 -(3-chlorophenyl)-1H-pyrazol-4-yl]-1-methyl-21-1-tetrazole; 5-[5-chloro-I -(4-chlorophenyl)-I H-pyrazol-4-yfl-2-methyl-2F1-tctrazolc; S-[5-chloro-1-('-ch1oropheny1)-1H-pyrazo1-4-y1]-1-methyl-2I-1-tetrazo1e; 5-[5-chloro-1-(2,3-dichlorophenyl)-I-1-pyrazol-4-y] J-2-rneihyl-2H-tetrazole; 5-[5-chloro--(2,3-dichiorophenyl)-I H-pyrazol-4-yi]-1 -rnethyl-2H-tetrazole; 5-[5-chloro-1 -( ,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-chloro-l -(2,4-dichlorophenyl)-IH-pyrazol-4-yl]-1 -methyl-211-tetrazole; 5-{5-chloro-1-(2,S-dichlorophenyl) -1H-pyrazol-4-ylj-2-rnethyl-21-1-tetrazole; 5-{5-chloro-1 -(2,5-dichlorophenyl)-1H-pyrazol-4-yl]-I -methyl-2H-tetrazole; 5-[5-chloro-I -(26-dichlorophenyl)-11-I-pyrazol-4-yl]-2-methyl-2I1-tetrazole; 5-[5chloro-1-(2,64ichlorophenyl)-IH-pyrazol-4-ylj-] -rnethyl-21-f-tctrazole; 5-[5-chloro-I -(34-dich1orophenyl)-1II-pyrazol-4-yl]-2-methy1-2II-tetrazole; 5-[5-chloro-l-(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-1 -rnethyl-2H-tetrazole; 5-[5-chloro-I -(3,5-diehlorophenyl)-I H-pyrazol-4-yl]-2-methyl-21I-tctrazolc; 5-[5-chloro-1-(3,5-dichlorophenyl)-1II-pyrazol-4-yl]-1 -rnethyl-211-tetrazole; 5-[l-(2-broniophenyl)-5-chloro-I H-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[1 -(2-brornopheny1)-5-ch1oro-1I-I-pyTazo1-4-y1-1-methyI-2FJ-tetrazole; 5-[1 -(3-hromophenyl)-5-eh]oro-IH-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; [1 (3 -bromophenyl)-5-chloro-1 I-I-pyrazol-4-yll-1 -methyl-21-1-tetrazo!e; 5-[1 -(4-hromophcny])-5-chloro-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[1 -(4-brornophenyl)-5-chloro-1II-pyrazol-4-yl]-I -methyl-2H-tetrazole; 5-[5-ehloro-1 -(4-fluorophenyl)-1I1-pyrazo1-4-y1-2-rnethy1-2H-tetrazo1e; 5-[5-chloro-1 -(4-fluorophenyl)-1H-pyrazol-4-yI]-I -rnethyl-21-I-tetrazole; 5-[5-chloro-1 -(2-fluorophenyl)-1 T-1-pyrazol-4-yfl-2-methyl-211-tetrazole; 5-[5-chloro-1-(2-fluorophenyl)-lH-pyrazol-4-yI]-1 -rnethyi-2H-letrazole; 5-[5-chloro-1-(2,3-dirnethylphenyl)-1H-pyrazol-4-yl] -2-rnethyl-2H-tetrazole; 5-[5-ehloro-I -(2.3-dimethylphenyl)-IH-pyrazol-4-yl]-1-methyl-21-1-tetrazole; 5-[5-chloro-I -(2,4-dirnethylphenyl)-IH-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-15-ch1oro-1-(2,4-dimethy1pheny-1 H-pyrazol-4-ylj-1-rnethyl-2F1-tetrazole; 5-[5-chloro-1-(2,5-dirnethylphenyl) -1H-pyrazol-4-yfl-2-methyl-211-tetrazole; 5-[5-chloro-1-(2,5-dirnethylphenyl)-1H-pyrazol-4-vl] -1-methyl-21-I-tetrazole; 5-15-ch1oro-1-(2,6-dimethy1pheny-1 H-pyrazol-4-ylj-2-niethyl-2H-tetrazole; 5-[5-chloro-1-(2,6-dimethylphenyl)-1II-pyrazo!-4-yI]-1 -methyl-2H-tetrazolc; 5-15-chloro-1-(3,4-dimethylphenyl)-1 H-pyrazol-4-yI]-2-niethyl-2F1-tetrazole; 5-[5-chloro-1-(3.4-dimethylphenyl)-1H-pyrazol-4-yfl-1 -methyl-2H-tetrazole; 5-[5-chloro-T -(3,5-dimethy!phenyl)-I H-pyTazol-4-yl]-2-rnethyl-211-telrazole; 5-[5-ehloro-1-(3.5-dirnethylphenyl)-1 H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-chloro-1 -(2-ethyiphenyl)-1FI-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5 -ebloro-1 -(2-ethyiphenyl)-11 I-pyrazol-4-yl]-1 -methyl-2H-tetrazolc; 5-[5-ehloro-1 -(4-ethylphenyl)-IH-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[5-ehloro-I -(4-ethylphenyl)-1 1-f-pyrazol-4-yl]-1-methyl-2H-tetrazole; 5-[5 -chioro-1 -(4-methoxyphenyl)-1 II-pyrazol-4-yl]-2-methyl-2H-tetrazo!e; 5-[5-chloro-1 -(4-methoxyphenyl)-1 H-pyTazol-4-yfl-1-methyl-211-tetrazole; 5-[5-chloro-I -(2-methylpheriyl)-1 H-pyrazoi-4-ylj-2-rnethyl-2H-tetrazole; 5-[5-chloro-1-(2-methylphenyl)-1H-pyrazol-4-ylJ-1-methyl-2H-tetrazole; 5-[5-chloro-I -(4-methylphenyl)-1 H-pyrazol-4-yI}-2-rncthyl-21-1-tetrazole; 5-[5-chloro-1 -(4-rnethylphenyl)-1 H-pyrazol-4-yll-1 -mcthyl-21-I-tctrazole; 5-(5-bromo-1-methyl-I H-pyrazol-4-yI)-2-methyl-2H-tetrazole; 5-(5 -brorno-1-methyl-i H-pyrazol-4-yl)-I -mcthyl-2H-tctrazole; 5-(5 -bromo-1 -ethyl-1 H-pyrazol-4-yl)-2-rnethyl-21 1-tetrazole; -(5-brorno-1 -ethyl-i H-pyrazol-4-yl)-1 -methy1-2H-tetrazoe; 5-[5-bromo-1 -(2-methyipropyl)-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-bromo-1 -(2-methyipropyl)-11-I-pyrazol-4-yl]-1 -methyl-2H-tetrazole; SKI -benzyh5-brorno-1H-pyrazoh4-yl)-2--methyl-2H-tetrazolc; 5-0 -benzyi-5-bromo-11 I-pyrazol-4-yl)-1 -rnethyl-21 1-tetrazole; 5-(5-bromo-1 -phenyl-1H-pyrazol-4-yl)-2-methyl-2E1-tetrazole; 5-(5-brorno-1 -phenyl-II-1-pyrazol-4-yl)-I-methyl-21-1-tetrazolc; 5-[5-bromo-I -(2-ehlorophenyl)-IH-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-bromo-1 -(2-ehloropheny-1 H-pyrazol-4-yI j-i -methyl-2H-tetrazole; 5-[5-brorno-l-(3-chlorophenyl)-1H-pyrazol-4-yl]-2-methyl-211-tetrazole; 5-5-bromo-i-(3-chloropheny1)-lH-pyrazo1-4-y1]-1-methy1-2H-ietrazo1e; 5-[5-bromo--(4-chiorophenyl)-H-pyrazol-4-ylJ-2-rnethyl-2H-tetrazole; 5-[5-bromo-1-(4-chlorophenyl)-H-pyraz&-4-yi]-I -mcthyl-21-T-tetrazole; 5-[5-bromo-1 -(2,3-dichlorophenyl)-III-pyrazol-4-yfl-2-methyl-2H-tetrazole; 5-[5-bromo-1-(2,3-dichlorophenyl)-IH-pyrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[S-bromo-1 -(2,4-dich1oropheny-I H-pyrazol-4-yl]-2-methyl-211-tetrazole; 5-[5-hromo-I -(2,4-dichlorophenyl)-1I I-pyrazol-4-y1]-i -methyl-2H-tetrazole; 5-[5-bromo-1 -( ,5-dichlorophenvD-I H-pyrazol-4-yfl-2-mcthyl-2H-tctrazolc; 5-[5-bromo-l-(2,5-dichlorophenyl) -lI-I-pyrazol-4-y1J-l-rnethyl-2H-telrazole; 5-[S-brorno-1-(2.6-dichlorophenyl)-IH-pyrazol-4-yI]-2-methy[-2H-tetrazole; 5-[5-bromo-1-(2,6-diehlorophenyl)-1 H-pyrazol-4-yI]-I -rnethyl-2H-tetrazole; 5-[5 -bromo-I -@ ,4-dichlorophcnyl)-1 H-pyTazol-4-yl]-2-methyl-2H-tetrazole; -[5 -bromo-1 -(3,4-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-brorno-l-(3,5-diclilorophenyl)-I H-pyrazol-4-ylj-2-rnethyl-2H-tetrazole; 5-[5-bromo-I -(3,5-dichlorophenyl)-IT-T-pyrazol-4-yl]-1-mcthyl-2H-tetrazole; 5-[5-bromo--(2-bromophenyl)-I H-pyrazol-4-yI]-2-methyl-211-tetrazole; 5-[5 -bromo-1 -(2-hromophenyl)-I iI-pyrazol-4-yll-1 -rnethyl-2H-tetrazole; 5-[5-bromo-1-(E-brornophenyl)-1H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[5 -bromo-1 -(3-bromophenyl)-1 II-pyrazol-4-yl] -1 -methyl-2H-tetrazole; 5-[5-brorno-1-(4brornopheny1)-1H-pyrazol-4-ylj-2-mcthyl-2H-tetrazole; 5-[5-bromo-l -(4-hromophenyl)-1I-1-pyrazol-4-yll-1-methyl-211-tetrazole; 5-[5-brorno-I -(4-fluorophenyl)-I H-pyrazol-4-ylj-2-niethyl-21-1-tctrazolc; 5-[5-bromo-I -(4-fluorophenyl)-I H-pyrazo!-4-yl]-I -methyl-211-tetrazole; 5-[5-brorno-1-(2-fluorophenyl)-IH-pyrazol-4-yl]-2-rnethyl-211-tetrazole; 5-[3-bromo--(2-fluorophenyl)-1H-pyrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[5-brorno-1-(2,3-dimethylphenyl)-1J-I-pyrazol-4-yI] -2-methyl-2H-tetrazole; 5-[5-hromo-I -(2,3-dirnethylphenyl)-1H-pvrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[5-bromo-1-(2,4-dimethylphenyl}-1H-pyrazol-4-yl]-2-methyl-2H-tctrazole; 5-[5-hromo-I -(2,4-diniethylphenyl)-1H-pyrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[5-bromo-1 -(2,5-dimethylphenyl)-I H-pyrazol-4-yl]-2-rnethyi-2H-tetrazoie; 5-[5-brorno-1 -(2,5-dimethyiphenyl)-1H-pyrazol-4-yfl-1 -mcthyl-211-tetrazole; 5-[5-brorno-1-(2,6-dimcthy1pheny)-1 H-pvrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-bromo-1-(2,6-dimethylphenyl)-1H-pyrazol-4-yi]-1-mcthyl-2H-tctrazole; 5-[5-brorno-1 -(3,4-dimethylphenyl)-1 H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-bromo-1-(3,4-dimcthylphenyl)-1H-pyrazol-4-yI]-1 -methyl-2H-tetrazole; 5-[5-bromo-I -@ ,5-dimethylphenyl)-1 H-pyrazol-4-yl]-2-rnethyl-2H-tetrazo Ic; 545-bromo-1-(3,5-dimethylphenyl)-1T-1-pyrazol-4-yl]-I -methyl-21-1-tctrazole; 5-[5-bromo-1 -(2-ethylphenyl)-11-1-pyrazol-4-ylj-2-methyl-2H-tetrazole; 5-[5-bromo-I -(2-ethylpheny[)-I I-I-pyrazol-4-yIj -1 -rnethyl-2H-tetrazole; 5-[5-brorno-1 -(4-ethylphenyl)-1H-pyrazol-4-yl]-2-methyl-211-tetrazole; 5-[5-hromo-I -(4-ethylphcnyl)-1H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-1I1-pyrazol-4-yl]-2-methyl-2H-tctrazolc; 5-[5-bromo-I -(4-methoxyphenyl)-iH-pyrazol-4-yl]-1-rnetliyl-2H-tetrazole; S-[5-brorno-1-(2-methylphcnyl)-1i1-pyrazol-4-yl]-2-methyl-2H-tetrazo!e; 5-[5-bromo-I -(2-methyiphenyl)-1H-pyrazol-4-yfl-I -methyl-2H-tctrazole; 5-[5-bromo-I -(4-methylphenyl)-IH-pyrazol-4-ylj-2-methyl-2F1-tetrazole; S-[5-brorno-1 -(4-mcthylphcnyl)-IH-pyrazol-4-yI]-I -rnethyl-2H-tetrazole; 5-(5-iodo-1-methyl-lI I-pyrazol-4-yl)-2-methyl-2H-tetrazole; 5 -(5-iodo-1-methyl-i I-I-pyrazol-4-yl)-1 -rnethyl-21 1-tetrazole; 5-(1 -ethyl-5-iodo-i H-pyrazol-4-yI)-2-methyl-21-T-tetrazole; 5-C -ethyl-5-iodo-I T-1-pyrazol-4-yI)-i -mcthyl-2H-tetrazole; 5-[5-iodo-1 -(2-methyipropyl)-1 H-pyrazo1-4-y1-2-rnethy1-2I 1-tetrazole; 5-[5-iodo-1-(2-methylpropyl)-1 H-pyrazol-4-yI]-I -methyl-21-I-tetrazolc; 5-(I-benzyl-5-iodo-1H-pyrazol-4-yl)-2-rnethyl-2H-tetrazole; 5-(1 -henzyl-5-iodo-1 H-pyrazo]-4-yl)-I -niethyl-2H-tetrazole; 5-(5-iodo-1-phenyl-1H-pyrazol-4-yl)-2-methyl-211-tetrazole; 5-(-iodo-1-phenyi-lH-pyrazo1-4-y1)-1-rnethy1-2H-tetrarzo1e; 5-{l -(2-chlorophenyl)-S-iodo-1I1-pyrazol-4-yl]-2-methy[-21-i-tetrazole; 5-[i-(2-clilorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-LI -(3-ch1oropheny)-5-iodo-I I-T-pvrazol-4-yIj-2-rnethyl-2H-tetrazole; 5-1i-(3-chlorophenyl)-5-iodo-1Ii-pyrazol-4-yll-1-methyl-2F1-tetrazole; 5-fl -(4-effloropheny)-5-iodo-I I-T-pyrazo]-4-yI]-2-methy]-2H-tetrazole; 5-[i-(4-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-methyl-2H-tetrazole; 5-[I -(2,3-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-2H-ietrazole; 5-[l -(2,3 -diehlorophenyl)-5 -iodo-1 H-pyrazol-4-yl] -1 -methyl-21-I-tctrazolc; 5-LI -(2,4-dichlorophenyl)-5-iodo-I H-pyra7ol-4-yIj-2-methyl-2H-tetrazole; 5-fl -(2,4-dichiorophcnyl)-5-iodo-1H-pyrazoi-4-yl]-1 -methyl-2H-tetrazo]c; 5-Li -(2,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yli-2-methyl-21H1-tetrazole; 5-[1-(2,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-rnethyl-2R-tetrazole; 5-[I -(2,6-dichlorophenyl)-5-iodo-I H-pyrazol-4-yI]-2-methy]-2H-tetrazolc; 5-[1 -(2,6-dich!orophenyl)-5-iodo-1 H-pyrazot-4-y[]-1 -methyl-2H-tetrazole; 5-[1-(3,4-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-fl -(3,4-diehlorophenyl)-5-iodo-1H-pyrazol-4-ylj-1-methyl-2H-tetrazole; 5-[1 -(3,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-mcthyl-211-tetrazole; 5-[1 -(3,5-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-1 -methyl-211-tetrazole; 5-[1 -(2-bromophcnyl)-5-iodo-1H-pyrazol-4-yl]-2-rncthyl-211-tctrazolc; 5-[1 -(2-bromophenyl)-5-iodo-1I1-pyrazol-4-yl]-i -methyl-21-]-tetrazole; 5-LI -(3-bromophenv!)-5-iodo-IH-pyrazol-4-yl]-2-rnethyl-2H-tetrazo!e; 5-[1 -(3-brornophenyl)-5-ioclo-1 H-pyrazol-4-yl]-i -methyl-2H-tetrazole; 5-[1 -(4-bromophenyl)-5 -iodo-I FI-pyrazol-4-yl] -2-methyl-21I-tetrazole; 5-11 -(4-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-i-methyl-2H-tetrazole; 5-L1-(4-fluorophcnyD-5-iodo-I H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-LI -(4-fluorophenyl)-5-iodo-IH-pyrazol-4-y!]-1 -methyl-211-tetrazole; 5-li -(2-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-Li -(2-iluorophenyl)-5-iodo--1 H-pyrazol-4-ylj -1-methyl -2H-tetrazole; 5-LI -(2,3-dimethylphenyl)-5-iodo-1II-pyrazol-4-yl]-2-methyl-2F1-tetrazole; 5-Li -(2,3-dirnethylphenyl)-5-iodo-1 H-pyrazol-4-yI]-I -methyl-2H-tetrazole; 5-Il -(2,4-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yi]-2-methyl-2H-tetrazoie; 5-[i-(2.4-dimethylphenyl)-5-iodo-iII-pyrazoi-4-yi}-i-metliyl-2H-tetrazole; 5-[i -(2,5-dirnethylphenyl)-5-iodo-IH-pyrazol-4-yl]-2-rncthyl-2H-tetrazole; 5-[1 -(2,5-dirnethylphenyl)-5-iodo-i II-pyrazoi-4-yll-1 -methyl-211-tetrazole; 5-[i -(2,6-dimethylphenyl)-5-iodo-I H-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[I -(2.6-diniethy1pheny-5-iodo-1 H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[1-(3,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[l-(3,4-dimethy1pheny-5-iodo-1 H-pyrazol-4-yl]-1 -niethyl-2H-tetrazole; 5-[1 -(3,5-dimethylphcnyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-11 -(3,5-dimethylphenyl)-5-iodo-1 H-pyraz&-4-ylj-I -methyl-2H-tetrazole; 5-[1 -(2-ethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-mcthyl-2H-tetrazole; 5-[1 -(2-ethylphenyl)-5-iodo-1II-pyrazol-4-yl]-1-methyl-2H-tetrazole; 5-[1 -(4-ethylphcnyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[ -(4-ethylphenyl)-5-iodo-1II-pyrazol-4-yl]-1-methyl-211-tetrazole; 5-[5-iodo-1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-2-methyl-2H-tetrazoie; 5-[5-iodo-1-(4-rnethoxyphenyl)-IH-pyrazo]-4-yl]-I -mcthyl-2H-tetrazole; 5-[5-iodo-I -(2-methyiphenyl)-I 1-1-pyrazol-4-yl] -2-methyl-21 1-tetrazole; 5-[5-iodo-l -(2-methyiphenyl)-1I-I-pyrazol-4-yij-1 -rnethyl-2H-tetrazole; 5-[5-iodo-1-(4-methylphenyl)-iH-pazo1-4-y]]-2-methyI-2H-tetrazoIe; 5-[5-iodo-1 -( -methylphenyl)-11-1-pyrazol-4-yl]-1 -methyl-211-tetrazole; 2-ethyl-S-( 1-methyl-I H-pyrazol-4-yl)-2H-tetrazole; 1-ethyl-5-(1-rnethyl-II-I-pyrazol-4-yl)-2H-tetrazole; 2-ethyl-5-( 1-ethyl-i H-pyrazol-4-yl)-2H-tetrazole; 1 -ethyi-5-(I -ethyl-I H-pyrazol-4-yl)-2H-tetrazole; 2-ethyl-5-[I -(2-rnethylpropyl)-1H-pyrazol-4-yl]-2H-tetrazole; I -ethyl-5-[I -(2-methylpropyl)-1 EI-pyrazol-4-yll -211-tetrazole; 5-( I -benzyl-U I-pyrazol-4-yl)-2-ethyl-21-1-tetrazole; 5-(1-benzyl-1H-pyrazol-4-y])-l-ethyl-2H-tetrazole; 2-ethyl-5-(l-phenyl-lH-pyrazol-4-yl)-211-tetrazole; 1 -ethyl-5-( I -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; 5-[i -(2-chlorophenyl)-1 H-pyrazoi-4-yl]-2-ethyl-2H-tetrazole; 5-{i -(2-chlorophenyl)-1H-pyrazol-4-yI]-I -ethyl-2H-tetrazole; 5-11 -(3-chlorophenyl)-1 II-pyrazol-4-yl]-2-ethyl-2H-letrazole; 5-[I -(3-chlorophenyl)-iH-pyrazol-4-yl]-I -ethy!-2H-tetrazolc; 5-[I -(4-chlorophenyl)-IH-pyrazol-4-yl]-2-ethyl-2U-telrazole; 5-[1 -(4-chlorophenyl)-1 I-I-pyrazol-4-ylj -I -ethyl-21-i-tetrazole; 5-[i -(2,3-dichlorophenyl)-1 H-pyrazol-4-yl]-2-ethyi-21 I-tetrazole; 5-[1 -(2,3-diehiorophenyl)-III-pyrazol-4-ylj-l-ethyl-2H-tetrazole; 5-[l -(2,4-dichiorophenyl)-I H-pyrazol -4-yl] -2-cthyl-2H-tctrazole; 5-[1 -(2,4-dichlorophenyl)-1H-pyrazol-4-yfl-1-ethyl-2H-tetrazole; 5-{l-(2,5-dichlorophenyl)-1 H-pyrazol-4-yfl-2-ethy-2H-tetrazo1e; -[1 -(2,5 -dichiorophenyl)-11 I-pyrazol-4-yfl-1 -ethyl-2F1-tetrazole; 5-[1 -(2,6-dichlorophenyl)-1 H-pyrazol-4-yfl-2-ethyk2H-tetrazole; 5-El -(2,6-dichlorophenyl)-1 FI-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[1 -(3,4-dichiorophenyl)-] !-1-pyrazol-4-ylj-2-ethyl-21-I-tetrazole; 5-[1 -(3,4-diehlorophenyl)-1H-pyrazol-4-yl]-1 -cthyl-2H-tetrazole; 5-[1-(3,5-dic.hlorophenyl)-1 H-pyrazo]-4-yfl-2-ethy-2H-ieirazoie; 5-Fl -(3,5-diehlorophenyl)-1 T-1-pyrazo]-4-yl]-I -ethyl-2H-tetrazole; 5-11 -(2-bromophenyl)-1 H-pyrazol-4-yll-2-ethyl-211-tetrazole; 5-[1-(2-bromophenyl)-1H-pyrazol-4-yl]-l-ethyl-2H-telrazole; 5-11 -( -broniophenyl)-1 1-1-pyrazol-4-yl]-2-cthyl-2H4etrazolc; S-fl -(3-hromopheny-1I1-pyrazo1-4-yI]-l -ethy!-21-I-tetrazole; 5-11 -(4-bromophenyl)-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[ I -(4-bromophenyi)-l H-pyrazol-4-yl j-l -cthy]-2H-tetrazole; 2-ethyl-S-Il -(4-fluorophenyl)-11 I-pyrazol-4-yfl-21 1-tetrazole; 1-ethyl-5-{1-(4-lluorophenyl)-1II-pyrazol-4-yfl-211-tetrazole; 2-ethyl-5-[1 -(2-fluorophcnyl)-1 H-pyrazol-4-yl] -2H-tctrazolc; 1-ethyl-S-Il -(2-fluorophenyl)-1 H-pyrazol-4-yl] -21-1-tetra.zole; 5-fl -(2,3-dirnethvlphenyt)-1 H-pyrazol-4-yI]-2-ethyl-2H-tetrazole; 5-[1 -(2,3-dimethylphenyl)-1H-pyrazol-4-yl]-I -ethyl-2H-tetrazolc; 5-[1 -(2.4-dimethylphenyl)-1Ii-pyrazol-4-yl]-2-ethyl-21-I-tetrazole; 5-1-(2,4-dimethy1pheny1)-1H-pyrazo1-4-y1]-1-ethy1-2l--1-tetrazole; 5-1-(2,5-dirnethy]phcnyI)-1 H-pyrazol-4-y!]-2-ethyl-2H-tetrazole; 5-[1 -(2,5-dimethylphenyl)-1 1I-pyrazol-4-yl]-1 -ethyl-211-tetrazole; 5-[1-(2,6-dimethylphenyl)-1H-pyrazol-4-ylJ-2-ethyl-2H-teftazole; 5-[l-(2,6-dirnethy1phenv1)-1Hpyrazo1-4-y1j-1-ethyl-2H-tetrazole; 5-[1 -,4-dimethy1phenyI)-11i-pyrazo1-4-y1]-2-ethy1-2iI-tetrazo1e; 5-{l -(3,4-dimethylphenyl)-IH-pyrazol-4-yIj-1-ethyl-2H-tetrazoie; 5-[l -(3,5 -dirnethylphenyl)-1H-pyrazol-4-yli-2-ethyl-21-l-tctrazole; 5-Fl -(3,5-dimethylphenyl)-1Ii-pyrazol-4-yl]-1-ethyl-2F1-tetrazole; 2-ethyl-S-LI -(2-ethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -ethyl-5-[1 -(2-ethyiphenyl)-1 1-1-pyrazol-4-yl]-2H-tetrazole; 2-ethyl-5-[1 -(4-ethylpheriyl)-I H-pyrazol-4-yl]-2H-Letrazole; -ethyl-5-[1 -(4-ethyIpheny)-1 1-I-pyrazol-4-yl] -211-tctrazole; 2-ethyl-5-[1-(4-rnethoxyphenyl)-1II-pyrazol-4-yl]-21-1-tetrazo]e; -ethyl-S -[1 -(4-methoxypheny)-1H-pyrazol-4-yl]-21-I-tetrazole; 2-ethyl-5-{1-(2-methylphenyl)-1I-I-pyrazol-4-yl]-2H-tetrazole; I-ethyl -5-El -(2-methylphenyl)-1 H-pyrazol-4-yl]-2H-tctrazole; 2-ethyl-5-[1 -(4-inethyiphenyl)-1H-pyrazol-4-yl]-21-I-tetrazole; 1-ethyl-5-[1-(4-methylphenyl)-IH-pyTazol-4-yl]-2H-tetrazole; 5-(5-ehthro-1 -methyl-1I-T-pyrazol-4-yl)-2-ethyl-21-I-tetrazole; S-(5-chloro-1 -methyl-IH-pyrazol-4-yl)-1 -ethyl-214-tetrazole; S-(5-chloro-1-ethyl-i H-pyrazol-4-yl)-2-ethyl-2H-tetrazole; 5-(5-chloro-1-ethyl-i H-pyrazol-4-y!)-I -ethyl-211-tetrazole; S-{5 -chioro-I -(2-methyipropyl)-1 H-pyrazol-4-yfl-2-ethyl-2H-tetrazole; S-[5-chloro-1-(2-metJiy1propy1)-1H-pyrazo1-4y1j-hethy1-2H-tctrazoIe; -benzyl-5-ehloro-I H-pyrazol-4-yl)-2-ethyl-211-tetrazole; 5-(1-bcnzyl-5-chloro-1H-pyrazol-4-yl)-1-etliyl-2H-telrazole; 5-(5-chloro-1-phenyl-IH-pyraz&-4-y])-2-ethyl-2H-tetrazole; 5-(5-eh loro-I -phenyl-I H-pyrazo1-4-y)-1 -ethyL-2H-tetrazole; 5-[5-chloro-1-(2-chlorophenyl)-1 T{-pyrazol-4-ylj-2-ethyl-2H-tetrazolc; 5-[S-chloro-l -(2-ehlorophenyl)-I}-I-pyrazol-4-yl]-1-ethyL-2H-tetrazole; 5 -[5 -ehioro-1 -@ -ehlorophenyl)-1 II-pyrazol-4-yfl-2-ethyl-2H-tetrazole; 5-[5-chloro-1 -(3-chlorophenyl)-IH-pyrazol-4-ylj-l -eihyl-2H-tetrazole; 5-[5 -chioro-1 -(4-ehlorophenyl)-1 H-pyrazol-4-yl J-2-cthyl -21-I-tetraz&e; 5-[5-chloro-1 -(4-chlorophcnyl)-i TJ-pyrazol-4-ylj-I -ethyl-211-tetrazole; 5-[5-ehloro-1 -(2,3-dichloropheny[)-1H-pyrazol-4-yl]-2-ethyl-2H-telrazole; 5-[5-chloro-1 -(2.3-dichlorophenyl)-1H-pyrazol-4-ylJ-1-ethyl-2H-tetrazok; 5-[5-chloro-1 -(2,4-diclilorophenyl)-H-pyrazol-4-yl]-2-ethy!-21-I-tetrazole; 5-[5-chloro-1-(2.4-diehloropheny!)-I I-I-pyrazol-4-yll-1-ethyl-2H-tetrazole; 5-[5-chloro-1-(2,5-dicblorophenyl)-i H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-I -(2,5-dich!orophenyl)-1H-pyrazol-4-yl]-1 -ethyl-2F1-tetrazole; 5-[5-chloro-1-(2,6-dichlorophenyl)-IH-pyrazol-4-yl] -2-ethyl-2F-1-tetrazole; 5-[5-chloro-1-(2,6-diehlorophenyl)-IH-pyrazol-4-yl]-1-cthyl-2H-tetrazole; 5-[5-chloro-1-(3,4-diehlorophenyl)-1II-pyrazol-4-yl] -2-ethyl-2F1-teirazole; 5-[5-eh1oro-1-(3,4-dich1oropheny1)-H-pyr'azol-4-yI]-I -ethyl-2H-tetrazole; 5-L5-chloro-I -(3,5-dichlorophenyl)-1H-pyrazol-4-yl]-2-ethyl-21I-tetrazole; 5-[5-chloro-1-(3.5-dicMorophenyl)-1H-pyrazol-4-yl]-1-ethyL-2H-tetrazole; 5-[1-(2-bromophenyl)-5-chloro-IH-pyrazol-4-yl]-2-ethyl-21-1-tetrazolc; 5-[1-(2-brornophcnyl)-5-ehloro-1H-pyrazol-4-yll-1 -eihyl-211-tetrazole; 5-11-(3-bromophenyl)-5-ehloro-IH-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[l -(3-hrornophenyl)-5-ehloro-1H-pyrazol-4-yl]-1-ethyl-211-tetrazole; 5-[1-(4-bromophenyl)-5-ehloro-1II-pyrazol-4-yl]-2-ethyl-2H-telrazole; 5-[1 -(4-broniophenyl)-5-ehloro-I H-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-ch1oro-1-(4-t1uoropheny)-1H-pyrazo-4-yfl-2-ethyI-2H-tetrazo1e; 5-[5-ehloro-1 -(4-fluoropheny)-1H-pyrazo-4-yfl--ethyl-2H-tetrazole; 5-[5-ehloro-I -(2-fluorophenyl)-I H-pyrazol-4-yll-2-ethyl-21-I-tetrazole; 5-[5-chloro-I -(2-fluorophenyl)-1 II-pyrazol-4-ylI-1 -ethyl-2H-tetrazole; 5-[5-chloro-I -(2,3-diinethylphenyl)-1H-pyrazoi-4-yl]-2-ethyl-2R-tetrazo!e; 5-[5-chloro-1 -(2,3-dimcthylphenyl)-I H-pyrazol-4-yfl-I -ethyl-211-tetrazole; 5-[5-chloro-1-(2,4-dirnethylphenyl)-1H-pyrazol-4-yl]-2-ethyl. -2H-tetrazole; 5-[5-chloro-1 -(2,4-dirnethyiphenyl)-H-pyrazol-4-yfl-I -ethyl-2T-I-tetrazole; 5-[5-chloro-I -(2,5-dirnethylphenyl)-1II-pyrazol-4-yl]-2-ethyl-2H-telrazole; 5-[5-chloro-1-(2.5-dimethy1pheny1)-1II-pvrao1-4-y1]-1-ethyl-2H-tetrazok; 5-[5-chloro-1 -(2.6-dimcthylphenyl)-11-I-pvrazol-4-yfl-2-cthyl-2H-tetrazole; 5-[5-ehloro-1-(,6-dimethylphenyl)-1II-pyrazol-4-ylj-1-ethyl-2H-Letrazo[e; 5-[5-chloro-1 -(3,4-dirnethylphenyl)-l H-pyrazol-4-yl]-2-cthyl-2H-tetrazole; 5-[5-chioro-1 -(3,4-dimethylphenyl)-1H-pyrazol-4-yl]-1-ethyl-211-tetrazole; 5-[5-chloro-l -(3,5-dimethylphenyl)-IFI-pyrazol-4-ylj-2-ethyl-2H-tetrazole; 5-[5-chloro-I -(3,5-diinethylphenyl)-IH-pyrazol-4-yl]-1-ethyl-2H-tetrazolc; 5-[5 -chioro-1 -(2-ethyiphenyl)-1 H-pyrazol-4-yl] -2-ethyl -21-1-tetrazole; 5-[5-chloro--1 -(2-ethyiphenyl)-1 1-T-pyrazol-4-yl]-1 -ethyl-2f1-tetrazole; 5-[5-chloro-I -(4-ethylphenyl)-1Ii-pyrazol-4-ylJ-2-ethyl-21-I-tetrazole; 5-[5-chloro-1-(4-ethylphenyl)-1H-pyrazol-4-yl]-l -ethyl-2H-tetrazole; 5-[5-ehloro--(4-rncthoxyphenyl)-I1-I-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-1-(4-methoxyphenyl)-IH-pyrazol-4-yfl-I -ethyl-2H-tetrazolc; 5-[5-chloro-1 -(2-rnethytphenyl)-1H-pyrazol-4-yl]-2-ethyl-211-tetrazole; 5-[5 -chloro-1 -(2-methyiphenyl)-1 IT-pyrazol-4-ylj-I -ethyl-2 H-tetrazole; 5-[5-chloro-1-(4-methylphenyD-I H-pyrazol-4-yfl-2-ethyl-2H-tetrazole; 5-[5-ehloro-I -(4-rnethylphenyl)-1 H-pyrazol-4-yfl-1 -ethyl-2H-tetrazole; 5-(5-bromo-1-methyl-1H-pyraz&-4-yl)-2-ethyl-2H-tetrazole; 5-(5-brorno-hrnethyl-1H-pyrazol-4-yl)-1-ethyl-2H-tetrazole; 5-(5-hromo-1-ethyl-I H-pyrazol-4-yI)-2-ethyl-2H-tetrazole; 5-(5-bromo-1-ethyl-1H-pyra2ol-4-yl)-1-ethyl-211-telrazole; 5-[5-bromo-1 -(2-rnethylpropyl)-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-brorno-1-(2-methylpropyl)-1TI-pyrazol-4-yll-1-ethyl-211-tetrazole; 5-LI -benzyT-5-bromo-1i-I-pyrazoi-4-yl)-2-ethyl-2H-tetrazole; 5-(1 -benzyl-5-bromo-1H-pyrazol-4-yl)-1 -ethyl-2H-tctrazole; 5-(5-bromo-I -phenyl-IT-I-pyrazol-4-yl)-2-ethyl-2H-tetrazole; 5-(5-bromo-1 -phenyl-1 H-pyrazol-4-yl)-1 -ethyl-2H-tctrazole; 5-[5-bromo-1 -(2-ch1oropheny1)-1i-I-pyrazo1-4y1]-2-ethy1-21-I-tetrazo1e; 5-5-broino-I -(2-chlorophenyl)-1H-pyrazol-4-yl]-1 -etliyl-2M-teftazole; 5-[5-bromo-1 -(3-ehlorophenyl)-1 t-I-pyrazol-4-yI]-2-ethyl-21-1-tetrazole; 5-[5-bromo-1 -(3 -chiorophenyl)-1II-pyrazol-4-yl]-1 -ethyl-2F1-tetrazole; 5-[5-bronio-1 -(4-ehiorophenyl)-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-brorno-I -(4-ehiorophenyl)-I H-pyrazol-4-yl]-1 -cthyl-2H-tetrazole; 5-[5-bromo-1-(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-2-ethyl-21-1-tetrazok; S-[5-bromo-1-(2,3-dichlorophenyl)-1H-pyrazol-4-ylj-I -cthyl-2H-tetrazole; 5-[5-bromo-1-(2,4-dichlorophcnyl)-1H-pyrazol-4-yl]-2-cthyl-2H-tctrazole; 5-[5-bromo-1-(2.4-dichlorophenyl)-11-i-pyrazol-4-ylj-I -ethyl-2H-tetrazole; 5-[5-bromo-I -(2,5-dichlorophenyl)-1H-pyrazol-4-ylIj-2-cthyl-2H-tctrazole; 5-[5-bromo-1 -(2.5-dichiorophenyl)-1H-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1-(2.6-dichlorophenyl)-IH-pyrazol-4-ylJ-2-ethyl-2H-letrazole; 5-[5-bromo-1-(2,6-dich1oropheny-1 H-pyrazol-4-yI]-1 -ethyl-2H-tetrazole; 5-[5-bronio-1-(,4-dichlorophcnyl)-IH-pyrazol-4-yI]-2-ethyl-2H-tetrazok; 5-[5-bromo-1 -(3,4-dichiorophenyl)-1II-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-brorno-1 -(3,5-dichlorophenyl)-1H-pyrazol-4-ylj-2-ethyl-2H-tctrazolc; 5-[5-brorno-1-(3,5-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -ethyl -2H-tetrazole; 5-[5 -bromo-I -(2-bromophenyl)-11 I-pyrazol-4-ylj -2-ethyl-2H-tetrazole; 5-[5-brorno-1-(2-brornophenyl)-1 H-pyrazol-4-y!]-1 -ethyl-21-1-tetrazole; 5-[5-hromo-1-(3-bromophenyl)-1H-pyrazol-4-ylJ-2-ethyl-2H-tetrazole; 5-[5-brorno-1-(3-brornophenyl)-1H-pyrazol-4-yI]-I -ethyl-2H-tetrazole; 5-{5-brorno-I -(4-bromophenyl)-IH-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-brorno-1 -(4-bromophenyl)-1 IT-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1-(4-fluorophenyl)-1 H-pyrazol-4-yl]-2-cthyl-2H-tctrazolc; 5-[5-brorno-I -(4-fluorophenyl)-I H-pyrazol-4-ylj-I -ethyl-2H-tetrazolc; 5-[5-bromo-1 -(2-fluorophenyl)-1II-pyrazol-4-yl]-2-ethyl-211-tetrazole; 5-[5-brorno-I -(2-fluorophenyl)-H-pyrazol-4-ylj-I -ethyl-2H-tetrazole; 5-[5-bromo-1 -(2,3-dimethylphenyl)-1Ii-pyrazol-4-yfl-2-ethyl-2H-tetrazole; S 545-brorno-1 -(2,3-dirnethylphenyl)-1 1-I-pyrazol-4-yIj-] -ethyl-2H-tetrazole; 5-[5-bromo-1 -(,4-dirnethy1pIienyl)-1H-pvrazo1-4-y1]-2-ethy1-2H-tetrazoIe; 5-{-bromo-1 -(2,4-diinethylphenyl)-1FI-pyrazol-4-yl]-1 -ethyl-211-tetrazole; 5-[5-bromo-1 -(2,5-dimethyiphenyl)-1H-pyrazol-4-yl]-2-ethyl-21-1-tetrazole; 5-[5 -bromo-1 -(2,5-dimethyiphenyl)-1 H-pyrazol-4-yl]-1 -ethyl-2f1-tetrazole; 5-[5-brorno-1-(2,6-dimethylphenyl)-1 H-pyrazol-4-yI]-2-ethyi-2H-tetrazole; 5-[5 -brorno-1 -(2,6-dirnethyiphenyl)-IH-pwazol-4-y!]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1 -(3,4-dimethylphenyl)-1 H-pyrazol-4-yI]-2-ethyl-2H-tetrazole; 5-[5-bromo-1 -(3,4-dirnethylphenyl)-11-1-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1 -(3,5-dirnethyiphenyl)-1 H-pyrazol-4-ylj-2-ethyl-2H-tetrazole; 5-[5-bromo-1 -(3,5-dimethylphenyl)-1 H-pyrazol-4-yI]-1-ethyl-2H-tetrazole; 5-[5-brorno-1-(2-ethylphenyl)-IH-pyrazol-4-yl]-2-ethyl-211-teurazole; 5-[5-brorno--(2-ethyIphenyI)-1 l-I-pyrazol-4-yI]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1--(4-cthylphenyl)-1 H-pyrazo1-4--y1]2-ethy1-2JJ-tetrazo1e; 5-[5-bromo-1-(4-ethylphenyD-1H-pyrazol-4-yl]-i-ethyl-2H-tetrazole; 5-[5-brorno-I -(4-methoxyphenyl)-I H-pyrazol-4-yl] -2-ethyl-211-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-1H-pyrazol-4-yl]-I -ethyl-2H-tetrazole; 5-[5-bromo-1-(2-methylphenyl)-1 H-pyrazol-4-ylj-2-e.thyl-2H-teirazole; 5-[5-bromo-] -(2-rnethylphenyl)-I H-pyrazo!-4-yI]-I -ethyl-2H-tetrazole; 5-[5-brorno-I -( -niethylphenyl)-I H-pyrazol-4-yfl-2-ethyl-21-1-tetraz&e; 5-[5 -bromo-I -(4-methyiphenyl)-I iI-pyrazol-4-yll -1 -ethyl-211-tetrazole; 2-ethyl-5-(5-iodo-1-methyl-1H-pyrazol-4-yl)-2H-tetrazole; 1-ethyl-5-(5-iodo-1-rnethyl-1 H-pyrazol-4-yI)-2H-tetrazole; 2-ethyl-5-( 1 -ethyl-5-iodo-11 I-pyrazol-4-yl)-2H-tetrazole; I -ethyl-5-( 1 -ethyl-5-iodo-1 H-pyrazol-4-yl)-21-T-tetrazole; 2-ethyl-5-[5-iodo-1-(2-rneflylpropyl)-1H-pyrazol-4-yl]-2F1-tetrazole; 1-ethyl-5-[5-iodo-1-(2-rnethylpropyl)-l I-T-pyrazol-4-ylJ-2H-tetrazole; 5-(I -henzyl-5-iodo-IH-pyrazol-4-yl)-2-cthyl-2H-tetrazole; 5-( I -benzyl-5-iodo-1 H-pyrazol-4-yl)-1 -ethyl-21 1-tetrazole; 2-ethyl-5-(5-iodo-1-phenyl-I H-pyrazol-4-yl)-2H-tetrazolc; 1-cthyl-5-(5-iodo-1-phenyl-1H-pyrazol-4-yl)-211-tetrazole; 5-[1 -(2-ehloropheny)-5-iodo-I H-pyrazcfl-4-yI]-2-ethyl-2H-tetrazolc; 5-[1 -(2-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-l-ethyl-2H-tetrazole; 5-[1 -(3-cfflorophenyl)-5-iodo-] H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; S 5-[l-(3-chlorophenyl)-S-iodo-1H-pyrazol-4-yll-1-ethyl-21-1-tetrazole; 5-[1-(4-chlorophenyl)-5--iodo-1I-1-pyrazol-4-ylj-2-ethyi-2H-tetrazole; 5-[1 -(4-chlorophenyl)-5-iodo-IH-pyrazol-4-yiJ-1 -cthyl-2H-tetrazole; 5-[1 -(2,3-dich1oropheny1)-5-iodo-l1-l-pyrazol-4-y1]-2-ethy-2H-tctraz&c; 5-41 -(2,3-dieh1oropheny1)-5-iodo-H-pyrazol-4-yI]-1 -ethyl-2Fi-tetrazole; S-[1 -(2,4-dichlorophenyl)-5-iodo4H-pyrazol-4-yl]-2-ethyl-2H-tetra2ole; 5-[l -(2,4-diclilorophenyl)-5 -iodo-1 H-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[1 (2,5-dich1oropheny1)-5-iodo-1 H-pyrazol-4-yl]-2-ethy[-2H-tetrazoie; 5-[ I -(2,5-clichlorophenyl)-5-iodo-1 H-pyrazol-4-yll-1 -ethyl-21I-tetrazole; 5-[1-(2,6-dichlorophenyl)-5-iodo-IFI-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[l-(2,6-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-1 -ethyl-21-I-tetrazole; 5-[1 -(3.4-dich1orophcny1)-5-iodo-1H-pyrazo1-4-yl-2-ethy1-2II-tetrazole; 5-[l -(3,4-dichlorophenyl)-5-iodo-IH-pyrazol-4-yI]-I -ethyl-2H-tetrazole; 5-[1 -(3,5-dichlorophenyl)-5-iodo-1lI-pyrazol-4-yl]-2-ethyl-211-tetrazole; 5-[1-(3,5-dichlorophenyl)-5-iodo-lH-pyrazol-4-ylj-I -elhyl-2H-tetrazole; 541 -(2-bromophenyl)-5-iodo-1 H-pyrazol-4-yIJ-2-cthyl-2H-tetrazole; 5-[1 -(2-brornophenyl)-5-iodo-I H-pyrazol-4-yI]-1 -ethyl-211-tetrazole; 5-[1 -(3-bromophenyl)-5-iodo-lI-l-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[l -(3-bromophenyl)-5-iodo-lH-pyrazol-4-yl]-1-ethyl-2H-tctrazolc; 5-[1 -(4-brornophenyl)-5 -iodo-}-I-pyrazol-4-yI]-2-ethyl-21l-tetrazole; 5-Ll-(4-broniophenyD-5-iodo-T H-pyrazo!-4-yl]-1-ethyl-211-tetrazole; 2-ethyl-S-Il -(4-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 1-ethyl-S-Il -(4-tluorophenyl)-5-iodo-IH-pyrazol-4-yI]-2H-tetrazole; 2-ethyl-5-[l-(2-fluorophenyl)-S-iodo-1II-pyrazol-4-yl]-2H-tetrazole; I -ethyl-5-[ 1 -(2-fluorophenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazolc; 5-[I -(2,3-clirncthylphenyl)-5-iodo-1I-I-pyrazol-4-yll-2-ethyl-2H-tetrazole; 5-[1-(2,3-dirnethylphenyl)-5-iodo-IH-pyrazol-4-yI]-I -ethyl-2H-tetrazole; 5-[I -(2,4-dimethylphenyl)-5-iodo-lI-l-pyrazol-4-yl]-2-ethyl-211-tetrazole; 5-[1 -(2,4-dirncthylphenyl)-5-iodo-1iI-pyrazol-4-ylJ-1 -ethyl-2H-tetrazole; 5-[l-(2,5-dimethylphenyl)-5-iodo-I H-pynzol-4-yl]-2-ethyl-2H-tctrazole; 5-[l -(2,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1 -ethyL2H-tetrazoie; 5-[i-(2,6-dirnethylphenyl)-5-iodo-I H-pyrazoi-4-yl]-2-ethyl-211-tetrazole; 5-11 -(2,6-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1-ethyl-2H-tetrazole; 5-11 -(3,4-dimethylphenyl)-5-iodo-IH-pyrazol-4-yI]-2-ethyl-2H-tetrazolc; 5-[l -(3.4-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl}-1-ethyl-211-tetrazole; 5-[1 -(3,5-dimcthylphenyl)-5-iodo-iI-1-pyrazol-4-yli-2-ethyl-2H-tetrazole; 5-[1-(3,5-clirneihylphenyl)-5-iodo-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 2-ethyl-5-[1 -(2-ethylphenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 1-ethyl-5-[i-(2-ethylphenyl)-5-iodo-I H-pyrazol-4-yI]-2H-tetrazolc; 2-ethyl-5-[i-(4-ethylphcnyl)-5-iodo-I T-I-pyrazol-4-yl]-211-tetrazole; I -ethyl-5-[I -(4-cthylphenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tetrazole; 2-ethyl-5-[5-iodo-1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -ethyl-5-[5 -iodo-1 -(4-rnethoxyphcnyl)-I H-pyrazol-4-yll-211-tetrazole; 2-ethy1-5-[5-iodo-1-(2-rnethy1pheny1)-1H-pyrazo1-4-y1]-2H-tetrazoe; i-ethy1-5-[5-iodo-1-(2-rnethdpheny1)-1H-pyrazoI-4-yl]-2H-tetrazo1e; 2-ethyl-5-[5-iodo-I -(4-methylphenyl)-iiI-pyrazol-4-yl]-2H-tetrazole; I -ethyl-5-[5-iodo-i-(4-mcthylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-(1 -methylethyl)-5 -(1-methyl-I H-pyrazol-4-yl)-2H-tetrazole; 1 -( I -methylethyl)-5-(1 -methyl-IH-pyrazol-4-yl)-2H-tetrazole; 5-(1-ethyl-1H-pyrazol-4-yl)-2-(1-methylethyl)-2H-tetrazole; 5-( 1-ethyl-i iI-pyrazol-4-yl)-1 -(1 -methylethyl)-2H-tetrazolc; 2-( 1 -methylethyl)-5 -[1 -(2-methyipropyl)-I H-pyrazol-4-yl]-21 1-tetrazole; 2-U -rnethylethyi)-5-[1 -(2-mcthylpropyl)-1 T-1-pyrazol-4-yll-21-I-tetrazole; 5-(l -benzyl-IH-pyrazol-4-yl)-2-(1-methylethyl)-2H-tetrazole; 5-(1 -benzyl-1H-pyrazol-4-yl)-1 -(1 -methylethyl)-2H4etrazole; 2-(1 -rnethylethyl)-5-( I -phenyl-I H-pyrazol-4-yl)-21-I-tetrazole; I -( I -methylethyl)-5-(1-phenyl-1H-pyrazol-4-yl)-2F1-tetrazole; 5-[i-(2-chlorophenyl)-1H-pyrazol-4-yIl-2-(I -methylethyl)-211-tetrazole; -(2-chlorophcnyl)-1H-pyrazol-4-yl]-1 -@ -rnethylethyl)-2H-tetrazole; 5-[1-(3-thlorophenyl)-1H-pyrazol-4-yI]-2-(1 -mcthylethyl)-21-I-tetrazole; 5-[ 1 -(3-ehlorophenyl)-1 H-pyrazol-4-yll -1 -(1 -methyiethyl)-211-tetrazole; 5-[1 -(4-chlorophenyl)-i II-pyrazol-4-ylj-2-( 1 -methylethyl)-2H-tetrazole; 5-[1 -(4-chlorophenyl)-1 H-pyrazol-4-ylj-1 -U -mcthylethyi)-2H-tetrazole; 5-[I -(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-2-(1-methylethyl)-2H-tetrazole; 5-11 -(2,3 -dichlorophenyl)-1 iI-pyrazol-4-yfl-1 -(1 -methylethyl)-21 1-tetrazole; 5-[1-(2.4-dichlorophenyl)-IH-pyrazol-4-yfl-2-(1-rnethylethyl) -211-teirazole; 5-11 -(2,4-dichlorophcnyl)-1 II-pyrazol-4-yll-1 -(1 -mcthylcthyl)-211-tctrazolc; 5-[1-(2,5-dichlorophenyl)-IIT-pyrazol-4-yl]-2-(1-rnethylethyl) -2H-tetrazole; 5-[1 -(2,5-dich!orophenyl)-IH-pyrazol-4-ylj-1-(1 -rnethylcthyl)-2H-tetrazole; 5-[1-(2,6-dichloroplienyl)-IH-pyrazol-4-yfl-2-(1-methylethyl) -2H-tetrazole; 5-[l-(2,6-diciiloroplienyl)-1 H-pyrazol-4-yI i-I --methy1e1hy1)-2H-tetrazoIe; 5-[l-(3,4-dichlorophenyl)-11T-pyrazol-4-yl]-2-(1-methylethyl) -21-1-tetrazole; 5-[1-(3,4-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -(i-methylelliyl)-2H-tetrazole; 5-[1-(3,5-dichlorophenyl)-1 H-pyrazol-4-yl]-2-(1 -mcthyiethyl)-2H-tetrazole; 5-[l -(3,5-dichloropheny!)-1 H-pyrazol-4-yl]-1 -@ -methylethyl)-21-1-tetrazole; 5-[1 -(2-brornophenyl)-IH-pyrazol-4-yl]-2-(1-rnethylethyl)-2H-tebazole; I -(2-bromophenyl)-I I-1-pyrazol-4-yl]-1 -o -niethylethyl)-2H-tetrazole; 5-11 -(3 -bromophenyl)-I H-pyrazol-4-yl]-2-( 1 -rnethylethyl)-2H-tetrazole; 5-[1 -(3-bromophenyl)-IIH-pyrazol-4-yl]-1-(1-rnethylethyl)-2H--tetrazole; 5-[ I -(4-bromophenyl)-I H-pyrazol-4-yl]-2-(I -methylethyl)-21 1-tetrazole; 5-[1-(4-bromophenyl)-1H-pyrazol-4-yl]-1-(1-rnethylethyl)-2H-tetrazole; 5-[1 -(4-fluorophenyl)-1 H-pyrazol-4-ylJ-2-( 1 -methylethyl)-2H-tetrazole; 5-[1 -(4-fluorophenyl)-I H-pyrazol-4-yl]-1 -(1 -rncthylethyl)-2H-tetrazole; 5-11 -(2-tluorophenyl)-1 H-pyrazol-4-yll-2-( 1 -rnethylethyl)-21-1-tetrazole; 5-L 1-(2-fluorophenyl)-1 i-i-pyrazol-4-ylj-i-(] -nieihyleihyl)-2H-tetrazole; 5-El -(2,3 -dirnethylphenyl)-1 H-pyrazol-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole; 5-[1 -(2,3-dimethylphenyl)-1 H-pyrazol-4-yl]-1 -o -methylethyl)-2H-tetrazole; 5-[1 -(2,4-dimethylphenyl)-1H-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[1-(2,4-dimethylphenyl)-1H-pyra2ol-4-yl]-1-(I-rnethylethyl) -2H-tetrazole; 5-[1 -(2,5-dimethylphenyl)-1 I-I-pyrazol-4-ylj-2-(1 -rnethylethyl)-211-tetrazole; 5-[1 -(2,5-dimethylphenyl)-1H-pyrazol-4-yl]-1-0 -methylethyl)-2H-tetrazole; 5-[1 42.6dimethy1pheny1)-I H-pyrazol-4-y1 j-2-(l-rnethyiethyl)-2H-tetrazole; 5-[1 -(2,6-dimethyiphenyl)-1H-pyrazol-4-yl]-1-0 -methylethyl)-21-1-tetrazole; 541 -(3,4-dimethylphenyl)-I H-pyrazol-4-y[]-2-(I -methylethyl)-21-1-tetrazole; 5-[I -(3,4-diniethylphenyl)-1H-pyrazol-4-yl]-1-(1-rnethylethyl)-2H-tetrazole; 5-[1 -(3,5-dimethylphenyl)-IH-pyrazol-4-ylj-2-(1 -rnethy1ethy-2H-tetrazo1e; 5-11 -(3,5-dirnethylphenyl)-I H-pyrazol-4-yI]-1 -0 -mcthylcthyl)-21-1-tctrazolc; 5-[1 -(2-ethylphenyl)-1 H-pyrazol-4-yfl-2-(I -methylethyl)-2H-tetrazole; 5-il -(2-ethylphenyl)-I R-pyrazol-4-y1]--(1 -methy1ethy)-2II-tetrazo1e; 5-[1-(4-ethylphenyl)-1 H-pyrazo1-4-y1i-2-(1-methy1ethy)-2H-tetrazole; 5-I I -(4-ethylphenyl)-l H-pyrazol-4-yl]-1 -(1-methylethyl)-2H-tetrazole; 5-[1 -(4-mcthoxyphenyl)-1H-pyrazol-4-yfl-2-(1 -methylethyl)-2H-tetrazole; 5-11 -(4-methoxyphenyl)-l H-pyrazol-4-yI]-1 -(1 -methylethyl)-2H-tetrazole; 2-cl -meihy!ethy!)-5-[1 -(2-methylphenyl)-1I-I-pyrazol-4-yl]-2H-tetrazole; 1 -(1 -methvlethyl)-5-[1-(2-methylphenyl)-1I-I-pyrazol-4-ylj-2h4etrazole; 2-( 1 -mcthylcthyl)-5-[ 1 -(4-methylphenyl)-1 H-pyrazol-4-yfl-211-tetrazole; 1-0 -methylethyl)-5-[1 -(4-methyiphenyl)-1II-pyrazol-4-ylj-2H-tetrazole; 5-(5-ch1oro-1-rnethy1-1H-pyra2o1-4-y1)-2-(1-methy1ethv-2H-tetrazoIe; 5-(5-ehloro-l -methyl-I H-pyrazol-4-yL)-1-0 -methylethyl)-211-tetrazole; 5-(5-chloro-1-ethyl-1H-pyrazol-4-yl)-2-(1 -rnethylelliyl)-2F1-tetrazole; 5-(5-ehloro-1-ethyl-IH-pyrazol-4-yl)-l -(1 -methylethyl)-2H-tetrazo!e; 5-[5-chloro-l -(2-methylpropyl)-lfI-pyrazol-4-yll-2-(1-methylethyl)-2H-tetrazole; 5-F5-chloro-1-(2-methylpropyl)-l H-pyrazol-4-yl}-1-(1-rnethylethyl)-2H-tetrazole; 5-(1-benzyl-5-chloro-1 H-pyrazol-4-yl)-2-(l -methylethyl)-21I-tetrazolc; 5-(l -henzyl-5-ch!oro-IH-pyrazol-4-yl)-1-(1-rnethylethyl)-21-1-tetrazole; 5-(5-chloro-1-phenyl-IJT-pyrazol-4-yl)-2-(l -methylethyl)-2H-tctrazole; 5-(5-chloro-l -phenyl-1}-T-pyrazol-4-yl)-1-(1-rnethylcthyl)-2H-tetrazole; 5-[5-ehloro-1-(2-ehlorophenyl)-1II-pyrazol-4-yl]-2-(1-methylethyl) -2H-ietrazole; 5-[5-chloro-1-(2-ehlorophenyl)-IH-pyrazol-4-yl]-l -0 -methylethyl)-2H-tetrazole; 5-[5-chloro-1 -(3 -ehiorophenyl)-1 H-pyrazol-4-yl]-2-(I -methylethyl)-21-I-tetrazole; 5-[5-chloro-i-(3-ehiorophcnyl)-l 1-T-pyrazol-4-yI]-1-(1-methylethyl)-2H-tetrazole; 5-[5-chloro-1 -(4-chiorophenyl)-1 H-pyrazol-4-yl] -2-( 1 -methylethyl)-2H-tetrazole; 5-[5-chloro-1-(4-chlorophenyl)-1H-pyrazol-4-ylj-i -o -methylethyl)-2H-tetrazole; 5-I5-chloro-1 -(2,3-diehlorophenyl)-l II-pyrazol-4-yll-2-(1-methylethyl)-2H-teirazole; 5-[5-chIoro-1-(2,3-dichloropheny1)-1H-pyrazo1-4-y1-1-(1-rnethylethy1) -2H-tetrazole; 5-[5-chloro-1 -(2,4-dichlorophcnyl)-1 H-pyrazol-4-yl]-2-(1-methylethyl)-211-tetrazole; 5-[5-cliJoro-1-(2.4-dichlorophenyl)-1II-pyrazol-4-ylj-1 -o -rnethylethyl)-2H-tetrazole; 5-[5-ch1oro-1-(2,5-dich1oropheny[)-lH-pyrazo1-4-y1-2-(1-methy1ethyl) -2H-tetrazo1e; 5-[5-ehloro-1 -(2,5-diehlorophcnyl)-1H-pyrazol-4-yl]-1 -(1-methylethyl)-21-I-tetrazole; 5-[5-ehloro-1-(2,6-dichlorophenyl)-IH-pyravol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[5-chloro-1 -(2,6-diehlorophenyl)-1H-pyrazol-4-yl]-1 -(1 -methylethyl)-2H-tetrazole; 5-[5-chloro-1-(3,4-dichlorophenyl)-1iI-pyrazol-4-ylj-2-(1 -methylethy!)-2H-tetrazole; 5-[5-chloro-1 -(3.4-dichlorophenyl)-I H-pyrazol-4-ylj-1 -u -nicthylcthyl)-2H-tetrazole; 5-[5-chloro-1 -(3,5-dichiorophenyl)-1I-I-pyrazol-4-yl]-2-(1-rnethylethyl)-2H-ietrazole; 5-[5-chloro-I -(3.5-dichlorophenyl)-] H-pyrazo!-4-yI]-1 -o -methylethyl)-21-1-tetrazole; 5-[1 -(2-bromophenyl)-5-chloro-1II-pyrazol-4-yll-2-(1 -rncthylcthyl)-2H-tetrazole; 5-{1-(2-brornophenyl)-5-chloro-1Ii-pyrazol-4-yfl-1-(1-rnethylethyl) -21-1-tetrazole; 5-[l-(3-bromophenyl)-5-chloro-1 H-pyrazol-4-yI]-2-(1 -methylethyl)-2H-tetrazole; 5-[1-(3-bromophenyl)-5-chloro-IH-pyrazol-4-yl]-1-(1-methylethyl) -2H-tetrazole; 5-11 -(4-hrornophenyl)-5-chloro-1 H-pyrazol-4-ylj-2-( 1 -rncthylcthyl)-2H-tctrazolc; 5-[1 -(4-bromophenyl)-5-chloro-1H-pyrazol-4-yl]-1-0 -methylethyl)-2H-tetrazole; 5-[5-cIiloro-1-(4-fluoropheny1)-1F1-pyrazo1-4-y1j-2-(1-methy1e. thy-2FT-tetrazo1e; 5-[5-chloro-1-(4-[luorophenyl)-11-1-pyrazol-4-yl]-1-(1-rnethylethyl) -2H-tetrazolc; 5-[5-chloro-1 -(2-fluorophenyl)-111-pyrazol-4-yfl-2-(1-methylethyl)-211-tetrazole; 5-[5-chloro-1-(2-fluorophenyl)-1H-pyrazol-4-ylJ-1 -0 -methylethyl)-2H-lei.razole; 5-L5-chloro--(2,3-dirncthylphenyl)-1 H-pyrazol-4-yI]-2-(1 -methylethyl)-2H-tetrazole; 5-15-ch1oro-1-(2,3-dimethy1pheny-11I-pyrazo1-4-y1]-1-(1-rnethy1ethy1) -2H-tetrazo1e; 5-[5-chloro-1-(2, 4-dirnethy1pheny1)-1H-pyrazo1-4-y1j-2-(1-mcthyIcthy-2H-tctrazo1e; 5-L5-chloro-1-(2, 4-dirnethyipheny])-] H-pyrazol-4-yI]--o -niethyIcthy-2H-tctrazoIe; 5-[5-ch1oro 1 -(2,S-dirnethylphenyl)-1H-pyrazol-4-yl]-2-(1 -mcthylcthyl)-2H-tetrazolc; 5-[5-chloro-1 -(2.5-dimethylphenyl)-1 H-pyrazol-4-ylj-1-( 1 -rnethylethyl)-2H-tetrazole; 5-[5-chloro-1 -(2,6-dirnethylphenvl)-1H-pyrazol-4-yl]-2-(1-mcthylcthyl)-2H-tctrazole; 5-[5-chloro-1 -(2,6-dimethylphenyl)-1H-pyrazol-4-yl]-1-(1 -methylethyl)-211-tetrazole; 5-[5-chloro-1 -(3,4-dirnethylphenyl)-1FI-pyrazol-4-ylJ-2-(1 -methylethyl)-2H-tetrazole; 5-[5-chloro-1-(3,4-dirnethylplienvl)-l 1-T-pyrazoi-4-yI]-1 -o -rnethyIethy-2T-I-tetrazo1e; 5-[5-chloro-1 -(3,5-dirncthylphcnvl)-1 H-pyrazol-4-yl]-2-(1 -niethylethyl)-2T-1-tetrazole; 5-[5-chloro-1 -(3.5-dimethylphenyl)-1II-pyrazol-4-yli-1-(1 -rnethylethyl)-21-I-tetrazole; 5-[5-chloro-1 -(2-ethylphenyl)-1H-pyr'azol-4-yl]-2-(1 -methylethyl)-2H-tetrazo]c; 5-[5-chloro-I -(2-cthylphcnyl)-1 H-pyrazol-4-yI]-1 -(1 -methylethyl)-2H-tetrazole; 5-[5-cliloro-1-(4-ethylphenyl)-1H-pyrazol-4-yl]-2-(1 -methylethyl)-2H-teftazole; 5-[5-chloro-I -(4-ethyipheny!)-I T-1-pyrazol-4-y!1-1-0 -methylethyl)-211-tetrazole; 5-5-ch1oro-1-(4-methoxypheny1)-1H-pyrazo1-4-y1I-2-(1 -methylethyl)-2H-tetrazole; 5-[5-chloro-1-(4-rnethoxyphenyl)-1H-pyrazol-4-ylj-1-(1-niethylethyl) -2H-tetrazole; 5-[5-chloro-I -(2-methylphenyl)-1H-pyrazol-4-yl]-2-(1-rncthylethyl)-2H-tetrazole; 5-[5-chloro-1 -(2-methylphenyl)-1II-pyrazol-4-yl]-1 -(1 -rnethylethyl)-2H-tetrazole; 5-[5-chloro-l -(4-methylphenyl)-1 H-pyrazol-4-yl]-2-(1-mcthylcthyl)-2H-tctrazolc; 5-[5-chloro-1 -(4-methylphenyl)-1H-pyrazol-4-ylI-1 -(1 -rnethylcthyl)-2H-tetrazole; 5-(5-bromo-I -methyl-1H-pyrazol-4-yl)-2-(1 -methylethyl)-2H-tetrazole; 5-(5-bromo-1 -methyl-1H-pyrazol-4-yl)-1-(1 -methylcthyl)-2H-tetrazole; 5-(5-hrorno-1 -ethyl-1II-pyrazol-4-yl)-2-(1 -methylethyl)-211-tetrazole; 5-(5-bromo-1 -ethyl-1H-pyrazol-4-yl)-1 -(1 -methylethyl)-2H-tetrazole; S-[5-bromo-l -(2-methyipropyl)-I H-pyrazol-4-yI]-2-(1 -nicthylethyl)-21-T-tetrazolc; 5-[5-bromo-1 -(2-rnethylpropyl)-1 H-pyrazo1-4-yIj-1-(1-methy1eihy1)-2H-tetrazo1e; 5-(1-henzyl-5-bromo-1I1-pyrazol-4-yl)-2-(1 -methylethyl)-211-tetrazole; -0 -benzyl-5-bromo-1I-I-pyrazol-4-yl)--1-(1 -methylethyl)-2H-tetrazole; 5-(5-bromo-1 -phenyl-1 H-pyrazol-4-yl)-2-(i -methylethyl)-2H-tetrazole; 5-(5-bromo-1 -phenyl-1 H-pyrazol-4-yI)-1 -(I -mcthylethyl)-21-1-tetrazole; 5-[5-bromo-1 -(2-chlorophenyl)-1H-pyrazol-4-y1]-2-(1 -methylethyl)-2R-tetrazole; 5-15-bronio-1-(2-chlorophenyl)-1H-pyrazol-4-ylj-1 -(1 -methylethyl)-21-I-tetrazole; 5-[5-brorno-1 -(3-cblorophenyl)-1H-pyrazol-4-yl]-2-(1-methylethyl)-2H-tetrazole; 5-[5-bromo-1-(3-chloropheny1)-1II-pyrazo1-4-y1-1-(1-methy1ethy1) -2H-tetrazo1e; 5-[5-hromo-I -(4-chlorophenyl)-1 H-pyrazol-4-y[]-2-(l -rnetFiylethyl)-2H-tctrazolc; 5-[5-bronio-I -(4-chlorophenyl)-1 H-pyrazo!-4-yl]-1 -(1 -rnothylcthyl)-2H-tetrazolc; 5-[5-bromo-1-(2,3-dichlorophenyl)-1H-pyrazol-4-yI]-2-(1 -rnelhylethyl)-2H-telrazole; 5-[5-bromo-1-(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-1 -(1 -rncthylcthyl)-21-T-tctrazole; 5-[5-bromo-1 -(2,4-dichlorophenyl)-1 T1-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetraz.ole; 5-[5-bromo-1 -(2,4-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -o -methylethyl)-2H-tetrazole; 5-[5-bromo-1 -(2,5-diclilorophenyl)-1H-pyrazol-4-ylj-2-(1-rncthylethyl)-2H-tetrazole; 5-[5-bromo-1-(2,5-dichlorophenyl)-H-pyrazol-4-yI]-1 -o -methylethyl)-21-1-tetrazole; 5-[5-hroino-1 -(2,6-dichlorophenyl)-1II-pyrazol-4-yl]-2-(1-methylethyl)-2H1elrazole; 3-[5-brono-1 -(2,6-dichlorophenyl)-IH-pyrazol-4-yl]-1-(1-rnethylethyl)-2Fi-tetrazolc; 5-[5-hromo-I -(3,4-dichlorophenyl)-1 H-pyrazol-4-yI]-2-(1 -mcthylcthyl)-211-tctrazole; 5-[5-hromo-1 -(3.4-dichlorophenyl)-1H-pyrazol-4-yll-1-(1 -inethylethyl)-211-tetr'azole; 5-[5-brorno-1 -(3,5-dichlorophenyl)-l H-pyrazol-4-yl]-2-(1-rnethylethyl)-2H-tetrazole; 5-[5-hromo-1 -(3,5-didhiorophenyl)-1H-pyrazol-4-yll-1 -o -methylethyl)-2H-tetrazole; 5-[5-bromo-1-(2-bromophenyl)-1H-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-{5-bromo-1-(2-brornophenyl)-1 H-pyrazol-4-yl]-1 -o -rnethylethyl)-2H-tetrazole; 5-[5-bromo-1 -(3-hromophenyl)-111-pyrazol-4-yl]-2-(1-methylethyl)-2H-tetrazole; 5-5-bromo-1-(3-brornophenyl)-1H-pyrazo1-4-y1]-1-(] -methylcthyl)-2H-tetrazole; 5-[5-brorno-1 -(4-bromophenyl)-1 H-pyrazol-4-yfl-2-(1 -methylethyl)-2H-tetrazole; 5-[5-bromo-1-(4-brornophenyl)-IH-pyrazol-4-vlj-i-(1 -mcthylethyl)-2H-tetrazole; 5-L5-bromo-1 -(4-fiuorophenyl)-1 H-pyrazol-4-yll-2-(1-methylethyl)-2H-leUTazole; 5-15-bromo-1-(4-fluorophenyl)-1H-pyrazol-4-y1]-1-(1-incthylethyl) -2H-tetrazole; 5-[5-brorno-1-(2-Iluorophenyl)-IH-pyrazol-4-yl]-2-(1 -methylcthyl)-211-tetrazole; S 5-[5-brorno-1 -(2-fluorophenyl)-1H-pyrazol-4-yl]-1-(1-methylethyl)-2F1-tetrazole; 5-[5-brorno-1-(2,3-dimethylpheuyl)-1II-pyrazol-4-ylj-2-(1 -methylethyl)-2H-tetrazolc; 5-[5-brorno-1 -(2,3-dimethylphenyl)-1 H-pyrazol-4-yl]-1-(1 -methylethyl)-21I-teirazole; 5-[5-bromo-1 -(2,4-dirnethyiphenyl)-1I-I-pyrazol-4-yl]-2-( I -metl-iylethyl)-2H-tetrazole; 5-[3-bromo-1 -(2.4-dimethyiphenyl)-I H-pyrazol-4-yl]-1 -(1 -rnethylcthyl)-2H-tetrazole; 5-[5-brorno-1-(2,5-dinicthylphenyl)-1H-pyrazol-4-yI]-2-(1 -inethylethyl)-211-tetrazole; 5-[5-bromo-I -(2,5-dimethylphenyl)-1II-pyrazol-4-ylj-1-(1-rnethylethyl)-2H-tetraz&c; 5-[5-brorno-1 -(2,6-dimethylphenyl)-IH-pyrazo]-4-yI]-2-(1 -methylethyl)-211-tetrazole; 5-{5-brorno-1-(2,6-dirnethypheny1)-1 U-pyrazol-4-yfl-1-(1--rnethylethyl)-2H-tetrazole; 5-[5-bromo-1 -(3,4-dirnethylphenyl)-IH-pyrazol-4-yl]-2-(1 -rnethy]ethyl)-2H-tetrazo[e; 5-[5-brorno-1-(3.4-dirnethy1pheny1)4H-pyrazo-4-y1]-l -(1 -methylethyl)-211-tetrazole; 5-5-brorno-1-(3,5-dimethyIpheny-1 TI-pyrazol-4-yll-2-(1-methylethyl)-2H-tetrazole; 5-[5-bromo-I -(3,5-dimcthylphcnyl)-1I-I-pyrazol-4-ylI]-1-(1 -rnethylethyl)-2H-tetrazole; 5-[5-bromo-1-(2-ethy1pheny-1 1-T-pyrazol-4-ylj-2-(1-methylethyl)-2H-tetrazole; 5-[5 -bromo-1 -(2-ethylphcnyl)-1 H-pyrazol-4-yl]-1 -(1 -methylethyl)-211-tetrazole; 5-[5 -bromo-1 -(4-ethyiphenyl)-1 II-pyrazol-4-ylj-2-( 1 -methy!ethyl)-2H-tetrazolc; 5-[5 -bromo-1 -(4-ethyiphenyl)-1 H-pyrazol-4-yfl -i-(I -rnethylethyl)-2H-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-1 H-pyTazol-4-yl]-2-(1-methylethyl)-211-tetrazole; 5-[5-bromo-1 -(4-rnethoxyphcnyl)-1 T-I-pyrazol-4-yfl-1-(1-methylethyl)-2H-tetrazole; 5-[5-bromo-1 -(2-methylphenyl)-1H-pyrazol-4-yl]-2-(1 -rnetliylethyl)-2H-tctrazole; 5-[5 -bromo-I -(2-methyiphenyl)-1R-pyrazol -4-yl]-1 -(1 -methylethyl)-211-tetrazole; 5-L5-brorno-1 -(4-rnethylphenyl)-IIT-pyrazol-4-yl]-2-(1-methylethyl)-211-tetrazole; 5-[5-bromo-1-(4-methylphenyl)-1H-pyrazol-4-yl]-1-(i-methylethy!) -2H-tetrazole; 5-(5-iodo-1-methy1-1H-pazoi-4-yI)-2--methylethyl)-2utetrazole; 5-(5-iodo-1-mcthyl-1H-pyrazol-4-yl)-1-(1-methylethyl)-2H-tetrazole; 5-(1 -ethy1-S-iodo-1H-pyrazo1-4-y-2-(1 -methylethyl)-211-tctrazole; 5-(1-ethyl-5-iodo-1 H-pyrazol-4-yl)-1-(1 -methylethyl)-211-letrazole; 5-[5-iodo-1-(2-methylpropyl)-1H-pyrazol-4-yIj-2-(1 -rnethylethyl)-21-1-tctrazole; 5-[5-iodo-1-(2-methylpropyl)-1 H-pyrazol-4-yl]-1-(1-methylethyl)-2111-tetrazole; 5-(1 -benzyl-5-iodo-1H-pyrazol-4-yl)-2-(1-methylethyl)-2H-Leirazole; 5-(i-beiy1-5iodo1H-pyraz&-4-y)-1-(1 -methyiethyl)-2H-tetrazole; 5-(5-iodo-I -phenyl-I II-pyrazol-4-yl)-2-(i -methylethyl)-2H-tetrazole; 5-(5-iodo-1-phenyl-iH-pyrazol-4-yl)-1-(1-rnethylethyl)-2H-tetrazole; 5-[l -(2-chloropheny])-5-iodo-1 H-pyrazo!-4-yI]-2-(1 -methylethyl)-211-tetrazole; 5-[1 -(2-chlorophcnyl)-5-iodo-IH-pyrazol-4-yl]-1-(I -rnethylethyl)-2H-tetrazole; 5-[I -(3-chlorophenyl)-5-iodo-iH-pyrazol-4-yIj-2-(i -rnethylethyl)-2H-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-IH-pyrazol-4-yl]-1-(i-rnethylethyl)-2H-tetrazole; 5-[i-(4-chloroplienyl)-5-iodo-I T-i-pyrazol-4-yl]-2-( I -rnethylethyl)-2H-tetrazolc; 5-[ I -(4-chlorophenyl)-5-iodo-1 H-pyrazol-4-yfl-i -o -methylethyl)-2H4etrazole; 5-[1 -(2,3-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2-(1-rnethyleihyl) -2H-tetrazole; 5-[1 -(2,3-dichlorophenyl)-5-iodo-11-i-pyrazo!-4-yI]-i-(1-methylcthyl) -2H-tetrazole; 5-Li -(2,4-dichlorophenyl)-5-iodo-I I-I-pyrazol-4-yl]-2-(i-methylethyl)-21-1-tetrazoie; 5-41 -(2,4-dichlorophenyl)-5-iodo-1II-pyrazol-4-yil-i-(1-methylethyl) -2H-tetrazoie; 5-[i -(2,5-dichlorophenyl)-5-iodo-1}-1-pyrazoi-4-ylj-2-(1 -rnethylethyl)-2H-tetrazole; 5-1-(2,5-dic1i1orophenyI)-5-iodo-I H-pyrazol-4-yI]-1 -(1-methyiethyl)-2II-tetrazole; 5-[1-(2,6-dich1orophenyi)-5-iodo-1H-pyrazo1-4-y1-2-(i-rneihyiethy1} 2H-tetrazoIc; 5-[i-(2,6-dichlorophenyl)-5-iodo-1H-pyrazol-4-yi]-i-(i-methyiethyl) -2H-tetrazole; 5-[i -(3,4-dichlorophenyl)-5-iodo-JH-pyrazoi-4-yl]-2-(i -rncthylethyl)-2H-tetrazoie; 5-[I-(3.4-diehlorophenyl)-5-iodo-iII-pyrazoi-4-vl]-1 -(i-methylethyl)-2H-tetrazole; 5-[I -(3.5-diehlorophenyi)-5-iodo-I H-pyrazol-4-yI]-2-(1 -methyiethyl)-2H-tetrazole; 5-[i-(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-l -(1-methylethyl)-2H-tetrazole; -[ I -(2-bromophenyl)-5-iodo-i H-pyrazol-4-yi] -2-( 1 -methyiethyl)-2H-tetrazole; 5-[1 -(2-bromophenyl)-5-iodo-iH-pyrazol-4-yI]-1 -(1 -rnethylethyl)-2H-tetrazoic; 5-[i -(3-bi'ornophenyl)-5-iodo-H-pyrazol-4-y]]-2-(1 -methyiethyl)-21I-tetra.zoie; 5-Li -(3-bromophenyl)-5-iodo-1II-pyrazol-4-yl]-1 -(1-methyiethyl)-21-i-tetrazole; 5-i-(4-brornopheny1)-5-iodo-1H-pyrazo1-4-y1i-2- (1-rnethy1ethyD-2H-tetrazoIe; 5-[1 -(4-bromophenyl)-5-iodo-l H-pyrazol-4-yl]-1 -@ -methylethyl)-211--tetrazoie; 5-[I -(4-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(1 -niethyiethyl)-2H-tetrazolc; 5-[1 -(4-fluorophenyl)-5-iodo-1 I-I-pyrazol-4-yl]-1 -(1 -methyiethyl)-2H-tetrazole; 5-fl -(2-fluorophenyl)-5-iodo-iH-pyrazol-4-ylJ-2-(1 -rnethylethyi)-2H-tetrazole; 5-[1 -(2-fluorophenyl)-5-iodo-ilHf-pyrazol-4-ylj-I -(I -rnethylethyl)-2H-tetrazole; 5-Li-(2,3-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-(1 -methylethyi)-21I-tetrazoie; 5-[I -(2,3-dirnethylphenyl)-5-iodo-iII-pyrazol-4-yl]-i-(i-methylethyl) -2H-tetrazole; 5-[1-(2,4-dimethyiphenyl)-5-iodo-I H-pyrazol-4-yl]-2-(i-mcthylethyl)-2H-tetrazole; 5-11 -(2,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1-(1-methylethyl) -2U-tetrazole; 5-[ -(2,5-dimethylphenyl)-5-iodo-i1-l-pyrazol-4-yfl-2-(1 -methylethyl)-2H-tetrazo!e; 5-[1 -(2,5-dimethylphcnyl)-5-iodo-1 H-pyrazol-4-yI]-1 -(1 -methylethyl)-2T-I-tetrazole; 5-[1-(2,6-dimethyiphenyl)-5-iodo-IT-I-pyrazol-4-yIl-2-(1-methylethyl) -211-tetrazole; 5-[1-(2,6-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1-(1 -rnethylethyl)-2H-tetrazole; 5-[I -(3,4-dimethylphenyt)-5-iodo-1 H-pyraz&-4-yl]-2-(1 -methylethyl)-21-I-tetrazole; 5-[1-(3,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1-(i -methyleihyl)-2H-tetrazole; 5-[1 -(3,5-dimethy!phenyl)-5-iodo-IH-pyrazoi-4-yI]-2-(1 -methylethyl)-211-tetrazole; 5-[1-(3,5-dimethylphenyl)-S-iodo-1II-pyrazol-4-yl]-1-(1-methylethyl) -2H-tetrazole; 5-[i-(2-ethylphenyl)-5-iodo-IH-pyrazol-4-ylJ-2-(1-methylethyl) -21-l-tetrazole; 5-[1 -(2-ethylphenyl)-5-iodo-1 1-1-pyrazo[-4-yI]-1 -(1 -methylethyl)-21-T-tetrazole; 5-[1-(4-ethylphenyl)-5-iodo-1FI-pyrazol-4-yI]-2-(1 -methylethyl)-211-tetrazole; 5-[1-(4-etliylphenyi)-5-iodo-1 H-pyrazol-4-yIj-l-(I -niethylethyl)-2H-tetrazole; 5-{5-iodo-1 -(4-methoxyphenyl)-11-I-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-15-iodo-1 -(4-methoxyphenyl)-1H-pyrazol-4-ylhI-1 -(I -rnethylethyl)-2H-tetrazole; 5-[5-iodo-1 -(2-methylphenyl)-T H-pyrazol-4-yI]-2-(1 -rnethylethy!)-2F1-tetrazole; 5-[5-ioclo-1-(2-rncthylphcnyl)-1 T-I-pyrazol-4-yJ]-1 -o -rnethylethyl)-21-1-tetrazole; 5-[5-iodo-1-(4-methylphenyl)-1H-pyrazol-4-yl]-2-(1-rnethylethyl) -2H-tetrazole; 5-L5-iodo-1-(4-niethyiphenyD-I H-pyrazol-4-y]]--o -methy]ethyl)-2T-1-tetrazole; 2-benzyl-5-(1 -methyl-lI I-pyrazol-4-yl)-21 1-tetrazole; 1 -benzyl-5-( 1-methyl-I H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-(1 -ethyl-I H-pyrazol-4-yl)-2H-tetrazole; I -benzyl-5-( 1-ethyl-i II-pyrazol-4-yl)-21 1-tetrazole; 2-benzyl-5-[1 -(2-rnethylpropyl)-1 H-pyrazol-4-ylj-2H-tetrazole; l-benzyl-5-[J -(2-methylpropyl)-1 H-pyrazol-4-yI}-21-I-tetrazole; 2-benzyl-5-( I -benzyl-1 H-pyrazol-4-yl)-2H-tetrazole; 1-benzyl-5-(l-benzyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-S -(1 -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; 1 -benzyl-5-( 1 -phenyl-I 1-I-pyrazol-4-yl)-2H-tetrazole; 2-benzyl -5-[ I -(2-ehiorophenyl)-I H-pyrazoi-4-yl] -2H-tetrazole; I -benzyl -5-[ I -(2-chlorophenyl)-1 I-I-pyrazol-4-yli -2I1-tetrazoie; 2-benzyl-5-[1 -(3-chlorophenyl)-1}1-pyrazol-4-yl]-2H-tctrazolc; 1 -benzyl-5-[1 -(3 -ehiorophenyl)-I H-pyrazol -4-yl] -2H-tetrazole; 2-benzyl-5-[I -(4-chiorophenyl)-1 H-pyrazol-4-yl] -2H-telrazole; -benzyl-5-[1 -(4-chlorophenyl)-H-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[1 -(2,3-dichiorophenyl')-1II-pyrazol-4-yl]-211-tetrazole; I -benzy1-5-1 -(2,3-dichiorophenyl)-IH-pyrazol-4-ylj-2H-tetrazole; 2-henzyl-5-{1 -(2,4-dichlorophenyl)-1 H-pyrazol-4-y[]-2H-tetrazole; 1-benzyl-5-[1 -(2,4-dielilorophenyl)-IH-pyrazol-4-yl]-2H-tetrazole; 2-berizyl-5-[1 -(2,5-dielilorophenyl)-I H-pyrazol-4-ylj-2H-tetrazole; 1-benzyl-5-[1 -(2.5-diehlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazolc; 2-benzy[-54] -(2,6-diehiorophenyl)-] H-pyrazol-4-yIj-2H-tetrazole; 1 -benzyl-5-[1 -( ,6-diehlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazolc; 2-benzyl-5-[1 -@ ,4-dichlorophenyl)-1 I I-pyrazol-4-yll-21 1-tetrazole; 1 -benzyl-5-[1 -(3,4-diehlorophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl--[1 -( ,5-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[1 -(3,5-dichlorophenyl)-II I-pyrazol-4-yll-2H-tetrazole; 2-benzyl-5-[] -(2-bromophenyl)-1 R-pyrazol-4-ylj-2H-tetrazole; 1 -benzyl-5-[1 -(2-hroniophenyl)-I H-pyrazol-4-yI]-2T-I-tetrazo!e; 2-benzyl-5-[1 -(3-brornophenyl)-1 H-pyrazol-4-yl]-21-I-tetrazole; 2-benzyl-5-11 -(4-brornophenyl)-I II-pyrazol-4-yll -21 1-tetrazole; 1 -benzyl-5-[1 -(4-bromophenyl)-1H-pyrazol-4-yl]-21-1-tctrazolc; 2-benzyl-5-1l -(4-ifuorophenyl)-lII-pyrazol-4-ylI -211-tetrazole; 1 -benzyl-5-[ I -(4-fluoropheny[)-1 H-pyrazol-4-y!]-2H-tetrazole; 2-henzy!-5-[ I -(2-fluorophenyl)-I H-pyrazol-4-yl]-2H-tetrazolc; I -henzyl-5-[ I -(2-fluorophenyl)-1 II-pyrazol-4-yl]-21I-tetrazole; 2-benzyl-5-[1 -(2.3-dimethylphenyl)-1 H-pyrazol-4-yIj-21-I-tetrazole; 1-bcnzyl-5-[I -(2,3-dimethylphenyl)-I H-pyrazo]-4-yl]-2H-tetrazole; 2-henzyl-5-[1 -(2,4-dimethylphenyl)-1I1-pyrazol-4-yll-211-tetrazole; 1-benzy1-5-[1-(2.4-dirnethy1pheny1)-1H-pyraol-4-y1j-2H-tetrazole; 2-bcnzyl-5-[1 -(2,5-dimethylphenyl)-1 H-pyrazol-4-y!]-21-1-tetrazole; 1-benzyl-5-[1-(2,5-dimethylphenyl)-IH-pyrazol-4-yl]-2H-teftazole; 2-benzyl-5-[I -(2,6-dimethylphenyl)-1 fl-pyrazol-4-yI]-211-tetrazole; 1-benzyl-5-11-(2,6-dimethylphenyl)-1H-pvrazol-4-vlJ-2H-tetrazole; 2-benzyl-5-[1-(3,4-dimethylphenyl)-1I-I-pvrazol-4-yl]-2H-tetrazole; I -henzyl-5-[1 -(3,4-dirncthylphenvl)-1 H-pyrazol-4-ylI -2H-tetrazole; 2-benzyl-5-[1-(3,5-dimethylphenyl)-11I-pyTazol-4-yl]-2H-tetrazole; 1-benzyl-5-[1 -(3,5-diniethyiphenyl)-IR-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[1 -(2-ethyiphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-3-[1 -(2-ethylphenyl)-1 H-pyrazol-4-yI]-2H-tctrazole; 2-benzyl-5-[ I -(4-cthyphenyI)-I H-pyrazol-4-yll-21 1-tetrazole; I -benzyl-5-[1 -(4-ethylphenyl)-1 I-1-pyrazol-4-ylj-2H-tetrazole; S 2-benzyl-5-[1 -(4-methoxyphenyl)-I 1-T-pyrazol-4-yI]-211-tetrazole; I -benzyl-5-[I -(4-methoxyphenyl)-1iI-pyrazol-4-ylj-21-1-tetrazole; 2-benzyl-5-[1 -(2-rnethylphenyl)-1 H-pyrazol-4-ylj -2H-tetrazole; I -benzyl-5-[1 -(2-methylphenyl)-1Ii-pyrazol-4-yl]-2H-letrazole; 2-benzyl-5-[1 -(4-niethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazolc; 1 -benzyl-5-[ 1 -(4-methylphenyl)-I H-pyrazol-4-yfl-21 1-tetrazole; 2-benzy1-5-(-ch1oro-1-methy1-1iI-pyrazo1-4-yl)-2H-telrazo1e; 1 -benzyl-5-(5-ehloro-1-methyl-H-pyrazol-4-yI)-2H-tetrazole; 2-benzyl-5-(5-ehloro-1-ethyl-I H-pyrazol-4-yl)-2H-tetrazole; -bcnzyl-5-(5-ehloro-1-ethyl-1II-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-[5-ehloro-1-(2-methylpropyl)-1 H-pyrazol-4-yl]-2f1-tctrazole; 1-benzyl-5-[5-chloro-1 -(2-methylpropyl)-1H-pyrazol-4-yll-211-tetrazole; 2-benzyl-5-(1-bcnzyl-5-chloro-IH-pyrazol-4-yl)-211-tetrazole; 1-benzyl-5-(1-benzyl-5-chloro-1 H-pyrazol-4-yL)-2H-tetrazole; 2-benzyl-5-(5-ehloro-1-phenyl-lfl-pyrazol-4-yl)-2H-tetrazole; -benzyl-5-(5-chloro-1-phenyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-henzv1-5-5-eh1oro-1-(2-ch1oropheny1)-IH-pyrazol-4-yl]-21-1-tetrazole; 1-benzyl-5-[5-ehloro-l-(2-ehlorophenyl)-1I1-pyrazol-4-yl]-2H-tetra2ole; 2-benzyl-5-[5-ehloro-1-(3-cblorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5 -ehioro-1 -(3-ehiorophenyl)-I H-pyrazol-4-yfl-21I-tetrazole; 2-benzyl-545-ehloro-I -(4-ehlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; I -henzyl-5-[5-chloro-1-(4-ehlorophenyl)-1IHI-pyrazol-4-yI]-2H-tetrazo!e; 2-benzyl-5-[5-chloro-I-(2,3-diehlorophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; I -henzyl-5-[5-chloro-I-(2,3-dichlorophenyl)-IH-pyrazol-4-yIj-2H-tetrazole; 2-benzyl-5-[5-chloro-1-(2,4-dichlorophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[5-chloro-l -(2.4-dichlorophenyl)-IFI-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-ehloro-1-(2.5-dichlorophenyl)-1 i-I-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-545-ehloro-1-(2,5-diehlorophenyl)-I FI-pyrazol-4-yll-21I-tetrazole; 2-benzyl-5-[5-ehloro-1-(2,6 -dichlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; I -benzyl-5-[5-chloro-1-(2,6 -diehlorophenyl)-1H-pyrazol-4-yI}-21-T-tetrazole; 2-benzyl-5-[5-chloro-I-(3,4-diehJorophenyl)-1I-1-pyrazol-4-yl] -2H-tetrazole; I -bcnzyl-5-[5-chloro-1-(3,4-dichlorophenyfl-I FT-pyrazol-4-yl]-2H-tctrazole; 2-benzyl-5-{5-chloro-1 -(3,5-dichlorophenyl)-1H-pyrazol-4-yl]-21i1-tetrazole; -benzy!-5-[5-ehloro-1-(3,5-dichlorophenyl)-1H-pyrazol-4-yl] -21-f-tetrazolc; 2-benzyl-5-1 1 -(2-bromopbenyl)-5 -chioro-I H-pyrazol-4-yl] -2H-tetrazole; 1 -benzyl-5-[1 -(2-brornophenyl)-5-chioro-1 H-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[1-(3-bromophenyl)-5-chloro-1H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[1 -(3-brornophenyl)-5-chloro-I 1-1-pyrazol-4-yl]-2H-tetrazole; 2-benzy1-5-1 -(4-bromopheny!)-5-chloro-11 I-pyrazol-4-yl] -2H-tetrazole; 1 -benzyl-5-[1 -(4-brornophenyl)-5-chloro-1 H-pyrazol-4-yli-21I-tetrazole; 2-benzyl-5-[5-chloro-1-(4-tluorophenyl)-I fl-pyrazo1-4-y1]-2H-terazo1e; I -benzyl-5-[5-chloro-1 -(4-fluorophenyl)-IH-pyrazol-4-ylj-2H-tctrazole; 2-bcnzyl-5-[5-chloro-1 -(2-fluorophenyl)-1H-pyrazo!-4-yfl-21-1-tetrazole; 1-benzy1-5-5-chloro-l -(2-fluorophcnyl)-1II-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-chloro-1-(2,3-dimethylphenyl)-1II-pyrazol-4-yl] -2H-tetrazole; 1-benzyl-5-[5-chloro-1-(2,3-dimethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-chloro-1-(2,4-dimethylphenyl)-IIi-pyrazol-4-yl] -211-tetrazole; 1 -benzyl-5-[5-chloro-I -(2,4-dimethylphenyl)-1 H-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[5-chioro-1 -(2, 5-dirnethylphenyl)-I H-pyrazol-4-yl] -211-tetrazole; 1 -benzyl-5-[5-chloro-1 -(2,5-dirnethypheny1)-I T-I-pyrazol-4-ylj-2H-tetrazo!e; 2-benzyl-5-[5-chloro-i -(2,6-dimethylphenyl)-1II-pyrazol-4-yl]-2N-tetrazole; 1 -benzy!-5-[5-chloro-1-(2,6-dimeLhylphenyl)-1H-pyrazol-4-yl] -21-1-tetrazole; 2-benzyl±5-[5-chloro-1-(3,4-dirnetliylphenyl)-I f-1-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[5-chloro-1 -(3,4-dimethylphenyl)-1H-pyrazol-4-ylj-2H-tetrazole; 2-bcnzyl-5-[5-chloro-1-(3,5-dirnethylphenyl)-JR-pyrazol-4-yI] -2H-tetrazole; 1-bcnzyl-5-[5-chloro-I-(3,5-dimcthylphenyl)-I I1-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-chloro-I -(2-ethylphcnyl)-1 I-1-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[5-chloro-1-(2-elfylphenyl)-I H-pyrazol-4-yl]-211-tctrazole; 2-benzyl-5-[5-chloro-1 -(4-ethylphcnyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -henzyl-5-[5-chloro-1-(4-ethylphenyl)-1H-pyrazol-4-ylj-2H-tctrazole; 2-benzyl-5-[5 -cliloro-1 -(4-rnethoxyphenyl)-I FI-pyrazol-4-yl] -21 1-tetrazole; 1-benzyl-5-[5 -chloro-1 -(4-methoxyphenyl)-1I-I-pyrazol-4-ylJ-2H-tetrazolc; 2-benzyl-5-[5-chloro-I -(2-methyiphenyl)-] H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5-chloro-1-(2-methylphcnyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzy1-5-5-ch1oro-1 -(4-methylphenyl)-1 H-pyrazol-4-yl]-2ll4etrazole; I -benzyl-5-[5-chloro-1-(4-methylphenyl)-IH-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-(5-hromo-l -methyl-If1-pyrazol-4-yl)-21-I-tetrazole; I-hcnzyl-5-(5-broino-1-methyl-IH-pyrazol-4-yl)-211-telxazole; 2-benzyl-5-(5-broino-1-ethyl-I H-pyrazol-4-yI)-2H-tetrazole; -benzyl-5-(5-bromo-I -ethyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-[5-bromo-1-(2-methylpropyl}11-I-pyrazol-4-yl]-2H-tetrazole; -henzyl-545-bromo-1 -(2-methylpropyl)-1 H-pyrazol-4-yl]-21-I-tetrazole; 2-henzyl-5-(l-benzyl-5-bromo-1I-I-pyrazol-4-yI)-2H-tetrazole; 1 -benzyl-5-(1-benzyh5-bromo-1H-pyrazol-4-yl)-2T-T-tetrazole; 2-benzyl -5 -(5-bromo-I -phenyl-11 1-pyrazol-4-yl)-2H-tetrazole; 1-benzyl-5-(5-bromo-1-phenyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-[5-bronio-1-(2-chlorophcnyl)-1 H-pyrazol-4-yll-211-tetrazole; I -benzyl-5-[5-bromo-1-(2-chlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-bromo-1-(3-chlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[5-bromo-I -(3-ehlorophenyl)-1IJ-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-bromo-I -(4-ehlorophcnyl)-1I-I-pyrazol-4-yl]-21-1-tetrazole; 1 -bcnzyl-5-[5 -bromo-1 -(4-chlorophenyl)-I H-pyrazol-4-yl]-2H-tetrazolc; 2-benzyl-5-[5-bronio-1 -(2,3-dich1orophcny1)-1H-pyrazo1-4-y1-2I-I-tetrazole; 1.-henzyl-5-[5-bromo-I-(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazolc; 2-benzyl-5-[5-bromo-1 -(2,4-dichiorophenyl)-I H -pyrazo I-4-yl] -2H-tetrazole; 1-bellzyl-5-[5-bromo-I -(2,4-dichlorophcnyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-bromo-I -(2,5-dichlorophenyl)-1II-pyrazol-4-ylj-2H-tetrazole; I -benzy1-5-5-bromo-1-(2,5-dich1oropheny1)-1H-pyrazo1-4-yl]-2T-I-tetrazo1e; 2-benzyl-5-[5-brorno-1-(2,6-dichlorophenyl)-I H-pyrazol-4-yl]-21-I-tetrazole; 1 -bcnzy I-5-[5-hromo-1-(2,6-diclilorophenyl)-1H-pyrazol-4-ylj-2H-tctrazole; 2-benzy1-5-[5-brorno-1-(3,4-dich1orophcny-1 H-pyrazol-4-yI]-211-tetrazole; 1-benzyl-5-5-bronio-I -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-21-1-tetrazole; 2-bcnzyl-5-[5-bromo-1-(3,5-dichlorophcnyl)-I H-pyrazol-4-y!]-211-tetrazole; 1-benzyl-5-[5-bromo-I -(3,5-dichlorophcnyl)-1II-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-hrorno-1-(2-brornophenyl)-1I1-pyra.zol-4-ylj-2H-tetrazole; 1 -benzyl-5-{5-bromo-1-(2-bromophenyl)-l H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5 -brorno-I -(3-brornophenyl)-1 H-pyrazol-4-yll-21 I4etrazole; 1-hcnzyl-5-[5-bromo-1-(3-bromophenyl)-IH-pyrazol-4-yI]-21-I-tetrazole; 2-benzyl-5-[5-bromo-I -(4-hrornophenyl)-1 H-pyrazol-4-yfl-2H-tetrazole; 1 -bcnzyl-5-[5-bromo-1-(4-bromophenyl)-1H-pyrazol-4-yll-211-ietrazole; 2-benzyl-5-[5-bromo-1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; I -benzyl-5-[5 -brorno-I -(4-fluorophenyl)-1 H-pyrazol-4-yl] -21-1-tetrazole; 2-hcnzyl-5-{5-hromo-1-(2-fluorophenyl)-1II-pyrazol-4-yl]-2F1-tetrazole; 1 -benzyl-5-[5-brorno-1-(2-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazoie; 2-benzyl-5-[5-brorno-1 -(2.3-diehlorophenyl)-I H-pyrazol-4-yI]-21 1-tetrazole; 1 -benzyl-5-[5-brorno-1 -(2,3-diehiorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-brorno-1-(2,4-diehlorophcnyl)-1 H-pyrazol-4-yI]-2H-tetrazole; -henzyl-3-[5-bromo-1-(2,4-dichlorophenyl)-1H-pyrazol-4-ylj-21-1-tetrazole; 2-benzyl-5-[5-bromo-1 -(2,5-dichlorophenyl)-1 H-pyrazo1-4-yI-2H-tetrazole; 1 -henzvl-5-[5-hromo-1-(2,5-dichlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 2-benzvl-5-[5-bromo-1-(2,6-dichlorophenyl).-1H-pyrazol-4-ylj-2H-tetrazole; 1-benzyl-545-bromo-1 -(2,6-dichlorophenyl)-I 1-T-pyrazo1-4-y1-2II-tetrazo1e; 2-benzyl-5-[5-brorno-l -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2H-ietrazole; I -bcnzyl-5-[5-bromo-1-(3.4-diehloroplienyl)-1II-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[5-bromo-1 -(3,5-diehiorophenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 1 -henzyl-5-[5-bronio-1-(3,5-diehloroplienyl)-1II-pyrazol-4-yI] -2F1-tetrazole; 2-benzyl-5-[5-bromo-1-(2-ethylphenyl)-1H-pyrazol-4-yI]-2H-tetrazolc; 1-benzyl-5-[5-bromo-1 -(2-ethylphenyl)-1 H-pyrazol-4-yIJ-211-tetrazole; 2-benzyl-5-[5-bromo-1-(4-ethylphenyl)-1 H-pyrazol-4-yl]-211-tetrazole; 1-benzv1-5-[5-hromo-I-(4-ethy1pheny1)-1H-pvrazo1-4-y1-2H-tetrazo1e; 2-henzyl-5-[5-bromo-1 -(4-methoxyphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5Thromo-I -(4-niethoxypheny-1II-pyrazo1-4-y1]-2H-teErazo1e; 2-benzyl-5-[5-hromo-1 -(2-methylphenyl)-1H-pyrazol-4-yl]-2H-tctrazole; 1-benzyl-5-[5-bromo-1-(2-methylphenyl)-1 H-pyrazol-4-yIj-21-I-tetrazole; 2-benzyl-5-[5-bronio-I -(4-methylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5-brorno-1-(4-rnethyIpheny-1 T-T-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-(5-iodo-1-methyl-I H-pyrazol-4-yl)-2H-tetrazole; 1 -benzyl-5-(5-iodo-1 -methyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-(.1-ethyl-5-iodo-1H-pyrazol-4-yI)-2H-tetrazole; 1 -benzyl-5-( I -ethy!-5-iodo-1 I-1-pyrazol-4-yl)-21 1-tetrazole; 2-benzyl-5-[5-iodo-I -(2-methylpropyl)-IH-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5 -iodo-I -(2-methyipropyl)-1 fI-pyrazol-4-yl]-211-tetrazole; 2-benzy1-5-(1-benzy1-5-iodo-1ILpyrazoL4-y)-2H-tetrazo[e; 1 -benzyl-5-( 1 -benzyl-5-iodo-I H-pyrazol-4-y!)-2H4etrazole; 2-henzyl-5-(5-iodo-1-phenyl-1H-pyrazol-4-yl)-211-tetrazole; 1 -benzyI-5-(5-iodo-1-pheny1-1H-pyrazo-4-y1)-2H-tetrazo1e; 2-berizyl-5-[1 -(2-chlorophenyl)-5-iodo-1H-pyrazol-4-yll-21I-tetrazole; 1-benzyl-5-[1 -(2-ch1oropheny)-5-iodo-1II-pyrazo1-4-y1j-2H-1etrazoe; 2-henzy1-5-[1-(3-ch1oropheny1)-5-iodo-1Hpyrazo1-4-y1]-2H-tctraz&e; -hcnzyl-5-[I -(3-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tefrazole; 2-benzyl-5-[1-(4-chlorophenyl)-5-iodo-1H-pyrazoi-4-yl]-211-tetrazole; 1-benzyl-5-j) -(4-chlorophenyl)-5-iodo-1 II-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[1 -(2,3-dichlorophenyl)-5-iodo-1H-pyrazol-4-ylj-2H-tctrazolc; 1-benzy15-[1 -(2,3-dichlorophcnyl)-5-iodo-lfT-pyrazoL-4-yl]-2H-tetrazole; 2-bcnzyl-5-[1 -(2,4-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-{1-(2,4-dichlorophenyl)-5-iodo-1}{-pyrazoT-4-yI] -21-1-tetrazo!e; 2-benzyl-5-[1-(2,5-dichlorophenyl)-5-iodo-1 I-1-pyrazot-4-yl]-211-tctrazolc; 1-benzyl-5-[1 -(2,5-dich1orophenyl)-5-iodo-1H-pyrazo1-4-y1-2II-tetrazo1e; 2-benzy!-5-[1-(2,6-dichlorophenyl)-5-iodo-1II-pyrazol-4-ylj-2H-tetrazole; 1-benzyl-5-[1-(2.6-dichlorophcnyl)-5-iodo-1H-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[1 -(3,4-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tetrazole; 1-bcnzy-5-[I (3,4-dich1oropheny1)-5-iodo-I H-pyrazol-4-y!]-2H-tctrazole; 2-benzyl-5-[1-(3,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yfl-214-tetrazole; 1-benzyl-5-[1-(3,5-dielilorophenyl)-5-iodo-1II-pyrazol-4-ylj-2H-tetrazole; 2-bcnzyl-5-[1 -(2-bromophenyl)-5-iodo-1H-pyrazol-4-ylJ-2H-tetrazole; 1 -benzyl-5 -[1 -(2-brornophenyl)-5 -iodo-1 H -pyrazo l-4-y!-2I 1-tetrazole; 2-benzy1-5-1 -(3-bromophenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tetrazole; 1 -benzv1-5-11-(3-bromopheny1)-5--iodo1H-pvrazo1-4-yl]-2H-tetrazo1e; 2-benzyl.5-[1-(4-bronophenyl)-5-iodo-1 i-I-pyrazol-4-yl]-211-tetrazole; I -benzy1-5-1 -(4-bromophenyl)-5-iodo-11-I-pyrazol-4-yl]-2T-T-tetmzole; 2-bcnzyl-5-[1-(4-fluorophenyl)-5-iodo-1 H-pyrazoI-4-yl-2H-tetrazo1e; 1-benzyl-5-[1-(4-Iluorophenyl)-5-iodo-1H-pyrazol-4-yll-211-tetrazole; 2-benzyl-5-[1-(2-fluorophenyl)-5-iodo-1M-pyrazol-4-ylj-2H-tetrazo!e; 1 -benzyl-5-[1 -(2-fluorophenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[1 -(2,3-dimethylphcnyl)-5-iodo-1H-pyrazol-4-yli-21-I-tetrazole; 1-benzyl-5-[1-(2,3-dimethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[1 -(2,4-dimethylphenyl)-5-iodo-1FI-pyrazol-4-ylj-2H-tetrazole; I -benzyl-5-[1 -(2,4-dimethylphenyl)-5-iodo-1II-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[1 -(2,5-dirneihylphenyl)-5-iodo-1H-pyrazol-4-yI]-2H-tetrazole; 1-benzyl-5-[1 -(2.5-dinicthylphenyl)-5-iodo-lT-J-pyrazol-4-yl]-21I-tetrazole; S 2-henzyl-5-[1 -(26-dimethy1pIieny1)-5-iodo-1H-pyrazo1-4-y1]-2H-tetrazoIc; 1-benzyl-5-{1-(2.6-dimethylphenyl)-5-iodo-1H-pyrazol-4-yI]-2H-tetrazole; 2benzyi-5-[l -(3,4-dimethylphenyl)-5-iodo-lII-pyrazol-4-yl]-21-I-tetrazole; 1-benzyl-5-[1-(3,4-dirnethylphenyi)-5-iodo-l l-l-pyrazol-4-yll-211-tetrazole; 2-benzyl-5-[I -(3,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-ylj-2H-tetrazole; 1-benzyl-5-[1-(3,5-dirnethylphenyl)-5-iodo-l-T-pyrazo!-4-yl] -211-tetrazole; 2-benzyl-5-[1-(2-ethylphenyl)-5-iodo-l H-pyrazol-4-yll-21-I-tetrazole; I -beiizyl-5-[1 -(2-ethylphenyl)-5-iodo-1II-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[i-(4-ethylphenyl)-5-iodo-H-pyrazol-4-ylj-2H-tetrazole; 1-benzyl-5-[I -(4-ethylphenyl)-5-iodo-1H-pyrazol-4-yl]-21T-wtrazole; 2-henzyl-5-[5-iodo-l -(4-methoxyphenyl)-1I1-pyrazol-4-ylj-2H-teirazole; I -henzyl-5-{5-iodo-1 -(4-methoxyphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-iodo-1 -(2-methylphenyl)-1H-pyrazol-4-y]]-21-I-tetrazole; 1-benzyl-5-[5-iodo-I -(2-methyiphenyl)-IH-pvrazol-4-yij-2H-tetrazole; 2-benzy!-5-[5-iodo-1-(4-methylphenyl)-1H-pyTazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5-iodo-1 -(4-methyiphenyl)-I 1-1-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzyl)-5-(1-methyl-1II-pyrazol-4-yl)-2H-tetrazole; 1 -(4-bromobenzyl)-5 -(1-methyl-i H-pyrazol-4-yI)-21-i-tetrazole; 2-(4-bromobenzyl)-5-( I -ethyl-I fl-pyrazol-4-yl)-21-1-tetrazole; 1-(4-bromohenzyl)-5-(1-cthyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-(4-bromobenzyl)-5-{1 -(2-methylpropyl)-I H-pyrazol-4-yI]-211-tetrazole; 1-(4-bromohenzyl)-5-[1 -(2-rnethylpropyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-U -benzy!-I 1-t-pyrazol-4-yl)-2-(4-bromobenzyl)-2H-tetrazole; 5-( I -benzyl-1 ll-pyrazol-4-yI)-1 -(4-brornobenzyl)-2H-tetrazole; 2-(4-brornohenzyl')-5-(1-phenyl-IH-pyrazol-4-yl)-2H-teirazole; 1-(4-hromohenzyl)-5-(1-phenyl-1H-pyrazol-4-yl)-2H-tetrazole; 2-(4-hromobenzyl)-5-[1 -(2-chlorophenyl)-I H-pyrazol-4-yll-211-tetrazole; 1 -(4-bromobenzyl)-5-[T -(2-chiorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1-fl -chiorophenyl)-1 H-pyrazol -4-ylJ-2H-tetrazole; 1-(4-brornobenzyl)-5-[I -(3-chlorophenyl)-1 H-pyrazoi-4-yl]-2H-tetrazole; 2-(4-brornobcnzyl)-5 -[1 -(4-ch1oropheny)-I F1-pyrazol-4-yl]-21-I-tetrazole; 1-(4-bromobenzyl)-5-[1 -(4-chlorophenyl)-1H-pyrazol-4-yll-2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2.3-dichiorophenyl)-1 H-pyrazo!-3-yl]-21-1-tetrazole; 1-(4-bromobenzy1)-5-1-(2,3-dich1orophenyI)-1H-pyrazo1-3-y1]-2II-tetrazo1e; 2-(4-bromobenzyl)-5-[1 -(2,4-dichlorophenyl)-1IT-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyl)-5-[1 -(2,4-dichloropheny1)-1H-pyrazo-4-y1]-2H-tctrazo1e; 2-(4-bromobenzyl)-5-[ 1 -(2,5-dichlorophenyl)-1 1-T-pyrazol-4-yll -211-tetrazole; 1 -(4-brornobenzyl)-5-[1 -(2,5-dichiorophenyl)-1M-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2,6-dichlorophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bronobenzyl)-5-[1 -(2,6-dich]orophenyl)-1H-pyra2ol-4-ylj-2H-tctrazole; 2-(4-brornobcnzy!)-5-[1-(3,4-dichlorophenyl)-1H-pyrazol-4-yI] -21-1-tetrazole; 1-(4-bromobenzyl)-5-[1 -(3,4-dichlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[l -(3,5-dich1oropheny1)-1H-pyrazo1-4y1j-2H-tetrazo1e; -(4-bromobenzyl)-5 -[1 -(3,5-dichlorophenyl)-I H -pyrazol-4-yll-21-1-tetrazole; 2-(4-brornobenzyl)-5-[1-(2-bromophenyl)-1 H-pyrazol-4-yl]-2H-tetrarzole; 1 -(4-bronobenzyl)-5-[1 -(2-hrornophcnyl)-1 H-pyrazol-4-ylj-21-1-tetrazole; 2-(4-bromobenzyl)-5-[1-(3-bromophcnyl)-1H-pyraz&-4-yIj-2H-tetrazolc; 1-(4-brornobenzyl)-5-[1 -(3-bromophenyl)-IH-pyrazol-4-yll-211-tetrazole; 2-(4-bromobenzyl)-5-[1 -(4-hromophenyl)-1II-pyrazol-4-yi]-2H-tetrazole; 1 -(4-bromobenzyl)-5 -[1 -(4-bromophenyl)-I H-pyrazol -4-yl]-2H-tetrazole; 2-(4-bromohenzyl)-5 -[1 -(4-thiorophenyl)-1 T-T-pyrazol-4-yll -21 1-tetrazole; 1 -(4-brornobenzy1)-5-1 -(4-fiuorophenyl)-1I-I-pyrazol-4-ylj-2H-tetrazolc; 2-(4-brornobenzyl)-5 -[1 -(2-fluorophenyl)-I 1-1-pyrazol -4-yl] -2 1-1-tetrazole; I -(4-hromohenzyl)-5-[1-(2-fluorophenyl)-H-pyrazol-4-yl]-2H-tetrazole; 2_(4-bromobeniy1)-5-1-(2,3-dimethy1pheny1)-1H-pyrazo1-4-y1j-2H-tetrazoIe; 1-(4-bromohcnzyl)-5-[1-(2,3-dirnethylphenyl) -1H-pyrazol-4-yIl-211-tetrazole; 2-(4-bromobcnzyl)-5-[1 -(2,4-dimethylphcnyl)-I 1-T-pyrazol-4-yl]-2H-telrazole; 1-(4-brornobenzyl)-5-[ 1 -(2,4-dimethylphcnyl)-1H-pyrazol-4-ylj-2H-tctrazo!e; 2-(4-bromohenzyl)-5-[1 -(2,5-dimethylphenyl)-I H-pyrazol-4-yl]-2H-telrazole; 1_(4-broinobenzyl)-5-[1-(2,5-dirnethylphcnyl) -1FI-pyrazol-4-ylj-2F1-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2,6-dimethylphenyl)-1H-pyrazol-4-yI]-2H-tctrazole; I -(4-hrornobcnzv1)-5-[1-(2.6-dimethypheny!)-1H-p)Tazo1-4-y11-2II-tetrazo1e; 2-(4-bromobenzyl)-5-[1 -(3,4-dirncthylphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyl)-5 -[1 -(3,4-dimethyipheny 0-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1 -(3,5-dimethylphcnyl)-IH-pyrazol-4-yl]-2H-tetrazole; I -(4-hromobenzyl)-5-[1 -(3,5-dimethylphenyl)-1II-pyrazol-4-yl]-21-1-tetrazo!e; 2-(4-bromobenzyl)-5-[1 -(2-ethylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-bromoberizyl)-5-[1 -(2-ethylplienyl)-1H-pyrazol-4-yfl-2H-tetrazole; S 2-(4-bromobenzyl)-5-[1 -(4-ethyiphenyl)-I H-pyrazol-4-yl]-2H-tctrazole; I -(4-bromobenzyl)-5 -H -(4-ethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzy-5-[1 -(4-methoxyphenyl)-IH-pyrazol-4-yI]-2F1-tetrazole; 1 -(4-brornobenzyl)-5-[1 -(4-rnethoxyphcnyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[ I -(2-methyiphenyl)-1I-I-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyl)-5-[1 -(2-methyiphenyl)-1 H-pyrazol-4-yI]-211-tetrazole; 2-(4-bromobenzy1)-5-j -(4-methylphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; I -( -bromobenzyl)-5-[1 -(4-methylphenyl)-1H-pyrazol-4-yl]-21-1-tetrazole; 2-(4-bromobenzy1)-5(5-ehloro-1-methyl-I H-pyrazol-4-yl)-211-tetrazole; 1-(4-bromobenzyl)-5-(5-chloro-l -methyl-lliI-pyrazol-4-yl)-2H-1etrazole; 2-(4-bromobenzy!)-5-(5-chloro-1-ethyl-1H-pyrazol-4-yl)-2H-tetrazolc; I -(4-brornobcnzyl)-5-(5-ehloro-1 -ethyl-I H-pyrazol-4-yl)-211-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-1 -(2-rnethylpropyl)-1H-pyrazol-4-yl]-21-I-tetrazole; 1 -(4-bromobenzyl)-5-[5-chloro-l -(2-methylpropyl)-1 H-pyrazol-4-yl]-2H-tctrazole; 5-(1-benzyl-5-chloro-1M-pyrazol-4-yI)-2-(4-bromobenzyl)-21{-tetrazole; 5-(1-benzyl-5-chloro-1H-pyrazol-4-yl)-1-(4-bromobenzyl)-2H-tetrazole; 2-(4-brornobenzyl)-5-(5-ehloro-1-phenyl-lIi-pyrazol-4-yl)-2H-tctrazole; I -(4-hromobenzyl)-5-(5-chloro-1-phenyl-I T-1-pyrazol-4-yl)-211-tetrazole; 2-(4-brornobenzy1)-S-3-ehIoro-I -(2-chlorophenyl)-1H-pyrazol-4-yl]-2H-tctrazole; 1-(4-bromobenzyl)-5-[3-chloro-l -(2-ehlorophenyl)-I H-pyrazol-4-yIl-211-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-1-(3-ehlorophenyl)-lII-pyrazol-4-yl] -2H-tetrazole; 1_(4-brornobenzyl)-5-[5-chloro-1-(3-ehlorophenyl)-1H-pyrazol-4-yI] -2fl-tetrazole; 2-(4-brornobenzyl)-5-[5-chloro-l-(4-chlorophenyl) -1H-pyrazol-4-yll-211-tetrazole; 1-(4-hromobenzyl)-5-[5-chloro-l -(4-ehloropheny!)-1 Ii-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-1-(2,3-dichlorophenyl)-l H-pyrazol-4-yI]-211-tetrazole; 1 _(4-hrornobcnzyl)-5-[5-chloro-1-(2,3-dichlorophenyl) -1H-pyrazol-4-yll-2F1-tetrazole; 2-(4-bromobenzyl)-5j5-ehlovo-I -(2,4-diehlorophenyl)-1II-pyrazol-4-yI]-2H4etrazole; 1-(4-bromobenzyl)-5-[5-chloro-1 -(2,4-dichiorophenyl)-I H-pyrazol-4-yl]-21-I-teirazole; 2-(4-hrornobenzyl)-5-[5-chloro-i-(2,5-dichlorophdnyl) -1H-pyrazol-4-yli-2H-tetrazolc; 1 -(4-bromoberizyl)-5-[5-chloro-1 -(2,5-dichiorophenyl)-I H-pyrazol-4-ylI-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-1-(2,6-dichlorophenyl)-1II-pyrazol-4-yl] -2H-tetrazde; 1 -(4-brornobenzy1)-5-5-ch1oro-1 -(2,6-dichlorophenyl)-11-1-pyrazol-4-yl]-2H-tetrazolc; 2-(4-hrornobcnzyl)-5-[5-chloro-1 -(3,4-dichlorophenyl)-1I-1-pyrazol-4-yll-211-tetrazole; 1 -(4-bromobenzyl)-5-[5-ehloro-1-(3,4-diehlorophenyl)-11-1-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzy1)-5-5-chIoro-1 -(3.5-dichiorophenyl)-1 I-I-pyrazol-4-yI]-2H-tetrazole; I -(4-bromobenzyl)-5-[5-chloro-1 -(3,5-dich!orophenyl)-1II-pyrazol-4-yl]-211-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2-bromophenyl)-5-chloro-IH-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyl)-5-[1 -(2-brornophenyl)-5-chloro-IH-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(3-brornophenyl)-5-chloro-IH-pyrazol-4-yl]-2H-tctrazole; 1 -(4-bromohenzyl)-5 -[1 -@ -hromophcnyl)-5-chloro-11 I-pyrazol-4-yl] -21-1-tetrazole; 2-(4-brornobenzyl)-5-[1 -(4-brornophenyl)-5-chloro-1II-pyrazol-4-yl]-2H-tetrazole; I -(4-bromobenzyl)-5-[1 -(4-brornopheny1)-5-ch1oro-1H-pyrazo1-4-y1-2H-tctrazo1e; 2-(4-bromobenzyl)-5-[5-chloro-1-(4-fluorophenyl) -1H-pyrazol-4-yli-21-I-tetrazole; 1-(4-broinobenzyl)-5-[5-chloro-1-(4-fluorophenyl)-IH-pyrazol-4-yl] -2H-tetrazole; is 2-(4-bromobenzyl)-5-[5-chloro-1-(2-tluorophenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 1-(4-brornobenzyl)-5-[5-chloro-1 -(2-fluorophcnyl)-1 H-pyrazol-4-yIl-21-I-tetrazole; 2-(4-brornohenzyl)-5-[5-chloro-1-(2,3-dimethylphenyl) -IH-pyrazol-4-ylj-21-1-tetrazole; 1-(4-brornobenzyl)-5-[5-ehioro-1 -(2,3-dimethylphenyl)-11-I-pyrazol-4-yl]-21-1-tetrazole; 2-(-brornobenzyl)-5-[5-ehIoro-I -(2,4-dimethylphenyl)-1I-1-pyrazol-4-yl]-2H-telrazole; 1 -(4-hroniobenzyl)-5-[5-ehloro-1-(2,4-dimethylphenyl) -IH-pyrazol-4-ylI-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-ehloro-1 -(2,5-dimethy1phcny-I H-pyrazol-4-yI]-211-tetrazole; 1-(4-brornobenzyl)-5-[5-ehloro-I -(2,5-dimethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromohenzyl)-5-j7-chloro-1-(2.6-dimethylplienyl) -1H-pyrazol-4-ylj-2H-tetrazole; 1 -(4-bromobenzyl)-5-[5-chloro-I -(2,6-dimethylphenyl)-1 I1-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-chloro-1 -(3,4-dimethyiphenyl)-1I-I-pyrazol-4-yl]-21-I-tetrazole; I -( -hromobenzyl)-5-[5-ehloro-1 -(3,4-dimethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-{5-cliloro-1-(3,5-dimetfylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; I -(4-hrornobenzyl)-5-[5-chloro-1 -(3,5-dimethyiphenyl)-1I-i-pyrazol-4-yT]-21-1-tetrazole; 2-(4-hromohenzy1)-5-5-ch1oro-1-(2-ethv1phenyI)-I H-pyrazol-4-ylJ-2H-tetrazole; 1-(4-bromobenzyl)-5-[5-ehloro-I -(2-ethylphenyl)-I I-1-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-ehloro-1-(4-ethylphenyl)-11-1-pyrazol-4-yl] -2H-tetrazoic; I -(4-bromobenzyl)-5-[5-ehloro-1 -(4-ethylphcny])-I H-pyrazol-4-yl]-211-tetrazole; 2-(4-bromobenzyl)-S-[5-ehloro-I -(4-methoxyphenyl)-1FI-pyTazol-4-yl]-2H-telrazole; I -( -bromobenzyl)-3-[5-chloro-1-(4-methoxyphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-chloro-1-(2-rnethylphenyl)-ifI-pyrazol-4-yl] -2H-tetrazole; -(4-brornohenzyl)-5-[5-ch[oro-1 -(2-rnethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-1-(4-methylphenyl)-lII-pyrazol-4-yl] -2F1-tetrazole; -(4-bromobenzy])-5-[5-chloro-1 -(4-rnetliy]phenyi)-1 H-pyrazoI-4-yI]-2H-tetrazoe; 2-(4-bromobenzyl)-5 -(5-bromo-1-methyl-i H-pyrazol-4-yi)-2H-tctrazolc; 1 -(4-bromohenzyl)-5-(5-brorno-1-methyl-I IJ-pyrazol-4-yl)-211-tetrazole; 2-(4-bromobenzyl)-5-(5-brorno-1-ethyl-1H-pyrazol-4-yl)-2H-tetrazole; 1 -(4-bromobenzyl)-5-(5-bromo-1 -ethyl-IH-pyrazol-4-yl)-2H-tetrazole; 2-(4-brornobenzy)-5-[5-bromo-1 -(2-methypropy1)-l H-pyrazol-4-yI]-2H-tetrazo[e; 1 -(4-brornobenzyl)-5-[5-bromo-1-(2-methylpropyl)-1H-pyrazol-4-yl] -2H-tetrazole; 5-(1-benzyl-5-brorno-1H-pyrazol-4-yl)-2-(4-brornobenzyl)-2H-tetrazole; -0 -benzyl-5-bromo-1 H-pyrazol-4-yl)-I -(4-hrnmobenzyl)-211-tetrazole; 2-(4-bromobenzyl)-5-(5-bromo-1 -phenyl-11 I-pyrazol-4-yl)-21-1-tetrazole; 1 -(4-bromobenzyl)-5-(5-brorno-1 -phenyl-1 H-pyrazol-4-yl)-2}-1-tetrazoie; 2-(4-bromobenzyl)-5-[5-brorno-I -(2-ehlorophenyl)-I H-pyrazol-4-yI]-2R-tetrazole; 1 -(4-bromobcnzyl)-5-[5-brorno-l -(2-ehlorophenyl)-1H-pyrazol-4-yll-211-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-I -(3-chlorophenyl)-1H-pyrazol-4-ylj-21-i-tetrazole; 1 -(4-bromobenzyl)-5-[5-bromo-1 -(3-chlorophcnyl)-IM-pyrazoi-4-yl]-21-1-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-i-(4-chlorophenyl)-i I1-pyrazol-4-yll-21-I-tetrazole; 1 -(4-bromobenzyl)-5-[5-bromo-i-(4-chiorophenyl)-l H-pyrazol-4-y!]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-brorno-1-(2,3-dichlorophenyl)-i l-1-pyrazol-4-yI]-21-T-tetrazole; I -(4-bromohenzy1)-5-5-bromo-1-(2,3-dich1orophenyl) -1ll-pyrazol-4-y1j-2H-teftazo1e; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2,4-dichlorophenyl)-1H-pyrazol-4-ylJ-2H-tetrazole; l-(4-brornobenzyl)-5-[5-brorno--(2,4-diehlorophenyl)-1 H-pyrazol-4-ylI-211-tetrazoie; 2-(4-hromohenzyl)-5-[5-hromo-1-(2,5-dichlorophenyl)-1H-pyrazol-4-yl] -2H-tetrazole; 1 -(4-bromobenzyl)-5-[5-brorno-1-(2,5-diehlorophenyl) -1H-pyrazol-4-ylj-2H-tetrazo]e; 2-(4-bromobenzy1)-5-5-bromo-1 -(2,6-diehiorophenyl)-I U-pyrazo[-4-yI]-21T-tetrazo!e; 1-(4-bromobenzyl)-5-[5-bromo-i-(2,6-diehlorophenyl)-1H-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1-(3,4-diehlorophenyl)-I I-{-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyl)-5-[5-hrorno-1 -(3,4-diehlorophenyl)-1H-pyrazol-4-yl]-21-I-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1 -(3.5-diehlorophenyl)-1iI-pyrazol-4-yl]-2H-teirazole; i-(4-bromobenzyl)-545-brorno-I -(3,5-diehlorophenyl)-I H-pyrazol-4-yl]-21-1-tetrazole; 2-(4-hrornobenzyl)-5 -[5-brorno-1 -(2-bromophenyl)-1 H-pyrazol-4-yll -21 1-tetrazole; 1-(4-bromobenzyl)-5-[5-bronio-I -(2-brornophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1-(3-broniophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobenzyl)-5-[5-hrorno-1-(3-brornophcnyl)-1H-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzy)-5-[5-brorno-1-(4-brornopheny1)-I H-pyrazol-4-yl}-2H-tctrazole; 1 -(4-brornobenzyl)-5-[5-bromo-I -(4-bromophenyl)-1 H-pyrazo1-4-y1-2II-tetrazo1e; 2-(4-bromobenzyl)-5-[5-brorno-1 -(4-fluorophenyfl-1II-pyrazol-4-ylj-2H-teftazole; I-(4-bromobenzyl)-5-[5-hromo-1-(4-fluorophenyl)-IH-pyrazol-4-yl] -2H-tctrazolc; 2-(4-bromobenzyl)-5-[5-bromo-1-(2-fluorophcnyl)-1 H-pyrazol-4-yfl-21-I-tetrazole; 1 -(4-brornobenzyl)-5-[5-brorno-1 -(2-fluorophenyl)-I H-pyrazol-4-yl]-211-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2,3-dimethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; -(4-hromobenzyl)-5-[5-bromo-1-(2,3-dimethylphenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 2-(4-bromobenzy1)-5-[5-brorno-4-(2,4-diniethyIphenyI)-11T-pyrazo1-4y1] -2H-tetrazo1e; 1-(4-bromobenzyl)-5-[5-hromo-I-(2,4-dimethylphenyl)-1H-pyrazok4-yI] -2H-tetrazole; 2-(4-hromohenzyl)-5-[5-bromo-1-(2,5-dimethylphenyl)-I H-pyrazol-4-y!]-21I-tetrazole; 1 -(4-bromobenzyl)-5-[5-bronio--(2,5-dimethyiphenyl)-1II-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzyl)-5-[5-hrorno-1 -(2,6-dimcthylphenyl)-1II-pyrazol-4-ylj-2H-tetrazo[e; -(4-bromobenzyl)-5-[5-bromo-1 -(2,6-dimethylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1-(3,4-dimethylpheny!)-1H-pyrazol-4-yl] -211-tetrazole; 1 -(4-bromobenzyl)-5-5-bromo-1 -(3,4-dimethyiphenyl)-1H-pyrazol-4-yIj-2H-tctrazole; 2-(4-brornobenzyl)-5-[5-bromo-1 -(3,5-dirnethylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-hromobenzyl)-5-[5-bromo-1-(3,3-climethylphenyl) -1II-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-I -(2-ethyiphenyl)-1H-pyrazol-4-yl]-2H-tetrazolc; 1 -( -bromohenzyl)-5-{5-bromo-1 -(2-ethyiphenyl)-I H-pyrazol-4-yl]-211-tetrazole; 2-(4-hromobenzyl)-5-[5-brorno-1-(4-ethylphcnyl)-I H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobenzyl)-5-[5-hromo-l -(4-ethylphenyl)-1H-pyrazol-4-yIj-2H-tetrazole; 2-(4-hromohenzyl)-5-[5-bromo-1-(4-rnethoxyphenyl)-l H-pyrazo!-4-yll-211-tetrazole; 1 -(4-bromobenzyl)-5-[5-brorno-1 -(4-methoixyphenyl)-1II-pyrazol-4-yl]-2H-tetrazolc; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2-mcthylphenyl)-1H-pyrazol-4-yIj-2H-tetrazole; 1 -(4-brornobenzyl)-5 -[5 -bromo-I -(2-niethylphenyl)-1}-f-pyrazol-4-yl] -211-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1 -(4-mcthylphenyl)-1II-pyrazol-4-yI]-2H-tetrazole; 1-(4-bromohenzyl)-5-[5-bromo-1-(4-methylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-hrornobenzyl)-5-(5-iodo-1-methyl-I H-pyrazol-4-yl)-2H-tetrazole; 1 -(4-brornobenzyl)-5-(5-iodo-1-mcthyl-1H-pyrazol-4-yl)-2H-teLrazole; 2-(4-bromobenzyI)-5-(1-ethy1-5-iodo-1Ii1-pyrazoI-4-y-2H-tctrazo1e; I -(4-brornobenzyl)-5 -(1 -ethyl-3-iodo-I H-pyrazol-4-yl)-2H-tetrazole; 2-(4-brornohenzyl)-5-[5-iodo-1 -(2-nietb1prop)-I H-pyTazol-4-yfl-2H-tctrazole; 1 -(4-bromobenzyl)-5-[5-iodo-1 -(2-methylpropyl)-1ll-pyrazol-4-yl]-211-tetrazole; 5-(1benzyh5-iodo-1H-pyrazo1-4-y1)-2-(4-brornobenzy1)-2H-tetrazoIe; 5-(1 -benzyl-5-iodo-1 H-pyrazol-4-yl)-2-(4-bromobenzyl)-2H-tetrazole; 2-(4-brornobenzyl)-5-(5-iodo-1 -phenyl-1H-pyrazol-4-yl)-2H-tetrazole; I -(4-bromobenzyl)-5-(5-iodo-1 -phenyl-1I-I-pyrazol-4-yl)-2H-tetrazole; 2-(4-brornobenzyl)-5 -[1 -(2-chlorophcnyl)-5-iodo-1 H-pyrazol-4-yl]-21-1-tctrazolc; 1 -(4-brornobenzyl)-5-[1 -(2-chlorophenyl)-5-iodo-1 H-pyrazol-4-ylj-2H-tetrazole; 2-(4-brornobcnzyl)-5-[1 -(3-ch1orophcny1)-5-iodo-1H-pyrazo1-4-y1-2H-tetrazo1e; 1 -(4-bromobenzyl)-5-[1-(3-chlorophenyl)-5-iodo-1 U-pyravoI-4-yl]-2H-tetrazole; 2-(4-hromohenzy!)-5-[1 -(4-ch1orophenyl)-5-iodo-1H-pyrazo1-4-y1-2H4etrazo1c; 1 -(4-hromobenzyl)-5-[1 -(4-chlorophenyl)-5-iodo-1 II-pyrazol-4-yll-211-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2,3-clichlorophenyl)-5-iodo-1ll-pyrazol-4-ylj-2H-tetrazole; 1 -(4-brornobenzy1)-5-1 -(2,3-dichlorophenyl)-5-iodo-IH-pyrazol-4-yl]-2U-tetrazole; 2-(4-brornobenzyl)-5-[T -(2,4-diehlorophenyl)-5-iodo-I ll-pyrazo!-4-yl]-2H-tetrazole; 1-(4-brornobenzyl)-5-[1-(2,4-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl] -2H-tetrazole; 2-(4-brornobenzyl)-5-[1 -(2.5-dich1orop1ieny1)-5-iodo-iH-pyrazo1-4-y1]2H-tetrazo1e; I -(4-bromobenzyl)-5-[ 1 -(2,5-dichlorophenyl)-5-iodo-11-I-pyrazol-4-yl]-2F1-tetrazolc; 2-(4-bromobenzyl)-5-[1 -(2,6-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-21i1-tetrazole; 1-(4-bromobenzy1)-5-1 -(2,6-diehlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2H4etrazole; 2-(4-brornobenzyl)-5-[1 -(3,4-dich[orophenyl)-5-iodo-IH-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobenzyl)-5-[1 -(3,4-dichlorophenyl)-5-iodo-IH-pyrazol-4-ylj-21-i-tetrazole; 2-(4-broinobenzyl)-5-[l-(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2T-1-tetrazole; I -(4-bromobenzyl)-5-[1 -(3,5-diehlorophenyl)-5-iodo-1 H-pyrazol-4-yll-211-tetrazole; 2-(4-hromohenzyl)-5-[1-(2-bromophenyl) -5-iodo-IH-pyrazol-4-ylj-2F1-tetrazole; 1 -(4-bromobenzyl)-5-[1 -(2-bromophenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazoic; 2-(4-brornobenzyl)-5-[I -(3-bromophenyl)-5-iodo-1 H-pyrazol-4-yI]-21-1-tetrazole; I -(4-bromohenzyl)-5-[I -(3-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(4-brornophenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-broniobenzyl)-5-[1 -(4-hromophenyl)-5-iodo-11 I-pyrazol-4-yl] -2}-1-tetrazole; 2-(4-bromobenzyl)-5-[1 -(4-fluorophenyl)-5-iodo-1H-pyrao1-4-y1]-2H-tetrazo1e; 1-(4-bromobenzyl)-5-[1 -(4-fluorophenyl)-5-iodo-11-T-pyrazol-4-yl]-211-tetrazolc; 2-(4-bromobcnzyl)-5-[1-(2-fluorophenyl)-5-iodo-1H-pyrazol-4-yl] -2F1-tetrazole; 1-(4-brornobenzy1)-5-I -(2-fluorophenyl)-5-iodo-I H-pyrazol-4-yI]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1 -(2,3-dirnethylphenyl)-5-iodo-IH-pyrazo]-4-ylj-2H-tetrazole; -(4-brornobenzyl)-5-[1 -(2,3-dimethy1phenyI)-5-iodo-lII-pyrazo1-4y1]-2I-I-tetrazo1e; 2-(4-brornobenzyl)-5-[1-(2,4-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl] -2H-tetrazole; 1 -(4-brornobenzyl)-541 -(2.4-dirnethylphcnyl)-5-iodo-T H-pyrazol-4-yIl-211-tetrazole; 2-(4-bromobcnzy1)-5-[1-(2,5-dimcthy1phcny1) -5-iodo-lH-pyrazo1-4-y1-2H-teIrazo1e; 1-(4-bromobenzyl)-5-[1 -(2,5-dirnethy1pheny1)-5-iodo-1M-pyrazo-4-y1j-2H-tetrazoIe; 2-(4-brornobenzy])-5-{1 -(2,6-dirnethylpheny!)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobenzyl)-5-[1 -(2,6-dirneL1iyphenv1)-5-iodo-1 H-pyrazol-4-yl]-2H-tctrazole; 2-(4-bi-oniobenzyl)-5-[1 -(3,4-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yll-21I-tetrazole; ao 1 -(4-brornobenzyl)-5-[1 -c,4-dimethylphenyl)-5-iodo-I H-pyrazol-4-y1]-2H-tctrazoe; 2-(4-bromobenzyl)-5-[1 -(3,5-diniethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-bromobenzy1)-5-[ -(3,5-dimethyphenyI)-5-iodo-1II-pyrazo1-4-y1j-2H-tetrazo!e; 2-(4-bromobenzyl)-5-[1 -(2-ethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; I -(4-bromobenzyl)-5-[1-(2-ethylphenyl)-5-iodo-IH-pyraz&-4-yI]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1-(4-ethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetr'azole; 1-.(4-brornohcnzyl)-5-{1 -(4-ethy1pheny1)5-iodo-1H-pyrazo1-4-y1j-2H-tetrazole; 2-(4-bromohenzyl)-5-[5-iodo-1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-21I-tetrazole; 1 -(4-bromobenzyl)-5-[5-iodo-1 -(4-rnethoxyphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-{5-iodo-1-(2-methylphenyl) -IH-pyrazol-4-ylIj-2fl-tctrazolc; 1 _(4-bromobenzy1)-5-5-iodo-1-(2-methyIpheny1)-1H-pyrazo1-4-y1] -2II-tetrazo1e; 2-(4-bromobenzy1)-5-L5-iodo--(4-methylphcnyl) -1H-pyrazol-4-ylj-2H-tetrazole; I -(4-bromobenzyl)-5-[5-iodo-1-(4-rnethylphenyl)-1 H-pyrazol-4-yl]-2H-tctrazole; 4-{[5-(1-methyl-1fI-pyrazol-4-yI)-2H-tetrazol-2-yl]methyl}benzonitrile; 4-{ L5-(1 -methyl-IH-pyrazol-4-yl)-1H-tetrazol-1-yl]methyl}benzonitrile; 4-{ [5-(1-cthyl-I H-pyrazol-4-yl)-21-I-tetrazol-2-yl]methyl)henzonitrilc; 4-{[5-(1-ethyl-1H-pyrazoL-4-yl)-IH-tetrazol-1-yl]niethyl}henzonitrile; 4-({ 5-[1 -(2-methylpropyl)-1 H-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)benzonitrile; 4-({5-I 1 -(2-methylpropyl)-1II-pvrazol-4-yl]-IH-ietrazol-1-yl}rnethyl)benzonitrile; 4-{[5-(1-benzyl-1H-pyrazol-4-yI)-2H-tetrazol-2-yllmethyl}benzonitrile; 4-{[5-(1-benzyl-lI-1-pyrazol-4-yl)-1H-tetrazol-1-yl]rnethyl}benzonitrile; 4-{[3-(1-phcnyl-1H-pyrazol-4-yl)-211-tetraz6l-2-yfjrnethyl}henzonitri!e; 4-{ [5-(1 -phenyl-1 H-pyrazol-4-yl)-1 II-tctrazol-1 -yl]methyl}benzonitrile; 4-({ 5-[l -(2-chlorophenyl)-1H-pyrazol-4-ylj-2H-tetrazol-2-yl} methy!)henzonitrfle; 4-((5-[1 -(2-chiorophenyl)-I H-pyrazo!-4-yll-1H-tctrazol-1 -yl}rnethyl)benzonitrile; 4-({5-[1-(3-chlorophenyl)-likpyrazol-4-ylj-2H-tetrazol-2-yI}rnethyl) bcnzonitrile; 4-({5-[1 -(3-chlorophenyl)-1 1-1-pyrazo]-4-yI]-I 1-1-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1 -(4-chlorophenyl)-IU-pyrazol-4-ylj-2H-tetrazol-2-yI}rnethyl)henzonitrile; 4-({5-[1-(4-chlorophenyl)-1H-pyrazol-4-yl]-IH-tetrazol-1 -y}methyI)henzonitri1e; 4-({5[1-(2,3-dich1oropheny1)-I H-pyrazol-4-yl]-21T-tetrazol-2-yl)rnethyl)benzonitrile; 4-({5-[1 -(2,3-dichlorophenyl)-1II-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl) henzonitrile; 4-({5-[1 -(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl)methyl) benzonitrile; 4-(5-[1-(2,4-dich1oropheny1)-1H-pyrazo1-4-y1j-1 H-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(2,5-dich]orophenyl)-I H-pyrazol-4-yI]-21I-tctrazol-2-yl}methyl)benzonitrile; 4-({5-[1 -(2,5-dicNoropheny1)-1H-pyrazo1-4-y1]-1Ii-tetrazo-I -yl}methyl)henzonitrilc; 4-({5-[1-(2,6-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}nwthyl) benzonitrile; 4-({ 5-[1-(2,6-dich!orophenyl)-IH-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl) benzonitrile; 4-({5-[1 -(3,4-dichlorophenyl)-1H-pyrazol-4-yfl-211-tetrazol-2-yl}methyl) benzonitrile; 4-({ 541 -(3,4-dichiorophenyl)-1I-1-pyrazol-4-yI]-1 H-tetrazo!-1 -yl}mcthyl)benzonitrile; 4-({5-[1-(3,5-dichlorophenyl)-11-{-pyrazol-4-yI]-2T-I-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[1-(3,5-dichlorophenyl)-1TI-pyrazol-4-yl]-1H-tetrazol-1-yl)rnethyl) benzonitrile; 4-({5-[i -(2-bromophenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[1 -(2-brornophenyl)-1 H-pyrazol-4-yI j-1 H-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(3-bromopheny-1 H-pyrazol-4-yll-2H-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-[1-(3-brornopheny1)-1H-pyrazo1-4y1j-iH-tetrazoI-1 -yl}methyl)benzonitrile; 4-({ 5.41 -(4-bromophenyl)-I H-pyrazol-4-yLj-21-1-tetrazol-2-yl}rnethyl)benzonitrile; 4-5-fl -(4-bromophcnyl)-IH-pyrazol-4-yl]-IH-tetrazol-I -yl}methyl)benzonitrile; 4-({ 5-[1 -(4-fluorophenyl)-1I-I-pyrazol-4-yI]-2H-tetrazol-2-yl}mcthyl)benzonitrile; 4-({5-[1-(4-tluorophenyl)-1H-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl) benzonitrile; 4-( {5-[ I -(2-fluorophenyl)-1H-pyrazol-4-yll-21T-tetrazol-2-yl}rnethyl)henzonitrile; 4-({5-[1-(2-fluorophenyl)-IH-pyrazol-4-yIj-1 H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[1 -(2,3-dimethylphenyl)-I H-pyrazol-4-ylIj-2H-tetrazol-2-yl}methyl)benzoniirile; 4-({ 5-[1 -(2,3-dimethyiphenyl)-1fl-pyrazol-4-yIJ-1 H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-{1 -(2,4-dirnethylphenyl)-1H-pyrazol-4-yI]-21-T-tetrazol-2-yl}methyl) benvonitrile; 4-({5-[1 -(2,4-dirnethylphenyl)-1 T-f-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl)hcnzonitrile; 4-({5-[1 -(2.5-clirnethylphenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yI}methyl) benzonitrile; 4-({5-[1 -(2,5-dimethylplienyl)-1H-pyrazol-4-yl]-1II-tetrazol-1-yl}rnethyl) benzonitrilc; 4-({5-[1-(2,6dirnethyIphcnyI)-1FI-pyrazo1-4-y1]-2H-ietrazo1-2-yI}methyI) benzonitri1e; 4-({5-[I _(2,6_dimethylphenyl>-1H-pyrazol-4-yIIl-1II-tetrazol-1-yl}methyl) benzonitrile; 4-({5-[1 -(3,4-dirnethylphenyl)-1 H-pyrazol-4-yli-2H-tctrazoL-2-yl}rnethyl)benzonitrile; 4-({5-[1-(3,4-dimethy1pheny1)-11-T-pyrazo1-4-y1-1II-tetrazoL-1-y1}rnethyl) benzonitri1e; 4-U5-[1 -(3,5-dirnethylphenyl)-1 H-pyrazol-4-yI]-2H-tetrazol-2-yl}mcthyl)bcnzonitrile; 4-({5-[1 -(3,5-dimethy!phenyl)-1 H-pyrazol-4-yl]-1H-tctrazol-1 -yl}methyl)benzonitrile; S 4-({5-[1 -(2-ethylphenyl)-1ll-pyrazo1-4-y1-2II-tetrazo1-2-yl}methy1)benzonitri1e; 4-({5-[1-(2-ethylphenyl)-1H-pyrazok4-vl]-11-1-tetrazol-1-yl}rnethyl) benzonitrile; 4-( {5-[ I -(4-ethylphenyl)-1 11-pyrazoh4-yll-211-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[1 -(4-ethylphenyl)-I H-pyrazo1-4-y1-1 1-1-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[1 -(4-rnethoxypheny1)-1II-pyrazol-4-y1]-2H-tetrazol-2-y}rnethyI) benzonitri1e; 4-({5-[1-(4-rnethoxyphenyl)-11-I-pyrazol-4-ylj-1 H-tetrazold -yI}methyl)benzonitrile; 4-( fS-[l -(2-methylpheny[)-1 H-pyrazol-4-y1]-21-T-tetrazo1-2-y1}methy)benzonitri1e; 4-((5-[1 -(2-methylphenyl)-1H-pyrazol-4-yl]-IH-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[1 -(4-rnethylphenyl)-1ll-pyrazol-4-ylj-2H-tetrazol-2-yl}methyl)benzonitri!c; 4-({5-[I -(4-niethy[phenyl)-H-pyrazo!-4-yI]-1H-tetrazol-1-yl)rnethyl)benzonitrile; 4-{ [5-(5-ehloro-1 -methyl-1H-pyrazol-4-yl)-2H-tetraz&-2-yllmethyl}benzonitrile; 4-{ [5-(5-ehloro-1-methyl-1H-pyrazol-4-yl)-IH-tetrazol-1 -yI}methyl}henzonitrile; 4-{ 15-(5-ehloro-1-ethyl-1M-pyrazol-4-yD-2H-tetrazol-2-yllrnethyl) henzonitrile; 4-{ [5-(5-chloro-1 -etIiy-1H-pyrazo-4-y1)-1II-tetrazo1-1-y1]rnethy}benzonitri1e; 4-({5-[5-chloro-1-(2-methylpropyl )-1H-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-chloro-1 -(2-methyipropyl)-I 1-f-pyrazol-4-yI]-1 H-tetrazol-1 -yl}methyl)benzonitrile; 4-{[5-(1 -henzyl-5-chloro-1I-I-pyrazol-4-yl)-211-tetrazol-2-yljmethyl}benzonilrile; 4-{[5-(1-benzyl-5-chloro-1H-pyrazol-4-yl)-1H-tetrazol-1-yl]methyl} bcnzonitrile; 4-{[5-(5-chloro-l-phenyl-1 H-pyrazol-4-yI)-21-1-tetrazol-2-yllmethyl}benzonitrile; 4-{ [5-(5-chloro-1 -phenyl-1II-pyrazol-4-yl)-1 H-tetrazol-1 -yl]methyl}benzonitrile; 4-({5-[5-ehloro-1-(2-chlorophenyl)-1H-pyrazol-4-ylj-2H-tetrazol-2-yl) rnethyl)bcnzonitrile; 4-e5-L5-chioro-1 -(2-eh1orophenyl)-H-pyrazo!-4-yl]-1II-tetrnzol-1-yl}methyl)benzonitrile; 4-({5-[5-cbloro-1 -(3-ehlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)benzonilrile; 4-({5-[5-chloro-1 -(3-ehiorophenyl)-IH-pyrazol-4-yfl-1H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-ehloro-1 -(4-ehlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}met.hyl)benzonitrile; 4-({5-[5-chloro-1-(4-chlorophenyl)-1II-pyrazol-4-yl]-1H-tetrazol-1 -yI}methyl)benzonitriie; 4-({5-[5-ehloro-1-(2,3-diehlorophenyl)-1 H-pyrazol-4-yI]-2H-tctrazol-2-yl}methyl)benzonitrile; 4-({5-{5-ehloro-1-(2,3-diehlorophenyl)-I H-pyrazol-4-yi]-IH-tetrazol-1-yl}methyl)benzonitrile; 4-( {5-[5-chloro-1 -(2,4-dichiorophenyl)-I H -pyrazok4-yl] -2H-tetrazol-2-yl} rnethyl)benzonitrile; 4-({5-[5-ehloro-1 -(2,4-dichlorophenyl)-IH-pyraiol-4-yl]-l T-I-tetrazol-1 -vI} methyl)benzonitrile; 4-({5-[5-chloro-1 -(2,5-diehlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}methy!) benzonitrile; 4-({5-[5-chloro1-(2,5-clichlorophenyl)-1II-pyrazol-4-yl]-1H-tetrazol-1-vi} methyflbenzonitrile; 4-({5-[5-ehloro--(2,6-dichlorophenyl)-1ii-pyrazok4-yl]-2H-tctrazol-2-yl} methyl)bcnzonitrile; 4-({5-[5-chloro-1-(2,6-dichlorophenyl)-1II-pyrazol-4-yfl-1H-tetrazol-1-yl} methyl)henzonitrilc; 4-({5-[5-ehbro-1 -(3.4-diehlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)benzonitri Ic; 4-({545-chloro-1 -(3,4-dichlorophenyl)-1H-pyrazol-4-ylj-1 H-tetrazol-1 -yl} rnethy])benzonitrUe; 4-({5-[5-chloro-1-(3,5-dichlorophenyl) -1H-pyrazol-4-yIIl-211-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-{5-chloro-1 -(3,5-dichlorophenyl)-1H-pyrazoi-4-ylj-1II-tetrazol-1-vl}methyl) benzonitrilc; 4-5-[5-eh1oro-1 -(2-hromopheny1)-1H-pyrazo1-4-y-2H-tetrazoi-2-y1}methy1)benionitri1e; 4-({5-[5-chloro-1 -(2-bromophenyl)-I H-pyrazo1-4-yfl-1i-I-tetrazo1-1-y1}methy)benzonitriie; 4-({5-[5-ehloro-I -(3-bromophenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-[5-chioro-1 -(3-bromophenyl)-IH-pyraz&-4-yI]-1 H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-cbloro-1-(4-bromophenyl)-I H-pyrazol-4-yll-211-tetra2ol-2-yl}methyl)benzonitrile; 4-({5-[5-chloro-1 -(4-brornophenyl)-1H-pyrazol-4-yll-1H-tetrazol-I -yi}niethyl)bcnzonitrile; 4-V5-L5-chloro-I -(4-fluorophenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)benionitrile; 4-( (5-[5-chloro-1 -(4-tluorophenyl)-1H-pyrazol-4-yll-1 H-tetrazol-1 -yl}methyl)benzonitrilc; 4-({5-[5-chloro-I -(2-fluorophcnyl)-1I-I-pyrazol-4-ylj-21-1-tetrazo!-2-yl}mcthyl) benzonitrile; 4-({5-[5-ehloro-I -(2-fluorophenyl)-1 H-pyrazol-4-yI]-1H-tetrazol-1-yl}methyl)henzonitri!e; 4-({5-[5-chloro-1-(2.3-dimethylphenyl)-I H-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)bcnzonitrile; 4-((5-[5-chloro-1 -(2,3-dimethyiphenyl)-1 H-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[5-chloro-1 -(2,4-dimethylphenyl)-1II-pyrazol-4-yI]-2H-tetrazoh2-yl} mcthyl)benzonitrile; 4-({5-[5-chloro-I -(2,4-dimethylphcnyl)-1H-pyrazol-4-yl]-1 H-tetrazol-1 -yl}rnethyl)benzonitrile; 4-({5-[5-chloro-1-(2,5-dimethylphenyl)-1R-pyrazol-4-yfl-211-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-chloro-1 -(2,5-dimethylphenyl)-114-pyrazol-4-ylI-1I-I-tetrazol-1-yl} rnethyl)benzonitri Ic; 4-({5-[5-cbloro-1-(2,6-dirnethylphenyl)-I H-pyrazol-4-yl]-21-I-tetrazol-2-yl} rnethyl)benzonitri Ic; 4-({5-[5-ehloro-1 -(2,6-dimethylphenyl)-1H-pyrazol-4-yI]-UT-tetrazol-1-yl} methy)benzonitri1e; 4-({5-[5-chloro-1-(3,4-dimethylphenyl)-1II-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-chloro-1-(3,4-dimethylphenyl)-1 H-pyrazol-4-yl]-1H-tetrazol-1-yl} inethyl)benzonitrile; 4-({5-[3-chloro-J -(3,5-dirnethylphcnyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl} rnethyl)henzonitrile; 4-({5-[5-chloro-1-(3,5-dimethylphcnyl)-I I-T-pyrazol-4-ylj-1 H-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[5-ehloro-1 -(2-ethylphenyl)-1H-pyrazoi-4-yI]-2H-tetrazol-2-yl}methyl)benzonitrilc; 4-({5-[5-chloro-1-(2-ethyiphenyl)-I H-pyrazol-4-yl]-1T-I-tetrazol-I -yl}methyl)benzonitrile; 4-({5-[5-chloro-I -(4-ethyiphenyl)-1H-pyrazol-4-y1j-2H-tetrazo1-2-yl}methybenzoni1ri1e; 4-({5-[5-chloro-1-(4-ethylphenyl)-1 H-pyrazoI-4-y1-1Ii--tetrazo1-1-y1}methy1)bcnzonitriIe; 4-({5-[5-chloro-1 -(4-methoxyphcnyl)-l T-1-pyrazol-4-yl]-2H-tetrazol-2-yI}niethyl)benzonitrile; 4-({5-[5-chloro-] -(4-methoxyphcnyl)-1H-pyrazol-4-yl]-1 H-tetrazol-I-yl}methyl)benzonifrile; 4-({5-[5-ehloro-1 -(2-methylphenyl)-1FI-pyrazol-4-yl]-2H-tctrazol-2-yl}rneihyl)benzonitrile; 4-({5-[5-chloro-1 -(2-methylphenyl)-1H-pyrazol-4-yl]-1H-tetrazol-I -yI}methyl)benzonitrilc; 4-({5-[5-chloro-1 -(4-inethyiphenyl)-1II-pyrazol-4-yI]-2H-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[5-chloro-1 -(4-methylphenyl)-I F-1-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl)benzonitrile; 4-{[5-(5-brorno-1-methyl-I H-pyrazol-4-yl)-2H-tetrazol-2-yljniethyl}henzonitrile; 4-{[5-(5-brorno-I -methyl-1II-pyrazol-4-yI)-1 H-tetrazol-1-yl]inethyl}benzonitrile; 4-{[5-(5-bromo-1 -ethyl-11-1-pyrazol-4-yI)-2H-tetrazol-2-yl]methyl}benzonitrile; 4-{ [5-(5-bromo-I -ethyl-IH-pyrazol-4-yl)-1H-tetrazol-1-yI]rncthyl}benzonitrile; 4-({5-[5-bromo-1-(2-methylpropyl)-1I-I-pyrazol-4-yl]-2H-tetrazol-2-yl} rnethyl)benzonitriie; 4-({5-[5-bromo-1-(2-methy1propy1)-1i-I-pyrazoh4-y1]-1H-tetrazo-1 -yl}methyl)henzonitri!e; 4-{[5-(1-henzyl-5-bromo-IH-pyrazol-4-yl)-2H-tctrazol-2-yl]mcthyl} bcnzonitrile; 4-{ [5-(1-benzyl-5-bromo-1H-pyrazol-4-yl)-1H-tetrazol-1 -yflmethyl}benzonitrile; 4-{ [5-(5-bromo-1-phenyl-1H-pyraz6l-4-yl)-2H-tetrazol-2-yl jmethyl} benzonitrile; 4-{ [5-(5-brorno-1 -phcnyl-1H-pyrazol-4-yl)-1H-tetrazol-1-yl]methyl}benzonitrile; 4-({5.-[5-brorno-1-(2-ehlorophenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-y!} methyl)benzonitrilo; 4-({5-[5-bromo-1-(2-eh1oropheny)-1II-pyrazo1-4-y1j-iB-tetrazo]--yl} rnethyl)henzonitrile; 4-({545-brorno-1-(3-chiorophenyl)-IH-pyrazol-4-ylj-2H-tetrazo]-2-yl} mcthyl)henzonitrile; 4-({5-[5-bromo-1 -(3-chlorophenyi)-1 I-1-pyrazol-4-yll-1II-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[5-brorno-1-(4-ch1oropheny-1II-pyrazo1-4-y1I-2H-tetrazo1-2-y1} methy1)benzonitri1e; 4-({5-[5-bromo-1-(4-chlorophenyl)-1H-pyrazol-4-ylj-IH-tetrazcfl-1 -yI}nicthyl)benzonitrile; 4-({5-[5-bromo-1(2,3-dich1oropbeny])-1 H-pyrazol-4-yl]-21-1-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-brorno-1-(2,3-diehlorophenyl)-IH-pyrazol-4-yl]-1 H-tctrazo!-1 -yl}methyl)benzonitrile; 4-({5-[5-bronio-I -(2,4-dichlorophenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-( { 5 -5 -bromo-I -(2,4-dichiorophenyl)-1H-pyrazol-4-yll-111-tetrazol-1-yl} nicthyl)benzonitrile; 4-5-[5-bromo-1 -(2.5-dichloroplienyl)-I H-pyrazol-4-yfl-2H-tetrazol-2-yl}rncthyl)bcnzonitrile; 4-({5-[5-bromo-1-(2,5-dichlorophenyl)-1H-pyrazol-4-yl]-1H-tctraz&-I -yl]* methyl)benzonitrile; 4-({5-5-brorno--(2,6-dichlorophenyl)-1II-pyrazol-4-yl]-2H-teirazol-2-yl} methyl)benzonitrile; 4-( { 5-[5-bromo-1 -(2,6-dichlorophcnyl)-I H-pyrazol -4-yli-II 1-tetrazol-1-yI}mcthyl)henzonitrile; 4-0 5-[5-brorno-I -(3,4-dichiorophenyl)-i-T-pyrazol-4-yl]-2H-tctrazol-2-yl} methyl)benzonitri Ic; 4-({5-[5-brorno-1-(3,4-dichlorophenyl)-1II-pyrazol-4-y]j-I l-I-tetrazol-I -yl}methyl)benzonitrile; 4-({5-[5-brorno-l-(3.5-dich1oropheny1)-1II-pyrazo1-4-yj-2H-terazoI-2-yl} methyl)benzonitrile; 4-({5-[5-bromo-1-(3.5-dichlorophenyl)-1TI-pyrazol-4-yl]-IM-tetrazoi-1 -yl} methyl)benzonitrile; 4-({5-[5-bromo-1 -(2-bromophenyl)-1H-pyraz6l-4-yl]-21-T-tetrazoL2-yl}rnethyl)benzonitrile; 4-({5-5-hromo-I -(2-bromopheny[)-l F1-pyrazol-4-yl]-11-1-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[5-bromo-1 -(3-bromophenyl)-1 H-pyrazo1-4-y1]-2H-tetrazo1-2-y}rnethy1)benzonitri1e; 4-({5-[5-bromo-I -(3-bromopheny[)-1II-pyrazol-4-yl]--1H-tetrazol-1-yl}methyl)henzonitrile; 4-({5-[5-bromo-1 -(4-bromopheny1)l H-pyrazol-4-yl]-21-I-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[5-bromo-l-(4-broniopheny1)-lH-pyrazol-4-y1]-1H-tetrazo-I -yI}methyl)benzonitrile; 4-({5-[5-bromo-1-(4-fluorophenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-y!} methyl)benzonitrile; 4-5-[5-bromo-I -(4-fluorophcnyl)-lII-pyrazol-4-yl]-1H-tetrazol-1 -yl}rnethyl)benzonitrile; 4-({5-[5-hrorno-l-(2-fluorophenyl)-1H-pyrazol-4-yl]-211-telrazoi-2-yl} rnethvl)benzonitrile; 4-({5-[5-bromo-l -(2-fluorophenyfl-1 H-pyrazol-4-yl]-I H-tetrazol-I -yl}rnethyi)benzonitrile; 4-( { 5-[5 -bromo-1 -(2,3 -dirnethylphenyl)-I H-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-hrorno-1-(2,3-dimethylphenyl)-1H-pyrazol-4-yl]-1 H-tetrazo!-I -yl} methyl)benzonilrile; 4-( { 5-[5 -bromo-1 -(2,4-diniethyiphenyl)-I fl-pyrazo1-4-yl]-21 I-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-brorno-1 -(2,4-dimethylphenyl)-1II-pyrazol-4-yl]-1H-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[5-brorno-1 -(2,5-dimethylphenyl)-I I-f-pyrazol-4-yll-21I-tetrazol-2-yl} rnethyl)henzonitrile; 4-({5-[5-bromo-1-(2,5-dimelhylphenyl)-1H-pyraz5l-4-yl]-I H-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-L5-brorno-I -(2,6-dimethylphenyl)-1H-pyrazol-4-yF]-211-tetrazol-2-yl} rnethyl)benzonilrile; 4-({5-[5-bromo-1 -(2,6-dimethylphenyl)-l H-pyrazol-4-yl]-1H-tetrazol-1-yl} methyi)berizonitrile; 4-( (5-[5-bromo-1 -(3,4-dirnethylphenyl)-I H-pyrazol -4-y!]-2H-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-[5-bromo-1 -(3,4-dimethylphenyl)-1H-pyrazol-4-yl]-1H-tetrazol--yl} methyi)benzonitrile; 4-({5-[5-brorno-1 -(3,5-dimethyiphenyl)-1H-pyrazol-4-yij-2H-tetrazol-2-vi). methyl)benzonitrile; 4-({5-[5-bromo-1-(3,5-dimethy1pheny1)-1IT-pyrazo1-4-y1-1II-tetrazo1-1-yl} rneihyl)benzonitrile; 4-({5-[5-bronio-1 -(2-ethylphcriyl)-I H-pyrazo-4-y1J-2H-tetrazo1-2-yI}methy1)benzonitri1e; 4-({ 5-[5-bromo-1 -(2-ethyiphenyl)-1II-pyrazol-4-yl]-1II-tetrazol-1 -yl}melhyl)benzonitrile; S 4-({5-[5-bronio-1-(4-ethy1pheny)-T-T-pyrazol-4-yl]-2H-tetrazol-2-yI} methyl)henzonitrile; 4-(j 5-[5-bromo-I -(4-ethyiphenyl)-II I-pyrazol-4-yll-1II-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-brorno-1-(4-rnethoxyphenyl)-1H-pyrazol-4-ylj-2H-tetrazo]-2-y]} methyl)benzonitrile; 4-({ 5-[5-bromo-1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-1H-1etrazol-1 -yl}rnethyl)benzonitrile; 4-({545-bromo-.i-(2-rnethy1phcny)-I H-pyrazol-4-yIj-2H-tetrazol-2-yI}methyl)benzonitrile; 4-({5-[5-bromo-1 -(2-methylphenyl)-1II-pyrazol-4-yli-111-tetrazol-1 -yl}rnethyl)benzonitrile; 4-({5-[5-bromo-1-(2-rnethy1pheny1)-1H-pyra2o1-4-y1-2H-tetrazo1-2-y1} rnethy1) benzonitrile; 4-({5-[5-bromo-] -(2-methylphenyl)-1 H-pyrazol-4-yfl-I H-tetrazol-I -yl}methyl) henzonitrile; 4-{ [5-(5-iodo-1-methyl-1H-pyrazol-4-yl)-2H-tetrazol-2-yl]methyl} bcnzonitrilc; 4-{[5-(5-iodo-1-methyl-1II-pyrazol-4-yl)-1II-telrazol-1-yl]methyl} benzonitrile; 4-{[5-(1-ethyl-5-iodo-1I-I-pyrazol-4-yl)-21-I-tetrazol-2-yljmethyl} benzonitrile; 4-{{5-( -ethyl-5-iodo-1 H-pyrazol-4-yl)-1 H-tetrazol-1 -yl]rnethy! } bcnzonitrilc; 4-({5-[5-iodo-1 -(2-mcthylpropyl)-1H-pyraz&-4-yl]-2T-I-tetraz6l-2-yl}methyl) benzonitrile; 4-({5-5-iodo-1-(2-rnethy1propy1)-1 H-pyraz&-4-ylj-1 H-tctrazol-1 -yI}methy[) benzonitrile; 4-{[5-(1 -henzyl-5-iodo-IH-pyrazol-4-yl)-211-tetrazol-2-yllmethyl}benzonitrile; 4-{[5-(1-benzyl-5-iodo-IH-pyrazol-4-yl)-1H-telrazol-1-yl]rnethyl} benzonitrile; 4-{[5-(5-iodo-1-phenyl-I H-pyrazoI-4-y)-2H-tetrazoI-2-y1]mcthyl}henzonitriIe; 4-{[5-(5-iodo-1-phenyl-IH-pyrazol-4-yl>-1H-tetrazol-1-yl]rnethyl} benzonitrile; 4-({5-[1-(2-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazol-2-yl} rnethyl)benzonitrile; 4-({5-[1 -(2-chlorophenyl)-5-iodo-I 1-T-pyrazol-4-yl]-1 H-tetrazol-I -yl}methyl)benzonitrile; 4-({5-[1 -(3-ehlorophenyl)-5-iodo-1II-pyrazol-4-yfl-211-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[1 -(3-chlorophenyl)-5-iodo-1II-pyrazol-4-yll-1II-tetrazol-1 -yl}rnethyl)benzonitrile; 4-({5-[1 -(4-ehloropheny])-5-iodo-I N-pyrazol-4-yI]-2H-tetrazol-2-yflrnethyl)benzonitrile; 4-({5-[1 -(4-chlorophenyl)-5-iodo-1JJ-pyrazol-4-yl]-IH-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(2,3-diehlorophenyl)-5-iodo-1H-pyrazol-4-ylj-2H-tetrazol-2-yl} niethyl)henzonitrile; 4-({5-{1 -(2,3-diehlorophcnyl)-5-iodo-1H-pyrazol-4-yl]-lH4etrazol-1-yl}methyl) benzonitrilc; 4-({5-{1 -(2,4-dichlorophenyl)-5-iodo-1 I1-pyrazol-4-yl]-211-tetrazol-2-yl}rnethyl)benzonitrile; 4-({ 5-[] -(2,4-dic]ilorophenyl)-5-iodo-H-pyrazol-4-yI]-1H-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-11 -(2,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2T-I-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[1 -(2,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1H-tetrazol-1-yl}methvl) benzonitrile; 4-({5-[1-(2,6-dich1oropheny)-5-iodo-1 H-pyrazol-4-yl]-2H-tctrazol-2-yl}methyl)benzonitrile; 4-({5-[1-(2,6-dichlorophenyl)-5-iodo-1 I-T-pyrazo1-4-y1-1II-tetrazo1-1-y1}methyI)benzonitri1e; 4-({5-{1 -(3,4-dichlorophenyl)-5-iodo-1 H-pyrazo1-4-yI]-2H-tctrazo1-2-y}methyl)benzonitriIe; 4-({5-[1-(3,4-dichiorophenyl)-S-iodo-1 H-pyrazoI-4-y1]-1I-I-tetrazo1-1-y1methy1)benzonitri1c; 4-({5-[ -(3,5-dichlorophenyl)-5-iodo-IH-pyrazol-4-yl]-2H-teftazol-2-yI}methyl) henzonitrile; 4-({3-11-(3,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1 H-tctrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(2-brornopheny1)-5-iodo-1II-pyrazo1-4-y1]-2H-tetrazo1-2-y1} rnethy1)benzonitri1e; 4-({5-[1-(2brornopheny)-5-iodo-1 I-i-pyrazol-4-yl]-1II-tetrazol-1 -yl}rnethyl)bcnzonitrile; 4-({5-[1 -(3-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl) benzonitrile; 4-({5-[1 -(3-brornophenyl)-5-iodo-1 H-pyraz&-4-yl]-I T-I-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(4-brornophenyl)-5-ioclo-1 F-I-pyrazol-4-yl]-2T-1-tctrazol-2-yl}melhyl)benzonitrilc; 4-({5-[1-(4-bromophenyI)-5-iodo-1H-pyrazo1-4-y1]-III-tetrazo1-1-y1} rnethybenzonitri1c; 4-({5-[I -(4-fluorophenyl}-5-iodo-1 II-pyrazol-4-ylj-2H-tetrazol-2-yl} methyl)benzonilrile; 4-({5-[1-(4-fluorophenyl)-5-iodo-1 H-pyrazol-4-y!]-1H-tctrazol-1-yl}methyl)benzonitrile; is 4-({5-[1 (2-fluoropheny1)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)henzonitrilc; 4-({5-[1-(2-fiuorophcnyl)-5-iodo-1II-pyrazol-4-yl]-1 H4etrazol-1 -yl}rncthyl)benzonitrile; 4-({5-[1 -(2,3_dimethy1pheny1)-5-iodo-1H-pyrazo1-4-y1]-2H-tetrazo-2-y1}rnethy1) benzonitri1e; 4-({5-[1-(2,3-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1H-tetrazol-1 -yI}rnethyl)benzonitrile; 4-({5-[1 _(2,4_dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl) beflzoflitrilc; 4-({5_[1_(2,4-dirnethylphenyl)-5-iodo--I1-I-pyrazol-4-yl] -1H-Lelrazol-1-yl}mcthyl)henzonitrile; 4_({5[h(2,5-dimethy1pheny)-5-iodo-1H-pyrazo1-4-y1]-2H-tctrazo1-2-y!) methy1)benzonitri1e; 4-({3-[1-(2,5-dimethy1pheny1)54odo-1 H-pyrazo1-4-y1-1II-tetrazo1-1-y1}rnethy1)bcnzonitriIe; 4_({3-[1-(2,6-dirnethylphenyl)-5-iodo-1T-T-pyrazol-4-yl]-2H-ietrazoL2-yl} methyl)benzonitrile; 4-({5-[1-(2.6-dimethylphenyl)-5-iodo-IH-pyrazol-4-yl]-1H-tetrazol--1 -yl}methyl)benzonitrile; 4-({5-[I -(3,4-dirncthylphenyl)-5-iodo-IIEI-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl) benzonitrile; 4-( {5-[1_(3,4-dimethylphenyl)-5-iodo-IH-pyrazol-4-yl]-IH-tetrazol-1-yl} rnethyl)benzonitrile; 4_({5-[1-(3,5-dimethylpheny!)-5-iodo-1H-pyrazol-4-yl]-21I-tetrazol-2-yI} methyl)benzonitrile; 4_(f5-[1_(3,5-dirnethy1phenyI)-5-iodo-1H-pyrazo1-4-y1]-1H-tctrazo1-1-y1} methyhenzonitri1e; 4_({5-[1-(2-ethy1pIieny)-5-iodo-1H-pyrazo1-4-yl]-2II-tetrazo1-2-y1}methyI) benzonitri1e; 4-({5-[1-(2-ethylphenyl)-S-iodo-1FI-pyrazol-4-yfl-1 H-tetrazol-1-yl}methyl)benzonitrile.; 4-({5-[1 -(4-ethy1pheny1)-5-iodo-1H-pyazo-4-yl]-2H-tetrazo1-2-y1)methy) henzonitri1e; 4-({5-[1-(4-ethylphcnyl)-5-iodo-1II-pyrazol-4-ylj-1H-tetrazol-1 -yl}rncthyl)henzonitrile; 4-({5-[5-iodo-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl} rnethyl)beflzonitrile; 4-({5-[5-iodo-1_(4-rncthoxypheny1)-1II-pyrazo1-4-y1j-1H-tetrazo1-1-yI} rncthyI)henzonitri1e; 4-({545-iodo-1 -(2-niethylphenyl)-1H-pyrazol-4-yll-211-tetrazol-2-yl}rnethyl) benzonitrile; 4-({S-[5-iodo-1 -(2-methylphenyl)-1Ii-pyrazol-4-yl]-I H-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5_[5_iodo-1-(4-methylphenyl)-1H-pyrazol-4-ylI-211-tetrazol-2-yl} methyl)benzonitrile; 4-({5_[5_iodo-1_(4-mcthylphenyl)-IH-pyrazol-4-yl]-1H-tetrazol-1-yl}methyl) beflZOflitrile; 2-(4-methoxybenzyl)-5-(1-methyl-1H-pyrazol-4-yI)-2H-tetrazole; I -(4-methoxybenzyl)-5-( 1 -methyl -l H-pyrazoi-4-yl)-21 1-tetrazole; 5-( I -ethyl-I H-pyrazol-4-yl)-2-(4-rnethoxybenzyl)-2H-tetrazole; 5--cthyl-I H-pyrazol-4-yl)-1-(4-rnethoxybenzyl)-2H-tetrazole; 2-(4-methoxybenzyl)-5-[I -(2-methyipropyl)-1 H-pyrazol-4-yl]-211-tetrazole; 2-(4-rnethoxybenzyl)-541-(2-methylpropyl)-IH-pyrazol-4-yl]-2H-tetrazole; 5-@ -benzyl-1 I-1-pyrazol-4-yl)-2-(4-methoxybcnzyl)-2H-teftazole; 5-(1-benzyl-1H-pyrazol-4-yl)-I-(4-methoxybenzyl)-2H-tetrazole; 2-(4-methoxyberizyl)-5-( 1-phenyl-1 1-1-pyrazol-4-y!)-2H-tctrazole; 1-(4-methoxybenzyi)-5-(l -phenyl-1H-pyrazol-4-yl)-2T1-tetrazole; 5-[ 1 -(2-ehiorophenyl)-I H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H -tetrazole; 5-11 -(2-ehlorophenyl)-1II-pyrazol-4-y]j-I -(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(3-chiorophenyl)-I H-pyrazol-4-yl]-2-(4-methoxyhenzyl)-211-tetrazole; 5-[1 -(3-ehlorophenyl)-1iI-pyrazol-4-yl]-1-(4-rnethoxybenzyl)-2H-tetrazole; 5-LI _(4_ch1oropheny1)1Hpyrazo1_4y1j_2(z_mcthoxybenzy1)-2II-tetrazo1e; 5-[1-(4-chlorophenyl)-l H-pyrazol-4-yl]-1-(4-methoxybenzyl)-2H-tetrazole; 5-[ I -(2,3-dichlorophenyl)-1 H-pyrazol-4-y1J-2-(4-rnethoxybenzy-2FI-tetrazo1e; 5-11 -(2,3-dichiorophenyl)-1i-i-pyrazol-4-yI]-I -(4-methoxybenzyl)-2H-tetrazole; 5-[1-(2,4-dichlorophenyl)-1 I-1-pyrazo1-4-y1-2-(4-rnethoxybenzy1)-2H-tetrazoIe; 5-1-(2,4-dich!oropheny1)-1H-pyrazo1-4-yl]-1-(4-rnethoxybenzyI) -2H-tetrazo1e; 5-LI -(2.5-dichlorophenyl)-1IT-pyrazol-4-yl]-2-(4-methoxybenzyl)-211-tetrazole; 5-[l -(2.5-dichlorophenyl)-l H-pyrazol-4-yl}-l-(4-methoxybeniyl)-2H-tetrazole; 5-[1 -(2,6-dich!orophenyl)-IH-pyrazol-4-ylI-2-(4-methoxybenzyl)-2H-tetrazole; 5-[1-(2,6-dichlorophenyl)-I IT-pyrazol-4-y1j-1-(4-rnethoxybenzy1)-2H-tetrazo1e; 5-[1-(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-telrazole; 5-[1 -(3,4-dichlorophenyl)-1II-pyrazol-4-yl]-I -(4-methoxybenzyl)-2H-tetrazole; 5-il -(3,5-dichlorophenyl)-114-pyrazol-4-yI]-2-(4-methoxybenzyl)-211-tetrazole; 5-[1 -(3,5-dichlorophenyl)-III-pyrazol-4-ylj-1 -(4-rneihoxybenzyl)-2H-tetrazole; 5-11 -(2-bromopheny1)-1H-pyrazo1-4-y1j-2-(-rnethoxybenzy-2II-tetrazo1e; 5-11 -(2-brornophenyl)-I I-I-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; -[1 -(3 -bromophenyl)-11 I-pyrazol-4-yfl -2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[1 -(3 -broinophenyl)-1H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazoic; 5-[1-(4-bronwphenyl)-] H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-211-tetrazole; 5-[1-(4-hromophenyl)-1LI-pyrazol-4-yl]-1-(4-rnethoxybeazyl)-211-tetrazole; 5-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-2-(4-rnethoxyhenzyl) -21-1-tetrazole; 5-fl -(4-fiuorophenyI)-H-pyrazol-4-yll-1-(4-mcthoxybenzyl)-2H-tetrazole; 5-[1-(2-fluorophenyl)-IH-pyrazol-4-yl]-2-(4-nwthoxybenzyl)-2R-tetrazole; 5-[1 -(2-fluorophenyl)-1H-pyrazol-4-yl]-1-(4-methoxybenzyl)-2H-tetrazo]e; 5-[1 -(2,3-dimethylphenyl)-IH-pyrazol-4-ylj-2-(4-rnetfoxybenzyl)-2H-tetrazole; 5-[1 -(2,3-dirnethylphenyl)-1 H-pyrazol-4-yfl-1-(4-rncthoxybenzyl)-2H-tetrazole; 5-[1 -(2,4-dirnethylphcnyl)-1I-I-pyrazol-4-yl]-1-(4-methoxybenzyl) -211-tetrazole; 5-[1 -(2,4-dimethylphenyl)-1 H-pyrazoi-4-yl]-I -(4-methoxybenzyl)-2H-tctrazole; 541 -(2,5-dirnethylphenyl)-1H-pyrazol-4-yfl-2-(4-methoxyhenzyl)-2H-tetrazole; 541 -(2,5-dirncthy1phenyt)-H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[1-(2,6-dimethy!phenyl)-1II-pyrazol-4-ylI-2-(4-methoxybenzyl) -2H-tetrazole; 5-[1 -(2.6-dimethylphenyl)-1H-pyrazol-4-ylj-1 -(4-rnethoxybenzyl)-2H-tetrazole; 5-[1 -(1,4-dimethypheny])-I H-pyrazol-4-yI]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[ 1 -(3,4-dimethyiphenyl)-1H-pyrazol-4-yI]-1 -(4-rnethoxybenzyl)-21-I-tetrazole; 5-[1-(3,5-dimethylpheny])-1 H-pyrazol-4-yll-2-(4-mcthoxybenzyl)-2H-tetrazole; 5-[1 -(3,5-dimethylphenyl)-1T1-pyrazol-4-yl]-1-(4-rnethoxybenzyl)-2H-tetrazolc; 5-[1 -(2-ethyiphenyl)-1 I-I-pyrazol-4-yij -2-(4-rnethoxyhenzyl)-2H-tetrazole; 541 -(2-ethy1pheny-I H-pyrazol-4-yl] -1 -(4-methoxybenzyl)-21 1-tetrazole; 5-fl -(4-eihylphenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-te.trazole; 5-[1 -(4-ethyiphenyl)-11 I-pyrazol-4-ylj-I -(4-methoxyhenzyl)-2H-tetrazole; 2-(4-methoxyhenzyl)-5-[I -(4-methoxyphenyl)-1H-pyrazol-4-yfl-211-tetrazole; 2-(4-rnethoxybenzyl)-5-[1 -(4-methoxyphenyl)-IH-pyrazol-4-yl]-2H-tetrazolc; 2-(4-methoxybenzyl)-5-[1 -(2-methylphenyl)-1 1-1-pyrazol-4-yl]-2H-tctrazole; I -(4-methoxybenzyl)-5-[1 -(2-methyiphenyl)-I H-pyrazol-4-yIl-21-I-tetrazole; 2-(4-niethoxybenzyl)-5-[ 1 -(4-methyiphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-methoxybenzyl)-5-[ 1 -(4-methyiphenyl)-I H-pyrazol-4-yll-21I-tetrazole; 5-(5-ehloro-1 -mcthyl-I I-1-pyrazol-4-yl)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-1-(4-rnethoxybenzyl)-2H-tetrazole; 5-(5-chloro-1 -ethyl-] H-pyrazol-4-yI)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(5-chloro-1-ethyl-1H-pyrazol-4-yl)-1-(4-rnethoxybenzyfl-2H-tetrazole; 5-[5-chloro-1 -(2-methv1propy1)-1II-pyrazo1-4-y1-2-(4-methoxybenzy])-2H-tetrazole; 5-[5-chloro-1 -(2-methypropy1)-I H-pyrazol-4-yl]-1 -(4-metboxybenzyl)-2H-tctrazole; -0 -bcnzy1-5-eh1oro-1H-pyrazo1-4-y)-2-(4-methoxybenzy1)-2II-tetrazo1e; 5-(1-benzyl-5-ehloro-1H-pyrazol-4-yl)-1-(4-methoxybenzvl)-2H-tetrazole; 5-(5-chloro-1 -phcnyl-1 H-pyrazo1-4-y)-2-(4-methoxyhenzy)-2i1-tetrazo1e; 5-(5-chloro-1 -phenyl-1II-pyrazol-4-yl)-1-(4-methoxybenzyl)-2H-tetrazole; 5-[5-chloro-1-(2-chlorophenyl)-IH-pyrazol-4-yI]-2-(4-niethoxybcnzyl) -21-I-tetrazole; 5-{5-ch1oro-1-(2-ch1oropheny)-1H-pyrazo1-4-y1]-1-(4-rnethoxyhenzy1) -2H-tetrazole; 5-L5-cliloro-1 -(3-chloropheny])-1 H-pyrazol-4-yl]-2-(4-methoxybenzyl)-21-1-tetrazole; 5-15-ebloro-1 -(3-cblorophenyl)-1H-pyrazol-4-yl]-I-(4-rnethoxybenzyl)-2H-letrazole; 5-[5-ehloro-1 -(4-chlorophenyl)-IH-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-ctiloro-I -(4-ebIoropheny-1 H-pyrazol-4-yl]--1 -(4-methoxybenzyl)-21-1-tetrazole; 5-[5-ehloro-1 -(2,3-dichlorophenyl)-1 II-pyrazol-4-yl]-2-(4-mcthoxybenzyl)-2H-tetrazole; 5-[5-ehloro-1-(2,3-diehlorophenyl)-1II-pyrazol-4-yl]-1 -(4-methoxybenzyl)-21-I-tetrazole; 5-[5-ehloro-1-(2,4-diehlorophenyl)-1J-I-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tctrazole; 5-[5-ehloro-I -(2,4-diehlorophenyl)-1 H-pyrazol-4-yl]-1 -(4-methoxybcnzyl)-2H-tctrazole; 5-[5-ehloro-1 -(2,5-diehlorophenyl)-1 II-pyrazol-4-yll-2-(4-methoxybenzyl)-21-I-tetrazole; 5-[5-ehloro-1 -(2,5-dieliloroplienyl)-1 I-1-pyrazol-4-yl]-1 -(4-methoxybenzyl)-211-tetrazole; 5-[5-ehloro-1-(2,6-diehlorophenyl)-1Ii-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-ielrazole; 5-[5-chloro--1 -(2,6-dichiorophenyl)-1H-pyrazol-4-yl]-i -(4-nicthoxybenzyl)-2H-tetrazole; 5-[5-cffloro-1 -(3,4-diehiorophenyl)-I H-pyrazol-4-yl]-2-(4-methoxyhenzyl)-2H-tetrazole; 5-[5-chloro-1 -(3,4-diehlorophenyl)-1H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-ielrazole; 5-[5-chloro-1 -(3,5-diehlorophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzvl)-21-1-tetrazole; 5-L5-chloro-I -(3,5-dieh[oropheny[)-1 H-pyrazo!-4-y!]-1 -(4-methoxybenzyl)-211-tetrazole; 5-[1 -(2-bromophenyl)-5-chloro-1I-1-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazole; 5-.[1-(2-brornophenyl)-5-chloro-1H-pyrazoL-4-yl]-I -ftmethoxybenzyl)-2H-tetrazole; 5-[1 -(3-brornophenyl)-5-chloro-I H-pyrazol-4-yI]-2-(4-methoxybenzyl)-211-tctrazole; 5-[ 1 -(3-brornophenyl)-5-cffloro-11-I-pyrazol-4-yl]-1-(4-methoxybenzy) -2IT-tetrazoIe; 5-[1 -(4-brornophenyl)-5-chloro-IH-pyrazol-4-yl]-2-(4-rnethoxybenzyl) -2H-tetrazole; 5-[I -(4-brornophenyl)-5-chloro-1 H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-211-tetrazole; 5-[5-ehioro-1-(4-fluorophenyl)-1H-pyrazoi-4-ylj-2-(4-rnelhoxybenzyl) -2H-tetrazo!e; 5-[5-ehloro-I -(4-fluorophenyl)-1H-pyrazol-4-yfl-2-(4-methoxybenzyl)-211-tetrazole; 5-[5-chloro-I -(2-fluorophenyl)-1II-pyrazol-4-yfl-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2-fluorophenyl)-I 1-T-py azol-4-yI]-I -(4-methoxybenzyl)-211-tetrazole; 5-[3-ehloro-1-(2,3-dimethylphenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazole; 5-[5-ehloro-1-(2,3-diniethylphenyl)-IH-pyrazol-4-yl]-I -(4-methoxybenzyl)-211-tetrazole; 5-[5-ehloro-I -(2,4-dimethyiphenyl)-1II-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(2,4-dimethyiphenyl)-iI-I-pyrazol-4-yTj-1 -(4-methoxyhenzyl)-21I-tctrazole; S 5-L5-ehloro-I -(2,5-dimethylphenyl)-1H-pyrazol-4-yij-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-cbloro-i-(2,5-dimethylphenyl)-1H-pyrazol-4-yi]-i-(4-rnethoxybenzyl) -2H-tetrazole; 5-[5-chloro-1-(2,6-dimethylphenyl)-1 H-pyrazol-4-yl]-2-(4-mcthoxybenzyl)-211-tetrazole; 5-15-chloro-1 -(2,6-dimethyiphenvi)-I H-pyrazol-4-yI j-i -(4-mcthoxybenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(3,4-dirnethy1pheny-iH-pyrazo1-4-y]j-2-(4-methoxybenzyl)-2H-tetrazo1e; 5-[5-chloro-1 -(3,4-dimethylphenyl)-1H-pyrazol-4-ylj-1 -(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-chloro-i -@ .5-dimethylphenyl)-1 1-i-pyrazol-4-yl]-2-(4-methoxybenzyl)-2T-T-tetrazole; 5-{5-ehloro-1 -(3.5-dirnethylphcny-H-pyrazol-4-ylJ-1 -(4-methoxybenzyl)-21-i-tetrazoie; 5-[5-ehloro--(2-ethylphenyl)-1T1-pyrazol-4-yij-2-(4-methoxybenzyl) -2H-tetrazole; 5-[5-chloro-1-(2-ethylphenyl)-1H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-21-i-tetrazole; 5-[5 -ehioro-1 -(4-ethyiphenyl)-1 H-pyrazol-4-ylj-2-(4-niethoxybenzyl)-2T-i-tetrazole; 5-{5-ehloro-1 -(4-ethylphenyl)-iI-I-pvrazol-4-vll-1-(4-methoxvbenzyl)-2H-tetrazole; 5-[5-chloro-I -(4-nwthoxyphenyi)-1 H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-chloro-I -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-i -(4-rnethoxybenzyl)-2H4etrazole; 5-[5-chloro-1 -(2-methyiphenyl)-1 FI-pyrazol-4-ylI-2-(4-methoxybenzy])-2H-tetrazole; 5-5-ch1oro-1-(2-methy1phenyI)-H-pyrazol-4-yl]-1 -(4-rncthoxybcnzyl)-2H-tetrazok; 5-[5-ehloro-I -(4-methyiphenyl)-1H-pyrazol-4-yi]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(4-methyiphenyl)-IH-pyrazol-4-ylj-1 -(4-methoxyhenzyl)-2H-tetrazole; 5-(5-bromo-1-methyl-1H-pyrazot-4-yI)-2-(4-methoxyhenzyl)-21-I-tetrazole; 5-(5-bromo-1 -methyl-i H-pyrazol -4-yl)-l -(4-rnethoxyhenzyl)-21 1-tetrazole; 5-(5-bromo-I -ethyl-I 1-1-pyrazol-4-yl)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(3-brorno-i -ethyl-1H-pyrazol-4-yl)-1 -(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-broino-1 -(2-methyipropyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-211-tetrazole; 5-[5-brorno-1 -(2-methylpropyl)-1 II-pyrazol-4-yl]-i-(4-methoxybenzyl)-2F1-tetrazole; 5-U -benzyl-5-bromo-1H-pyrazol-4-yl)-2-(4-rnethoxyhenzyl)-21-I-tetrazole; 5-( I -benzyl-5-bromo-1 T-1-pyrazol-4-yi)-i-(4-rnethoxybenzyl)-2H-tetrazole; 5-(5-bromo-1 -phenyl-1H-pyrazol-4-yl)-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-(5-bromo-I -phenyl-I H-pyrazol-4-yl)-i-(4-mcthoxybenzyl)-2H-tetrazole; 5-[5-bromo-i-(2-ehlorophenyl)-111-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazole; 5-[5-bromo-l -(2-elilorophenyl)-IH-pyrazol-4-yl]-1-(4-methoxybenzyl)-211-tetrazole; 5-[5-bromo-1 -(3-clilorophenyl)-1 II-pyrazo1-4-ylj-2-(4-methoxybery1)-2H-tetrazo1e; 5-[5-bromo-1-(3-chlorophenyl)-1 H-pyrazol-4-yI]-1-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-chlorophenyl)-I 1-T-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-chlorophenyl)-1H-pyrazol-4-yl]-1-(4-rncthoxyhenzyl)-211-tetrazole; 5-[5-bromo-1 -(2,3-dichlorophenyl)-I T-T-pyrazol-4-ylj-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-bromo-I -(2,3-dichiorophenyl)-1H-pyrazol-4-ylj-] -(4-mcthoxyhenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,4-dichlorophcnyl)-I H-pyrazol-4-yl]-2-(4-methoxybenzy])-2H-tetrazole; 5-[5-bromo-1-(2,4-dichlorophenyl)-1 H-pyrazol-4-yll-1-(4-methoxybenzyl)-2H-tctrazole; 5-[5-brorno-1-(2,5-dichlorophcnyl)-Ifl-pyrazol-4-yl]-2-(4-rnethoxybenzyl) -2F1-tetrazole; 5-[5-brorno-I -(25-dichlorophenyl)-1H-pyrazol-4-ylj-1-(4-mcthoxybenzyl)-211-tetrazole; 5-[5-bromo-1 -(2,6-dich1oropheny1)-1H-pyrazo1-4-y1]-2-methoxybenzy1)-2H-Letrazo1e; 5-[5-bromo-1 -( ,6-dichlorophenyl)-I-1-pyrazol-4-yl]-1 -(4-niethoxybenzyl)-2H-tetrazole; 5-[5-bromo-I -(3,4-dich!orophdny1)-1H-pyrazo1-4-y1-2-(4-rnethoxybenzyl)-2H-tctrazo1e; 5-[5-hrorno-1 -(3,4-dichiorophenyl)-1H-pyrazol-4-yIj-I -(4-methoxybenzyl)-211-tetrazole; is 5-[5-broino-1-(3,5-dichloroplienyl)-I H-pyrazo!-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo--(3,5-dichlorophcnyl)-1FI-pyrazol-4-yl]-1-(4-methoxyhenzyl) -21i1-tetrazole; 5-[5-bromo-l -(2-hromophenyl)-l H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-brorno-1-(2-bromophcnyl)-I H-pyrazol-4-yl]-I-(4-rnethoxybenzyl)-2H-tctrazole; 5-[5-bromo-I -(3-hromophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-broino-1 -(3-brornophenyl)-H-pyrazol-4-yI]-1-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(4-bromophenyl)-1 II-pyrazo1-4-y1]-2-(4-niethoxybenzy-2H-tetrazo1e; 5-[5-brorno-I -(4-bromophenyl)-1H-pyrazol-4-yl]-1 -(4-niethoxyhenzyl)-211-tetrazole; 5-[5-bromo-1 -(4-fluorophenyl)-I H-pyrazol-4-yI]-2-(4-methoxybenzyl)-2H-telrazole; 3-{5-bromo-1 -(4-fluorophcnyl)-I fl-pyrazol-4-yl]-1-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-I -(2-fiuorophcnyl)-1I-I-pyrazol-4-yl]-2-(4-rncthoxybenzyl)-2H-tetrazole; 5-[5 -bromo-1 -(2-fluorophenyl)-1H-pyrazol -4-yI]-I -(4-mcthoxybenzyl)-2H-letrazole; 5-[5-bromo-1 -(2,3-dimethylphenyl)-I H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazo!e; 5-[5-hromo-1 -(2,3-dimethylphcnyl)-1H-pyrazol-4-yl]-l -(4-methoxybenzyl)-2H-tctrazole; 5-[5-bromo-1 -(2,4-dirnethylphenyl)-I H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-I -(2,4-dimcthylphenyl)-1II-pyrazol-4-yI]-I-(4-methoxybenzyl)-2H-tetrazole; 5-{5-brorno-I -(2,5-dimethyiphenyl)-I H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1-(2,5-dirncthylphenyl)-1TI-pyrazol-4-ylj-I -(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,6-dimethylphenyl)-11-1-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2,6-dirnethylphenyl)-1i1-pyrazol-4-ylj-1 -(4-rnethoxybenzyl)-2H-tetrazole; 545-bromo-I -(3,4-dimethy1pheny1) 1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(3,4-dimethylphenyl)-] H-pyrazol-4-y1]-1 -(4-methoxybenzyl)-2H-tctrazole; 5-[5-bromo-l_(3,5-dimethy1pheny1)_1iI-pyrazol-4-y]-2-(4-methoxybenzy1) -2II-tetrazole; 5-[5-brorno-1 -(3 >5-dimethyiphenyl)-I H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(2-ethylpheny])-1 H-pyrazol-4-yl]-2-(4-metboxybenzyl)-2H-tetrazole; 5-L5-bromo-1 -(2-ethylphenyl)-1 I-1-pyrazol-4-ylJ-1 -(4-rnethoxybenzyl)-21-1-lelrazole; 5-[5-bromo-1 -(4-ethylphenyl)-1 Hpyrazol-4-y1]-2-(4-methoxybenzy-2H-tetrazo1e; 5-[5-bromo-I -(4-ethylphenyl)-1H-pyrazol-4-yI]-I -(4-methoxybenzyl)-2H-tetrazole; 5-[5-hromo-1-(4-methoxyphenyl)-I I-1-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-brorno-1 -(4-mcthoxyphenyl)-i I-I-pyrazol-4-ylj-1-(4-methoxybenzyl)-2H-telrazole; 5-j5-bromo-I -(2-rnethylphenyl)-1H-pyrazol-4-yI]-2-(4-methoxybenzyl)-2H-tetrazOle; 5-[5-bromo-1 -(2-methyiphenyl)-I H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(4-rnethy1pheny-iII-pyrazo1-4-y1]-2-(4-rnethoxyhenzyl) -2II-tetrazOle; 5-[5-bromo-1 -(4-methyiphenyl)-1II-pyrazol-4-yi]-I -(4-methoxybenzyl)-2H-tetrazole; 5-(5-iodo-1 -methyl-i H-pyrazol-4-yl)-2-(4-methoxybenzyl)-2F1-tetrazole; 5-(5-iodo-1-methyl-1H-pyrazol-4-yl)-I -(4-methoxybenzy-2H-tetrazo1e; 5-(I-ethyl-5-iodo-1H-pyrazo1-4-yl)-2-(4-methoxybenzy-2H-tetrazole; 5-(l -ethyl-5-iodo-1H-pyrazol-4-yl)-1-(4-metlioxybenzyl)-2H-tetrazole; 5-[5-iodo-1 -(2-methylpropyl)-1IT-pyrazoi-4-y1-2-(4-methoxybenzy1)-2F1-tetrazoIe; 5-[5-iodo-1 -(2-methylpropyl)-1H-pyrazol-4-yI]-1 -(4-methoxybenzy-2H-tctrazo1e; 541 _henzyl-5_iodo-1H-pyrazol-4-y[)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(1-benzyl-5-iodo-I H-pyrazol-4-yl)-1-(4-rnethoxybcnzyl)-211-tetrazole; 5-(5-iodo-1-phenyl-Ii1-pyrazol-4-yl)-2-(4-mcthoxyhenzyl)-2H-telrazOle; 5-(5-iodo-1-pheny1-1H-pyrazol-4-y-1 -(4-methoxybenzyl)-2H-tetrazole; 5_[1-(2_chlorophenyl)_5-iodo-III-pyrazol-4-ylJ-2-(4-rnethoxybenzyl) -2H-tetrazole; 541 -(2-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-I -(4-methoxybenzyl)-2H-tetrazole; 5-[I (3-ch1oropheny1)-5-iodo-1II-pyrazo1-4-yl]-2-(4-mcthoxybenZy1)-2H-tetraZO!e 5-[1 -(3-chlorophenyl)-5-iodo-11-1-pyrazol-4-yl]-1 -(4-methoxybenzyl)-211-tetrazoie; 5-[1 -(4-chlorophenyl)-5-iodo-I H-pyrazol-4-yi-1-(4-methoxybenzy1)-2FI-tetrazo1e; 5-[1 -(2,3dic1i1orophenyl)_5_iodo-1TI-pyrazo1-4-y1]-2-(4-rnCthOxybenZy1) -2H-tetraZOie; 5_[1-(2,3-dichlorophenyl)-5-iodo-IH_pyrazol-4-yll-1-(4-methoxybenzyl) -2H-tetrazole; 5_[1_(2,4-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2-(4-rnethoxybenzyl) -21H1-tetrazole; 5_[1_(2,4-diehiorophenyl)-5-iodo-1H-pyrazol-4-yI]-1-(4-rnethoxybeflzyl) -2H-tCtflZOle; 5-[1 -(2,5-dichlorophcnyl)-5-iodo-1I-I-pyrazol-4-yl]-2-(4-methoxybenzyl) -211-tetrazole; 5-[1-(2,5-dichlorophenyl)-3-iodo-I l-I-pyrazol-4-y!]-1-(4-methoxybenzyl)-211-tetrazole; 5-41 -(2,6-dichlorophcnyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-rnethoxybenzyl) -2H-tetrazole; 5-[1-(2,6-dichlorophenyl)-5-iodo-I H-pyrazol-4-yl]-1-(4-methoxybenzyl)-211-tetrazole; 5-[i -(3,4-dichlorophcnyl)-5-iodo-IFI-pyrazol-4-yl]-2-(4-rnethoxybenzyl) -2H-tetrazole; 5-[1 -(3,4-dichlorophenyl)-5-iodo-1H-pyrazol-4-yIj-1 -(4-rncthoxybenzyl)-211-tetrazole; 5-[1-(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tctrazole; 5-[1-(3,5-diehlorophenyl)-5-iodo-1H-pyrazol-4-yI]-1 -(4-methoxybenzyl)-2H-teirazole; 5-[1 -(2-brornophenvl)-5-iodo-I I-I-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazo]c; 5-[1 -(2-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-1-(4-rnethoxyhcnzyl) -2H-tetrazole; 5-[1-(3-bromophenyl)-5-iodo-1H-pyrazo]-4-yIJ-2-(4-methoxybenzyl) -2H-teirazole; 5-41 -(3-brornophcnyl)-5-iodo-1 1J-pyrazol-4-ylI-1 -(4-methnxybenzyl)-2H-tetrazole; 5_L1-(4_bromoihenyI)_5_iodo_1II-pyrazo1-4-y1]-2_(4-methoxybe11zy1) -2R-tetro1e; 5-[ -(4-bromophcnyl)-5-iodo-1H-pyrazol-4-yI]-I -(4-methoxybenzyl)-21-I-tetrazole; 5-[1 -(4-fluorophenyl)-5-iodo-1 I-I-pyrazol-4-yI]-2-(4-mcthoxybenzyl)-2H-letrazole; 5-[1-(4-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-(4-rnethoxybenzyl) -21J-tctrazole; 5-[l-(2-fluorophenyl)-5-iodo-1H-pyrazol-4-yI]-2-(4-methoxybenzyl) -211-tetrazole; 5-[l -(2-fluoroplienyl)-5-iodo-1II-pyrazol-4-ylJ-l -(4-rnethoxybenzyl)-21-I-tctrazolc; 5-[1-(2,3-dimethylphenyl)-5-iodo-1 H-pyrazol-4-yI]-2-(4-methoxybeazyl)-2F1-tetrazole; 5-[1 -(2,3-dimeihylphenyl)-5-iodo-1H-pyrazol-4-yli-1-(4-nieihoxyhenzyl) -2F1-tctrazole; 5L1-(2,4-dirnethy1phcnyl)-5-iodo-1II-pyrazo1-4-yU-2-(4-rnethoxyhc1ny1) -2H-tetrazo1e; 5-LI -(2,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-i -(4-methoxybenzyl)-2H-telrazole; 5-[1 -(2,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-yI]-2-(4-rnethoxybenzyl) -2H-tetrazOlC; 5-[1 -(2,5-dirnethylphenyl)-5-iodo-1II-pyrazol-4-yl]-1-(4-rnethoxybenzyl) -21T-tetrazole; 5-LI -(2,6-dimethylphenyl)-5-iodo-1H-pyrazol-4-ylj-2-(4-niethoxybenzyl) -2H-telrazole; 5-fl -(2,6-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1-(4-methoxybenzyl) -2H-tetrazOle; 5-fl -(3,4-dimethylphenyl)-5-iodo-1 T-1-pyrazol-4-yll-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-Li -(3,4-dimethylphenyl)-5-iodo-1I-1-pyrazoi-4-yl]-i -(4-rncthoxybenzyl)-211-tetrazole; 5-L1_(3,5-dimethylpheny])-5-iodo-i H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazolc; 5-fl -(15-dirnethylphcnyfl-5-iodo-1II-pyrazol-4-yi]-i -(4-rnethoxybcnzyl)-2H4elrazole; 5-[1 -(2-cthylphenyl)-5-iodo-1H-pyrazol-4-yI]-2-(4-rncthoxybenzyl) -211-tetrazoie; 5_[1-(2-ethylphenyl)-5-iodo-1R-pyrazol-4-yl]-1-(4-methoxybenzyl) -2H-tctrazole; 5-Ll -(4-cthylphenyl)-5-iodo-IH-pyrazol-4-yI]-2-(4-methoxybenzyl) -211-tetrazole; 5-fl -(4-ethylphenyl)-5-iodo-1H-pyrazol-4-yfl-1-(4-methoxybenzyl)-2H-tetrazolc; 5-[5-ioclo-1 -(4-rnethoxypheny1)-1H-pyrazo1-4-y1-2-(4-methoxybenzy1)-2H-teLrazoIe; 5-[5-iodo-1-(4-rnethoxyphenyl)-IH-pyrazol-4-yl]-1-(4-methoxybenzyl) -2H-tetrazole; 5-[5-iodo-I -(2-methyiphenyl)-I fl-pyrazol-4-yfl-2-(4-rnetlioxybenzyl)-2H-tetrazole; 5-15-iodo-1-(2-metliylphenyl)-1M-pyrazol-4-yli-1- (4-inethoxybenzyO-2H-tetrazole; 5-[5-iodo-I -(4-methylphenyl)-I H-pyrazoI-4-y-2-(4-methoxybenzy1)-2H-tetrazo1e; 5-[5-iodo-1 -(4-methyiphenyl)-1H-pyrazol-4-yl]-1 -(4-rnelhoxybenzyl)-2H-tetrazole; 2-(3 rnethy1benzyI)-5-( I -methyl-I H -pyrazol-4-yl)-21-T-tetrazole; 1-(3-methylbenzyl)-5-(l -rnethyl-1H-pyrazol-4-yl)-2H-tetrazole; 5-(1-ethyl-1H-pyrazol-4-yl)-2-(3-methylbenzyl)-21-1-tetrazole; 5-(1-ethyl-1II-pyrazol-4-yl)-1-(3-rnethylbenzyl)-21-I-tetrazole; 2-(3-methylbenzyl)-5-[l -(2-methylpropvl)-11-1-pyrazol-4-yIJ-2H-tetrazole; 1 -(3-methylbenzyl)-5-[I -(2-methyipropyl)-I H-pyrazol-4-yll-2H-tetrazole; 5-( 1 -henzy i-I H-pyrazol-4-yl)-2-(3 -methylbenzyl)-2H-tetrazole; 5-(l-benzyl-1H-pyraz.ol-4-yl)-1--(3-methylbenzyl)-2H-tetrazole; is 2-(3 -methylbenzy])-5-( 1 -phenyl-I H-pyrazol-4-yl)-2H-tctrazole; 1-(3-rnethylbcnzyl)-5-(1 -phenyl-1II-pyrazol-4-yl)-2H-tetrazole; 5-[l-(2-chlorophenyl)-1II-pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[1-(2-chlorophenyl)-I H-pyrazol-4-yI -1 -(3-methylbenzyl)-2H-tetrazole; 5-fl -(3-chlorophenyl)-1H-pyrazol-4-yI]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[1 -(3-ehiorophenyl)-I H-pyrazol-4-yI]-I -(3-rnethylbenzyl)-2H-tetrazole; 541 -(4-ehlorophenyl)-I T-l-pyrazol-4--yll -2-(3-methylbenzyl)-2H-tetrazole; 5-{1 -(4-eh1oropheny1)-1H-pyrazo1-4y1]-1-(3-rnethy1benzyI)-2H-tetrazole; 5-Il -(2,3-dichiorophenyl)-1H-pyrazol-4-yI]-2-(3-methylbenzyl)-2F1-tetrazole; 5-i -(2,3-dichlorophenyl)-1 1-T-pyrazol-4-yll-1 -(3-methylbenzyl)-2F1-tetrazole; 5-[1 -(14-dichlorophenyl)-IH-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetraz.ole; 5-[1 -(2.4-dichlorophenyl)-1I-I-pyrazol-4-ylj-1 -(3-rnethylbenzyl)-2H-tetrazole; 541 -(2,5-dichiorophenyl)-I H-pyrazol-4-yIj-2-(3-rnethylbcnzyl)-2H-tetrazole; 5-El -(2,5-dichlorophenyl)-1 H-pyrazol-4-yI]-1 -(3 -methylhenzyl)-2H-tetrazole; 5-11 -(2,6-dichiorophenyl)-I H-pyrazol-4-yl]-2-(3-methylbenzyl)-21T-tetrazole; 5-[1 -(2,6-diehlorophenyl)-1IT-pyrazol-4-yl]-1-(3-methylbenvyI)-2H-tetrazolc; 5-[I -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(3-methylbenzyl)-21-T-tetrazole; 5-[1 -(3,4-dich]orophenyl)-I H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-teftazo Ic; 5-fl -(3,5-dichlorophenyl)-IH-pyrazol-4-ylj-2-(3-methylbenzyl)-2H-tetrazole; 5-11 -(3,5-dichiorophenyl)-I H-pyrazol-4-yll-l -(3-methylbenzyl)-2H-tetrazole; 5-[1 -(2-broniophenyl)-1II-pyrazol-4-ylJ-2-(3-methylbenzyl)-2H-ietrazole; 5-[1 -(2-brornophenyl)-1 H-pyrazol-4-yl]-1 -(3-methy!benzyl)-2H-tetrazole; 5-[T -(3-hromophenyl)-1 II-pyrazol-4-yli-2-(3-rnethylbenzyl)-21-I-tetrazole; 5-[1-(3-brornophenyl)-1I-I-pyrazol-4-yl]-1-(3-rnethylbenzyl)-2H-tetrazole; 5-[1 -(4-bromophenyl)-I 1-I-pyrazol-4-yll -2-(3-methylbenzyl)-211-tetrazole; 5-[1-(4-bromophenyl)-11-I-pyrazol-4-yl]-1-(3-rnethylbenzyl)-2H-tetrazole; 5-[1 -(4-fluorophenyl)-II I-pyrazol-4-ylj-2-(3 -methylbenzyl)-21 1-tetrazole; 5-[1-(4-iluorophenyi)-I H-pyrazcil-4-yl]-1 -(3-methylhenzyl)-2H-tetrazole: 5-fl -(-fluorophenyl)-IH-pyrazol-4-vfl-2-(3-methylbenzyl)-211-tetrazole; 5-[I -(2-fluorophenyl)-1 H-pyrazol-4-yl]-1-(3-rnethylbenzyl)-21-I-tetrazole; 5-[I-(2,3-dimethylphenyl)-1H-pyrazol-4-ylj-2-(3-methyibcnzyl) -2H-tetrazole; 5-fl -(2,3-dirnethylpheny-I-1-pyrazo!-4-yI]-1 -(3-methythenzyl)-211-tctrazole; -[1 -(2,4-dimethylpheny)-1 H-pyrazol-4-yl]-2-(3 -methylbenzyl)-2H-tetrazole; 5-[1-(2,4-dimetliylphenyl)-1Ii-pyrazol-4-ylj-1-(3-rnethylbenzyl) -21-T-tetrazole; 5-[1-(2,5-dirne1FyIpheny-1 H-pyrazol-4-ylj-2-(3-methylhenzyl)-2H-tetrazolc; 5-[1 -(2,5-dirncthyp1ieny1)-1H-pyrazo1-4-y11-1 -(3-methylbenzyl)-211-tetrazole; 5-[1 -(2,6-dimethylphenyl)-1II-pyrazol-4-ylj-2-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(2,6-dimethyphenyl)-IH-pyrazol-4-yl]-1-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(3,4-dimethylphenyl)-1H-pyrazol-4-yfl-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[1-(3,4-dirnethylphcnyl)-1 H-pyrazol-4-yI]-I -(3-methyihenzy)-2H-tetrazo1e; 541 -(3,5-dirnethylphenyl)-11-I-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(3,5-dimethylphenyl)-1H-pyrazol-4-vl]-1-(3-methvlbenzyl)-21-1-tetrazole; 5-[1 -(2-ethylphenyl)-1H-pyrazol-4-ylj-2-(3-methylbenzyl)-21-1-tetrazole; 5-fl -(2-ethylphenyl)-I I-I-pyrazol-4-yll-1 -(3-methylbenzyl)-2H-tetrazole; 5-fl -(4-ethylphenyl)-1 I1-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[1-(4-ethylphenyl)-1II-pyra2ol-4-yl]-1-(3-rnethylbenzyT)-21-I-tetrazole; 5-fl -(4-methoxyphenyl)-I H-pyrazol-4-yI]-2-(3 -rnethylbenzyl)-2H-tetrazole; 5-[ 1 -(4-methoxyphcnyl)-1H-pyrazol-4-yl]-1-(3-methylbenzyl)-2Tl4etrazole; 2-(3-methylbenzyl)-5-[I -(2-rnethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -(3-methylbenzyl)-5-[1 -(2-methyiphenyl)-1IT-pyrazol-4-yl]-2H-tetrazole; 2-(3-methylbenzyl)-5-[1 -(4-methyiphenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 1-(T-methylbenzyl)-5-[1 -(4-methylphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2-(3-rnethylbenzyl)-2H-tetrazole; 5-(5-ehioro-1-methyl-1 H-pyrazoI-4-yI)--(3-methylhenzyl)-211-tetrazole; 5-(5-c.hloro-1 -ethyl-1H-pyrazol-4-yl)-2-(3-methythenzyl)-2H-tetrazole; 5-(5-choro--ethyh1TI-pyraz&-4-y1)-1(3-niethyIbenzy1)-2LI-tetrazoie; 5.45_ch1oro-1_(2-rnethy1propy1)-1T-T-pyrazo14-y1]-2-(3-methy1benzy1) -2II-tetrazole; 5-[5-chloro-I -(2-methylpropyl)-1H-pyrazol-4-yI]-I -(3-methylbenzyl)-2H-tetrazcde; 5-(1-benzyl-5-chloro-I H-pyrazol-4-yl)-2-(3-rnethylbenzyl)-2H-tetrazole; 5(1_benzy1-5_chIoro-1II-pyrazo1-4-y1)-1-(3-methy1benzy1)-2H-tetrazo1e; 5-(5-chloro-1_phenyl-1H-pyrazol-4-yI)-2-(3-methylbenzyl)-2H-tCtraZOIe 5-(5-chloro-I -pheny1-1H-pyrazo1-4yl)-I -(3-methylbenzyl)-2H4etrazole; 5-[5-chloro-1-(2-chlorophenyl)-I H-pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-1-(2-chtorophcnyl)-IH-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-I _(3_chlorophenyl)-1H-pyrazol-4-yI]-2-(3-methylbenzyl)-2H-tctraZOle; 5-[5-chloro-1 -(3-chiorophenyl)-I H-pyrazol-4-yl]-1 -(3-methylbenzyl)-211-tctrazole; 5-[5-chloro-I -(4-chloropheny!)-1H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-_(4_chlorophenyl)-11I-pyrazol-4-yl]-1-(3-methylbenzyl) -2H-tetrazolc; 5-[5-chloro-1 -(2,3-dichlorophenyl)-1 H-pyrazol-4-yl]-2-(3-rnelby[henzyl)-2H-te(iazole; 5-[5-chloro-1 -(2,3-dichlorophcnyl)-I TI-pyrazol-4-yl]-I -(3-mcthylbenzyl)-2H-ietrazole; 5-[5-chloro-142,4_dichlorophenyl)-1H-pyrazol-4-yI]-2-(3-methylbenzyl) -2H-tCtraZOle 5-15-chloro-1 -(2.4-dichiorophenyl)-111-pyrazol-4-ylj-I -(3-methylbenzyl)-2H-telrazole; 5-15-chloro-1-(2,5-dich!orophenyO-11-I_pyrazo]-4-yl}-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[5ehIoro-l -(2,5-dichlorophenyl)-I H-pyrazo1-4y1]-1-(3-rnethylbenzyI)-2II-te1razoIe; 5-[5-chloro-1 -(2,6-dichlorophcnyl)-1 T-I-pyrazol-4-yl]-2-(3-nicthytbenzyl)-2H-tetrazole; 5-15-chloro-1 -(2,6-diehlorophenyl)-1H-pyrazol-4-yI]-I -(3-methylbenzyl)-2H-tetrazole; 5-15-chloro-I -(3,4-dichiorophenyl)-1H-pyrazo!-4-yll-2-(3-methylbcnzyl)-2H-tetrazole; 5-[5ch!oro1-(3,4-dich1orophenyI)-lTI-pyrazo1-4-y1]-1-(3-methyIheflZy1) -2H-te1raZO1C 5_[5-chloro_1_(3,5_dichlorophenyl)_1H-pyrazol-4-yl]-2- (3-mcthylbenzyO-2H-tCtraZOte 5-[5-chloro-1-(3,5-dichlorophenyl)-1H-pyrazol-4-yl]-1 -(3-rnethylbenzyl)-21-I-tetrazole; 5-[1.(2_brornophcny1)_5_ch1oro-1H-pyrazoI-4-y1I-2-(3-methy1beflzy1) -2H-tctraZo1e; 5-[I -(2-hroniophenyl)-5-chloro-1H-pyrazol-4-yIJ-1 -(3-methy1benzy-2T1-tetrazo1e; 5-[1 -(3-bromophcnyl)-5-chloro-I H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 541 -(3-hromophenyl)-5-chloro-I H-pyTazol-4-yl]-I -(3-mcthylbenzyl)-2H-tetrazole; 5-[1 (4-bromophenyI)-5-ch1oro-1H-pyrazo]-4-yI]-2-(3-methylbenzyD-2H-tCtraZO1e 541 -(4-hromophenyl)-5-chloro-I I-1_pyrazol-4-yl]-1-(3-rncthylhenzyl)-2H-tetrazo!e; 5-[5-chloro-1 -(4-fluorophenyl)-1 H-pyrazol-4-yl]-2-(3 -methylbenzyl)-21-1-tctrazole; 5-[5-chloro-I -(4-fluorophenyl)-1H-pyrazo!-4-yl]-1-(3-rnethylbcnzyl)-2H-tetrazole; 5-[5-chloro-I -(2-fluorophenyl)-I H-pyrazol-4-yll-2-(3-methylbenzyl)-211-tetrazole; 5-[5-chloro-1 -(2-fluorophenyl)-1H-pyrazol-4-ylj-1 -(3-rnethylbenzyl)-2H-tetrazoie; 5-[5-chloro-1-(2,3-dimethylphenyl)-11i-pyrazol-4-yi]-2-(3-mcthylbenzyl) -21-I-tetrazole; 5-[5-ehloro-l-(2,3-dimethylphenyl)-1II-pyrazol-4-yl]-1-(3-rnethylhenzyl) -21-T-tetrazole; 5-[5-chloro-I -(2,4-dirnetliylphenyl)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-ehloro-1-(2.4-dirncthylphenyl)-1 H-pyrazol-4-yl]-l -@ -methylbenzyl)-211-tetrazole; 5-[5-ehloro-1-(2,5-dimethylphenyl)-1 H-pyrazol-4-yI]-2-(3-metFylbenzyl)-2H-tetrazole; 5-[5-ehioro-1-(2,5-dirnethylphenyl)-1I1-pyrazol-4-yl]-1-(3-methylbenzyl) -2H-tetrazole; 5-15-chloro-l-(2,6-dimethylphenyl)-J 1-T-pyrazoi-4-yIj-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-ehloro-l-(2,6-dinicthy1pheny1)-H-pyrazol-4-yfl-1 -(3-methylbenzyl)-211-tetrazole; 5-[5-chloro-l-(3,4-dimethylphenyl)-l T-T-pyrazol-4-yi]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(3,4-dimethy1pheny-1H-pyrazo1-4-y1]-I -(3-rnethylbenzyl)-2H-tetrazole; 5-[3-chloro-1 -(3,5-dirnelliylphenyl)-1I-l-pyrazol-4-vl]-2-(3-rnethylbenzvl) -2H-tetrazole; 5-[5-chloro-1-(3,5-dimcthylphenyl)-I I-1-pyrazol-4-yli-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-ch!oro-1 -(2-ethylpheny1)-1I{-pyrazo1-4-y1]-2-(3-rnethylbenzy1)-2Htetrazo1e; 5-[5-ehloro-l -(2-ethylphenyi)-IH-pyrazol-4-yl]-1 -(3-methylhenzyl)-211-tetrazole; 5-5-c.hIoro-I -(4-ethyIpheny-lH-pyrazo1-4-y11-2-(3-methy1benzy1)-2H-tetrazo1e; 5-[5-ehloro-1-(4-ethylphenyl)-I T1-pyruzol-4-yI]-l -(3-methylbenzyl)-2H-tetrazole; 5-[5-ehloro-1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-2-(3-rnetliylbenzyl) -211-tetrazole; 5-[5-ehloro-I -(4-rnethoxyphenyi)-1H-pyrazol-4-yl]-1-(3-methylbenzyl)-2H-tetrazo!e; 5-[5-chloro-1-(2-methylphenyl)-1II-pyrazol-4-ylj-2-(3-rnethylbenzyl) -21-T-tetrazole; 5-[5-ciiloro-1-(2-rnethylphenyl)-I H-pyrazol-4-yfl-1-(3-methylbenzyl)-211-tetrazole; 5-[5-chloro-1 -(4-methylphenyl)-I H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-methylphenyl)-1II-pyrazol-4-ylj-1-(3-methylbenzyl)-2H-tetrazole; 5-(5-bromo-1 -methyl-lII-pyrazol-4-yl)-2-(3-methylbenzyl)-2H-tctrazole; 5-(5-bromo-1 -methyl-1H-pyrazol-4-yl)-1 -(3-n-iethylbenzyl)-2H-tetrazole; 5-(5 -bromo-1-ethyl-i li-pyrazol -4-yI)-2-(3 -methylbenzyl)-21 1-tetrazole; 5-(5-hromo-l -ethyl-1I-1-pyrazol-4-yl)-l -(3-rnelhylbenzyl)-2H-tetrazole; 5-[S-brorno-l-(2-rnethylpropyl)-1Ii-pyrazol-4-yl]-2-(3-methyibenzyl) -2H-letrazole; 5-[5-broino-1-(2-methylpropyl)-1H-pyrazol-4-ylj-1 -(3-methylhenzyl)-211-tetrazolc; 5-( 1 -benzyl-5-brorno-I H -pyrazol-4-yl)-2-(3 -methylbenzyl)-2H-tetrazole; 5-(1 -benzyl-5-bromo-1T-I-pyrazol-4-yl)-1-(3-methylbenzyl)-2H-tetrazole; 5-(5-bromo-1 -phenyl-iH-pyrazol-4-yI)-2-(3-niethylbenzyl)-2H-tetrazole; 5-(5 -brorno-I -phenyl-1 H-pyrazol-4-yi)-1 -(3-methyibenzyl)-21-I-tetrazole; 5-[5-bromo-1 -(2-chlorophenyl)-1 H-pyrazo1-4-y11-2-(3-metliy1benzy1)-2H-tetrazoe; 5-[5-brorno-1 -(2-chlorophenyl)-I H-pyravo!-4-yl]-1 -(3-rnethy1benzy)-2H-tetrazo1e; 5-[5-bromo-1 -(3-ch1oropheny1)-111-pyrazo1-4-y11-2-(3-methy1benzy)-2H-tetrazo1e; 5-[5-bromo-1 -(3-chlorophenyl)-I H-pyrazoT-4-ylJ-I -(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-chlorophenyl)-IT-T-pyrazol-4-yll-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1-(4-chlorophenyl)-IH-pyrazol-4-ylj-1-(3-methylbenzy!) -2H-tctrazole; 5-[5-brorno-1-(2,3-dichlorophenyl)-1 H-pyrazol-4-yI]-2-(3-methylbenzyl)-2ll4etrazole; 5-[5-bromo-1-(2.3-clichlorophenyl)-1H-pyrazol-4-ylj-I -(3-rnethylbenzyi)-2H-tetrazole; 5-[5-bromo-1 -(2,4-dichiorophenyl)-1 H-pyrazo!-4-yL]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2.4-dichlorophenyl)-1H-pyrazol-4-yl]-1-(3-niethylbenzyl)-2H-tetrazole; 5-15-bromo-1-(2,5-dichlorophenyl)-1H-pyrazol-4-ylj-2-(3-mcthylbenzyl) -2H-tetrazole; 5-[5-bromo-1 -(2,5-dichiorophenyl)-1 H-pyrazol-4-y!]-1 -(3-methylbenzyl)-2H-tetrazole; 5-15-brorno-1 -(2,6-dichlorophenyl)-1 1-T-pyrazol-4-yfl-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-hrorno-1 -(,6-dich1oropheny1)-1II-pyrazo1-4-y1j-1-(3-rnethyIhenzy-2H-tctrazo1c; 5-[5-bromo-1 -(3,4-dichiorophenyl)-I H-pyrazoI-4-y1]-2-(-mcthy1benzy1)-2ll-tetrazo1e; 5-[5-bromo-1 -(3.4-dieh1orophcny-1H-pyrazo1-4-y1-1-(3-methy1benzy1)-2H-tetrazo1e; 5-[5-hromo-1 -(3,5-dichlorophenyl)-1 FI-pyTazol-4-y1]-2-(3-rnethylhenzyl)-2H-tetrazole; 5-[5-bromo-1 -(3,5-dichlorophcriyl)-1H-pyrazol-4-yl]-1-(3-methylbenzyl)-2H-tctrazole; 5-[5-brorno-1 -(2-bromophenyl)-1II-pvrazol-4-y1]-2-(3-methylbcnzyl)-2H-tetrazole; 5-[5-hromo-1 -(2-bromophenyl)-1H-pyrazol-4-yl]-I -(3-niethylbenzyl)-2H-tetravole; 5-15-bromo-1-(3-brornophenyl)-J H-pyrazol-4-yI]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(3-hromophenyl)-1II-pyrazol-4-yl]-1-(3-methylbenzyl)-2H-tetrazole; 5-[5-hromo-1-(4-bromophenyl)-IH-pyrazol-4-ylj-2-(3-methy!benzyl) -211-tetrazole; 5-[5-bromo-1 -(4-brornophenyl)-I H-pyrazol-4-yI]-1 -(3-methylbenzyl)-2H-teftazole; 5-[5-bromo-1 -(4-fluorophenyl)-I H-pyrazol-4-yll-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-brorno-1 -(4-fluorophenyl)-1H-pyrazol-4-yl]-1 -(3-rnethylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-fluorophenyl)-1H-pyrazol-4-yl]-2-(3-methylbcnzyl)-21-I-tetrazole; 5-{5-brorno-1-(2-fluorophcnyl)-IH-pyrazol-4-yl]-1 -(3-rnethylhenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,3-dimethyiphenyl)-I 11-pyrazol-4-yl]-2-(1-methylbenzyl)-211-tetrazole; 5-[5-bromo-I -(2,3-dimethylphcnyl)-1H-pyrazol-4-yll-1-(3-methylhenzyl)-2H-tetrazole; 5-[5-bromo-1-(2,4-dimethylphenyl)-1H-pyrazol-4-yI]-2-(-methylbenzyl) -2H-tetrazole; 5-[5-brorno-I -(2,4-dimethyiphenyl)-IH-pyrazol-4-yl]-1 -(3-methythenzyl)-2H-tetrazole; 5-[5-bromo-I -(2,5-dimethyiphenyl)-11-I-pyrazol-4-yl]-2-(3 -rnethylhenzyl)-2H-tetrazole; 5-[5-bromo-1-(2.5-dimethylphenyl)-IH-pvrazol-4-yI]-l -(3-methylbenzyl)-211-tetrazole; 5-[5-brorno-1 -(2,6-dirnethylphenyl)-1H-pyrazol-4-yl]-2-(3-mcthylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,6-dimethylphenyl)-1H-pyrazol-4-yl]--1-(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(3,4-dirncthylphcnyl)-1H-pyrazol-4-yl]-2-(3-mcthylbenzyl)-2H-tetrazole; 5-15-bromo-1 -(3,4-dimethylphenyl)-1II-pyrazol-4-yl]-1 -(3-methylbenzyl)-21-I-tetrazole; 5-[5-hromo-1 -(3,5-dirnethylphenyl)-1 H-pyrazol-4-yl]-2-(3-methylbcnzyl)-2H-tetrazole; 5-[5-hrono-1 -(3,5-dimethylphenyl)-1II-pyrazol-4-yll-1-(3-rnethylbenzyl)-21I-tetrazole; 5-[5-brorno-1 -(2-ethylphenyl)-1H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2-ethyiphenyl)-1H-pyrazo1-4-y1j-1-(3-rneihy1benzy1)-2H-tetrazo1e; 5-[5-brorno-1-(-ethy1pheny1)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[5-bromo-I -(4-ethy!phenyl)-1 H-pyrazol-4-yI]-1 -(3-methvlhenzyl)-21-1-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-1II-pyrazol-4-yl]-2-(3-methylbenzyl)-21-I-tetrazole; 5-[5-brorno-1 -(4-methoxyphenyl)-1H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-methyIphcny-EI-pyrazol-4-yl]-2-(3-niethylhenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-methylphenyl)-1 H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-methylphenyl)-IH-pyrazol-4-ylj-2-(3-rnethylbenzyl)-2H-tetrazok; 5-[5-brorno-1 -(4-methylpheny-1H-pyrazo1-4-yI]-1 -(3-rncthylbcnzyl)-2H-tctrazolc; 5-(5-iodo-1-methyl-1H-pyrazol-4-yl)-2-(3-methylbenzyl)-21-I-tetrazole; 5-(5-iodo-1-methyl-11-1-pyrazol-4-yI)-1-C-med ylbenzyl)-2H-tetrazolc; 5-U -ethyl-5-iodo-1II-pyrazol-4-yl)-2-(3-methylbenzyl)-21-I-tetrazole; 5-(1 -eihyl-5-iodo-1 H-pyrazol-4-yl)-I -(3-rnethylbenzyl)-2H-tetrazole; 5-[5-iodo-1-(2-rnethylpropyl)-1H-pyrazol-4-yi]-2-(3-mcthyfficnzyl) -21-1-tetrazole; 5-[5-iodo-I -(2-methyipropyl)-1II-pyrazol-4-yl]-I -(3-rnethylbenzyl)-21I-tetrazole; 5-(1-benzyl-5-iodo-1H-pyrazol-4-yl)-2-(3-rnethylbenzyl)-2H-tetrazole; 5-( 1 -benzyl-5-iodo-1 H-pyrazol-4-yl)-1 -(3 -methyl benzyl)-2H-tetrazole; 5-(5-iodo-1 -phenyl-1 H-pyrazol-4-y-2-(3-methy1benzy1)-2II-tetrazo1e; 5-(5-iodo-1 -phenyl-1 H-pyrazol-4-yl)-1 -(3 -methy1benzy1)-2Htetrazo1e; 5-[1 -(2-ehlorophenyl)-5-iodo-1H-pyrazol-4-ylj-2-(3-rnethylbenzyE) -21-1-tetrazole; 5-Fl -(2-chlorophcnyl)-5-iodo-1II-pyrazol-4-yl]-1-(3-methylbenzyl) -2H-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-IH-pyrazol-4-yl]-1-(3-methylbenzyl) -211-tetrazole; 5-{1 -(4-chlorophenyl)-5-iodo-11-I-pvrazol-4-ylj-2-(3-niethylhenzyl) -2H-tetrazole; 5-[ I -(4-chlorophenyl)-5-iodo-lJiI-pyrazol-4-yl]-1 -(3-methylbenzyl)-211-tetrazole; 5-LI -(2,3-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2-(3-methylbenzyl) -2H-ietrazole; 5-{1-(2,3-dichlorophenyl)-5-iodo-I H-pyrazol-4-yI]-1-(3-mcthylbenzyl)-2H-tetrazole; 5-[1-(2,4-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2-(3-methylbenzyl) -2H-tetrazole; 5-[1-(2,4-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-1 -(3-rncthylbcnzyl)-2H-tetrazole; 5-[1-(2,5-diehlorophenyl)-5-iodo-1H-pyra2ol-4-yl]-2-(3-methylbenzyl) -2H-tetrazole; 5-[1-(2,5-dichlorophenyi)-5-iodo-i H-pyrazol-4-yI]-d -(3-rncthylbcnzyl)-2H-tetrazole; 5-[1 -(2,6-diehlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[1 -(2,6-dichlorophenyl)-5-iodo-IH-pyrazol-4-yI]-1 -(3-methy!benzyl)-21-i-tctrazole; 5-[1 -(3,4-dichlorophenyl)-5-iodo-i H-pyrazol-4-yl]-2-(3-methylhenzyl)-211-tetrazole; 5-{i-(3,4-dicIiloropheny1)-5-iodo-iH-pyrazoI-4-y1]-i-(3-methy]bcnzy) -2M-tctrazo1e; 5-[i-(3,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-methylbenzyl) -211-tetrazole; 5-[1 -(3,5-dichIorophenyl)-5-iodo-1II-pyrazo1-4-y1]-1-(3-methy1benzy1) -2H-Letrao1e; 5-fl -(2-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl)-2} -i-tctrazolc; 5-[1 -(2-brornophenyl)-5-iodo-1H-pyrazol-4-yl]-1 -(3-methylbenzyl)-21-i-tetrazole; 5-[1-(3-broniophcnyl)-5-iodo-1 i-T-pyrazol-4-yll-2-(3-methylbenzyl)-2H-tetrazole; 5-fl -(3-bromophenyl)-5-iodo-1H-pyrazol-4-ylj-1-(3-methylbenzyl)-2H-tctrazole; 5-[1-(4-bromophenyl)-5-iodo-IH-pyrazol-4-yl]-2-(3-nietbylbenzy!) -21-I-tctrazolc; 541 -(4-bromophenyl)-5-iodo-1H-pyrazol-4-yi]-1-(3-methylbenzyl)-211-tetra2oie; 5-[1-(4-fluorophenyl)-5-iodo1ll-pyrazol-4-yl]-2-(3-rnethyibenzyl) -2H-tetrazole; 5-fl -(4-fluorophcnyl)-5-iodo-1H-pvrazol-4-yll-1-(3-rnethylbenzyl)-211-tetrazo] e; 5-[1 -(2-fluorophenyl)-5-iodo-iII-pyrazol-4-yl]-2-(3-rnethylbenzyl) -21-1-tetrazole; 5-[i-(2-fluorophenyl)-5-iodo-I H-pyrazol-4-yt]-1 -(3-methylbcnzyl)-2H-tetrazole; 5-Li -(2.3-dimethylphenyl)-5-iodo-I H-pyrazol-4-yI]-2-(3-methythenzyl)-211-tetrazole; 5-fl -(2,3-dimethy1pheny1)-5-iodo-1H-pyrazoh4-y1j-i-(3-methy1beny1) -2H-tetrazoIe; 5-[i-(2,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2H-tctrazole; 5-[1 -(2,4-dhiethy1p1ieny1)-5-iodo-I H-pyrazol-4-yI]--(3-methyIbenzy1)-2II-tetrazoe; 5-[142,5-dimethylphenyl)-5-iodo-1 i-T-pyrazol-4-yl]-2-(3-methylbenzyi)-2H-tetrazole; 5-[1 -(2,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-yij-1-(3-methylbenzyl) -2H-tetrazole; 5-[1-(2,6-dimethylphenyi)-5-iodo-IH-pyrazol-4-yl]-2-(3-methy!henzy!) -21-I-tetrazole; 5-I) -(2,6-dimethylphenyi)-5-iodo-1II-pyrazol-4-yl]-1-(3-rneilwlbenzyl) -21-i-telrazole; 5-[1 -(3,4-dimethyiphenyl)-5-iodo-l H-pyrazol-4-yl]-2-(3-methylbcnzyl)-2H-tctrazolc; 5-[l -(3,4-dirnethylphenyl)-5-iodo-1H-pyrazoi-4-yi]-1-(3-methylbenzyi) -2H-tetrazole; 5-[i-(3,5-dimethylphenyl)-5-ioJo-iH-pyrazol-4-yl]-2-(3-methylbenzyl) -2H-tctrazo[c; 5-[i-(3.5-dimethylphenyl)-5-ioclo-iH-pyrazol-4-yl]-1 -(3-methylbenzyl)-2I1-tetrazole; 5-[1 -(2-ethylphcnyl)-5-iodo-iH-pyrazol-4-yll-2-(3-rnethylbenzyl)-2H-teirazole; 5-[1 -(2-ethyiphenyl)-5-iodo-I H-pyrazol-4-yI]-I -(3-rncthylbenzyi)-2H-tetrazole; 5-[i-(4-cthylphcnyl)-5-iodo-1H-pyrazol-4-yll-2-(3-methylbenzyl) -2Fi-tetrazole; 5-[i-(4-ethylphenyl)-5-iodo-I H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tctrazole; 5-[5-iodo-1 -(4-rnethoxyphenyi)-1I-I-pyrazol-4-yll-2-(3-methvlbenzyl)-2H-tetrazole; 5-[5-iodo-1-(4-rnethoxyphenyl)-1H-pyrazol-4-ylj-i-(3-methylbenzyl) -2H-tetrazoie; 5-[S-iodo-1-(2-methyphenyl)-T H-pyrazol-4-yi]-2-(3-rnethylbenzyl)-21-i-tetrazole; 5-[5-iodo-1 -(2-rnethylphenyl)-1Ii-pyrazol-4-yl]-1-(3-rnethylbenzyl)-21-i-tetrazole; 5-[5-iodo-i -(4-methylphenyl)-1H-pyrazol-4-ylj-2-(3-methylberizyl)-21T-tetrazole; 5-[5-iodo-1-(4-methylphenyl)-1H-pyrazol-4-ylJ-1-(3-rnethylbe.nzyi) -2H-tetrazole; 5-(1-rnetlM-IH-pyrazol-4-yl)-2-(4-nitrohenzyl)-21-{-tetrazole; 5-(1-methyl-ill-pyrazol-4-yl)-1-(4-nitrobenzyl)-2F1-tetrazole; 5-( I -ethyl-iT I-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(i -ethyl-ii-i-pyrazol-4-yl)--(4-nitrohenzyl)-2H -tetrazole; 5-[1 -(2-methyipropyl)-H-pyrazol-4-yl]-2-(4-nitrobenzyi}-2H-tetrazole; 5-[i -(2-mcthylpropyl)-iIi-pyrazol-4-yi]-i -(4-nitrobenzyl)-2H-tetrazole; 5-(1-benzyl-iFl-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-( I -henzyl-i H-pyrazoi-4-yl)-1-(4-nitrobenzyl)-211-tetrazole; 2-(4-nitrohenzyl)-5-(T-phenyl-l H-pyrazol-4-yI)-2H-tetrazole; i-(4-nitrohenzyl)-5-(I-phenyl-1T-i-pyrazol-4-yl)-211-tetrazole; 5-[1 -(2-ehlorophenyl)-l Ii-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(2-ehlorophenyl)-1H-pyrazol-4-ylj-1-(4-nitrobenzyl)-2H-tetrazole; 5-[l -(3-ehlorophenyl)-I H-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[I -(3-chlorophenyl)-1H-pyrazol-4-yl]-i -(4-nitrobenzy1)-2H-tetrazoe; 5-[i-(4-chlorophenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazole; 5-[ 1 -(4-chiorophenyl)-I H-pyrazol-4-yl]-l -(4-nitrobenzyl)-2H-tetrazole; 5-Li -(2,3-dichiorophenyl)-I T-T-pyrazo1-4-y1-2-(4-nitrobenzyi)-2H-tetrazoie; 5-Li -(2,3-dichloroplienyl)-1II-pyrazoi-4-yi]-l-(4-nitrobenzy])-2H-tetrazole; S-[1 -(2,4-dichlorophenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1-(2,4-dichlorophcnyl)-1H-pyrazol-4-yI]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[i -(2,5-dichIoropheny)-1 H-pyrazol-4-ylJ-2-(4-nitrobenzyi)-2H-tetrazoie; 5-El -(2,5-dichlorophenyi)-1FI-pyrazol-4-yl]-i-(4-nitrobenzyl)-2H-letrazo!e; 5-[1-(2,6-dichlorophenyl)-iH-pyrazol-4-yI]-2-(4-nitrobenzyi)-2H-tetrazole; 5-[l -(2,6-dichlorophenyl)-I-T-pyrazol-4-yl]-i-(4-nitrobenzyl)-2H-tetrazole; -L -(3,4-dichlorophenyl)-ili-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-li -(3.4-diehlorophenyi)-1H-pyrazol-4-yI]-I -(4-nitrohenzyl)-211-tetrazole; 5-fl -(3,5-dichlorophenyl)-II-1-pyrazol-4-yll-2-(4-nitrobenzyl)-21I-tetrazole; 5-[i-(3,5-dichlorophenyl)-iH-pyra2ol-4-yi]-i-(4-niftobenzyl)-2H-tetrazole; 5-[ I -(2-bromophenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobcnzyl)-211-tetrazolc; 5-[i -(2-brornophenyl)-iH-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-Li -(3-brornophenyl)-I H-pyrazol-4-yI]-2-(4-nitrobenzyl)-2H-tetrazole; 5-LT -(3-brornophenyl)-i H-pyrazol-4-yl]-1 -(4-nitrobcnzyl)-2H-tetrazole; 5-Li -(4-bromophenyl)-1 II-pyrazol-4-yl]-2-(4-nitrobenzyi)-2H-tetr'azo]e; 5-[1 -(4-bromophenyl)-1 IT-pyrazol-4-yll-1 -(4-nitrobenzyi)-211-tetrazoie; 5-[1-(4-fluorophenyl)-iH-pyrazol-4-yij-2-(4-nitrobenzyl)-2FI-tetrazole; 5-[1 -(4-fluorophenyl)-1H-pyrazol-4-ylj-1-(4-nitrobenzyl)-2H-tctrazole; 5-[i-(2-fluorophenyF)-1H-pyrazoI-4-y1-2-(4-nitrohenzyI)-2H-tetrazoIe; 5-[1 -(2-fluorophenyl)-1 II-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[i-(2,3-dimethylphenyl)-iH-pyrazol-4-yij-2-(4-nitrobenzyi)-2H-tetrazole; 5-LI -(2,3-dimethylphenyl)-IH-pyrazo!-4-yl]-I -(4-nitrobenzyi)-21I-tetrazole; 5-LI -(2.4-dimethylphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[I-(2,4-dirnethylphenyl)-IH-pyrazol-4-yl]--(4-nitrobenzyl) -21-i-tetrazole; 5-[] -(2,5-dirnethy!phenyl)-Ii-i-pyrazol-4-yll-2-(4-nitrobcnzyl)-2H-tetrazole; 5-fl -(2,5-dimethylphenyi)-ili-pyr'azol-4-y]]-1 -(4-nitrohenzyl)-2H-tetrazole; 5-[i-(2,6-dimethylphenyl)-1 H-pyrazol-4-yI]-2-(4-nitrohcnzyl)-2H-tetrazolc; 5-LI -(2,6-dimethylphenyl)-1H-pyrazol-4-ylJ-1 -(4-nitrobenzyl)-2I 1-tetrazole; 5-Li -(3,4-dimethy1pheny-iII-pyrazo1-4-y1]-2-(4-nitrobenzyI)-2H-tetrazoIe; 5-LI -(3,4-dimethylpheny-IH-pyrazo1-4-v1]-1-(4-nitrobcnzyi)-2H-tetrazo1e; 5-[1 -(3,5-dirnethyiphenyl)-1 H-pyrazol-4-yl]-2-(4-nitrohenzyl)-2T-T-tetrazole; 5-[I -(3,5-dimethylphenyl)-1Ii-pyrazol-4-yfl-1-(4-nitrobenzyl)-2H-tetrazoie; 5-[1 -(2-ethylphenyl)-1H-pyrazol-4-yil-2-(4-nitrobenzyl)-2H-tetrazole; 5-[i -(2-ethyiphenyl)-1 H-pyrazoI-4-yI--(4-nitrobenzyl)-2H-tetrazole; 5-[I -(4-ethylphenyl)-1 II-pyrazoi-4-yi]-2-(4-nitrobenzyl)-2H-tetrazoie; 5-Li -(4-ei1iy1pheny1)-iH-pyrazoi-4-y1]-1-(4nitrobenzyl)-2H-tetrazoIe; 5-[I -(4-methoxyphcnyi)-1II-pyrazoi-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; S-[I -(4-rnethoxyphenyi)-iH-pyrazoi-4-yI]--(4-nitrobenzyl)-2H-tetrazole; 5-f i-(2-rnethylphenyl)-I H-pyrazol-4-yIl-2-(4-nitrobcnzyi)-2H-tetrazole; 5-Li -(2-rnethyiphenyi)-I IT-pyrazol-4-yi]-i -(4-nitrobenzyl)-2H-tetrazole; 5-Li -(4-methyiphenyl)-IH-pyrazol-4-yI]-2-(4-nitrobenzyl)-2H-tetrazolc; 5-LI -(4-rnethylphenyl)-1FI-pyrazol-4-yl]-i -(4-nitrobenzyl)-211-tetrazole; 5-(5-chloro--methyl-i H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-chloro-1-rncthyl-1H-pyrazol-4-yl)-1-(4-nitrohenzyl)-2H-tetrazole; 5-(5-chloro-1 -ethyl-IH-pyrazoi-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-chloro-1-cthyl-1H-pyrazol-4-yl)-1-(4-nitrohenzyl)-2H-tetrazolc; 5-[5-chloro-1 -(2-methyipropyl)-1IT-pyrazol-4-yl].-2-(4-nitrobenzyl)-211-tetrazole; 5-[5-c.hloro-1 -(2-methylpropyl)-H-pyrazol-4-yfl-1 -(4-nitrobenzyl)-2H-tetrazo!e; S-(1-henzyi-S-chloro-11-1-pyrazol-4-vl)-2-(4-nitrohenzyl)-2H-tetrazole; S-(l -bcnzyl-3-chioro-1H-pyrazol-4-y])-1-(4-nitrobenzyl)-2T-T-tctraz&e; 5-(5-chloro-I -phenyl-1 H-pyrazol-4-yI)-2-(4-nitrohenzyl)-2H-tetrazole; 5-(5-chloro-1-phenyl-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1-(2-chlorophenyl)-IH-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazole; 5-15-chioro-1-(2-chlorophenyl)-1II-pyrazoi-4-yl]-1 -(4-nitrobenzyl)-211-tetrazoie; 5-[5-chloro-1-(3-chlorophenyi)-IH-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazoie; 5-[5-ehloro-I -(3-ehlorophenyl)-1 H-pyrazol-4-yI]-1 -(4--nitrobenzyl)-2H-tetrazole; 5-[5-chioro-1-(4-chiorophenyi)-1II-pyrazoi-4-yll-2-(4-nitrobenzyl) -211-tetrazole; 5-[5-ehloro-1 -(4-chlorophenyl)-1II-pyrazoi-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-ch!oro-1 -(2,3-diehioroplienyl)-] H-pyrazo[-4-yl]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2,3-dichlorophenyl)-1II-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-ehloro-1 -(2,4-dichlorophenyl)-1 H-pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetraz.ole; 5-[5-chloro-1 -(2,4-diehlorophenyl)-1 H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazoie; 5-[5-chloro-1 -(2,5-dichlorophenyi)-1 II-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[5-chloro-1 -(2,5-dichlorophenyl)-1H-pvrazol-4-yI]-1-(4-nitrobenzyl)-2H-tetrazble; 5-[5-chloro-1 -(2,6-dichiorophenyl)-1H-pyrazol-4-ylj-2-(4-nitrobcnzyl)-21-I-tetrazolc; 5-[5-chloro-1 -(2,6-dichiorophenyl)-1I-1-pyrazoi-4-yi]-1-(4-nitrobenzyi)-211-tetrazole; 5-[5-chloro-1 -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(3,4-dichiorophenyl)-I H-pyrazol-4-yl]-1 -(4-nitrohenzyl)-211-tetrazo[e; 5-[5-chloro-1 -(3,5-dichiorophenyl)-1II-pyrazol-4-yll-2-(4-nitrobenzy[)-211-tetrazole; 5-[5-ch]oro-1 -(3,5-dichlorophenyl)-1 T-1-pyravol-4-yl]-1 -(4-nitrohenv.yl)-2H-tetrazole; 5-11 -(2-bromophcnyl)-5-chloro-1H-pyrazol-4-yl]-2-(4-nitrobenzyi)-2H-tetrazole; 5-[1-(2-brornophenyl)-5-chioro-1 H-pyTazol-4-yIJ-1 -(4-nitrobenzy])-21-I-tetrazoie; 5-[I -(3-hrornophenyl)-5-ehloro-1H-pyrazol-4-yI]-2-(4-nitrobcnzyl) -2H-tctrazolc; 5-11 -(3-bromophenyl)-5-chloro-1TI-pyrazol-4-yl]-1 -(4-nItrobenzy)-2II-tetrazo1e; 5-fl -(4-bromophenyl)-5-chloro-I H-pyrazol-4-yI]-2-(4-nitrobenzyl)-2H-tetravole; 5-[1 -(4-bromophenyl)-5-chloro-1I-I-pyrazol-4-yl]-1 -(4-nitrobenzyi)-2H-tetrazole; 5-[5-chloro-I -(4-fluorophenyl)-1 H-pyrazol-4-yl] -2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-fluorophenyl)-] H-pyrazo1-4-y1]-1-(4-nitrobenzy)-2H-ietrazo1e; 5-[5-ehloro-1 -(2-fiuorophenyl)-11-I-pyrazol-4-yfl-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(2-fluorophenyl)-IH-pyrazol-4-ylj-1 -(4-nilrobenzyl)-2H-ietrazole; 5-[5-ehloro--(2,3-diwethylphenyl)-1 H-pyrazol-4-yl]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(2,3-dimethylphenyl)-1 II-pyrazol-4-yfl-1 -(4-nitrobenzyl)-211-tetrazole; 5-{5-chloro-1 -(2,4-dimethylphenyl)-IH-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1-(2,4-dirnethylphenyl)-l H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[5-cliloro-1 -(2.5-dimethylphenyl)-l H-pyrazo1-4-y1]-2-(4-nitrobenzy1)2H-tetrazo1e; 5-[5-ehloro-I -(2,5-dimethylphenyl)-I H-pyrazol-4-yI]-I -(4-nitrobenzyl)-21-1-tetrazole; 5-[5-chloro-1 -(2.6-dimethylphcnyl)-1Ii-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2.6-dimethylphenyl)-1I-1-pyrazol-4-yl]-1 -(4-nitrobenzyl)-21-I-tetraz&e; 5-[5-ch!oro-I -(2,4-dimethylphenyl)-I H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tctrazolc; 5-[5-chloro-1 -(3.4-dimethylphenyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2F1-tetrazole; 5-[5-chloro-1-(3,5-dimethylphenyl)-IH-pyrazol-4-ylj-2-(4-nitrobenzy]) -2H-teirazok; 5-[5-chloro-1 -(3.5-dirncthylphcnyl)-1H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-{5-chloro-1-(2-ethylphenyl)-1II-pyrazol-4-vfl-2-(4-nitrobenzyl) -21-I-tetrazole; 5-[5-chloro-1 -(2-ethylphenyl)-1 R-pyrazol-4-yl]-I -(4-nitrobenzyl)-2H-tetrazole; 5-[5-ehloro-I -(4-ethylphenyl)-1 1I-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[5-chloro-1 -(4-ethylphenyl)-1 H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1-(4-rnethoxyphenyl)-1 H-pyrazol-4-yI]-2-(4-nitrobenzyl)-21-1-tetrazole; 5-[5-ch!oro-1 -(4-methoxyphenyl)-lfI-pyrazol-4-yll-I -(4-nitrobenzyl)-2H-tetrazole; 3-[5-ehloro-1 -(2-methyiphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-Ietrazole; 5-[5-ehloro-1-(2-methylphenyl)-IH-pyrazol-4-yI]-i -(4-nitrobenzyl)-2H-tetrazolc; 5-[5-eh]oro--(4-methylphenyl)-I I-T-pyrazo!-4-yI]-2-(4-nitrobcnzyl)-211-tctrazole; 5-[5-chloro-1 -(4-methyiphenyl)-1II-pyrazol-4-yfl-1 -(4-nitrobenzyl)-2H-tetrazole; 5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-bromo-1 -methyl-I H-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-tetrazole; 5-(5-bronio-1 -elhyl-1 H-pyrazol-4-yI)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-hromo-1 -ethyl-1H-pyrazol-4-y1)-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-hromo-1-(2-rnetliylpropyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl) -2H-tetrazole; 5-L5-brorno-1-(2-methylpropyt)-1 H-pyrazol-4-yl]-I -(4-nitrohenzyl)-21-I-tetrazole; 5-(1-benzyl-5-hromo-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(1-benzyl-5-bromo-1H-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-tetrazole; 5-(5-hromo-1 -phenyli H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-te.trazole; 5-(5-bromo-1-phenyl-1II-pyrazol-4-yl)-1-(4-nitrobenzyl)-21I-letrazole; 5-[5-bromo-1-(2-ehlorophenyl)-1H-pyrazol-4-yI]-2-(4-nitrohcnzyl) -2H-tetrazolc; 5-[5-bromo-I -(2-ehlorophenyl)-1 II-pyrazol-4-yfl-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-bromo-1 -(3-elflorophenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(3-ehlorophcnyl)-1 H-pyrazol-4-yfl-1 -(4-nitrobenzy])-2T-T-tetrazole; 5-[5-brorno-1 -(4-chiorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2F1-tetrazole; 5-15 -brorno-1 -(4-chlorophenyl)-1 II-pyrazol-4-yfl -1 -(4-nitrobenzyl)-21 1-tetrazole; 5-[5-bromo-1 -(2.3-dichlorophenyl)-1 H-pyrazol-4-yfl-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,3-dichlorophenyl)-1 H-pyrazol-4-ylj-l -(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2,4-dichEorophenyl)-1 H-pyrazo-4-yi]-2-(4-nitrobcnzyl)-2H-tetrazoIe; 5-[5-brorno-1 -(2,4-dich1oropheny1)-lFI-pTazo1-4-y1]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2.5-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,5-dichlorophenyl)-1 H-pyrazo!-4-yI]-1 -(4-nitrohenzyl)-211-tctrazole; 5-[5-brorno-1-(2,6-dichlorophenyl)-IH-pyrazol-4-yl]-2-(4-nitrobenzyl) -211-tetrazole; 5-[5-broino-1 -(2,6-dich1oropbeny-H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(3,4-dichlorophcnyl)-1 I-I-pyrazol-4-yl] -2-(4-nitrobcnzyl)-2H-tctrazolc; 5-[5-bromo-1 -(3,4-dich1oropheny-1 H-pyrazol-4-vl]-1 -(4-nitrobenzy-2H-tetrazoie; 5-[5-hrorno-1 -(3,5-dichiorophenyl)-I H-pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetrazo!e; 5-[5-hromo-1 -(3,5-dichlorophenyl)-1 i1-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-bromo-1 -(2-brornophenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-J -(2-bromophenyl)-1H-pyrazol-4-ylj-1 -(-nitrohenzyI)-2H-tetrazo1e; 5-[5-hromo-1 -(3-bromophenyl)-I H-pyrazol-4-y!]-2-(4-nitrohenzy[)-21-T-tetrazole; 5-[5-bromo-1 -(3-brornophenyl)-11-I-pyrazol-4-yll-l-(4-nitrobenzyl)-2F1-tetrazole; 5-[5-bronio-1-(4-brornophenyl)-1I-{-pyrazol-4-yl]-2-(4-nitrobenzyl) -21-1-tetra.zole; 5-[5-bromo-l -(4-hromopheny!)-1 1-I-pyrazol-4-yI]-1 -(4-nitrohenzyl)-21-1-tetrazole; 5-[5-brorno-1-(4-fluorophenyl)-11I-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazole; 5-[5-hromo-I -(4-fluorophenyl)-1H-pyrazol-4-yIJ-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1-(2-fkorophenyl)-1II-pyrazol-4-yfl-2-(4-nitrobenzyl)-211-tet. razole; 5-[5-brorno-I -(2-fluorophenyl)-1 H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2,3-dirnethylphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzvl)-2H-tetrazole; 5-15-broino-1-(2,3-dimethy1pheny1)-1H-pyrazo1-4-y1]-1- (4-nitrobenzy-2M-tetrazo1e; 5-[5-brorno-I -(2,4-diniethylphenyl)-1 H-pyrazol-4-yI]-2-(-nitrohenzyI)-2H-tetrazo1e; 5-[5-hromo-1 -(2,4-dimethyiphenyl)-11 I-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-bronw-l-(2,5-dimethylphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-ietrazole; 5-[5-brorno-1-(2,5-diniethylphenyl)-1H-pyrazol-4-yfl-i-(4-nitrobenzyl) -2H-tetrazole; 5-[5-brorno-l -(2,6-dimethyiphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-letrazole; 5-[5-brorno-1 -(2.6-dirnethyiphenyl)-lH-pyrazol-4-yll-1-(4-nitrobenzyl)-2H-Letrazoie; 5-[5-bromo-1 -(3,4-dirnethylphenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-{5-bromo-1 -(3,4-dimethylpheny)-1 H-pyrazol-4-yll-I-(4-nitrobenzyl)-211-tetrazole; 5-[5-brorno-1-(3.5-dirnethylphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazole; 5-15-bromo-l-(3,5-dimethylphenyl)-1H-pyrazol-4-ylj-1-(4-nitrobenzyl) -2H-tetra2ole; 5-[5-bromo-l-(2-etliylphenyl)-1H-pyrazol-4-vl]-2-(4-nitrobenzyl) -2H-tefrazole; 5-[5-bromo-1 -(2-ethylpheny])-1H-pyrazoi-4-yl]-l-(4-nitrobcnzyl)-2H-tetrazo!e; 5-[5-bromo-1 -(4-ethylphenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1 -(4-ethylphenyl)-lH-pyrazol-4-yl]-l -(4-nitrobenzyl)-2H-telrazole; 5-[5-brorno-i -(4-methoxyphenyl)-H-pyrazol-4-yfl-2-(4-nitrobenzyl)-2H-tetrazo!e; 5-[5-brorno-1 -(4-methoxyphenyl)-1H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2-methyiphenyl)-1 H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2i-I-tetrazole; 5-[5-brorno-1 -(2-mcthylphenyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-methyiphenyl)-1H-pyrazol-4-y]j-2-(4-nitrobenzyl)-21-I-tetrazole; 5-L5-bromo-1 -(4-methylphenyl)-1 H-pyrazol-4-ylj-1 -(4-nitrobenzyl)-2H-tetrazolc; 5-(5-iodo-1 -methyl-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-iodo-1 -mcli yl-I H-pyraz&-4-yl)-I -(4-nitrobenzyl)-2H-tetrazole; 5--ethy1-5-iodo-1H-pyrazoL4-y1)-2-(4-nitrobenzyl)-2H-tetrazo1e; 5-(I -ethyl-5-iodo-I I-I-pyrazoh4-yl)-1 -(4-nitrohenzyl)-2l-1-tetrazole; 5-[5-iodo-1 -(2-methyipropyl)-1II-pyrazol-4-yll-2-(4-nitrobenzyl)-2i1-tetrazole; 5-[5-iodo-1 -(2-rnethylpropyl)-1H-pyrazol-4-yl]-1 -(4-nitrobeirzyl)-2H-tetrazole; 5-(l-henzyl-5-iodo-1 H-pyrazol-4-yI)-2-(4-riitrobenzyl)-2H-tetrazole; 5-(1-benzyl-5-iodo-1H-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-teirazole; 5-(5-iodo-1 -phenyl-l H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-iodo-1-phenyl-lII-pyrazol-4-yl)-1 -(4-nitrohcnzyl)-211-tctrazolc; 5-[1 -(2-chlorophenyl)-5-iodo-H-pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[1 -(2-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-l-(4-nitrobenzyl) -21-I-telrazole; 5-{1 -(3-chlorophenyl)-5-iodo-1II-pyrazok4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-F) -(3-chIorophenyI)-5-iodo-lH-pyrazo1-4-y1]--(4-nitrohenzyl)-2H--tetrazole; 5-[l-(4-chlorophenyl)-5-iodo-1H-pyrazol-4-yll-2-(4-nitrobenzyl) -211-tetrazole; 5-[l-(4-chlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-l-(4-nitrohenzyl)-2H-tetrazole; 5-[1-(2,3-diehlorophenyl)-5-iodo-1M-pyrazoi-4-yij-2-(4-nitrobenzyl) -2H-tetrazole; 5-[i -(2,3-dichloropheny!)-5-iodo-1 H-pyrazol-4-yIJ-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[1-(2,4-dichlorophenyl)-5-iodo-1H-pyrazoi-4-yi]-2-(4-nitrobenzyl) -2H-tetrazole; 5-[1 -(2,4-diehiorophcny!)-5-iodo-i H-pyrazo]-4-yIj-] -(4-nitrobcnzyl)-21-I-tctrazo]e; 5-[1-(2,5-dichlorophenyl)-5-iodo-1I-I-pyrazol-4-yi]-2-(4-nitrobenzyl) -211-tetrazoie; 5-[1-(2,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-(4-nlirobenzyl) -2H-tetrazole; 5-[1-(2,6-dichlorophenyl)-5-iodo-1 I-I-pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[1 -(2,6-diehlorophenyi)-5-iodu-1H-pyrazo]-4-yi]-i-(4-niirobenzyl) -2M-telrazo]e; 5-[I -(3,4-dichlorophenyl)-5-iodo-1 H-pyrazol-4-y!]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1-(3.4-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-(4-nitrobcnzyl) -2H-tctrazolc; 5-11-(3,5-dichlorophenyl)-5-iodo-1II-pyrazol-4-yii-2-(4-nitrobenzyl) -21I-tetrazole; 5-fl -(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]--(4-nitrobenzyl)-2H-tetrazo!e; 5-[1-(2-bromopheny1)-5-iodo-1H-pyrazo1-4-y1-2-(4-nitrobenzy1) -2H-tetrazoic; 5-fl -(2-brornophenyl)-5-iodo-I H-pyrazol-4-ylj-i-(4-nitrobenzyl)-2H-tetrazoie; 5-[1 -(3-brornophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazoie; 5-[1-(3-bromopheny1)-5-iodo-iII-pyrazo1-4-v1-i-(4-nitrobenzy1) -2II-tetrazo1e; 5-[1-(4-bromophenyl)-5-iodo-1H-pyrazol-4-yi]-2-(4-nitrobenzyl) -2H-tetrazole; 5-[1 -(4-bromophcnyl)-5-ioclo-1H-pyrazol-4-yl]-1 -(4-nitrobcnzyl)-2H-tetrazole; 5-[1 -(4-1]uorophenyl)-5-iodo-IH-pyrazol-4-yl]-2-(4-nitrobenzyl) -21-I-tetrazole; 5-[1 -(4-fluorophenyi)-5-iodo-1 H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[i -(2-fluoropheny!)-5-iodo-1i-I-pyrazol-4-y[]-2-(4-nitrobenzyl) -2H-tetrazole; 5-fl -(2-fluoropheny1)-5-iodo-1H-pyrazoi-4y1i-1-(4-nitrobenzyl)-2H-tetrazole; 5-fl -(2,3-dimethylphenyl)-5-iodo-1II-pyrazoi-4-yl]-2-(4-nitrobeuzyl) -2H-tetrazoie; 5-[i -(2,3-dirnethylphenyl)-5-iodo-1 H-pyrazol-4-ylj-1 -(4-nitrobenzyl)-2H-teirazole; 5-[1 -(2,4-climethylphcnyl)-5-iodo-1H-pyrazoi-4-yl]-2-(4-nitrobcnzyl) -2H-tetrazoic; 5-fl -(2,4-dimethylphenyl)-5-iodo-1H-pyrazoi-4-yli-1-(4-nitrobenzyl) -211-tetrazole; 5-[1 -(2,5-dirnethy[phenyl)-5-iodo-1 H-pyravoI-4-yl]-2-(4-nitrobenzyl)-2H-telrazole; 5-[1 -(2,S-dimethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-1 -(4-riitrohenzyl)-2H-tetrazole; 5-Li -(2,6-dimethylpheny!)-5-iodo-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2} i-tetrazole; 5-fl -(2,6-dimethylphenyl)-5-iodo-iII-pyrazol-4-yIl-1 -(4-nitrobenzyl)-211-tetrazoie; 5-[1-(3,4-dirnethylphenyl)-5-iodo-IH-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazole; 5-fl -(3,4-dirncthylphenyl)-5-iodo-I H-pyrazol-4-ylj-1 -(4-nitrobcnzyl)-2H-tetrazole; 5-11-(3,5-dimethylphenyl)-5-iodo-1II-pyrazol-4-yil-2-(4-nitrobenzyl) -211-tetrazole; 5-[1-(3,5-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-1-(4-nitrobenzyl) -2H-tetrazole; 5-[1-(2-cthylphcny-5-iodo-lH-pyrazo1-4-yfl-2-(4-nitrobenzy1)-2IT-tetraz&e; 5-[1 -(2-ethvlphenyl)-5-iodo-i H-pyraz&-4-ylj-I -(4-nitrobenzyl)-2H-tetrazolc; 5-[1 -(4-cthylphcnyl)-5-iodo-1H-pyrazol-4-yfl-2-(4-nitrobenzyl)-2H-tetrazole; 5-Il-(4-ethylphenyl)-5-iodo-IH-pyrazol-4-ylj-I -(4-nittobenzyl)-2H-tetrazolc; 5-[5-iodo-l-(4-methoxyphcnyl)-1 H-pyrazol-4-yfl-2-(4-nitrobenzyl)-211-tetrazole; 5-[5-iodo-1 -(4-methoxyphenyl)-1 H-pyrazol-4-yll-l -(4-nitrobenzyl)-2H-tetrazole; 5-[5-iodo-1-(2-methylphenyl)-l H-pyrazol-4-yI]-2-(4-nitrobenzyl)-21--T-tctrazole; 5-[5-iodo-1 -(2-methylphenyl)-l II-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[5-iodo-1-(4-rnethylphenyl)-l H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; or 5-[S4odo-l-(4-methylphenyl)-l H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole.
The present disclosure firnher provides a process for preparing a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isorners thereof of formula I, S, / NN R1
NN
wherein: R1 is selected from H, Cl, Br or I; R2 is selected fi'oin hydrogen or a straight chain or a branched C17 alkyl; wherein said alkyl is optionally substituted with a phenyl group; and the substituent when present in thc phenyl group is one or more substituent independently selected from CI, Br, F, I, NO2, CN, Ci.s alkyl, phenyl, or a C-C4 alkoxy; R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or morc substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I. C15 alkyl, phenyl, or a Ci-C4 alkoxy; said process comprising: /
N
Formula II treating a compound of formula II with a reagent and an organic solvent selected from N,N-dimethylforrnamide, N,N-dimethylaeetarnide. N-rnethyl-2-pyrrolidone, acetonitrile, acetone, diehioromethane, I,2-diehloroethane, methanol, tetrahydrofuran, toluene, xylene, henzene or water to obtain a compound of formula I with It2 as hydrogen, its derivatives, salts, stereo-isomers, or regio-isorners thereof; wherein, R is selected from H, Cl, Br or I; It3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy; and said reagent is selected from an optionally substituted sodium aiide h the presence of either an ammonium halide such as ammonium chloride, ammonium is bromide or ammonium iodide or a tri-n-hutyl tin halide such as tri-n-butyl tin chloride, tri-n-hutyl tin bromide or tri-n-butyl tin iodide; and optionafly alkylating the above compound of formula I with a dialkyl sulfate or alkyl halide such as methyl iodide or methyl bromide, in presence of a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine. pyrrolidine or N,N-dimethylaniline, to obtain a compound of formula I, its derivatives, salts, stereo-isomers, or regio-isoniers thereof, wherein R2 is selected from a straight chain or a branched C7 alkyl.
Another embodiment of the present disclosure provides a process for preparing a substituted tctrazole compounds, its derivatives, salts, stereo-isomers, or rcgio-isomers thereof of forniula I, comprising: treating a compound of formula IT with an optionally substituted sodium azidc in the presence of either an ammoniuni halide, such as ammonium chloride, ammonium bromide or ammoniurn iodide; and a polar solvent selected from N,N-dimetFyllormamide, N,N- dimethylaeetamide, N-methyl-2-pyrrolidone or water or a tri-n-butyl tin halide such as tn-n-hutyl tin chloride, tri-n-bulyl tin bromide or tri-n-butyl tin iodide in presence of a non polar solvent such as tolucnc, xylcne or benzene, to obtain a compound of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof, wherein It2 is hydrogen.
Another embodiment of the present disclosure provides a process for preparing a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof of formula!, comprising: N.M\ L/__NH2 Formula ifi treating a compound of formula ifi with sodium nitrite and cuprous halide selected from cuprous chloride, cuprous bromide -or cuprous iodide, with a mineral acid selected from hydrochloric acid, hydrobromic acid, or sulfuric acid, to obtain a compound of formula II; wherein K3 is selected from a straight or a branched chain C1..7 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a CrC4 alkoxy;-and treating the compound of formula II with a substituted sodium azide in the presence of either an ammonium halide such as ammonium chloride, ammonium bromide or ammonium iodide; and a polar solvent selected from N,N-dimethylfonnamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, or water, or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-butyl tin bromide or tri-n-butyl tin iodide in presence of a non polar solvent such as toluene, xylene or benzene, to obtain the compound of formula I, its derivatives, salts, stereo-isomers, regio-isomers thereof, wherein R2 is hydrogen.
Yet another embodiment of the present disclosure provides a process for preparing a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof of formula!, comprising: treating malononitrile with a compound of formula V in presence of acetic anhydride to obtain a compound of formula lv;
CN
Formula V, Formula W wherein R is independently selected from a straight or a branched C14 alkyl; treating the compound of formula IV with an optionally substituted N-alkyl hydrazine sulfate, or an optionally substituted N-alkyl hydrazine, or an optionally substituted N-aryl hydrazine sulfate, or an optionally substituted N-aryl hydrazine, and a base selected from an S alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrmolidine or N,N-dimcthylanilinc, in the presence of an alcohol selected from methanol, ethanol or propanol to obtain a compound of formula III, /
N NH2
Formula III wherein R3 is selected from a straight chain or a branched chain C14 alkyl or a C5 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more phenyl group; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, Cj2 ailcyl, phenyl or C1f4 alkoxy; treating the compound of fomiula Ill with sodium nitrite and cuprous halide selected from cuprous chloride, euprous bromide or euprous iodide, with a mineral acid selected from hydrochloric acid, hydrobromic acid, or sulfuric acid, to obtain a compound of formula II; treating the compound of formula Ii with sodium azide in the presence of either an ammomum halide selected from ammonium chloride, ammonium bromide or ammonium iodide; and a polar solvent selected from N,N-dirnethylformamide, N,N-di methylacetaniide, N-methyl-2-pyrrolidone, or water, or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-butyl tin bromide or trin-butyl tin iodide in presence of a non polar solvent such as toluenc, xylene or benzene, to obtain a compound of formula I. its derivatives, salts, stereo-isomers, regio-isomers thereof wherein R2 is hydrogen.
Still another embodiment of the present disclosure provides a process for preparing a compound of formula I, its derivatives, salts, stereo-isomers, regio-isomers thereof, comprising: treating a compound of formula H with an optionally substituted sodium azide in the presence of either an ammonium halide such as ammonium chloride, ammonium bromide or ammonium iodide, and a polar solvent selected from N,N-dimethylforrnamide, N,N- dimethylacetamide, N-methyl-2-pyrrolidonc, or water; or a tri-n-butyl tin halide such as tn-n-S butyl tin chloride, tni-n-butyl tin bromide or tri-n-butyl tin iodide in presence of a non polar solvent such as toluenc, xylene or benzene, to obtain a compound of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof wherein R2 is hydrogen; and alkylating the above compound of formula I with a dialkyl sulfate, or alkyl halide such as methyl iodide or methyl bromide in presence of a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-dimethylanilinc, in the presence of a polar solvent N.N-dimethylforrnamide, N,N-dimethylacetamide, N-methvlpyrrolidone.
acetonitrile. acetone, dichlorornethane, I,2-dichioroethane. methanol, tetrahydrofuran or water, to obtain a compound of formula I, its derivatives, salts, stereo-isomers, regio-ison-iers thereof wherein R2 is selected from a straight chain or a branched C17 alkyl.
Further, an embodiment of thc present disclosure provides a process preparing a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof of formula 1, comprising: treating malononitrile with a compound of formula V in presence of acetic anhydride to obtain a compound of formula IV;
ON
R4 NC'R4 Formula V. Formula IV wherein R4 is selected from a straight or a branched C14 alkyl; treating the compound of formula IV with an optionally substituted N-alkyl hydrazine sulfate, or an optionally substituted N-aryl hydrazine sulfate, and a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N.N-dimethylaniline, in the presence of an alcohol selected from methanol, ethanol or propanol to obtain a compound of formula IlL /
N
ON Formula III wherein R3 is selected from a straight chain or a branched chain C14 alkyl or a C6 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more phenyl group; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, Ci2alkyl, phenyl or C1C4 alkoxy; treating the compound of formula Ill with sodium nitrite and cuprous halide selected from cuprous chloride, cuprous bromide or cuprous iodide, with a mineral acid selected from hydrochloric acid, hydrobromic acid, or sulfuric acid, to obtain a compound of formula II; treating the compound of formula U with sodium azide in the presence of either an ammonium halide selected from ammonium chloride, ammonium bromide or ammonium iodide; and a polar solvent selected from N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, or water; or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-butyl tin bromide or tri-n-butyl tin iodide in presence of a non polar solvent such as toluene, xylene or benzene, to obtain a compound of formula I. its derivatives, salts, stereo-isomers, regio-isomers thereof wherein R2 is hydrogen; and alkylating the compound of formula I, wherein R2 is hydrogen, with a dialkyl sulfate.
or alkyl halide such as methyl iodide or methyl bromide in presence of a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an allcali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidirie or N,N-dimethylaniline, in the presence of a polar solvent N,N-dimethylformamide, N,N-dimethylacetarnide, N-methylpyrrolidone, acetonitrile, acetone, dichloromethane, 1,2-dichloroethane, methanol, tetrahydrofuran or water, to obtain a compound of formula I, its derivatives, salts, stereo-isomers, regio-isomers thereof wherein R2 is selected from a straight chain or a branched C1.
alkyl.
Another embodimeni oF the present disclosure provides a process for preparing a substitutcd tctrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof of formula I. comprising: treating 5-chloro-1 -methyl-lIJ-pyrazole-4-carbonitrile compound with sodium azide in the presence of either ammonium chloride, and N,N-dimethylformamide, or tri-n-butyl tin chloride and toluene to obtain 5-(-ehIoro-l-methyl-1H-pyrazo1-4-yl)- 21/-tetrazolc) of formula I, wherein R2 is hydrogen.
Another embodiment of the present disclosure provides a process for preparing a compound of formula I, its derivatives, sahs. stereo-isomers, or regio-isomers thereof; comprising: treating 3 -chioro-1-methyl-1H-pyrazole-4-carbonitrile compound th sodium azidc in thc prcscncc of cithcr ammonium chloride, and N,N-dimcthylformamide; or tri-n-butyl tin chloride and toluene, to obtain 5-(5-chloro-l-methyl-1H-pyrazol-4-yl)- 2H-tetrazole) of formula 1, wherein R2 is hydrogen; and mcthylating 5-(5-chloro-1 -methyl-1Ji-pyrazol-4-yl)-211-tctrazole) with dimethyl sulfate and potassium carbonate in the presence of acetone, to obtain 5-(5-chloro-i-rneihyl-lH-pyrazol-4-yl)-2-methyl-211-tetrazole of formula 1; wherein R2 is a methyl group.
[he present disclosure further provides a process preparing a substituted tetrazole compounds, its derivatives, salts, stereo-isomers, or regio-isomers thereof of formula I,
I NN R1
Formula I wherein R1 is selected from H, Cl, Br or I; R2 is selected from hydrogcn or a straight chain or a branched Cj7 alkyl; wherein said alkyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Cl, Br, F, I, NO2. CN, C15 alkyl, phenyl, or a C-C alkoxy; and R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted th one or more substituent independently selected from Cl, Br, F, I, or phcnyl; said aryl group is optionally substituted with one or more substituent independently selected flom Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy; said process comprising: reacting a compound of formula VII with an alkylating agent such as alkyl halide, or dialkyl sulfate in the presence of a base selected from alkali metal hydroxide base, such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or organic bases such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-dimethylaniline, to obtain a compound of formula VI; Formula VII Formula VI wherein: R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I. or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy; and halogenating the compound of fonnula VI with a halogenating agent selected from N-chlorosuccininiide, N-bromosuccinimide or N-iodosueeininiide in the presence of polar solvent selected from N,N-diniethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, acetonitrile, acetone, dichloromethane, 1,2-diehloroethane, methanol, tetrahydrofuran, ethyl acetate, or butyl acetate, to obtain the compound of formula I. In an aspect of the present disclosure, the compound of formula VII is prepared by a process comprising: treating a compound of formula X with phosphoryl chloride in the presence of a polar solvent selected from N,N-dimethylformamide, N.N-dimethylacetamide, N-methyl-2-pyrrolidone, acctonitrile, dichioromethane, l,2-dichlorocthane, or tetrahydrofliran. to obtain a compound of formula IX; /
ND
Formula X Forniula IX wherein: R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, T, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C1A allcyl, phenyl, or a C1-C4 alkoxy; treating the compound of formula IX with hydroxylamine hydrochloride in the presence of an alcohol selected from methanol, ethanol or propanol, to obtain a compound of formula Vlfl; and /
N N
U
Formula VIII treating the compound of formula VIII with sodium azide in the presence of ammonium chloride and a polar solvent selected from N.N-dimcthylforn-iamide, N,N-di methylacetamide, N-methyl-2-pyrrolidone,tetrahydrofuran or watcr, to obtain thc compound of formula VII.
In another aspect of the present disclosure, the compound of formula VII is prepared by a process comprising: treating a compound of Formula X with iodine and a strong oxidizing agent such as hydrogen peroxide in aqueous medium to obtain a compound of formula XII; /
N N \ / I')
NN
U
Formula X Formula XII wherein: R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I. or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, Ci5 alkyl, phenyl, or a Ci-C4 alkoxy; treating the compound of formula XII with either potassium ferrocyanide and palladium (11) acetate in the presence of a base selected from alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base selected from sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; and a polar solvent selected from N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, acetonitrile, acetone, dichloromethane, 1,2-dichloroethane. methanol. tetrahydrofuran or water; or sodium cyanide or copper cyanide in the presence of cuprous halides such as cuprous iodide and N,N-dimcthyl ethylene dianiine with a non polar solvent such toluene, xylene, or henzene, to obtain a compound of formula XI; and /
N
Formula XI treating the compound of formula XI with sodium azide and either tri-n-butyl tin chloride in the presenec of a non polar solvent selected from toluene, xylene or henzene; or ammonium chloride and N,N-dimethylfonnaniide, to obtain the compound of formula VII.
An embodiment of the present disclosure provides a process for preparing a compound of formula 1. its derivatives, salts, stereo-isomers, or regio-isomers thereot comprising: reacting 5-(1-methyl-1H-pyrazol-4-y-2H-tetrazole with methyl iodide and dimethyl sulphate, th the presence of potassium hydroxide and potassium carbonate to obtain 2-niethyl-5-( I -methyl-I fJ-pyrazol-4-yl)-2H-tetrazole; and chlorinating 2-rnethyl-5 -(1 -methyl-1H-pyrazoi-4-yi)-2J-T-tetrazole th N- ehlorosuccinimide, in the presence acetonitrile, to obtain 5-(5-chloro-l-rnethyl-IIJ-pyrazol-4-yl)-2-methyl-2H-tetrazole of formula I. Yet another embodiment of the present disclosure provides a process for preparing 5- (5-ehioro-1 -rnethyl-1H-pyrazole-4-yl)-2-metliyl-2H-tetrazole of formula I by a process comprising: treating l-mcthyl-IH-pyrazole with phosphoryl chloride in the presence of N,N-dimethylformamide, to obtain 1-methyl-1 H-pyTazol e-4-carhaldehyde; treating the 1-methyl-i H-pyrazole-4-carhaldebydc with hydroxylamine hydrochloride in the presence of ethanol, to obtain 1-methyl -1H-pyrazole-4-carbaldehyde oxime; treating the 1-methyl-1H-pyrazole-4-carbaldehyde oxime with sodium azide in the presence of amrnonium ehluridc and N,N-cliinethylformamide, to form the 5-(1-rnethyl-1H-pyrazol e-4-yl)-2JJ-tetrazole; reacting 5-(1-methyl-1H-pyrazol-4-yl)-211-tetrazole with methyl iodide and dimethyl sulphate, in the presence of potassium hydroxide and potassium carbonate to obtain 2-methyl-5-( 1-methyl-I I!-pyrazol-4-yI)-2H-tetrazole; and chlorinating 2-methyl-5-(1-methyl-lH-pyrazol-4-yl)-2H-tetrazolc with N- chlorosuccinimide, in the presence acctonitrile, to obtain 5-(5-chloro-1 -methyl-1H-pyrazol-4-yl)-2-mcthyi-2/J-tetrazole of formula I, Another embodiment of the present disclosure provides a process for preparing 5-(5-ch1oro-l-methyl-l1-I-pyrazole-4-y-2-methyl-2H-tctrazole of formula I by a process comprising: treating 1-methyl-1H-pyrazole with iodine and hydrogen peroxide in aqueous medium to obtain 4-iodo-1-methyl-i II-pyrazole; treating the 4-iodo-1-methyl-1H-pyrazole with potassium ferrocyanidc and palladium (II) acetate in the presence of sodium carbonate, and N,N-dimethylacetamide, to obtain I-methyl-1H-pyrazole-4-earbonitrile; treating the 1-rnethyl-IH-pyrazole-4-carbonitrile with sodium azide and either with tri-n-hutyl tin chloride in the presence of toluene. or ammoniurn chloride in the presence of N,N-dirnethylformamide to obtain the -0 -mcthyl-1H-pyrazol-4-yl)-2H-tetrazole; reacting 5-0 -methyl-IH-pvrazole-4-yl)-2H-tetrazole with methyl iodide and dimethyl sulphate, in the presence of potassium hydroxide and potassium carbonate to obtain 2-methyl-5-(1 -methyl-1H-pyrazol-4-yl)-2H-tetrazole; and chlorinating 2-methyl -5-( 1-methyl-1H-pyrazol-4-yl)-2H-tetrazole with N- eblorosuccinimide, in the presence aeetonitrile, to obtain 5-(5-ehloro-1 -methyl-1H-pyrazol-4-yl)-2-methyl-2H-tetrazole of formula 1.
The substituted tetrazole compounds of formula I, its derivatives, salts, stereo-isomers, or regio-isomers thereof may be prepared following independent general synthetic routes as outlined in the Schemes 1-5, Scheme 1: General route for the synthesis of compounds of formula (I) its derivatives, salts, stereo-i somers, regio-isomers thereof,
I 0)
The compound of I as above is prepared either from reaction of the compound of formula II with an optionally substituted sodium azide in the presence of an ammoniurn halide selected from ammonium chloride, ammonium bromide or ammonium iodide and a polar solvent selected from N,N-dimethylformamide, N,N-dimethylacetarnide, N-methyl-2-pyrrolidone, or water; or by reaction of the compound of formula H with an optionally substituted sodium azide in the presence of a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-butyl tin bromide or tri-n-hutyl tin iodide in the presence of a non-polar solvent such as toluene, xylene or benzenc. The reaction temperature range from 110°C to 120°C.
In the compound of Formula I above, R1 is selected from H, Cl, Br or I; R2 is hydrogen; and R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, 1, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy.
Scheme 2: General route for the synthesis of compounds of formula (I) its derivatives, salts, stereo-isomers, or regio-isomers thereof. R2
([1) NH (1) U) (J)L wherein (J) wherein R2 is R2 H selected from a straight chain or branched]7 alkyl The compound of formula I, wherein R2 is hydrogen, as above is prepared from reaction of the compound of formula II by a process as described in Scheme 1.
Compound of formula F thus obtained is alkylated with a dialkyl sulfate or alkyl halide such as methyl iodide or methyl bromide and a base selected from alkali metal hydroxide base, such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N.N-dimethylaniline, in the presence of a polar solvent selected from N,N-dirnethylformarnide, N,N-dimethylacetamide, N-methylpyrrolidone, acetonitrile, acetone, dichloromethanc, 1,2-di chioroethanc, methanol, tetrahydrofuran or water, to yield a compound of formula I; wherein R2 is selected from a straight chain or a branched C17 alkyl.
Scheme 3: General route for the synthesis of compounds of formula (I) its derivatives, salts, stereo-isomers, regio-isomers thereof N, NO + N4 NO N4 (Iv) ON (V) (III) N3 Ni N -NR, N, (II) \N_NH (I) (I) Malononitrile is reacted sith a compound of formula \T, wherein all symbols are as defined below, to yield a compound of formula IV. The reaction is carried out using acetic anhydride at a temperature in the range of 105-110°C for 2 to 3 hours to provide a compound of formula IV.
The compound of formula JV is cyclized to obtain a compound of formula 111 by a cyclization reaction. The reaction is carried out with a suitable hydrazinc such as N-alkyl hydrazine sulfate, N-allcyl hydrazine, N-aryl hydrazine sulfate, or N-aryl hydrazine, in the presence of a base selected from alkali metal hydroxide base selected from sodium hydroxide, potassium hydroxidc or lithium hydroxide; alkali metal carbonate base selected from sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base selected from triethyl amine, di-isopropyl aminc, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-dimethylaniline and an alcohol selected from methanol, ethanol or propanol for about 1-2 hours at reflux temperature.
The compound of fomrnla III is converted to a compound of formula II by treaUnent with a halogenating agent such as cuprous halide selected from cuprous chloride, cuprous bromide or cuprous iodide, and sodium nitrite in the presence of a mineral acid selected from hydrochloric acid, hydrobromic acid, or sulfuric acid at room temperature.
The compound of I, wherein R2 is hydrogen; is either prepared from reaction of the compound of formula II with an optionally substituted sodium azide in the presence of an animonium halide selected from ammonium chloride, ammonium bromide or ammonium iodide and a polar solvent selected from N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, or water; or from reaction of the compound of formula II with an optionally substituted sodium azide in the presence of a tri-n-butyl tin halide such as fri-n- butyl tin chloride, tri-n-bulyl tin bromide or tri-n-butyl tin iodide in the presence of a non-polar solvent such as toluene, xylene or henzene. I'he reaction temperature range from 110°C to 120°C.
The compound of formula I thus obtained is ailcylated with a dialkyl sul late or aikyl halide such as methyl iodide or methyl bromide and a basc selected from alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-dimethylaniline in the presence of a polar solvent selected from N,N-dimethylformami dc, N,N-dimethylacetamide, N-mcthylpyrrol idone, acetonitrile, acetone, dichloromethane, 1,2-dichloroethane, methanol, tetrahydrofuran or water to yield a compound of formula I; wherein R2 is selected from a straight chain or a branched C17 alkyl; R1 is selected from H, CI, Br or I; R2 is selected from hydrogen or a straight chain or a branched C17 alkyl; wherein said alkyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Cl, Br, F, 1, NO2, CN, C15 alkyl, phenyl, or a C1-C4 alkoxy; and R2 is selected from a straight or a branched chain Ci7alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C5 alkyl, phenyl, or a C1-C4 alkoxy; R4 is independently selected from a straight or a branched C14 ailcyl.
Scheme 4: General route for the synthesis of compounds of formula (I) its derivatives, salts.
stereo-isomers, or regio-i somers thereof.
5, / / / N-N N-N X Ct-iO NOH Ix VIII 5, 5, / / /
NAN N N
\\ / \\ / \\ /
N-NH N-N N-N 5, 2 is vn
A compound of formula X is reacted with phosphoryl chloride in the presence of a poiar solvent selected from N,N-dimethylformamide, N.N-dimethylacetamide, N-methyl-2-pyrrohdone, acetonitrile, dichloromethane, 1,2-dichloroethane, or teirahydrofuran, wherein all symbols are defined above, to yield a compound of formula IX.
The compound of formula IX is converted to a compound of formula VIII by treatment with hydroxylamine hydrochloride in the presence of an alcohol selected from methanol, ethanol or propanol at refiux temperature.
the compound of VII is prepared from reaction of the compound of formula VIII with an ammonium halide selected from ammonium chloride, ammonium bromide or ammonium iodide, and an optionally substituted sodium azide. The reaction is canied out in a polar solvent selected from N,N-dimethylformamide, N,N-dirnethylacetamide, N-rnethyl-2-pyrrolidone, tetrahydrofuran or water. ftc reaction temperature range from 110°C to 120 °C.
The compound of formula VII is further reacted wi Lb an a&ylating agent such as alkyl halide, or dialkyl sulfate and in the presence of a base selected from alkali metal hydroxide s base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-dimcthylaniline, to obtain a compound of formula \T1 Ilalogenating the compound of fonnua VI with a halogenating agent selected from N-chlorosuccinimide. N-bromosuccinimide or N-iodosuccinimide in the presence of a polar solvent selected from N.N-dimethylformamidc, N,N-dirnethyacetamidc, N-methy-2-pyrrolidone, acetonitrile, acetone, dich I oromethane, 1,2-dichloroethane. methanol, tetrahydrofuran, ethyl acetate, or butyl acetate, yields the compound of formula I. wherein: R1 is selected from II, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C17 ailcyl; wherein said alkyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substitueni independently selected from Cl, Br, F, I, NO2, CN, Cl_s alkyl, phenyl, or a C1-C4 alkoxy; and R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substitnent independently selected from Cl, Kr, F, I, pheny; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy.
Scheme 5: General route for the synthesis of compounds of formula (I) its derivatives, salts, stereo-isomers, or regio-i somers thereof, N6 NC xri xi / / /
NAN NAN N
\\ / \\ I \\ / N-NH N-N\ VII N, N,
VI I
A compound of formula X is reacted with iodine and a strong oxidizing agent such as hydrogen peroxide in aqueous medium to obtain a compound of formula XII; wherein all symbols are dcfincd above.
S The compound of formula XII is treated with either potassium ferrocyanide and palladium (II) acetate in the presence of a base selected from alkali metal hydroxides such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonates such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; and a polar solvent selected from N,N-dimelhylforrnarnide, N,N-dimethylacetamide, n-methyl-2-pyrrolidone, aeetonitrile, acetone, dichloromethane, 1,2-dichloroethane. methanol, tetrahydrofuran or waler; or the compound of formula XII is treated with sodium cyanide or copper cyanide in the presence of cuprous halides such as cuprous iodide and N,N-dimethyl ethylene diarnine in the presence of a non polar solvent such toluene, xylene, or benzene to obtain a compound of formula XI.
The compound of formula XI is converted to a compound of formula VII by treatment with sodium azide and with either tri-n-butyl tin chloride in the presence of a non polar solvent selected from toluene, xylene or benzenc; or by treatment with sodium azide with ammoniuni chloride and N,N-dirnethylformamide, to obtain the compound of formula VII.
The compound of formula VII is reacted with an alkylating agent such as alkyl halide, or dia]kyl sulfate and in the presence of a base selected from alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N.N-dimethylaniline, to obtain a compound of formula VI.
Ilalogenating the compound of formula VI with a halogenating agent selected from N-chlorosuccinimide, N-bromosuccinimide or N-iodosuccinimide in the presence of a polar solvent selected from N,N-dimcthylformamidc, N,N-dimcthylacctamidc, N-methyl-2-pyrrolidone, acetonitrile, acetone, dichloromethane, 1.2-dichloroethane, methanol, tctrahydrofuran, ethyl acetate, or butyl acetate, yields the compound of formula i.
Abbreviations The following abbreviations are employed in the examples and elsewhere herein: DMF: N.N-dimethylformamide, DCE: Dichioroethane, TIIF: Tctrahydrofuran.
A1C13: Aluminium Chloride, AIBr3 Aluminium Bromide, All3: Aluminium Iodide, 11202: Ilydrogen peroxide, Ac20: Acetic aithydride, 0CM: Dichloromethane, IICI: Ilydrochioric acid, Dl water: Dc-ionized water.
DM water: Demineralized water, M/C: Moisture content, MR: Molar ratio, T: Times, MR Melting point, UP: Boiling point, w/w: weight/weight
Examples
The disclosure will now be illustrated with working examples, which is intended to illustrate the working of disclosure and not intended to take restrictively to imply any
limitations on the scope olthe present disclosure.
All stereo-isomers or regio-isomers of the compounds of the instant disclosure are contemplated, either in admixture or in pure or substantially pure fonm Example 1: 5-(5-ehloro-1-methyl-1H-pyrazol-4-yI)-2H-tetrazole (Compound 1): The above product. 5-ehloro-l-methyl-IH-pyrazole-4-carhonitrilc (13.0 grn, 0.092 moles), was dissolved in DMF (40 ml), followed by addition of ammonium chloride (9.9 gin, 0.184 moles) and sodium azide (12.0 gm, 0.184 moles) and stirred at 100-140°C for 10-16 hours. The progress of the reaction was monitored by HPLC, The reaction mixture was cooled at 0-5°C and quenched with aqueous 1-ICI (78.0 nil) and stirred for 30-60 mm at 0-5°C.
The solid material obtained was filtered, washed with cold DM water (40 ml) and dried at 60- 65°C to yield the product. 5-(5-chloro-1-methyl-l J/-pyrazoleA-yl)-2H-tetrazole.
Dry wt: 16.2gm Yield 1.25 w1w (96%) I-IPLC purity 99.26% MP:215-219°C Example 2: Compound 1, 5-(5-chloro-!-methyl-1H-pyrazol-4-yl)-211-tetrazole: Step 1; 2-(ethoxyinethylene)malononi irile A mixture of ti'iethyl orthoformate (67.3 gm, 0.454 moles) and malononitrile (20.0 gm, 0.302 moles) in acetic anhydride (77.2 gm, 0.75 moles) was refiuxed for 4-5 hours at 110-140°C. The reaction was monitored by UC. Reaction mixture was cooled to room temperature. Concentrated the reaction mixture at 70°C at reduced pressure to yield crude solid product, 2-(ethoxymethylene)malononitrile. The crude product was further purified either by vacuum distillation to yield pure product, 2-(ethoxymethylene)malononitrile.
Drywt: 36.0gm Yield: 1.80 w/w (98%) HPLC purity: 99% MP: 65-67 °C Step 2: 5-amino-i-methyl-I H-pyrazo Ie-4-carbonitrile A solution of 2-(ethoxyrncthylene)malononitrile (20.0 gm, 0,163 moles) in methanol (80.0 ml) was slowly added to a mixture of N-methyl hydrazine sulfate (23.5 gm, 0.163 moles), triethyl amine (33.0 gm, 0.326 moles) and methanol (30.0 gm). The reaction mixture was refluxed for 1-2 hour. The progress of the reaction was monitored by HPLC. Excess methanol was distilled out at reduced pressure. To the above residue distilled water (40.0 nil) was added and the reaction mass was cooled to 0-15°C. 15% (w/v) aqueous sodium hydroxide solution (18.0 ml) was added to the above reaction mixture and the reaction mixture thereto was stirred for 30-45 mm at 0-5°C, filtered, washed with cold water (400 ml) and air dried to yield 5-amino-l -methyl-I iJ-pyrazole-4-carbonitrile at 50-75°C.
Drywt: 15.4gm Yield 0.77 w/w (77%) IIPLC purity: 98.67% MP:216-221°C Step 3: 5-chioro-1 -methyl-1H-pyrazole-4-carbonitrile A mixture of 5-amino-l-mcthyl-1H-pvrazole-4-carbonitrile (12.1 gm, 0.099 moles), hydrochloric acid (72.6 ml, strength: 35-37%) in DM water (60.0 ml) was stirred at room temperature. Reaction mixture was cooled to 0 to 5°C and sodium nitrite solution (by dissolving sodium nitrite (8.2 gm, 0.119 moles) in Dl water (240 nil)) was slowly added. The reaction mixture was stirred for 1-1.5 hours at 0 to 5°C. Urea solution [prepared by dissolving urea (1.2 grn) in DI water (6.0 ml)] is added slowly to the reaction mixture. Solid cuprous chloride (12.8 gni, 0.129 moles) was added to the above reaction mixture, stirred the reaction mixture for 3-4 hours at 0 to 5°C. Then the reaction temperature was raised to room temperature and stirred for 12-18 hours. Progress of the reaction was monitored by HPLC. to the above reaction mixture was added Dl water (120 ml) and 25% (w/v) aqueous sodium hydroxide solution (80.0 nil) to adjust the p11 to 3-3.5. 1,2-diehloroethane was poured to the reaction mixture and stirred for 10-15 mm at 45-50°C. The inorganic salt was filtered off through hyflo bed. The organic layer was separated and aqueous layer was extracted with I,2-dichlorocthane. The entire organic layer was transferred to the reaction vessel and washed with 10% brine solution (50.0 ml), The organic layer was evaporated to obtain the 5-chloro- 1 -methyl-I H-pyrazole-4-carbonitrile.
Drywt: 11.8gm Yield: 0.97 w!w (84 %) HPLC purity: 93.34% MP: 55-60°C Step 4: 5-(5-chloro-1-methyl-lII-pyrazol-4-yl)-211-tetrazole of formula I. 5-(5-chl oro-1-methyl-I H-pyrazol-4-yl)-2Jf-tetrazole of formula 1 is prepared from the above product 5-ehloro-l -methyl-1H-pyrazole-4-carhonitrile by the process as in example I. Compounds 2-30 were prepared by following the experimental procedure of Example I and! or 2 using appropria.te intermediates.
Compound R R2 -LUPAC Name No. ___ ___ _____ _____________ _____________ 2 Cl H CII2CI 13 5-(5 -ehloro-1-ethyl-i H-pyrazol-4-yl)-211- _______ _____ _____ ____________ tetrazole ___________________________ 3 Cl H (CH3)2CHC 5-[5-ehloro-1-(2-methylpropyl)-1II-pyrazol-4- ______________ ______ _____ "2 yl]-2H-tetraole 4 Cl H CH2Ph 5-(l-benzyl-5-ehloro-1H-pyrazol-4-yl)-2H-tetrazole Cl II CH5 5-(5-chloro-1-phenyl-lJf-pyrazol-4-yl)-2J1-tetrazole 6 Cl H 2 CIC6H4 5-[5-ehloro-1-(2-c.hlorophenyl)-1H-pyrazol-4- _______________ ______ ______ ______________ yl]-2H-tetrazole 7 Cl I-I 3 C1C4T1 5-[5-chloro-1-(3-ehlorophenyl)-IH-pyrazol-4- _____________ _____________ ylj-2H-tetrazole 8 Cl II 4 C1C6I-14 5-[5-chloro--(4-eblorophenyl)-iI[-pyrazol-4- _______________ _______________ yl]-2H-tetrazole 9 Cl II 2,3 Cl2 C51-13 5-[5-cbloro-I -(2,3-clichlorophenyl)-1H-pyrazol- ______________ ____________ ______ 4-yl] -2H-tetrazole Cl H 2,4 Cl2 C6113 5-[5-eh!oro-I -(2,4-diehlorophenyl)-I I I-pyrazol- ______________ ____________ ________ 4-yl] -2H-tetrazole 11 Cl II 2,5 Cl2 C61-13 5-[5-ehloro-I -(2,5-dichlorophenyl)-1 1J-pyrazol- _____________ ___________ _____________ 4-yl]-2H-tctrazole 12 Cl H 2,6 Cl2 C6H3 5-[5-chloro-1-(2,6-diehlorophenyl)-1H-pyrazol- _____________ _____ _____ _____________ 4-yl]-2f1-tetrazole 13 Cl El 3,4 Cl2 C6113 5-[5-ehloro-1-(3,4-diehlorophcnyl)-1II-pyrazol- ___________ _____ _____ _____________ 4-yl] -2 H-I etrazole 14 Cl H 3,5 Cl2 C6H3 S-[5-chloro-1 -@ ,5-diehlorophenyl)-1H-pyrazol- _____________ _____ _____ _____________ 4-y!]-21-I-tetrazole CI H 2 BrC6H4 5-[1-(2-brornophenyl)-5-chloro-1H-pyrazol-4- _____________ _____ _____ _____________ vl]-2H-tetrazole 16 Cl H 3 Br C6H4 5-[1-(3-bromophenyl)-5-ehloro-I I-J-pyrazo!-4- ______________ _____ _____ ______________ yl]-2H-tetrazole 17 Cl H 4 BrC6H4 5-[1-(4-brornophenyl)-5-chloro-1H-pyrazol-4- ____________ _____ _____________ yl]-2H-tetrazole 18 Cl I-I 4 F C6H4 5-[5-chloro-1-(4-fluorophenyl)-IH-pyrazol-4- ____ _____ _____ _____________ yl]-2H-tetrazole 19 Cl H 2 F C5H4 5-[5-ch!oro-1-(2-Iluorophenyl)-IH-pyrazol-4- _____________ _____ _____ _____________ yl] -211-tctrazolc Cl H 2,3 5-[5-ehloro-1 -(2,3-dimethvlphenyl)-1H-pyrazol- ______________ _____ _____ (CT-13)2C6H3 4--yl] -2H-tetrazole 21 Cl H 2,4 5-15-chloro-1.-(2,4-dimethvIpheny-1 11-p yrazol- ______________ (CH3)2C6H3 4-yl]-2H-tetrazole 22 Cl Ii 2,5 5-[5-chloro-I -(2,5-dimethylphenyl)-1H-pyrazol- (CI 13)2C61 13 4-yl] -2ff-tetrazole 23 Cl H 2,6 5-[5-chloro-1-(2,6-dimethylphenyl)-IH-pvrazol- (CH3)2C6H3 4-yl] -2H-tetrazole 24 Cl H 3,4 5-[5-chloro-1-(3,4-dirncthylphenyl)-1H-pvrazol- _____________ (C113)2C6113 4-yI]-211-tetrazole Cl H 3,5 5-[5-chloro-1-(3,5-dimethylphenyl)-1H-pvrazol- ________________ ______ ______ (CI 13)2C6113 4-yl]-2ff-tetrazole 26 Cl H 2CH2CH3C6 5-i5-chloro-1 -(2-ethylphenyl)-1H-pvrazol-4-yI]-H4 2H-tetrazole 27 Cl H 4CH2CH3C6 5-[5-chloro-1-(4-ethylphcnyl)-1H-pyrazol-4-yl]-H4 21/-tetrazole 28 Cl Ii 4OCHC6H4 5-[5-chloro-1-(4-rnethoxyphenyl)-IH-pyrazol-4-yll-2H-tetrazole 29 Cl Fl 2 CT-13C6H4 5-[5-chloro-1-(2-methylphenyl)-1H-pyrazol-4-yl]-2JJ-tetrazole Cl I-I 4 C113C6114 5-[5-chloro-I-(4-methylphenyl)-l1-J-pyTazol-4- __________ ______ _____ _____________ yl]-2H-tetrazole Example 3: 5-(5-bromo-1-methyl-IH-pyrazol-4-yl)-2H-tctrazole (Compound 31) 5-bronio-l -niethyl-lH-pyrazole-4-earbonitrile, (14.85 gm, 0.0798 moles), was dissolved in toluene (148 ml), and tri-n-butyl tin chloride (64.83 gm, 0.199 moles) and sodium azide (1293 gm, 0.199 moles) was added to ii. The reaction mixture was stirred at 100-115°C for 7-8 hours. The progress of the reaction was monitored by HPLC. The reaction mixture was cooled at 10-lSoC and 10% ethanolic HC1 solution (100 ml) was added and stirred for 1-1.5 hours at 10-1 5°C. The inorganic salt was filtered off, washed with ethanol (30 ml). Mother liquor and washings are collected and excess Loluene and ethanol was recovered at 50-55°C under reduced pressure. Poured di-isopropyl ether (100 ml) to the above residue and stirred the resulting solid for 1-2 hours at 20-25°C. The solid product was filtered, washed with di-isopropyl ether (30 ml) and air dried to yield the product, 5-(5- bromo-1-methyl-IH-pyrazol-4-yl)-21/-tetrazole at 60-65°C. The melting point of the 5-(5-bromo-1-methyl-i JJ-pyrazol-4-yl)-2J-T-tetrazole is 215-218°C.
Drywt 16gm Yield: 1.07 w/w (87%) HPLC purity 99.72% MP 203-207°C Example 4: 5-(5-bromo-I -methyl-1II-pyrazol-4-yl)-2H-tetrazole: Step 1: 2-(cthoxymcthylenc)rnalononitrile The preparation 2-(ethoxymethylene)malononitrile was carried out in a manner similar to that described in Step I olExample 2.
Step 2: 5-amino-I-methyl-1 ff-pyrazole-4-carhonitril e The 5-amino-i-methyl-IH-pyrazole-4-carbonifrile was synthesized according to the above method described in Step 2 of Example 2.
Step 3: 5-bromo-1-methyl-I J-/-pyrazole-4-carbonitrile A mixture of 5-arnino-1-methyl-lH-pyrazole-4-carbonitrile (20 gm, 1.63 moles) obtained from Step 2, hydrobromic acid (280 ml, strength: 48%) in DM water (605 nil) was stirred at room at 0 to 5°C and sodium nitrite solution (by dissolving sodium nitrite (16.94 grn, 0.245 moles) in Dl water (242 ml)) was slowly added. Solid cuprous bromide (37.22 gm, 0,260 moles) was added to the above reaction mixture, stirred the reaction mixture for 3-4 hours at 0 to 5°C. Then the reaction temperature was raised to room temperature and shred for 13-18 hour. To the above reaction mixture cold Di water (1000 ml) was added at 0-5°C and stirred the resulting suspension for 1-2 hours. Progress of the reaction was monitored by IIPLC. The solid product was filtered, washed with cold Di water (200 ml) and dried at 60- 65°C the product, 5-bromo-1 -methyl-I H-pyrazole-4-carbonitrile was obtained.
Drywt 21.2gm Yield 1.06 w/w (69%) HPLC purity 99.58% MP 90-93°C Step 4: 5-(5-bromo-1-methyl-1H-pyrazol-4-yl)-211-tetrazole (Compound 31) 5-(5-bromo-l-methyl-1H-pyrazol-4-yl)-2H-tctrazole was obtained from 5-bromo-1 -methyl-1H-pyrazole-4-carbonitrile, obtained in step 3 by the process as in example 3.
Compounds 32-60 were prepared by following the experimental procedure of Example 3 and/or 4 using appropriate intermediates.
Compound R1 R2 143 ITJPAC Name No. ____ ____ ____ __________________________ 32 Br II C112C113 5-(5-hromo-1 -ethyl-I H-pyrazol-4-yl)-211-tetrazole 33 Br H (CH3)2CFICII2 5-[5 -bronio-1 -(2-methylpropyl)-1 H-pyrazol- ______________ _______ ______ _______________ 4-yl]-2H-tetrazole 34 Br H CH2Ph 5-(l-henzyI-5-hromo-lH-pyrazo!-4-y-2H-tetrazole Br H C6H5 5-(5-bromo-1 -phenyl-l H-pyrazol-4-yl)-2H-tetrazolc 36 Br H 2 C1C6H4 5-[5-bromo-l-(2-chlorophenyl)-1H-pyrazol- _____________ ______ ______ __________ 4-yl] -2H-tetrazole _________________ 37 Br II 3 Cl C6114 5-[5-bromo-l-(3-chlorophenyl)-lII-pyrazol- ____________ _____ _____ ______________ 4-yl]-2H-tetrazole 38 Br 1-1 4 Cl C6H4 5-[5-brorno-l-(4-chlorophenyl)-1H-pyrazol- ____ _____ _____ ____ 4-y!]-2H-tetrazole 39 Br II 2,3 Cl2 C6H3 5-{5-bromo-l-(2,3-dichlorophenyl)-1H- ______________ ______ ______ _______________ pyrazol-4-yl]-2H-telrazole _______ Br H 2,4 Cl2 C6H3 5-[5-brorno-l-(2.4-dichlorophenyl)-1H- __________ __________ pyrazol-4-ylj -2H-tetrazole 41 Br II 2,5 Cl2 C6113 5-[5-hromo-l-(2,5-dichlorophenyl)-IH-pyrazol-4-yl] -2H-tetrazole 42 Br II 2,6 02 C6H3 5-[5-bromo-l-(2.6-dichlorophcnyl)-1IJ-pyrazol-4-yl]-2H-tetrazole 43 Br H 3,4 Cl2 C5H3 5-[5-hromo-l-(34-dichlorophenyl)-I[I- ______________ ______ ______ _______________ pyrazol -4-yfl -2J1-tctrazole 44 Br H 3,5 Cl2 C6H3 5-[5-brorno-l-(,5-dichiorophenyl)-l/I- ______________ ______ ______ _______________ pyrazol -4-yl] -2ff-tetrazole Br H 2 Br C6H4 5-[5-brorno-l-(2-bromophenyl)-lH-pyrazol- 4-yl]-2H-tetrazo] e 46 Br I-I 3 Br C6H4 5-[5-brorno-l-(3-brornophenyl)-l [-pyrazol- 4-yI]-2H-tetrazole 47 Br H 4 Br C61-14 5-[5-bromo-l-(4-hromopheny!)-1H-pyrazol- 4-yl]-2H-tetrazole 48 Br II 4 F C6114 5-[5-brorno-l-(4-lluorophenyl)-1H-pyrazol- ______________ ______ ______ _______________ 4-yl] -211-tctrazole 49 Br H 2 F C5H4 5-[5-hromo-1-(-fluorophcnyl)-1/I-pyrazo1- _____________ ______ ______ ______________ 4-yl]-2H-tetrazole Br H 2,3 5-[5-brorno-I -(2,3-dimethyiplienyl)-H- (CH3)2C6113 pyrazo!-4-y!] -2H-tetrazolc 51 13r 1-1 2,4 5-[5-brorno-I -(2,4-dimethyiphenyl)-I H- (Cl 13)2C61 13 pyrazol-4-yl]-2H-tetrazole 52 Br H 2,5 5-[5-bromo-1 -(2,5-dirnethyiphenyl)-1H- (Cl13)2C61 13 pyrazol-4-yfl -2H-tetrazole 53 Br H 2,6 5-[5-bromo-1 -(2.6-dimethylphenyl)-I H- ______________ _______ ______ (CH3)2C6H3 pyrazol-4-yl] -2H-tetrazole 54 Br H 3.4 5-[5-bromo-1-(3,4-dirnethylphenyl)-1H- (CH3)2C61-T3 pyrazol-4-yl] -2H-tetrazole Br H 3,5 -5-[5-bromo-1-(3,5-dimethylphenyl)-1H- (CH3)2C6H3 pyrazol-4-ylj -2H-tetrazole 56 Br H 2 5-[5--bronio-1 -(2-ethylphenyl)-I fJ-pyrazol-4-CH2CH3CI-14 l] -2H-tetrazole 57 Br H 4 5-[5-bromo-l-(4-ethylphenyl)-1H-pyrazol-4-CI I2CfI3C6I 14 yl] -2H-t.etrazole 58 Br H 4 OCH3C6H4 5-[5-bromo-I-(4-niethoxyphenyl)-l[J-pyrazol-4-yI] -2ff-tetrazole 59 Br H 2 CH3C6I-14 5-[5-bromo-1-(2-methylphenyl)-1H-pyrazol- 4-yl] -2H-tetrazole Br H 4 CH3C6H4 5-{5-bromo-1 -(4-methyiphenyl)-1 H-pyrazol- 4-yl] -2H-tetrazol e Example 5: 5-(5-ehloro-1-methyl-IH-pvrazol-4-yl)-2-methyl-2H-tetrazok (Compound 61): 5-(5-ehloro-1-methyl-I JJ-pyrazolc-4-yl)-2Jf-tetrazole (10,0 gm, 0.0541 moles) obtained in Example 1, or 2, was dissolved in acetone (50.0 ml). Potassium carbonate (6.0 gm, (3.0433 moles) was added and stirred for about 1 hour at 20-30°C. To this mixture, slowly added a solution of DMS (9.5 gm, 0.0757 moles) in acetone (10.0 ml) maintaining the temperature below 30°C. l'he reaction mixture was stirred at room temperature for about I hour and monitored the progress of the reaction by HPLC. The inorganic solids were filtered off Acetone was distilled off from the filtrate to obtain the crude product containing 5-(5- ehloro-l -methyl-1II-pyrazole-4-yl)-2-methyl-2H-tetrazole). its regio-isomer, 5-(5-chloro-I - methyl-1H-pyrazole-4-yl)-1 -methyl-2H-tetrazole), or mixture thereof The desired regio-isomer, 5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2-melhyl-2H-ietrazole), was isolated by column chromatography.
Drywt: 7.81gm Yield 0.78 w/w (73%) HPLC purity 99.12% MP 125-127°C Compounds 62-330 were prepared by following the experimental procedure of Example 5 using appropriate intermediates.
COmpO-R1 IUPAC Name uS No. ____ _________ __________ _____________________________________ 62 Cl CM3 CH2CH3 5-(5-chloro-I -ethyl-ifJ-pyrazol-4-yl)-2-rnethyl-211-tetrazole 63 Cl CM3 (C113)2CH 5-[5-chloro-1-(2-methylpropyl)-1H-pyrazol-4- ______ ___________ CH2 yl] -2 -methyl-2 I-I-tetrazol e 64 Cl Cu3 CII2Ph 5-(1-benzyl-5-cliloro-1H-pyrazol-4-yl)-2- __________ _____ ____________ _____________ methyl-2H-tetrazole Cl CH3 C6H5 5-(5-chloro-1-phenyl-IJJ-pyrazol-4-yI)-2- _________ _____ ___________ ____________ methyl-2H-tetrazole 66 Cl CH3 2 CIC6H4 5-[5-chloro-i-(2-chlorophenyl)-1H-pyrazol-4- _________ _____ ___________ ____________ yl]-2-methyl-2J1-tetrazole 67 Cl CH3 3 Cl C6H4 5-[5-chloro-1-(3-chlorophenyl)-1H-pyrazol-4-yl]-2-rnethyl-2H-teirazole 68 Cl CU3 4 Cl C61-14 5-[5-chloro-1-(4-chlorophenyl)-lff-pyrazol-4- __________ _____ ____________ _____________ yl]-2-methyl-211-tctrazolc 69 Cl CH3 2,3C12C6H3 5-[5-chloro-1 -(2,3-dichlorophenyl)-lIJ-pyrazol-4-yI]-2-methyl-2H-tetrazo Ic Cl CM3 2,4C12C6T-13 5-[5-ehloro-l-(2,4-dichlorophcnyl)-1H- _________ _____ ___________ ____________ pyrazol-4-ylj-2-methyl-2H-tetrazole 71 Cl CH3 2.5C12C6H3 5-[5-chloro-1-(2,5-dichlorophcnyl)-1JJ- _________ _____ __________ ___________ pyrazol-4-yll-2-methyl-2H-tetrazole 72 Cl CM3 2.6C12C6H3 5-[5-chloro-1 -(2,6-dichlorophenyl)-l II-pyrazol-4-yl]-2-methyl-2H-tetrazole 73 CI CH3 3,4C12C61-13 5-{5-chloro-1-(3,4-dichlorophenyi)-1H-pyrazol-4-yl]-2-methyl-211-ietrazole 74 Cl CR3 3,5C12C6113 5-[5-chloro-1-(3,3-dicHorophenyl)-IH-pyrazol-4-yI]-2-methyl-2 Ti-tetrazole Cl Cu3 2 I3rC5H4 5-[l-(2-bromophenyl)-5-ch!oro-IJ-[-pyrazol-4-yfl-2-rnethyh2H-tetrazole 76 CI CH3 3 Br C6H4 5-[l-(3-hromophenyl)-5-chloro-1H-pyrazol-4-yfl-2-rnethyl-211-tctrazole 77 CI CT-I3 4 Br C6H4 5-[1-(4-broinophenyl)-5-chloro-1 JT-pyrazol-4- __________ _____ ____________ ___________ yl] -2-rnethyl-2H-tetrazole 78 Cl CH3 4 F C6H1 5-[5-chloro-l-(4-fluorophcnyl)-1JI-pvrazol-4-yl]-2-rncthyl-211-tetrazok 79 Cl CH3 2 F C6]J4 -5-[5.-chloro-l-(2-fluorophenyl)-IH-pyrazol-4-yl] -2-methyl-2H-tetrazole Cl CH3 2,3(CIJ3),C 5-[5-chloro-l-(2,3-dirnethylphenyl)-lff- 6H3 pyrazol-4-ylj-2-rnethyl-2H-tetrazole 81 -C CH3 2,4(C113h 5-[5-chloro-1 -(2,4-dimethyiphenyl)-111-C6113 pyrazol-4-yI]-2-rnethyl-2H-tetrazole 82 CI CR3 2,5(0-13)2 5-[5-ehloro-I -(2.5-dimethylphenyl)-1H-C6H3 pyrazol-4-yI]-2-rnethyl-2H1etrazole 83 Cl CIT3 2,6(CH3)2 5-[5-chloro-l-(2,6-dirnethylphcnyl)-IJJ-C6H3 pvrazol-4-ylj-2-methyl-2H-tetrazole 84 Cl CII3 3,4(CI-l3)2 5-[5-ehloro-1-(3,4-dimethylphenyl)-1 [I-C6H3 pyrazol-4-yI]-2-mcthyl -2H-tetrazole Cl Cl-I3 3.5(C113)1, 5-[5-ehloro-1 -(15-dirnethylphenyl)-IH-C6H3 pyrazol-4-yl]-2-rncthyl-2H-tetrazole 86 Cl CIT1 2CH2CH3C 5-[5-ehloro-l-(2-ethylphenyl)-I H-pyrazol-4-oIl4 yl] -2-mcthyl-21Hf-tetrazole 87 Cl CIT3 -4CH2CH3C 5-[5-chioro-l-(4-ethylphenyl)-1H-pyrazol-4-yI]-2-methyl-2H-teirazole 88 CI CR3 4 5-[5-chloro-l-(4-rnethoxyphenyl)-1H-pyrazol- __________ OCT-13C61-14 4-yl] -2-rnethyl-2H-tetrazole 89 Cl CH3 2C113C6114 5-[5-chloro-1 -(2-rnethylphenyl)-IH-pyrazol-4-yl]-2-methyl-211-tetrazole Cl CH3 4 CH3C6H 5-[5-chloro-1-(4-methvlphenyl)-IH-pyrazol-4-yl]-2-methyl-2H-tetrazole 91 Cl CH2CH3 CH3 5-(5-ehloro-l-rnethyl-IH-pyrazol-4-yl)-2-ethyl-2H-tetrazole 92 Cl CH2CH3 CH2CH3 5-(5-chloro-l-ethyl-1H-pyrazol-4-yl)-2-ethyl- 211-tetrazo Ic 93 CI CH2CH3 (CH3)2CH 5-[5-chloro-1-(2-rnethylpropyl)-1H-pyrazol-4-CR2 yl]-2-ethyl-2H-tetrazole 94 Cl CFI2CH3 CH2Ph 5-(1-henzyl-5-chloro-IH-pyrazol-4-yl)-2-ethyl-211-tctrazole Cl CH2CI-13 C6H5 5-(5-chloro-1 -phenyl-lII-pyrazol-4-yL)-2-elf yl-21J-tetrazole 96 Cl CH2CH3 2 C1C6114 5-[5-ehloro-]-(2-chlorophenyl)-1H-pyrazol-4-yl] -2-ethyl-211-tetrazole 97 Cl C112C113 3 Cl C6H4 545-ehloro-1-(3-chloroplienyl)-1II-pyrazol-4-yl] -2-ethyl--21J-tetrazole 98 Cl CH2CH3 4 Cl C6H, --5-[5-ehloro-1-(4-chlorophenyl,)-1II-pyrazo!-4-yl] -2-ethyl-2H-letrazole 99 Cl CH2CI-13 2,3 Cl2 5-[5-cHoro-1-(2,3-dichlorophenyl)-1H-C6H3 pyrazol-4-yl]-2-ethyl -2H-tetrazole Cl CH2CH3 2,4 Cl2 5-[5-chloro-1-(2,4-dich!orophenyl)-1 ii-C6H3 pyrazol-4-yl]-2-ethyl-211-tetrazolc 101 Cl CH2CH3 2,5 Cl2 5-[5-chloro-l-(2,5-dichlorophenyl)-IH-C6H3 pyrazol-4-yl]-2-ethyl-2H-tetrazole 102 Cl CH2CH3 2,6 Cl2 5-[5-eh]oro-1-(2,6-dichlorophenyl)-1H-C61-13 pyrazol-4-yl]-2-ethyl-2H-tetrazole 103 Cl CH2CI-T3 3,4 Cl2 5-[5-chloro-1 -(3,4-dich1oropbeny-1 /1-C6H3 pyrazol-4-yl]-2-ethyl-211-tetrazole 104 Cl CH7CH3 3,5 Cl2 -5-[5-chloro-1-(,5-dicblorophenyl)-l LI-C61-13 pvrazol-4-yfl-2-ethyl-2JT-tetrazole ibs Cl CH2CR 2 Br C6H4 5-[1-(2-brornophenyl)-5-chloro-1H-pyrazol-4-yl] -2-ethyl-2H-tetrazole 106 Cl C112C113 3 Br C6H4 5-[1-(3-brornophenyl)-5-chloro-1H-pyrazol-4-yl] -2-ethyl-211-tetrazo!e 107 Cl C1-T2CH3 4 Br C61-14 S-[1-(4-bromophenyl)-5-chloro-IH-pvrazol-4-ylj -2-ethyl-211-tetrazole 108 Cl C1-12C1-13 4 F C5l-14 5-5ch1oro-1-(4-iluorophenyl)-lH-pyrazo!-4-yI]-2-ethyl -2F1-tetrazole 109 Ci CFbCHJ 2 F C5H4 5-[5-chloro-1-(2-fluorophenyl)-IH-pyrazol-4-yl]-2-ethyl-211-tetrazole Cl CT-12CH3 2.3(CH3)2 5-[5-chloro-1-(2,3-dimethylphenyi)-1H-C6H3 pyrazol-4-yI]-2-ethyl-2H-tetrazole 111 Cl CH2CI-13 2.4(CH3)2 5-[5-chloro-1 -(2,4-dimethyiphenyl)-i if-C6H3 pyrazol-4-yl]-2-ethyl-2H-tetrazole 112 Cl CH2CH3 2,5(CH3)2 5-[5-ehloro-1 -(2.5-dimethylphenyl)-1H-C5H3 pyrazol-4-yl]-2-ethyl-2H-tetrazole TiTI Cl CH2CI-13 2,6(C1-102 5-[5-chloro-I-(2,6-dimethylphenyl).-IH.-C6F13 pyrazol-4-yl]-2-ethyl-2H-tetrazole 114 Cl CH2CH3 3,4(CH3) 5-[5 ch1oro-1 -@ ,4-dimethylphenyl)-1 H-C6H3 pyrazol-4-yl]-2-ethyl-2f1-tetrazole Cl CFI2CII3 3,5(CFI3)2 5-[5-chloro-1-(3,5-dimethylphenyl)-1H-C5F13 pyrazol-4-yl]-2-ethyl-2H-tetrazole 116 Cl CH2CH3 2CH2CH3C 5-[5-ehloro-1-(2-ethylphenyl)-1H-pyrazol-4-yl]-2-cthyl-21/-tctrazol c 117 Cl CH2CI-T3 4CH2CH3C 5-[5-chloro-1-(4-ethylphenyl)-IH--pvrazol-4-yl]-2-ethyl-21/-tctrazolc 118 Cl CH2CH3 4 5-[5-ehloro-1-(4-mcthoxyphcnyl)-IJf-pyrazol-OCT 13C5T14 4-yl] -2-ethyl-2H-tetrazole 119 Cl CT-12CH3 2CH3C6114 5-[5-chloro-1-(2-methylphenyl)-TH-pyrazol-4-yl] -2-ethyl-2H-letrazole Cl CH2C [13 4CH3C6H4 545-ehioro-1 -(4-methyiphenyl)-IH-pyrazol-4-yI]-2-ethyi-211-tetrazole 121 Cl CH(CH3)2 CH3 5-(5-ehloro-I -methyl-I JJ-pyrazol-4-yI)-2-(I -methylethyl)-2H-tetrazole 122 Cl CI-I(CH3)2 CH2CII3 5-(5-chloro-1-ethyl-1H-pyrazo1-4-y-2-( 1-rnethylethyl)-2H-tetrazole 123 Cl CIi(CIT3)2 (CTT3)2CTT 5-5-ch1oro-I-(2-mcthylpropy1)-1H-pyrazo1-4-Cl-I2 yl]-2-(l -methylethyl)-2H-tetrazole 124 Cl CH(CH3)2 CH2Ph 5-(1-benzyl-5-eHoro-I H-pyrazol-4-yI)-2-(i -rnethylethyl)-2f1-tetrazole Cl CH( H3)2 C5H5 5-(5-chloro-1 -phenyl-1 iJ-pyrazoI-4-y-241 -methylethyl)-2H-tetrazole 126 Cl CH(CH3)2 2 C1C6H4 5 -[5 -cbloro-I -(2-clilorophenyl)-1iI-pyrazol-4-ylI-2-(1 -methylethyl)-2H-tetrazole 127 Cl CH(Cl-l3)2 3 Cl C6H4 5-[5-cbloro-l-(3-ehlorophenyl)-IH-pyrazol-4-Y1I-2-O -rnethylethvL)-2H-teixazole 128 Cl CH(CH3)2 4 Cl C6H4 5-[5-ehloro-I-(4-chlorophenyl)-i//-pyrazol-4-ylI-2-(1 -rnethylethyl)-2H-tetrazole 129 Cl CII(CTJ3)2 2,3 Cl2 5-[5-chloro-I-(2,3-diehlorophenyl)-TH-C51-l3 pyrazo] -4-yl]-2-(l -rnethylethyl)-2H-tetrazole Cl CH(CH3)2 2,4 Cl2 5-[5-cbloro-I-(2,4-diehlorophcnyl)-1JI-C6T-T3 pyrazol-4-yl]-2-( 1 -methylethyl)-2H-tetrazole 131 Cl CH(CT-13)2 2,5 Cl2 5-[5-chloro-I-(2,5-diehlorophenyl)-1H-pyrazol -4-yI]-2-(l -mcthylcthyl)-211-tetrazolc 132 Cl CH(CH3)2 2,6 Cl2 5-15-chloro-1-(2,6-dichlorophenyl)-1H-C6H3 pyrazol-4-yI]-2-(1 -methylethyl)-2H-tetrazole 133 Cl C1-1(CH3)2 3,4 Cl2 5-[5-chloro-1-(3,4-dieHoropheiM)-l//-C6H3 pyrazol-4-yl]-2-( 1 -rnethylcthyl)-2H-tctrazole 134 Cl CH(CH3)2 3,5 Cl2 5-[5-ehloro-l-(3,5-dichlorophenyl)-1H-C6H3 pyrazol-4-yl]-2-(l -rnethylethyl)-2H-tetrazole Cl CH(C1-13)2 2 Br C6H4 5-[1-(2-bromophenyl)-5-ehloro-1 [T-pyrazol-4-yl] -2-( 1 -methylethyl)-2H-tetrazole 136 CI CH(CH3)2 3 Br C6114 5-[1-(3-brornophenyl)-5-c.hloro-1JT-pyrazol-4-yl]-2-(1 -methylethy-2H-tetrazo1e 137 Cl CH(CI-13)2 4 Br C6H4 5 -[1 -(4-bromopheuyl)-5 -chioro-1H-pyrazol-4-yl]-2-(l -methylethyl)-2H-tetrazole 138 Cl CII(C113)2 4F C6R1 5-[5-ehloro-i-(4-iluorophenyl)-1H-pyrazol-4-yl] -2-( I -rnethylcthyl)-2H-tetrazole 139 Cl CH(CH3)2 2 F C6H4 5-[5-chloro-1-(2-fluorophcnyl)-1iI-pyrazol-4-yl]-2-(l -rnethylcthyl)-2H-tetrazole Cl CH(CH)2 2,3(CH3)2 5-{5-chloro-1-(2,3-dimethylphenyl)-1II-C6H3 pyrazol -4-yl]-2-(l -methylethyl)-2H-tetrazole 141 Cl C1-1(CI-13)2 2,4(CI-13)2 5-[5-ehloro-l-(2, 4-dirnethylphenyl)-1H-C61-13 pyrazol-4-yl]-2-(1 -methylcthyl)-2//-tetrazole 142 Cl CII(CIh)2 2,5(CH3)2 5-[5-chloro-1-(2,5-dirnethyiphenyi)-1fI-C51 13 pyrazol-4-yl]-2-( I -rnethylethyl)-2H-tetrazole 143 Cl Cl-1(CH3)2 2,6(C113)25-[5-chloro-l-(2,6-dimethylphenvl)-1JI-C6H3 pyrazol-4-yfl-2-( I -methylethyl)-2H-tetrazolc 144 Cl CH(CH3)2 3,4(CH3)2 5-[5-chloro-1-(3,4-dimethylphenyl)-1fI-C6H3 pyrazol-4-yl]-2-( 1 -rneihylethyl)-2H-tetrazole Cl CFI(C113)2 3,5(C113)2 5-[5-ehloro--(3,5-dirnethylphenyl)-1H-C61-13 pyrazol-4-yl]-2-( I -methylethyl)-2H-tetrazole 146 Cl CH(CH3)2 2C1-12C113 5-[5-ch1oro-1-(-ethylphcny1)-1fI-pyrazoI-4-C6H4 ylf-2-(l -methylethyl)-2H-tetrazolc 147 CI CH(CH3)2 4C1-12CH3 5-[5-ebloro-1 -(4-ethyiphenyl)-1 H-pyrazol-4-C5H4 ylj-2-(ll -rnethylethyl)-2H-tetrazole 148 Cl CH(CH3)2 4 5-15 -chloro-I -(4-methoxyphenyl)-I Il-p yrazol-OCH3C6FL1 1-yl] -2-( 1 -rnethylethyl)-211-tetrazolc 149 Cl CH(CH3)2 2CR3C6H4 5-[5-chloro-1-(2-rnethylphenyl)-1H-pyrazol-4-yl] -2-0 -rnethylethyl)-211-tetrazole Cl CH(CH3)2 4C1-13C6H4 5_[5:chloro_1(4_methylphenyl)_1JI_pyrazo1_4 yl]-2-(l -rnethylethyl)-2H-tetrazole 151 Cl C112C6115 CIT3 2-benzyl-5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2H-tetrazole 152 CI CH2C6H5 CFI2CH3 2-benzy1-5-(5-ch[oro--ethy1-1JI-pyTazol-4-yl)-211-tctrazolc 153 Cl C112C6H5 (C113)2C11 2-benzyl-5-[5-chloro-l-(2-methylpropyl)-1H-CH2 pyrazol-4-yl]-2H-tetrazole 154 CI Cl-12C6H5 CI-l2Ph 2-hcnzyl-5-(1-bcnzyl-5-ehloro-l/I-pyrazol-4-yl)-2H-tetrazole Cl CH2C6H5 C6H5 2-benzyl-5-(5-chloro-1-phenyl-1H-pyrazol-4-yl)-2H-tetrazole 156 Cl CH2C6H5 2 C1C61-l 2-henzyl-5-[5-ch1oro-1-(2-cHorophcny-1FJ-pyrazol-4-yfl-2H-tetrazole 157 Cl CH2C6H5 3 Cl C61-14 2-benzyl-5-[5-chloro-1-(3-cblorophenyl)-TH-pyrazol-4-ylj-2H-tetrazole 158 CI CH2C6H5 4 C C6H 2-benzyl-5-[5-chloro-i-(4-cHorophenyl)-IH-pyrazo!-4-yI]-2H-tetrazole 59 CI CH2C6H5 2,3 C2 2-benzy1-5-[5-choro-1-(2.3-dic1iiorophcnyl)-C6113 I H-pyrazol-4-yl] -2H-tetrazole Cl CH2C6H5 2,4 Cl2 2-benzyl-5-[5-chloro-1-(2,4-dichlorophenyl)-Cj-13 IH-pyrazol-4-yl]-2H-tetrazole 161 Cl CH2C6H 2,5 Cl2 2-bcnzyl-5-[5-chloro-1-(2,5-dichlorophenyl)-C61 13 1H-pyrazol-4-yfl-2H-tetrazole 162 Cl CH2C6H5 2,6 02 2-benzyl-5-[5-chloro-1-(2,6 -dichiorophenyl)-C6H3 IH-pyrazol-4-yl]-2H-tetrazole 163 0 CH2C6H5 3,4 Cl2 2-benzyI-5-[5-chIoro-1-(3,4-dich!oropheny-C5H3 I H-pyrazol-4-yl]-2H-tetrazole 164 Cl CH2C6FI5 3,5 Cl2 2-benzyl-5-[5-chioro-1 -(3,5-dichlorophenyl)-C413 1H-pyrazol-4-yl]-2H-tetrazole Cl C1-12C6H5 2 Br C6H4 2-benzyl-5-[1-(2-bromophenyl)-5-chloro-1H-pyrao1-4-y1]-2H-tetrazo1e 166 Cl CH2C6H5 3 Br C6H4 2-benzyl-5-[ 1 -(3-brornophenyl)-5-chloro-1H-pyrazol-4-yI]-2//-tetrazole 167 Cl CH2C6FI3 4 Br C61I4 2-benzyl-5-[ I -(4-bromopheny-5 -chioro-1H-pyrazol-4-yl]-2H-tetrazole 168 Cl CH2C5H5 4 F C6H4 2-bcnzyl-5-[5-cbloro-l-(4-fluorophenyl)-1JI-pyrazol-4-yl]-2H-tetrazole 169 Cl CH2C5H5 2 F C6H4 2-benzyl-5-[5 -chloro-I -(2-fluorophenyl)-1H-pyrazol-4-yI]-2//-tetrazole Cl CH2C6HS 2,3(CH3)2 2-benzyl-5.-[5-chloro-1-(2,3-dimethylphenyl)-C6H3 1H-pyrazol-4-yl]-2H-tetrazole 171 Cl CH2C6HS 2,4(CII 2-henzyl-5-[5-ch!oro-I -(2,4-dirnethylphenyl)-C6113 1 H-pTazo1-4-y1]-2II-tctrazo1e 172 Cl CH2C5H5 2,5(H3)2 2-benzvi-5-[5-ehloro-1-(2.5-dirnethylphenyl)-C6H3 1II-pyrazol-4-yl]-2H-tetrazole 173 Cl CH2C6H5 2,6(C113)7 2-benzyl-5-[5-chloro-I -(2,6-dimcthylphenyl)-C6H3 1 H-pyrazol-4-yl]-2H-tetrazole 174 Cl CH2C5F-I5 3,4(CH3)2 2-benzyl-5-[5-ehIoro-1-(3,4-dimeLhylphenyl)-C6H3 1H-pyrazol-4-yI]-2H-tetrazole CI CH2CJ-15 3,5(C113)2 2-benzyl-5-[5-ehloro-1-(3.5-dirnethylphenyl)-C5H3 1 H-pyrazol-4-yl]-2H-tetrazole 176 Cl CH2C6H5 2CH2CH3 2-benzyl-5-[S-ehloro-1 -(2-ethyiphenyl)-1H-C61-14 pyrazol -4-yl] -2H-tetrazole 177 Cl CH2CÔH5 4C1 12C1 I 2-henzyl-5-[5-oh loro-I -(4-ethylphenyl)-1 H-C6H4 pyrazol-4-vl]-2H-tetrazo Ic 178 CI CE-12C6E15 4 2-benzyl-5-[5-chioro-1 -(4-methoxyphonyl)-OCH3C6H4 1 ff-pyrazol-4-yl]-2H-tetrazole 179 Cl C112C6H5 2 CH3C6H4 2-benzyl-5-[5-ehloro-1-(2-methylphenyl)-IH-pyrazol-4-yI] -21-I-tetrazol c CI CH,C6H5 4CH3C611L1 2-benzvl-5-[5-ohloro-1-(4-methylphenyl)-IH-pyrazol -4 -yl]-2 [I-tetrazol 181 Cl -4BrC6H4 CH3 2-(4-bromobcnzyl)-5-(5-ohloro-1-methyl-1H-Cl-I2 pyrazol-4-vI)-2H-tetrazole 182 Cl 4BrC6H4 CH2CH3 2-(4-bromobenzyl)-5-(5-ehloro-1-ethyl-I H-CM2 pyrazol-4-yl)-2H-tetrazole 183 CI 4BrC6H4 (CH3)2CH 2-(4-bromobenzyl)-5-[5-ohloro-1-(2-CM2 CH2 methylpropyl)-1!-I-pyrazol-4-yl] -2H-tetrazole 184 Cl 4BrC6T-T4 C1-T2Ph 5-( I -hcnzyl-5-ehloro-1J1-pyrazol-4-yl)-2-(4-CI 12 hromobenzyl)-2JJ-tctrazole Cl 4BrC6H4 C6F15 2-(4-bromobenzyl)-5-(5-ohloro-1 -phony!-111-CM2 pyrazol-4-yl)-2H-tetrazole 186 Cl 4BrC6H4 2 C1C5I-14 2-(4-brornobenzyl)-5-[5-ohloro-l-(2-CM2 chiorophenyl)-1H-pyrazol-4-yI]-211-tctrazolc 187 Cl 4BrC6H4 3 CI C6H4 2-(4-hromobenzyl)-5-[5-chloro-1-(3-CM2 ch lorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole 188 Cl 4BrC6H4 4 Cl C6114 2-(4-bromobenzyl)-5-[5-chloro-1 -(4-C H2 chiorophenyl)-1H-pyrazol-4-yfl-2H-tetrazole 189 C] 4BrC6H4 2,3 Cl2 2-(4-bromobenzyl)-5-[5-chloro-1-(2,3-CH2 C6H3 dichiorophenyl)-I TJ-pyrazol-4-yl]-2H-tetrazole -Cl 4BrC61I4 2,4 Cl2 2-(4-broniobenzyl)-5-[5-chloro-1-(2,4-CH2 C6H3 dichiorophenyl)-1H-pyrazol-4-yll-2H-tetrazole 91 Cl 4BrC6H4 2,5 Cl2 2-(4-bromobenzyl)-5-[5-chloro-1-(2,5-CH2 C6H3 dichloropheny!)-1 JJ-pyrazol-4-yl]-2/f-tetrazole 192 Cl 4BrCH4 2,6 Cl2 2-(4-bromobenzyl)-5-[5-chloro-1-(2,6-CH2 C6H3 dichiorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole 193 Cl 4BrC6II4 3,4 Cl2 2-(4-hromobenzyl)-5-[5-chloro-1-(3,4-CR2 Cl-I3 diehiorophenyl)-1 H-pyrazol-4-yll -21-I-tetrazole 194 Cl 4BrC6H4 3,5 Cl2 2-(4-brornobenzyl)-5-[5-chloro-1-(3,5-CH2 C5H3 diehiorophenyl)-IH-pyrazol-4-yl] -2H-tetrazole Cl 4BrC6H4 2 Br C6H4 2-(4-broniohenzyl}-5-[1 -(2-bromophenyl)-5-CR2 chioro-1II-pyrazol-4-ylJ-211-tetrazolc 196 Cl 4BrC61T4 3 Br C6T-14 2-(4-hromohenzyl)-5-[1 -(3-hromophenyl)-5-CIT7 chioro-1H-pyrazol-4-yll-2H-tetrazole 197 Cl 4BrC6H4 4 Br CH4 2-(4-bromobenzyl)-5-[ 1 -(4-brornophenyl)-5-CM2 chioro-IH-pyrazol-4-yl] -2H-tetrazole 198 CI 4BrC6H4 4 F C6H4 2-(4-brornohenzyl)-5-[5-chloro-1-(4-CH2 fluorophenyl)-lH-pyrazol-4-yl]-2H-tetrazole 199 Cl 4BrC6H4 2 F C6H4 2-(4-bromobenzyl)-5-[5-chloro-l-(2-CH2 fluorophenyl)-I JI-pyrazol -4-yl] -211-tctrazole CL 4BrC5fI4 2,3(C113)2 -2-(4-bromobcnzyl)-5-[5-chloro-l-(2,3- CM2 C6H3 dirnethyiphenyl)-1 H-pyrazol-4-ylj -2H- ____________ _____________ tetrazole 201 CI 4BrC5H4 2,4(CH3)2 2-(4-bromobenzyl)-5-[5-chloro-1-(2,4- CM2 C6H3 dimethylphenyl)-1 H-pyrazol-4-ylI -2H-tetrazole 202 Cl 4BrC6H4 2,5(CH3)2 2-(4-brornobenzyl)-5-[5-chloro-1-(2,5- CM2 C61-13 dimethylphenyl)-I H-pyrazol -4-yl] -2H-tetrazole 203 Cl 4BrC6M4 2,6(CH3)2 2-(4-brornobenzyi)-5 -[5 -chloro-1 -(2,6- Cl-I2 C6H3 dimethyIpheny-I TJ-pyrazol-4-yI]-211-tetrazole 204 Cl 4BrC6M4 3,4(CT-T3)2 2-(4-bromohenzyl)-5-[5-chloro-I-(3,4- CR2 C61T3 dimcthylphcnyl)-1H-pyrazol-4-yl]-2H-t.etrazole 205 Cl 4BrC6ftj 3,5(CH3)2 2-(4-hromobenzvl)-5-[S-chloro-1-(3,5- CR2 C6H3 dimethylphenyl)-1H-pyrazol-4-ylj-2H-tetrazole 206 Cl 4BrC6H4 2CM2CH3 2-(4-bromobenzyl)-5-[5-chloro-1-(2-CR2 C6FI ethylphenyl)-1 H-pyTazol-4-ylj-2H-tetrazole 207 Cl 4BrC5M4 4CH2CR3 2-(4-bromobenzyl)-5-[5 -chioro-1 -(4-CR2 C6H4 ethylphenyl)-I TJ-pyrazol-4-yl]-2H-tetrazole 208 Cl 4BrC6H4 4 2-(-bromobcnzyl)-5-[5-ch1oro-1-(4- CI 12 OCI 13C6114 methoxyphenyl)-1H-pyrazol-4-yl]-211-tetrazole 209 Cl 4BrC414 2 C1-I3C6H4 2-(4-hromohenzyl)-5-[5-chloro-1-(2-Cl-I2 methyiphenyl)-1H-pyrazol-4-yfl-2H-tetrazole 210 CI 413rC6H. 4 CH3C6H 2-(4-broniobenzyl)-5-5-ch1oro--l -(4-CI 2 methylphenyl)-I H-pyrazol -4-yI]-211-tetrazole 2 Cl 4CNC6H4 CH3 4-[ [5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-C H2 2[f-tetrazol-2-yljrnethyl}benzonitrile 212 Cl 4CNC5FI4 CR2CH3 4-([5-(5-chloro-l-ethyl-IH-pyrazol-4-yl)-2H-CH2 tetrazol-2-yl]rnethyl}henzonitril c 213 Cl 4CNC6II4 (C113)2C11 4-G5-15-chloro-1 -(2-methylpropyl)-1 H- CH2 CR2 pyrazol-4-yl]-2H-tetrazol-2- __________ _____ ____________ _____________ yl}methyl)benzonitrile 214 Cl 4CNC5H4 CH2Ph 4-{ [5-(1 -benzyl-5-chloro-I H-pyrazol-4-yI)-CR2 211-tetrazol-2-yljmethyl} benzonitrilc 215 Cl 4CNC6FI4 C415 4-( [5-(5-chloro-1 -phenyl-1H-pyrazol-4-yl)-CH2 2H-tetrazol-2-yl]methyl}benzonilrile 216 Cl 4CNC6H4 2 C1C6H4 4-(5-[5-ch1oro-I -(2-ehlorophcnyl)-ill- Cl-I2 pyrazol-4-yl]-2H-tetrazol-2- _________ _______________ yl} methyl)benzonitrile 217 Cl 4CNC6114 3 Cl C6F1 4-({5-[5-chloro-1-(3-chloropheny[)-1H- CR2 pyrazol-4-yl]-2H-tetrazol-2- ___________ ______ _____________ _____________ yl} methyl)benzonitrile 218 Cl 4CNC6M 4 Cl C6R4 4-({5-[5-chloro-1 -(4-chlorophenvl)-1 H- CM2 pyrazol-4-yl]-211-tctrazol-2- _________ _____ ___________ ____________ yl}methyl)benzonitrile 219 Cl 4CNC6H4 2,3 Cl2 4-({5-[5-chloro-1-(2,3-dichlorophenyl)-1H- CM2 C5H3 pyrazol-4-yl]-21[-tctrazol-2- _________ _____ ___________ ____________ yl}methyl)henzonitrile 220 Cl 4CNC6H4 2,4 Cl2 4-({5-[5-chloro-1-(2,4-dichlorophenyl)-1H- CM2 C5H3 pyrazol-4-ylj-2H-tctrazol-2- _________ _____ ___________ ____________ yl} methyhenzonitri Le 221 Cl 4CNC6H4 2,5 Cl2 4-({5-[5-chloro-1 -(2,5-dichlorophenyl)-1H- Cl-I2 C6H3 pyrazol-4-yl J-2K-tetrazol -2- ___________ ______ _____________ _____________ yl} methyl)benzonitrile 222 CI 4CNC6H4 2,6 CE2 4-({5-[5-chloro-I -(2,6-dichlorophenyl)-1 H- CM2 C6M3 pTazo1-4-y1]-2II-tctrazo1-2- ___________ ______ _____________ _____________ yl}methyl)benzonitrile 223 Cl 4CNC6H4 3,4 Cl2 4-( (5-[5-chloro-1 -@ ,4-dichlorophcnyl)-111- CI 12 C61 13 pyrazol-4-yll-2H-tetrazol-2- __________ _____ yl}rnethyl)benzonitrile 224 CI 4CNC6I-14 3,5 Cl2 4-({5-[5-chloro-I -(3,5-dichiorophenyl)-111- CM2 C6M3 pyrazol-4-yll-2H-tetrazol-2-yl}methy)benzonitri1e 225 Cl 4CNC5I-T4 2 Br C6H4 4-({5-[5-chloro-I -(2-bromophenyl)-H- CIT2 pyrazol-4-yI]-2H-tetrazol-2- ___________ ______ _____________ _____________ yl} rnethy)benzonitri1e 226 Cl 4CNC6H4 3 Br C6H4 4-({5-[5-chloro-I -(3-hromopheny!)-1H- CR2 pyrazol-4-yl]-2H-tetrazol-2- ___________ ______ _____________ _____________ yl}rnethyl)benzonitrile _____________________ 227 Cl 4CNC6H4 4 Br C61-14 4-({5-[5-chloro-1-(4-broinophenyl)-1H- CR2 pyrazol-4-yl]-2H-telrazol-2- __________ _____ ____________ _____________ yl}rnethyl)henzonitrile 228 Cl 4CNC6IT4 4 F C6114 4-({5-iS-chloro-1-(4-lluorophenyl)-1H- CH2 pyrazol-4-ylj-2H-tetrazol-2-yI}methyl)henzonitrile _____________ 229 Cl 4CNC6II4 2 F C6IL 4-({5-15-chloro-1-(2-tluorophenyl)-IH- CH2 pyrazol-4-yli-2H-tetrazol-2- ____________ ______ ______________ _______________ yI}rneuyl)benzoniu-ile _____________ 230 Cl 4CNC6I-14 2,3 (CR3)2 4-({5-[5-chloro-I -(2,3-dimethylphenyl)-1H- CIT2 C6I13 pvrazol-4-yfl-2H-tetrazol-2- __________ _____ ____________ _____________ yl} methyl)benzonitrile 231 Cl 4CNC6F-]4 2,4 CH3)2 4-({5-[5-chloro-1-(2,4-dimethylphenyl)-IH- Cu2 C61 13 pyrazol-4-yl]-2H-tetrazol-2- __________ _____ ____________ ___________ yl}methyl)benzonitrile __________________ 232 CI 4O'C6H4 2,5 (CIT3)2 4-({5-[5-cffloro-1 -(2,3-dimcthylphcnyl)-1H- CM2 C4H3 pyrazol-4-yfl-2H-tetrazol-2- ____________ _______ ________ yl}n1ethvl)benzonitrile 233 Cl 4CNC6114 2,6 (CIT3)2 4-({5-[5-chloro-1 -(2,6-dirnethyiphenyl)-I 11- CM2 C6H3 pyrazoi-4-yl]-2H-tetrazol-2- ___________ ______ _____ _____ yl}methyl)henzonitrile 234 0 4NC5I-14 3,4 (CIT3)2 4-({ 5-{5-chloro-1 -(3.4-dimethyiphenyl)-TH- Cl-I2 C6H3 pyrazol-4-ylj-2H-tetrazol-2- __________ ______ ____________ _______ yl}rnethyl)benzonitrile 235 Cl 4CNC5I-14 3,5(C113)2 4-({5-[5-chloro-1 -(3,5-dimethyiphenyl)-1H- CT-I2 C6H3 pyrazol-4-yl]-2H-tetrazol-2- ___________ ______ _____________ ______________ yl}rnethyl)benzonitrile 236 Cl 4CNC6H.4 2CH2CM3 4-({5-[5-chloro-I -(2-ethylphenyl)-1 H-pyrazol-CH2 CIT4 4-yli -2H-tctrazol-2-yl} methyl)bcnzonitrile 237 Cl 4CNC6H4 4CH2CH3 4-({5-[5-chloro-T-(4-ethylphenyl)-IH-pyrazol-CI 12 C6114 4-yl] -2H-tetrazol-2-yl}rnethyl)benzonitrile 238 Cl 4CNC6H4 4 4-({5-{5-chloro-I -(4-methoxyphenyl)-1H----- CM2 OCT 13 C61 L pyrazol-4-yl]-2H-tetrazol-2- ___________ ______ _____________ ______________ yl}methyl)benzonitrile ____________ 239 CI 4CNC6R4 2 CIT3C6I 14 4-( {5-Is -chloro-1 -(2-methylphenyl)-iN- CR2 pyrazol-4-yl]-2H-tetrazol-2- ______ ______________ _______________ yl}methyl)henzonitrilc 240 Cl 4CNC6FI4 4 CH3C6H4 4-({5-[5-chloro-1-(4-methylphenyl)-1H- Cu2 pyrazol-4-ylj-2H-tetrazol-2- _______ ___--________ yI}rnethyl)henzonitrile _____________ 241 Cl 4CH30C6 CH3 5-(5-chloro-1-rnethyl-1H-pyrazol-4-yl)--2-(4-R4CH2 rncthoxybenzyl)-2 Tf-tetrazole 242 Cl 4C1130C6 C112C113 5-(5-chloro-1-ethyl-1H-pyrazol-4-yl)-2-(4- 1J14CH2 methoxybenzyl)-2H-tetra2ole 243 CL 4CH30C6 (CH3)2CH 5-[5-c.hloro-1-(2-methylpropyl)-1 JI-pyrazo!-4-H4CH2 CH2 yl] -2-(4-rnethoxybenzyl)-211-tctrazole 244 Cl 4C1-130C6 ClI2Ph 5-( 1 benzy1-5-ch1oro-1 H-pyrazol-4-yl)-2-(4- 1-14CH2 rnethoxybenzyl)-211-tetrazole 245 Cl 4CF130C5 C6115 5-(5-chloro-1-phenyl-1JI-pyrazol-4-yl)-2-(4-H4CH2 rnethoxybenzyl)-2H-tetrazole 246 Cl 4C1130C5 2 C1C5114 5-[5-chloro-l-(2-ehlorophenyl)-IH-pyrazol-4-H4CJ-12 ylj-2-(4-methoxybenzyl)-2H-tetrazole 247 Cl 4CH30 3 Ci C6T-14 5-[5-ehloro-1-(3-chlorophenyl)-IH-pyrazol-4-C6H4CH2 yI]-2-(4-methoxybenzyl)-2H-tetrazole 248 Cl 4C1-130 4 Cl C6T-14 5-[5-chloro-1-(4-chlorophenyl)-1H-pyrazol-4-CJ14C112 yli-2-(4-methoxybenzyl)-2H-tetrazole 249 Cl 4CF130 2,3C12C6113 5-[5-cliloro-1-(2,3-dichlorophenyl)-IH- C6114C112 pyrazol-4-ylj-2-(4-rnelhoxybenzyl)-2H- _________ tetrazole 250 Cl 4CH30 2,4C12C5111 5-[5-cliloro-1 -(2,4-diehiorophenyl)-IN- C6Ii4CH2 pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2J1-tetrazole 251 Cl 4CH30 2,5C12C5H3 5-[5-chloro-1 -(2,5-diehlorophenyl)-111- C6H4CH2 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole _______ 252 Cl 4CH30 2,6C12C6H3 5-[5-ehloro-l-(2,6-diehlorophenyl)-IH- C5H4CH2 pyrazol-4-yl]-2-(4--methoxyhenzyl)-2H-tetrazole 253 Cl 4CH30 3,4C12C6H3 5-[5-ehloro-1 -@ ,4-dichlorophenyl)-1H- C61 14C1 2 pyrazol-4-yl]-2-(4-rnethoxybenzyi)-211- ____________ ______ ______________ _______________ tetrazo I e __________________________________________ 254 Cl 4CH30 3,5C12C6H3 5-[5-chloro-1 -(3,5-dichlorophenyl)-1H- C6H4CT-T2 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole -___________ 255 Cl 4CH30 2 Br C6H4 5-[1-(2-hromophenyl)-5-chloro-1If-pyrazol-4-C6H4CI-12 yll-2-(4-methoxybenzyl)-2H-tetrazole 256 Cl 4C1-130 3 Br C6H4 5-fl -(3-bromophenyl)-5-ehloro-IH-pyrazol-4-C61-14C1-12 yll -2-(4-rncthoxybenzyl)-2H-tetrazole 257 Cl 4CH10 4 Br C6H4 541 -(4-bromophenyl)-5 -ehioro-1H-pyrazol-4-C6114C1-12 yl]-2-(4-rnethoxybenzyl)-2/-/-teira-zoie 258 Cl 4CH30 4 F C6H4 5-[5-chloro-1-(4-fluorophcnyl)-UJ-pyrazol-4-CJ-l4CH2 yl] -2-(4-methoxybenzyl)-2H-tetrazole 259 Cl 4C1I3O 2 F C61-14 5-[5-chloro-I-(2-fluorophenyl)-IH-pyTazol-4-C5H4CH2 yl] -2-(4-methoxybenzyl)-2H-tetrazole 260 Cl 4CF1iO 2.3(CFT1)2 5-[5-chloro-l-(2,3-dimethylphenyl)-1H- C6H4CH2 C6H3 pyrazol-4-y]]-2-(4-methoxyhenzyl)-211- _________ _____ ___________ ____________ tetrazole 261 Cl 4C1-130 2.4(CFI3)2 5-[5-chloro-1 -(2,4-dirnethyiphenyl)-1 H- C6H4CH2 C6H3 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole 262 Cl 4CH30 2,5(CH3)2 5-[5-ehloro-1-(2.5-dimethylphenyl)-TH- C6H4CH2 C5H3 pyrazol-4-ylj-2-(4-methoxybenzyl)-211-tetrazole 263 Cl 4CH30 2,6(H3)2 5-[5-ehloro-1 -(2,6-dimethyiphenyl)-Ill- C5144C112 C6W pyrazol-4-yfl-2-(4-rncthoxybenzyl)-2H-tetrazole 264 Cl 4C1-130 3,4(CH3)2 5-[5-chloro-1-(3,4-dimethylphenyl)-1 F-f- C6H4CH2 C6H3 pyrazol-4-yl]-2-(4-methoxybenzyl)-2J1- ____________ _____________ tetrazole 265 Cl 4C1130 3,5(C113)2 5-[5-chloro-1 -(3.5-dimethyiphenyl)-IH- C61-LCH2 C61-13 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H- __________ _____ ____________ _____________ tetrazole 266 Cl 4CF130 2C1-12CF13 5-[5-chloro-1-(2-ethylphenyl)-1H-pyrazol-4-C61-14CH2 C6H4 yl]-2-(4-rnethoxybenzvl)-2H-tetrazole 267 Cl 4CH30 4CH2CI-13 5-5-ch1oro-I -(4-ethylphe.nyl)-Jl-pyrazol-4-C6H4C H2 C6H4 yfl -2-(4-methoxybenzyl)-211-tetrazolc 268 Cl 4CE130 4 5-[5-chloro-1-(4-rnelhoxyphenyl)-IH-pyrazol-C6H4CH2 OCH3C6H4 4-yl]-2-(4-methoxybcnzyl)-211-tetrazole 269 Cl 4CH30 2 CH3C6H4 5-[5-ehloro-1 -(2-methylphenyl)-IH-pyrazol-4-C6l-lCl-T2 yl]-2-(4-methoxybenzyl)-2H-tetrazole 270 Cl 4CH30 4 CH3C6H 5-{5-chloro-1-(4-rnethylphenyl)-IH-pyrazol-4-C5H4CI-12 yll-2-(4-methoxybenzyl)-2H-tetrazole 271 Cl 3CH3C6H4 CH3 5-(5-ehloro-1 -methyl-H-pyrazol-4-yI)-2-(3-CH2 rnethylbenzyl)-2H-tetrazoIe 272 Cl 3CF13C6H4 CH2CH3 5-(5-ehloro-l -ethyl-I [J-pyrazol-4-yl)-2-(3-C I-t methyl henzyl)-2H-tetrazole 273 Cl 3CF13C6H4 (CH3)2CH 5-[S-chloro-l-(2-methylpropyl)-1H-pyrazol-4-CI 12 CIT2 yl]-2-(3 -methylbenzyl)-2H-tetrazole 274 Cl 3CH3C6T-L4 CI-T2Ph 5--benzyl-5-ehloro-I 1J-pyrazol-4-yl)-2-(3-CU2 methylbenzyl)-2H-tetrazole 275 Cl 3CH3C6H4 Ca5 5-(5-chloro-l-phenvl-1H-pyra2ol-4-yl)-2-(3-CH2 methylbenzyl)-211-tetrazole 276 Cl 3CH3C6H4 2 C1C6H4 5-[5-chloro-1-(2-chlorophcnyl)-1H-pyrazol-4-Cu2 yl] -2-(3-methylbenzyl)-2H-tetrazole log 277 Cl 3C113C6114 3 Cl C6H4 5-[5-chloro-1 -(3-ehlorophenyl)-I!i-pyrazoi-4-CH2 yl] -2-(3-methylbenzyl)-2H-tetrazole 278 CI 3CH3C6R,1 4 Ci C5H4 5-[5-ch1oro-l-(4-thloropheny)-lH-pyrazol-4-CIT2 yl]-2-(3-methylbenzvl)-21J-tetrazoie 279 Cl 3C1-13C6114 2,3 CU 5-[5-chloro-l-(2,3-dichlorophcnyl)-1II-C H C61-13 pyrazol-4-yl]-2-(3 -methylbenzyl)-2H-tetrazole 280 Cl 3CH3C61-14 2,4 Cl2 5-[5-chloro-i-(2,4-dichlorophenyl)-1H-CIT C6II pyrazol-4-yI]-2-(3-methylbcnzyl)-2/I-tetrazolc 281 Cl 3CH3C6l-T4 2,5 Cl2 5-[5-chloro-l-(2,5-dichlorophcnyfl-lH-CH2 C61-11 pyrazoI-4-yij-2-(-methy1benzy1)-2H-tetrazo1e 282 Cl 3CH3C6H4 2,6 Cl2 5-[5-chloro-l-(,6-dichlorophenyl)-lJJ-CI 12 C5H3 pyrazol-4-yl]-2-(3 -mcthylbenzyl)-2H-tetrazole 283 Cl 3CH3C6U4 3,4 Cl2 5-[5-chloro-l -(3,4-dichlorophenyl)-111-CH2 C5H3 pyrazol-4-yl]-2-(3 -methylbenzyl)-2H-tetrazole 284 Cl 3CH3C6H4 3,5 Cl2 5-[5-chloro-l-(3,5-dichlorophenyl)-IH-CH2 C61-13 pyrazol -4-yl j-2-(3 -methylbenzyl)-2H-tetrazole 285 Cl 3CH3C6H4 2 Br C6H4 5-[l-(2-brornophenyl)-5-chloro-i /J-pyrazol-4-CIT2 yl] -2-(3-methylbenzyl)-211-tctrazolc 286 Cl 3CH3C6H4 3 Br C6H4 5-[l-(3-brornophenyl)-5-chloro-1H-pyrazol-4-CH2 yl] -2--(3-rnethylbenzyl)-2H-tetrazole 287 Cl 3CH3C6H4 4 Br C6H4 5-[l-(4-brornophcnyl)-5-chloro-1H-pyrazol-4-CM2 yl] -2-(3-methylbenzyl)-2H-tetrazole 288 CI 3CR3C6H4 4 F C6H4 5-[5-chioro-i-(4-fluorophenyl)-1H-pyrazol-4-CM2 yl]-2-(3-methyibenzyl)-2H-tetrazole 289 CI 3CT-13C6H4 2 F C6H4 5-[5-chioro-l-(2-fluorophenyl)-1H--pyrazol-4-Cu2 yl]-2-(3-methylhenzyl)-21/-tctrazoic 290 Cl 3Ci13C6H4 2,3(CH3)2 5-[5-ehloro-l-(2,3-dinicthylphcnyl)-lfI-Cu2 C6113 pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole 291 Cl 3C1-l3C6H4 2,4(CH3)2 5-[5-chloro-l-(2,4-dimethylphenyl)-IH-CM2 C6H3 pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole 292 Cl 3CH3C61t4 2,5(CH3)2 5-[5-chloro-I -(2,5-dirnethylphenyl)-IH-Cr12 C6113 pyrazol-4-yl]-2-(3-rnethyl bcnzyl)-21I-tctrazol c 293 Cl 3CFJ3C6H4 2,6(Cl-i3)2 5-[5-chloro-l-(2,6-dirnethylphenyl)-lH-CM2 C6M3 pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole 294 Cl 3C113C6I14 3,4(CFT3)2 5-[5-chloro-l-(3,4-dimcthylphcnyl)-1H-CH2 C6H3 pyrazoi-4-yl]-2-(3 -methylbenzyl)-2H-tetrazole 295 Cl 3CH3C6H1 3,5(CH3)2 5-J5-chloro-l-(3,5-dirnethylphenyl)-IH-CM2 C61-13 pyrazol-4-y1]-2-(3-rncthylbenzy1)2H-tetrazole 296 Cl 3CH3C6H4 2CH2CI-13 5-[5-chloro-1-(2-ethylphenyl)-1H-pyrazol-4-CR2 C6H4 yl]-2-(3 -rnethylbenzyl)-2H-tetrazo!e 297 Cl 3C1-13C6114 4 CII2C113 5-[5-chloro-l-(4-ethylphenyl)-1 iJ-pyrazo[-4-Cf-I2 C6H4 yl]-2-(3 -methylbenzyl)-2H-tetrazole 298 Cl 3 CF13C6H4 4 5-[5-chioro-1 -(4-methoxyphenyl)-IH-pyrazol-CH2 OCH3C5I-14 4-ylj-2-(-rnethylbenzyl)-2H-tetrazole 299 Cl 3CH3C6H4 2 CH3C6H4 5-[5-ehloro-1-(2-methylplienyl)-luJ-pyrazol-4-CR2 yl]-2-(3-incthylbenzyl)-2H-tetrazole 300 Cl 3 CH3C6H4 4CH3C6H4 5-[5-chioro-1 -(4-methylphenyl)-1H-pyrazol-4-CR2 yIj-2-(3 -methylbenzyl)-2H-tetrazole 301 Cl 4N02C6H4 CR3 5-(5-chloro-1 -methyl-IH-pyrazol-4-yl)-2-(4-CR2 nhrobenzyl)-2H-teftazole 302 Cl 4N02C6H4 CH2CH3 5-(5-chloro-l-ethyl-IH-pyrazol-4-yl)-2-(4-CR2 nitrobenzyl)-2H-tetrazole 303 Cl 4N02C51-14 (CH3)2CR 5-[5-chloro-1-(2-rnethylpropyl)-1 iT-pyrazol-4-CT-I2 Cf 12 yll-2-(4-nitrobenzvl)-2H-tetrazole 304 Cl 4N02C51-L CR7Ph 5-( 1 -benzyl-5 -chioro-1 H-pyrazol-4-yl)-2-(4-CH2 nitrobenzyl)-2H-tetrazole 305 Cl 4N02C6H4 C1H5 5-(5-chloro-l -phenyl-I H-pyrazol-4-yl)-2-(4-CIT2 nitrobenzyl)-2H-tetrazole 306 Cl 4N02C6H4 2 CIC6H4 5-[5-chloro-l-(2-chlorophenyl)-1H-pyrazol-4-CR2 yl]-2-(4-nitrobenzyl)-2H-tetrazole 307 Cl 4N02C6H4 3 Cl C5H4 5-[5-chloro-I-(3-chlorophenyl)-l//-pyrazol-4-Cu2 yl] -2-(4-nitrobenzyl)-2H-tetrazole 308 Cl 4N02C6114 4 Cl C6114 5-[5-chloro-1-(4-chlorophenyl)-1H-pyrazol-4-Cl-I2 yl] -2-(4-nitrobenzyl)-2H-tetrazole 309 Cl 4N02C6R4 E 2,3 Cl2 5-[5-chloro-1-(2,3-dichlorophenyl)-lH-Cl-I2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 310 Cl 4N02C61-14 2,4 Cl2 5-[5-chloro-1 -(2,4-dichlorophenyl)-1H-C112 C6113 pyrazol-4-yl]-2-(4-nitrohenzyl)-2ff-tetrazole 311 Cl 4N02C6114 2,5 Cl2 5-[5-chloro-1 -(2,5-dichlorophenyl)-lH-CH2 C61-13 pyrazol-4-ylj-2-(4-nitrohenzyl)-2ff-tetrazole 312 Cl 4NO2C61-14 2,6 Cl2 5-[5-chloro-I -(2,6-dichlorophcnyl)-111-Cl-I2 C6R3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 3 3 Cl 4N02C6H4 3,4 Cl2 5-[5-chioro-I-(3,4-dichlorophenyl)-1H-CIT2 C6IT3 pyrazol-4-yl]-2-(4-nitrohcnzyl)-2J1-tctrazole 314 Cl 4N02C6114 3,5 Cl2 5-[5-chloro-l -@ ,5-dichlorophcnyl)-1 H-CR2 C6H3 pyrazol-4-vll-2-(4-nitrobenzyl)-2H-tetrazole 315 Cl 4NO2C6I 2 Br C6114 5-[1-(2-bromophenyl)-5-chloro-1H-pyrazol-4-CH2 y!]-2-(4-nitrobenzyl)-2H-tetrazole 316 Cl 4N02C6H4 3 Br C6H4 5-[1-(3-bromophenyl)-S-chloro-1H-pyrazol-4-CH2 yl] -2-(4-nitrobenzyl)-2H-tetrazole 317 Cl 4N02C5H4 4 Br C5H4 5-[ I -(4-bromophcnyl)-5-chloro-Il-p yrazol-4-CH2 yl] -2-(4-nitrohcnzyl)-2H-tetrazole 318 Cl 4N02C61-L 4 F C6H4 5-[5-chloro-1-(4-fluorophenyl)-1H-pyrazol-4-CIT2 yl]-2-(4-nitrobenzyl)-2H-tetrazole 319 CI 4N02C6H4 2 F C6H4 5-[5-eh1oro-l-(-fluorophenyl)-lll-pyrazo1-4-CM2 yI]-2-(4-nitrohenzyl)-2H-tetrazole 320 Cl 4N02C6H4 2,3(CH3)2 5-[5-ehloro-1-(2,3-dimethylphenyl)-IH-CM2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 321 Cl 4N02C6H4 2,4(CI-13)2 5 -[5-ebloro-1 -(2,4-dimethyiphenyl)-IH-CU2 C6H3 pyrazo]-4-yl]-2-(4-nitrobenzyl)-2H-telrazole 322 Cl 4N02C6R4 2,5(CH3)2 5 -[5-chioro-1 -(2,5 -dimethyiphenyl)-1 H-Cl-I2 C61-13 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 323 Cl 4N02C6H4 2,6(CH3)2 5-[5-chloro-1 -(2,6-dirnethyiphenyl)-1H-CIT2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 324 CI 4N02C6H4 3,4(CH3)2 5-[5-chloro-I -(3,4-dimethyiphenyl)-111-CM2 CM3 pyrazol-4-yI]-2-(4-nitrobcnzyl)-211-tetrazole 325 Cl 4N02C6H4 3,5(C1-13)2 5-[5-chloro-1 -(3,5-dimethyiphenyl)-111-CH2 C6H3 pvrazol-4-ylj-2-(4-nitrobcnzyl)-2H-tetrazole 326 CI 4NOzC5H, 2CH2CH3 5-[5-chloro-I -(2-ethy[phenyl)-T H-pyrazol-4-CR2 C6H4 yl]-2-(4-nitrobenzyl)-211-tetrazolc 327 Cl 4N02C5H4 4CH2CH3 5-[5-ehloro-1 -(4-ethyiphenyl)-1 H-pyrazol-4-Cl-I2 C6114 yl]-2-(4-nitrobenzyl)-2H-tetrazole 328 Cl 4N02C6H4 4 5-[5-chloro-1 -(4-methoxyphenyl)-1 H-pyrazol-CR2 OCR3C6H4 4-yl] -2-(4-nitrobenzyl)-2H-tetrazole 329 Cl 4N02C5H4 2 CH3C6H4 5-[5-chloro-1 -(2-methylphenyl)-I H-pvrazol-4-CH2 yl] -2-(4-nitrohenzyl)-2H-tetrazole 330 Cl 4N02C61J4 4 CI-I3C6H 5-[5 -chioro-1 -(4-methyiphenyl)-1H-pyrazol-4-CM2 yl] -2-(4-nitrobenzyl)-2H-tetrazole Example 6: 5-(5-bromo-1-methvl-1 H-pyrazol-4-yI)-2-methyl-2H-tetrazole (Compound 331): Dissolve 5-(5-hromo-1 -methyl-1H-pyrazol-4-yl)-2H-tetrazole (9.5 grn, 0.0414 moles) S obtained from Example 3 or 4, in acetonitrile (100 nil). Potassium hydroxide (5.71 gm, 0.10 moles) and methyl iodide (24.5 gm, 0,171 moles) were added and stirred at 20-30°C for 20-hour. The progress of the reaction was monitored by HPLC. The aeetonitrile was recovered at 55-60°C at reduced pressure. To the above residue dichloroniethane (100 ml) and DI water (1 00 ml) was added and stirred the above reaction mixture for 10-15 mm at 20- 25°C. The reaction mixture was allowed to settle, The organic layer was separated and aqueous layer was extracted with DCM. The entire organic layer was transferred to the reaction vessel and washed with 10% brine solution (50 nil). StilTed for 10-15 mm and separated the final aqueous layer and organic layer. The organic layer was evaporated to obtain the crude product, 5-( -chloro-1-niethyl-1H-pyrazole-4-yl)-2-methyl-2H-tetrazole), or 5-(5-chloro-l-methyl-IH-pyrazole-4-yl)-l -methyl-2H-tctrazolc), mixture thereof The desired regio-isomer, 5-(5-chloro-I-methyl-I Jf-pyrazol-4-yl)-2-methyl-2H-tetrazole), was isolated by column chromatography.
Drywt 5gm Yield: 0.53 w/w(50%) IIPLC purity 99.95% Compounds 332-600 were prepared by following the experimental procedure of Example 6 using appropriate intermediates.
Compo-R2 IUPAC Name undNo. ____ ___________ ______________________________ 332 Br CH3 CH2CIT3 5-(5-bromo-l-ethyl-IH-pyrazol-4-yI)-2- __________ _____ _____ _____________ mcthyl-2H-tetrazole 333 Br CIT3 (CH3)2CH 5-[5-bromo-l-(2-rnethylpropyl)-lIf-pyrazol-4- __________ _____ ____________ CH2 yl] -2-methyl-211-tetrazolc 334 Br CH3 Cf-J2Ph 5-(1 -benzyl-5-bromo-1H-pyrazol-4-yl)-2- __________ _____ ____________ _____________ methyl-2H-tetrazole 335 Br CH3 C61-15 5-(5-bromo-1-phenyl-1H-pyrazol-4-yl)-2- __________ _____ ____________ _____ methyl-2H-tctrazolc 336 Br CH3 2 C1C6I 14 5 -[5-bromo-1 -(2-chlorophenyl)-1 I-1-pyrazol-4- __________ _____ ____________ _____________ yl] -2-meihyl-211-tetrazole _____________________ 337 Br Cl-I3 3 Cl C61-L 5-[5 -bromo-1 -(3 -chiorophenyl)-1H-pyrazol-4- _________ ____ ___________ ____________ yl] -2-methyl-2H-tetrazole 338 Br CH3 4 C1C6I-L4 5-[5-bromo-l-(4-ehlorophcnyl)-IJJ-pyrazol-4- __________ _____ ____________ -_________ yl]-2-methyl-2H-tetrazole 339 Br Cl-I3 2,3 Cl2 5-[5-bromo-l-(2.3-dichlorophenyl)-1H- __________ _____ ____________ C6H3 pyrazol-4-yl]-2-mcthyl -2J1-tctrazolc 340 Br Cit3 2,4 Cl2 5-[5-bromo-l-(2.4-dichlorophenyl)-lII- _________ _____ ___________ C6H3 pyrazol-4-ylj-2-methyl-211-tetrazole 341 Br CH3 2,5 Cl2 5-[5-bromo-1-(2,5-dichlorophenyl)-1H- __________ _____ ____________ C6H3 pyrazol-4-ylj -2-methyl-2H-tetrazole 342 Br CH3 2.6 Cl7 5-[5-bromo-l-(2,6-dichlorophenyl)-1H- __________ _____ ____________ C5T-I3 pyrazol-4-yl]-2-methyl-2H-tetrazole 343 Br CH3 3,4 Cl2 5-[5-bromo-1-(3,4-dichlorophcnyl)-1H- _____ _____ ____________ C6H3 pyrazol-4-yIj-2-methyl-2H-tetrazole 344 Br Cl-I3 3,5 Cl2 5-[5-bromo-l -(3,5-dichlorophenyl)-111- _________ _____ ___________ C5H ______ pyrazol-4-yl]-2-rnethyl-2J1-tetrazole 345 Br CM3 2 Br C5H4 5-[5-brorno-1-(2-bromophenyl)-1H-pyrazol-4- __________ ______ ____________ _____________ yll -2-methyl-2H-tetrazole 346 Br CH3 3 Br C5H4 5-[5-bromo-1 -(3-bromophenyl)-1H-pyrazol-4- _________ _____ ___________ ____________ yll -2-methyl-2H-tetrazole 347 Br CH3 4 Br C51-14 5-[5-brorno-1-(4-bromophcnyl)-1II-pyrazol-4- _________ _____ ___________ ____________ yfi -2-methyl-2H-tetrazole 348 Br CU3 4 F C61-14 5-[5-bromo-1-(4-fluorophenyl)-1H-pyTazol-4- ___________ ______ _____________ y]j-2-methyl-211-tetrazole 349 Br CM3 2 F C6i14 5-[5-brorno-1-(2-fluorophenyl)-IH-pyrazol-4- __________ _____ ____ yl]-2-rnethyl-2H-tetrazole ________________ 350 Br CU3 2,3 (CM3)2 5-[5-brorno-1 -(2,3 -dimethylphenyl)-IH- __________ ______ ____________ C6H3 pyrazol -4-y1]-2-methy-2/I-tetrazo]e 351 Br CM3 2,4 (CM3)2 5-[5-bromo-1-(2,4-dimethylphenyl)-1H- __________ ______ ____________ C61 13 pyrazol-4-yll-2-methyl-2H-tetrazole 352 Br CM3 2,5(CH3)2 5-[S -brorno-1 -(2.5 -dimethyiphenyl)-111- _________ _____ ___________ C6H3 pyrazol-4-yl]-2-methyl-2H-tetrazole 353 Br CU3 2,6(CH3)2 5-[5-bromo-i-(2,6-dimethylphenyl)-1 H- ______ ____ C6H3 ______ pyrazol-4-yl]-2-rnethyl-2H-tetrazole 354 Br Cu3 3,4(C113)2 5-[5-bromo-1 -(3,4-dirnethyiphenyl)-1H- _________ _____ ___________ C6H3 pvrazol-4-vl]-2-methyl-2H-tetrazole 355 Br CH3 3,5(CH3)2 5-[5-brorno-1-(3,5-dimethylphenyl)-1fJ- __________ ______ ____________ C6M3 pvrazol-4-vfl-2-methyl-2H-tetrazole 356 Br CH3 2CU2CM3 5-[5-brorno-1 -(2-ethylphenyl)-1 JJ-pyrazol-4- _______ ___----------coN4 vl]-2-methyl-2H-tetrazole 357 Br CI 13 4C1 12C1 13 5 -[5 -bromo-1 -(4-ethyiphenyl)-1H-pyrazol-4- __________ ______ ____________ C(,T-14 yl] -2-rncthyl-211-tetrazolc 358 Br CU3 4 5-[5-bronio-I -(4-methoxyphenyl)-I H-pyrazol- ______ OCH3C5H4 4-yI]-2-methyl-2H-tetrazole 359 Br CIT3 2C1 13C61-14 S -[5-bromo-I -(2-methyiphenyl)-1H-pyrazol-4- __________ ______ ____________ _____________ yl] -2-methyl-2H-tetrazole 360 Br CU3 4CH3C6U4 5-[5-brorno-I -(4-methyiphenyl)-I /J-pyrazol-4- _________ _____ ___________ ____________ yl] -2-methyl-2H-tetrazole 361 Br CH2CI-13 CU3 5-(5-brorno-1-methyl-1H-pyrazol-4-yl)-2- __________ _____ ____________ ___________ ethyl-2J1-tetrazole 362 Br CH2CI-13 CT-12C1-13 5-(5-brorno-1 -cthyl-1H-pyrazol-4-yl)-2-ethyl- _________ _____ ___________ ____________ 2H-tetrazole 363 Br CI-12CH3 (CH3)2CH 5-[5-bromo-I -(2-niethylpropy-1 H-pyrazol-4- __________ _____ ____________ CU2 yl]-2-cthyl-211-tetrazolc 364 Br CH2CU3 CU2Ph 5-(1-benzyl-5-brorno-IH-pyrazol-4-yl)-2- _____ _______ _____________ ethyl-2H-tetrazole 365 Br CI 12C1 13 C6115 5-(5-brorno-1 -phenyl-TH-pyrazol-4-yl)-2- ________ _____ ____________ _____________ ethyl-211-tctrazol e 366 Br CM2CU3 2 C1C6H4 5-[5-bromo-1-(2-chlorophenyl)-1H-pyrazol-4- ____________ _____________ yl]-2-ethyl -211-tetrazolc 367 Br CI-12CH3 3 Cl C6M4 5-[5-bromo-1-(3-chlorophenyl)-1H-pyrazol-4- ______ __________ ____________ yl]-2-ethyl-2H-tetrazole 368 Br C112C113 4 Cl C6114 5-[5-bronio-1-(4-chlorophenyl)-IH-pyrazol-4- __________ _____ ____________ _____________ yl]-2-ethyl-2H-tetrazole 369 Br CI-12CH3 2,3 Cl2 5-[5-brorno-1 -(2,3-dichlorophenyl)-1 H- __________ _____ ____________ C6M3 pyrazol-4-ylj-2-cthyl-2H-tetrazole 370 Br CI-12CH3 2,4 Cl2 5-[5-brorno-1-(2,4-dichlorophenyl)-IH- _______ ____________ C6H3 pyrazol-4-yUj-2-ethyl-2H-tetrazole 371 Br CI-12CH3 2,5 Cl2 5-[5-brorno-I -(2,5-dichiorophenyl)-I H- ______ ____________ C61 13 pyrazol-4-yl]-2-ethyl-2H-tetrazolc 372 Br CH2CH3 2,6 Cl2 5-[5-hromo-I-(2,6-dichloropheny-1H- __________ ______ ____________ C6113 pyrazol-4-yl]-2-ethyl-2f1-tctrazolc 373 Br CFT2CH3 3.4 Cl2 5-[5-bromo-1-(3,4-dichlorophenyl)-IH- __________ ______ ____________ C6H3 pyrazol-4-ylj-2-ethyl--2H-tetrazole 374 Br CH2CH3 3,5 Cl2 5-[5-bromo-1-(3,5-dichlorophenyl)-IH- _________ _____ __________ C6H3 pyraiol-4-yl]-2-ethyl-2H-tetrazole 375 Br CH2CH3 2 Br C6114 5-[5-brorno-1 -(2-bromophcnyl)-1 H-pyrazol-4- _________ _____ ____ ____________ ylj-2-ethyl-2H-teirazole 376 Br C112C113 3 Br C5H4 5-[5-bromo-1-(3-brornophenyl)-1JJ-pyrazol-4- __________ ______ _____________ ______________ yl]-2-ethyl-2H-tetrazolc 377 Br CH2CH3 4 Br C51-14 5-[5-bromo-1 -(4-bromophenyl)-IH-pvrazol-4- __________ ______ ____________ _____________ yl]-2-cthyl-2H-tetrazole 378 Br CH2CH3 4 F C61-J4 5-[5-bromo-1-(4-fluorophenyl)-IH-pyrazol-4- _______ ____ _________ _________ 11111:2H4etrazo1e 379 Br C1-12CH3 2 F C61-L 5-[5-bromo-1-(2-fluorophenyl)-1II-pyrazol-4- ___________ _____ _____ ______________ yl] -2-c thyl-2 H-tetrazole 380 Br C112C113 2,3(CH3)2 5-[5-hromo-1 -( ,3-dimethvlphenyl)-1H- -_________ ______ ____________ C6i13 pyrazol-4-yl]-2-ethyl-21/-tetrazolc 381 Br CH2CI-13 2,4(CH3)2 5-[5-brorno-1 -(2,4-dimelhylphenyl)-1H- __________ ______ ____________ C6F13 pyrazol-4-yl]-2-ethyl-2/1-tetrazole 382 Br CR2CH3 2,5(CH3)2 5-[5-bromo-1 -(2,5-dirnethylphenyl)-IH- _________ _____ ___________ C6H3 pyrazol-4-yl]-2-cthyl-2H-tetrazole 383 Br C1-12CH3 2.6(CH3)2 5-[5-bromo-1 -(2,6-dimethylphenyl)-IH- __________ ______ ____________ C6H3 pyrazol-4-yfl-2-cthyl-2H-tetrazole 384 Br C112C113 3.4(C1 13)2 5-[5-bromo-I -(3,4-dimcthyphcny1)-lilT- _____ ___________ C6H3 pvrazol-4-yl]-2-ethyl-2H-tetrazole 385 Br CH2CT-13 3,5(CI-!3)2 5-[5-brorno-1 -(3,5-dimethylphenyl)-IH- _________ _____ ___________ C6113 pyrazol-4-yI]-2-ethyl-2/I-tctrazole 386 Br CH2CH3 2C1-12C1-13 5-[5-bromo-1-(2-ethylphenyl)-1H-pyrazol-4- _________ _____ __________ C6H4 yl]-2-cthyl-2H-tetrazole 387 Br CH2CH3 4C112C113 5-[5-bromo-1 -(4-ethylphenyl)-I f[-pyrazol-4- ___________ ______ _____________ C6114 y1-2-ethy1-2H-tetrazo1c 388 Br CH2CH3 4 5 -[5-brorno-I -(4-methoxyphenyl)-1H-pyra.zol- __________ ______ ____________ OCH3C6H4 4-y1-2-cthyl-2II-tctrazoIe __________ 389 Br CH2CH3 2 CH3C6H4 5-[5-brorno-1 -(2-methyiphenyl)-1H-pyrazol-4- __________ ______ ____________ _____________ yIj-2-ethyl-2H-telrazole ____________________ 390 Br CH2CH3 4 CH3C6H4 5-[5-bromo-1-(4-methylphenyl)-1H-pyrazol-4- _________ _____ ___________ ____________ yII-2-ethyl-2TT-tctrazolc 391 Br CH(CH3)2 CH3 5 -(5-brorno-1-methyl-1H-pyrazol-4-yl)-2-( 1- __________ ______ ____________ _____________ rnethylcthyl)-211-tetrazole _______________ 392 Br CH(CH3)2 CH2CH3 5-(5-bromo-1-ethyl-1H-pyrazol-4-yl)-2-(1- __________ ______ ____________ _____________ methylethyl)-2H-tetrazole 393 Br CH(CH3)2 (CH3)2CH 5-[5-bromo-1 -(2-mcthylpropyl)-1 if-pyrazol-4- __________ ______ ____________ CH2 yl]-2-(1 -rnethylethyl)-211-tetrazolc 394 Br CH(CH3)2 CH2Ph 5-(1 -henzyI-5-bronio-1H-pyrazo1-4-y-2-(1- __________ ______ ____________ _____________ mcthylcthyl)-2H-tetrazole ___________________ 395 Br CH(CH3)7 C61-15 5-(5-bromo-1-phenyl-1 JJ-pyrazol-4-y])-2-(1- __________ _____ ____________ _____ methylethyl)-2H-tetrazole 396 Br CH(CH3)7 2 C1C6114 5-[5-bromo-I -(2-chiorophenyl)-I ii-pyrazo]-4- _________ _____ ___________ yl]-2-(l -rnethylethyl)-2H-tetrazole 397 Br CH(CH3)7 3 Cl C6114 5-[5-hromo-l-(3-chlorophcnvl)-1 ff-pyrazol-4 _________ _____ ________ ____________ yl]-2-(l-rnethylethyl)-2H-tetrazole 398 Br CI-I(CH3)2 4 CI C6H4 5-[5-hromo-l-(4-chlorophenyl)-IH-pyrazol-4- _________ _____ __________ ___________ yI]-2-(1 -rnethylethyl)-2H-tctrazole 399 Br CH(CN3)2 2,3 Cl2 5-[S-bromo-1 -(2,3-dichlorophcnyl)-1II- __________ _____ ____________ C6H3 pyrazoi-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole 400 Br CH(CH3)2 2,4 Cl2 5-[5-bromo-l-(2.4-dichlorophenyl)-1H- _________ _____ ___________ C6H3 pyrazol-4-yI]-2-(I -rnethylethyl)-2H-tetrazole 401 Br CH(CI-13)2 2,5 Cl2 5-[5-bromo-1-(2,5-dichlorophenyl)-IJT- __________ _____ __________ C6H3 pyrazol-4-yfl-2-( 1 -methylethyl)-2H-tetrazole 402 Br CiI(C113)2 2,6 Cl2 5-[5-bromo-1-(2,6-dichlorophenyl)-1H- _________ _____ ____________ C6113 pyrazol-4-yIJ-2-(I -mcthylethyl)-211-tetrazole 403 Br CH(CH3)2 3,4 Cl2 5-[5-brorno-1-(3,4-diclilorophenyl)-1H- __________ _____ ____________ C6H3 pyrazol-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole 404 Br CH( H3)2 3,5 Cl2 5-[5-bromo-l-(3,5-dichloropheny-1iJ- ____ ____ ____________ C61-f3 pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazolc 405 Br CH(CH3)2 2 Br C6H4 5-[5-hromo-I-(2-brornophenyl)-1H-pvrazol-4- __________ _____ ____________ _____________ yll-2-( 1 -mcthylethyl)-2H-tetrazole ____________ 406 Br CH(CH3)2 3 Br C6H4 5-[5-bromo-I -(3-bromophenyl)-1H-pyrazol-4- __________ _____ ____________ _____________ yll-2-( 1 -rnethylethyl)-2H-tetrazole 407 Br CT-T(CH3)2 4 Br C61-14 5 -L5-brorno-1 -(4-brornophenyl)-1 H-pyrazol-4- _________ _____ ___________ ____________ yl]-2-(l-rnethylethyl)-2H-tetrazole __________ 408 Br CH(CH3)2 4 F C6H4 S -[5-brorno-I -(4-fluorophenyl)-I JI-pyrazol -4- ___________ ______ _____________ _____________ ylj-2-(l -rnethylethyl)-2H-tetrazole 409 Br CH(CH3)2 2 F C6114 5-[S-bromo-l-(2-fluorophenyl)-I/I-pyrazol-4- __________ _____ __________ ____________ ylI-2-( 1 -methylethyl)-2H-tetrazole 410 Br CII(C113)7 2,3(C1-13)7 5-[5-hromo-I -(2,3-diniethylphenyl)-1H- ___________ ______ _____________ C6H3 pyrazol-4-yfl-2-( I -methylethyl)-211-tetrazole 411 Br CH(CH3)2 2,4(CH3)2 5-[5-brorno-l-(2,4-dirnethylphenyl)-1H- __________ _____ ___________ C6H3 pyrazol-4-yi]-2-( 1 -rnethylethyl)-2H-tetrazole 412 Br CII(C113)2 2,5(CFI3)2 5-[5-bromo-1 -(2,5-dimethyiphenyl)-IH- __________ _____ ____________ C6113 pyrazol-4-yl]-2-(l -mcthylethyl)-2H-tetrazole 413 Br CT-I(CH3)2 2,6(CH3)2 5-[5-bromo-I-(2.6-dimethylphenyl)-1H- __________ _____ ____________ C61-I3 pyrazol-4-ylj-2-(l -methylethyl)-2H-tetrazole 414 Br CH(CH3)2 3,4(C1-1)2 5-[5-brorno-1 -(3.4-dimethylphenyl)-1 H- _________ _____ ___________ C6H3 pyrazol-4-yl]2(1 -rnethylethyl)-2H-tetrazole 415 Br CH(CH3)2 3,5(CH3)2 5-[5-bromo-1-(3.5-dimethylphenyl)-TI!- __________ _____ ____________ C5H3 pyrazol-4-ylj-2-( -methylethyl)-2H-tetrazole 416 Br CH(CH3)2 2CH2CLI3 5-[5-bromo-1 -(2-ethyiphenyl)-1II-pyrazol-4- __________ _____ ____________ C61-L4 ______ yI]-2-(1 -methylethyl)-2H-tetrazole 417 Br CH(Ci-13)2 4CILCI13 5-[5-bromo-1-(4-cthylphenyl)-l H-pyrazol-4- _________ _____ ____ C6H4 yl]-2-(1-methylethyl)-2H-tetrazolc 418 Br CII(C113)2 4 S-[5-brorno-1 -(4-methoxyphenyl)-lH-pyrazol- _________ _____ ___________ 0C113C6114 4-yll-2-(1-methylethyl)-2H-tetrazole 419 Br CT-I(CH3)2 2CH3C6H4 5-[5-bromo-1 -(2-methyiphenyl)-1 H-pyrazol-4- __________ _____ ____________ _____________ yI]-2-(I -methylethyl)-2f[-tetrazole 420 Br CH(CH3)2 4C113C4L4 5-[5-bromo-1-(4-rnethylphenyl)-1 II-pyrazol-4- __________ ______ ____________ _____ yl] -2-( 1 -methylethyl)-2H-tetrazole 421 Br CH2C6F15 CIT3 2-benzyl-5-(5-bromo-i-methyl-111-pyrazol-4- ________ ______ _________________________ yl)-2H-tetrazole 422 Br CH2C6H5 CH2CH3 2-benzyI-5-(5-brorno-1-ethy-1H-pyrazo1-4- __________ ______ _________________________ yl)-211-tetrazole 423 Br CH2C6H5 (CH3)2CH 2-benzvl-545-bromo-1-(2-methvlpropyl)-IH- _________ _____ CH2 pyrazol-4-yl]-2[f-tetrazole 424 Br CU2C6H5 CI-T2Ph 2-benzyl-5-(l-henzyl-5-hromo-1 J[-prazol-4- ___________ ______ _____________ _____________ yl)-2H-tetrazole 425 Br CH2C6I-15 C61 15 2-benzyl-5-(5 -brorno-1 -phenyl-1 H-pyrazol-4- __________ ______ ____________ _____________ yl)-2H-tetrazole 426 Br CH2C6H5 2 C1C6114 2-benzyl-5-[5-bromo-1-(2-chlorophcryl)-1/J- __________ ______ _________________________ pyrazol-4-yl]-2H-tetrazole 427 Br CH2C6H5 3 Cl C6H.4 2-benzyl-5-[5-bromo-1-(3-chlorophenyl)-1H- __________ ______ _________________________ pyrazol-4-yI]-211-tetrazole 428 Br CH2C5H5 4 Cl C6114 2-benzyl-5-[5-bromo-1-(4-chlorophcnyl)-1II- _________ _____ ___________ _____ ____ pyrazol-4-ylj-2H-tetrazole 429 Br C1-12C6H5 2,3 Cl2 2-benzyl-5-[5-brorno-1-(2,3-dichlorophenyl)- ____________ C6H3 IH-pyrazol-4-yfl -2H-tetrazole Rio Br CI-12C6H5 2,4 Cl2 2-benzyl-5-.[5 -brorno-1 -(2,4-dichiorophenyl)- __________ ______ ____________ C6113 I JI-pyrazol-4-yl] -2Jf-tctrazole 431 Br CI-1,C6H5 2,5 Cl2 2-benzyl-5-[5-bromo-l -(2,5-dichiorophenyl)- _________ _____ ___________ CH3 I IJ-pyrazol-4-ylj-21i1-tetrazole _____ 432 Br CH2C6H5 2,6 Cl2 2-benzyl-5-[5-bromo-1-(2,6-dichlorophenyl)- __________ ______ _________________________ 1 H-pyrazol-4-yl]-211-tetrazole 433 Br CH2C6H5 3,4 Cl2 2-benzyl-5-[5-bromo-1-(3,4-dichlorophenyl)- _________ _____ C6H3 1H-pyrazol-4-yl] -2H-letra2ole 434 Br C112C6H5 3,5 Cl2 2-benzyl-5-[5-bromo-1 -(3,5-dichioroplienyl)- _______ ______ ____________ C6f 13 1 H-pyrazol -4-yl] -2H-tetrazolc 435 Br CH2C6H5 2 Br CH4 2-henzyl-5-[5-hrorno-1 -(2-brornophenyl)-IH- _________ _____ ___________ ____________ pyrazol-4-yl]-211-tetrazole _______________ 436 Br CH2C6H5 3 Br C6H4 2-benzvl-5-[5-brorno-l-(3-bromophenyl)-1 II- _________ _____ ___________ ____________ pyrazol-4-yl]-2H-tetrazole 437 Br C112C6F15 4 Br C6T-14 2-benzyl-5-[5-bromo-l-(4-bromophenyl)-1H- _________ _____ ___________ ____________ pyrazol-4-yl]-2H-tetrazole 432 Br C1-12C61-]5 4 F C5H4 2-benzyl-545-brorno-1-(4-Iluorophenyl)-1H- _______________ ________________________ pyrazol-4-yl]-2H-tctrazolc 439 13r CH2C6H5 2 F C6H4 2-benzyl-5-[5-bromo-l-(2-fiuorophenyl)-1H- _________________ ___________________ pyrazol -4-yl]-211-tetrazole 440 Br CT-T2C6H5 2,3(CTT3)2 2-benzyl-5-[5-bromo-l-(2,3-dichlorophenyl)- _________________ C6H3 I H-pyrazol-4-yIJ-21f-letrazole 441 Br CI-12C6H5 i 2,4(CH3)2 2-benzyl-5-[5-bromo-l-(2.4-dichlorophenyl)- _________ _____ ___________ C6H3 I H-pyrazol -4-ylj-2H-tetrazole 442 Br CH2C6I-T5 2,5(C113)2 2-benzyl-5-[5-hromo-I -(2,5-dichlorophenyl)- ______ _____ C6H3 I H-pyrazol-4-yl] -2H-tetrazole 443 Br C112C6115 2,6(CH3)2 2-benzyl-5-[5-brorno-l-(2.6-dichlorophenyl)- __________ ______ ____________ C6H3 1H-pyrazol-4-yl] -2H-tetrazole 444 Br CH2C6HS 3,4(CH3)2 2-benzyl-5-[5-brorno-l -(3,4-dichiorophenyl)- __________ ______ ____________ CJ-13 I H-pyrazol-4-yl]-211-tetrazole 445 --Br C112C6F15 3,5(CH5)2 2-benzyl-5-[5-bromo-1-(3,5-dich1oropheny- __________ ______ ____________ C6F13 1 H-pyraz& -4-yl]-2J/-tetrazole 446 Br CH2C6H5 2CHCH3 2-benzyi-5-[5-bromo-1-(2-ethylphenyl)-I H- __________ ______ ____________ C6H4 pyraz&-4-yl]-2H-tetrazole 447 Br CH2CÔH5 4CH2CH3 2-benzyl-5-[5 -brorno-1 -(4-ethyiphenyl)-I H- __________ ______ ____________ C61 14 pyrazol-4-yij-2H-telrazok 448 Br CH2C6H5 4 2-benzyl-5-[5-brorno-1 -(4-methoxyphenyl)- _____ __________ OCH3CJ-T4 1 fJ-pyrazol-4-yl]-2H-tetrazole 449 Br CH2C6H5 2CH3C6H4 2-benzyl-5-[5-brorno-1-(2-methylphenyi)-1 H- __________ _____ ________ _____________ pyrazoi-4-ylJ-2H-tetrazole 450 Br C112C6115 4C113C51-14 2-benzy-5-[5-hrorno-1 -(4-methylphenyl)-1 H- _________ ___________ ____________ pyrazo l-4-yI]-2H-tetrazole 451 Br 4BrC6I 14 C114 2-(4-bromobenzyi)-5-(5-bromo-1-methyl-i 11- _________ _____ CH2 ____________ pyrazol-4-yl)-2H-tetrazole ______ 452 Br 4BrC6H4 CH2CI-T3 2-(4-bromobenzyl)-5-(5-brorno-1-ethyl-1H-CH2 ____________ pyrazol-4-yl)-2H-teftazoie 453 Br 4BrC6I-14 (CH3)2CH 2-(4-hrornobenzyl)-5-[5-bromo-1-(2- _________ ____ CH2 CH2 mcthylpropyl)-1H-pyrazol-4-yi]-2H-tetrazole 454 Br 4BrC6I 14 CI-I2Ph 5-( -benzyl-5 -bromo-1IJ-pyrazol-4-vl)-2-(4- __________ _____ CH2 _____________ bromo benzyl)-211-tetrazoie 455 Br 4BrC5H4 C5H5 2-(4-hromobenzyl)-5-(5-bromo-1-phenyl-1H- _________ _____ CH2 ____________ pyrazol-4-yl)-2H-tetrazole ________ 456 Br 4BrC6H4 2 C1C5H4 2-(4-brotnohenzyl)-5-[5-bromo-1-(2- ____ _____ CH2 ____________ chiorophenyl)-IH-pyrazoi-4-yl]-2H-tetrazole 457 Br 4BrC6IT4 3 Cl C6114 2-(4-bron-iobenzyl)-5-[5-hromo-l-(3- _________ _____ CIT2 ____________ chlorophenyl)-1If-pyrazol-4-yl]-211-tetrazole 458 Br 4BrC6TI4 4 Ci C6114 2-(4-broniobenzyl)-5-[5-hrorno-1-(4- __________ _____ CIT2 _____________ chlorophenyl)-1 H-pyrazoi-4-yIj-211-tetrazole 459 Br 4BrC5H4 2,3 Cl2 2-(4-bromobenzyl)-5-[5-bromo-l-(2,3- _________ _____ CU2 C5113 dichiorophenyl)-I H-pyrazoi-4-yI]-211-tetrazole 460 Br 4BrC6H4 2,4 Cl2 2-(4-bromobcnzyl)-5-[5-hromo-1-(2,4- _________ _____ CH2 C5H3 dichlorophenyi)-1 H-pyrazol-4-yl] -2H-tetrazoie 461 Br 4BrC6I14 2,5 Cl2 2-(4-bromobenzy1)-5-5-brorno-i-(2,5- _________ _____ CH2 C5H3 dich1oropheny-JJ-pyrazol-4-yl]-2H-tetrazole 462 Br 4BrC6H4 2,6 Cl2 2-(4-hromobenzyl)-5-[5-bromo-1-(2,6- _________ _____ CH2 C1H3 dichlorophenyl)-IH-pyrazoi-4-yi]-2H-tetrazole 463 Br 4BrC6H4 3,4 Cl2 2-(4-bromohenzy1)-5-5 -brorno-1 -(3.4- _________ _____ CH2 C5H3 dichlorophenyl)-1H-pyrazol-4-yi]-2H-telrazole 464 Br 4BrC6H4 3,5 Cl2 2-(4-bromoherizyl)-5-[5-bromo-1-(3,5- __________ ______ CIT2 C5T-T3 dichiorophenyl)-I H-pyrazol-4-yi]-211-tctrazoie 465 Br 4BrC5I-14 2 Br C6F14 2-(4-bromobenzyl)-5-[5-bromo-1-(2- _________ _____ CFI2 _______ brornophenyl)-1 fT-pyrazol-4-y1]-2H-tetrazole 466 Br 4BrC6H4 3 Br C6fl4 2-(4-bromobenzyl)-5-[5-bromo-I-(3- __________ _____ CIT7 _____________ bromophenyl)-1 Ii-pyrazol-4-yI]-211-tetrazole 467 Br 4BrC6H4 4 Br C61-T4 2-(4-bromobenzyl)-5-[5-bromo-I-(4- __________ _____ Cl-T2 ____________ bromophenyl)-l H-pyrazol-4-ylj -2/i-tctrazole 468 Br 4BrC5H4 4 F C5H 2-(4-hromobenzyl)-5-5-brorno-l-(4- __________ _____ CH2 _________ fluorophenyl)-1 H-pyrazol-4-yl] -2H-tetrazole 469 Br 4BrC6H4 2 F C6T14 2-(4-bromobenzyi)-5-[5-bromo-1-(2- __________ _____ CH2 _________ fluorophenyl)-I Ii-pyrazol-4-yl] -211-tctrazole 470 Br 4BrC6H4 2,3 (Cl-I3)2 2-(4-broniobenzy-545-bromo-1-(2,3- CH2 C6H3 dimethyiphenyl)-I H-pyrazol-4-yl]-211- __________ ______ ____________ _____________ tetrazole 471 Br 4BrC6H4 2,4(CH3)2 2-(4-bromobcnzyl)-3-[5-hrnmo-1-(2.4- Cl-I2 C6H3 dimethyiphenyl)-I H-pyrazol-4-ylj-2H- _________ _____ ___________ _________ tetrazole 472 Br 4BrC6H4 2.5(C113)2 2-(4-bromobenzyl)-5-[5-bromo-1 -(2.5- CM2 C6H3 dimethyiphenyl)-1 H-pyrazol-4-yl]-211- __________ ______ ____________ _____________ tetrazole 473 Br 4BrC6H4 2,6(CI-13)2 2-(4-bromobenzyl)-5-[5-bromo-1-(2,6- CM2 C6H3 dimethyiphenyl)-1 H-pyrazol-4-ylJ-211- __________ ______ tetrazole 474 Br 4BrC6H4 3,4(CFI3)2 2-(4-bromobenzyl)-5-[5-bromo-1-(3,4- CH2 CH3 dirnethyiphenyl)-1 H-pyrazol-4-y!J-21-J- ___________ ______ _____________ _____________ tetrazole 475 Br 4BrC6M4 3,5 (CH3)2 2-(4-bromobenzyl)-5-[5-hromo-1-(3,5- Cl-I2 C51-13 dirnethyiphenyl)-1 H-pyrazol-4-yl] -2H- ______ ______ ____________ _____________ tetrazol c 476 Br 4BrC5H4 2CT-12C113 2-(4-bromobenzyl)-5-[5-brorno-1 -(2- _________ _____ CH2 C6H4 ethyiphenyl)-I H-pyrazol-4-yl]-211-tetrazole 477 Br 4BrC5II4 4CH2CH3 2-(4-bromobenzy-5-[5-hrorno-i-(4- _________ _____ CH2 C6H4 ethyiphenyl)-I H-pyrazol-4-yl]-2H-tetrazole 478 Br 4BrC5II4 4 2-(4-bromohenzyl)-5-[5-bromo-l-(4- CM2 OCT 13C61 L4 methoxyphenyl)-I IJ-pyrazol-4-yl]-211-tetrazole 479 Br 4BrC6II4 2C1-13C6H1 2-(4-hromohenzyl)-5-[5-bromo-1-(2- _________ _____ CM2 ____________ methylphenyl)-1 H-pyrazol-4-yl]-2LI-tetrazole 480 Br 4BrC5TI4 4 Cl-13C6H1 2-(4-brornobenzyl)-5-[5-bromo-1-(4- _________ _____ CH2 ____________ methyiphenyl)-I J/-pyrazol ±xI}2H4etraJo1e 481 Br 4CNC6H4 CM3 4-{ [5-(5-brorno-1-methyl-1H-pyrazol-4-yl)- _________ _____ Cl-i2 ___________ 2H-tetrazol-2-yl]methyl}benzonitrile 482 Br 4CNC6TT4 CH2CH3 4-{[5-(5-bromo-1-ethyl-111-pyrazol-4-yl)-2H- __________ ______ CH2 _____________ tetrazol-2-yl]mcthyl} bcnzonitrile _____________ 483 Br 4CNC6H4 (CH3)2CH 4-({5-[5-brorno-1-(2-methylpropyl)-1[J- CIT2 CM2 pyrazol-4-yl]-2H-tetrazol-2- ______ ____________ _____________ yl} methyl)henzonitrilc ________ 484 Br 4CNC6I-14 CM2Ph 4-{ [5-(1 -beztyl-5-bromo-1H-pyrazol-4-yl)- __________ ______ CT 12 _____________ 21/-tetrazol -2-yl jrnethyl} k19nitri1e 485 Br 4CNC5M4 C6115 4-{[5-(5-bromo-1-phenyl-1H-pyrazol-4-yI)- _________ CH2 ____________ 2H-tetrazol-2-yl]rnethyl} benzonitrile 486 Br 4CNC5H4 2 C1C6I-14 4-({3-[5-bromo-1-(2-ehlorophcnyl)-]H- CT 12 pyrazol -4-y]j-2H-tetrazol-2- ______________ ____________ yl) methyl)henzonitrile ____________________ 487 Br 4CNC6H,1 3 CI C61-14 4-({5-[5-brorno-T-(3-ehlorophenyl)-1II- CH2 pyrazol-4-yl]-21-J-tetrazol-2- ____________ _____________________ _______________ yl) rnethyl)benzonitri Ic 488 Br 4CNC5H 4 Cl C61-h 4-({5-[5-bromo-1-(4-chlorophcnyl)-IH- CH2 pyrazol-4-ylj-2H-tetrazol-2- _________ _________________ ____________ yl)methyl)bcnzonitrile __________________ 489 Br 4CNC6T-T4 2,3 Cl2 4-({5-[5-bromo-1-(2,3-diehlorophenyl)-IJJ- CH2 C6113 pyrazol-4-yl]-211-tetrazol-2- ___________ ______ _____________ _______ yl}methyl)benzonitrile 490 Br 4CNC6H4 2,4 Cl2 4-({5-[5-bromo-1 -(2,4-dicfflorophenyl)-1H- CH2 C61-13 pyrazol-4-yl]-2H-tetrazol-2- __________ ______ ____________ _____________ yl}rnethyl)benzonitrile 491 Br 4CNC6H4 2,5 Cl2 4-({5-[5-bromo-1 -(2,5-dieh1oropheny-1 if- CH2 C6H3 pyrazol-4-ylj-2H-tetrazol-2- __________ ______ ____________ ___________ yl}rnethyl)benzonitrile 492 Br 4CNC6I-14 2,6 Cl2 4-({5-[5-bromo-1-(2,6-dichIorophenv-1 JI- Cl-I2 C6H3 pyrazol-4-yl]-2H-tetrazol-2- ___________ ______ _____________ _____________ yl}rncthyl)bcnzonitrilc 493 Br 4CNC6H4 3,4 Cl2 4-({5-[5-brorno-1-(3,4-dichlorophenv-1H- Cl-I2 C6H3 pyrazol-4-yl]-2H-tetra2ol-2- _________ _____ ___________ _______ y] }methyl)benzonitrile 494 Br 4CNC6114 3,5 Cl2 4-({5-[5-bromo-l -(3,5-dichlorophenyl)-lII- Cl-I2 C6H3 pyrazol-4-yl]-2H-tetrazol-2- ____________ _______ ______________ ________ yl}rnethyl)benzonitrile 495 Br 4CNC6I-14 2 Br C6114 4-({5-[5-bromo-l-(2-bromophenyl)-1iI- CH2 pyrazol-4-ylj-2H-tetrazol-2- ___________ ______ _____________ _____________ yl}methyl)henzonitrile ___________________ 496 Br 4CNC6H4 3 Br C6H4 4-({5-[5-brorno-l-(3-bromopheny-1H- CT-i2 pyrazol-4-yl]-2H-tetrazol-2- __________ ______ ____________ _____________ yl} rnethyl)benzonitrile _________ 497 Br 4CNC6H4 4 Br C61-14 4-({5-15-brorno-l-(4-bromopheny-lH- CH2 pyrazol-4-ylJ-2H-tetrazol-2- ____________ _______ ______________ _______________ yI}methyl)benzoniu'ile 498 Br 4CNC5}-14 4 F C5H4 4-({5-[5-brorno-l-(4-iluorophenyl)-1H- Cl-I2 pyrazol-4-yl]-21J-tetrazol-2- ____________ _______ ______________ _______________ yl} rnethyl)benzonitri le ____________________ 499 Br 4CNC6H4 2 F C6114 4-({5-[5-bromo-1-(2-fluorophenyl)-1H- CH2 pyrazol-4-ylj-2H-tetrazol-2- ______ _____ ___________ ____________ yI}melhyl)benzonitrile 500 Br 4CNC5H4 2,3 (CU3)2 4-({5-[5-bromo-1 -(2,3-dirnethylphenyl)-1H- CIT2 C6113 pyrazol-4-yl]-2H-tetrazol-2- __________ ____________ _____________ yl}methyl)benzonitrile 501 Br 4CNC6I-14 2,4(CH3)2 4-({5-[5-bromo-l-(2,4-dimethylphenyl)-1 H- CU2 C6H3 pyrazol-4-yl]-2H-tetrazol-2- __________ yl}methyl)benzonitrile ________________________ 502 Br 4CNC5114 2,5 (Cu3)2 4-({5-[5-bromo-I-(2.5-dimethylphenyl)-1H- CU2 C6H3 pyrazol-4-yl]-2H-tetrazol-2- ___________ ______ _____________ ______________ yl}methyl)henzonitrile -_________ 503 Br 4CNC6114 2,6 (CU3)2 4-G 5-[5-brorno-I-(2.6-dimethylphenyl)-lIf- CH2 C6H3 pyrazol-4-ylj-2H-tetrazol-2- ____ ________ _____ y[}rnethyl)benzonitrile _________ 504 Br 4CNC6114 3,4 (Cu3)2 4-({5-[5-bromo-1-(3.4-dimethylphenyl)-1H- CH2 C6H3 pyrazol-4-yl]-2J1-tetrazol-2- _______ ______ ____________ _____________ yl} methyl) benzonitrile 505 Br 4CNC6H4 3,5 (CH)2 4-({ 5-[5-brorno-l-(3,5-dimethylphenyl)-1H- CH2 C5H3 pyrazol-4-yl]-211-tetrazol-2- ________ ___________ ____________ yl}rnethyl)henzonitrile 506 Br 4CNC6H4 2CH2CH3 4-({5-[5-brorno-1-(2-ethylphenyl)-TH-pyrazol- __________ ______ CI 2 C6fl4 4-yLJ-2H-tetrazol-2-yl} methyl)henzonitrile 507 Br 4CNC6F14 4CH2CH3 4-( (5-L5-brorno-I -(4-ethylphenyl)-IH-pyrazol- __________ ______ CIT2 C61-14 4-yUJ -2H-tetrazol-2-yl} methyl)henzonitrile 508 Br 4CNC5H4 4 4-({5-[5-bromo-1 -(4-methoxyphenyl)-1H- CH2 OCH3C6H4 pyrazol-4-ylJ-211-tetrazol-2- _________ _____ ___________ ________ yl} methyl)henzonitrile ___________________ 509 Br 4CNC5114 2 C113C6114 4-({5-[5-bromo-1-(2-methylphenyl)-1fI- CU2 pyrazol-4-ylj-2H-tetrazol-2- __________ _____ ___________ ____________ yI} mcthyl)benzonitrilc 5H) Br 4CNC5H4 4 CH3CGH.I 4-({5-45-hrorno-i-(2-methylphenyl)-1H- CM2 pyrazol-4-yl]-211-tctrazol-2- __________ _____ ___________ ____________ y] }methyl)henzonitrile 511 Br 4CH30C6 CR3 5-(5-brorno-1-rnethyl-1H-pyrazol-4-yl)-2-(4- _________ _____ 1-14CH2 ___________ rnethoxybenzvl)-2H-tetrazole 512 Br 4CH30C6 CH2CFI3 5-(5-brorno-1 -ethyl-1H-pyrazol-4-yl)-2-(4-H4CH2 _______ rnelhoxybenzyl)-2H-tetrazole 513 Br 4C1130C6 (CF13)2CH 5-[5-bromo-I -(2-methylpropyl)-1 T/-pvrazol-4- __________ _____ H4CH2 CR2 yl] -2-(4-methoxybenzyl)-2H-tctrazolc 514 Br 4CH30C6 CH2Ph 5-( I -benzyl-5-bromo-I IJ-pyrazol-4-yl)-2-(4- __________ _____ H4CH2 ____________ mcthoxybcnzyl)-211-tctrazolc 5 Br 4CH30C6 CI15 5-(5-brorno--phenyl-I H-pyrazol-4-yl)-2-(4-H4CH2 rnethoxvbenzyl)-2H-tetrazole _____________ 516 Br 4C1130C6 2 C1C6IL 5-j3-hromo-1-(2-chlorophenyl)-1H-pyraz&-4- __________ _____ H4CM2 ____________ yl -2-(4-methoxybenzyl)-2H-tetrazole 517 Br 4CH30C6 3 CI C61-Li 5-[5-hrorno-1--ch1orophcnyI)-1 i1-pyrazol-4- __________ _____ H4CH2 ____________ yl] -2-(4-methoxybenzyl)-2H-tetrazole 518 Br 4CH30C6 4 CI C61-14 5-[5-brorno-1-(4-chlorophenyl)-1//-pyrazoi-4- __________ _____ I 14C1 12 _____________ yfl -2-(4-methoxybenzyl)-2H-tetrazole 519 Br 4CH30C5 2,3 Cl2 5-[5-bromo-1-(2,3-dichlorophenyl)-IH- H4CH2 C6H3 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H- ___________ ____________ tetrazole__________ 520 Br 4C1T30C6 2,4 Cl2 5-[5-bromo-I-(2,4-dichlorophenyl)-1H- H4CH2 C61-13 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H- __________ _____ _____ ______ tetrazole ____________________________ 521 Br 4C1130C6 2,5 Cl2 5-[5-hromo-I -(2,5-dichiorophenyl)-1 H- H4CH2 C6H3 pyrazol-4-ylj-2-(4-methoxybenzyl)-2H- ____________ _____________ tetrazole 522 Br 4C1130C6 2,6 Cl2 5-[5-bromo-1-(2,6-dichlorophenyl)-1H- H4CH2 C6H3 pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H- __________ _____ ____________ _____________ tetrazole 523 Br 4CH30C6 3,4 Cl2 5-[5-bromo-1-(3,4-dichlorophenyl)-1H- H4C112 C5H3 pyrazol-4-yI]-2-(4-methoxybenzyl)-2H-tetrazoic 524 Br 4CH30C6 3,5 Cl2 5-[5-bromo-1-(3,5-dichlorophenyl)-TH- H4CH2 C5H3 pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H- __________ _____ ____________ _____________ tetrazole 525 Br 4CH30C6 2 Br C6I-14 5-[5-brorno-I-(2-bromoplienyl)-IH-pyrazol-4- _____ _____ H4CH2 _____________ yl]-2-(4-rncthoxybenzyl)-2H-tetrazole 526 Br 4C1-130C6 3 Br C6H4 5-[5-brorno-1-(3-bromophenyl)-IH-pyrazol-4- __________ _____ I-14C1-12 _____________ yl]-2-(4-mcthoxybenzyl)-2H-tetrazo!e 527 Br 4CH30C6 4 Br C6H4 5-[5-bromo-I-(4-bromophenyl)-1H-pyrazol-4- __________ _____ H4CR2 _____________ yl]-2-(4-methoxyhenzyl)-2H-tetrazole 528 Br 4CR30C6 4 F C6H4 5 -[5-bromo-1 -(4-fluorophenyl)-1H-pyrazol-4- _________ _____ H4CI-{2 y1]-2-(4-methoxyheny1)-2II-tetrazole 529 Br 4C1-130C6 2 F C414 5-[5-hromo-1-(-fluorophenyl)-1J/-pyrazol-4- __________ H4CI-I2____ _____________ yl]-2-(4-methoxybenzyl)-2H-tetrazole 530 Br 4C1130C5 2.3 (Cl-I3)2 5-[5-brorno-l-(2,3-dimethylphenyl)-IH- H4CR2 C6H3 pvrazol-4-yIl-2-(4-methoxyhenzyl)-2JJ- _________ _____ __________ ___________ tetrazole 531 Br 4C1-130C6 2,4 (CIT3)2 5-[5-bromo-1-(2,4-dirnethylphenyl)-111- H4CF12 C6H3 pyrazol-4-yll-2-(4-methoxybenzyl)-2H- __________ _____ _____________ tetrazole 532 Br 4C1T30C6 2.5 (CR3)2 5-[5-brorno-1-(2,5-dimcthylphcnyl)-1ff- H4CT-12 C6I-T3 pyrazol-4-y1]-2-(4-methoxybenzy-2H- ___________ ______ _____________ _________ tetrazole 533 Br 4CH30C6 2,6 (CIT3)2 5-[5-hromo-1-(2,6-dimethy]phcnyl)-IH- H4CI-12 C6H3 pvrazol-4-yfl-2-(4-methoxyhenzyl)-211- _________ _____ ___________ ______ tetrazole 534 Br 4CH30C6 3,4 (CIT3)2 5-[5-hromo-1-(3,4-dimethylphenyl)-li/- H4CI-12 C6H3 pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H- __________ _____ ____________ tetrazole 535 Br 4CH30C6 3,5 (CR3)2 5-[5-bromo-1 -(3,5-dimethyiphenyl)-1H- H4CI-12 C6H3 pyrazol-4-yl]-2-(4-methoxybenzyl)-2H- __________ _____ ____________ tetrazole 536 Br 4CH30C5 2 CH2CHJ 5-[5-bromo-1-(-ethylphenyl)-1H-pyrazol-4-H4CH2 C6H4 yl] -2-(4-methoxybenzyl)-2H-telrazole 537 Br 4C1T30C6 4 CH2CFI3 5-[5 -bromo-1 -(4-cthylphenyl)-T H-pyrazol-4- _________ _____ H4CH2 C6I14 yfl -2-(4-methoxyhenzyl)-2H-tetrazole 538 Br 4CH30C6 40CR3 5-[5 -brorno-1 -(4-methoxyphenyl)-TH-pyrazol- _________ _____ H4C112 C5H4 4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazole 539 Br 4CH30C6 2 CH3C6H4 5-[5 -bromo-1 -(2-methyiphenyl)-I H-pyrazol -4- _________ _____ H4CH2 ________ yl] -2-(4-methoxybenzyl)-2H-tetrazole 540 Br 4CH30C6 4 CIT3C5TJ4 5-[5-bromo-l -(4-methyiphenyl)-/J-pyrazol-4- _________ _____ H4CH2 -______ yl]-2-(4-rnethoxybenzyl)-2H-tetrazole 541 Br 3CH3C5H4 CH3 5-(5-hromo-1-methyl-I H-pyrazol-4-yl)-2-(3- __________ _____ CH2 _____________ mcthylbcnzyl)-211-tetrazo le _____ 542 Br 3CH3C6H4 Cf-J2CH3 5-(5-bromo-1-ethyl-IH-pyrazol-4-yl)-2-(3- __________ _____ CR2 ____ methylbenzyl)-2H-tetrazole 543 Br 3CTT3C5IL (CIT3)2CTT 5-[5-bromo-1-(2-rnethylpropyl)-1II-pnazol-4- _________ _____ CH2 CR2 yl]-2-(3-methylbenzyl)-2H-tetraiole ________ 544 Br 3CH3C5H4 CH2Ph 5-(1-benzyl-5-bromo-TH-pyrazol-4-yl)-2-(3- _________ _____ CH2 _________ methylbenzyl)-2H-tetrazole 545 Br 3C1-13C51-14 C6115 5-(5-bromo-1 -phenyl-1 H-pyrazol-4-yl)-2-(3- _______ _____ CH2 ____________ rnethylbenzy-2H-tetrazo1e 546 Br 3C113C61I4 2 CIC6T-T4 5-[5-bromo-1-(2-chlorophenyl)-1JI-pyrazol-4- __________ _____ CH2 _____________ yl] -2-(3-rnethylbcnzyl)-2H-tetrazole 547 Br 3CH3C6H4 3 Cl C6H4 5-[5-brorno-1-(3-chlorophenyl)-TH-pyrazol-4- __________ _____ CH2 _____________ yl] -2-(3-rnethylbenzyl)-2H-tetrazole ______ 548 Br 3CH3C6H4 4 Cl C6H4 5-[5-bromo-l-(4-chlorophenyl)-lH-pyrazol-4- _________ _____ CH2 ____________ y1]-2-(3-rnethyibenzyl)-2H-tetrazole 549 Br 3CH3C6H4 2,3 Cl2 5-[5-bromo-l-(2,3-dichlorophenyl)-IH- _________ _____ CH2 C6M3 pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole 550 Br 3CH3C6H4 2,4 Cl2 5-[5-bromo-I -(2,4-dichiorophenyl)-111- _________ _____ CU2 C6113 pyrazol-4-yl]-2-(3-mcthylbenzyl)-2H-tetrazole 551 Br 3CH3C6R4 2,5 Ci2 5-[5-brorno-1-(2,5-dichlorophenyl)-IH- __________ _____ CH2 C6U3 pyrazo I-4-yI]-2-(3-rnethylbenzyl)-21-1-tetrazoie 552 Br 3CH3C6H4 2,6 Cl2 5-[5-bromo-l-(2,6-dichlorophenyl)-1H- _________ _____ CR2 C6H3 pyrazol-4-ylj-2-(3-methylbenzyl)-2H-tetrazole 553 Br 3CIT3C61-14 3,4 Cl2 5-[5-brorno-1-(3,4-dichlorophenyl)-IH- _________ _____ CR2 Cj-13 pyrazol-4-ylj-2-(3-methylbenzyl)-2H-tetrazole 554 Br 3C113C6114 3,5 Cl2 5-[5-hronio-1 -(3,5-dichiorophenyl)-1H- _________ _____ CH2 C6H3 pyrazol-4-yfl-2-(3-methylbenzyl)-211-tetrazole 555 Br 3CU3CJ-14 2 Br C6H4 5-[5-bromo-1-(2-brornophenyl)-AH-pyrazol-4- _______ _____ CH2 ____________ yfl-2-(3-methylhenzvl)-211-tctrazolc 556 Br 3CH3C6H4 3 Br C6H4 5-[5-brorno-l-(3-brornophenyl)-IH-pyrazol-4- __________ _____ CF12 ylj-2-(3 -methylbenzyl)-2H-tetrazole 557 Br 3C113C6114 4 Br C6U4 5-[5-bromo-1-(4-bromophcnyl)-1II-pyrazol-4- _____ C H2 _____________ yij-2-(3-methylbenzyl)-2H-tetrazole 558 Br 3CH3C6H4 4 F C6H4 5-[5-bromo-I-(4-fluoropheny-lH-pyrazoI-4- __________ _____ CIT2 _____________ ylj-2-(3 -methylbenzyl)-2JJ-tctrazolc 559 Br 3CH3C5T-14 2 F C6R4 5-[5-brorno-1-(2-fluorophenyl)-lH-pyrazol-4- __________ _____ CH2 _____________ ylj-2-( -rnethylbenzyl)-2H-tetrazole ____ 560 Br 3CH3C6H4 2,3(CH3)2 5-[5-bromo-1 -(2,3-dimethylphenyl)-1 H- _________ _____ CR2 C6H3 pyrazol-4-yl]-2-(3-methylbenzyl)-2H4etrazole 561 Br 3CH3C6H4 2,4(CH3)2 5-[5-bromo-1 -(2,4-dimethylphenyl)-1 H- __________ ______ CM2 C61-13 pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole 562 Br 3CH3CH4 2,5(CM3)2 5-[5-bronio-I -(2,5-dirnethylphenyl)-I H- __________ ______ CU2 C6113 pyrazol-4-yI]-2-(3-methvlbenzyl)-2H-tetrazole 563 Br 3CH3C6H4 2,6(CU3)2 5-[5-bromo-l-(2,6-dimethylphenyl)-1H- __________ ______ CT-I2 C6H3_______ pyrazol-4-ylj-2-(3 -methylbenzyl)-2H-tetrazole 564 Br 3CF13C5TT4 3,4(CU3)2 5-[5-hromo-I -(3,4-dirnethylphcnyl)-1 TI- __________ ______ CU2 C6113 pyrazol-4-yfl-2-(3 -methylbenzyl)-2H-tetrazole 565 Br 3CH3C6H4 3,5((CH3)2 5-[5-brorno-l-(3,5-dimethylphenyl)-IH- __________ ______ CU2 C6H3 pyrazo l-4-yI]-2-(3 -methylbenzyl)-2H-tetrazole 566 Br 3 CH3C6H4 2CH2CR3 5-[5 -bromo-1 -(2-ethylphenyl)-1H-pyrazol-4- __________ ______ CH2 C6H4 ylj-2-(3 -rnethylbenzyl)-2H-tetrazole 567 Br 3 CH3C6H4 4CH2CR3 5-[5 -brorno-1 -(4-ethylphenyl)-1 H-pyrazol -4- __________ ______ CU2 C61-I4 yl]-2-(3 -rnethylbenzyl)-2H-tetrazole 568 Br 3 CH3C6H4 4 5-[5 -bromo-1 -(4-mcthoxyphenyl)-1H-pyrazol-CH2 OCH3C6H4 4-yl] -2-(3-methylbenzyl)-2H-tetrazole 569 Br 3CT11C6U4 2 CH3C6H4 5-[5-bromo-1-(2-mcthvlphcnyl)-IH-pyrazol-4- __________ ______ CU2 _____________ yll-2-(3 -methylbenzyl)-2H-tetrazole 570 Br 3 CU3C6H4 4 CU3 C5H4 5-15 -brorno-1 -(4-methylphenyl)-1H-pyrazol-4- __________ ______ CT 12 _____________ yfl2(3methyIhcy1)2TT-tctro1e 571 Br 4N02C5H4 CR3 5-(5-brorno-l-melhyl-1H-pyrazol-4-yl)-2-(4- __________ ______ CU2 _____________ nitrobcnzyl)-211-tetrazole 572 Br 4N02C6T-14 CH2CT-T3 5-(5-bromo-1-ethyl-IH-pyrazol-4-yl)-2-(4- _________ _____ Cl-I2 ______ nitrobenzyl)-2H-tetrazole 573 Br 4N07C6H4 (CH,)2CH 5-[5-bromo-l-(2-methy1propv1)-lfJ-prazo1-4- ______ CIT2 CFI7 yl]-2-(4-nitrobcnzyl)-211-tctrazolc 574 Br 4N02C6TJ4 CH2Ph 5-(l-benzyl-5-bromo-IH-pyrazol-4-yl)-2-(4- __________ ______ CIT2 _____________ nitrobcnzyi)-211-tetrazole 575 Br 4N02C6H4 C6M5 5-(5-brorno--phenyl-1 H-pyrazol-4-yl)-2-(4- _________ _____ Cl-I2 _________ nitrobenzyl)-2H-tetrazole 576 Br 4N02C6T-L 2 C1C6TL 5-[5-bromo-1-(2-ehlorophenyl)-Iff-pyrazol-4- _________ _____ CH2 ____________ yl] -2-(4-nitrobenzyl)-2H-tetrazole 577 Br 4N02C6T114 3 Cl C6i-T4 5-[5-bromo-1-(3-chlorophcnyl)-IJI-pyrazol-4- __________ ______ CH2 _____________ yl]-2-(4-nitrobenzyl)-2H-tetrazole 578 Br 4N02C6T14 4 Cl C6ii 5-[5-brortio-I-(4-ch1oropheny1)-1Tf-pyraw1-4- __________ ______ CH7 _____________ yl]-2-(4-nitrobcnzyl)-2H-tctrazole 579 Br 4N02C6H4 2,3 Cl2 5-[5-broino-1-(2,3-dichlorophenyl)-IH- _________ _____ CM2 C6H3 pyrazol-4-yE]-2-(4-nitrobenzyl)-211-tetrazole 580 Br 4N02C61-L 2,4 Cl2 5-{5-bromo-1-(2,4-dichlorophenyl)-1H- _________ _____ CM2 C6H3 ____ pyrazol-4-ylj-2-(4-nitrobenzyl)-2ff-tetrazole 581 Br 4NftC6IL 2,5 Cl2 5-[5-hromo-I -(2,5-diehlorophenyl)-1 H- _____ CM2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 582 Br 4N02C61-14 2,6 Cl2 5-[5-brorno-I -(2,6-dieh!orophcnyl)-1 It- __________ ______ CH2 C61-T3 pyrazol-4-yl]-2-(4-thtrobenzyl)-2H-tefrazole 583 Br 4N02C5H4 3,4 Cl2 5-[5-brorno-l-(3,4-dichlorophenyl)-1H- _________ _____ CT-I2 C61-13 pyrazol-4-yI]-2-(4-nitrobenzyl)-21/-tetrazole 584 Br 4N07C6H4 3,5 Cl2 5-[5-bromo-l-(3,5-dichlorophenyl)-1H- __________ ______ CT-I2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 585 Br 4N02C6H4 2 Br C5H4 5-[5-bromo-1 -(2-bromophcnyl)-1 II-pyrazol-4- __________ ______ CI 12 _____________ yl] -2-(4-nitrobenzyl)-2H-tetrazole 586 Br 4NO2C5T-L 3 Br C5H4 5-[5-brorno-1 -(3-brornophenyl)-1II-pyrazol-4- __________ ______ C1-T2 _____________ ylj-2-(4-nitrobenzyl)-2H-tetrazole 587 Br 4N02C5T-14 4 Br C5H4 5-{5-bromo-1 -(4-brornophenyl)-IH-pyrazol-4- __________ ______ CM2 _____________ yl]-2-(4-nitrobenzyl)-21T-tetrazole 588 Br 4N02C6H4 4 F C5T-L 5-[5-bromo-1 -(4-fluorophenyl)-1 H-pyrazol-4- __________ ______ CM2 _____________ yl]-2-(4-nitrobenzyl)-2H-Lelrazole 589 Br 4NO2C51-T4 2 F C51-14 5-[5-bromo-1-(2-fluorophenyl)-ITJ-pyrazol-4- __________ ______ CIT2 _____________ yfl-2-(4-nitrobcnzyl)-2H-tctrazole 590 Br 4N02C6T-T4 2.3(CT--13)2 5-[5-bromo-1 -(2.3-dirnetEylphenyl)-1H- ____ CH2 C6H3 pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetrazole 59 T Br 4N02C6T T4 2.4(CT 13)2 5-[5-bromo-1 -(2,4-dimethylphenyl)-1 H- _________ _____ CH2 C6H3 pyrazol-4-yij-2-(4-nitrobenzy1)-2H-etrazo]e 592 Br 4N02C61-T4 2.5(CH3)2 5-[5-brorno-1 -(2,5-dimethylphenyl)-1H- _________ _____ CH2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 593 Br 4N02C61T4 2,6(CII3)2 5-[5-brorno-1 -(2.6-dirnethyiphenyl)-111- __________ _____ CM2 C6H3 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 594 Br 4N02C61-14 3,4(CH3)2 5-[5-hromo-I -(3,4-dimethyiphenyl)-il/- __________ _____ CT 2 C6113 pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole 595 Br 4N02C6H4 3,5(CH3)2 5-[5-bromo-1 -(3.5-dimethylphenyl)-TH- _______ ____ Cl-I2 C6H3 pyoI-4-yl]-2-(4-nitrobenzy-2f/-tetrazole 596 Br 4N02C6M4 2CH2CH3 5-15 -bromo-I -(2-ethyiphenyl)-lH-pyrazol-4- __________ _____ CH2 C6H4 yl-2-(4-nitrobenzy1)-2LI-tetrazoIe 597 Br 4N02C6H4 4CH2CH3 5-[5 -bromo-I -(4-ethylphenyl)-1II-pyrazol-4- __________ _____ CIT2 C61T4 vfl-2-(4-nitrobenzyl)-2H-tetrazole 598 Br 4N02C6H4 4 5 -[5 -brorno-1 -(4-mcthoxyphcnyl)-lH-pyrazol- _________ _____ CIT2 OCFI3C5H4 4-yl] -2-(4-nitrobenzyl)-2H-tetrazole 599 Br 4N02C6H4 2CH3C6H4 5-[5-hromo-l -(2-methylphenyl)-1JI-pyrazol-4- _________ _____ CH2 ____________ y]]-2-(4-nitrobcnzyl)-2J1-tetrazole 600 Br 4N02C6H4 4 CHC6I-L 5-[5 -brorno-1 -(4-methyiphenyl)-1 H-pyrazol-4- __________ _____ CH2 _____________ yl] -2-(4-nitrobenzyl)-2H-tetrazole Example 7: S-(5-chloro-1-methyl-IH-pyrazol-4-yl)-2-methyl-211-tetrazole (Compound 61) Step 1: 2-methyl-5-(1 -methyl-i l-I-pyrazol-4-yl)-2H-tetrazole A mixture of 5-(l-rnethyl-IH-pyrazol-4-yl)-2H-tetrazole (100 grn, 06660 moles), potassium hydroxide (74.74 gin, 1.332 moles) and acetonitrile (500 ml) were stirred for 10 mm at 20-25 °C. To the above mixture added methyl iodide (378.12 gm, 2.664 moles), stirred for about 10-15 hour at 20-25°C and progress of the reaction was monitored by HPLC.
Excess acetonitrile was recovered at 60-70°C at reduced pressure. DCM (500 ml) and DM water (500 ml) was added to the reaction mixture, stirred for 30 mm and the reaction mixture was kept undisturbed for 15 mm, The organic layer was separated and aqueous layer was extracted with DCM (500 ml), stirred for 10 mm and separated the final aqueous layer and organic layer. The organic layer was evaporated to obtain the 2-methyl-S-(l-methyl-1H-pyrazol-4-yl)-2H-tetrazole, or I -methyl-5-( I-methyl-IH-pyrazol-4-yl)-21l-tetrazole, or mixture thereof The desired regio-isomer, 2-methyl-5-(1-methyl-IH-pyrazol-4-yl)-2H-tetrazole, was isolated by colunrn chromatography using ethyl acetate and hexane as eluent.
Dry wt 46 gm Yield 0.46 w/w (42%) IIPLC purity 99.97 MP: 172-175°C Step 2: 5-(5-chloro-1 -methyl-1H-pyrazol-4-yl)-2-methyl-2H-tetrazole To a solution of 2-niethyl-5-( I-methyl-I H-pyrazol-4-yl)-2H-tetrazole (10 gm, 0.609 moles) in acetonitrile (50 ml) was added N-ehlorosuccinimide (8.22 gm, 0.0615 moles). The reaction mixture was stirred for 30 mm at 60°C. Progress of the reaction was monitored by HPLC. Excess acctonitrilc was recovered at 40-5OoC under reduced pressure. DI water (100 ml) was poured to the crude product at 20-25 "C. The reaction mixture was stirred for 1 hours at 20-25°C, filtered the product, washed with cold DM water (50 nil) and dried at 60-70°C to obtain the product, 5-(5 -chioro-1-methyl-I H-pyrazol-4-yl)-2-methyl-2H-tetrazole.
Drywt 11gm Yield l.iw/w(91%) HPLC purity: 99.5 1% N4P 125-127°C In accordance with the present disclosure, the halogenations of 2-methyl-5--methyl- 1H-pyra2ol-4-yl)-21-I-tetrazole may preceed the methylation step to obtain the compound of formula I. Example 8; 5-(5-chloro-1-methyl-1H-pyrazol-4-yfl-2-methyl-2H-tetrazole (Compound 61) Step 1: 1-methyl-lIi-pyrazolc-4-carhaldehyde A mixture of phosphoryl chloride (467 gm, 3.045 moles) and DM1-' were stirred ibr 1 hour at 0-5°C. The reaction is exothermic so temperature should be below 5°C. To this slowly added l-methyl-1II-pyrazolc (50 gm, 0.6090 moles) and stirred for 30 mm at 0-5°C.
Then slowly raised the temperature from 20-30°C to 60-70°C and stirred for 10-15 hours.
Progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 0-5°C, to this added ethyl acetate (250 ml), DM water (I L) and aqueous ammonia solution (350 ml, pH-6 to 7). The reaction mixture was stirred for 1 hour at 20-30°C, The inorganic salt obtained was filtered off, washed with ethyl acetate (250 ml). The filtrate was transferred in to a separating funnel. The reaction mixture was allowed to settle. The organic layer was separated and aqueous layer was extracted with ethyl acetate (250 ml). ftc entire organic layer was transferred to the reaction vessel, stirred for 10-15 mm and separated the final aqueous layer and organic layer. The combined organic layer having I -methyl-1H-pyrazole- 4-carbaldehyde and ethyl acetate was used as such for Step 2 without any pun flcation or isolation at this step.
Step 2: 1-methyl -1H-pyrazole-4-earhaldehyde oxirne A mixture of the combined organic layer having 1-methyl-I H-pyrazole-4-carbaldehyde and ethyl acetate obtained from step I, hydroxylamine hydrochloride (63.48 gm, 0.9135 moles) were retluxed at 70-80°C for 2-4 hours. The progress of the reaction was monitored by I-1PLC. The reaction mixture was cooled to 0-5°C, to this added DM water (100 ml) and 25% aqueous ammonia solution (100 ml) at 0-5°C. The reaction mixture was stirred for 10 mm at 20-30 °C. The organic layer was separated and aqueous layer was extracted with ethyl acetate (250 nil). The entire organic layer was transferred to the reaction vessel and washed with 10% brine solution (500 ml). Stirred for 10 mm and separated the final aqueous layer and organic layer. The organic layer was evaporated to obtain the 1-methyl-I Ii-pyrazole-4-carhaldehyde oxi me.
Dry wt: 70 gm Yield 1.40 w/w (90%) HPLC purity 99,85% Step 3: 5-( 1 -methyl-lH-pyrazol-4-yfl-2H-tetrazole 1-methyl-I JJ-pyrazolc-4-carbaldehyde oxime (84 gin, 0.6713 moles) obtained in step 2, ammonium chloride (89.77 gm, 16783 moles), sodium azide (109.11 gin, 1.6783 moles) were taken in DMF (420 nil). The reaction mixture was stirrcd for about 10-12 hours at 100- 120°C. The progress of the reaction was monitored by IIPLC. To the above reaction mixture at 0-10°C, added 1DM water (500 ml). The reaction mixture was stirred for 2 hours at 0-10°C, filtered the product, washed with cold 1DM water (200 ml) and air dried the product, 5-0 -methyl-1H-pyrazol-4-yl)-2H-tetrazole at 60-70°C.
Dry wt 70 gm Yield: 0.83w/w(69%) 1-IPLC purity: 99.98% Step 4: 2-methyl-5-(i -mcthyl-IH-pyrazol-4-yl)-2H-telrazole 2-methyl-5-(1 -methyl-I H-pyrazol-4-yl)-2H-tetrazole was prepared from 5-(1-methyl- 1H-pyrazol-4-yl)-2H-tetrazole as obtained in step 3, by a process of example 7, step I. Step 5: 5-(5-chloro-l -methyl-lH-pyrazol-4-yl)-2-methyl-2H-tetrazole 5-(5-chloro-1 -methyl-1H-pyrazol-4-yl)-2-methyl-2H-tetrazole was obtained by the process as described in step 2 of example 7.
Compounds 62-330 were prepared by following the experimental procedure of Example 7 or 8 using appropriate intemwdiates.
Example 9: 5-(5-chloro-1-methyl-1ff-pyrazol-4-yl)-2-methyl-211-tetrazole (Compound 61) Step 1: 4-iodo-1-methyl-1H-pyrazolc A mixture of l-methyl-1H-pyrazole (7) (37 gm, 0.6090 moles), iodine (57.1 gm, 0.225 moles). hydrogen peroxide (9.2 gin, 0.27 moles) and DI water (110 ml) were stilTed for 24 hour at 20-30°C. Progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 5-10°C. The reaction mixture was quenched with 20% aqueous sodium bisulfate (100 ml) and stirred for I hour at 5-1 0°C. The solid obtained was filtered, washed with cold DI waLer (100 ml) and dried at 40-45°C to obtain the product, 4-iodo-1-methyl-1/f-pyrazoic.
Dry:56gm Yield 1.51 w/w (60%) Step 2: 1-methyl-i H-pyrazole-4-carhonitri Ic To a solution of 4-iodo-1-methyl-1H-pyra2ole (55 gm, 0.264 moles) in N,N-dirnethylacetamide (100 nil), potassium ferrocyanide (24.5 grn, 0.058 moles), palladium (II) acetate (0.592 gm, 0.0026 moles) and sodium carbonate (27.98 gm, 0.264 moles) were added.
The reaction mixture was evacuated and backfihled with nitrogen (3 times). The mixture was stirred for 2 hour at 100-110°C. Progress of the reaction was monitored by HPLC. The reaction mixture was cooled to 20-30°C, to this added Dl water (500 ml), ethyl acetate (500 ml) and stirred for 1 hour at 20-30°C. The reaction mixture was filtered through pad of celite. The organic layer was separated and aqueous layer was extracted with ethyl acetate (200 ml), stirred for 15 miii and separated the final aqueous layer and organic layer. The organic layer was washed with brine solution (200 ml). Ethyl acetate was recovered at reduced pressure at 60-70°C. The mixture was degassed for 2 hour at reduced pressure at 60- 70°C, cooled the mixture to 20-30°C. Hexane (400 ml) was added to the mixture and stirred for 1 hour at 20-30°C. l'he solid product obtained was filtered, washed with cold Dl water (100 nil) and dried at 40-50°C to afford the product, 1-methyl-lI-I-pyrazole-4-carbonitrile.
Drywt:17.94gm Yield: 0.32 w/w (63%); Step 3: 5-( I -methyl-I H-pyrazol-4-yl)-211-tetrazole 1-methyl-lI-l-pyrazole-4-carbonitrile (18 gm, 0.168 moles) obtained in step 2, tn-n-butyl tin chloride (65 gm, 0.218 moles), sodium azide (14 gm, 0.2OImoles) were taken in toluene (180 ml). The reaction mixture was stirred for 24 hours at 100-120°C. The progress of the reaction was monitored by [IPLC. The above reaction mixture was cooled to 10-15°C, to this added 10% ethanolic HC1 solution (100 ml, pH= 1-2). The reaction mixture was stirred for 1-1,5 hours at 10-15°C, filtered off the inorganic salts, washed with ethanol (30 ml). The mother liquor and washings were collected and toluene and eltanol was recovered at 50-55°C at reduced pressure. To the above residue at 20-25°C, added di-isopropyl ether (100 ml), stirred for 1-2 hours at 20-25°C, filtered the solid, washed with di-isopropyl ether (30 ml) and air dried the product, 5-(l-methyl-1H-pyrazol-4-yl)-2H-tetrazole at 60-65°C.
Dry wt: 25 grn Yield: l.4w/w(99%) Theoretical yield: 1.40 w/w Step 4: 2-methyl-5-(t -methyl-i H-pyrazol-4-yl)-2H-tetrazole The preparation of 2-methyl.-5-(l -methyl-1H-pyrazol-4-yl)-2H-tetrazole was carried out in a manner similar to that described in Step I of Example 7.
Step 5: 5-(5-chloro-I-methyl-1 H-pyrazol-4-yl)-2-methyl-2H-tetrazole The 5-(5-chloro-1-methyl-1H-pyrazol-4-yl)-2-mcthyl-2/!-tcfrazoth was synthesized according to the method described in Step 2 of Exampk 7.
Although the subject matter has been described in considerable detail with reference to certain prefelTed embodiments thereof, other embodiments are possible. As such, the spirit and scope of the present disclosure should not be limited to the description of the preferred embodiment contained therein.

Claims (20)

  1. We claim: 1. A compound of formula I, its derivatives, salts, stereo-isomers or rcgio-isorners thereof,NNFormula I wherein: R1 is selected from H, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C17 alkyl; wherein said ailcyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from CI, Br, F, 1, NO2, CN. C15 aiRy]. phenyl, or a C1-C4 alkoxy; and R1 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain a.lkyl is optionally substituted with one or more substituent independently selected from CI, Pr, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, 1, cl_s alkyl, phenyl, or a C1-C4 alicoxy; with the proviso that when R1 is II; R2 is not methyl.
  2. 2. The compound as claimed in claim 1, wherein: R1 is selected from H, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C13 alkyl; wherein said aiRy! is optionally substituted with a phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Br, NO2, cN, c5 alkyl, or a C1-C4 allcoxy; and R3 is selected from a straight or a branched chain c14allcy1; or a C6 aryl group, wherein said straight or branched chain aiRy! is optionally substituted with a phenyl group; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, C12 alkyl, or a c-C4 alkoxy; with the proviso that when R1 is H; R2 is not methyl.
  3. 3. The compound as claimed in claim I, wherein: R1 is selected from Cl, Br or I; R2 is sclcctcd from hydrogcn or a straight chain or a branched C17 alkyl; wherein said aiRy! is optionally substituted with phenyl group; and the substituent when present iii the phenyl group is one or more substituent indcpcndcntly sclcctcd from Cl, Br, F, I, NO2, CN, C15 alIcyl, phcnyl, or a C1-C4 alkoxy; and R3 is selected from a straight or a branched chain Ci7alkyI or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally suhstitutcd with one or more substituent independently selected from Cl, Br, F, I. C15 alkyl, phenyl or a Ci-C4 alkoxy.
  4. 4. The compound as claimed in claim 1, wherein: R1 is selected from Cl, Br or 1; R2 is hydrogen or methyl; and R3 is selected from a straight or a branchcd chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branchcd chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I. or phenyl; said aryl group is optionally substituted with onc or morc substitucnt indcpcndcntly sclcctcd from Cl, Br, F, I, C15 alkyl, or a C1-C4 alkoxy.
  5. 5. The compound as claimed in claim 1 selected from: 5-( i-methyl-I H-pyrazol-4-yl)-2H-tetrazoie; 5-( I-ethyl-I 1-l-pyrazol-4-yl)-2H-tetrazole; 5-[ 1 -(2-methylpropy-I H-pyrazol-4-yl] -2H-tetrazole; 5-( 1 -henzyl-1 H-pvrazol-4-yI)-2H-tctrazolc; 5--phenyl-I 1-I-pyrazol-4-yl)-21-1-tetrazole; 5-[ 1 -(2-chlorophenyl>-IH-pyrazol-4-yl] -2H-tetrazole; 5-[i -(3-chlorophcnyl)-i H-pyrazol-4-yl]-2H-tctrazolc; 5-[1 -(4-chlorophenyl)-11 I-pyrazol-4-yl]-2H-tetrazole; 5-[i -(2,3-dichlorophenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 5 -[1 -(2,4-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(2,5-dichlorophenyl)-1 1-l-pyrazol-4-ylj-2H-tetrazole; 5-El -(2,6-dichlorophenyl)-1 H-pyrazol-4-ylI-2H-tctrazolc; 5-[1 -(3,4-dichlorophenyl)-1 H-pyrazol-4-yfl-2H-tetrazole; 5-[l -(3,5-diehlorophenyl)-l l-l-pyrazol-4-ylj-2H-tetrazole; 5-[ I -(2-bromophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(3-hromophenyl)-1 H-pyraz&-4-yl]-2H-tetrazole; 5-11 -(4-bromophenyl)-11 i-pyrazol-4-yl]-2H-tetrazole; 5-[ I -(4-fluorophenyl)-I H -pyrazcil-4-ylj-2H-tetrazole; 5-[1 -(2-fluoropheny)-1H-pyrazol-4-yl] -2H-tetrazole; 5-[ 1 -(2,3-dimethyiphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[I -(2,4-dimethyIpheny-l H-pyrazol-4-y]j-2!-T-tetrazoie; 541 -( ,5-dirnethylphenyl)-1 M-pyrazol-4-yl]-2F1-tetrazole; 5-fl -(2,6-dimethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[ 1 -(3,4-climethylphenyl)-1 II-pyrazol-4-yl]-21-I-tetrazole; 5-[1-(3,5-dimethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[1 -(2-ethylphenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 5-[ 1 -(4-ethylphenyl)-1 iI-pyrazol-4-yl] -21 1-tetrazole; 541 (4-methoxyphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[I -(2-methy!phenyl)-I H-pyrazol-4-yIJ-2H-tetrazolc; 5-[1 -(4-methylphenyl)-I I-I-pyrazo1-4-y1-2I I-tctrazolc; 5-(5-ehloro-1-methyl-il I-pyrazol-4-yl)-21 1-leirazole; 5-(5-ehloro-1-ethyl-I H-pyrazol-4-yl)-21-I-tctrazolc; 5-[5-chloro-1 -(2-methylpropyl)-1 I-l-pyrazol-4-yIj -2H-tetrazole; 5-(l-benzyl-5-eliloro-l H-pyrazol-4-yI)-2H-ietrazole; 5-(5-chloro-1 -phenyl-1 H-pyrazol-4-yl)-2H-tetrazolc; 5-[5-cliloro-1 -(2 -chiorophenyl)-1 iI-pyrazol-4-yl]-21-I-tetrazole; 5-[5-ehloro-1-(3-chlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[5-ehloro-I -(4-chiorophenyl)-I l-I-pyrazol-4-y[]-21-1-tetrazole; 5-[5-chloro-l-(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[5-ehtoro-] -(2,4-dichiorophenyl)-I H-pyrazol-4-ylj-2N-tetrazole; 5-[5-ehloro-I -(2,5-dich!orophenyl)-1 Fl-pyrazo!-4-yl]-2H-tetrazole; 5-[5-chloro-l-(2,6-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[5-chloro-1 -(3,4-dichlorophenyl)-lH-pyrazol-4-yl]-21I-tetrazole; 5-[5-chloro-1-(3,5-dichlorophenyl)-lII-pyrazol-4-yl]-21I-tetrazole; 5-[1 -(2-bromophenyl)-5-chloro-I H-pyrazol-4-yIj-2H-tetrazole; 5-[1 -(3-bromophcnyl)-5-chloro-1 H-pyrazol-4-yl] -2H-tetrazole; 5-[l -(4-bromophenyl)-5-chloro-1 FI-pyrazol-4-yl] -21-1-tetrazole; 5-[5-ch!oro-1 -(4-fluorophenyl)-1 H-pyrazol-4-yl] -2H-tetrazolc; 5-[S-ehloro-1-(2-fluorophenyl)-IH-pyrazol-4-ylj-2H-tetrazole; 5-[5-chloro-l -(2,3-dimethylpheny[)-1 H-pyrazol-4-yl]-211-tetrazole; 5-[5-chloro-1-(2,4-dirnethylphenyl)-lH-pyrazol-4-yl]-2H-tetrazole; 5-[5-chloro-1 -(2,5-diniethyiphenyl)-I H-pyrazo!-4-yIJ-2H-tetrazo!e; 5-[5-chloro-1-(2,6-dimethylphenyl)-1H-pyrazol-4-yl]-2F1-teirazole; 5-[5-chloro-1-(3,4-dimethylphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 5-[5-ehloro-1 -(3,5-dirneU ylphenyi)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[5--ehloro-1-(2-ethylphenyl)-1H-pyrazol-4-yi]-2H-teii'azole; 5-[5-ehloro-I -(4-ethyiphenyl)-I H-pyrazol-4-yl]-2H-tctrazolc; 5-[5-ehloro-l -(4-methoxyphenyl)-1II-pyrazol-4-yll-21-I-tetrazole; 5-[5 -ehloro-1 -(2-methyiphenyl)-1 1-1-pyrazol-4-yl] -2H-tetrazole; 545-ehloro-I -(4-methylpheny-I l-{-pyrazol-4-yl]-21T-tetrazole; 5-(5 -bromo-1-methyl-i I I-pyrazol-4-yl)-2H-tetrazole; 5-(5-brorno-i-ethyl-I H-pyrazol-4-yl)-2H-tetrazole; 5-[5-bromo-1-(2-methylpropyl)-1 H-pyrazoI-4-yl-2H-tetrazo1e; 5-( I -henzyl-5-bromo-11 1-pyrazol-4-yl)-21H[-tetrazole; 5-(5-bromo-I -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; 5-[5 -brorno-I -(2-chlorophenyl)-1 M-pyrazol-4-yl] -2H-tetrazole; 5-[5-bromo-1 -(3-chiorophenyl)-1 H-pyrazol-4-yl] -21-1-tetrazole; 5-[5-bromo-1 -(4-chiorophenyl)-1 H-pyrazol-4-yl] -2H-tetrazo!e; 545 -bromo-1 -(2,3 -dichlorophenyl)-I H-pyrazol-4-yl]-2H-tctrazole; 5-[5 -brorno-1 -(2,4-dichlorophenyl)-iII-pyrazol-4-ylj-2H-tetrazole; 5-[5-hromo-1 -(2,5-dichlorophenyl)-1H-pyrazol-4-yI]-2H-tetrazole; 5-[5-brorno-1 -(2,6-dichlorophenyl)-I H-pyrazol-4-yI]-2H-tetraz.ole; 5-[5-hrorno-I -(3,4-dichlorophenyl)-III-pyrazol-4-yl]-21-1-tetrazole; 5-[5-brorno-1-(3,5-dichlorophenyl)-1H-pyrazol-4-yI]-2H-tctrazole; 5-[5-brorno-1 -(2-bromophcnyl)-I H-pyrazo1-4-yl-2I-I-tetrazoIe; 5-[5-hromo-I -(3-bromopheny-1II-pyrazo1-4-y1]-2H-tetrazo1e; -[5 -bromo-1 -(4-bromopheny-I H-pyrazol -4-yl] -2H-tetrazole; S-[5-hromo-l -(4-fluorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 5-[5-bromo-1-(2-fluorophenyl)-1iI-pyrazol-4-ylj-2H-tetrazole; 5-[5 -bromo-1 -(2,3 -dimethylphenyl)-1 H-pyrazol-4-yIl-2H-tctrazole; 5-[5-hromo-I -(2,4-dimethy1phcny1)-1H-pyrazo1-4-y1j-2I-I-te1razo1e; 5-[5-bromo-1-(2.5-dimethylphenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 5-L5-brorno-1 -(2,6-dirnethylphenyl)-1 l-!-pyrazol-4-vI]-2H-tetrazole; 5-[5-hromo--(3,4-dirnethylphenyl)-1H-pyrazol-4-yfl-21T-tetrazole; 5-[5-bromo-1-(3,5-dimethylphenyl)-1 H-pyrazol-4-ylJ-2H4etrazole; 5-[5-brorno-1 -(2-ethyiphenyl)-1H-pvrazol-4-yI]-21-T-tetrazole; S 5-[5-bromo-1-(4-ethylphenyl)-1H-pvrazol-4-yl]-2H-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-I H-pyrazol-4-yl] -21-1-tetrazole; 5-[5 -brorno-1 -(2-methyiphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 5-[5 -bromo-I -(4-inethyiphenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; -(5 -iodo-I -methyl-i H-pyrazol-4-yl)-2H-tetrazole; 5-(i -ethyl-5-iodo-lI-i-pyrazol-4-yl)-2H-tetrazole; 5-[5-iodo-I -(2-methylpropyl)-i I-I-pyrazol-4-yl]-2H-tetrazole; 5-(i-benzyl-5-iodo-1i-I-pyrazol-4-yI)-2H-tetrazole; 5-11 -(2-chlorophenyl)-5-i odo-1 H-pyrazol-4-yIj -2H-tetrazole; 5-Li -(3-chlorophenyl)-5-iodo-1 II-pyrazol-4-ylI -2H-tetrazole; 5-[1 -(4-chlorophenyi)-5-iodo-1 H-pyrazol-4-yiI -2H-tetrazole; 5-[i-(2,3-dichlorophenyl)-5-iodo-I H-pyrazol-4-ylj-2H-tetrazoie; 5-Li -(2,4-dichlorophenyi)-5-iodo-1IT-pyrazo!-4-yl]-2H-tetrazole; 5-LI -(2,5-dicbloropbenyl)-5-iodo-i H-pyrazol-4-yl]-211-tetrazole; 5-[i-(2,6-dichlorophenyl)-5-iodo-IH-pyrazol-4-y]]-21-T-tetrazoie; 5-[i-(3,4-dich1oropheny1)-5-iodo-iI-I-pyrazo1-4-y1-2H-tetrazole; 5-LI -(3,5-dichlorophenyl)-5-iodo-i H-pyrazol-4-yll-211-tetrazole; 5-Li -(2-bromophenyl)-5-iodo-1 H-pyrazol-4-yl] -2H-tetrazo Ic; 5-Li -(3-brornophenyl)-5-iodo-11 I-pyrazol-4-yfl -2H-tetrazole; 5-Li -(4-bromophcnyl)-5-iodo-l H-pyrazol-4-yl]-2H-tetrazole; 5-Li -(4-tluorophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tctrazole; 5-LI -(2-Iluorophenyl)-5-iodo-li-I-pyrazol-4-ylj-2F1-tetrazole; 5-[1 -(2,3-clirncthylphenyl)-5-iodo-iH-pyrazol-4-yl]-2H-tetrazoie: 5-[1 -(2,4-dimethylphenyl)-5-iodo-1 H-pvrazol-4-yIl-2H-tetrazole; 5-[I -(2,5-dimethylphenyl)-5-iodo-iH-pyrazoi-4-yi]-2H-tetrazole; 5-[1-(2,6-dimethylphenyl)-5-iodo-1II-pyrazol-4-yi]-21-I-tctrazolc; 5-[ 1 -(3,4-dirnethylphenyl)-5-iodo-1 H-pyrazoi-4-yll-2I1-tetrazole; 5-[l -(3,5-dimethylphenyl)-5-iodo-I H-pyrazoi-4-yij-2H-tetrazole; 5-[ 1 -(2-ethylphenyl)-5-iodo-11 I-pyrazol-4-yfl -21-1-tetrazole; 5-[l-(4-ethylphenyl)-5-iodo-I I-I-pyrazol-4-ylj-211-tetrazole; 5-[5-iodo-1 -(4-rncthoxyphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; -[5 -iodo-1 -(2-methylphenyl)-I H-pyrazo] -4-yl] -2H-tetrazole; and 5-[5 -iodo-1 -(4-methyiphenyl)-1 H-pyrazol-4-yl] -2H-tetrazole;
  6. 6. The compound as cLaimed in claim 1 is selected from: 5-( 1-ethyl-i H-pyrazol-4-yl)-2-mcthyl-2H-tctrazole; 5-( I -ethyl-] H-pyTazol-4-yi)-1 -rnethyl-2H-tetrazole; 2-methyl-S-[1-(2-mcthylpropyl)-IH-pyrazo]-4-yfl-2H-tetrazole; 1-mcthyl-5-[1 -(2-methylpropyl)-l H-pyrazol-4-yl]-211-tetrazole; 5-( 1 -beazyl-1 H-pyrazol-4-yl)-2-rncthyl-2H-tetrazole; 5-(1 -benzyl-H-pyrazol-4-yl)-1 -methyl-211-tetrazole; 2-methyl-5-(1 -phcnyl-iH-pyrazol-4-yl)-2H-tetrazo]e; 1 -rnethvl-5-(1-phenyl-1I1-pyrazol-4-yl)-2H-tetrazo]e; 5-[ 1 -(2-chiorophenyl)-1 H-pyrazol-4-yl]-2-methyl-21 1-tetrazole; S-[1 -(2-chIoropheny-l H-pyraz&-4-vlj-1-methyl-2H-tetrazole; 5 -[1 -(3-chiorophenyl)-1 iI-pyrazol-4-yl]-2-methy]-2H-tetrazole; 5-[l -(3-chIorophenyl)-1H-pyraol-4-y1]-1-rnethy1-2H-tetrazole; 5-[1-(4-chloropbcnyl)-l J-1-pyrazol-4-vlj-2-methyl-2H-tetrazole; 5-[ 1 -(4-chlorophcnyl)-11 I-pyrazol-4-y1]-1 -methyi-2H-tetrazole; 5-[l -(2.3-dich]orophenyl)-1H-pyrazol-4-yl]-2-methvl-2H-tetrazole; 5-[ 1 -(2,3-dichlorophcnyl)-I H-pyrazol-4-yl]-I -rnethyl-2H-tetrazole; 5-[1 -(2.4-dichlorophenyl)-I H-pyrazol-4-vi]-2-mcthyl-2H-tetrazole; -[1 -(2,4-dichlorophenyl)-I H-pyrazo] -4-yl i-i -methyl-21-I-tetrazole; 5-[1-(2,5-dichlorophenvl)-IH-pyrazol-4-yl]-2-rnethvl-2H-teirazole; -[1 -(2,5-dieFflorophenyl)-1 H-pyrazol-4-yfl-1 -methyl-2H-tetrazole; 5-[1 -(2,6-dichlorophenyl)-I H-pyrazo]-4-ylj-2-rnethyl-2H-tetrazoie; S-[1-(2,6-dichlorophenyl)-I H-pyrazol-4-y]]-1 -mcthyl-2H-tetrazole; 5-j i-(3,4-dichlorophenyl)-11 I-pyrazol-4-yfl-2-methyl-21-1-tetrazo Ic; 5-il -(3,4-dich]orophenvl)-1H-pyrazol-4-vl]-1-methyl-2H-tetrazoie; 5-[1 -(3,5-dichlorophenyl)-i H-pyrazol-4-yl]-2-methyl-211-tetrazo]e; 5-El -(3,5-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[I -(2-hromophenyl)-I H-pyrazol-4-yl]-2-rncthyl-2H-tetrazole; 5-[1 -(2-bromophenyl)-1 H-pyrazol-4-yl] -1 -methyi-21 1-tetrazole; 5-[l -(3-bromophenyl)-i H-pyrazo]-4-ylj-2-methyl-2Fi-tetrazole; 5-[1 -(3 -brornophenyl)-1 I-I-pyrazol-4-yl] -1 -methyl-21-i-tctrazole; 5-fl -(4-bromophenyl)-1H-pyrazol-4-yl]-2-methyl-2H-tctrazole; 5-fl -(4-bromophcnyl)-IH-pyrazol-4-ylj-l-methyl-2H-tetrazole; 5-[1-(4-fluorophenyl)-liI-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[ 1 -(4-fluorophenyl)-1 H-pyrazol-4-yl]-1 -methyl-21 1-tetrazole; 5-[1-(2-fluorophenyl)-1H-pyrazoi-4-ylj-2-methyl-21-1-tetrazole; 5-fl -(2-fluorophenyl)-1 I1-pyrazol-4-y[]--mcthyl-2H-tetrazole; 5-fl -(2,3-dimethylphenyl)-IH-pvrazol-4-yl]-2-methyl-211-tetrazole; 5-fl -(2,3-dimethyiphenyl)-1H-pyrazol-4-yl]-1 -mcthyl-21-I-tetrazole; 5-[l-(2,4-dimethylphenyl)-l J-1-pyrazol-4-yl]-2-methyl-2H-tetrazolc; 5-[l-(2,4-dimethylphenyl)-1H-pyrazol-4-yI]-l -methyl-2H-tetrazole; 5-[l -(2,5-dimethylphenvl)-1I-I-pyrazol-4-vl]-2-methyl-21-l-tctrazole; 5-fl -(2,5-dimethylphcnyl)-1H-pyrazol-4-yl]-] -rnethyl-21i1-tetrazole; 5-fl -(2,6-dimethylphenyl)-1H-pyrazol-4-yl]-2-methyl-21-I-tetrazole; 5-[l -(2,6-dimethylphenyl)-l1-I-pyrazol-4-yll-l -methyl-2H-tetrazole; 5-[l -(3,4-dimethyiphenyl)-I H-pyrazol-4-ylj-2-methyl-211-tetrazole; 5-[ 1 -(3,4-dimethylphenyl)-1 1T-pyrazcil-4-yfl-I -methyl-2H-tetrazole; 5-[1 -(3,5 -dirnethyiphenyl)-1 iI-pyrazol-4-yI]-2-methyl -2 1-1-tetrazole; 5-[I -(3,5-dirnethylphenyl)-1 TT-pyrazol-4-yl]-l-methyl-211-tetrazole; 5-[l -(2-ethyiphenyl)-1 II-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-fl -(2-ethylphenyl)-1H-pyrazol-4-yl]-l -methyl-2H-tetrazole; 5-fl -(4-ethyiphenyl)-I H -pyrazol -4-ylj-2-rnethyl-211-tetrazole; 5-fl -(4-ethyiphenyl)-1 H-pyrazol-4-yl] -1 -methyl-21-1-tetrazole; 5-fl -(4-methoxyphenyl)-1H-pyrazol-4-yl]-2-methyl-2H-tetrazolc; 5-fl -(4-methoxyphenyl)-1H-pyrazol-4-yI]-l -methyl-2H-tetrazole; 2-rnethyl-5-[i -(2-rnethylphenyl)-l H-pyrazol-4-yl]-2H-tetrazole; l-mcthyl-5-[l -(2-methyiphenyl)-I H-pyrazol-4-yfl-211-tetrazole; 2-methyl-5-[l-(4-methylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; I -methyl-5-[l -(4-methylphenyl)-l H-pyrazol-4-yl]-2H-tetrazole; 5-(5-chloro-1-methyl-i H-pyrazol-4-yU-2-methyl-2H-tetrazole; 5-(5-ehloro-1-methyl-IT I-pyrazol-4-yl)-I -methyl-2T-T-tetrazole; 5-(5-chloro-I-ethyl-i H-pyrazol-4-yl)-2-methyl-21 1-tetrazo le; 5-(5-chloro-l-ethyl-I H-pyrazol-4-yl)-l-rnethyl-2H-tetrazole; 5-fS-chloro-l-(2-methylpropyl)-1II-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-f5-chloro-I -(2-methylpropyl)-1 H-pyrazol-4-yl]-1-rnethyl-2F1-tetrazole; 5-(1-benzyl-5-chloro-1I4-pyrazol-4-yl)-2-methyl-211-tetrazole; 5-(1-benzyl-3-chloro-1H-pyrazol-4-yI)-1-methyl-2H-tetrazole; 5-(5-chloro-1 pheny1-1I-I-pyrazol-4-yl)-2-methyl-211-tetrazole; 5-(5-chloro-1 -pheny-1H-pyrazol-4-yl)-1-methyl-2H-tetrazole; S 5-[5-ch1oro-1-(2-ch1orophcny1)-1ll-pyrazo1-4-y1]-2-nietby1-2H-tetrazoe; 5-[5-chloro-1-(2-chlorophenyl)-1IT-pyrazol-4-ylJ-1-rncthyl-2H-tetrazole; 5-[5-chloro-1-(3-chlorophenyl)-i H-pyrazol-4-ylj-2-methyl-2F1-tetrazole; 5-[5 -chloro-1 -(3 -chlorophenyl)-1 H-pyrazol-4-yl] -1 -methyl-21 1-tetrazole; 5-[5-chloro-1 -(4-chlorophenyl)-1H-pyrazol-4-y!]-2-rnethyl-2H-ietrazoie; 5-[5-chloro-1 -(4-ch1oropheny1)-1H-pyrazo1-4-y1-1-methy1-2H-tetrazo1c; 5-[5-chloro-1 -(2,3-dichioropheny!)-I H-pyrazol-4-ylj-2-methyl-211-tetrazole; 5-[5-chloro-1 -(2,3-dichiorophenyl)-I H-pyrazol-4-yl]--rnethyl-2H-tetrazole; 5-[5-chloro-1 -(2,4-dichlorophenvl)-1II-pyrazol-4-y!]-2-methyl-2H-tctrazole; 5-[5-chloro-1 -( ,4-dichlorophenvl)-1H-pyra2ol-4-yl]-l -methyl-2H-tetrazole; 5-[5-chloro-1 -(2,3-dich!orophenyl)-1 H-pyrazol-4-ylj-2-methyl-2H-tetrazole; 5-[5-chloro-1 -(2,5-dichlorophenyl)-1FI-pyrazol-4-yl]-1 -methyl-2H-tetrazolc; 5-[5-chloro-1 -(2.6-dichlorophenyl)-1 H-pvrazol-4-yl]-2-rnethvl-211-tetrazole; 5-[5-chloro-1 -(2,6-dichlorophenvl)-1H-pyrazol-4-vIj-I -methyl-2T1-teirazole; 5-[5-chloro-1 -(3,4-dichlorophenyl)-1 H-pyrazol-4-ylJ-2-rncthyl-2H-tetrazole; 5-[5-chloro-1 -(3,4-dichloropheny!)-1 FJ-pyrazol-4-yl]-1-methyl-211-tetrazole; 5-[5-chloro-1 -(3.5-dichlorophcnvl)-1H-pvrazol-4-yI]-2-rnethvl-2H-teirazo]e; 5-[5-chloro-I -(3.5-dichlorophenyl)-1I-i-pyrazol-4-yl]-1-methyl-2H-tetrazole: 5-[1-(2-bromophenyl)-5-ehloro-1H-pyrazol-4-yI]-2-rneiiiyl-2H-tetrazole: I -(2-bromophenv1)-5-ch1oro-1II-pyTazo1-4-v1-1-methy1-2H-tetrazo1c; 5-[1 -(3-hromophenvl)-5-ch!oro-I H-pyrazol-4-ylj-2-methvl-211-tetrazole; 5-[1 -(3-hromophenvl)-5-chloro-I H-pyTazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[1 -(4-bromophenyl)-5-chloro-1fl-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[1 -(4-bromophenvl)-5-chloro-1H-pyrazol-4-ylJ-1 -methyl-211-tetrazole; 5-[5-chloro-1-(4-fluorophenyl)-11-f-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[5-ch1oro-1-(4-fluoropheny1)-11-I-pyrazo1-4-y1]-1-methy1-2IT-tetrazo1e; 5-[5-chloro-1-(2-fiuorophenyl)-1H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[5 -chioro-I -(2-fluorophenyl)-1II-pyrazol-4-ylj -1 -methyl-2 H-tetrazol e; 5-[5-chloro-I -(2.3-dirnethylphenyl)-1II-pyrazol-4-yl]-2-rnethyl-2H-tctrazole; 5-[5-chloro-I -(2,3-dimcthylphcnyl)-1H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-15-chloro-1-(2,4-dirnethylphenyl)-IH-pyrazol-4-yl]-2-methyl-2H-tetraz&c; 5-L5-chloro-1 -(2.4-dimethylphenyl)-I H-pyrazol-4-yl]-i-rnethyl-2H-tetrazole; 5-[5-ehloro-1 -(2.5-diniethylphenyl)-1H-pvrazol-4-yl]-2-methyl-2H-tetrazole; 5-[3-chloro-i-(i5-dimethylphenyl)-1H-pyrazol-4-yl] -1-rnethyi-211-tetrazole; S-[5-chloro-1 -(2,6-dimethylphenyl)-I H-pyrazol-4-y]j-2-rnethyl-211-tetrazole; 5-[5-choro-1-(2,6-dirnedy1pheny1) -iI-I-pyrazo1-4-yfl-1-methyl-2H-tetrazo1e; 5-[5-chloro-1-(3,4-dimethylphenyl)-1H-pyrazol-4-yl]-2-methyl-2] FI-tetrazole; 5-[5-chloro-1 -(3,4-dimcthylphenyl)-1H-pyrazol-4-yi]-1-metliyl-211-tetrazole; 5-[5-ehloro-1 -(3,5-dimcthylphenyl)-H-pyrazol-4-ylj-2-methyl-2H-tetrazole; 5-[5-chloro-1 -(3,5-dimethylphenyl)-iI-1-pyrazol-4-yll-1-rnethyl-2H-tetrazole; 5-[5-ehloro-1-(2-ethylphenyl)-1 H-pyrazo-4-y1]-2-methy1-2I-i-tetrazo1e; 5-[5-chloro-1-(2-ethylphenyl)-1FI-pyrazol-4-yl]-1 -methyl-21--J-tetrazole; 5-[5-ehloro-l -(4-ethylphenvl)-1II-pyrazol-4-ylJ-2-mcthvl-2H-tetrazok; 5-[5-chloro-1-(4-ethylphenyl)-I H-pyrazol-4-yl]-i-methyl-21-1-tetrazole; 545-chloro-1 -(4-methoxyphcnyl)-I H-pyrazo-4-yl]-2-rnethy1-2I1-tetraz&e; 5-[5-ehloro-1 -(4-niethoxvphenyl)-iI1-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-ehloro-I -(2-rnethy1phenyl)-11-1-pyrazo1-4-y1-2-methyI-2H-tetrazoIe; 5-[5 -ehioro-I -(2-methyl phenyl)-I H -pyraiol -4-yl] -1 -methyl-2H-tetrazole; 5-[5-eh]oro-1 -(4-methyiphenyl)-1H-pyrazol-4-yl]-2-methyl-2H-tctrazole; 5-[S-ehloro-i-(4-methylphenyl)-I H-pyrazol-4-y1]-i-methyl-2F1-tetrazole; 5-(5-bromo-1-methyl-i iI-pyrazol-4-yl)-2-mcthyl -2H-tetrazole; 5-(5-hromo-1 -methyl-IH-pyrazol-4-y1)-l -methyl-211-tctrazole; 5-(5-bromo-1-ethyl-1iI-pyrazol-4-yl)-2-methyl-2H-tetrazole; 5-(5-bromo-1 -ethyl-1I-1-pyra2oI-4-yl)-1-rnethyl-2H-tetrazole; 5-[5-hrorno-1 -(2-methylpropyl)-1II-pyrazol-4-yl]-2-rncthyl-2H-tetrazole; 5-[5-bromo-1 -(2-methylpropyl)-I H-pyrazol-4-yl]-i -methyl-2H-tetrazolc; 5-(i-benzy1-5-bromo-1H-pyrazo1-4-y-2-meiFyI-2H-tetrazo1e; 5-(1 -benzyl-5-bromo-1H-pyrazol-4-yl)-1-methyl-2H-tetrazole; 5-(5-bromo-1 -phenyl-1 H-pyrazol-4-yl)-2-rnethyl-2}I-tetrazole; 5-(5-brorno-1-phenyl-11-I-pyrazol-4-yl)-1-methyl-21-I-tetrazole; 5-[5-bromo-1 -(2-chiorophenyl)-1H-pyrazol-4-yfl-2-methyl-21-i-tetrazole; 5-[5 -brorno-1 -(2-chlorophenyl)-I H-pyrazol-4-yl]-1 -rnethyl-2H-tetrazole; 5-[5-bromo-1-(3-chloroplienyl)-1II-pyrazol-4-yl]-2-mcthyl-2H-tetrazole; 5-[5 -bromo-1 -(3 -chlorophenyl)-1 H-pyrazoh4-yl] -1 -methyl-2H-tetrazole; 5-[5-bromo-1 -(4-chiorophenyl)-1 H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[5-brorno-I -(4-ehorophcny-1 I-1-pyrazol-4-yI]-1 -mcthyl-21-I-tctrazole; 5-[5-bromo-1 -(2,3-dichlorophenyl)-11-I-pyrazol-4-yl]-2-rnethyl-21-1-tetrazole; 5-[5-brorno-1 -(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-1 -methyl-21-1-tetrazole; 5-[5-hromo-1 -(2,4-dichiorophenyl)-I H-pyrazol-4-yl]-2-methyl-21-1-tetrazole; 5-[5-brorno-1 -(2,4-dichiorophenyl)-1 H-pyrazol-4-yl] -1 -rnethyl-2H-tetrazole; 5-[5-brorno-I -(2,5-dich1oropheny-1 H-pyrazol-4-yl]-2-rnetliyl-2H-tetrazole; 5-[5-bromo-1 -(2,5-dichiorophenyl)-1H-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-brorno-1-(2,6-dichlorophenyl)-IH-pyrazol-4-yl] -2-rnethyl-2H-tetrazole; 5-L5-bromo-1 -(2,6-dichlorophenyl)-1II-pyrazol-4-yl]-1 -inethyl-211-tetrazole; 5-[5-brorno-1 -(3,4-dichlorophenyl)-1 H-pyrazol-4-yI]-2-rnelhyl-2H-tetrazole; 5-[5-hromo-1 -(3,4-dichlorophenyl)-1 1-1-pyrazo1-4-yI]--methyL-2H-tctrazole; 5-15-bromo-1 -(3,5-dichiorophenyl)-1II-pyrazol-4-yfl-2-methyl-211-tetrazole; 5-[5-brorno-1-(3,5-dichlorophenyl)-1FI-pyrazol-4-yl] -1-rnethyl-2H-tetra2ole; 5-[5-brorno-1 -(2-broniophenyl)-1 H-pyrazol-4-yl]-2-rncthyl-2H-tctrazo!c; 5-[5-brorno-1 -(2-bromophenyl)-lI-I-pyrazol-4-yl]-1 -methyl-21-I-tetrazole; 5-[5-bromo-1 -(3-bromophenyl)-1H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-bromo-1-(3-hromophenyl)-1H-pvrazol-4-yl]-1 -rnethyl-2H-tetrazole; 5-[5 -bromo-I -(4-bromophenyl)-1 H-pyrazol-4-yl] -2-methyl-2F1-tetrazole; 5-[5-bromo-1 -(4-bromophenyl)-I H-pyrazol-4-yfl-1 -rnethyl-2H-tetrazcile; 5-[5-bromo-1 -(4-fluorophcnyl)-1H-pyrazol-4-yl]-2-mcthyl-2H-tctrazolc; 545-bromo-1 -(4-fluorophenyl)-IH-pyrazol-4-ylj-1-rnethyl-2H-tetrazole; 5-[5-bromo-1 -(2-fluorophenyl)-1 H-pyrazol-4-ylj-2-rnethyl-2H-tetrazole; 5-{5-bromo-1 -(2-fluorophenyl)-1H-pyrazol-4-yfl-1 -methyl-2fl-tetrazole; 5-[5 -brorno-1 -(2,3 -dimethyiphenyl)-I H-pyrazol-4-ylj -2-rnethyl-2H-tetrazole; 5-[5-brorno-1 -(2,3-dirnethyiphenvi)-IH-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-[5-bromo-I -(2,4-dimethyiphenyl)-I H-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[5-bromo-1 -( ,4-dirnethylphenyl)-1H-pyrazol-4-yl]-1 -rnelliyl-2H-tetrazole; 5-[5-bromo-1 -( ,5-dimethylphenyl)-1 H-pyrazo!-4-y!J-2-methyl-2H-tetrazole; 5-[3-bromo-1-(2,5-dimethylphenyl)-1 I-I-pyrazol-4-ylJ-1-methyl-21-I-tetrazole; 5-[5-bromo-1 -(2,6-dirnethyiphenyl)-1 H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-bromo-1 -(2,6-dimethylphcnyl)-lII-pyrazol-4-yll-1-mcthyl-211-tctrazole; 5-[5-bromo-1-(3,4-dirnethylphenyl) -1II-pyrazol-4-ylj-2-methyl-211-tetrazole; 5-[5-hromo-1 -(3,4-dimcthvlphcnyl)-1 I-I-pyrazol-4-yll-1 -mcthyl-2H-tetrazolc; 5-[5-bromo-1 -(3,5-dimethylphenyl)-1H-pyrazol-4-yl]-2-rnethyl-211-tetrazole; 5-[5-bromo-I -(3,5-dimetbylpbeny1)-1H-pyrazo1-4-y1]-1-methy1-2Htetrazo1e; 5-[5-brorno-1 -(2-ethyiphenyl)-1II-pyrazol-4-yll-2-methyl-211-tetrazole; 5-[5-bromo-1 -(2-ethylphenyl)-1H-pyrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[5-bromo-I -(4-ethylphenyl)-1 H-pyrazol-4-vI]-2-methyl-2R-tetrazok; 5-[5-brorno-1 -(4-ethylphenyl)-1H-pyrazol-4-vlI-1-mcthyl-21-I-tetrazole; 5-[5-bromo-I -(4-methoxvphenyl)-H-pyrazol-4-yl]-2-methyi-2H-tetrazo]e; 5-[5 -brorno-1 -(4-methoxyphenyl)-I H-pyrazol-4-yl] -1 -rnethyl-2H-tetrazole; 5-[5-brorno-1-(2-methylphenyl)-IH-pyrazol-4-yI]-2-methyl-2H-tetrazole; 5-[5-broino-1-(2-methy1phenv1)-1II-pyrazo1-4-y1-1-methy1-2F1-tetrazo1e; 5-[5-bromo-I -(4-rnethypheny-i H-pyravoI-4-ylJ-2-meihyl-2H-tetrazole; 5-[5-hromo-1 -(4-methyiphenyl)-] H-pyraz&-4-yl]--nicthy]-2H-tctrazole; 5-(5-iodo-1-methyl-1IT-pyrazol-4-yl)-2-methyl-211-tetrazole; 5-(5-iodo-1-rnethyl-IH-pyrazol-4-yl)-1-rnethyl-2H-tetrazole; 5-(l -ethyl-5-iodo-I H-pyrazol-4-y-2-niethy1-2H-tetrazo1e; 5-( 1 -ethyl-5-iodo-I I-I-pyrazol-4-yl)-1 -methyl-21 1-tetrazole; 5-[5-iodo-1 -(2-rnethylpropyl)-1 H-pyrazol-4-yl]-2-methyl-21-T-tetrazole; 5-[5 -iodo-1 -(2-methylpropyl)-1 1-1-pyrazol-4-yl]-1 -methyl-2H-tetrazole; 5-(1-benzyl-5-iodo-1Ii-pvrazol-4-yl)-2-rnethyl-211-tetrazole; 5-(1 -bcnzyl-5-iodo-1 H-pyrazol-4-yl)-I -methyl-2H-tetrazole; 5-(5-iodo-1 -phenyl-1H-pyrazol-4-yl)-2-rnethyl--2H-tetrazolc; 5-(5-iodo-I -pheriyl-1 H-pyrazol-4-yl)-i-methyl-2H-tetrazole; 5-[1 -(2-chlorophenyl)-5-ioclo-1H-pyrazol-4-y!]-2-methyl-2H-tetrazole; 5-Fl -(-ehlorophenyl)-5-iodo-11I-pyrazol-4-yfl-1-methyl-2f1-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-IH-pyrazol-4-ylj-2-methyl-2H-tetrazole; 5-[1 -(3-elilorophcnyl)-5-iodo-1H-pyrazol-4-yI]-1-mcthyl-2H-tctrazole; 5-[1 -(4-chIorophenyl)-5-iodo-11-T-pyrazo1-4-y1-2-methy1-2H-tetrazo1e; 5-[I -(4-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-rnethyl-2H-tetrazole; 5-[1 -(2,3-diehlorophenyl)-5-iodo-I H-pyrazol-4-yI]-2-methy!-21-1-tetrazole; 5-[1-(2,3-dicMorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-methyl-2H-tetrazole; 5-[1-(2,4-dichlorophenyl}-5-iodo-1H-pyrazol-4-ylj-2-rnethyl-2H-tetrazole; 5-[1 -(2.4-diehlorophcnyl)-5-iodo-1II-pyrazol-4-yl]-1-rnethyl-21-I-tetrazole; 5-[1-(2.5-dichlorophenyl)-5-iodo-IH-pyrazol-4-ylJ-2-methyl-2H-tetrazole; 5-[I -(2,5-dichlorophenyl)-5-iodo-IH-pyrazol-4-yl]-1-methyl-2F1-tetrazole; 5-[1 -(2,6-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-211-tetrazole; 5-[l -(2,6-dich]orophenyl)-5-iodo-IH-pyrazol-4-yl]-1-rnethyl-2H-teirazole; 5-[1 -(3,4-dichlorophenyl)-5-iodo-1 I1-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[1 -(3,4-diehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1 -rnethyl-2H-tetrazole; 5-[1 -(3,5-dichlorophenyl)-5-iodo-I H-pyrazol-4-yfl-2-rnetby1-2H-tetrazoe; 5-[1 -(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-1 -methyl-2H-tctrazolc; 5-[1 -(2-brornophenyl)-5-iodo-1 H-pyrazoh4-y]]-2-rnethyl-2H-tetrazoie; 5-[1 -(2-bromophenyl)-5-iodo-1J-i-pyrazol-4-yl]-1-methyl-2H-tetrazole; 5-[1-(3-bromophcnyl)-5-iodo-I H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[1-(3-brornophenyl)-5-iodo-1FI-pyrazol-4-yll-1 -methyl-211-tetrazole; 5-[1-(4-brornophenyl)-5-iodo-1i-I-pyrazol-4-ylj-2-methyl-2H-tetrazole; 5-[1 -(4-bromophenyl)-5-iodo-1 H-pyrazol-4-yI]-I -rncthyl-2H-tetrazole; 5-[1-(4-fluorophenyl)-5-iodo-11-I-pyrazol-4-yI]-2-methyl-2H-tetrazo!c: 5-[ 1 -(4-fluorophenyl)-5-iodo-1 H-pyrazol-4-yl] -1 -methyl-2H-tetrazole; 541 -(2-fluorophenyl)-5-iodo-1H-pyrazol-4-ylj-2-methyl-2H-tetrazole; 5-[1 -(2-fluorophenyl)-5-iodo-I H-pyrazol-4-y!]-1 -methyi-21-T-tetrazole; 5-[1 -(2,3-dirnethylphenyl)-5-iodo-1FI-pyrazol-4-yli-2-metliyl-211-tetrazole; 5-I 1 -(2,3-dirnethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-I -rnethyl-2H-tetrazole; 5-[1 -(2,4-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-methyl-2H-tetrazolc; 5-[1 -(2,4-c1iinethy1pheny)-5-iodo-IH-pyrazo1-4-y1j-1-rnethy1-2H-tetrazo1e; 5-[I -(2,5-dirnethylphenyl)-5-iodo-I H-pyrazol-4-yI]-2-rnethyl-2H-tetrazole; 5-[1-(2.5-dimethylphenyl)-5-iodo-1II-pyrazol-4-yll-1 -methyl-211-tetrazole; 5-[1 -(2,6-dimethylphenyl)-5-iodo-] H-pyravoI-4-yl]-2-rnethyl-2H-tetrazole; 5-[1 -(2,6-dimethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-1 -methyl-2H-tetrazolc; 5-[1 -(3,4-dimethy1pheny1)-5-iodo-11-T-pyrazo1-4-y1]-2-methy1-2IT-tetrazo1e; 5-[1-(3,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-ylj-1 -rnethyl-21-1-tetrazole; 5-[1 -(3,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[1 -(3,5-dimethylphenyl)-5-iodo-11-I-pyrazot-4-yl]-1 -methyl-211-tetrazole; 5-[1-(2-ethy1pheny1)-5-iodo-1H-pyra.zo1-4y1]-2-rnethy1-2H4etrazo1e; 5-[I -(2-ethylphenyl)-5-iodo-I H-pyrazol-4-yl]-I -methyl-2H-tetrazole; 541 -(4-cthylphenyl)-5-iodo-IH-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[l -(4-etbylphenyl)-5-iodo-I I-1-pyrazol-4-yI]-I -methyl-2T-I-tetrazole; 5-15-iodo-1-(4-methoxyphenyl)-1 H-pyrazol-4-yl]-2-methyl-2H-tetrazole; 5-[5-iodo-1 -(4-methoxyphenyl)-I H-pyrazol-4-yI]-1 -methyl-2H-tetrazole; 5-l5-iodo--(2-methy1pheny)-1H-pyrazol-4-yl]-2-rnethyl-2H-tetrazole; 5-[5-iodo-i-(2-methylphenyl)-1 fl-pyrazol-4-yl j-I -rnethyl-2H-tetrazole; 5-[5-iodo-1-(4-methy1pheny)-1H-pyrazo1-4-y1J-2-rnethy1-2II-tetraz&e; 5-15-iodo-l-(4-methylphenyl)-i H-pyrazol-4-ylJ-1-rnethyl-2H-tetrazole; 2-ethyl-5-( i-methyl-i H-pyrazol-4-yl)-211-tctrazok; I -ethyl -5-( I -methyl-i U-pyrazol-4-yl)-211-tetrazole; 2-ethyl-S-( 1-ethyl-i H-pyrazol-4-yl)-2H-tetrazole; 1 -ethyl-5-( i-ethyl-i H-pyrazol-4-y)-2H-tetrazo1e; 2-ethyl-5-[ i -(2-methyipropyl)-I H-pyrazoi-4-yl]-2H-tctrazoie; 1-ethyl-5-[1 -(2-rnethylpropyl)-I H-pyrazoi-4-ylj-2H-tetrazoie; 5-( I -benzyl-1 H-pyrazol-4-yl)-2-ethyl-21-T-tetrazol e; 1 -benzyl-iI-1-pyrazol-4-yl)-i -ethyl-21-l-tetrazole; 2-ethyl-5-( 1 -phenyl-1 H-pyrazol-4-yl)-2I-I-tetrazoie; 1 -ethyl-5-(1 -phenyl-1 H-pyrazoi-4-yl)-2H-tetrazole; 5-li -(2-chiorophenyl)-1II-pyrazol-4-yI]-2-ethyl-211-tetrazo!e; 5-[i-(2-chlorophenyl)-1H-pyrazol-4-vl]-i-ethyl-2H-tetrazole; S-lI -(3 -chiorophenyl)-1 H-pyrazoi-4y1j -2-ethyi-2H-tetrazole; 5-li -(3 -chlorophcnyl)-1 FI-pyrazoi-4-yl] -1 -ethyl-2H-tetrazole; S-Li-(4-ch1oropheny-1H-pyrazoi-4-y1]-2-ethyi-2II-tetrazo1e; 5-[1 -(4-chlorophenyl)-1H-pyrazol-4-yl]-I -ethyl-2H-tetrazole; 5-[i -(2,3-dichlorophenyl)-1 H-pyrazol-4-yl] -2-ethyi-2H-tetrazole; 5-[l -(2,3-dichlorophenyl)-i H-pyrazol-4-yI]-I -eihyl-2H-tetrazole; 5-[i -(2,4-dichlorophenyl)-i H-pyrazol-4-yl]-2-cthyl-2H-tctrazoic; 5-li -(2,4-dichiorophenyl)-1 H-pyrazol-4-yfl-1 -ethyi-211-tetrazoie; 5-[l -(2,5-dichlorophenyl)-i H-pyrazol-4-ylj-2-ethyl-2H-tetrazoie; 5-[i-(2,5-dichlorophcnyl)-TH-pyrazol-4-yl]-I-cthvl-2H-tetrazole; 5-[ I -(2,6-dichlorophenyl)-II I-pyrazol-4-yl]-2-ethyl-2f1-tetrazole; 5-{i-(2,6-dichlorophenyl)-1H-pyrazoi-4-yl]-I-ethyl-2H-tetrazoie; 5-11 -(3,4-dichlorophenyl)-I Ii-pyrazol-4-yl]-2-ethyl-211-tetrazoie; 5-li -(3,4-dichlorophenyi)-1 H-pyrazol-4-yi]-I -ethyl-2H-tetrazole; 5-[i -(3,5-dichlorophenyl)-1 H-pyrazo]-4-yIj-2-cthyl-2H-tetrazole; 5-[ i -(3,5-dichiorophenyl)-1 H-pyrazol-4-yi}-1 -ethyl-2H-tetrazole; 5-il -(2-bromophenyl)-1 H-pyrazol-4-yIj-2-ethyl-21-T-tetrazole; 5-[ 1 -(2-bromophenyl)-1 H-pyrazol-4-yl]-i -ethyl-2H-tetrazole; 5-[1 -(3-hromophenyl)-1H-pyrazol-4-yl]-2-ethyL2II-tetrazole; 5-[i-(3-bromopheny1)-H-pyrazol-4-yi]-1-ethyl-2H-tetrazole; 5-[1 -(4-bromophenyl)-11 I-pyrazo-4-y1] -2-ethyl-2H-tetrazole; 5-[i -(4-bromophenyl)-1H-pyrazol-4-yi]-l -ethyl-2H-tetrazole; 2-ethyi-5-[1 -(4-fluorophenyl)-1 H-pyrazo1-4-y]-2H-tetrazole; 1 -ethyi-5-[1 -(4-fluorophenyl)-l I-I-pyrazol-4-yil -21 1-tetrazole; 2-ethyl-5-[1 -(2-fluorophenyl)-] H-pyrazol-4-ylj-21-I-tetrazole; I -ethyl-5-[1 -(2-fluorophenyl)-1H-pyrazol-4-yi]-211-telzazole; 5-[l-(2,3-dirnethylphenyl)-1H-pyrazol-4-yI]-2-ethyl-2H-Letrazole; 5-Li -(2,3-dimethylphenyl)-1II-pyrazol-4-yl]-1-ethyl-2H-tetrazoie; 5-[ -(2,4-dirnethylphenyl)-lI-1-pyrazol-4-yi]-2-ethyl-2f1-tetrazoie; 5-[i-(2,4-dimethylphenyl)-1H-pyrazol-4-vlJ-I -ethyl-2H-tetrazole; 5-[l-(2,5-dimethylpheny)-Ll-I-pyrazol-4-yIJ-2-ethyI-2T-I-tetrazole; 5-[ i -(2,5 -dirnethyiphenyl)-1 1-1-pyrazol-4-yij-1 -ethyl-21-1-tetrazole; 5-[I -(2,6-dimethylphenyl)-1}-1-pyrazol-4-vi]-2-ethvl-2H-tetrazole: 5-[1-(2,6-dimethylphenyl)-1I-1-pvrazol-4-y!]-I -ethyl-2H-tetrazole; 5-[1 -c,4-dimethylphenyl)-11 I-pyrazoh4-yll-2-ethyL2fI-tetrazole; 5-[l -(3,4-dirnethylphenyl)-I H-pyrazol-4-yI]-l -ethyl-2H-teirazole; S-[1 -c,5-dimethylphenyl)-11 I-pyrazoi-4-yfl-2-ethyk2l 1-tetrazole; 5-fl -(3,5-dimethyiphenyi)-1H-pyrazol-4-yi]-1-ethyl-211-tetraiole; 2-ethyi-5-[1 -(2-ethylpheiiyl)-I H-pyrazol-4-yl]-2F-J-tetrazole; 1-ethyi-5-[1-(2-ethylphenyl)-1IJ-pyrazoi-4-yl]-2H-tetrazole; 2-ethy I-5-[ I -(4-ethylphenyl)-1 H-pyrazol-4-yi]-21-I-tetrazole; 1-ethyl-S-El -( -ethyiphenyl)-1 H-pyrazol-4-y[]-21-I-tetrazole; 2-ethyl-5-[1 -(4-methoxyphenyi)-1 H-pyrazol-4-yi]-2H-tetrazole; I -eihyl-5-[I -(4-mefl oxyphenyi)-1 H-pyrazol-4-yi]-21-I-tetrazole; 2-cthyl-5-[1 -(2-methyiphenyl)-1 H-pyrazoi-4-ylj-21-1-tetrazoie; 1-ethyl-5-[1 -(2-methyiphenyl)-I 1-l-pyrazo[-4-yIl-21-T-tetrazo!e; 2-ethyl-5-[1 -(4-rnethylphenyl)-1H-pyrazol-4-y]j-2H-tetrazoie; I -ethyl-5-[I -(4-methyiphenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 5-(5 -chioro-1-methyl-i FI-pyrazoi-4-yl)-2-ethyl-211-tetrazole; 5-(5-chloro-I -methyl-I H-pyrazol-4-yI)-l -ethyl-2H-tetrazole; 5-(5-chloro-1 -ethyl-1I-l-pyrazol-4-yl)-2-ethyl-21 l-tetrazoie; 5-(5-chloro-I -ethyl-I H-pyrazol-4-yl)-l-ethyl-21-l-tetrazoie; 5-[5-cliJoro-1 -(2-methyipropyl)-1 H-pyrazol-4-yl]-2-ethyl-21I-tetrazole; 5-[5-chloro-I -(2-rnethylpropyl)-1H-pyrazol-4-ylj-1 -ethyl-2H-tetrazole; 5-( 1 -benzyl-5-chloro-I H-pyraz&-4-yI)-2-ethyl-211-tetrazole; 5-0 -benzyl-5-chloro-1FI-pyraz&-4-yl)-i-ethyl-2H-tetrazole; 5-(5-chloro-I -phenyl -1 H-pyrazol-4-yl)-2-ethyl-21 1-tetrazole; 5-(5-chloro-1 -phenyl-1II-pyrazol-4-yl)-I -ethvl-2H-tetrazole; 5-[5-chloro-l -(2-ehIorophenv1)-1H-pyrazo1-4-y1-2-ethyl-21-I-tetrazoie; 5.[5-chIoro-1 -(2-ehiorophenyl)-I H-pyrazol-4-yI J-1 -cthyl-211-tetra.zole; 5-15-chloro-1 -(3-ehlorophenyl)-1H-pyrazol-4-vl]-2-ethyl-2H-tetrazole; 5-[5-chloro-1 -(3-ehlorophenyl)-i H-pyrazol-4-yl]-1-ethyl-2H-tetrazole: 5-[5-chloro-1 -(4-chlorophenyl)-1 II-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-1 -(4-chlorophenyl)-IH-pyrazol-4-yl]-1-ethyl-2H-tctrazole; 5-[5-chloro-1-(2,3-dichlorophenyl)-l H-pyrazol-4-yl]-2-ethyl-211-tetrazolc; 5-[5-chloro-1 -(2,3-dichlorophenyl)-1H-pyrazol-4-yI]-i -ethyt-2H-tetTazole; 5-[5-chloro-i -(2,4-dichlorophenyl)-1H-pvrazol-4-yl]-2-cthyl-2H-tetravo]e; 5-[5-chloro-1 -(2,4-dichloropheriyl)-1 H-pyrazol-4-yll -1 -ethyl-2H-tctrazolc; 5-15-chloro-1 -(2,5-dichlorophenyl)-1 H-pyravni-4-yl]-2-ethyl-211-tetrazole; 5-[5-chloro-1-(2,5-dichlorophenyl)-1II-pyrazol-4-yI]-1 -ethyl-2H-tetrazole; 5-[5-chloro-1 -(2,6-dichiorophenyl)-H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chioro-1 -(2,6-dich1oropheny1)-1FI-pyrazo1-4-y1-1 -ethyl-2H-tetrazoic; 5-[5-chloro-i -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-ethyl-211-tetrazole; 5-[5-ehloro-l -(3,4-dichlorophenyl)-1 I-I-pyrazol-4-yl]-I -ethyl-2H4elrazole; 5-[5-chloro-1 -(3,5-dichlorophenyl)-1II-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-l -(3,5-dichlorophenyl)-1H-pyrazol-4-yl]-1 -ethyl-2H-tctrazole; 5-[1 -(2-brornophenyl)-5-chloro-I fl-pyrazol-4-ylj-2-ethvl-2H-teirazole; 5-[ I -(2-bromophenyl)-5-chloro-1II-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[I -(3-brornophenyl)-5-chloro-11-I-pyTazol-4-yUf-2-ethyl-2H-tetrazolc; 5-[1 -(3-bromophenyl)-5-chloro-I T-1-pyrazol-4-yl] -1 -ethyl-2F1-tetrazole; 5-Li -(4-bromophenyl)-5-chloro-1I1-pyrazol-4-yl]-2-cthyl-2H-tetrazo[e; 5-[1 -(4-bromophonyl)-5-chloro-IH-pyrazol-4-yIj-1-ethyl-211-tetrazole; 5-[5-ehioro-1-(4-fluorophenyl)-1H-pyrazol-4-yI]-2-ethyl-2H-tetrazole; 5-[5 -chloro-I -(4-fluorophenyl)-1 I-1-pyrazol-4-ylJ-1 -ethyl-21-1-tetrazole; 5-[5-ehloro-1-(2-fluorophenyl)-1IT-pyrazol-4-ylJ-2-ethyl-2H-tetrazole; 5-[5-ehloro-I -(2-fluorophenyl)-1I-{-pyrazol-4-ylj-1 -ethyl-211-tetrazole; 5-[5-chloro-1 -(2,3-dimethylphenyl)-1II-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-1-(2,3-dimethylphenyl)-1H-pyrazol-4-yl]-1-ethyl-2H-tetrazole; 5-[5-chloro-1 -(2,4-dimethylphenyl)-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-1 -(2,4-dimethylphenyl)-1H-pyrazol-4-yl]-1-ethyl-2H-tetrazole; 5-[5-chloro-1 -(25-dirnethylphenyl)-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-chloro-1 -(2,5-dimethylphenyl)-1 H-pyrazol-4-yl]-1-ethyl-2H-tetrazole; 5-[5-cbloro-1 -(2.6-dimethypheny1)-I H-pyrazo1-4-yI]-2-ethy-2H-tetrazo1e; 5-[5-chloro-] -(2,6-dimethy1pheny)-i H-pyrazo1-4-yl]-1-ethy-2H-tetrazole; 5-[5-chloro-1 -(3.4-dirnethy1phenyI)-1H-pyrazoI-4-yI]-2-ethyI-2H-tetrazoe; 5-[5-ch1oro-1-(3.4-dimethy1pheny1)-1II-pyrazo1-4-y1-1-ethy1-2I1-tetrazo1e; 5-[5-chloro-1-(3.5-diniethylphenyl) -1H-pyrazol-4-ylj-2-ethyl-21-1-tetrazole; 5-[5-chloro--(3,5-dimetbyiphenyl)-1H-pyrazol-4-yl]-l-ethyl-2i-i-tetrazoie; 5-[5 -chloro-1 -(2-ethyiphenyl)-I H-pyrazo l-4-yI] -2-ethy!-21-i-tetrazole; 5-[5-chloro-1-(2-ethylphenyl)-IH-pyrazol-4-ylJ-l-ethyl-2H-tetrazole; 5-[5-eh1oro-1-(4-ethy1pheny1)-1H-pyrazo1-4-y1]-2-ethy12H-tetrazole; 5-[5-ch!oro-1 -(4-ethylphenyl)-1 H-pyrazol-4-yl]-I -ethy!-21-I-tetrazole; 5-[5-chloro-1 -(4-rnethoxyphenyl)-1H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5 -ehioro-1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl] --ethyl-2H-tetrazole; 5-[5-chloro-1-(2-methylphenyl)-1H-pyrazol-4-yl]-2-ethyl-2H-letrazole; 5-[5-ch1oro--(2-methylphenyl)-1 H-pyrazol-4-yfl-1 -ethyl-2H-tetra'io!e; 5-[5-effloro-1 -(4-rnethypheny1)-1H-pyrazol-4-yl]-2-ethyl-21-1-tctrazole; 5-[5-effloro-l -(4-methyiphenyl)-1H-pyrazol-4-ylj-1 -ethyl-2E1-tetrazole; 5-(5-brorno-1 -methyL-I}-l-pyrazol-4-yI)-2-ethyl-2H-tetrazole; 5-(5-hromo-1 -methyl-I I-I-pyrazo1-4-y)-1 -ethyl-2H-tetrazole; 5-(5-bromo-1-ethyl-i I-I-pyrazo1-4-y)-2-ethy1-2I-I-tetrazo1e; 5-(5-brorno-1-ethyl-IH-pyrazol-4-yl)-i-ethyl-2H-tetrazole; 5-[5-bromo-I -(2-methyipropyl)-I 1-1-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-bromo-1 -(2-methyipropyl)-1 H-pyrazol-4-yl] -1 -ethyl-2H-tetrazole; 5-( 1-benzyl-5-bromo-I H-pyrazo-4-yl)-2-ethy-2H-tetnzoIe; 5-( 1 -benzyl-5-bromo-1 H-pyrazol-4-yl)-1 -ethyl-2H-tetrazole; 5-(5-bronio-1 -phenyl-1 H-pyrazoi-4-yl)-2-ethyl -21-T-tetrazole; 5--bromo-1 -phenyi-1 H-pyrazol-4-yl)-1 -ethyl-2H-tetrazole; 5-[5-bromo-1-(2-chlorophenyl)-1IT-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-hromo-1-(2-chlorophcnyl)-1H-pyrazol-4-yi]-1-ethyl-2H-tetrazole; 5-[5-bromo-1-(3-chlorophenyl)-1II-pyrazol-4-yl]-2-ethy!-2ll4etrazole; 3-[5 -bromo-1 -(3 -chlorophenyl)-114-pyrazol-4-yl] -1 -ethyl-2H-tetrazole; 5-[5 -brorno-1 -(4-chiorophenyl)-1 I-1-pyrazol-4-yl] -2-cthyl-2H -tetrazole; 5-[5-bronio-1 -(4-chiorophenyl)-11-T-pyrazol-4-yl] -1 -ethyl-211-tetrazole; 5-[5-bromo-1-(2.3-dichlorophenyl)-1 H-pyrazo1-4-yj-2-ethy1-2H-tetrazo1e; 5-L5-brorno-1-(2,3-dich1oropheny1)-1H-pyrazo1-4-y1-1 -ethyl-21-1-tetrazolc; 5-[5-bromo-1-(2,4-dichlorophenyl)-1!-I-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[5-bromo-l -(2,4-dichlorophenyl)-1H-pvrazol-4-yl]-l -ethyl-2H-tetrazolc; 5-{5-bromo-1-(2,5-dichlorophcnvl)-1H-pyrazo!-4-yl]-2-ethyI-2H-tetrazole; 5-[5-hromo-1 -(2,5-clichlorophenvl)-1II-pyrazol-4-yl]-1 -ethyl-2H-tctrazolc; 5-[5-bromo-l-(2,6-clichloropheriyl)-1 H-pyrazo1-4-y1-2-ethy1-2II-tetrazo1e; 5-15-bromo-l-(2,6-dichlorophenyl)-1H-pyrazo!-4-y[]-1 -ethyl-2H-tetrazole; 5-L5-bromo-1 -(3,4-dichlorophenyl)-1 H-pyrazol-4-yl]-2-cthyl-2H-tetrazole; 5-[5-brorno-1 -(3,4-dichloropheriyl)-1H-pyrazo1-4-y1-1 -ethyl-211-tetrazole; 5-[5-bronio-1 -(3,5-clichlorophenvl)-1H-pyrazol-4-yI]-2-ethyl-2H-tetrazole; 5-[5-bromo-1 -@ ,5-dichlorophenyl)-I T-I-pyrazol-4-yl]-I -ethyl-2H-tetrazole; 5-[5-brorno-l -(2-brornophenyl)-1 H-pyrazol-4-yfl-2-ethvl-21-I-tetrazole; 5-[5-bromo-1-(2-brornophenyl)-1 H-pyrazol-4-yl]-1 -ethyl-21-J-tetrazole; 5-[5-brorno-l -(3-brornophenyl)-1F1-pyrazol-4-yfl-2-ethyl-21-I-tetrazole; 5-[5-hromo-1 -(3-brornophenyl)-I H-pyrazol-4-vl]-l-etliyl-2H-wtrazole; 5-[5-bromo-1-(4-brornophcnyl)-1 H-pyrazoi-4-yI]-2-ethvl-2H-tetrazole; 5-L5-bromo-1 -(4-brornophenyl)-1fI-pyrazol-4-yl]-l -eihyl-2H-tetrazole; 5-15-brorno-1 -(4-fiuorophenyl)-1 H-pyrazol-4-ylj-2-ethyl-2H-tetrazole; 5-15-bromo-1-(4-fluorophenyl)-IH-pyrazol-4-yI]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1-(2-fluorophenyl)-IH-pyrazol-4-yl]-2-cthyl-2H-tetrazole; 5-[5-brorno-I -(2-fluorophenyl)-I H-pyrazol-4-yl]-I -ethyl-211-tetrazole; 5-[5-bromo-1-(2,3-climethylphenyl)-I H-pyrazo!-4-yl]-2-ethyl-2H-tetrazole; 5-L5-bromo-1 -(2,3-dimethyiphenyl)-I H-pyrazol-4-yI]-I -cthyl-2T-J-tctrazole; 5-[5-hromo-I -(2,4-dirnethyiphenyl)-IH-pyrazol-4-yl]-2-elhvl-2H-tetrazole; 5-L5-bromo-1-(2,4-dimethylphenyl)-1ll-pyrazol-4-vI}-I-ethyl-2H-tctrazolc; 5-L5-brorno-1 -(2,5-dirnethyiphenyl)-1H-pyrazol-4-yl]-2-ethyl-21I-tetrazole; 5-[5-bromo-1-(2,5-dimethylphenyl)-I fl-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-bromo-1 -(2,6-dimethylphenyl)-1 H-pyrazol-4-yll -2-ethyl-21 1-tetrazole; 5-15-bromo-1-(2,6-dimethy!phenyD-I H-pyrazol-4-y]j-I -cthy]-2H-tetrazole; 5-[5-hrorno-1-(14-dimethylphenyl)-1II-pyrazol-4-yI]-2-ethyl-2H-tetrazole; 5-[5-bromo-I -(3,4-dimethylphenyl)-1H-pvrazol-4-yl]-1-ethyl-211-tetrazole; 5-[5 -brorno-1 -(3.5-dimethylphenyl)-I H-pyrazol-4-ylj-2-ethyl-2H-tetrazole; 5-[5-brorno-1-(3,5-dimethy1pheny1)-1H-pyrazo1-4-y1-1-ethyl-2H-tetrazo1e; 5-[5-bromo-1-(2-cthylphenyl)-I H-pyrazol-4-ylj-2-ethyl-21-I-tetrazole; 5-[5-bromo-1-(2-eihylphenyl)-1H-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[5-brorno-1-(4-ethylpbenyi)-i I-1-pyrazol-4-yl]-2-ethyl-211-tetrazole; 5-[5-bromo-I -(4-ethylphenyl)-I T-1-pyrazol-4-yll-1-ethyl-211-tetrazole; 5-[5-bromo-1-(-methoxypheny1)-1H-pyrazol-4-yI]-2-eihyI-2H-telrazo1e; 5 -[5 -brorno-1 -(4-methoxyphenyl)-1 II-pyrazol-4-yl] -1 -ethyl-2F1-tctrazole; 5-[5-hrorno-I -(2-rnetliylphenyl)-IH-pyrazol-4-yfl-2-ethyl-211-tetrazole; 5-[5-hromo-I -(2-methylphcnyl)-1H-pyrazol-4-yl]-1-ethyl-2}-I-tetrazole; 5-[5-bromo-1-(4-methylphenyl)-1 H-pyrazol-4-yI]-2-ethyl-2H-tetrazole; 5-[5 -brorno-1 -(4-rnethylphenyl)-1H-pyrazol-4-yl] -1 -ethyl-21 1-tetrazole; 2-cthv1-5-(-iodo-1-methy1-1H-pyrazo1-4-y1)-2H-tetrazo1e; I -ethyl-5-(5-iodo-I -methyl-I R-pyrazol -4-yl)-2H-tctrazole; 2-ethyl-5-(1-ethyl-5-iodo-1II-pyrazol-4-yl)-2H-tetrazole; 1-ethyl-5-(1 -ethyl-5-iodo-1 T-T-pyrazol-4-yI)-21T-telra-zole; 2-ethyl-5-[5-iodo-1-(2-methylpropyl)-1H-pyrazol-4-y1]-2H-tetrazole; 1 -ethyl-5-[5-iodo-I -(2-niethylpropyl)-1I-I-pyrazol-4-yl]-211-tetrazole; 5-(1 -bcnzvl-5-iodo-1I-1-pyrazol-4-yI)-2-ethyl-2H-tetrazole; 5-( 1 -benzyl-5 -iodo-I H-pyrazol-4-yl)-1 -ethyl-21 1-tetrazole; 2-ethyl-5-(5-iodo-I -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; 1 -ethyl-5-(5-iodo-I -phenyl-1 H-pyrazol-4-yl)-2H-tetrazofe; 5-[1-(2-chlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2-ethyl-2H-tctrazole; 5-11 -(2-chlorophenyl)-5-iodo-1 F-1-pyrazol-4-ylj -1 -ethyl-2H-tetrazole; 5-[I -(3-chlorophenyl)-5-iodo-1H-pyrazol-4-ylj-2-ethvl-2H-tetrazole; 5-[1-(-chloropl1enyl)-5-iodo-1II-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[1-(4-chlorophenyl)-5-iodo-IH-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[1-(4-chlorophenyl)-5-iodo-1i1-pyrazol-4-yl]-1 -ethyl-2H-tetrazole; 5-[1 -(2,3-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-11 -(2,3-dich1oropheny1)-5-iodo-1T-1-pyrazol-4-yl-I -ethyl-2H-tetrazole; 5-[1 -(2,4-dichlorophenyl)-5 -iodo-1 H-pyrazol-4-yl] -2-ethyl-2F1-tctrazole; 5-11 -(2,4-diehlorophenyl)-5-iodo-IH-pyrazol-4-yI]-I -etbyl-2H-tetrazole; 5-[1-(2,5-dichlorophcnyl)-5-iodo-1H-pyrazol-4-yll-2-ethyl-2H-tctrazole; 5-[1 -(2,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-ylj-1-ethyl-211-tetrazole; 5-[i -(2,6-diclilorophcnyl)-5-iodo-1II-pyrazol-4-yl]-2-ethyl-2H4etrazole; 5-[I -(2,6-dichlorophcnyl)-5-iodo-1H-pyrazol-4-yl]-1-ethyl.-2fl-tetrazolc; 5-fl -(3.4-dichlorophenyl)-5-iodo-1H-pyraz&-4-yfl-2-ethyl-2H-teirazole; 5-[1-(3,4-dichlorophenyI)-5-iodo-1H-pyrazol-4-y1-1-ethy1-2H-tctrazo1e; 5-fl -(3.5-dichlorophenyl)-5-iodo-l H-pyrazol-4-y]j-2-ethyl-2H-tetrazole; 5-[1-(3.5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-1-ethyl-2H-tctrazole; 5-fl -(2-bromophenyl)-5-iodo-1II-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[1 -(3-bromophcnyl)-5-iodo-N-pyrazol-4-yli-2-ethyl-2H-tetrazolc; 5-fl -(3-bromophenyl)-5-iodo-1H-pyrazol-4-yI]-1 -ethyl-2H-tetrazole; 5-[l -(4-hromophenyl)-5-iodo-1 II-pyrazol-4-yl]-2-ethyl-2H-tetraz&e; 5-[ 1 -(4-brornophcny!)-5 -iodo-] U-pyrazol-4-yll-1 -ethyl-2H-tetrazolc; 2-ethyl-5-[1 -(4-fluorophcnyl)-5-iodo-1 H-pyrazol-4-yll-211-tetrazole; I -ethyl-5-{ 1 -(4-fluorophenyl)-5 -iodo-T-i-pyrazo1-4-y1 -2H-tetrazole; 2-ethyl-5-[1 -(2-fiuoropheny1)-5-iodo-lII-pyrazo!-4-y-2H-tetrazo1e; 1-ethyl-5-[1 -(2-fluorophcny)-5-iodo-1 H-pyravo]-4-y]-2H-tetrazo1e; 5-[1 -(2,3-dirnethvlphenyl)-5-iodo-1H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[l -(2,3-dimethylphenyl)-5-iodo-I H-pyrazol-4-yl]-1-ethyl-2H-tetrazole; 5-[1-(2,4-dirnetlwlphenyl)-5-iodo-1H-pyrazo!-4-yl]-2-cthyl-2H-tetrazole; 5-[1 -(2,4-dirncthylpheny1)-5-iodo-1H-pyrazo1-4-y1-l-cthy1-2TT-tetrazoIe; 5-{1-(2,5-dimethy1pheny)-5-iodo-IH-pyrazol-4-yl]-2-ethyl-2H-tctrazole; 5-[1-(2,5-clirneihylphenyl)-5-iodo-1H-pyrazol-4-yfl-1 -ethyl-2H-tetrazole; 5-[1 -(2,6-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-ethyl-2H-tetrazole; 5-[l -(2,6-dirncthylphenyl)-5-iodo-1 H-pvrazol-4-yll-l-ethyl-2H-tetrazolc; 5-Fl -(3,4-dimethylphenyl)-5-iodo-I H-pyrazol-4-ylj-2-ethyl-211-tetrazole; 5-[ 1 -(3,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yI]-I -ethyl-2H-tetrazole; 5-[1 -(3,5-dimcthylphenyl)-5-iodo-11-1-pyrazol-4-y1-2-ethy1-2ll-tetrazoIe; 5-[1 -(3,5-dirnethylphenyl)-5-iodo-l 1-T-pvrazo]-4-yl]-2-ethyl-2H-telrazole; 2-ethyl-5-[1 -(2-e.thyIpheny1)-5-iodo-1H-pyrazo1-4-y1-2H-tetrazoIe; 1 -ethyl-5-[1 -(2-ethylphenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 2-cthyl-5-[1 -(4-ethylphenyl)-5-iodo-1II-pyrazol-4-yI]-2H-tctrazole; I -ethyl-5-[1 -(4-ethylphenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 2-ethy1-5-[5-iodo-1-(4-mcthoxyphenv)-l FT-pyrazol-4-yll-2H-tetrazole; 1-ethyl-5-[5-iodo-1-(4-rnethoxyphenyl)-1H-pvrazol-4-ylj-2H-tetrazole: 2-ethyl-5-[5-iodo-I -(2-niethylphenyl)-1 H-pyrazol-4-yfl-2H-tetrazole; 1-ethvl-5-{5-iodo-I-(2-methylphenyl)-1 H-pyrazol-4-yl]-2H-tetr'azole; 2-ethyl-5-[5-iodo-1 -(4-niethypheny1)-1H-pyrazol-4-y11-2i-I-tetrazo1e; 1 -ethy1-5-[5-iodo-1-(4-methy1pheny)-I H-pyrazol-4-yl]-2H-tetrazole; 2-( 1-methyl ethyl)-5 -( -methyl-I H-pyTazol-4-yl)-21 1-tetrazole; 1-(1 -methylethyl)-5-(l-methyl-1H-pyrazol-4-yI)-2H-tcirazo]c; 5-( 1-ethyl-i Il-pyrazo I -4-y1)-2( 1 -rnelhylethyl)-21-I-tetrazole; 5-( 1-ethyl-i H-pyrazol-4-yl)-1 -( I -methylethyl)-2F1-tetrazole; 2-( I -methylethyl)-5-[l -(2-methyipropyl)-1 l-I-pyrazol -4-yl] -2H-tetrazole; 2-(l -methylethyl)-5-[1 -(2-niethylpropvl)-1II-pyrazol-4-yl]-2H-tctrazole; 5-@ -benzyl-iH-pyrazol-4-yI)-2-(1 -methylethyl)-21-I-tetrazole; 5-( 1 -benzyl-1 I-I-pyrazol-4-yl)-1-(l -methylethyij-2H-tetrazole; 2-(I -methylethyl)-5-( i -phenyl-1 II-pyrazol-4-yl)-2H-tctrazole; 1 -(1 -methylethyl)-5-( 1 -phenyL-I H-pyrazol-4-yl)-21-I-tetrazole; 5-[1 -(2-ehlorophenyl)-iIl-pyrazol-4-yl]-2-(l-methylethyl)-2H-tetrazole; 5-[1 -(2-ehlorophenyl)-1H-pyrazol-4-yl]-l-(l-methylethyl)-2i-1-tetrazole; 541 -(3-chlorophenyl)-1 II-pyrazol-4-yl]-2-(1 -mcthylethyl)-2H-tetrazole; 5-[1 -(3-chlorophenyl)-1H-pyrazol-4-ylj-1-(1-methylethyl)-21-T-tetrazole; 5-[1 -(4-chlorophenyl)-1 i-1-pyrazol-4-ylj-2-(1-rnethylethyl)-2H-tetrazole; 5-[1 -(4-chlorophenyl)-1 H-pyrazol-4-yl]-1 -@ -methylethyl)-2H-tetrazole; 5-[1 -(2,3-diehlorophenyl)AH-pyrazol-4-yl]-2-(1-methylethyl)-2R-tetrazole; 5-[ 1 -(2,3-dichlorophenyl)-I 1-I-pyrazol-4-ylj-1 -(1 -methylethyl)-2H-tetrazolc; 5-[1 -(2,4-dichlorophenyl)-11 l-pyrazol-4-yl-2-( I -methylethyl)-21 1-teirazole; 5-[1 -(2,4-dichlorophenyl)-iIl-pyrazol-4-yfl-1-(1-mcthylethyl)-2H-tetrazole; 5-11 -(2,5-dichlorophenyl)-1H-pyrazol-4-ylJ-2-(l-methvlcthyl)-2H-tetrazole; 5-El -(2,5-dichlorophenyl)-1H-pyrazol-4-yI]-i-(1-methylethyl)-2H-tetrazolc; 5-[l-(2,6-dich1orophenyI)-lH-pyrazo1-4-yl-2-(1-methylcthy1)-2H-tetrazoJe; 5-[l -(2.6-dichlorophenyl)-1H-pyrazol-4-yl]-1 -(I -niethylethyl)-2f1-tetrazole; 5-[1 -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(I -rncthylcthyl)-2H-tetrazole; 5-[1 -(3,4-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -(1 -rnethylethyl)-211-tetrazole; 5-[1 -( .5-dichlorophenyl)-lI-I-pyrazol-4-yI]-2-(I -mcthylethyl)-2H-tetrazole; 5-[1 -(3,5 -dichiorophenyl)-I i-1-pyrazol-4-yl]-1 -@ -rnethylethyl)-2I I-tetrazole; 541 -(2-bromophenyl)-1H-pyrazol-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole; 5-[1 -(2-bromophenyl)-1 H-pyrazol-4-ylj-I -( -rncthylethyl)-2H-tetrazole; 5-[1 -(3 -bromophenyl)-1 H-pyrazol-4-yl] -2-( 1 -rnethylethyl)-2H-tetrazole; 5-[1 -(3-hromophenyl)-1 H-pyrazol-4-yl]-I -( -rnethylethyl)-2H-tetrazole; 5-[1-(4-bromophenyl)-1II-pyrazol-4-yl]-2-(1-rnethylethyl)-21-T-tetrazole; 5-[1 -(4-bromophenyl)-1 H-pyrazol-4-yfl-I -( -rnetliylethyl)-2H-tetrazole; 5-[1 -(4-fluorophenyl)-1II-pyrazol-4-yll-2-(1-rnethylethyl)-2H-tetrazole; 5-[ 1 -(4-fluorophenyl)-1H-pyrazol-4-yl] -1 -(1 -methylcthyl)-2H-tctrazolc; 5-[1-(2-fluorophenvl)-1fI-pyrazol-4-yl]-2-(1-methylethyl)-211-tetrazole; 5-[1 -(2-fluorophenyl)-1 H-pyrazol-4-yl]-i-(1 -rnethylethyl)-2!-I-tetrazole; 5-[1 -(2,3-cIiuiethyphcny1)-1 H-pyrazol-4-yl]-2-(1-rnethylethyl)-2H-tetrazole; 5-[1 -(2,3-dimethylphenyl)-1II-pyrazol-4-yl]-1-0 -methylethyl)-211-tetrazole; 5-[1 -(2,4-dimethyiphenyl)-1 H-pyrazol-4-yl]-2-( 1 -methylethyl)-2H-tetrazole; 5-[1 -(2,4-diniethyiphenyl)-1}-1-pyrazol-4-ylj-1 -@ -rnethylethyl)-2H-tetrazole; 5-[1 -(2,5-dimethyiphenyl)-I-T-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[1 -(2.5-dimethylphenyl)-IH-pvrazol-4-yl]-1-(l -rnethyleihyl)-2H-tetrazolle; 5-[l -(2.6-dirnethyiphenyl)-11-I-pyrazol-4-yl]-2-( 1 -methylethyl)-2H-tetrazole; 5-[1 -(2.6-dirnethyiphenyl)-1H-pyrazol-4-yl]-1 -(1 -mcthylethyl)-2H-tctrazole; 5-[I -(3.4-diniethylphenyl)-1 H-pyrazol-4-ylj-2-( 1-rnethylethyl)-21-I-tetraz&e; 5-[1 -(3,4-dimcthylphenyl)-1H-pyrazol-4-yl]-1 -(1-methylethyl)-2H-tetrazole; 5-fl -(3,S-dimethylphenyl)-1IT-pyrazol-4-yl]-2-( 1-methylethyl)-2H-tetrazole; 5-[1 -( ,5-dimethylphenyl)-I H-pyrazol-4-yl]-I -@ -rnethylethyl)-2H-tctrazole: 5-fl -(2-cthylphenyl)-1H-pyrazol-4-yl]-2-(l -methylethyl)-21-1-tetrazole; 5-11 -(2-ethyiphenyl)-1 I-1-pyrazol-4-yl]-1 -(1 -methylethyl)-2H-tetrazole; 5-f 1-(4-ethylphenyl)-1H-pyrazol-4-yi]-2-(l-methylethyl)-2H-tetrazole; 5-[i-(4-ethylphenyl)-1 H-pyrazol-4-yl]-1 -( -niethyethy-2H-tetrazoIe; 5-[ I -(4-methoxyphenyi)-I I-l-pyrazo!-4-y!] -2-(I -methylethyl)-211-tetrazole; 5-[1-(4-rnethoxypheny])-1H-pyrazol-4-yl]-l-(l-rnethylethyl)-2H-tetrazole; 2-0 -rnethylethyl)-5-f 1 -(2-metliylphenyl)-1II-pyrazol-4-yl]-211-tetrazole; 1-0 -methylethyl)-5-f 1 -(-rnethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-fl -methylethyl)-5-[I -(4-methylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -(1 -methylethyl)-5 -[1 -(4-methyiphenyl)-11 I-pyrazol-4-yl]-2F1-tetrazole; 5-(5-ciilloro-i-methyl-I H-pyrazo1-4-y-2-(I -methylethyl)-2H-tetrazo!e; 5-(5-chloro-1-methyl-IFI-pyrazol-4-yi)-1-(1-methyiethyi)-2H-tetrazole; 5-(5 -ehioro-1 -ethyl-H-pyrazol -4-yl)-2-(1 -rnethylethyl)-2H-tetrazole; 5-(5-ehloro-1-ethyl-1FI-pyrazol-4-yl)-1-(1 -rnethylethyl)-2H-tetrazole; 5-[5-ehioro-1 -(2-methyipropyl)-I H-pyrazol-4-ylj-2-( 1-methylethyl)-21-I-tetrazole; 5-[5-chloro-1 -(2-methyipropyl)-H-pyrazo]-4-yi]-1 -(1 -rncthylethyi)-2H-tetrazole; S 5-0 -benzyl-5-ehloro-1H-pyrazol-4-yl)-2-(1-methylethyl)-2H-tetrazole; 5-(1 -benzyl-5-ehloro-I H-pyrazol-4-yl)-1 -(I -rnethylethyl)-2}{-tetrazole; 5-(5-chloro-1-phenyl-1IJ-pyrazol-4-yl)-2-(1-methyletliyl)-211-tetrazole; 5-(5 -ehioro-1 -phenyl-11-I-pyrazol-4-yl)-1 -(1 -rnethylethyl)-2H-tctrazole; 5-[5-ehloro-1 4 -ehlorophenyl)-1H-pyrazol-4-yl]-2-( 1 -inethylethyl)-211-tetrazole; 5-[5-chloro-I -(2-ehiorophenyl)-1 H-pyrazol-4-ylj-l -@ -methylethyl)-2H-tetrazole; 5-[5-chloro-1-(3-ehlorophcnyl)-1H-pyrazo[-4-yI]-2-(1 -methylethyi)-2H-tetrazole; 5-[5-chloro-1 -(3-ehlorophenyl)-1II-pyrazol-4-yl]-1 -(1 -rnethylethyl)-2H-tetrazole; 5-[5-chloro-1 -(4-ehlorophenyl)-1H-pyrazol-4-yl]-2-(1 -metliylethyl)-211-tetrazole; 5-{5-chloro-1-(4-ehlorophenyl)-1}-l-pyrazol-4-yl]-1 -o -methylethyl)-2H-tetrazole; 5-[5-chloro-1 -(,3-dicffloropheny1)-1H-pyrazo1-4-y1]-2-(1-rncthylethy)-2H-tetrazoIe; 5-{5-chloro-1-(2,3-dicfflorophenyl)-1 H-pyrazol-4-yl]-1 -(1-methylethyl)-2F1-tetrazole; 5-[5-chloro-1 -(2,4-dichlorophenyl)-1 H-pyrazol-4-yl]-2-(1 -rnethyletllyl)-2H-tetTazole; 5-[5-chloro-1 -(2.4-dichloropheny-1H-pyrazoh4-yfl-1 -(1 -methylethyl)-21T-tetrazole; 5-[5-chIoro-i-(2,5-dich]oropheny1)-1H-pyrazo1-4-yl-2-(1-methylethyI) -2H-tetrazo1e; 5-[5-chloro-1-(2.5-dichlorophenyl)-1 iI-pyrazol-4-yll-1 -(1 -rnethylethyl)-211-tetrazole; 5-[5-chloro-1-(2.6-dichlorophenyl)-1 H-pyrazo1-4-yl-2-(1-rnethylethy1)-2H-terazole; 5-[5-ehloro-1 -(2.6-diehlorophcnyl)-1 I-1-pyrazol-4-ylj-1 -(1-methylethyl)-2H-tetrazole; 5-[5-chloro-1 -(3,4-dichIorophenyI)-1-1-pyrazo!-4-y!-2-(1 -methylethy[)-2H-tetrazole; 5-[5-ehloro-1-(3.4-dichlorophenyl)-1 H-pyrazol-4-y]j-1-0 -rnethylethyl)-2H-tetrazole; 5-[5-chloro-1-(3.5-dichlorophenyl)-1I-I-pyrazol-4-ylj-2-(1-rnethylethyl) -211-tetrazole; 5-[5-chloro-1 -(3,3-dichlorophenyl)-1 H-pyrazol-4-yI]-1 -o -methylethyl)-2H-tetra7ole; 5-[1 -(2-bromophenyl)-5-chloro-1H-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 541 -(2-bromophenyl)-5-chloro-1H-pyrazol-4-yll-1 -(1-methylethyl)-211-tetrazole; 5-[1 -(3-brornophenyl)-5-ehloro-1H-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tctrazole; 541 -(3-bromophenyl)-5-ehloro-1H-pyrazol-4-yl]-i-(1-rnethylethyl) -2H-tetrazole; 5-[1 -(4-bromophenyl)-5-chloro-1 H-pvrazol-4-yl]-2-(1-methylethyl)-2H-tetrazole; 541 -(4-bromophenyl)-5-chloro-1H-pyrazol-4-yl]-1-(1-methylethyl) -211-tetrazole; 5-[5-ehloro-1 -(4-fiuorophenyl)-TH-pyrazol-4-yl]-2-(t-nwthylethyl)-2H-tetrazole; 5-j5-ehloro-1 -(4-fluorophenyl)-11-I-pyrazol-4-yl]-1-( 1-methykthyl)-211-tetrazole; 5-[5-chloro-1 -(2-fluorophenyl)-1 H-pyrazol-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole; 5-[5-chloro--(2-fluorophenyl)-11-1-pyrazol-4-yl]-1 -(1 -rnethylethyl)-211-tetraz5le; 5-[5-ehloro-1-(2,3-dimethylphenyl)-IH-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[5-ehloro-I -(2,3-clirnethylphenyl)-1 H-pyrazol-4-yl]-1-(1 -methylcthyl)-211-tctrazole; 5-[5-ehloro-1 -(2, 4-dirnethylphcnyl)-1 T-1-pyrazol-4-yl]-2-( -rnethylethyl)-2H-tetrazole; 5-[5-ehloro--(2, 4-dimethylphenyl)-IH-pyrazol-4-yl]-1-(1-rncthylcthyl)-2H-tetrazole; 5-[5-ehloro-1 -(2,5-dirncthylphenyl)-1 H-pyrazol-4-ylj-2-( 1 -methylethyl)-211-tetrazole; 5-[5-chloro-1 -(2,5-dirnethylpheriyl)-1 H-pyrazol-4-yl]-1-0 -methylethyl)-2H-tetrazole; 5-[5-ehloro-1 -(2,6-dirnethylphenyl)-1 H-pyrazol-4-ylj-2-( 1 -rnethylethyl)-211-tetrazole; 545-ehloro-1-(2,6-dimethylphenyl)-1H-pyrazol-4-yl]-1-(1 -methylethyl)-2H-tetrazole; 5-[5-chloro-1 -(3,4-dirnethylphenyl)-1II-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tctrazole; 5-[S-chloro-1 -(3,4-dimcthylphenyl)-1H-pyrazol-4-ylj-1-(1-methylethyl)-211-tetrazole; 5-[5-chloro-1-(3,5-dimethylphenyl)-1H-pyrazol-4-yl]-2-(1 -methyletliyl)-2H-tetrazole; 5-[5-ehloro-1 -(3.5-dimethylphenyl)-1 FT-pyrazol-4-yl]-1-0 -methylethyl)-2H-tetrazole; 5-[5-eh]oro-1 -(2-ethyiphenyl)-1 H-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[5-ehloro-1-(2-ethylphenyl)-IH-pyrazol-4-yI]-1 -(1 -methylethyl)-2H-tetrazole; 5-[5-ehloro-1-(4-ethylphenyl)-1H-pyrazol-4-ylj-2-(1-methylethyl) -2H-tctrazole; S-[5-chloro-1 -(4-ethylphenyl)-1H-pyrazol-4-yI]-1 -(1 -rnethylethyl)-21T-tetrazole; 5-[5-ehloro-1-(4-niethoxyphenyl)-1 II-pvrazol-4-ylI-2-(1 -mcthylethyl)-2H-tetrazo!e; 5-[5-ehloro-1 -(4-methoxyphenyl)-1 H-pyrazol-4-ylj-i-(1-rnethylethyl)-211-tetrazole; 5-[5-ehloro-1-(2-methylphcnyl)-1H-pyrazo!-4-yI]-2-(1 -methylethyl)-2H-tetrazole; 5-[5-chioro-1 -(2-methyiphenyl)-11 I-pyrazol-4-yl]-1 -(1 -methylethyl)-2H-tetrazole; 5-[5-ehloro-1 -(4-rnetbylphenyl)-1H-pyrazol-4-yfl-2-(1-methylethyl)-2H-tetrazole; 5-[5-ch1oro-1-(4-methy1pheny)-1H-pyrazo!-4-yI]-1 -Li -methylethyl)-2H-teirazole; 5-(5-brorno-I-methyl-lI I-pyrazol-4-yT)-2-(1 -methyl ethyi)-2H-tetrazole; 5-(5-bromo-I -methyl--1 H-pyrazol-4-yl)-1 -(1 -rnethylethyl)-21 1-tetrazole; 5-(5-bromo-I -ethyL 1 H-pyrazol-4-yl)-2-(l -rnethylethyl)-2H-tetrazole; 5-(-bromo-1-ethy1-1II-pyrazo1-4-y1)-1 -(1 -methylethyl)-2H-tetrazole; 5-[5-hromo-I -(2-methyipropyl)-I H-pyrazol-4-yl]-2-( -mcli ylelhyl)-2H-tetrazole; 5-[5-brorno-1 -(2-methylpropyl)-1I-I-pyrazol-4-yfld -0 -methyIethy-2H-tetrazole; I -benzyl-5-bromo-l H-pyrazol-4-yl)-2-(l-methylethyl)-2H-tetrazole; 5-0 -benzyl-5-bromo-1H-pyrazol-4-yl)-1-(1 -methylethyl)-2H-tetrazole; 5-(5-brorno-1 -phenyl-11-I-pyrazol-4-yl)-2-( -methylethyl)-2H-tetrazole; 5-(5-bromo-1 -phenyl-1 H-pyrazol-4-yl)-I -( I -methylethy])-2H-tetrazole; 5-[5-bromo-1 -(2-chlorophenyl)-1 H-pyrazol-4-yl]-2-(1 -mcthylethyl)-2H-tetrazole; 5-[5-brorno-1 -(2-chlorophenyl)-1 H-pyrazol-4-yl]-1-<1 -methylethyl)-2F1-tetrazole; 5-[5-bromo-1 -(3-chlorophenyl)-1 H-pyrazol-4-yI]-2-(1 -mcthylethyl)-2H-tetrazolc; 5-[5-bromo-1-(3-chlorophenyl)-IH-pyrazol-4-yl]-1-(1-rnethylethyl) -21i-tetrazole; S 5-[5-bromo-1 -(4-chiorophenyl)-] H-pyrazo]-4-yij-2-(1-nictbylethyl)-2H-tctrazole; 5-[5-bromo-1-(4-chlorophenyl)-1II-pyrazol-4-yll-1-(1-mcthylethyl) -2H-tetrazole; 5-[5-brorno--(2,3-dic]ilorophenyl)-1H-pyrazol-4-yll-2-(1-rnethylethyl) -211-tetrazole; 5-[5-brorno-1-(2.3-dichlorophenyl)-1H-pyrazol-4-yl]-1-(1-methylethyl) -211-tetrazole; 5-[5-brorno-1-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(1-methylethyl) -211-tetrazole; 5-[5-brorno-1-(2,4-dichlorophcnyl)-IH-pyrazol-4-yl]-1 -u -rnethylethyl)-2H-tetrazole; 5-[5 -bromo-I -(2,5-dichiorophenyl)-1 H-pyrazol-4-yl] -2-( 1 -methylcthyl)-21-1-tctrazolc; 5-[5-brorno-I -(2,5-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -(1 -methylethyl)-211-tetrazole; 5-[5-bromo-I -(2,6-dichjorophenvl)-1 H-pyrazol-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole; 5-[5-bromo-1 -(2,6-diehIoropheny-H-pyrazol-4-yi]-1 -(1-rnethylethyl)-2H-tetrazole; 5-[5-bromo-1-(3,4-dichlorophenyl)-11-1-pyrazol-4-ylJ-2-(1-methylethyl) -2H-tetrazole; 5-[5-bromo-1 -(3,4-dichlorophenyl)-IH-pyrazol-4-ylJ-1 -(1-rnethylethyl)-2H-telrazole; 5-[5-bromo-I-(3.5-dichlorophenyl)-I 1-1-pyrazol-4-ylJ-2-(1 -rnethylcthyl)-2H-tctrazole; 5-[5-bromo-1 -(3.5-dichloropheny])-l1-T-pyrazol-4-yl]-1 -(1-rnethylethyl)-21-I-tetrazolc; 5-[5-bromo-1-(2-bromophcnyl)-1 H-pyrazol-4-yI]-2-(I -methylethyl)-2H-tetrazole; 5-[5-bromo-1 -(2-bromophenyl)-1 II-pyrazol-4-yl]-1-0 -methylethyl)-2H-telrazole; 545-bromo-1 -(3-bromophenyl)-1 H-pyrazol-4-yl]-2-(1 -methylethyl)-211-tetrazole; 5-[5-brorno-1-(-brornopheny1)-1 H-pyrazol-4-yl]-1 -u -rnethylethyl)-21-1-tetrazole; 5-[5-bromo-1 -(4-bromophenyl)-1 H-pyrazol-4-ylJ-2-( 1 -rncthylcthyl)-2H-tctrazolc; 5-[5-brorno-I -(4-bromophenyl)-1 1-1-pyrazol-4-ylj.-1 -(1-rnethylethyl)-21-1-tetrazole; 5-{5-brorno-1 -(4-fluoroplienyl)-1 H-pyrazol-4-yl]-2-(1-niethylethyl)-2H-letrazole; 5-[5-hromo-1 -(4-fluorophenyl)-I H-pyrazol-4-yI]-1-(1-methylethyl)-2H-tetrazole; 5-15-bromo-1-(2-tluorophenyl)-IH-pyrazol-4-yI]-2-O -methyIethy-2H-tctrazok; 5-[5-brorno-1 -( -fluorophenyl)-IH-pyrazol-4-yl]-1-0 -methylethyl)-2H-tetrazole; 5-[5-bromo.-1 -(2,3-dimethylphenyl)-1II-pyrazol-4-yli-2-(1 -methylethyl)-2H-tetrazole; 5-[5-bromo-I -(2,3-dimcthylphenyl)-1H-pyrazoL-4-ylj-1-(1 -methyleihyl)-2H-tetrazole; 5-15-bromo-1-(2,4-dimethylphenyD-1H-pyrazol-4-yII-2-O -mcthylcthyl)-2H-tctrazolc; 5-[5-brorno-1-(2,4-dimethylphenyl)-1H-pyrazol-4-ylj-1-(1 -methylethyl)-2H-tetr'azole; 5-13-bromo-1-(2,5-dimethylphenyD-1 I-1-pyrazol-4-yI]-2-(1 -rnet]iylethy])-2H-tetrazole; 5-[5-brorno-1-(2,5-dirnethylphenyl)-1II-pyrazol-4-yl]-1-(1-rnethylcthyl) -2H-tctrazolc; 5-[5-hromo-] -(2,6-dimethylphenyl)-1H-pyrazoh4-yl]-2-(1 -methyethyI)-2H-tetrazo1e; 5-[5-bromo-1-(2,6-dirnethylphenyl)-1 H-pyrazol-4-yLj-l -( I -methyIethy-2H-tetrazo1e; 5-[5-bromo-1 -(3,4-diniethylphenyl)-1H-pyrazol-4-yl]-2-(1-methylethyl)-2H-tetrazole; 5-[5-bromo-1 -(3,4-dimethylphenyl)-1 H-pyrazo1-4-y1]--(i -rnethylethyl)-2H-tetrazole; 5-[5-brorno-1 -(3,5-dirnethylphenyl)-1H-pyrazol-4-yl]-2-(1-rnethykthyl)-211-tctrazole; 5-[5-bromo-1 -(3,5-dimethy!pheny)-I H-pi'azok4-y1j-1-( 1-niethylethyl)-2H-tetrazole; 5-[5-brorno-1 -(2-ethypheny1)-1II-pyrazo1-4-y1]-2-(1-methykthy1)-2H-tctrazo1e; 5-[5-bromo-1 -(2-ethylphenyl)-11-1-pyrazol-4-ylj-1-( 1 -rnethylethyl)-2H-tetrazole; 5-[5-brorno-1 -(4-ethypheny1)-1II-pyrazol-4-yl]-2-(1-mcthylethyl)-2H-tctrazole; 3-[5-brorno-1 -(4-ethylphenyl)-I H-pyrazol-4-ylj-1-(1-rnethylethyl)-21-I-tetrazole; 5-[5-bromo-1-(4-methoxyphenyl)-1I-1-pyrazol-4-yI]-2-(1 -rnethy1ethy1)-2H-tetrazoe; 5-[5-brorno-1-(4-methoxyphenyl)-1Ii-pyrazol-4-yI]-1 -(1 -methyIethy)-2H-tetrazoe; 5-[5-brorno-1 -(2-methylphenyl)-1 H-pyrazol-4-yli-2-(1-methylethyl)-211-tetrazole; 5-[5-bromo-I -(2-methyphcny1)-1 H-pyrazol-4-ylj-I-(1-rnethylethyl)-21T1-tetrazole; 5-[5-bromo-1-(4-methy1pheny1)-1EJ-pyrazo1-4-yl-2-(1 -methy1ethy-2H-tetrazoIe; 5-[5-bromo-1 -(4-methylphenyl)-1 H-pyrazo1-4-y1-1 -o -methylethyl)-2H-tetrazole; 5-(5-iodo-1 -methyl-I H-pyrazol-4-yl)-2-(1 -methy]cthyl)-2H-teuazole; 5-(5-iodo-1 -methyl-1 I-1-pyrazol-4-yl)-1-(1 -mcthylcthyl)-211-tetrazole; 5-@ -ethyl-5-iodo-I H-pyrazoI-4-y)-2-(1 -methylethy)-2H-tetrazoIe; 5-(1-ethyl-5-iodo-1II-pyrazol-4-yl)-1-(1-rnethylethyl)-2H-tetrazole; 545-iodo-1-(2-methylpropyl)-1 H-pyrazol-4-yl]-2-(1-methylethyl)-21I-tetrazole; 5-[5-iodo-1-(2-rnethylpropyl)-1 H-pyrazol-4-yl]-I -(1 -methylethyl)-2H-tetrazole; 5-(1-benzyl-5-iodo-1H-pyrazol-4-yl)-2-(1-methylethyl)-2JiI-tetrazole; 5-(1-benzy]-5-iodo-IH-pyrazol-4-yl)-1-(1-methylethyl)-211-tetrazole; 5-(5-iodo-l -phenyl-1 H-pyrazol-4-yl)-2-(I -methylethyl)-21-1-telrazole; 5-(5-iodo-1 -phenykl H-pyrazo-4-yI)-1 -( -rnethylcthyl)-2T-T-tctrazole; 5-[1 -(2-chlorophenyl)-5-iodo-1iI-pyrazo!-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[1 -(2-ehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1 -(1 -meihylethyl)-2H-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-1I-I-pyrazol-4-yfl-2-(1 -methylethyl)-211-tetrazole; 5-[1 -(3-ehlorophcnyi)-5-iodo-i H-pyrazoh4y1j--1-(1-rnethy1ethy1)-2H1etrazo1e; 5-[1 -(4-chlorophenyl)-5-iodo-11-1-pyrazol-4-yl]-2-( I -methylethyl)-2H-tetrazole; 5-[l -(4-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-(1-methylethyl)-2H-tetrazole; 5-[1 -(2,3-dichbrophcny1)-5-iodo-1H-pyrazol-4-yI-2-(T-methy!ethy1) -2H-tetrazo1e; 5-[1 -(2,3-dich1oropheny1)-5-iodo-1II-pyrazo1-4-y1-1-(1-rnethy1ethy1) -2H-tetrazo1e; 5-[] -(2,4-diehlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2-(I -methylethy)-2H-tetrazo1e; 5-[1 -(2.4-dich!orophenvl)-5-iodo-IH-pyrazol-4-yl]-1-(1-methylethyl) -211-tctrazolc; 5-[1 -(2,5-dichlorophenyl)-5-iodo-1iI-pyrazol-4-yl]-2-(1 -methylethy)-2H-tetraz&e; 5-[1 -(25-dich!orophenyl)-5-iodo-1II-pyrazol-4-yl]-l-(1-methylethyl) -2H-tetrazolc; 5-[l -(2,6-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(1 -rnethyiethyi)-2H-tetrazole; 5-11 -(2,6-dichiorophenyl)-5-iodo-1II-pyrazol-4-yl]-1-(1-inethylethyl) -2H-tetrazolc; 5-11 -(3,4-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(1 -niethylethyl)-2H-tetrazole; 5-11 -(2,6-dich1orophcny)-5-iodo-I H-pyrazol-4-yl]-l-(1-methylethyl)-211-tetrazole; 5-11 -(3,5-dichlorophenyl)-5-iodo-IH-pyrazol-4-yi]-2-(1 -methylethyl)-2H-tetrazole; 5-[i -(3,5-dichlorophenyl)-5-iodo-1II-pyrazoi-4-vl]-1 -(1 -methylethyl)-2H-tetrazole; 5-[ I -(2-bromophenyl)-5-iodo-1 l-l-pyrazol-4-yfl-2-(1 -methylethyi)-21-l-tetrazole; 5-11 -(2-hromophenyl)-5-iodo-FI-pyrazol-4-yl]-l -(1 -rnethylethyl)-2H-tetrazok; 5-11 -(3-brornophenyl)-5-ioclo-I 1-1-pyrazo!-4-yl]-2-(J -methylethyl)-2H-tetrazole; 5-{ 1 -(3-brornophenyl)-5-iodo-1 H-pyrazol-4-yl]-l -u -methylethyl)-211-tetrazole; 5-[1 -(4-bromophenyl)-5-iodo-1 H-pyrazol-4-yl]-2-(1 -rnethylethyl)-2H-tetrazole; 5-[1-(4-bromopheny1)-5-iodo-1II-pyrazo1-4-y1]--(1 -methylcthyi)-2H-tetrazolc; 5-[1-(4-fluoropheny1)-5-iodo-1H-pyrazo1-4-y1]-2-(l-mcthy1cthy) -2I1-tetrazo1e; 5-[1-(4-fluorophenyl)-S1odo-1H-pyrazol-4-yfl-I -(1 -rnethylethyl)-21-l-tetrazole; 5-[I -(2-fluoroplienyl)-5-iodo-1iI-pyrazol-4-yl]-2-(1 -methylethyl)-2H-tetrazole; 5-[1-(2-fluorophcnyl)-5-iodo-IH-pyrazol-4-yl]-i -o -methyIethyl)-2H-letrazole; 5-11 -(2,3-dimethylphenyl)-5-iodo-1H-pvrazol-4-yl]-2-(1-methylethyl) -2H-tetrazole; 5-[1 -(2,3-dimethylphenyl)-5-iodo-1 II-pyrazol-4-yl]-l-(1 -methy1ethy1)-2H-tetrazoe; 5-11 -(2,4-dimethylphenyl)-5-iodo-IH-pyrazol-4-ylj-2-(l-methylethyl) -211-tetrazole; 5-il -(2,4-dimethylphenyl)-5-iodo-1 H-pyrazol-4-yI]-I -(1-methylethyl)-2H-tetrazole; 5-l1-(2,5-dimethy1pheny-5-iodo-1Ii-pyrazo1-4-yq-2-Q -methylethyl)-2H-tetrazolc; 5-il -(2,5-dimetliylphenyl)-5-iodo-1H-pvrazol-4-yl]-1 -u -methy1ethyI)-2H-tetrazoe; 5-li -(2.6-dimethylphenyl)-5-iodo-1H-pvrazol-4-yl]-2-(l-methylethyl) -2H-tetrazole; 5-ll-(2,6-dimethylphenyl)-5-iodo-1II-pyrazol-4-yl]-1-(1 -methylethyl)-2H-tetrazole; 5-11 -(3,4-dimethyiphenyl)-5-iodo-I H-pyrazol-4-ylJ-2-(l-rnethylethyl)-2H-tetraz5le; 5-l1-(3,4-dirnethylphenyl)-5-iodo-lIT-pyrazol-4-yll-1-(l-mcthylethyl) -211-tetrazole; 5-li -(3,5-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-(l-meihylethyl) -211-tetrazole; 5-li -(3,5-dimethylphenyl)-5-iodo-l H-pyrazol-4-yll-1 -o -rnethylethyl)-2H-tetrazole; 5-il -(2-ethylphenyl)-5-iodo-IH-pyrazol-4-yl]-2-(l -rnethylethyl)-21I-tetrazole; 5-[l -(2-cthylphenyl)-5-iodo-IH-pyrazol-4-yI]-1 -o -rnethylethyl)-2H-tetrazole; 5-fl -(4-ethylphenyl)-5-iodo-IH-pyrazol-4-yIj-2-(1-methylethyl)-2H-tetrazole; 5-[1 -(4-cthy1pheny)-5-iodo-1Ihpyrazo1-4-y1]-I -(I -rnethylethyl)-2H-tetrazole; 5-[5-iodo-I -(4-methoxypheny-H-pyrazol-4-ylj-2-(1-methylethyl)-2H-tetrazole; 5-[5-ioclo-1 -(4-rnethoxyphenyl)-1II-pyrazo!-4-yIj-1 -(1-rnethylethyl)-211-tetrazole; 5-[5-iodo-1-(2-inethylphenyt)-1 H-pyrazol-4-yl]-2-(i-methylethyl)-2H-tetrazole; 5-[5-iodo-i-(2-rnethylphenyl)-1FI-pyrazol-4-ylj-1-(1 -rnethylethyl)-211-tetrazole; 5-[5-iodo-1-(4-methylphcnyl)-1H-pyrazol-4-yl]-2-(i -methylethy])-2H-telrazole; 5-[5-iodo-1 -(4-rnethylphenyl)-1II-pyrazol-4-yfl-1 -c -methylethyl)-2H-tetrazole; 2-benzyI-5-(1-methyl-H-pyrazol-4-yl)-2H-tetrazole; 1 -benzyi-5-(1 -methyl-i I-I-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5 -O -ethyl-i I-1-pyrazol-4.-yl)-2H-tetrazole; 1-benzyl-5-(i-cthyl-IH-pyrazol-4-yl)-211-tetrazole; 2-benzyl-5 -[1 -(2-methylpropyl)-I H-pyrazol-4-yli-2H-tetrazolc; I -benzyl-5 -[ J -(2-methyipropyl)-1 H-pyrazol-4-yl]-21-I-tetrazole; 2-benzy1-5-(i-henzy-] H-pyrazoi-4-yl)-2H-tetraz&e; -benzyl-5-(1 -benzyl-1 H-pyrazol-4-yI)-2H-tetrazole; 2-benzy!-5-( I -phenyl-1 II-pyrazol -4-yl)-2H-tetrazole; 1 -benzyl-5-( I -phenyl-I T-l-pyrazol-4-yl)-2H-tetrazo le; 2-benzyl-5 -[1 -(2-chlorophenyi)-I II-pyrazol-4-ylj -2H-tetrazole; 1-benzyl-5-[1 -(-ehlorophenyi)-1H-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[i -(3-chiorophenyl)-il-Lpyra2ol-4-yl]-211-tetrazo!e; I -benzvl-5-[i-(3-chlorophenyl)-lI-T-pvrazol-4-ylj-2H-tetrazole; 2-henzyl -5-[ -(4-chlorophenyi)-1 H-pyrazol-4-yI]-2 H -tetrazole; 1 -benzyl-5-{ 1 -(4-chlorophenyl)-1!-i-pyrazol-4-yl]-2H-tetrazoic; 2-benzyi-5-[1-(2,3-dichlorophenyl)-1 H-pyrazoi-4-yi-2II-tetrazoie; I -benzyl-5-[ I -(2,3-dichlorophenyl)-1H-pyrazol-4-yI]-2H-tetrazoie; 2-bcnzyl-5-[I -(2,4-diehlorophenyl)-1 iI-pyrazol-4-yl]-2H-tetrazole; i-benzyi-5-[1-(2,4-diehlorophenyl)-I H-pyrazol-4-ylJ-211-tetrazole; 2-benzyl-5-[i -(2,5-dichlorophenyl)-iFI-pyrazol-4-yI]-2H-tctrazo!e; 1 -benzyl-5-[1-(2,5-dichlorophenyl)-1 H-pyrazol-4-ylj-2H-tetrazole; 2-hcnzyl-5-[i-(2,6-dichlorophenyi)-1II-pyrazol-4-yI]-21-T-tetrazole; l-benzyl-5-[1 -(2,6-dichiorophenyl)-I H-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[i -(3.4-dichlorophenyl)-If1-pyrazol-4-yij-2H-tetra2ole; 1 -benzyl-5-[ 1 -@ ,4-dichlorophenyl)-1 H-pyrazoi-4-yi] -21-1-tetrazole; 2-beiy1--[1 -(3,5-dichlorophenyl)-i H-pyrazol-4-yl]-2H-tctrazole; I -benzyl-5-[I -@ ,5-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[I -(2-bromophenyl)-I H-pyrazot-4-yl]-2H-tetrazole; I -benzyl-5-[I -(2-brornophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzy!-5-[I-(3-brornophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[I -(4-bromophenyl)-1 H-pyrazol-4-yl] -2H-tetrazolc; I -benzyl-5-[ 1 -(4-bromophenyl)-1H-pyrazol-4-yl]-2F1-tetrazole; 2-benzvl-5-[1 -(4--fluorophenyl)-I II-pyrazol-4-yl]-2H-tetrazole; I -benzyl-5-[ I -(4-fluorophenyl)-I H-pyrazol-4-ylj-2H-tetrazole; 2-henzyl-5-[1 -(2-fluorophenyl)-I H-pyrazol-4-yI]-2H-tctrazole; 1 -benzyl-5-{1 -(2-fluorophenyl)-I II-pyrazol-4-yI] -214-tetrazole; 2-benzyl-5-[1 -(2,3 -dimelhyiphenyl)-1 H-pyrazol-4-yl] -2H-tetrazole; 1 -benzyl-5-[1 -(2,3 -dimethyiphenyl)-1 H-pyrazol-4-yl] -2H-telrazole; 2-benzyl-5-[1 -(2,4-dirnethylphenyl)-1 iI-pyrazol-4-yfl -21-1-tetrazole; 1-benzyl-5-[1-(2,4-dirnethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-henzyl-5-[1 -(2,5-dimethyiphenyl)-114-pyrazol-4-yI]-2H-tetrazo!e; 1 -benzyl-5-[1 -(2,5-dirnethylphenyl)-1I-I-pyrazol-4-yl]-21T-tetrazolc; 2-henzyl-5-[1 -(2,6-dimethylphenyl)-I H-pyrazol -4-yl] -2H-tetrazole; 1 -benzyl-5-{1 -(2,6-dimethylphenyl)-114-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[1 -(3.4-dimethyiphenyl)-IH-pyrazol-4-ylj-2H-tetrazole; I -benzyl-5-[I -(3,4-dimethylphenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 2-benzyl-5 -[1 -(3,5 -climethyiphenyl)-I H-pyrazol-4-ylJ-21-I-tetrazole; 1 -benzyl-5 -[1 -(3,5 -dimethyiphenyl)-1 H-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5 -[1 -(2-ethylphenyl)-II-1-pyrazol-4-yI] -2H-tetrazole; 1-benzyl-5-[1-(2-ethylphenyl)-IH-p'Tazo1-4-y1]-2H-tetrazolc; 2-henzyl-5-[1 -(4-ethyiphenyl)-1II-pyrazol-4-yl]-211-tetrazole; I -benzyl-5-[1 -(4-ethyiphenyl)-1H-pyrazol-4-yl] -2H-terazole; 2-henzyl-5-[l -(4-methoxyphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; I -benzyl-5-[I -(4-methoxyphenyl)-1H-pyrazol-4-ylJ-2H-tetruzole; 2-henzyl-5-[I -(2-methylphcnyl)-I II-pyrazol-4-yl]-21 I-tctrazolc; 1 -benzyl-5-[I -(2-methyiphenyl)-I II-pyrazol-4-yl]-21 1-tetrazole; 2-benzyl-5-[I -(4-rnethylphenyl)-1H-pyrazol-4-yI]-2F1-tetrazole; 1 -bcnzyl-5-[l -(4-methyiphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-(5-ehloro-1 -methyl-i I-I-pyrazol-4-yI)-2H-tetrazole; 1-benzyl-5-(5-chloro-1 -rncthyl-IH-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-(5-chloro-1-ethyhlII-pyrazol-4-yI)-2H-tetrazole; 1 -benzyl-5-(5-chloro-1-ethyl-I H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-[5-chloro-1 -(2-methylpropyl)-1 I-T-pyrazoh4-yl]-21-1-tetrazole; 1benzy1-5-[5-ehIoro-I-(2-rnethy1propy1)-1H-pyrazo1-4-y1]-2II-tetrazo1e; 2-benzyh5-(1-benzyl-5-chloro-I T-!-pyrazol-4-yl)-2H-tetrazole; 1-benzyl-5-(I -benzyl-5-thloro-1H-pvrazol-4-yl)-21-I-tetrazo!e; 2-benzyl-5-(5-ehJoro-1-phenyl-1II-pyrazol-4-yl)-2H-teirazole; 1-benzyl-5--(5-ehloro-1-phenyl-1JI-pyrazol-4-yl)-2H-tetrazole; 2-benzv1-5-[5-cffloro-1-(2-chloropheny1)-11-I-pyra. zo1-4-v1-2J-J-tetrazo1e; 1-benzy1-5-[5-choro-1-(2-ch1orophenyI)-I FI-pyrazol-4-ylI-211-tetrazole; 2-benzyl-5-[5-ehloro-1-(3-chlorophenyl)-1H-pyrazol-4-y!]-2H-tetrazole; 1 -benzyl-5-[5-ehloro-i -(3-chlorophenyl)-1 iI-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-ehloro-1-(4-ehlorophenyl)-l H-pyrazol-4-ylj-211-tetrazole; 1-benzyl-5-[5-c.hloro-1-(4-chlorophenyl)-l H-pyrazol-4-yl]-21-I-tetrazole; 2-henzyl-5-[5-ehloro-I-(23-dielilorophenvl)-1II-pyrazol-4-vI] -2H-tetrazole; 1-benzy1-5-[5-chIoro--(23-diehlorophenyl)-IH-pyrazol-4-yl]-211-tetrazole; 2-henzyl--5-[5-ehloro-i-(2,4-dichJorophenyl)-1H-pyrazol-4-yl I-2H-tetrazole; 1-benzy1-5-[5-eh!oro--(24-diehIoropheny1)1H-pyra'zo1-4-y1]-2H-tetrazo1e; 2-benzyl-5-[5-c.hloro-1-(2,5-dichlorophenyl)-IH-pyrazol-4-yl] -2H-tetrazole; I -henzyl-5-[5-chloro-1-(2,5-diehlorophenyl)-1II-pyrazol-4-yl] -21-!-tetrazole; 2-benzyl-5-[5-ehloro-1-(2,6 -dichlorophenyl)-IH-pyrazol-4-yl]-2h4etrazolc; I-benzyl-5-[5-chloro-1-(2,6 -dichlorophenyl)-l H-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[5-chloro-1-(3,4-dichlorophenyl)-1H-pyrazol-4-yI]-2H-telrazole; 1 -henzyl-5-[5-ehloro-1-(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-chloro-I -(3,5-dichIoropheny1)-1H-pyrazo1-4-y1-2H-tetrazo1e; I -benzyl-5-[5-chloro-1-(3,5-diehlorophenyl)-1 H-pyrazol-4-yI]-21-I-tetrazole; 2-benzyl-5 -[1 -(2-brornophenyl)-5 -chioro-11 I-pyrazol-4-yfl -2T-J-tetrazol e; I-benzyl-5-[1-(2-broinophenyl)-5-chloro-l H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[l -(3-hromophenyl)-5-chloro-1I-I-pyrazol-4-yI]-21-1-tetrazole; I-benzyl-5-{1 -(3-hromophenyl)-5-ehloro-IH-pyrazol-4-yl]-2H-tetrazole; 2-benzyI-5-[1-(4-brornopheny1)-5-ch1oro-1II-pyrazo1-4-yl-2H-tetrazo1e; 1-benzy1-5-[1--(4-hromophenyI)-5-ch1oro-1H-pyrazo1-4-y1-2II-tetrazole; 2-benzyl-5-[5 -ehioro-1 -(4-fluorophenyl)-I H-pyrazol-4-ylj-2H-tetrazole; -henzy1-5-5-ch1oro-1 -(4-fluorophenyl)-1 H-pyrazol-4-yIj-2H-tetraz6le; 2-benzyl-5-[5-chloro-1 -(-t1uoropheny1)-1H-pyrazo1-4-yfl-2II4etrazole; 1 -benzyl-5-[5-chloro-1-(2-fluorophenyl)-1 H-pyrazol-4-ylj-2H4etraz6le; 2-benzyl-5-[5-chloro-1 -(2.3-dirnethyiphenyl)-1H-pyrazol-4-yfl-2H-tetrazole; I -henzyl-5-[5-chloro-1-(2,3-dirnethylphenyl)-I fl-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-chloro-1 -(2,4-dirnethylphenyl)-1H-pyrazok4-yl]-21-1-tetrazole; 1 -benzyl-5-[5-chloro-1-(2,4-dimcthylphenyl)-1 I-T-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[5-chloro-1-(2.5-dirnethylphenyl)-1II-pyrazol-4-vl] -2H-tctrazole; 1-benzyl-5-[5-chloro-1-(2,5-dimethylphenyl)-1 H-pyrazol-4-yfl-211-tetrazole; 2-henzyl-5-[5-chloro-1-(2.6-dimethylphenyl)-1H-pyrazol-4-yfl-2H-tetrazole; 1-bcnzyl-5-[5-chloro-I -(2,6-dirnethylphenyl)-1II-pyrazol-4-yfl-2H-totrazole; 2-benzyl-5-[5-chloro-1-(3,4-dimethylphenyl)-H-pyrazol-4-ylj-2H-tetrazole; I -benzyI-5-5-ch1oro-1-(3,4-dimethylphenyl)-1 1-1-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[5-chloro-1 -@ .5-dirnethyiphenyl)-1 1-1-pyrazol-4-yfl-2H-tetrazo!e; 1-benzyl-5-[5-chloro-T -(3,5-dirnethylphenyl)-IH-pyrazol-4-yl]-21-I-tetrazole; 2-benzyl-5-[5-ehloro-1-(2-ethylphenyl)-11-1-pyrazol-4-yl]-2H-tctrazole; I -benzy]-5-5-ch1oro-1-(2-ethy1pheny1)-1H-pyrazo1-4-y1]-2II-tetrazo!e; 2-benzyl-5-[5-ehloro-I -(4-ethyiphenyl)-11-1-pyrazo1-4-y1-2H-tetrazo1e; I -henzyl-5 -[5-ehloro-1 -(4-ethyiphenyl)-1 I-1-pyra2 ol-4-yl] -2H-tetrazolc; 2-benzyl-5-[5-chloro-1-(4-methoxyphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[5-chloro-1-(4-mcthoxyphenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 2-benzyl-5-[5-ehloro-t-(2-methylphenyl)-1 H-pyrazoh4-yl]-2H-tctrazolc; I -benzyl-5-[5-ehloro-I -(2-methytphenyl)-1 H-pyrazok4-yl]-2F1-tetrazole; 2-benzyl-5-[5-chloro-I -(4-methyiphenyl)-I H-pyrazol-4-yI] -2H -tetTazole; 1 -benzyl-5-[5-ehloro-I -(4-methylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-bcnzyl-5-(5-bromo-1 -methyl-I H-pyrazol-4-yl)-21T-tetrazole; 1-henzyl-5-(5-hrorno-I -rncthyl-1H-pyrazol-4-yI)-2H-tetrazole; 2-benzyl-5-(5-bromo-1-ethyl-1H-pyrazol-4-yl)-21-1-tetrazole; 1-henzyl-5-(5-hromo-1 -ethyl-I 1-1-pyrazot-4-yl)-2H-tetrazole; 2-benzyl-5-[5-bromo-1 -(2-methylpropyl)-IU-pyrazol-4-yll-21-T-tetrazole; I-henzy!-5-[5-bromo-I-(2-methylpropyl)-IH-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-(I -benzyl-5 -bromo-1 H-pyrazol-4-yl)-21 1-tetrazole; I -benzyl-5-(1 -benzyl-5-brorno-1H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-(5-brorno-1 -phenyl-1 II-pyrazol-4-yl)-2 H-tetrazole; I -benzy-5-(5-bromo-I -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; 2-benzyl- -bromo-I -(2-cHorophenyl)-1 H-pyrazol-4-y]j -2H-tetrazole; I -benzyl-5-[5-brorno-I -(2-ehlorophenyl)-1II-pvrazol-4-yli-2H4etrazole; 2-benzy1-5-[5-bromo-I-(3-chIoropheny-1H-pyrazo1-4-y1-2H-tetrazo1e; 1 -benzyl-5-[5-brorno--1-(3-ehlorophenyl)-1II-pvrazol-4-yfl-2H-tetrazole; 2-benzyl-5-[5-hromo-1 -(4-ehlorophenyl)-1H-pyrazol-4-yfl-21I-tetrazole; 1-benzy1-5-[5-bromo-1-(4-ehloropheny-1 H-pyrazol-4-ylj-21-1-tetrazole; 2-benzy1-5-[5-bromo-1-(2,3-dichloropheny1)-1H-pyrazol-4-y1-2H-tetrazo1e; 1 -benzyl-5-[5-bromo-1 -(2,3-dichiorophenyl)-1 H-pyrazo]-4-ylj-2H-tetrazole; 2-benzyl-5-[5-hronio-1 -(2,4-dichlorophenyl)-1ll-pyrazol-4-yl]-2H-tctrazole; I -benzyl-5-[5-brorno-1 -(2,4-dichiorophenyl)-1H-pyrazol-4-yfl-21-I-tetrazole; 2-benzyl-5-[5-bromo-1 -(2,5-dichlorophcnyl)-1 T-1-pyrazol-4-yl]-2H-tetrazole; I -henzyl-5-[5-bromo-1-(2,5-dichlorophenyl)-I 1-T-pyrazol-4-yl]-2H-tetrazole; 2-henzyl -5-{5-brorno-1 -(2,6-dichlorophenyl)-I H-pyrazol-4-yl]-21 1-tetrazole; 1-benzyl-5-[5-bromo-I -(,6-dichlorophcnyl)-1H-pyrai.ol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-bromo-1-(3,4-dicblorophenyl)-IfI-pyrazol-4-yl]-2H-tctrazole; 1-benzy!-5-[5-hrorno-I -(3,4-dicblorophenyl)-IH-pyrazol-4-yl]-211-tetrazole; 2-benzyl-5-[5-brorno-1-(3,5-dichlorophenyl)-IH-pyrazol-4-yl I-2H-tetrazole; 1-benzy!-5-[5-hromo-I -(3,5-dicblorophenyl)-IH-pyrazol-4-yl]-2H-tctrazolc; 2-benzyl-5-[5-bromo-1-(2-bromophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5-broino-I -(2-bromophenyl)-1 H-pyrazol-4-yl] -2H-tetrazole; 2-henzy!-5-[5-hromo-I -(3-brornophenyl)-1IJ-pyrazol-4-yF]-21-I-tetrazole; 1-bcnzyl-5-[5-brorno-I -(3-brornophenyl)-I H-pyrazol-4-ylj-21-I-tetrazole; 2-benzyl-5-[5-bromo-1-(4-bromophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -berizyl-545-brorno-1-(4-bromophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-brorno-I -(4-fluorophenyl)-I H-pyrazol-4-yl]-21-I-tetrazole; 1-henzyl-5-[5-hromo-I -(4-fluorophcnyl)-I H-pyrazol-4-yl]-21-1-tetrazole; 2-benzyl-5-[5-bromo-1 -(2-fluorophenyl)-1 II-pyrazol-4-yl]-21-I-tetrazole; 1-benzyl-5-[5-bromo-1-(2-fluorophenyl)-I H-pyrazol-4-yIj-2F1-tetrazole; 2-benzyl-5-[5-brorno-1-(2,3-dichlorophenyl)-I H-pyrazol-4-yl]-2F1-tetrazole; 1-henzyl-5-[5-hromo-1-(2,3-dichlorophenyl)-I H-pyrazol-4-yIj-2H4etrazole; 2-benzyl-5-[5-brorno-1-(2,4-dichlorophenyl) -1H-pvrazol-4-yfl-211-tetrazole; I -bcnzyi-5-[5-brorno-I -(2,4-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzy1-5-[5-bromo-1-(2,5-dich1orophdny1)-III-pyrazo1-4-y1-2H-tetrazo1e; I -bcnzyl-5-[5-bromo-1-(2,5-dichlorophenyl) -11-1-pyrazol-4-ylj-21-1-tetrazole; 2-benzyl-5{5-bromo-1-(2,6-dichlorophenyl)-1 H-pyrazo!-4-yI]-2H-tetrazole; 1-henzyl-5-[5-brorno--(2,6-dichlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[3-bromo-1-(3,4-dichlorophenyl)-l H-pyrazol-4-yl]-21-I-tctrazole; 1 -benzyl-5-[5-brorno-1 -(3,4-dichlorophenvl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-hromo-I -(3,5-diehiorophenyl)-1H-pyrazol-4-ylj-2H-tetrazole; 1-benzyl-5-[5-bromo-1-(3,5-dichlorophenyl)-1II-pyrazol-4-yl] -211-tetrazole; 2-benzyl-5-[5-bromo-1-(2-cthylphcnyl)-1 1I-pyrazol-4-ylj-2H-tetrazole; 1 -benzyl-5-[5-brorno-l-(2-ethylphenyl)-1 II-pyrazol-4-ylJ-2H-tetrazole; 2-henzyl-5-[5-hromo-I -(4-ethylphenyl)-1 H-pyrazol-4-ylj-2H-tetrazole; l-bcnzyl-5-[5-hrorno-1 -(4-ethylpheny[)-l H-pyrazol-4-yl]-2H-tetrazole; 2-benzyl-5-[5-brorno-1 -(4-methoxyphenyl)-1H-pyrazol-4-yl] -2H-tctrazole; I -benzyl-5-[5-hromo-1-(4-methoxyphenyl)-lII-pyrazol-4-yfl-211-tetrazole; 2-benzvl-5-[5-brorno-l-(2-methylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[5-bromo-l-(2-rnethylphenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 2-bcnzyl-5-[5-hromo-1-(4-methylphenyl)-11-1-pyrazol-4-yl]-21-1-tetrazole; 1 -benzyl-5-[5-hromo-I -(4-niethylphenyl)-H-pyrazol-4-yI]-2H-tetrazole; 2-benzyl-5-(5-iodo-i-methyl-1H-pyrazol-4-yl)-211-tetrazole; 1 -henzyl-5-(5-iodo-1 -methyl-I H-pyrazol-4-yI)-2H-tetrazole; 2-benzyl-5-( 1 -ethyl-5-iodo-1 I-1-pyrazol-4-yl)-21T-tetrazole; 1-benzyl-5-(1-ethvl-5-iodo-1I-1-pyrazol-4-yl)-2H-tetrazole; 2-benzyl-5-{5-iodo-1 -(2-methylpropyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[5-iodo-l-(2-methylpropyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 2-benzyl-5-(l-benzyl-5-iodo-1I1-pyrazol-4-yl)-2H-tetrazole; 1 -benzyl-5 -(1 -benzyl-5-iodo-1FI-pyrazol-4-yl)-21 1-tetrazole; 2-benzyl-5-(5-iodo-1 -phenyl-IH-pyrazol-4-yI)-2H-tetrazole; 1 -benzyl-5 -(5-iodo-1 -phenyl-I FI-pyrazol-4-yl)-2H-tetrazole; 2-herizyl-5-[1 -(2-ehlorophenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 1 -benzyl-5-[1 -(2-ehlorophenyl)-5-iodo-1II-pyrazol-4-yll-21I-tetrazole; 2-benzyl-5-[I -(3-ehlorophenyl)-5-iodo-1H-pyrazol-4-ylJ-2H-tetrazole; 1 -benzyl-5-[1 -(3-chlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; 2-benzy1-5-[1-(4-ch1oropheny1)-5-iodo-1H-pyrao1-4-y1]-21-1-tetrazo1e; I -benzyl-5-[I -(4-ehlorophenyl)-5-iodo-I H-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[1 -(2,3-diehlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-21-I-tetrazole; l-benzyl-5-{1-(2,3-dichlorophenyl)-5-iodo-1 H-pyrazo1-4-ylj-2H-terazo1e; 2-benzyl-5-[1 -(2,4-dicHoropheny1)-5-iodo-1I-i-pyrazo1-4-y1-2Ii-tetrazole; 1-benzyl-5-[1 -(2,4-dichlorophenyl)-3-iodo-1 H-pyrazoU4-yij-2H-tetrazole; 2-henzyl-5-[1 -(2,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-211-tetrazole; 1-benzyl-5-[1 -(2,5-dichlorophenyl)-5-iodo-I H-pyrazo1-4-y1]2H-tetrazo1e; 2-bcnzyl-541 -(2,6-dichlorophenyl)-5-iodo-lT-1-pyrazol-4-yI]-2H-tetrazole; 1-benzyl-5-[1-(2,6-dkh!orophenyl)-5-iodo-1H-pyrazol-4-yl]-2f1-tctrazole; 2-bcnzy1-5[1 -(3,4-dichiorophdllyl)-5-iodo-1F1-pyrazo1-4-y1-2H-tetrazoIe; 1-benzyl-5-[1-(3,4-dichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tctrazolc; 2-benzyl-5-[1-(3,5-dichlorophenyl)-5-iodo-I i-I-pyrazol-4-ylj-211-tetrazole; I -benzyl-5-[1-(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2H-tetrazole: 2-bcnzyl-5-[1 -(2-hrornopheny])-5-iodo-1II-pyrazol-4-yl]-2H-totrazole; 1-benzyl-5-[1-(2-brornophenyl)-5-iodo-i H-pyrazol-4-ylj-21-I-tetrazole; 2-benzyl-5-[I -(3-brornopheny1)-5-iodo-1I-T-pyrazoI-4-yI-2H-tetrazoIe; 1 -henzyl-5-[I -(3-hrornopheny1)-5-iodo-1H-pyrazo1-4-y1-2II-tetrazoIe; 2-benzyl-5-[1-(4-bromophenyl)-5-iodo-H-pyrazol-4-ylj-2H-tetrazole; 1 -benzy1-5-[1-(4-bromopheny1)-5-ioc1o-1JJ-pyrazo1-4-y1-2H-tetrazoIc; 2-benzyl-5-[1-(4-fluorophenyl)-5-iodo-1 H-pyrazol-4-yIJ-2H-tetrazole; 1-benzyl-5-[1-(4-Iluorophenyl)-5-iodo-1II-pyrazol-4-ylJ-2H-tetrazolc; 2-henzyl-5-[1 -(2-fluorophenyl)-5-iodo-IH-pvrazol-4-yl]-2H-tetrazolc; 1-benzyl-5-[1-(2-fluorophenyl)-5-iodo-i H-pyrazol-4-ylJ-2H-tetrazole; 2-benzyl-5-[1 -(2.3 -dimethylphenyl)-5-iodo-1 H-pyrazol-4-yl] -2H-tetrazole; I -bcnzyI-5-1 -(2.3-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazo!e; 2-bcnzyl-5-[1 -(2,4-dirnethylplienyl)-5-iodo-1FI-pyrazol-4-yll-21I-tetrazole; 1 -benzyl-5-[1 -(2,4-dimethylplicnyl)-5-iodo-I H-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[ I -(2,5-dirnethylplienyl)-5-iodo-1I1-pyrazol-4-yl]-2H-tctrazole; 1 -benzyl-5-[1 -(2,5-dirnethylphenyl)-5-iodo-I 1-I-pyrazol-4-ylj-21-I-tetrazole; 2-benzyl-5-[1 -(2,6-dimethylphenyl)-5-iodo-I T-T-pyrazol-4-yI]-2H-tetrazole; 1 -henzyl-5-[1 -(2,6-diniethy]phenyl)-5-iodo-1H-pyrazol-4-ylj-21-1-tetrazole; 2-benzyl-5-[1-(3,4-dimethylphenyl)-5-iodo-1fl-pyrazol-4-yI] -21-1-tctrazole; 1 -benzyl-5-[1-(3,4-dirnethylphenyl)-5-iodo-1H-pyrazol-4-yll-211-tetrazole; 2-benzyl-5-[1-(3,5-dimethylphenyl)-3-iodo-I I-1-pyrazol-4-ylj-2H-tetrazole; 1benzy1-5-[1-(3,5-dirnethy1pheny1)-5-iodo-1II-pyrazo1-4-y1]-2H-tetrazoTe; 2-benzyl-5-[1 -(2-ethy!pbenyl)-5-iodo-I H-pyrazol-4-yl]-2H-tetrazole; 1-benzyl-5-[1 -(2-cthylpheny!)-5-iodo-1H-pyrazol-4-ylj-2H-tetrazole; 2-benzyl-5-[1 -(4-ethylphenyl)-5-iodo-1 f-1-pyrazol-4-y]j-2H-tetrazole; 1-henzyl-5-[l -(4-cthylphenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 2-bemzyl-5-[5-iodo-1-(4-methoxyphenyl)-l H-pyrazol-4-yl]-2H-tetrazole; S 1-henzyl-5-[5-iodo--(4-rnethoxyphenyl)-1ll-pyrazol-4-yI]-2H-tetrazole; 2-benzyl-5-[5-iodo-l -(2-methyiphenyl)-1 H-pyrazo1-4-y1j2Htetrazo1e; I -benzyl-5-[5-iodo-1-(2-methylpheny1)-1JJ-pvrazo1-4-yI-2J-T-tetrazole; 2-benzyl-5-[5-iodo-1-(4-rnetliylphenyl)-1H-pyrazol-4-yl]-2H-letrazole; I -benzyl-5-[5-iodo-1 -(4-rnethylplienyl)-1H-pyrazol-4-yIl-2H-tetrazole; 2-(4-brornobenzyl)-5-( I -rnethyl-11-1-pyrazol-4-yl)-211-tetrazole; I -(4-bromobenzyl)-5-(l -methyl-I H-pyrazol-4-yl)-2H-teUazo1e; 2-(4-bromobenzyl)-5 -(1-ethyl-i H-pyrazol-4-yl)-2H-tetrazole; 1-(4-hrornohenzy!)-5-(I -ethy]-iFI-pyrazol-4-yl)-2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2-methyipropyl)-I H-pyrazol-4-yI]-2H-tetrazole; I -(4-bromobenzyl)-5-l -(2-methylpropyl)-I 1-T-pyrazol-4-yl]-2H-tetrazole; 5-(l -benzyl-I H-pyrazol-4-yl)-2-(4-bromobenzyl)-211-tetrazole; 5-(1 -benzyl-i fl-pyra2ol-4-yI)-I -(4-brornobenzyl)-2H-tetrazole; 2-(4-hrornohenzyl)-5 -(1 -phenyl-1 I-1-pyrazol-4-yl)-21 1-tetrazole; 1-(4-bromobenzyl)-5-(l-phenyl-I H-pyrazol-4-yI)-2H-tetrazole; 2-(4-bromobenzyl)-5 -[1 -(2-ehlorophenyl)-11 1-pyrazol -4-yl] -2H-tetrazole; 1 -(4-bromobenzyl)-5 -[1 -(2-ehlorophenyl)-i H-pyrazol-4-yl]-211-tetrazole; 2-(4-bromobenzyl)-5 -[I -(3 -ehlorophenyl)-1 H-pyrazol-4-yl]-211-letrazole; 1-(4-bromobenzyl)-5-l -(3-chlorophenyl)-I H-pvrazol-4-yi]-2H-tetrazole; 2-(4-bromobenzyl)-5-11 -(4-ehlorophenyl)-iH-pyrazol-4-yl]-21-I-tetrazole; I -(4-bromobenzyi)-5-1 -(4-ehlorophenyl)-iH-pyrazol-4-yi]-2H-tetrazolc; 2-(4-bromobenzyl)-5-[l -(2.3-diehiorophenyl)-I H-pyrazol-3-yl]-2H-tetrazole: 1-(4-brornobenzyl)-5-l -(2,3-diehlorophenyl)-1H-pyrazol-3-yl]-2H-tetrazole; 2-(4-hromohenzyl)-5-[1 -(2,4-diehlorophenyl)-1H-pyrazol-4-yl]-21-i-tetrazole; 1-(4-brornobenzyl)-5-Il -(2,4-dichlorophenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1-(2,5-diehlorophenyl)-1H-pyrazol-4-yl] -211-tetrazole; 1-(4-bromobenzyl)-5-[l -(2,5-dichlorophenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1 -(2,6-dichlorophenyl)-1I1-pyrazol-4-yl]-2fl-tetrazole; 1 -(4-hromohenzyl)-5-[l -(2,6-diehlorophenyl)-11-I-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1-(3.4-diehlorophenyl)-1 1-T-pyrazol-4-y1]-2H-tetrazole; 1-(4-bromobenzyl)-5-[i -(3,4-diehlorophenyl)-1 H-pyrazo1-4-y]-2H-tetrazo1e; 2-(4-bromobenzyl)-5-{1 -(3,5-diehiorophenyl)-1 H-pyrazol-4-yl]-211-tetrazole; I -(4-hromobenzyl)-5-[1-(3,5-dichlorophenyfl-1I-I-pyrazol-4-y!] -2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(2-broniophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-bromobenzyl)-5-[1 -(2-bromophenyl)-1 H-pyrazoi-4-yl]-2H-tetrazole; 2-(4-bromobenzy1)-5-1 -(3-brornopheny1)-1I-I-pyrazo1-4-y1-21-1-tetrazoIe; 1-(4-brornobenzy1)5-[1 -(3-bromophenyl)-H-pyrazoh4--ylJ-2H-tetrazole; 2-(4-brornobenzyl)-5-[I -(4-brornophenyl)-1H-pyrazol-4-yl]-2F1-tetrazolc; 1-(4-brornobenzy1)-5-[1-(4-bromophenyI)-H-pyrazol-4-ylj-21-i-tetrazole; 2-(4-brornobenzyl)-5-[1 -(4-iluorophenyl)-1H-pyrazol-4-yl] -2H-tetrazole; 1-(4-brornohenzyl)-5-[I -(4-fluorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1-(2-fluorophenyl)-I H-pyrazol-4-yI]-21-I-tetrazole; I -(4-bromobenzyl)-5-[1 -(2-tluorophenyl)-1H-pyrazol-4-yl] -2H-tetrazole; 2-(4-brornohenzyl)-5-[I -(2,3-dimethyiphenyl)-1 I-I-pyrazol-4-y]j-21 1-tetrazole; 1 -(4-bromobenzyl)-5-[1-(2,3-dirnethylphenyl)-H-pyrazol-4-yIj-2F1-tetrazole; 2-(4-brornobenzyl)-5-[1 -(2,4-dirnethyiphenyl)-1 H-pyrazol-4-yI]-21-1-tctrazolc; I -(4-bromobenzyl)-5-[1 -(2,4-dimethyiphenyl)-1 I-1-pyrazol-4-yl]-211-tetrazole; 2-(4-bromobenzy1)-5-[1-(2,5-dimethyIphcny-H-pyrazol-4-yIj-2H-tetraznle; 1 -(4-bromobenzyl)-5 -[1 -(2,5 -diniethyiphenyl)-I H-pyrazol-4-yl]-21 1-tetrazole; 2-(4-hromobenzyl)-5-[1 -(2,6-dimethylphcny1)-1H-pyrazo1-4-y1j2R-tetrazo1e; 1-(4-bromobenzyl)-5-[1-(2,6-dimethylphenyl)-1 H-pyrazol-4-yi]-2H-tctrazole; 2-(4-brornobenzyl)-5-[1 -(3,4-dimethyiphenyl)-1 H-pyrazol-4-yl]-211-tctrazole; I -(4-hrornobenzyl)-5-[1 -(3,4-dimethyiphenyl)-1II-pyrazol-4-yl]-211-tetrazole; 2-(4-bromobenzyl)-5-[1-(3,5-dimethy1pheiiy-1 H-pvrazol-4-yl]-2H-tetrazole; 1 -(4-bromobenzyl)-5-[1 -@ ,5-dimethylphenyl)-1I-I-pyrazol-4-yI]-2H-tetrazole; 2-(4-hrornohenzyl)-5 -[1 -(2-ethylphenyl)-H-pyrazol-4-yl] -2H-tetrazole; 1-(4-bromobenzyl)-5-[1-(2-ethylphenyl)-1 H-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobenzyl)-541 -(4-ethyiphenyl)-1II-pyrazol-4-yll-2H-tetrazole; 1 -(4-bromohenzyl)-5-[1 -(4-ethyiphenyl)-I R-pyrazo]-4-yJj-2H-tetrazole; 2-(4-bromobenzyl)-5 -[1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-21 1-tetrazole; 1 -(4-hromohenzyl)-5-[I -(4-methoxyphenyl)-1H-pyrazol-4-ylj-2H-tetra2ole; 2-(4-bromobenzyl)-5 -I -(2-methyiphenyl)-1 II-pyrazol-4-yl]-2H-tetrazole; I -(4-hrornobenzyl)-5 -[1 -(2-methyiphenyl)-1 H-pyrazol-4-y1]-2H-tetrazole; 2-(4-brornobenzyl)-5-[1-(4-rnethylphenyl)-1 H-pyrazol-4-yI]-2H-tetrazole; 1-(4-bromobenzyl)-5-[T -(4-niethylphenyl)-IH-pyrazol-4-yl]-211-tetrazole; 2-(4-broniobenzy)-5-(5-ch1oro-1-methyl-I H-pyrazol-4-yI)-2H-tetrazole; 1-(4-bromobenzy)-5-(5-chIoro-1 -methy1-1H-pyrazo1-4-y)-2H-tetrazo1e; 2-(4-hroniobenzyl)-5-(5-chloro-1-ethyl-IH-pyrazol-4-yl)-2H-tetrazole; 1 -(4-bromobenzy-5 -(5-ehi oro-1-ethyl-i H-pyrazol-4-yl)-21I-tetrazole; 2-(4-bromobenzyl)-5-5-chloro-1 -(2-niethylpropyl)-IH-pyrazol-4-yl]-211-tctrazole; 1-(4-bromobenzyl)-5-[5-chloro-1-(2-methylpropyl)-1H-pyrazol-4-yl] -21-J-tetrazole; 5-(1-becizyL-5-chloro-1iI-pyrazol-4-yl)-2-(4-hrornobenzvl)-2H-tetrazole; 5-(1 -benzyl-5-ehloro-IH-pyrazol-4-yl)-i-(4-bromobenzyl)-2H-tetrazole; 2-(4-bromobenzyl)-5-(5-chl oro-1 -phenyl-1 I-I-pyrazol-4-yl)-2H-tetrazole; 1 -(4-bromobenzyl)-5 -(5-ehioro-I -phenyl -I H-pyrazol-4-yl)-21 1-tetrazole; 2-(4-brornobeniy1)-5-[5-eh1oro-I-(2-ch1oropheny)-1H-pyrazoI-4-yI] -2H-tietrazo1e; 1-(4-bromobenzyl)-5-[5-ehloro-I -(2-cfflorophenyl)-1II-pyrazol-4-yIJ-21-T-tetrazole; 2-(4-bromobenzyl)-5-[5-ehloro-1 -(3-chlorophenyl)-1H-pyrazol-4-ylj-21-I-tetrazole; 1-(4-bromobenzyl)-5-[5-ehloro-1-(3-cffloropheny!) -f-1-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobenzyl)-5 -{5-eh loro-I -(4-chlorophenyl)-i H-pyrazo1-4-yl-2I 1-tetrazol e; 1-(4-brornobenzyl)-5-[5-chloro-1 -(4-ch]orophcnyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-ehloro-i-(2,3-diehlorophenyl) -IH-pyrazol-4-yij-2H-tetrazole; i-(4-bromobenzy1)-5-[-ehIoro-1 -(2,3-dieh1oropheny1)-iH-pyrazo1-4-y1-2II-tetrazo!e; 2-(4-bromobenzy1)-5-[5-ehloro-1-(2.4-dich1oropheny-I U-pyrazol-4-ylj-2H-tetrazole; i-(4-bromohenzyl)-5-[5-ehloro-1-(2,4-diehlorophenyl)-1H-pyrazol-4-y!] -2H-tetrazole; 2-(4-bromobenzyl)-5-[5-ehloro-I -(2,5-diehlorophenyl)-iH-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyi)-5-[5-ehloro-1 -(2,5-diehlorophenyl)-1H-pyrazol-4-y]j-2H-tetrazole; 2-(4-hromobenzyl)-5-[5-ehloro-1-(2,6-diehlorophcnyl)-1H-pyrazol-4-yl] -2H-tetrazole; 1 -(4-brornobenzyl)-5-[5-chloro-] -(2,6-diehlorophenyl)-1H-pyrazol-4-yI]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-i-(3,4-diehlorophenyl)-I H-pyrazol-4-yl]-211-tetrazole; 1-(4-bromobenzy-5-[5-ch1oro-1-(3,4-dichhrophenyI)-IT-1-pyrazoI-4-y1] -2H-tetrazo1e; 2-(4-bromobenzy)-5-[5-chIoro-I -(3,5-diehlorophenyl)-1H-pyrazol-4-yfl-21-i-tetrazole; I -(4-bromobenzy)-5-[5-eh1oro-1-(3,5-dich1oropheny1)-1fI-pyrazo1-4-yI]-2F- [-tetrazo1e; 2-(4-bromobenzyl)-5-[1-(2-hromophenyl)-5-chloro-1H-pyrazol-4-yl] -2H-tetrazole; 1-(4-bromobenzyl)-5-[1 -(2-brornophenyl)-5-eh!oro-I H-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromohenzyI)-5-[I-(3-broniopheny1) -5-ch1oro-1H-pyrazo1-4-y1-2H-tetrazoIc; 1-(4-bromobenzy1)-5-[1-(3-bromophenyI) -5-ehIoro-IH-pyrazo1-4-y1-2H-tetrazo1c; 2-(4-brornobenzy1)-5-j-(4-brornopheny1) -5-ch1oro-1I-i-pyrazo1-4-yl-2H-tetrazoIe; 1-(4-bromobenzyl)-5-[1-(4-bromophenyl)-5-ehloro-I H-pyrazol-4-y[]-2H-tetrazole; 2-(4-brornobenzy1)5-[5-eh1oro-1 -(4-iluorophenyl)-1 H-pyrazol-4-yl]-21-{-tetrazole; 1-(4-brornobenzyl)-5-[5-ehloro-1-(4-fluorophenyl)-1 H-pyrazol-4-yl]-21-1-tetrazole; 2-(4-hrornobenzyl)-5-[5-ehloro-1 -(2-iluorophenyl)-1 H-pyrazol-4-yl]-2R-tetrazole; 1 -(4-bromobenzyl)-5 -[5-ehioro-I -(2-fiuoropheny-1-1-pyrazo] -4-ylj-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-ehloro-1-(2,3-dirnethylpheny])-1H-pyrazol-4-yl] -2H-tetrazole; 1 -(4-bromobenzyl)-5-[5-eh]oro-i-(2,3-dirnethvlphenyl) -1II-pyrazol-4-yfl-211-tetrazole; 2-(4-bromobenzyl)-5-[5-ehloro-1-(2,4-dimethvlphenvl)-1H-pyrazol-4-yl] -21-1-tetrazole; I -(4-bromobenzyfl-5-[5-chloro-1-(2,4-dimethylphenyl) -1II-pyrazol-4-yfl-211-tetrazole; 2-(4-bromobeitzyl)-5-[5-ehloro-1-(2,5-dirnethylphenyl)-I H-pyrazol-4-yI]-2Ff-tetr'azole; 1-(4-bromobenzyl)-5-[5-ehloro-] -(2,5-dimcthy]phcnyl)-I T-T-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornoberrzyl)-5-[5-ehloro-1 -(2,6-dimethyiphenyl)-1H-pyrazol-4-yfl-211-tetrazole; -(4-bromobenzy])-5-[5-eh]oro-i -(2,6-dirnethvlphenyl)-IFI-pyrazol-4-yl]-2H-teirazole; 2-(4-bromobenzy1)-5-[5-ch1oro-1-(3,4-dimethy1pheny-11-I-pyrazol-4-yE] -2H-tctrazole; 1 -(4-brornobenzyl)-5-[5-ehloro-1 -(3,4-dimethyiphenvi)-1H-pyrazol-4-yfl-211-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-I -(3,5-dimethy]phenyl)-I H-pyrazol-4-ylj-2H-tetrazole; 1-(4-bromobenzyl)-5-[5-chloro-l-(3,5-dimethylpheny]) -11-T-pyrazo!-4-yfl-2H-tetrazole; 2-(-bromobenzy])-5-[5-ehIoro-I -(2-elhylphenyl)-1J-i-pyrazol-4-yl]-2F1-tetrazole; 1-(4-brornobcnzyl)-5-[5-chloro-1-(2-ethylphenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-eh]oro-1 -(4-ethylphenyl)-1II-pyrazol-4-yl]-2H-tetrazole; I -(4-hrornohenzyl)-5-[5-ch]oi-o-I -(4-e.thylphenyl)-1H-pyrazol-4-ylj-2H-tetrazole; 2-(4-broinobcnzyl)-5-[5-chloro-1-(4-methoxyphenyl)-IH-pyrazol-4-yl] -2H-tetr'azole; 1 -(4-bromobenzyl)-5-[5-chloro-1 -(4-methoxypheny])-IH-pyrazol-4-ylJ-2H-tetrazo!e; 2-(4-hrornobenzyl)-5 -[5 -chloro-1 -(2-methyiphenyl)-1 lT-pyrazol-4-yl] -2H-tetrazole; 1 -(4--bromobenzyl)-5-[5-chloro-1 -(2-methylphenyl)-1 H-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-chloro-1-(4-methylphenyl)-I I-I-pyrazol-4-yl]-2H-tetrazo]e; 1 -(4-bronobenzyl)-5-[5-chloro-1 -(4-methylphenyl)-1 H-pyrazol-4-yl]-211-tetrazole; -methyl-H-pyrazol-4-yI)-2H-tetrazoie; 1-(4-brornobenzyl)-5-(5-brorno-1-methyl-IH-pyrazol-4-yl)-2H-tetrazole; 2-(4-bromohenzy])-5-(5-hromo-I -ethyl-I H-pyrazo]-4-y])-2H-tetrazole; 1 -(4-brornobenzyl)-5-(5-bromo-1-ethyl-lI I-pyrazol-4-yl)-211-tctrazole; 2-(4-brornobenzy])-5-[5-bromo-1 -(2-rnethylpropyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobcnzyl)-5-[5-bromo-1-(2-methylpropyl)-IH-pyrazol-4-yl] -2H-tetrazole; 5-(]-benzyl-5-bromo-1H-pyrazol-4-yl)-2-(4-brornobenzyl)-211-tetrazole; 5-(1-benzyl-5-bromo-IH-pyrazol-4-yl)-1-(4-bromohenzyl)-21-J-tetrazole; 2-(4-bromobenzy)-5-(5-bronio-I -phenyl-1H-pyrazol-4-yl)-2F1-telrazole; 1 -(4-brornobenzyl)-5-(5-bromo-1 -phenyl-1iI-pyrazol-4-yl)-211-tetrazole; 2-(4-brornobenzyl)-5-5-bromo-1 -(2-chlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobenzy1)-5-5-bromo-1 -(2-chlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-brorno-1 -(3-ehlorophcnyl)-1II-pyrazol-4-yIl-21-1-tetrazole; 1-(4-bromobenzyl)-5-[5-hromo-1 -(3-ch1oropheny1)-1H-pyrazoh4-y1]2II-tetrazo1e; 2-(4-bromobenzyl)-5-[5-bromo-1 -(4-chlorophenyl)-1II-pyrazol-4-yl]-2H-tetrazole; I -(4-bromobenzyl)-5-[5-brorno-] -(4-chloroplienyl)-1H-pyrazol-4-yli-211-tetrazole; 2-(4-bromobenzyl)-5-[5-brorno-1 -(2,3-diehlorophenyl)-1 H-pyrazol-4-yI]-2H-teuazole; I -(4-bromobenzyl)-5-[5-bromo-1 -(2,3-diehlorophenyl)-1FI-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-brorno-1 -(2,4-dichloroplienyl)-1 H-pyrazo]-4-yI]-2H-tetrazole; 1-(4-brornobenzyl)-5-[5-hromo-1 -(2,4-dichloropbcnyl)-1H-pyrazol-4-yI]-2M-teuazole; 2-(4-brornobenzyl)-5-[5-bromo-1 -(2,5-dichlorophenyl)-1II-pyrazol-4-y!]-2H-tetrazole; 1 -(4-brornobcnzy)-5-[5-hromo-1 -(2,5-diehiorophenyl)-1H-pyrazol-4-yl]-21-I-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2,6-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 1 -(4-brornobenzyl)-5-[5-bromo-1 -(2,6-dichlorophenyl)-1H-pyrazol-4-yll-211-tetrazole; 2-(4-bromobenzy!)-5-[5-bromo-1 -(3,4-dichloropbenyl)-I H-pvrazol-4-yl]-2FT-teirazole; 1 -(4-brornobenzyl)-5-[5-brorno-1 -(3,4-dichlorophenyl)-1II-pyrazol-4-yIl-21T-tetrazole; 2-(4--bromobenzyl)-5-[5-bromo-1-(3,5-dichlorophenyl)-IH-pyrazol-4-yl] -211-tetrazole; 1-(4-bromohenzyl)-5-[5-hrorno-1 -(3,5-dichlorophenyl)-1H-pyrazol-4-ylj-211-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2-bromophcnyl)-I H-pyrazol-4-yI] -2H-tetrazole; 1 -(4-bromobenzyl)-5-[5-bromo-1 -(2-bromophenyl)-I H-pyrazol-4-yl] -2H-tctrazole; 2-(4-bromobcnzyl)-5-[5-bromo-1 -(3-bromophenyl)-] H-pyrazol-4-y]j-2H-tetrazole; 1 -(4-bromobenzyl)-5-[5-bromo-1 -(3-bromophenyl)-I H-pyrazol-4-yl] -2H-tetrazole; 2-(4-hrornohenzyl)-5-[5-bromo-I -(4-brornopheny1)-1H-pyrazo1-4-y1-2FI-tetrazo1e: I -(4-bromohcnzyl)-5-[5-brorno-1-(4-bromophenyl)-IH-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1-(4-fluorophenyl) -1H-pyrazol-4-vll-21-I-tetrazolc; 1-(4-hrornobenzyl)-5-[5-hromo--(4-fluorophenyl) -1H-pyrazol-4-ylj-2H-tetrarzole; 2-(4-brornobenzyl)-5-[5-bromo-1 -(2-fluorophenyl)-1 I1-pyrazol-4-yl]-21-T-tetrazole; I -(4-hrornobenzy1)-5-[5-brorno-1 -(2-fluorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2,3-dimethylphenyl)-I H-pyrazol-4-yI]-2H-tetrazole; 1-(4-bromobenzyl)-5-[5-bromo-1 -(2,3-dimethylphenyl)-IH-pyrazol-4-yll-211-tetrazole; 2-(4-hromobenzyl)-5-[5-bromo--(2,4-dirnethylphenyl)-l J-i-pyrazol-4-ylj-2H-tetrazole; I -(4-bromobenzyl)-5-[5-brorno-1-(2,4-dirnethylphenyl)-1fl-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-I -(2,5-dirnethylphenyl)-1H-pyrazol-4-yl]-2H-letrazole; I -(4-brornobenzyl)-5-[5-bromo-1-(2,5-dirnethylphenyl)-1II-pyrazol-4-yl] -2H-tetrazolc; 2-(4-hromobenzyl)-5-[5-brorno-1 -(2,6-dirnethylphenyl)-1 H-pyrazol-4-yl]-211-tetrazcde; 1-(4-brornobenzyl)-5-[5-bromo-1-(2,6-dimethylphenyl)-i H-pyrazo1-4y1j-2H--tetrazo1e; 2-(4-brornobenzyl)-5-[5-brorno-1 -(3,4-dirnethylphenyl)-1 H-pyrazol-4-y!]-2H-tetrazolc; 1-(4-bromohenzyl)-5-[5-hromo-1 -(3,4-dimethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-bromo-1 -(3,5-dimethylphenyl)-1H-pyrazo1-4-y1-2H-tetrazo1e; 1-(4-hromobenzyl)-5-[5-bromo-1-(3,5-dimethylphenyl)-1TI-pyrazol-4-yl] -2H-tetrazolc; 2-(4-bromobenzyl)-5-[5-bromo-1-(2-ethylphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; I -(4-bromobenzyl)-5-[5-bromo-1 -(2-ethylphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzy)-5 -[5 -brorno-] -(4-ethyiphenyl)-1 H-pyrazol-4-yll-211-tetrazole; 1 -(4-bromobenzyl)-5-[5-bromo-1 -(4-ethyiphenyl)-I H-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobenzyl)-5-[5-bromo-1-(4-methoxyphenvl) -1T-1-pyrazol-4-yq-21-T-tetrazole; I -(4-brornobenzy1)-5-[5-brorno-1-(4-methoxyphenv1) -1H-pyrazo1-4-y1-2II-tetrazo1e; 2-(4-bromobenzyl)-5-[5-bromo-1 -(2-methylphenyl)-] H-pyrazol-4-yIj-2H-tetrazole; 1 -(4-bromobenzyl)-5-[5-bromo-1 -(2-methylphenyl)-1 I-T-pyrazol-4-yI]-2H-tetrazole; 2-(4-brornobenzyl)-5-[5-hromo-l (4-niethyIpheny1)-1H-pyrazo1-4-y1]-2II-tetrazo1e; 1-(4-bromobenzyl)-5-[5-bromo-1-(4-methylpheny!)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-(5-iodo-1-rnethyl-1H-pyrazol-4-yl)-21-I-tctrazolc; I -(4-brornobenzyl)-5-(5-iodo-1-rnethyl-1II-pyrazol-4-yl)-2F1-tetrazole; 2-(4-brornobcnzyl)-5 -(1 -ethyl-5-iodo-I H-pyrazol -4-yl)-2U-tetrazole; 1-(4-bromobenzyl)-5-(1-etliyl-5-iodo-1H-pyTazol-4-yl)-2H-tetrazole; 2-(4-hromobenzyl)-5-[5-iodo-1 -(2-methyipropyl)-1II-pyrazol-4-yl]-2H-tetrazole; 1-(4-brornobenzyl)-5-[5-iodo-1-(2-rnethylpropyl)-I H-pyrazo]-4-ylj-2H-tetrazole; 5-(1 -benzyl-5-iodo-1 II-pyrazol-4-yl)-2-(4-bromobenzyl)-21-1-tetrazole; 5-(1 -henzyl-5-iodo-I H-pyrazol-4-yl)-2-(4-bromobenzyl)-211-tetrazole; 2-(4-bromobenzyl)-5-(5-iodo-I -phenyl-1 H-pyrazol-4-yl)-2H-tetrazole; I -(4-brornobenzyl)-5-(5-iodo-1 -phenyl-11-1-pyrazol-4-yl)-21i1-tetrazole: 2-(4-bromobenzyl)-5-j1 -(2-chlorophenyl)-5-iodo-1 H-pyrazol-4-ylj-2H-tetrazole; 1-(4-brornobenzyl)-5-[1-(2-chlorophenyl)-5-iodo-11-T-pyrazol-4-yl] -2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(3-ehlorophenyl)-S4odo-1H-pyrazol-4-yl]-2H-tetrazole; 1-(4-bromobenzyl)-5-[1-(3-chlorophenyl)-5-iodo-1 H-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobcnzy1)-5-[1-(4-ch1oropheny1) -5-iodo-1H-pyrazo1-4-y1-2II-tetrazoIe; 1-(4-brornobenzyl)-5-[1-(4-ch]orophenyl)-5-iodo-IH-pyrazol-4-yl] -21-I-tetrazole; 2-(4-brornobenzy1)-5-[1-(2,3-dich1oropheny1)-5-iodo-1II-pyrazo1-4-y1} -2H-tetrazc1e; 1-(4-bromobenzyl)-5-[1 -(2,3-dichlorophcnyl)-5-iodo-1H-pyrazol-4-ylJ-2H-tetrazole; 2-(4-bromobenzy1)-5-[1-(2,4-dich1oropheny)-5-iodo-H-pyrazo1-4y1} -2H-tetrazo1e; 1 -(4-hromobenzy1)-541-(2,4-dich1oropheny1) -5-iodo-1H-pyrazo1-4-y1-2TI-tetrazole; 2-(4-brornobenzy1)-5-[1-(2,5-diehloropheny) -5-iodo-1H-pyrazo1-4-y1J-2H-tetrazo1e; I -(4-hrornobenzyl)-5-[1-(2,5-dichJorophenyl)-5-iodo-1II-pyrazol-4-yl] -21-1-tetrazole; 2-(4-brornobenzy1)-5-[1-(2,6-dichIoropheny)-5-iodo-1 H-pyrazol-4-yl]-2H-tetrazole; I -(4-bromobenzyl)-5-[1-(2,6-dichJorophcnyl)-5-iodo-IH-pyrazol-4-yI] -2H-tetrazole; 2-(4-brornohenzyl)-5-[1 -(3,4-diehlorophenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tetrazolc; 1-(4-broinobenzyl)-5-[1-(3,4-dichlorophenyl) -5-iodo-H-pyrazol-4-ylj-211-tetrazole; 2-(4-brornobenzy1)-5-[1-(3,5dicIiloropheny1)-5-iodo-1H-pyrazo1-4-y1] -2H-tetrazole; 1-(4-bromohenzyl)-5-[I -(3,5-dichlorophenyl)-5-iodo-1II-pyrazol-4-yll-21-T-tetrazo]e; 2-(4-bromobenzy1)-5-[1-(2-hromophcnyI)-5-iodo-IH-pyrazo1-4-y1] -2H-tetrao1e; 1-(4-bromobenzyl)-5-[1 -(2-bromophenyl)-5-iodo-1II-pyrazol-4-yI]-2H-tetrazole; 2-(4-bromohenzyl)-5-[1 -(3-bromophenyl)-5-iodo-IH-pyrazol-4-yl]-2H-tetrazole; 1-(4-hromohenzyt)-5-[1 -(3-broniophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-teftazole; 2-(4-bromobenzyl)-5-[1 -(4-bromophenyl)-5-iodo-1H-pyrazol-4-yll-21-1-tctrazole; 1-(4-hromobenzy-5-[1 -(4-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1-(4-fluorophenyl)-5-iodo-1II-pyrazol-4-y!] -21-I-tetrazole; 1 -(4-bromobenzyl)-5-[1 -(4-lluorophenyl)-5-iodo-IH-pyrazol-4-yl]-2H-tctrazolc; 2-(4-brornobenzyl)-5--[1 -(2-fluoropheny1)-5-iodo-1H-pyrazo1-4-y1-2iI-tetrazo1e; 1 -(4-broinobcnzyl)-5-[1 -(2-fluorophenyl)-5-iodo-I I-{-pyrazol-4-yl]-2H-tetrazole; 2-(4-bromobenzyl)-5-[1 -(23-dimethy1pheny1)-5-iodo-1H-pyrazo1-4-y1]-2H-tctrazo1c; 1-(4-brornobenzyl)-5-[1 -(2,3-dimethyIphenyI)-5-iodo-1H-pyrazo1-4-y1-2II-tetrazo1e; 2-(4-bromobenzyl)-5-[1 -(2,4-dimethylphenyl)-5-iodo-1H-pyrazo!-4-yI]-2H-tetrazole; 1 -(4-brornobenzyl)-541 -(2,4-dimethylphenyl)-5-iodo-1IT-pyrazol-4-yI]-2H-tetrazole; 2-(4-hromohenzyl)-5-[1 -(2,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2H-tetrazole; 1-(4-brornobenzyl)-5-[1-(2,5-dimethylphenyl)-3-iodo-1II-pyrazol-4-yI] -2H-tetrazole; 2-(4-hromobenzy!)-5-[1 -(26-dimcthy1pheny1)-5-iodo-1H-pyrazo1-4-y1]-2H-tetrazo1e; 1 -(4-bromobenzvl)-5-11-(2.6-dimethylphenvl)-5-ioclo-I H-pyrazol-4-yfl-2H-tetrazole; 2-(4-bromobcnzyl)-5-1-(3.4-dimethy1phenv1)-5-iodo-1H-pyrazo1-4-y1] -2II-tetrazo1e; 1-(4-bromobenzyl)-5-11 -(3,4-dimethyIphcnyI)-S-iodo-1H-pyrazo1-4-y1]2H-tetrazo1e; 2-(4-bromobenzy1)-5-[1-(3.5-diniethy1pheny1) -5-iodo-1IT-pyrazo1-4-y1-2H-tetrazoIe; 1-(4-bromobenzy)-54l -(3,5-dimethylphenyl)-5-iodo-1II-pyrazol-4-y!]-2H-tetrazole; 2-(4-bronobenzy1)-5-[1-(2-ethy1pheny)-5-iodo-iH-pyrazo1-4-y1] -2H-tetrazo1e; 1-(4-bromobenzyl)-5-[1-(2-ethylphenyl)-5-iodo-1II-pyrazol-4-yl] -2fl-tetrazole; 2-(4-bromobenzyl)-5.-[1 -(4-ethylphenyl)-5-iodo-1H-pyrazol-4-yl]-21I-tetrazole; 1 -(4-bronobenzyl)-5-[1-(4-ethylphenyl)-5-iodo-1 l-1-pyrazol-4-ylj-2H-tetrazole; 2-(4-bromobenzv1)-5-[5-iodo-1-(4-rnethoxyphenyl) -1H-pyrazo1-4-vl-2JI-tetrazoIe; 1-(4-brornobenzyl)-5-[5-iodo-1-(4-methoxyphenyl)-I H-pyrazol-4-yl]-21-I-tetrazole; 2-(4-bromobcnzyl)-5-[5-iodo-1 -(2-methyiphenyl)-11 I-pyrazol-4-yl]-2H-tetrazolc; 1 -(4-bromobenzyl)-5-[5-iodo-1 -(2-methylphenyl)-IH-pyrazol-4-yll-211-tetrazole; 2-(4-bromobenzyl)-5-[5-iodo-1-(4-methylphcnyl) -1H-pvrazol-4-ylj-2H-tetrazole; 1-(4-brornobenzyl)-5-[5-iodo-1-(4-methylphenyl) -1I-I-pyrazol-4-yfl-211-tetrazole; 4-{ 15-(1-methyl-1H-pyrazo1-4-y-2H-tetrazoI-2-yI]rnethyI}henzonitriIe; 4-{ [5-0 -methyl-I 1-I-pyrazol-4-yl)-11 1-tetrazol-I -yl]methyl} benzonitrile; 4-{ [5-(1 -ethyl-I H-pyrazol-4-yl)-2H-tetrazol-2-yljrnethyl}benzonitrile; 4-{ [5-(1-ethyl-1IT-pyrazol-4-yI)-1 H-tetrazol-I -yljmethyl}benzonitrile; 4-({5-[1-(2-rnethylpropyl)-1H-pyrazol-4-yl]-211-tetrazol-2-vl}methyl) benzonitrile; 4-({5-[1 -(2-mcthylpropyl)-1H-pyrazol-4-yl]-1H-tetrazol-1-yl}methyl)benzonitrile: 4-{[5-(1-benzyl-1IT-pyrazol-4-yl)-2H-tetrazol-2-yljrnethyl}benzonitdle; 4-{ [5-(1 -benzyl-I H-pyrazol-4-yl)-1 H-tetrazol-1 -yl]methyl}benzonitrilc; 4-([5-(1-phenyl-1IJ-pyrazol-4-yl)-2T-1-tetrazol-2-yI]methyl}benzonitrile; 4-{[5-(1-phenyl-1H-pyrazol-4-yl)-1H-tetrazol-1 -yI]methyl}benzonitrile; 4-({5-[1 -(2-chiorophenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}mcthvl)benzonitrile; 4-({5-[l -(2-eblorophenyl)-IH-pyrazol-4-ylj-IH-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1 -(3-ehlorophenyl)-1H-pyrazol-4-yl]-2H-tetrazoI-2-y}rnethyl)benzonitrile; 4-({5-[l -(3-chlorophenyl)-1I-I-pyrazol-4-ylj-1I-I-tetrazol-l -yl}methyl)benzonitrile; 4-({5-[1 -(4-chiorophenyl)-1 H-pyrazol-4-yfl-21-l-tetrazol-2-yi}rnethyl)benzonitrile; 4-5-[ 1 -(4-chiorophenyl)-1JI-pyrazol-4-y1]-I H-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[l -(2,3-dichlorophenyl)-1I-1-pyrazol-4-y1j-2H-tetrazol-2-yl}methyl) benzonitrile; 4-[ 5-[1 -(2,3-dicblorophenvl)-1II-pyrazol-4-yI]-I H-tetrazo-I -yl)methyl)benzonitrile; 4-({5-[l-(2,4-dichlorophenvl)-1I-1-pyrazol-4-yl]-21-1-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[l -( ,4-diehIorophenyl)-H-pyrazol-4-yl]-JFI-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[1-(2,5-dichlorophenyl)-1I-1-pyrazol-4-yfl-211-tetrazol-2-yI}methyl) benzonitrile; 4-({5-[l -(2,5-dichlorophenyl)-l1-i-pyrazol-4-yl]-1H-tetrazol-1-yl}methvl) benzonitrilc; 4-({ 5-[1 -(2,6-dichlorophcnyl)-1II-pyrazol-4-yI]-21-1-tetrazol-2-yl}methyl) benzonitrile; 4-( { 5-[1 -(2.6-diclilorophenyl)-1 II-pyrazol-4-yl]-1 Il-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(3.4-dichlorophenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[1 -(3,4-dichlorophenyl)-IU-pyrazol-4-y!i-IH-tetrazol-1-yl}rnethyl) benzonitrile; 4-({5-[1 -(3,5-dich1oropheny)-1 H-pyrazol-4-yl]-2H-telrazol-2-yl}methyl)benzonitrile; 4-({5-[1 -(3.5-dieh1oropheny)-H-pyrazol-4-yl]-1 H-tetrazol-1 -yI}methy!)henzonitrile; 4-({5-[1 -(2-bromophenyl)-1II-pyrazo1-4-y1-2II-tetrazo1-2-y1}rnethy1)benzonitri1e; 4-({5-[1 -(2-brornophenyl)-1H-pyrazol-4-yl]-1I--I-tetrazol-1 -yl}rnethyl)benzonitrile; 4-({ 5-[1 -(3-brornophenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl)benzoniLrile; 4-({5-[1-(3-bromophenyl)-1II-pyrazol-4-ylj-1II-tetrazol-1-yl}methyl) benzonitrfle; 4-({5-[1 -(4-brornophenyl)-I H-pyrazol-4-yl]-2H-tetrazol-2-yl} rnethyl)bcnzonitrile; 4-( { 5-[1 -(4-bromophenyl)-1 H-pyrazol-4-yl]-1 H-tetrazol-1-yl}methyl)benzonitrile; 4-5-[1-(4-fluoropheny1)-1H-pyrazo1-4-y1j-2M-tetrazol-2-yi}methyl) henzonitrile; 4-({5-[1 -( -fluoropIienyl)-H-pyrazol-4-yl]-1 H-tetrazol-I -y!}rnethyl)bcnzonitrile; 4-({5-[1 -(2-fluorophenyl)-1I1-pyrazol-4-yfl-211-tetrazol-2-yl}methyl)benzonitrile; -C( 5-[1-(2-fluorophenyl)-11-1-pyrazol-4-yl]-11-I-tetrazol-1-yl}rnethyl) benzonitrile; 4-({5-[1-(2,3-diniethylphcnyl)-H-pvrazol-4-yI]-2H-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[1 -(2.3-dimethypheny)-1TI-pyrazo1-4-y11-1II4etrazo1-1-v1}methy1) benzonitri1e; 4-({5-[1-(2.4-diniethy1pheny1)-l1T-pyrazo1-4-yl]2T4tetrazo1-2y}methy1) benzonitri1c; 4-( { 5 -[1 -(2,4-dimethyiphenyl)-11 I-pyrazol-4-yfl -11 1-tetrazol-1 -yl}methyl)benzonitrile; 4-(5-[1 -(2,5-dimethyiphenyl)-1H-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[1-(2,5-dimethylphenyl)-1II-pyrazol-4-yl]--IH-tetrazol-1-yl}methyl) benzonitrile; 4-({5-[i -(2,6-dimethylphenyl)-1 H-pyrazo!-4-yl-2H-tetrazcd-2-y1}mcthy1)benzonitri1e; 4-({5-[1 -(2.6-dimcthylphenyl)-1H-pyrazol-4-y]j-1H-tetrazol-1-yl}methyl) benzonitrile; 4-({5-[1-(3,4-dimethylphenyl)-1H-pyrazo1-4-y1j-2l-1-tetrazo1-2-yI} rnethybenzonitri1e; 4-(J5-[I -(3,4-dirnethylphenyl)-I H-pyrazol-4-ylj-IH-tetrazol-1-yl}rncthyl)benzonitrile; 4-({ 5-[1 -(3,5-dimethylphenyl)-1 II-pyrazol-4-yl]-211-tetrazol-2-yl}methyl)benzonitrile; 4-({ 5-[1-(3.5-dirnethylphenyl)-] H-pyrazol-4-yl]-1 H-tetrazo!-1 -yl}rnethyi)benzonitrile; 4-({5-[1-(2-ethylphenyi)-H-pyrazo1-4-yl]-2H-tetrazoI-2-y1}methy) henzonitri1e; 4-({5-[1-(2-ethylphenyl)-11-1-pyrazol-4-ylj-1H-telrazol-1-yl}methyl) benzonitrile; 4-({5-[1-(4-ethyipheny-1 H-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)henzonitrile; 4-({5-[1 -(4-ethy1pheny)-1II-pyrazol-4-yl]-1II-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[1-(4-rnethoxyphenyl)-1 H-pyrazol-4-yl]-2H-tctrazol-2-yl}methyl)henzonitrile; 4-Os-LI -(4-mcthoxyphenyl)-1 I-T-pyrazol-4-yI]-1 I-I-tetrazokl-yl}methyl)benzonitrile; 4-({5-{1-(2-methy1pheny1)-1H-pyrazo1-4-y1]-2H-tetrazo1-2-y1}rnethy) benzonitrile; 4-5-1 -(2-rnethylphenyl)-I H-pyrazol-4-ylj-I H-tetrazol-1 -yl}rnethyl)benzonitrile; 4-( { 5-1 -(4-methyiphenyl)-1 H-pyrazol-4-yl] -211-tetrazol-2-yl}methyl)henzonitrile; 4-({ 5-[1 -(4-methylpheny!)-I H-pyrazol-4-ylj-11-I-tetrazol-1 -yl}rnethyl)benzonitzile; 4-{[5-(5-chloro-1 -methyl-1II-pyrazol-4-yI)-2H-tetrazol-2-yI]methyl}benzonitrile; 4-{[5-(5-ehloro-I -niethyl-1H-pyrazol-4-yl)-1H-tetrazol-1-yl]rnethyl}benzonitrile: 4-{ [5-(5-chloro-1-ethyl-I T-1-pyrazol-4-yl)-2H-tetrazol-2-yl]rnethyl}benzonitrile; 4-{[5-(5-chloro-1-elhyl-1H-pyrazol-4-yI)-III-tctrazol-1-yl]rnethy[} benzonitrile; 4-({5-[5-chloro-1-(2-mcthylpropyl)-IH-pyrazol-4-yI]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({S-[5-chloro-1 -(2-methyipropyl)-I!-I-pyrazol-4-yl]-1I-I-tetrazol-1-yl} methyl)benzonitrile; 4-{ [5-0 -henzyl-5-cliloro-1I-I-pyrazol-4-yI)-2F1-tetrazol-2-yl]methyl} benzonitrile; 4-{[5-@ -benzyl-5-cliloro-1 H-pyrazol-4-yl)-IH-tetrazol-1-yl]methyl}benzonitrile; 4-( [5-(5-chloro-1 -phenyl-I I-T-pyrazol-4-yI)-2H-tctrazol-2-yl]methyl} benzonitrile; 4-{[5-(5-ehloro-1-phenyl-1H-pyrazol-4-yl)-1II-tetrazol-1 -yl]methyl}henzonitrile; 4-({5-[5-ehloro-I -(2-ehlorophenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({ 5-[5-chloro-1 -(2-ehiorophenyl)-1I-I-pyrazol-4-yl]-1 11-tetrazol-1-yl}methyl)henzonitri Ic; 4-( { 5-[5-chloro-1 -(3 -chiorophenyl)-1II-pyrazol-4-yfl-2F1-tetrazol-2-yl} rnethyl)benzonilrile; 4-({5-[5-chloro-1 -(3-chlorophenyl)-1 H-pyrazol-4-ylj-1 H-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[5-chloro-1 -(4-ehlorophenyl)-] H-pyrazol-4-yl]-211-tetrazol-2-yl} rnethyl)henzonitrile; 4-({5-[5-chloro-1-(4-chlorophenyl)-1iI-pyrazol-4-yl]-1H-tetrazol-1-yl} rnethyl)henzonitrile; 4-({S-[5-chloro-1 -(2,3-dichlorophenyl)-1 T-T-pyrazol-4-yl]-2H-tctrazol-2-yl} rnethyl)benzonitrile; 4-({S-[5-chloro-1 -(2,3-dichloropheny[)-1 H-pyrazol-4-yl]-1 I-I-tetrazol-1-yl}niethyl)benzonitrile; 4-({5-[5-chloro-1 -(2,4-dichlorophcnyl)-I H-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-U 5-[5-ehloro-1 -(2,4-dichlorophenyl)-I H-pyrazol-4-ylJ-1 Il-tetrazoh 1-yl}methyl)benzonitrile; 4-U5-[5-ehloro-1 -(2,5-dichlorophenyl)-1I-I-pyrazol-4-ylJ-2H-tetrazol-2-yl} methyl) he nzonitri Ic; S 4-({ 5-[5-chloro-1 -(2,5-diclilorophenyl)-I 1-T-pyrazol-4-yl]-I H-tetrazol-1-yl}nicthyl)benzonitrile; 4-({5-[5-chloro-l -(2,6-diehloropheny1)-1Hpyrazo1-4-y1]-2H-tetrazo1-2-yl}nicthyl) bcnzonitrile; 4-U 5-15-chioro-1 -(2,6-dichlorophenyl)-1H-pyrazol-4-yl]-1 II-tetrazol-1-yl}rnethyl)benzonilrile; 4-U 5-[5 -cli loro-1 -(3,4-dich1oropheny-11 I-pyrazol-4-yl] -2H-tctrazol-2-yl} metliyl)benzonitrilc; 4-({5-[5-chloro-1-(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-IH-tetrazol-I -yl} methyl)bcnzonitrilc; 4-U5-15-chloro-1-(3,5-dichlorophenyl)-1 H-pyrazol-4-yl]-2F1-tetrazol-2-yE}methyl)benzonitrile; 4-({5-[5-chloro-1-(3,5-dichlorophenyl)-1IT-pyrazol-4-yl]-IH-tetrazol-1 -yl}methyE)henzonitri Ic; 4-U5-[5-chioro-1 -(2-brornophenyl)-1 H-pyrazol-4-yll -211-tetrazol-2-yl}methyl)henzonitri!e; 4-({5-[5-chloro-1 -(2-hromophenyl)-1 H-pyrazol-4-ylj-IH-tetrazol-1-Yl} methyl)benzoniirile; 4-({5-[5-chloro-1-(3-brornophenyl)-III-pyrazol-4-yl]-2H-tetrazol-2-vl} methyl)benzonitrilc; 4-({5-[5-chloro-1 -(3-bromophenyl)-lFl-pyrazol-4-y!]-IH-tetrazol-l -yl} mcthyl)henzonitri Ic; 4-({5-[5-chloro-1 -(4-bromophcnyl)-IFI-pyrazol-4-yI]-2H-tetrazol-2-yl}nethyDbenzonitnle; 4-U5-15-chloro-1 -(4-bromophenyl)-1 H-pyrazol-4-yl]-1H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-chloro-i-(4-fluorophenyl)-11-l-pyrazol-4-vl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({ 5-[5 -chioro-1 -(4-fluorophenyl)-1 1-I-pyrazol-4-ylJ-I 1-1-tetrazo I-I -yI}methyl)henzonitrile; 4-({5-[5-ehloro-i -(2-fluoropheny)-1H-pyrazo1-4-y1]-211-tetrazoI-2-yl}methyl)benzonitrile; 4-({5-[5-ehloro-1 -(2-fiuoropheny)-1H-pyrazo1-4-yl}-1 H-tetrazol-i-y} niethyl)benzonitrile; 4-eis-[s-ehloro--(2,3-dimethylphenyl)-1II-pyrazol-4-yTj-2H-tetrazol-2-yl} rnet.hyl)benzonitrile; 4-({5-[5-eNoro-1-(2.3-dimethylphenyl)-1 H-pyrazol-4-yl]-1H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-chloro-1 -(2,4-dimethyiphenyl)-1 FJ-pyrazo1-4-y1-2H-tetrazo1-2-yl}rnethyl)benzonitri Ic; -N 5-[5-chloro-1 -(2,4-dimethy1pheny-1 H-pyTazol-4-yl]-1 H-tctrazol-1 -yl} methyl) henzoni true; 4-({5-[5-chloro-I -(2,5-dirnethypheny1)-1II-pyrazo1-4-v1]-2H-tetrazoI-2-yl}methyi) benzonitrile; 4-({5-[5-ehloro-1 -(2.5-dimethylphenyl)-1 H-pyrazol-4-yl]-IH-tetrazol-1-yl}rnethyl)henzonitrile; 4-( { 5-[5 -ehioro-1 -(2,6-dimethypheny1)-1 H-pyrazol-4-yl] -211-tetrazol -2-y}methyl)henzonitrile; 4-({5-[5-ehloro-1 -(2,6-dimethy1phcny1)1 H-pyrazol-4-yl]-1H-tetrazol-1-y} methyl)benzonitrile; 4-({5-[5-ehloro-1-(3,4-dirnethylphenyl)-1 1-I-pyrazol-4-yl}-2H-tetrazol-2-yl}methyl)benzonitrile; 4-(j5-[5-chloro-1-(3,4-dimethv!phenyl) -1T-I-pyrazol-4-yll-1II-tetrazol-1-yI} rnethyl)benzonitrile; 4-({5-[5-chloro-1-(3,5-dirnethvlphenvl)-1IJ-pyrazol-4-yl] -2H-tetrazol-2-yl} rnethyl)benzonitrile; 4-({5-[5-chloro-1 -(3.5-dimeU vlphenyl)-1II-pyrazol-4-yl]-1H-tetrazol-1 -yl} methyl)benzonitrile; 4-( { 5-[5-chloro-1 -(2-ethylphenyl)-1 II-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[5-chloro-I -(2-ethylphenyl)-1H-pyrazol-4-yll-1I1-tetrazot-. I -yI)methyl)benzonitrile; 4-({5-[5-chloro-1 -(4-ethylphenyl)-] H-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-[5-ehloro-I -(4-ethyiphenyl)-1H-pyrazol-4-yll-1 1-1-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[5-chloro-1-(4-methoxyphenyl)-IH-pyrazol-4-yl]-211-tetrazol-2-yl} rnethyl)benzonitrile; 4-({5-[5-chloro-1-(4-rnethoxyphenyl)-1H-pyrazo!-4-ylJ-I H-tetrazo]-1 -yl}methyl)benzonitrile; 4-({5-[5-chloro-1-(2-methylphenyl)-1 H-pyrazo]-4-y1j2H-tetrazo1-2-yl}rnethyl)benzonitrile; 4-({5-[5-chloro-l -(2-methylphenyl)-1 H-pyrazol-4-ylJ-1H-tetrazol-l-yl}methyl)benzonitrile; 4-({5-[5-ehioro-I -(4-methyiphenyl)-1 H-pyrazol-4-yl] -2H-tctrazol-2-yl}methyl)benzonitrile; 4-({5-[5-ehloro-I -(4-methylphenyl)-1 II-pyrazol-4-yl]-1 H-tctrazol-1 -yl}methyl)benzonitrile; 4-{[5-(-bromo-l-rnethy1-lII-pyrazol-4-yl)-2H-tetrazol-2-yl]rnethyl} benzonitri1e; 4-{[5-(5-bromo-1 -methyl-I H-pyraco]-4-y1)-1H-tetrazol-1-ymethy1}henzonitrilc; 4-{[5-(5-bromo-1 -ethyl-l H-pyrazoI-4-y-2H-telrazol-2-y1jrnethy1}benzonitrile; 4-{[5-(5-bromo-l-ethyl-1H-pyrazol-4-yl)-1II-tetrazol-1 -yI]methyl}benzonitrile; 4-(5-[5-brorno-I -(2-methylpropyl)-1 H-pyrazol-4-yfl-211-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[5-bromo-l-(2-methylpropyl)-1II-pyrazol-4-yl]-1H-tetrazol-I -yl} methyl) benzonitrile; 4-{[5-(1-benzyl-5-bromo-1H-pyrazol-4-yl)-21-T-tetrazol-2-yI]niethyl} benzonitrile; 4-{[5-(1-benzyl-5-bromo-1iI-pyrazol-4-yl)-1H-tetrazol-1 -yllrnethyQhenzonitrile; 4-{ [5-(5-brorno-I -phenyl-IH-pyrazol-4-yl)-211-teirazol-2-yl]methyl}benzonitrile; 4-{[5-(5-bromo-1-phcnyl-1H-pyrazol-4-yl)-l H-tetrazol-I -yljmethyl}benzonitrile; 4-({ 5-L5 -bromo-1 -(2-chiorophenyl)-I H-pyrazol-4-yl] -2H-tctrazol-2-yl} methyl)bcnzonitrilc; 4-({ 5-[5-bromo-1 -(2-ehlorophenyl)-IH-pyrazol-4-yl]-lH-tetrazo!-1 -yl} methyl)henzonitn Le; 4-({5-[5-hromo-1 -(3-ehlorophcnyl)-lH-pyrazol-4-yl]-2H-telrazol-2-yl} rnethyl)benzonitrile; 4-({5-[5-hromo-I -(3-ehlorophenyl)-1H-pyrazol-4-yl]-1H-telrazol-1 -yl}rnethyl)benzonitrile; 4-({5-[5-bromo-1-(4-chlorophenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-bromo-1 -(4-eh]orophenyl)-III-pyrazol-4-yl]-ITi-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-bromo-1 -(2,3-dichlorophenyl)-1 I-T-pyrazol-4-yl]-211-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-brorno-I -( ,3-dichlorophenyl)-1iI-pyrazol-4-yl]-1 1-1-tetrazol-1-yl}methyl)benzonitri Ic; 4-(5-5-brorno-1 -(2,4-dichlorophenyl)-1ll-pyrazol-4-yij-2H-tetrazol-2-yl}rnethyl) bcnzonitrile; 4-G5-[5-bromo-I -(2,4-diehiorophenyl)-IH-pyrazol-4-yfl-1H-tetrazol-1 -y} rnethvl)benzoni Lii c; 4-( { 5-[5 -bromo-1 -(2,5-dicfflorophenyl)-] H-pyrazol-4-yl] -21 I-tetrazol-2-yl}methyl)benzoniti-ile; 4-({5-[5-brorno-I -(2,5-diehlorophenyl)-1I-I-pyrazol-4-yl]-1H-tctrazol-1-y1}rnethyl) benzonitrfle; 4-({5-[5-brorno-1 -(2,6-dichlorophenyl)-1 H-pyrazol-4-yl]-2H-tetrazol-2-yl} methyl)benzonitrilc; 4-({5-[5-bromo-1-(2,6-diehlorophenyl)-IH-pvrazol-4-yl]-1 H-tetrazol-1-yl} mcthyl)benzonitri Ic; 4-({5-[S-hromo-1 -(3,4-diehlorophenyl)-1H-pyrazol-4-yl]-211-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[5-brorno-1-(3,4-dichlorophenyl)-1I-I-pvrazol-4-yl]-IH-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[5-bromo-1-(3,5-diehlorophenyl)-1 H-pyrazoh4-ylj-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-bromo-1 -(3,5-dichlorophenyl)-1 H-pyrazol-4-yl]-1II-tetrazol-1-yl} methyl)benzonitrile; 4-( {5-[5-brorno--(2-brornophenyl)-1I1-pyrazol-4-yl]-2H-tctrazol-2-yl} methyl)benzonitrilc; 4-({5-[5-bromo-1-(2-bromophenyl)-1H-pvrazol-4-yl]-IH-tetrazol-1-yl} mcthyl)henzonitri Ic; 4-({ 5-[5-brorno-1 -(3-bromophenyl)-I H-pyrazol-4-yl]-2H-tetrazol-2-yl}n-iethyl)benzonitrile; 4-({5-[5-hromo-I --broniophenyl)-IH-pyrazol-4-ylj-1H-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[5-bromo-1-(4-bromophenyl)-1H-pyrazol-4-yfl-211-tetrazol-2-yl} methyl)benzonitrile; 4-({ 5-[5-bromo--(4-bromophenyl)-IH-pyrazol-4-yl]-1II-tetrazol-1-yl} methyl)benzonitri le; 4-( { 5-[5 -brorno-1 -(4-Iluorophenyl)-1 H-pyrazol-4-yfl-21 1-tetrazol -2-yl}methyl)benzonitriie; 4-({ 5-[5-brorno-1-(4-fluorophenyl)-I H-pyrazol-4-yl]-H-tctrazol-1 -yl} methyl)benzonitrile; 4-({5-[5-bromo--(2-fluorophenyl)-W-pyrazol-4-yl]-211-tetrazol-2-yl} rnethyl)benzonitrile; 4-({5-[5-bromo-1-(2-fluoropheny-1 H-pyrazol-4-yI]-1H-tetrazol-1-yl}rneihyl)benzonitrile; 4-({5-[5-brorno--(2,3-diniethy1pheny1)-1I-I-pyrazo1-4-y1-2H-tetrazo1-2-yl} methyl)benzonitrile; 4-({5-[5-hromo-I -(2,3-dirnethylphenyl)-1II-pyrazol-4-yll-1H-tetraz&-1 -yl}methyl)henzonitrile; 4-({5-[5-brorno-1-(2.4-climethylphenyl)-I H-pyrazol-4-ylj-2}-I-tetrazol-2-yl} rnethyl)benzonitrile; 4-( {5-[5-bromo-1 -(2,4-dimethylphenyl)-1H-pvrazol-4-ylI-1FI-tetrazol-1 -yl} methyl)benzonitrile; 4-({5-[5-bromo-1-(2.5-dirnethylphenyl)-1H-pyrazol-4-ylI-21I-tetrazol-2-yl} mcthyl)benzonitrile; 4-({5-[5-bromo-1-(2.5-dimcthylphenyl)-1H-pyrazo!-4-yl]-1 H-tetrazol--yl} rnethyl)benzonitrile; 4-({5-[5-bromo--(26-dirnetliylphenyl)-I I-I-pyrazoi-4-ylj-2H-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[5-bronio--(2,6-diniethylphenvl) -II-I-pyrazol-4-vll-1II-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[5-bromo-1-(3.4-dirnethV1pheny1)-lT-I-pyrazo1-4-y1-2H-tetrazo1-2-yl} methyl)benzonitrile; 4-({5-[5-brorno-1-(3,4-dimethylphenyl)-l 1-{-pyrazol-4-yfl-1 H-tetrazoi-1-yl} rnethyl)benzonitrile; 4-({5-[5-bromo-I -(3,5-dimethy1pheny)-1H-pyrazo1-4-y1j-2H-tetrazo1-2-yl}methyl) benzonitrile; 4-({5-[5-brorno-1-(3,5-dirnethy1pheny)-1H-pyrazo1-4-y1-1H-tetrazo1-1-yl} methyl)benzonitrile; 4-({ 5-[5-brorno-1 -(2-ethylphenyI)-lJ-pyrazo!-4-yl]-2H-tetrazol-2-yi}methyl)benzonitrile; 4-({5-[5-bromo-1-(2-ethylphenyl)-1II-pyrazol-4-yfl-1II-tetrazol-1-yI} methvl)henzonitrile; 4-({5-[5-bromo-I -(4-ethylphenyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-[5-brorno-1-(4-ethylphenyI)-I-T-pyrazol-4-yl]-1 H-tetrazol-I -yl}methyl)benzonitrile; 4-( { 5-[5-bromo-1 -(4methoxypheny1)-1 H-pyrazol-4-ylJ-2H-tetrazol-2-yl}methybenzonitri1e; 4-( { 5-[5-bromo-1 -(4-methoxyphenyl)-1 H-pyrazol-4-ylJ-I fl-tetrazo I-I -yl) methyl)bcnzonitrile; 4-( { 5-[5 -bromo-I -(2-methyiphenyl)-1 F1-pyrazol-4-yfl-2H-tetrazol-2-yl}methy!)benzonitri Ic; 4-({5-[5-bromo-1-(2-methylphenyl)-1H-pyrazol-4-ylj-IH-tetrazoi-1 -yl}niethyl)ben'zonitrile; 4-({5-[5-brorno-1-(2-rnethylphenyl)-1 H-pyrazoi-4-y!]-21-t-tetrazol-2-yl}rnethyl) benzonitrile; 4-( { 5-[5-bromo-1 -(2-methyiphenyl)-I 1-T-pyrazol -4-yl] -I 1-1-tetrazol -1 -yl} methyl) benzonitrile; 4-{ [5-(5-iodo-1-methyl-i 1-l-pvrazol-4-yl)-2H-tetrazol-2-yljmethyl}benzonitrile; 4-{[5-(5-iodo-1-rnethy1-1II-pyrazol-4-y1)-1H-tetrazol-I-yl]methy} benzonitrile; 4-{[5-(i -ethyl-5-iodo-1H-pyrazol-4-yl)-2H-tetrazol-2-yljmethyl}beitwnitrile; 4-{[S-(1-ethyk5-iodo-1II-pyrazo!-4-yI)-I I-T-tetrazo!-I -yflmethyl}benzonitrile; 4-({5-[5-iodo-1-(2-mcthylpropyl)-IH-pyrazol-4-yl]-2H-tetrazol-2-yI} niethyl) henzonitrile; 4-S-[5-iodo-1-(2-rnethylpropy1)-lIi-pyrazol-4-y1]-1II-tetrazol-1-y1} inethyl) benzonitrile; 4-{[5-(I -benzyi-5-iodo-1 H-pyrazol-4-yI)-2H-teirazol-2-yl]rnethyl}benzonitrile; 4-{[5-(l-benzyl-5-iodo-1TI-pyrazol-4-yl)-1H-tetrazol-1 -yllmethyl}benzonitrile; 4-{[5-(5-iodo-l -phenyi-I I-l-pyrazol-4-yI)-2H-tetrazol-2-yl]methyl}benzonitrile; 4-{ [5-(5-iodo-1-phenyl-1H-pyrazol-4-yl)-1H-tetrazol-1-yl]methyl} bcnzonitrile; 4-({5-[1-(2-ehlorophenyl)-5-iodo-IH-pyrazol-4-yl]-21-I-tetrazol-2-yl} methyl)bcnzonitrile; 4-({5-{l-(2-eh1oropheny)-5-iodo-1H-pyrazo1-4-yfl-1II-tetrazol-l -yl}methyl)benzonitrile; 4-({5-[1-(3-ehlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2H-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[1 -(3-ehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1I-I-tetrazol-1-yl}methyl) benzonitrile; 4-05-LI -(4-ehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2F1-tetrazol-2-yl}niethyl) benzonitrile; 4-({5-[1-(4-chlorophenyl)-5-iodo-1II-pyrazol-4-yll-1I-1-tetrazol-1 -yl}methyl)benzonitrile; 4-({5-[1-(2,3-diehlorophenyl)-5-iodo-1H-pyrazol-4-ylI-2H-tctrazol-2-yl} methyl) benzonitrile; 4-({5-[1 -(2,3-dichlorophenyl)-5-iodo-1I-I-pyrazol-4-yfl-1H-tetrazol-1-yl}methyl) benzonitrile; 4-({5-[1-(2,4-dichlorophenyl)-5-iodo-1 H-pyrazoi-4-ylj-21-I-tetrazol-2-yl}methyl)henzonitrile; 4-({5-[1-(2.4-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-1H-tetrazol-1 -yl} nicthyl)benzonitrile; 4-({5-[1-(2.5-dichlorophcny1)54odo-1H-pyrazo1-4-yfl-2J-J-tetrazcil-2-yl} rnethyl)henzonitrile; 4-5-[1 -(2,5-dich1orophenyl)-5-iodo-1H-pyrazo1-4-y1-1JJ-tctrazo1-1 -yl}methy])benzonitrile; 4-({5-[1-(2,6-dich1oropheny1)-5-iodo-1II-pyrazo1-4-y1-2H-tetrazc1-2-rI} methyl)benzonitrile; 4-({5-{1 -(2,6-dichlorophenyl)-5-ioclo-IH-pyrazol-4-yIJ-H-letrazol-1-yl}methyl) bcnzonitri le; 4-({5-{1 -(3,4-dichloropheny!)-5-iodo-I H-pyrazo1-4-y1-2II-tetrazo1-2-yl}rnethyl)benzonitrile; 4-({5-[1 -(3,4-dichlorophenyl)-5-iodo-1iI-pyrazol-4-yl]-IT-Ltetrazol-l-yl}methyl) benzonitrile; 4-({5-[1-(3,5-dieh1oropheny1)-5-iocIo-1TT-pyrazoI-4-yI]-2H-tetrazoh2 y!}methyl)benzonitrile; 4-({S-[1 -(3.5-dichlorophenyl)-5-iodo-IH-pyrazol-4-yl]-1H-tetrazol-1-yl} rnethyl)benzonitrile; 4-({5-[ -(2-hroniophenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}rnethyl) benzonitrile; 4-({5-{1-(2-bromophenyl)-5-iodo-IH-pyrazol-4-yI]-1 H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[1-(3-bromophenyl)-5-iodo-1H-pyrazoh4-yI]-2H-tetrazol-2-ylyme.thyl) benzonitrile; 4-({5-[1-(3-bromophenYl)-5-iodo-11-I-pyrazok4-yll-1JJ-tetrazol-1-yl} methyl)benzonftrile; 4-({5-[1-(4-brornophcny!)-5-iodo-H-pyrazol-4-ylj-2H-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[1-(4-bromophenyl)-5-iodo-1R-pyraz&-4-vl]-IH-tetrazol-I -yl}niethyl)benzonitrile; 4-({5-[1 -(4-fluorophenyl)-5-iodo-1H-pyrazol-4-ylj-21-I-tetrazol-2-yl}methyl) berzonitri]e; 4-({5-[1-(4-fluorophenyl)-5-iodo-1iI-pyrazoh4-yI]-I FT-tetrazol-1-yl}rnethyl)benzonitrHe; 4-({5-[I-(2-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-211-tetrazol-2-yI} methyl)benzonj(rjle; 4-({5-[1-(2-fluorophenyl)-5-iodo-1 H-pyrazol-4-yl]-1H-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[1-(2.3-dimethylphenyl)-5-iodo-1iI-pvrazol-4-vl]-21-J-tetrazol-2-yl} methyl)benzonitri Ic; 4-({5-[1 -(2,3-dirnethylphenyl)-5-iodo-1H-pyrazcd-4-yl]-1I-I-tetrazol-I -yl} rnethyl)benzonitri le; -({5-I) -(2,4-dimethylphenyl)-5-iodo-1II-pyrazol-4-yl]-2H-tetrazol-2-yl}methyl) benzonitrile; 4-({5-[1-(2,4-dimethylphenyl)-5-iodo-1 H-pyrazol-4-ylj-IH-tetrazol-1-yl}niethyl)benzonitrile; 4-({5-[1-(2,5-dirnethylpbenyl)-5-iodo-IH-pyrazol-4-yl]-211-tetrazol-2-yl} rncthyl)benzonitrile; 4-({5-[1 -(2,5-dimethylphcnyl)-3-iodo-1 H-pyrazol-4-yJj-1H-tetrazol-1-yl}rnethyl)benzonitrile; 4-( {5-[1 -(2,6-dimethyIpheny)-5-iodo-IH-pyrazol-4-yl]-211-tetrazol-2-yl} methyl)benzonitrile; 4-({5-[ -(2,6-dirnethy1pheny1)-5-iodo-lH-pyrazo1-4-y]-1 H-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[1-(3,4-dimethylpheny!)-5-iodo-1 H-pyrazol-4-yfl-2J-I-tetrazol-2-yl} rnethyl)benzonitrile; 4-((5-[] -(3,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yf]-1H-tetrazol-1-yl} methyl)benzonitrile; 4-({5-[1-(3,5-dirnethy1pheny1)-5-iodo-1}I-pyrazo1-4-y1-2II-tetrazo1-2-yl} methyl)benzonitrile; 4-G5-[1 -(3,5-dimethylphenyl)-5-iodo-1H-pyrazo!-4-yl]-1 H-tetrazoI--yl}methyl)benzonitrile; 4-((5-[1 -(2-ethylphenyl)-5-iodo-1 H-pyrazoi-4-yl]-2H-tetrazol-2-yl}rnethyl)benzonitrile; 4-({5-[1-(2-ethylphenyl)-5-iodo-IH-pyrazol-4-yl]-IH-tetrazol-1 -yI)methyl)benzonitrile; 4-({5-[1 -(4-ethylphenyl)-5-iodo-1II-pvrazol-4-yll-211-tetrazol-2-y1)methyl) benzonitrile; 4-({5-[1-(4-cthy1pheny-5-iodo-1 H-pyrazol-4-yI]-H-tetrazol-1-yl}methyl)benzonitrile; 4-({5-[5-iodo-1 -(4-methoxyphcny)-1 H-pyraz&-4-yl]-2H-tetrazol-2-yl}melhyl)benzonitrile; 4-({3-[5-iodo-1 -(4-methoxyphenyl)-1 H-pyraz&-4-yl]-1 H-tetrazol-1-yl}rnethyl)benzonitrile; 4-({5-[5-iodo-1 (2-rnethy1pheny1)-1 H-pyrazol-4-ylJ-2H-tetrazol-2-yl}methyl)benzonitrile; 4-({5-[5-iodo-1-(2-methy1phenyI)-H-pyrazol-4-yl]-I H-tetrazol-I -yl}rnethyl)benzonitrile; 4-({5-[5-iodo-1 -(4-meihylphenyl)-1 H-pyrazol-4-yl]-21-I-tetrazol-2-yl}mcthyl)bcnzonitrile; 4-( {3-[5-iodo-1 -(4-methylphenyl)d H-pyrazol-4-yI]-I H-tetrazol-] -yl}methyl)benzonitrile; 2-(4-methoxybcnzyl)-5-(I -methyl-1 H-pyrazol-4-yl)-2H-tetrazole; 1 -(4-rnethoxybenzyl)-5-(l -methyl-1 I-l-pyrazoi-4-yl)-2H-tetrazole; 5-(1-ethy1-1H-pyTazoI-4-y1)-2-(4-methoxyhenzy-2H-teUazoIe; 5-(1-ethyI-1H-pyrazo1-4-y1)-1-(4-rncthoxybenzy-2H-tetrazoIe; 2-(4-rnethoxybenzyl)-5-[1 -(2-methylpropyl)-l I I-pyrazol-4-yfl-211-tetrazoie; 2-(4-methoxybenzyl)-5-[l -(2-rnethylpropyl)-l H-pyrazol-4-yl]-2H-tetrazoie; 5-( 1 -benzyl-1 iI-pyrazol-4-yl)-2-(4-methoxyhenzyi)-2H-tetrazole; 5-(1 -henzyl-1 H-pyrazol-4-yI)-I -(4-niethoxybenzyl)-2T-T-tctrazolc; 2-(4-rnethoxybenzyl)-5-(1 -phenyl-11 I-pyrazoi-4-yl)-211-tetrazoie; 1-(4-methoxybenzyl)-5-(j-phenyl-1H-pyrazoi-4-yl)-211-telrazoie; 5-11 -(2-chlorophenyl)-lI-I-pyrazol-4-yI]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-Li -(2-ehlorophenyl)-1 IT-pyrazol-4-yl]-l -(4-methoxybenzyl)-2H-tetrazole; 5-[I -(3-chiorophenyl)-I H-pyrazol-4-yl]-2-(4-methoxybenzyl)-211-tetrazole; 5-[l -(3-chlorophcnyl)-I H-pyrazoi-4-yl]-I -(-rnethoxyhenzyl)-2H-tetrazole; 5-[1 -(4-chlorophenyl)-I H-pyrazoi-4-yl]-2-(4-mcthoxybcnzyl)-2H-tetrazolc; 5-[I -(4-chloropheriyl)-I I-l-pyrazoi-4-ylj-1-(4-methoxybenzyl)-21-1-tetrazole; 5-[1 -(2.3-dichlorophenyl)-1 H-pvrazol-4-yl]-2-(4-nielhoxybeiizyl)-2H-tetrazole; 5-[l -(2,3-dichlorophenyl)-I H-pvrazol-4-yll-1 -(4-nicthoxyhcnzyl)-2H-tctrazolc; 5-Li -(2,4-dichlorophenyi)-l H-pyrazol-4-ylj-2-(4-rnethoxybenzyi)-2H-tetrazole; 5-[i -(2,4-dichloropheny[)-I H-pyrazol-4-yl]-l -(4-rncthoxybcnzyl)-2H-tctrazolc; 5-[l -(2,5-dichiorophenyl)-lII-pyrazoi-4-y1-2-(4-methoxybenzyl)-2H-tetrazo1e; 5-{i -(2,5-dichlorophenyl)-lH-pyrazol-4-yl]-1-(4-rnethoxybenzyl)-2H-tetrazole; 5-[I -(2.6-dichiorophenyt)-H-pyrazol-4-ylj-2-(4-nicthoxybcnzyl)-2H-tetrazo]e; 5-[i -(2,6-dichIorophenyl)-1 H-pyrazol-4-yl]-1-(4-methoxybcnzyl)-211-tctrazolc; 5-Li -(3,4-dichlorophenyl)-1 H-pyrazo1-4-y1]-2-(-rnethoxybenzy1)-2Ii-tetrazole; 5-1l-(3,4-dichlorophcnyl)-1H-pyrazol-4-yl]-1 -(4-methoxyhenzyl)-2H-tetrazole; 5-Li -(3,5-dichiorophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyi)-2H-tctrazoic; 5-LI -(3,5-dichiorophenyl)-IH-pyrazol-4-yl]-i-(4-methoxybenzyi)-2F1-tetrazole; 5-[1 -(2-bromophenyi)-1 H-pyrazol-4-yl]-2-(4-mcthoxybcnzyl)-2H-tctrazolc; 5-Li -(2-bromophenyl)-1 H-pyrazol-4-yij-1 -(4-methoxybenzyi)-2H-tetrazole; 5-[i -(3-brornophenyl)-1H-pyrazol-4-yi]-2-(4-methoxybenzyi)-2H-tetrazole; 5-[1 -(3 -bromophenyl)-1 I-I-pyrazol-4-yl] -1 -(4-methoxybenzyl)-2H-tetrazole; 541 -(4-bromophenyi)-1 H-pyrazol-4-ylj -2-(4-methoxybenzyl)-2H-tetrazole; 5-[i-(4-bromophenyl)-1H-pyrazol-4-yI]-1 -(4-methoxyhenzyl)-2H-tctrazole; 541 -(4-fluorophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-21I-tetrazole; 5-[1 -(4-fluorophenyl)-1H-pyrazol-4-yl]-I -(4-rnethoxybenzyl)-2H-tetrazole; 5-[ 1 -(2-fluorophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(2-fluorophenyl)-I I-1-pyrazol-4-ylj -1 -(4-methoxybenzyl)-2F1-tetrazole; 5-[1 -(2,3-dimethylphenyl)-1II-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[ I -(2.3-dirnethylphenyl)-IH-pyrazol-4-yl]-1 -(4-mcthoxybcnzyl)-2H-tetrazole; 5-[1 -(2,4-dimethylphcnyl)-1 1-l-pyrazol-4-yl j-i -(4-rnethoxybenzyl)-211-letrazole; 5-[ 1 -(2,4-dimethylphenyl)-I 1-T-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 541 -(2.5-dimethy1phcny1)-lH-pyrazo1-4-yI]-2-(4-methoxybenzy-2I-l-tetrazo1e: 5-[l -(2,5-dirnethylphenyl)-lI-I-pyrazol-4-yfl-1 -(4-rnethoxybenzyl)-2H-tctrazolc; 5-[1 -(2.6-dirncthylphenyl)-1 H-pyrazol-4-yIj-2-(4-methoxybenzyl)-211-tetrazole; 5-LI -(2.6-dimethyiphenyl)-1 Il-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(3.4-dirnethylphenyl)-1iI-pvrazol-4-yl]-2-(4-methoxvbenzyl)-2H-tctrazole; 5-[ I -(3,4-dinicthylphenyl)-1H-pyrazol-4-ylj-1 -(4-methoxybenzyl)-211-tetrazole; 541 -(3,5-dimethyIpheny-I H-pyrazol-4-ylj-2-(4-rnethoxybenzyl)-2H-tetrazole; 541 -(3.5 -dimethyiphenyl)-1 H-pyrazol-4-yfl-1 -(4-rnethoxybenzyl)-2T-l-tetrazo le; 5-11 -(2-ethyiphenyl)-1 H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(2-ethylphenyl)-1H-pyrazol-4-ylI-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(4-ethyiphenyl)-1 H-pyrazol-4-yfl-2-(4-methoxybenzyl)-211-tetrazolc; 5-[1 -(4-ethylphenyl)-I H-pyrazol-4-ylj-1-(4-methoxybenzyl)-2H-tetrazole; 2-(4-methoxybcnzyl)-5-[1 -(4-methoxyphenyl)-I H-pyrazol-4-yl]-2H-tetrazole; 2-(4-methoxybenzyl)-5-[1-(4-methoxyphenyl)-1H-pyrazol-4-yl]-2H-tctrazolc; 2-(4-niethoxyhenzyl)-5-[I -(2-methylphenyl)-1H-pyrazol-4-yl]-211-tetrazole; 1 -(4-methoxybenzyl)-5-[1 -(2-methylphenyl)-1 H-pyrazol-4-yl]-2H-tetrazole; 2-(4-methoxybenzyl)-54 1 -(4-methylphenyl)-1II-pyrazol-4-yfl-211-tetrazole; 1-(4-methoxybcnzy1)-5-[l-(-methy1phenyI)-1 T-i-pyrazol-4-yl]-21-1-teixazole; 5-(5-ehloro-1 -methyl-I H-pyrazol-4-yI)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(5-chloro-1 -methyl-IH-pyrazol-4-yl)-1 -(4-methoxybenzy-2fl-tetrazo1e; 5-(5-chloro-l -ethyl-I H-pyrazol-4-yI)-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-(5-chloro-1 -ethyl-i H-pyrazol-4-yl)-I -(4-methoxybenzyl)-211-tetrazole; 545-ehloro-1 -(2-methyipropyl)-1H-pyrazo1-4-y1-2-(4-methoxybenzyl)-2H-tetrazo1e; 5-[5-chloro-1 -(2-methyipropyl)-I 1T-pyrazol-4-yl]-1 -(4-methoxyhenzyl)-2H-tetrazole; 5-(1-benzyl-5-chloro-1H-pyrazol-4-yl)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(1 -benzy!-5-ehloro-1IT-pyrazol-4-yl)-1-(4-methoxyhenzyl)-2H-tetrazole; 5-(5-chloro-1 -phenyl-1H-pyrazol-4-yl)-2-(4-rnethoxyhenzyl)-21-I-tetrazole; 5-(5-eh]oro-1 -phenyl-IH-pyrazol-4-yl)-l -(4-methoxybenzyl)-2H-tetrazole; 5-[5-ehloro-1-(2-chlorophenyl)-1I-1-pyrazol-4-yl]-2-(4-methoxybcnzyl) -2H-tctrazo]e; 5-[5-ehloro-1 42-chlorophenyl)-1T-l-pyTazol-4-yl]-l -(4-methoxybenzyi)-21-l-tetrazole; 5-[5-chloro-1 -(3-chlorophenyl)-H-pyrazo1-4-y1]-2-(-methoxybenzy1)-2H-tetrazo1e; 5-[5-chloro-1 -(3-chiorophenyl)-I T-l-pyrazol-4-yl]-I -(4-methoxybenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-chlorophenyl)-lIi-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tctrazolc; 5-[5-chloro-1 -(4-chiorophenyl)-1H-pyrazol-4-yl]-1 -(4-methoxybcnzyl)-21-l-tctraz6le; 5-[5-chloro-1 -(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-methoxybenzyl)-21-1-tetrazole; 5-[5-chloro-1-(2.3-dichlorophenyl)-1H-pyrazol-4-yl]-I -(4-methoxyhenzyl)-2H-telrazole; 5-[5-chloro-i -(2,4-dichlorophenvl)-1II-pyrazol-4-yfl-2-(4-methoxybenzyl)-2F1-tctrazolc; 5-[5-chloro-1-(2.4-dieh!orophenyl)-I H-pyrazol-4-yI]-I -(4-meG oxybenzyl)-211-tetrazole; 5-[5-chloro-1 5-[5-chloro-1-(2.5-dichlorophenyl)-1H-pyrazol-4-yl]-I -(4-methoxybenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2,6-dichiorophenyl)-1H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2,6-dichlorophenyl)-I H-pyrazol-4-yIj-1 -(4-met]ioxybenzyl)-2H-tetrazole; 5-[5-ch1oro-1-(3,4-dich1orophenyI)-1lI-pyrazo!-4-y1]-2- (4-methoxybenzy-2H-tetrazolc; 5-[5-chloro-1 -(3,4-dichlorophenyl)-1l-I-pyrazol-4-y1]-l-(4-rnethoxybcnzyl) -211-tctrazolc; 5-[5-chloro-1 -(3,5-dichoropheny-1 H-pyrazol-4-yI]-2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-chloro-1-(3,5-dichlorophenyl)-1FI-pyrazol-4-yfl-l-(4-rncthoxybenzyl) -2H-tetrazo!e; 541 -(-bromopheny1)-5-ch1oro-1II-pyrazo1-4-yfl-2-(4-methoxybenzyl) -2H-tetrazo1e; 5-[1-(2-bromophenyl)-5-chloro-IH-pyrazol-4-yI]-I -(4-methoxybenvy-2H-Letrazo1e; 5-[1 -(3-bromophenyl)-5-chloro-1H-pyrazol-4-yl]-2-(4-methoxybcnzyl) -2H-tctrazole; 5-[1 -(3-hromophenyl)-5-chloro-1 H-pyrazol-4-ylj-1 -(4-rnethoxybenzyl)-2H-tetrazole; 5-[1-(4-bromophenyl)-5-chloro-1H-pyrazol-4-yl]-2-(4-rnethoxyhenzyl) -2H-tetrazole; 5-Fl -(4-bromophenyl)-5-chloro-1I1-pyrazol-4-yl]-1 -(4-methoxyhenzy-2T-T-tctrazoIc; 5-F5-chloro-l -(4-fluorophenyl)-11-I-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-15-choro--(4-fluorophenyl)-1 H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2-iluorophenyl)-1 H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-21I-tetrazole; 5-[5-chloro-I -(2-fluorophcnyl)-1H-pyrazol-4-ylj-1-(4-methoxybenzyl)-2H-telrazole; 5-[5-chloro-1 -(2,3-dimethyipheny!)-I ll-pyrazo1-4-yl-2-(4-mcthoxybenzy1)-2H-tetrazo1e; 5-[5-chloro-1 -(2,3-dimethyiphenyl)-1H-pyrazol-4-ylI-1-(4-methoxybcnzyl)-211-tctrazole; 5-[5-chloro-l -(2,4-dimethyiphenyl)-H-pyrazol-4-ylj-2-(4-methoxybenzyl)-21-l-tetrazole; 5-[5-chloro-l -(2,4-dirnethylphenyl)-lH-pyrazol-4-yli-1-(4-mcthoxyhenzyl)-2H-tetrazole; 5-[5-chloro--(2,5-dirnethylphenyl)-1H-pyrazoh4-yl]-2-(4-methoxyhenzyl) -2H-tetrazole; 5-[5-chloro-1 -(2.5-dimethyiphenyl)-I H-pyrazol-4-yfl-1-(4-rnethoxybenzyl)-211-tetrazole; 5-[5-choro-1 -(2,6-dinwthylphenyl)-1II-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-te(razole; 5-[5-chloro-1 -(2,6-dimethy1pheny1)-1H-pyrazo1-4-y1-1-(4-methoxyhenzy1)-2H-tetrazo1e; S 5-[5-chloro-1 -(3,4-dimethyiphenyl)-I H-pyrazol-4-ylj-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-eh]oro-1-(3,4-dirnethylphenyl)-1II-pvrazol-4-yl]-1-(4-methoxybenzyl) -2H-tetrazole; 5-[5-chloro-1 -(3,5-dimethyiphenyl)-H-pyrazol-4-yl]-2-(4-metboxybenzyl)-2H-tctrazolc; 5-[5-chloro-1 -(3,5-dimethy1pheny1)-1FI-pyruzo1-4-v11-1-(4-methoxybenzy-2H-tetrazo1e; 5-[5-chloro-1 -(2-ethylphenyl)-1 H-pyraz&-4-ylJ-2-(4-rnetlioxybenzyl)-2H-tetrazole; 5-[5-chloro-I -(2-ethylphenyl)-1FI-pyrazol-4-yfl-1-(4-methoxyhenzvl)-2H-ieti-azole; 5-[5-ch1oro-1-(4-ethy1pheny-l I-I-pyrazol-4-yfl-2-(4-methoxybenzyl)-2H-tetrazole; 5-L5-chloro-1-(4-ethylphenyl)-1H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-21-I-tetrazole; 5-[5-chloro-I -(4-methoxyphenyl)-1 I-1-pyrazo]-4-yl]-2-(4-rncthoxybenzyl)-21-1-tetrazole; 5-[5-chloro-1 -(4-rnethoxyphenyl)-1H-pyrazol-4-yl]-1-(4-methoxvhenzyl)-2H-tetrazcile; 5-[5-chloro-1 -(2-methyIpheny-I H-pyrazol-4-yl]-2-(4-methoxybenzyl)-21-I-tetrazole; 5-[5-chloro-1 -(2-rnethylphenyl)-1II-pyrazol-4-yI]-I -(4-methoxybenzyl)-2H-tetrazole; 5-[5-chloro-1-(4-rnethylplienyl)-1H-pyrazol-4-yl]-2-(4-methoxyhenzyE) -2H-tetrazole; 5-15-eh1oro-1-(4-rnethyIpheny-l 1-T-pyrazol-4-yl]-1-(4-rnethoxybenzyl)-211-tetrazole; 5-(5-brorno-1-methy1-1H-pvrazo1-4-y)-2-(4-methoxvbenzy-2H-tetrazo1e; 5-(5-bromo-I -methyl-I I-1-pyrazol-4-yl)-1 -(4-rnethoxybenzyl)-21-I-tetrazole; 5-(5-bromo-1-ethy1-1H-pyrazo1-4-y-2-(4-methoxyhenzy1)-2H-tetrazo1e; 5-(5-hromo-1 -ethyl-1I-I-pyrazol-4-yl)-1 -(4-methoxybenzyl)-211-tctrazole: 5-[5-hrorno-I -(2-rnethylpropyl)-1 H-pyrazol-4-yfl-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(2-methylpropyl)-1H-pyrazol-4-ylj-I -(4-methoxybenzyl)-2F1-tetrazole; 5-( 1-benzyl-5-bromo-1I1-pyrazol-4-yl)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(1 -henzy[-5-hromo-I I-I-pyrazol-4-yl)-1-(4-methoxybenzyl)-211-tetrazole; 5-(5-hromo-I -phenyl-H-pyrazol-4-yl)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(5-bromo-1-phenyl-1H-pyrazoL4-yl)-1-(4-methoxyhenzyl)-2H-tetrazole; 5-[5-hromo-1 -(2-ehlorophenyl)-1 H-pyTazoL-4-yl] -2-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(2-cliloropheny!)-I T-1-pyrazol-4-yI]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1 -(3-ehiorophenyl)-1I-I-pyrazoh4-y1]-2-(4-methoxyhenzy-2H-tetrazo1e; 5-[5-bromo-1-(3-chlorophenyl)-1 H-pyrazoL-4-ylj-i-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-chiorophenyl)-1FI-pyrazok4-yll-2-(4-methoxyhenzyl)-2H-tetrazole; 5-15-bromo-1 -(4-chiorophenyl)-1-T-pyrazol-4-ylj-1-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(2,3-dichlorophenyl)-1 H-pyrazoh4-yll-2-(4-rnethoxybenzyl)-211-tetraz&e; 5-[5-bromo--(2,3-dichlorophcny1)1 H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1-(2,4-dichlorophenyl)-1i1-pyrazol-4-yI]-2-(4-methoxyhenzyl) -21i-tetrazole; 5-[5-hromo-1 -(2,4-dichiorophenyl)-1 H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-211-tetrazolc; 5-[5-bromo-1-(2,5-dichlorophenyl)-I-T-pyrazol-4-ylj-2-(4-methoxybenzyl) -2H-ietrazole; 5-15-brorno-1 -(2,5-dichlorophenyl)-1 I-I-pyrazol-4-yl]-1 -(4-mcthoxybcnzyl)-2H-tetrazole; 5-[5-hrorno--(2,6-dichiorophenyl)-] H-pvrazok4-ylj-2-(4-rnethoxybenzyl)-21-I-tetrazole; 5-[5-brorno-1 -(2,6-dichlorophenyl)-1 I1-pyrazol-4-yfl-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1-(3.4-dichlorophenyl)-H-pyrazol-4-yIj-2-(4-methoxybenzyl) -21-i-tetrazole; 5-15-bromo-1-(3,4-dichlorophenyl)-1 H-pyrazol-4-ylI-1 -(4-mcthoxybcnzyl)-2H-tetrazole; 5-[5-hrorno-I -(3.5-dichiorophenyl)-1 1-1-pyrazol-4-yfl-2-(4-methoxybenzyl)-211-tetrazole; 5-[5-hromo-I -(3,5-dichlorophcnyl)-1H-pyrazol-4-yIj-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1-(2-bromophenyl)-1 H-pyrazoI-4-y1]-2-(4-rnethoxybcnzy-2H-tetrazo1c; 5-[5-brorno-1-(2-brornophenyl)-1 H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-211-tetrazole; 5-[5-bromo-I -(3-brornophenyl)-IH-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(3-bromopheny-1 T-I-pyrazol-4-yI]-T -(4-rnethoxyhcnzy[)-2H-tetrazole; 5-[5-bromo-1-(4-bromophenyl)-1II-pyrazol-4-y!]-2-(4-methoxyhenzyl) -21-T-tetrazo!e; 5-[5-bromo-1 -(4-hromophenyl)-1 TT-pyrazo-4-y1]-1 -(4-niethoxyhenzyl)-21-I-tetrazole; 5-[5-bromo-1 -(4-f1uorophcny1)-1H-pyrazo1-4-y11-2-(4-methoxybcnzv)-2H-tetrazo1e; 5-[5-bromo-1 -(4-fluorophenyl)-1I-I-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2]Ei-tetrazole; 5-[5-bromo-1 -(2-fluorophenyl)-1 EI-pyrazol-4-yfl-2-(4-rnethoxybe.nzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-fluorophenyl)-1H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5 -bromo-1 -(2,3 -dimethyiphenyl)-1 H-pyTazol-4-yl]-2-(4-methoxybenzyl)-211-tetrazole; 5-[5-bromo-1 -(2,3-dirncthylphcnyl)-IH-pyrazol-4-yl]-1 -(4-rncthoxyhcnzyl)-2H-tetrazole; 5-[5-bromo-1-(2,4-dimethyphenyI)-fl-pyrazol-4-yl]-2-(4-methoxyhenzyl) -2H-tctrazolc; 5-[5-brorno-1 -(2,4-dimethylphenyl)-1H-pyrazol-4-ylj-1-(4-rnethoxybenzyl)-2H-tetrazole; 5-[S-brorno-1 -(2,5-dirnethyiphenyl)-1R-pyrazol-4-vl]-2-(4-nethoxybenzyl)-2H-tetrazole; 5-[5-bromo-1-(2,5-dimethy!phenyl)-1 H-pyrazo1-4-y!]-1-(4-methoxybenzyfl-2H-tetrazole 5-[5-bromo-1-(2,6-dimethylphenyl)-1R-pyrazol-4-vl]-2-(4-rnethoxybenzyl) -2H-tetrazole; 5-[5-bronio-1 -(2,6-dimethy!phcnyl)-I H-pyrazol-4-yl]-l-(4-methoxybcnzyl)-2H-tctrazok; 5-{5-brorno-1 -(3,4-dimethylphenyl)-1II-pyrazok4-yl]-2-(4-mcthoxybcnzyl)-21T-tctrazole; 5-[5-bromo-I -(3,4-dirnethyiphenyl)-I H-pyrazol-4-ylj--(4-methoxybenzyl)-2H-tetrazole; 5-[5-bromo-l-(3,5-dimcthylphcnyl)-1 H-pyrazok4-yll -2-(4-mcthoxybcnzyl)-2H-tetrazole; 5-[5-bromo-1 -(3,5-dirnethylphenyl)-IH-pyrazol-4-yl]-1-(4-methoxybenzyl)-2f1-tetrazole; 5-[5-brorno-1-(2-ethy1pheny1)-1H-pyrazo1-4-y1j-2-(4-mcthoxybenzy) -2H-tetrazo1e; 5-[5-hromo-1 -(2-ethylphenyl)-1 i-J-pyrazol-4-yll-i-(4-mcthoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-ethylphenyl)-1 II-pyrazo1-4-y1]-2-(4-rnethoxybenzy)-2H-tetrazole; 5-[5-bromo-1-(4-ethylphenyl)-I H-pyrazol-4-yl]-I -(4-tnethoxybenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-IH-pyrazol-4-yl]-2-(4-methoxybenzyl)-21J-tetrazole; 5-[5-bromo-1 -(4-methoxyphenyl)-iII-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2-methylphenyl)-1 H-pyrazol-4-y1]-2-(4-methoxybenzyl)-21-i-tetrazole: 5-L5-brorno-I -(2-methylphenyl)-1 H-pyrazo l-4-ylj -1 -(4-rnethoxyhenzyl)-21--i-tetrazoie; 5-{5 -bromo-I -(4-methylphenyl)-I H-pyrazol -4-yl] -2-(4-methoxyhenzyl)-21 1-tetrazole; 5-[5-bromo-1-(4-methylphenyl)-1H-pyrazol-4-yl]-1-(4-methoxybenzyl) -2H-tetrazole; 5-(-iodo-1-rnethy1-1H-pyrazo1-4-y1)-2-(4-rnethoxybenzyl)-2H-tetrazoIe; 5-(5-iodo-1-methyl-iII-pyrazol-4-yl)-I -(4-methoxybenzyl)-211-tetrazole; 5-(1-ethyl-5-iodo-1H-pyrazol-4-yl)-2-(4-methoxybenzyl)-2H-tetrazole; 5-(1-ethyl-5-iodo-1H-pyrazol-4-yl)--1-(4-rnethoxybenzyl)-2H-tetrazole; 5-[5-iodo--(2-niethylpropyl)-1 H-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[5-iodo-1 -(2-methylpropyl)-1 I-I-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-(1-benzyl-5-iodo-IFI-pyrazol-4-yl)-2-(4-methoxybenzyl)-211-tetrazole; 5-@ -henzyl-5-iodo-1H-pyrazol-4-yi)-1 -(4-methoxybcnzyl)-2H-tctrazolc; 5-(5-iodo-1 -phenyl-iT T-pyrazol-4-yl)-2-(4-methoxybenzyl)-211-tetrazole; 5-(5-iodo-I -phenyl-H-pyrazol-4-yI)-l -(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(2-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-rnethoxybcnzyi) -2H-tetrazole; 5-[1 -(2-chlorophenyl)-5-iodo-1IT-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-[1-(3-ehlorophenyl)-5-iodo-1i-I-pyrazol-4-yl]-2-(4-methoxybcnzyl) -2H-tetrazole; 5-[I -(3-ehlorophenyl)-5-iodo-1II-pyrazol-4-yll-1 -(4-methoxybenzyl)-21-T-tetrazole; 5-[i-(4-ehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazole; 5-{1 -(4-ehlorophenyl)-5-iodo-1H-pyrazol-4-ylj-1 -(4-rnethoxyhenzyl)-2H-tetrazolc; 5-Li -(2,3-diehlorophcny])-5-iodo-I H-pyrazol-4-yI]-2-(4-methoxybenzyl)-21-I-tetrazole; 5-[i -( ,3-dichlorophenyl)-5-iodo-1I-I-pyrazol-4-yi]-i -(4-rnethoxybenzyl)-2H-teftazole; 5-L1-(2,4-dieh1oropheny-5-iodo-1 H-pyrazoi-4-yl]-2-(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(2,4-dichiorophcnyl)-5-iodo-IH-pyrazol-4-yil-i-(4-methoxybenzyl) -2H-tetrazole; 5-[1-(2j-dichlorophenyl)-5-iodo-IIT-pyrazol-4-yll-2-(4-rnethoxybenzyl) -2F1-tetrazole; 5-[I -(2,5-dichlorophenyl)-5-iodo-IH-pyrazol-4-yl]-1-(4-methoxybcnzyi) -2H-tctrazole; 5-[1 -(2,6-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yll-2-(4-methoxybenzyi)-211-tetrazole; 541 -(2,6-diehlorophenyl)-5-iodo-I H-pyrazol-4-yIj-I -(4-methoxybenzyl)-2H-tenazo!e; 5-[I -(3,4-diehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazole; 5-[1-(3,4-dichlorophenyl)-5-iodo-1 H-pvrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tetrazole; 5-El -(3,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2-(4-rnethoxybcnzyl)-2H-tctrazok; 5-[I -(3,5-dich!orophenyl)-5-iodo-1H-pyrazol-4-yl]-i-(4-methoxybenzyl) -21-I-tetrazole; 5-[1-(2-bromophenyl)-5-iodo-1H-pyrazol-4-yI]-2-(4-methoxyhenzy!) -2H-tetrazo]e; 5-El -(2-brornophenyl)-5-iodo-1II-pyrazol-4-yl]-1 -(4-methoxybenzyl)-2H-tctrazole; 5-[1-(3-bromophcnyl)-5-iodo-1H-pyrazol-4-yI]-2-(4-rnethoxybenzyl) -2H-Letrazole; 5-Li -(3-hrornophenyl)-5-iodo-1 H-pyrazol-4-yIj-1-(4-rnethoxybenzyl)-21-1-tetrazoie; 5-11-(4-bromophenyl)-5-iodo-1 T-T-pyrazol-4-yl]-2-(4-methoxybenzyl)-2H-tetrazoie; 5-LI -(4-brornophenyl)-5-iodo-1H-pyrazol-4-yl]-1 -(4-methoxybenzyl)-211-tetrazole; 5-LI -4-fiuorophenyI)-S-iodo-1H-pyrazo1-4-y1]-2-(4-rnethoxybenzy1) -2H-tetrazo1e; 5-11-(4-fluorophenyl)-S-iodo-1 H-pyrazo!-4-yl]-1 -(4-niethoxybcnzyl)-2H-tetrazole; 5-[1-(2-fluorophenyl)-5-iodo-IH-pyrazol-4-yI]-2-(4-methoxyhenzyl) -2H-tcti-azolc; 5-[I -(2-fiuorophenyl)-S-iodo-1H-pyrazol-4-yl]-i -(4-methoxybenzyl)-2H-tetrazole; 5-[1 -(2,3-dimethylphenyl)-5-iodo-1 H-pyrazol-4-ylj-2-(4-methoxybenzyl)-2H-tetrazole; 5-Li -(2.3-dimelhyiphenyl)-5-iodo-1i-I-pyrazol-4-yl]-i-(4-methoxybenzy!) -2FT-tetrazo!e; 5-1-(2,4-dimethy1pheny1)-5-iodo-1II-pyrazo1-4-y1]-2-(4-methoxybenzy1) -2H-tctrazo1c; 5-[1-(2.4-dirncthylphcnyl)-5-iodo-1H-pyrazol-4-yfl-I -(4-methoxybenzyl)-2T1-tetrazole; 5-[i -(2.5-dirnethyiphenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazole; 5-[1 -(2,5-dimethylphenyl)-5-iodo-I H-pyrazoi-4-ylj-i-(4-methoxybenzyl)-211-tetrazole; 5-[1-(2,6-dimethyiphenyl)-5-iodo-IH-pyrazol-4-yl]-2-(4-methoxybenzyl) -2H-tetrazoie; 5-[1 -(2.6-dirnelhylphenyl)-5-iodo-iH-pyrazoi-4-yll-1-(4-methoxyhenzyl) -2H-tetrazole; 5-[1 -(3,4-dimcthylphcnyl)-5-ioclo-iH-pyrazoi-4-yl]-2-(4-methoxybenzyl) -2H-tetr'azole; 5-[1-(3,4-dimethyiphenyl)-5-iodo-iIi-pyrazot-4-yl]-i -(4-methoxybcnzyl)-21-I-tetrazole; 5-[1 -(3,5-dimethylphenyl)-5-iodo-1II-pyrazol-4-yIJ-2-(4-methoxybenzyl) -2H-tetrazole; 54] -(3.5-dimethylphenyl)-5-iodo-iH-pyrazol-4-yl]-1 -(4-niethoxybenzyl)-21-I-tetrazoie; 5-[1 -(2-ethylphenyl)-5-iodo-I [-I-pyrazol-4-ylj-2-(4-methoxybenzyl)-2l44elrazoie; 5-[1-(2-ethylphenyl)-5-iodo-1H-pyrazol-4-yl]-i -(4-methoxybenzyl)-21-I-tetrazole; 5-[i -(4-ethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-2-(4-rnethoxybenzyl)-21-I-tetrazole; 5-[1 -(4-ethylphenyl)-5-iodo-1H-pyrazol-4-yli-i -(4-rncthoxybenzyl)-2F{-tetrazole; S-L5-iodo-1 -(4-methoxyphenyl)-1II-pyrazol-4-yli-2-(4-methoxybenzyl)-2H-tctraz&c; S-LS-iodo-1-(4-methoxyphcnyl)-1H-pyrazol-4-yl]-1 -(4-rnethoxybenzyl)-2H-tetrazole; 5-L5-iodo-1-(2-methyiphenyi)-iII-pyrazol-4-yl]-2-(4-methoxybcnzyl) -2H-tctrazole; S-[5-iodo-1-(2-rnethylphenyl)-1 H-pyrazol-4-yI]-1 -(4-nietlioxybenzyl)-21-I-tetrazoie; 5-[5-iodo-1 -(4-me.thylphenyl)-I H-pyrazol-4-yl]-2-(4-methoxyhenzyl)-2H-tetrazole; 5-[5-iodo-1 -(4-methylphenyl)-IH-pyrazol-4-yl]-1-(4-methoxybcnzyl)-2H-tetrazole; 2-(3 -rnethylbenzyl)-5-( 1-methyl-i H-pyrazol-4-yl)-21-I-tetrazole; -(3-methylbenzyl)-5-(I -methyl-I H-pyrazol-4-yl)-2H-tetrazole; 5-( 1-ethyl-i H-pyrazol-4-yl)-2-(3-methylbenzyl)-2H-tetrazole; 5-(I -ethyl-1 H-pyrazol-4-yl)-1 -(3-rnethylhenzyl)-2H-tetrazole; 2-(3-methylbenzyl)-5-[I -(2-methyIpropy)-1 H-pyrazol-4-yl]-21-T-tetrazdle; I -(3-niethylbenzy!)-5-[1 -(2-mcthylpropyl)-H-pyrazol-4-yl]-2H-tetrazolc; 5-( 1 -benzyl-iT I-pyrazol-4-yl)-2-(3 -methylbenzyl)-21 1-tetrazole; 5-(1-benzyL-1H-pyra.zol-4-yl)-1-(3-methylbenzyl)-2H-tetra2ole; 2-(3-methylbenzyl)-5-( 1 -phenyl-1 I-i-pyrazol-4-yl)-2H-tetrazole; 1 -(3 -methylbenzyl)-5-( I -phenyl-iT I-pyrazol-4-yl)-21I-tetrazole; 5-[i -(2-chlorophenyi)-1 H-pyrazol-4-yl] -2-(3 -rnethylbenzyl)-2H-tetrazole; 5-[l -(2-ehlorophenyl)-l H-pyrazol-4-yl]-I -(3-rnethy1benzy-2H-tetrazo1e; 5-[1 -(3-chloropheny!)-1 i-T-pyrazo1-4-yI]-2-(3-methylhenzy-2H-tetrazo1e; 5-[1 -(3-chlorophenyl)-1H-pyrazol-4-yl]-1 -(3-methylbenzyi)-2H-tetrazoie; 5-[1 -(4-chlorophenyl)-iH-pyrazol-4-yl]-2-(3-methylbenzyl)-2[I-tetra2ole; 5-[ 1 -(4-ehiorophenyl)-1 H-pyrazol-4-yl]-i -(3-methylbcnzyl)-21-i-tetrazolc; 5-fl -(2,3-dichlorophenyl)-iIT-pyrazol-4-yfl-2-(3-methylbenzyl)-211-tetrazole; 5-[I -(2,3-diehlorophenyl)-I H-pyrazol-4-yl]-I -(3-methylhenzyl)-2H-tetrazole; 5-fl -(2,4-dichlorophenyl)-H-pyrazol-4-yl]-2-(3-niethylhenzyl)-2H-tetrazole; 5-[i-(2,4-diehlorophenyl)-1H-pyrazol-4-yij-1-(3-rnethylbenzyl) -2H-tetrazole; 5-[i -(2,5-dichlorophenyl)-1H-pyrazol-4-ylj-2-(3-methylbenzyl)-2H4etrazo]e; 5-[T -(2,5-dichloropheny!)-I i-i-pyrazol-4-yl]-1 -(3-methylbenzyl)-2i1-tetrazoIe; 5-11 -(2,6-dichlorophenyl)-1II-pyrazol-4-yfl-2-(3-methyibenzyl)-21-T-tetrazole; 5-[1 -(2.6-dichlorophenyl)-1H-pyrazol-4-yl]i -(3-methyibenzyl)-2H-tetrazole; 5-[1 -(3,4-diehlorophenyl)-1 H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(3.4-dichlorophcnyi)-1fI-pyrazol-4-yi]-1 -(3-methylhenzyi)-21-I-tetrazoie; 5-Il -(3.5-diclilorophenyi)-1H-pyrazol-4-yij-2-(3-methyibenzyl)-2H-tetrazole; 5-[I -(3,5-dichloropheny!)-IH-pvrazol-4-yl]-1 -(3-rnethy!henzyl)-2H-tctrazole; 5-[1 -(2-bromophenyi)-1 Ii-pyrazol-4-yll-2-(3 -methylbenzyl)-2i 1-tetrazole; 5-[1 -(2-bromophenyl)-I H-pvrazol-4-yI]-I -(3-methylhe.nzyl)-2H-tetrazole; 5-[1 -(3-bromophenyi)-1 H-pyrazoi-4-yll-2-(3-methylbenzyl)-21-I-tetrazole; 5-fl -(3-bromophenyl)-1 H-pyrazo!-4-yl]-I -(3-methy!benzy-2H-tetrazole; 5-{1 -(4-bromophenyl)-1 I-I-pyrazol-4-yI]-2-(3-methylhenzyl)-21-T-tetrazole; 5-[1 -(4-bromophenyl)-1H-pyrazol-4-yl]-1 -(3-rnethylbenzyl)-21-i-tetrazole; 5-11 -(4-fluorophenyl)-I H-pyrazoi-4-ylj-2-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(4-fluorophenyl)-1II-pyrazol-4-yli-1 -(3-methylbenzyl)-21-1-tetrazole; 541 -(2-fluorophenyl)-IH-pyrazol-4-yl]-2-(3-metlwlbenzyl)-211-teirazole; 5-[1 -(2-fluorophenyl)-1 H-pyrazol-4-yl]-1 -(3-methyhenzy-2H-tetrazo1e; 5-[ 1 -(2,3-dimethy1phenv1)-1I-I-pyrazo1-4-yfl-2-(3-meihy1benzv-2l-l-teirazok; 5-Fl -(2,3-dimethylphenyl)-1U-pyrazol-4-yl]-1-(3-methvlbenzyl)-2H-tctrazole; 5-fl -(2,4-diniethyipheny])-1H-pyrazol-4-yl]-2-(3-methylbenzvl)-211-tetrazole; 5-[1-(2,4-dirnethylphenyl)-1H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-11 -(2,5-dimethylphenyl)-lIl-pyrazol-4-yI]-2-(3-methvlbenzy])-2T-I-tetrazo]c; 5-[1 -(2,5-dirnethylphenyl)-l H-pyrazoL-4-ylj-1-(3-methylbenzyl)-2H-tetrazole; 5-[i-(2,6-dirnethy]phenyl)-1H-pyrazol-4-yl]-2-(3-rnethvlbenzyl) -2H-tetrazole; 5-11-(2,6-dirnethylphenyl)-1[I-pyrazol-4-yl]-1-(3-methylbenzyl) -21-I-tetrazole; 5-[1 -(3,4-dimethylphenyl)-1 H-pyrazol-4-yl]-2-(3-methylbenzyl)-211-tetrazole; 5.-[1 -(3,4-dimethylphenyl)-1H-pyrazol-4-yl]-1-(3-methylbenzyl)-2H-tetrazole; 5-[1 -(3,5-dirnethylphenyl)-1 H-pyrazol-4-ylj-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[ 1 -(3,5-dirncthylphcnyl)-1 H-pyrazol-4-yl]-1 -(3 -methythenzyl)-2H-tefrazole; 5-[1 -(2-ethyiphenyl)-I H-pyrazol-4-yI]-2-(3 -rnethylbenzyl)-2H-tetrazo[e; 5-[1 -(2-ethylphenyl)-1FI-pyrazol-4-yl]-1-(3-methylbenzyl)-2H-teirazole; 5-[1 4-ethvlpheiiyl)-IH-pyrazol-4-yl]-2-(3 -methylbenzyl)-2H-tetrazole; 5-[ I -(4-ethylphenyl)-1 H-pyrazol-4-yl]-I -@ -rnethylbcnzyl)-2H-tetrazole; 5-[ 1 -(4-methoxyphenyl)-1 l-T-pyrazol-4-yl]-2-(3-methylbenzyl)-2F1-tetrazole; 5-El -(4-methoxyphenyl)-1 H-pyrazo-4-yl]-1-(3-methyibenzy1)-2H-tetrazo1e; 2-(3-rnethylbenzyl)-5-[1 -(2-methyiphenyl)-IH-pyrazol-4-yl]-2H-tetraz&e; 1 -(3-methylbenzyl)-5-11 -(2-methvlphenyl)-1fI-pyrazol-4-yfl-211-tetrazole; 2-(3-methylbenzyl)-5-[1 -(4-methyiphenyl)-1H-pyrazol-4-yl]-2H-tetrazole; 1-(3-rnethylbenzyl)-5-[1 -(4-methyiphenyl)-IH-pyrazol-4-ylj-2H-tetrazole; 5-(5-chloro-1-methyl-i I I-pyrazol-4-yl)-2-(3 -methylhenzyl)-211-tetrazoie; 5-(5-chloro-i-methyl-iH-pyrazol-4-yl)-1-(3-meQylbenzyl)-2H-tetrazole; 5-(5-chloro-1-ethyl-i H-pyrazol-4-yl)-2-(3-niethylhenzyl)-2H-tetrazole; 5-(5-chloro-1-ethyl-iII-pyrazol-4-yl)-1 -(3-methyffienzyl)-2I1-tetrazole; 5-[5-ch]oro-I -(2-methylpropyl)-1 H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazo]e; 5-[5-chloro-1 -(2-methyipropyl)-1l-I-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-(1 -benzy-5-ch1oro-l H-pyrazol-4-yl)-2-(3-methylbenzyl)-2H-tetrazole; 5-(1 -benzyl-S-ehloro-IH-pyrazol-4-yl)-I -(3-rnethylbenzyl)-2H-tetrazole; 5-(5 -chioro-1 -phenyl-1 H-pyrazol-4-yl)-2-(3-mcthylbcnzyl)-211-tctrazolc; 5-(5-chloro-1 -phenyl-1 H-pyrazol-4-vl)-1-(3-rneflylbenzyl)-211-tetrazole; 5-[5-chioro-1 -(2-ch1oropheny1)-iH-pvrazo1-4-y1]-2-T-rnethyIhenzy1)-2H-tetrazo!e; 5-[5 -ehloro-I -(2-chlorophenyl)-1 H-pyrazol-4-yll -1 -(3 -methylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(3-chlorophcnyl)-1H-pvrazol-4-yl]-2-(3-iiiethylbenzyl)-2H-tetraz6le; 5-[5-chioro-1 -(3-chlorophenyl)-IH-pyrazol-4-yI]-I -(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-chlorophenyl)-iH-pyrazol-4-yl]-2-(3-rnethylhenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-chloroplienyl)-i H-pyrazol-4-yll-i-(3-methylhenzyl)-211-tetrazole; 5-[5-ehloro-1 -(2,3-dichlorophenyl)-1H-pyrazol-4-ylj-2-(3-rnethyibenzyi)-2H4etrazole; 5-[5-chioro-1 -(2.3-dichlorophenvl)-I 1-i-p yrazol-4-yl]-1 -(3-methylbenzyi)-2H-tetrazole; 5-[5-chloro-1 -(2.4-dich1oropheny1)-1iI-pyrazo1-4-y1]-2-(3-rnethyIbenzy-2H-tetrazo1e; 5-[5-ehIoro-I -(2.4-dichlorophenyl)-1H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2,5-dichiorophenyl)-I H-pyrazol-4-ylj-2-(3-rnethylbenzyl)-2H-teirazole; 5-[5-chloro-1 -(2,5-diehlorophenyl)-1II-pyrazol-4-yl]-I -(3-methyIbenzy-2H-tetrazoIe; 5-[5-chloro-1 -(2.6-diclilorophenyl)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl)-211-tctrazolc; 5-[5-chloro-i-(2,6-dichlorophenvl)-1i-1-pyrazol-4-ylj-1 -(3-methylhenzyl)-214-tetrazole; 5-[5-chloro-1-(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(3-methylbenzyl) -2H-tetrazolc; 5-[5-chloro-1 -(3,4-dichloropheny[)-I H-pyraz&-4-yl]-I -(3-methylbenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(3,5-diehlorophenyl)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-I -(3,5-dichlorophenyl)-IH-pyrazol-4-yl]-i-(3-methyibenzyl)-211-tetrazole; 5-[I -(2-brornophenyl)-5-chloro-IH-pyrazol-4-y[]-2-(3-methylbenzvl) -21-T-tetrazole; 5-1i-(2-bromopheny-5-ch1oro-1ll-pyrazoI-4-yII-I -(3-niethylbcnzyl)-2T-i-tetra7olc; 5-Li -(3-bromophenyl)-5-chloro-1I-I-pyrazol-4-yfl-2-(3-methylhenzvl) -21-i-tetrazole; 5-Li -(3-bromophenyl)-5-chloro-1H-pyrazoi-4-yl]-i-(3-niethyibenzyl) -2H-telra2ole; 5-LI -(4-bromophenyl)-5-chloro-I H-pyrazol-4-yl]-2-(3-rncthyibcnzyi)-2H-tetrazole; 5-[i -(4-bromophenyl)-5-chloro-1I-I-pyrazoi-4-yl]-I -(3-methylhenzyl)-214-tetrazole; 5-[5-chloro-I -(4-fluorophenyl)-I H-pyrazol-4-yij-2-(3-methylbenzvl)-2H-tetrazole; 5-[5-chloro-1 -(4-fluorophenyl)-IFI-pyrazol-4-yfl-1 -(3-methylbenzyl)-2i-1-tetrazole; 5-[5-chloro-I -(2-fiuorophenyl)-IH-pyrazol-4-yi]-2-(3-melhylbenzyl)-2H-tetrazole; 5-[5-chloro-i-(2-fluorophenyl)-IH-pyrazol-4-vll-1-(3-methylbenzyl) -2H-tetrazole; 5-[5-chioro-1 -(2,3-dirnethviphenyl)-iII-pyrazol-4-yIl-2-(3 -methyibenzyl)-2H-tetrazolc; 5-[5-chioro-i-(2,3-dimcthylphenyl)-1H-pyrazol-4-yl]-1-(3-rnethylbenzyl) -2H-tetrazole; 5-[5-chloro.-1 -(2,4-dirncthylphenyl)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-1-(2,4-dirnethylphenyl)-1I-I-pyrazol-4-yl]-1-(3-rnethylbenzyl) -2H-tetrazole; 5-[5-chloro-1 -(2,5-dimethylphcnyl)-1H-pyrazol-4-yl]-2-(3-rnethylbcnzyl)-2H-tetrazole; 5-15-chloro-1-(2,5-dimethylphenyl)-1II-pyrazol-4-yli-1-(3-methylbenzyl) -21I-telrazole; 5-[5-chloro-l -(2,6-dimethylphenyl)-1 H-pyraz&-4-yl]-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-1-(2,6-climethylphenyl)-1H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-l-(3,4-dirnethylphenyl)-1 l-I-pyrazol-4-ylj-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-1-(3,4-dimethylphenyl)-1H-pyrazol-4-ylj-l-(3-rnethylbenzyl) -2H-tetrazoie; 5-[5-chloro-1 -(3,5-dimethyiphenyl)-l1-i-pyrazol-4-yl]-2-(3-n-iethylbenzyl) -2H-tctrazolc; 5-[5-chloro-l -(3.5-dimethvlphenyl)-1TI-pyrazol-4-yfl-1-(3-methylbenzyl)-211-tetrazole; 5-[5 -chioro-1 -(2-ethylphenyl)-1H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-1-(2-ethylphenyl)-1H-pvrazol-4-yl]--1 -(3-rnethylbenzyl)-2H-tetrazole; 5-[5-chloro-i-(4-cthylphenyl)-l H-pyrazo1-4-y]-2-(3-methylhenzyI)-2H-tetrazoIe; 5-15-chloro-1 -(4-ethyiphenyl)-11-1-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-methoxyphenyl)-1H-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-methoxyphenyl)-1 1-hpyraz&-4-yI]-1 -(3-methylhenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(2-rnethylphcnyl)-1H-pyrazol-4-yl]-2-(3-mcthylbenzyl)-2H-tetrazole; 5-[5-chloro-i-(2-methylphenyl)-1 TI-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-chloro-I -(4-rnethylphenyl)-IH-pyrazol-4-yl]-2-(3-rncthylbenzyl)-2H-tctrazole; 5-[5-chloro-1 -(4-methylphenyl)-1II-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-(5-bromo-I-methyl-I H-pyrazol-4-yI)-2-(3-methylbenzyl)-2H-tetrazole; 5-(5-hromo-1-methyl-I H-pyrazol-4-yl)-1 -(3-methylbenzyl)-21 1-tetrazole; 5-(5-brorno-1 -ethyl-1Ji-pyrazol-4-yl)-2-(3-rnethylbenzyl)-2H-letrazole; 5-(5-brorno-1-ethyl-IH-pyrazol-4-yl)-I -(3-methylbcnzyl)-2H-tetrazole; 5-[5-bronio-I -(2-methyipropyl)-I H-pyrazol-4-yI]-2-(3-methylhenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-methylpropyl)-1I-I-pyrazol-4-yl]-1-(3-rnethylbenzyl)-2H-tetrazole; 5-(I -benzyl-5-bromo-1H-pyrazol-4-yl)-2-(3-methylbenzyl)-2H-tetrazole; -0 -henzyl-5-hromo-I H-pyrazol-4-yl)-1 -(3-methylhenzyl)-2H-tetrazole; 5-(5-brorno-1 -phenyl-III-pyrazol-4-yl)-2-(3-methylberzyl)-211-tetra2ole; 5-(5-brorno-I -phenyl-I H-pyrazol-4-yI)-1 -(3-methy!benzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-chlorophenyl)-I H-pyrazol-4-yl] -2-(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-i-(2-chlorophenyl)-I H-pyrazo]-4-yij-I -(3-methylbenzyi)-2H-teu-azole; 5-[5-bromo-1 -(3-chlorophenyl)-IH-pyrazol-4-ylJ-2-(3-rncthylhcnzyl)-2H-tctrazole; 5-[5-bromo-1 -(3-chlorophenyl)-I H-pyrazol-4-yl]-1 -(3-methylbenzyl)-211-tetra.zole; 5-[5-bromo-1 -(4-chiorophenyl)-1 II-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-tetrazok; 5-[5-brorno-1 -(4-chloropheny)-I I-I-pyrazol-4-ylj-1 -(3-rnethylbenzyl)-211-tetrazole; 5-[5-bromo-1-(2,3-diclilorophenyl)-1H-pyrazol-4-y!]-2-(3-rnethylbenzyl) -2H-tctrazole; 5-[5-brorno-1 -(2,3-dichlorophenyl)-1II-pyrazol-4-yli-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-brorno-1-(2.4-dicblorophenyl)-1H-pyrazol-4-yI]-2-(3-methylhenzyl) -2H-tetrazole; 5-[5-bromo-1-(2,4-dichlorophenyl)-1T-T-pyrazo]-4-yfl-1 -(3-rnethylbenzyl)-2H-tetrazole; 5-[5-bromo-1-(2,5-dichlorophenyl)-1H-pyrazol-4-ylj-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[5-brorno-1-(2,5-dichlorophenyl)-1H-pyrazol-4-ylj-1 -(3-methylbenzyl)-211-tetrazole; 5-[5-bromo-1 -(2,6-dichlorophcnyl)-1H-pyrazol-4-ylj-2-(3-niethylbenzyl)-2H-tetrazole; 5-[5-bromo-1-(2,6-dicblorophenyl)-1iI-pyrazol-4-yI]-1 -(3-methylbenzyl)-2H-tetrazo[e; 5-[5-brorno-1-(3,4-dichlorophenyl)-1FI-pyrazol-4-yll-2-(3-methylbenzyl) -211-tetrazole; 5-[5-brorno-I -(3,4-dieh1oropheny1)1H-pyrazo1-4-y1j-1 -(3-rnelhythenzyl)-2H-ietrazole; 5-[5-bromo-1-(3,5-dichlorophenyl)-1 H-pyrazoi-4-ylj-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-brorno-1 -(3,5-dichlorophenyl)-1 H-pyrazol-4-yll -1 -(3-mcthylbcnzyl)-21 1-tetrazoic; 5-[5-bromo-1 -(2-brornophenyl)-1 II-pyrazol-4-yll-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2-hrornophenyl)-1 H-pyrazol-4-yl]-1 -(3-methylbenzyl)-2H-tetrazole; 5-[5-bromo-1-(3-bromophcnyl)-1H-pyrazol-4-yIj-2-(3-metbylbenzyl) -2H-tetrazole; 5-[5-bromo-I -( -brornophenyl)-I H-pyrazol-4-yl]-I -(3-methylhenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-bromophenyl)-1 H-pyrazo1-4-y1]-2-(3-rnethyIbenzy-2H-tetrazo1e; 5-[5-brorno-I -(4-bromophenyl)-1 H-pyrazol-4-yfl-1-(3-methvlbenzyl)-211-tetrazole; 5-[5-bromo--(4-fluorophenyl)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2F1-tetrazole; 5-[5-bromo-1 -(4-fluorophenyl)-1iI-pyrazol-4-yfl-1 -(3-methylhenzyl)-21-1-tetrazole; 5-[5 -brorno-I -(2-Iluorophenyl)-I 1-I-pyrazol-4-yl]-2-(3 -rnethylbenzyl)-211-tetrazole; 5-[5-hrorno-I -(2-fluorophenyl)-1 H-pyrazol-4-ylj-1-(3-methylhenzyl)-2H-tetrazole; 5-{5-bromo-1 -(2,3-dimethylphenyl)-1 H-pyrazol-4-yI]-2-(3-niethylbenzyl)-2H-tctrazole; 5-[5-brorno-1 -(2,3-dirnethylphenyl)-I H-pyrazol-4-yl]-I -(3-rnethylbenzyl)-21-I-tetrazole; 5-[S-bromo-1 -(2,4-dimethyiphenyl)-1H-pyrazol-4-ylj-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-bromo-1-(2,4-dimcthylphcnyl)-1 II-pyrazol-4-yl]-1-(3-methy!benzyl)-2H-tetrazole; 545-bromo-1 -(2,5-dirnethylphenyl)-1H-pyruzol-4-yfl-2-(3-methylbenzyl)-21-I-tetrazole; 5-[5-hromo-1 -(2.5-dirnethylphenyl)-1H-pyrazol-4-ylj-I -(3-rnethylbenzyl)-2H-tetravole; 5-[5-bromo-1 -(2,6-dimethylphenyl)-I I1-pyrazol-4-ylI-2-(3-methylbenzyl)-2H-te.trazolc; 5-[5-bromo-1 -(2.6-dimethy!phenyl)-1 H-pyrazol-4-yI]-I -(3-rnethylbenzyl)-2H-tetrazole; 5-{5-brorno-1 -(3.4-dimethy1pheny1)-1H-pyrazol-4-v1-2-(3-rncthy1benzy1)-2H-tetrazoIe; 5-[5-bronio-l -(3,4-dimethylphenyl)-I I-I-pyrazo]-4-ylj-i-(3-methylbenzyl)-211-tetrazole; 5-[5-bromo-1 -(3,5-dimethylphenyl)-1H-pyrazol-4-yfl-2-(3-rnethylbenzyl)-2H-tetrazole; 5-[5-bromo-1-(3,5-dirnetIw1pheny1)-1II-pyrazo1-4-y1]-1-(3-rnethy1benzy) -2H-tetrazoIe; 5-L5-brorno--(2-ethyiphenyl)-I E{-pyrazol-4-y1]-2-(3-rncthy1benzy)-2H-tetrazo1e; 5-[5-brorno-1-(2-cthylphenyl)-1H-pyrazol-4-yll-1-(3-methylbenzyl) -211-tetrazole; 5-[5-brorno-1 -(4-ethy]p]ieny)-1 H-pyrazol-4-yl]-2-(3-rnethylbcnzyl)-2H-tctrazole; 5-[5-brorno-1 -(4-cthylphenyl)-1H-pyrazol-4-yl]-1-(3-methylbenzyl)-211-tetrazole; 5-[5-bromo-1-(4-rnethoxyphenyl)-l H-pyrazol-4-yI]-2-(3-rnethylhenzyl)-2H-tetrazok; 5-[5-hromo-1 -(4-methoxypheny1)-1II-pyrazo1-4-y1]-1-(3-inethy1benzy1)-2H-ieLrazoe; 5-[5-bromo-1-(2-methylphenyl)-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[5-bromo-1-(2-methylphenyl)-1 H-pyrazol-4-yI]-T -(3-methylhenzyl)-21I-tetrazole; 5-[5-bromo-1 -(4-methylphenyl)-1TI-pyrazol-4-yl]-2-(3-methylbenzyl)-2H-telrazole; 5-[5-bromo-1 -(4-rnethylphenyl)-1H-pyrazol-4-yl]-1-(3-rnethylbenzyl)-2H-tetrazole; 5-(5-iodo-1-methyl-1H-pyrazol-4-yl)-2-(3-methylhenzyl)-2H-tetrazole; 5-(5-iodo-1-methyl-H-pyrazol-4-yl)-1 -(3 -methylbenzyl)-2H-tetrazole; 5-(1 -ethyt-5-iodo-1IT-pyrazol-4-yl)-2-(3-methylbenzyl)-2H-tetrazole; 5-(1-cthyl-5-iodo-1II-pyrazol-4-yl)-1-(3-methylbenzyl)-2H-tetrazole; 5-15-iodo-i-(2-rnethylpropyl)-I H-pyrazol-4-yl]-2-(3-rncthylbcnzyl)-21-I-tetrazole; 5-[5-iodo-1-(2-methylpropyl)-1II-pyrazoh4-yI]-1 -(3-methylhenzyl)-2H-tetrazole; 5-(1 -benzyl-5-iodo-I H-pyrazol-4-yl)-2-(3-rncthylbenzyl)-2H-tetrazole; 5-(1-hcnzyk5-iodo-1H-pyrazol-4-yl)-1-(3-methylbenzyl)-2H-tetravok; 5-(5-iodo-1-phenyl-1II-pyrazol-4-yl)-2-(3-rnethylbenzyl)-2H-tetrazole; 5-(5-iodo-1-phenyl-1H-pyrazol-4-yl)-i-(3-methylhenzyl)-21-T-tetraz&e; 5-[1 -(2-chlorophenyl)-5-iodo-H-pyraz&-4-yli-2-(3-methylbenzyl)-21-I-tetrazole; S-[1 -(2-chlorophenyl)-5-iodo-1Ii-pyrazol-4-yl]-1-(3-methylbenzyl) -2H-tetrazole; 5-{1-(3-chlorophenyl)-5-iodo-IH-pyrazol-4-ylj-2-(3-mcthylbenzyl) -21-I-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-1 I-I-pyrazol-4-yll-1 -(3-rnethylbenzyl)-2H-tetrazok; 5-fl -(4-ehlorophenyl)-5-iodo-1II-pyrazol-4-yli-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[1-(4-chlorophcnyl)-5-iodo-1I-I-pyravol-4-yl]-1 -(3-metiiy]henzyl)-2H-tctrazole; 5-[1-(2,3-dicfflorophenyl)-5-iodo-1 H-pyrazo1-4-y1-2-(3-methy1benzy1)-2H-tetrazo1e; 5-[l -(2,3-clichlorophenyl)-5-iodo-1II-pyrazol-4-yl]-1-(3-methylbenzyl) -2H-tetrazole; 5-[1 -(2,4-dichloroplienyl)-5-iodo-H-pyrazol-4-yl]-2-(3-methythenzyl) -2H-tetrazole; 5-[1 -(2,4-dichlorophenyl)-5-iodo-IH-pyrazol-4-yll-1-(3-methylbenzyl) -2H-tetrazole; 5-[1-(2.5-dichlorophenyl)-5-iodo-IH-pyrazol-4-yl]-2-(3-rneihylhenzy[) -2H-tetrazole; 5-[1 -(2,5-dichlorophcnyl)-5-iodo-1H-pyrazol-4-yl]-1-(3-methylbenzyl) -211-tetrazole; 5-[1 -(2,6-dichlorophenyl)-5-iodo-1I-I-pyrazol-4-yl]-2-(3-methylbcnzyl) -2H-tetrazole; 5-[1 -(2,6-clichlorophenyl)-5-iodo-1H-pyrazol-4-yll-i-(3-methylbenzyl) -211-tetrazole; 5-[1 -(3,4-dichlorophcnyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-rnetbylhenzyl) -2H-tetrazolc; 5-[1 -(3.4-dichlorophenyl)-5-iodo-1II-pyrazol-4-yli-i -(3-methylbenzyl)-2F1-tetrazole; 5-[1 -(3,5-dichlorophcnyl)-5-iodo-IH-pyrazol-4-yl]-2-(3-methylbenzyl) -2H-tetrazole; 541 -(3,5-dichlorophenyl)-5-iodo-1H-pyrazol-4-yl]-1-(3-methylbenzyl) -2H4etrazole; 5-[1 -(2-brornophenyl)-5-iodo-I H-pyrazo1-4-y]-2-(3-nieLhyIbenzy1)-2H-tetrazoIe; 541 -(2-brornopheny)-5-iodo-1 H-pyrazol-4-yl]-1-(3-methylbenzyl)-21-I-tetraz6le; 5-[I -(3-brornophenyl)-5-iodo-IH-pyrazol-4-ylj-2-(3-rnethvlbenzyl) -2H-tetrazole; 5-[1 -(3-brornophenyl)-5-iodo-1II-pyrazol-4-yli-1 -(3-methylbenzyl)-21-1-tetrazole; 5-[1 -(4-bromophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-methylbenzyl)-211-tetrazole; 5-[I -(4-hromophenyl)-5-iodo-I H-pyrazol-4-yl]-1-(3-rnethylbenzyl)-2H-tetrazole; 5-[1 -(4-fluorophenyl)-5-iodo-U-I-pyrazol-4-yI]-2-(3-methylbenzyl) -2H-tetrazole; 5-[1 -(4-lluorophenyl)-5-iodo-1H-pyrazol-4-yl]-1 -(3-rnethylbenzyl)-211-tetrazole; 5-[i -(2-fluorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[1 -(2-f1uoropheny!)-5-iodo-l-I-pyrazol-4-yI]-1 -(3-methy1benzy)-2H-tetrazo1e; 5-[ 1 -(2,3 -dimethylphenyl}-5-iodo-1R-pyrazol-4-yi]-2-(3-methylbcnzyi)-2H-tctrazoie; 5-[1 -(2,3-dirnethylphcnyl)-5-iodo-1H-pyrazol-4-ylj-1 -(3-rncthylhenzyl)-2H-tetrazolc; 5-[i -(2,4-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-(3-methylbenzyi) -2H-tetrazoie; 5-{1 -(2,4-dirnethylphenyl)-5-iodo-iH-pyrazol-4-ylj-1-(3-rnethylbenzyl) -2H-tetrazole; 5-{1 -(2,5-dimetbylphenyl)-5-iodo-IH-pyrazol-4-yI]-2-(3-rnethylhenzyl) -2H-tetrazole; 5-Ii-(2,5-dimethylphenyl)-5-iodo-iil-pyrazol-4-yll-1-(3-methylbenzyl) -2H-tetrazole; 5-Li -(2,6-dimethylphenyl)-5-iodo-1H-pyrazol-4-ylj-2-(3-methylbenzyl) -21-I-tetrazole; 5-H -(2,6-dimcthylphenyl)-5-iodo-I H-pyrazo].-4-ylj-I -(3-niethylbenzyl)-2H-tetrazole; 5-LI -(3,4-dimethylphenyl)-5-iodo-I iJ-pyrazol-4-yI]-2-(3-methylhenzyl)-2H-tetrazole; 5-[1-(3,4-dirnethyiphenyi)-5-iodo-1H-pyrazol-4-yl]-i-(3-methylbenzyl) -2H-tetrazole; 5-[1-(3.S4imethyiphenyi)-S4odo-1H-pyrazol-4-yl]-2-(3-methyibenzyl) -2H-letrazole; 5-[1 -(3.5-dimethylphenyl)-5-iodo-1 T-T-pyrazol-4-yI]-1 -(3-mcthylhenzyl)-2H-tctrazolc; 5-[i -(2-ethylphenyl)-5-iodo-iII-pyrazol-4-yl]-2-(3-rnethylbenzyl) -2H-tetrazole; 5-[i -(2-ethylphcnyl)-5-iodo-1H-pyrazol-4-ylj-1 -(3-rnethylbenzyl)-2H-tetrazo!e; 5-[i -(4-ethylphenyl)-5-iodo-iH-pyrazo1-4-y1-2-(3-methy1benzy1)-2H-tetrazoic; 5-[1 -(4-ethylphenyl)-5-iodo-1 H-pyrazol-4-yl]-I -(3-rnethylbenzyl)-21-i-tetrazoie; 5-L5-iodo-1 -(4-methoxyphenyl)-iH-pyrazoi-4-ylJ-2-(3-mcthylbcnzyl)-2H-tetrazole; 5-L5-iodo-I -(4-methoxyphenyl)-1 H-pyrazol-4-yIj-I -(3-rnethylbenzyl)-21I-tetrazole; 5-[5-iodo-1 -(2-methylphenyl)-1 I-1-pyrazo!-4-yI]-2-(3-rnethylbenzyl)-211-tetrazole; 5-[5-iodo-I -(2-methylphenyl)-1H-pyrazol-4-yl]-1-(3-rnethylhenzy!)-2H-tetrazole; 5-[5-iodo-1 -(4-methylphenyl)-1 H-pyrazol-4-ylj-2-(3-methylbenzyl)-2H-tetrazole; 5-[5-iodo-I -(4-methylphenyl)-IH-pyrazol-4-ylJ-1-(3-rnethylbenzyl)-2H-tefrazole; 5-0 -methyl-I H-pyrazol-4-yl)-2-(4-riitrobenzyl)-211-tetrazole; 5-(1-methyl-III-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-tetrazole; 5-(1-ethyl-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-211-tetrazole; -0 -ethyl-I H-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-tetrazole; 3-[1 -(2-methylpropyl)-IH-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[1 -(2-rnethylpropyl)-1H-pyrazol-4-yfl-1 -(4-nitrobenzyl)-2H-tetrazole; 5-(1-benzyl-IH-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(1 -benzyl-I H-pyrazol-4-yl)-1 -(4-nitrobenzyl)-2H-tetrazole; 2-(4-nitrobenzyl)-5-( I -phenyl-I H-pyrazol-4-yl)-2H-telrazole; 1-{4-nitrobenzyl)-5-(1-phenyl-1II-pyrazol-4-yl)-2H-tetrazoie; 5-[I -(2-ehlorophenyl)-I H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazo[e; 5-[1 -(2-chlorophenyl)-1 H-pyrazol-4-yfl-1-(4-nitrobenzyl)-211-tetrazole; 5-[1 -(3-chlorophenyl)-IH-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1-(3-chloropI1el1yl)-1 H-pyrazol-4-yl]-1-(4-nitrobenzyl)-211-tetrazole; 5-[1 -(4-chlorophenyl)-IJiI-pyrazol-4-yl]-2-(4-nii.robenzyl)-21-I-tetrazole; 5-[1 -(4-cblorophenyl)-1I-1-pyrazol-4-yli-1-(4-nitrobenzyl)-2H-tctrazole; 5-[ 1 -(2,3-dichlorophenyl)-1 H-pyrazol-4-yi]-2-(4-nitrobenzyl)-21 1-tetrazole; 5-[1-(2,3-diclilorophenyl)-1H-pyrazol-4-ylJ-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[1-(2,4-dichlorophenyl)-1H-pyrazol-4-ylj-2-(4-nitrohenzyl)-2H-tetrazole; 5-[1 -(2,4-dichorophenyI)-1H-pyrazol-4-ylJ-1-(4-nitrobenzyl)-211-tetrazole; 5-[1 -(2,5-dichlorophenyl)-1 H-pyrazol-4-ylj-2-(4-nilrobenzyl)-2H-tetrazole; 5-[1 -(2,5-dichlorophenyl)-1I-I-pyrazol-4-yl]-1-(4-nitrohenzyl)-2H-tetrazole; 5-41 -(2,6-dichlorophenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobenzyl)-21T-tetrazole; 5-[1 -(2,6-dichlorophenyl)-1 H-pyrazol-4-yl]-1 -(4-nitrohenzy])-21-1-tetrazole; 5-[1 -(3,4-dichlorophenyl)-1II-pyrazol-4-yl]-2-(4-nitrobcnzyl)-2H-tctrazole; 5-[1 -(3,4-dichlorophenyl)-1 H-pyrazoE-4-yi]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(3,5-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrohenzyl)-2H-tetraz&e; 5-[I -(3,5-dichiorophenyl)-H-pyraz&-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(2-bromophenyl)-1H-pyrazol-4-yl]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[1 -(2-hrornophenyl)-I H-pyrazol-4-ylj-1-(4-nitrobenzyl)-211-tetrazole; 5-[1-(3-bromophenyl)-1II-pyrazol-4-yl]-2-(4-nitrohenzyl)-2N-tetrazoie; 5-[1 -(3-bromophenyl)-1 H-pyrazol-4-yl] -1 -(4-nitrobcnzyl)-211-tctrazole; 5-[I -(4-bromophenyl)-I H-pyraz&-4-ylj-2-(4-nitrobenzyl)-2F1-tetrazole; 5-[l -(4-bromophenyl)-1 H-pyrazol-4-yl] -1 -(4-nitrobcnzyl)-2H-tetrazole; 5-fl -(4-fluoroplienyl)-] H-pyrazol-4-yl]-2-(4-nitrobenzyl)-21T-tetrazole; 5-[1-(4-fluorophcnyl)-1H-pyrazol-4-yl]-1 -(4-nitrohenzyl)-2H-ietrazole; 5-F) -(2-Iluorophenyl)-] H-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[ 1 -(2-fluoroplienyl)-1FI-pyrazol-4-yfl-1 -(4-nitrobenzyl)-2H-tetrazole; 5-El -(2,3-dimethylphenyl)-1 H-pyrazol-4-yl j-2-(4-nitrobenzyl)-21 1-tetrazole; 5-[l -(2,3-dimcthylphenyl)-iH-pyTazol-4-yl]-1-(4-nitrobenzyl)-2H-telrazole; 5-[1 -(2,4-dimethylphenyl)-I H-pyrazol-4-yl]-2-(4-nitrobcnzyl)-2H-tetrazole; 5-[i-(2,4-dirnethyiphenyl)-IH-pvrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-[1 -(2,5-dimethy1phenyl)-1H-pyrao1-4-v1]-2-(4-niIrobenzyl)-2H-tetrazo1e; 5-[1-(2,5-dirnethylphenyl)-IH-pyrazol-4-yl]-I -(4-nitrobenzyi)-2H-tctrazole; 5-[1 -(2,6-dirnethylphenyl)-IF1-pvrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[l -(2,6-dirnethylphenvl)-IH-pvrazol-4-vl]-1 -(4-nilrobenzyl)-2H-tetrazole; 5-[I -(3,4-dimethy!phenyl)-I H-pyrazol-4-y]]-2-(4-nitrobenzyl)-21-i-tetrazole; 5-[I -(3,4-dimethylphenyl)-1H-pyrazol-4-vfl-1 -(4-nitrobcnzyl)-2H-tctrazolc; 5-[l -(3,5-dimethylphenyl)-I H-pyrazoi-4-yIj-2-(4-nitrobenzyl)-21-1-tetrazole; 5-[1-(3,5-dimethylphenyl)-1IT-pyrazol-4-yl]-1-(4-nitrobcnzyl) -2H-tctrazole; 5-[1 -(2-ethylphenyl)-I H-pyrazol-4-yl]-2-(4-nitrohenzyl)-211-tetrazole; 5-[1-(2-cthylphcnyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[1-(4-ethylphenyl)-IH-pyrazol-4-yI]-2-(4-nitrobenzyl)-2H-tetrazole; 541 -(4-ethyiphenyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2U-tetrazole; 5-[ 1 -(4-methoxyphenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1-(4-methoxyphenyl)-I H-pyrazol-4-yl]-I -(4-nitrobenzyl)-21-I-tetrazole; 5-[1-(2-methylphenyl)-1II-pyrazol-4-yll-2-(4-nitrobenzyl)-2H-tetrazole; 541 -(2-methylphenvl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[ 1 -(4-methylphenyl)-I 1-I-pyrazol-4-yl]-2-(4-nitrohenzyl)-2 H-tetrazole; 5-[1-(4-methylphenyl)-IH-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-(5-chloro-1 -methyl-I H-pyrazol-4-vI)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-ehloro-1-methyl-1II-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-tctrazole; 5-(5-chloro-1 -ethyl-I H-pyrazol-4-yl)-2-(4-nitrohenzyfl-2H-tetrazole; 5-(5-ehloro-1-ethyl-i II-pyrazol-4-yl)-1 -(4-nitrobenzyl)-2H-tetrazolc; 3-[5-chloro-1-(2-rnethylpropyl)-1H-pyrazol-4-yI]-2-(4-nitrobenzyl) -211-tetrazole; 5-[5-chloro-1 -(2-rnethylpropyl)-1II-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-(1-benzyl-5-chloro-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-21-I-tetrazole; 5-(1-benzvl-5-chloro-1H-pyrazol-4-y1)-1-(4-nitrobenzyl)-2H-tetraz&e; 5-(5 -chioro-1 -phenyl-1 1-1-pyrazol-4-yl)-2-(4-nitrobenzyl)-21 1-tetrazole; 5-(5-ch1oro-i-p1ieny1-1I1-pyrazo1-4-y)-2-(4-nitrobenzy1)-2H-tetrazo1e; 5-13-choro-1 -(2-cbiorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrohenzyl)-21-f-tetrazolc.; 5-[5-eh1oro--(2-chlorophenyl)-11-1-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-15-chloro-1 -(3-chlorophenyl)-11J-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazolc; 5-[5-chloro-1 -(3 -chlorophenyl)-I i-I-pyrazol-4-ylj-1 -(4-niftobenzyl)-2}-1-tetrazole; 5-[5-ch1oro-1-(4-ch1oropheny1)-1II-pyrazoI-4-yI]-2-(4-nitrobenzy1) 21-htetrazo1e; 5-[5 -chioro-I -(4-chlorophenyl)-1 H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazo Ic; 5-[5-chloro-1 -(2,3-dich1oropheny-I H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazole; 5-{5-chloro-1 -(2,3-dichlorophenyl)-1II-pyrazol-4-yl]-I -(4-nitrobenzyl)-21-I-telrazole; 5-[5-chloro-1-(2,4-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazole; 5-[5-chloro-I -(2,4-dichlorophenyl)-1H-pvrazol-4-yll-1-(4-nitrobenzyl)-2H-tctrazole; 5-[5-chloro-I -(2,5-dich]nrophcnyl)-I H-pyrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[5-chloro-1 -(2,5-dichIoropheny-1 H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazolc; 5-[5-chloro-1-(2,6-dichlorophenyl)-1H-pyrazol-4-yI]-2-(4-niirohenzyl) -21-1-tetrazole; 5-[3-chloro-I -(2,6-dichlorophenyl)-1iI-pyrazol-4-yfl-I -(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-I -(3,4-dichlorophenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl)-21-I-tetrazole: 5-[5-chloro-1-(3,4-dichlorophenyl)-1 H-pyrazol-4-ylj-1-(4-nitrobenzyl)-2H-tetrazole; 5-{5-chloro-I -(3,5-dich1oropheny1)-II1-pyrazoI-4-y1]-2-(-nitrobenzy1)-2H-tetrazo1e; 5-[5-chloro-I -(3,5-dichlorophenyl)-1H-pvrazol-4-yl]-1-(4-nitrobenzyl)-21-1-tetrazole; 5-[1 -(2-bromophenyl)-5-chloro-1 I-!-pyraz&-4-ylj-2-(4-nitrohenzvl)-2H-tetrazole; 5-[1 -(2-1rornopheny1)-5-ch1oro-1I-I-pyrazo1-4-yfl-I-(4-nitrohenzvI) -21-f-tefrazo1e; 5-{1 -(3-brornopheny1)-5-ch1oro-1H-pyrazo1-4-y1-2-(4-nitrohenzyI)-2H-tetrazo1e; 5-[1 -(3-bromophenyl)-5-chloro-I H-pyraz&-4-yfl-1 -(4-nitrobenzyl)-2H-tctrazole; 5-[1 -(4-bromopheriy1)-5-ch1oro-1H-pyrazo1-4-y1J-2-(4-nitrohenzy)-2H-tetrazo1e; 5-[ 1 -(4-bromophenyl)-5 -chioro-i J-1-pyrazol-4-yl] -I -(4-nitrobenzyl)-2H-tetrazolc; 5-[5-chloro-I -(4-fluorophenyl)-1H-pyrazol-4-yI]-2-(4-nItrobenzy])-2H-tetrazole; 5-[5-chloro-I -(4-fluorophenyl)-1H-pyrazol-4-yll-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2-fluorophenyl)-1H-pyrazol-4-yI]-2-(4-nitrobenzyl)-211-tetrazolc; 5-[5-chloro-1 -(2-fIuoropheny1)-1H-pyrazo1-4-y1-I -(4-nitrobenzy])-2H-tetrazole; 5-[5-ehloro-1 -(2.3-dimcthylphenyl)-1 H-pyrazol-4-yl]-2-(4-nitrohenzyl)-2H-tetrazole; 5-5-ch1oro-1 -(2.3-dimethylphenyl)-1 H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[5-ehloro-1-(2,4-dirnethylphenyl)-I H-pyrazol-4-yI]-2-(4-nilrobenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(2,4-dimethylphenyl)-1H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2.5-dimethylphenyl)-1 H-pyrazol-4-yi]-2-(4-nitrobenzyl)-2H4etrazole; 5-[5-ehloro-1 -(2,5-dimethypheny1)-1 H-pyraz&-4-yiJ-1-(4-nitrobenzyl)-2H-tetrazole; 5-[5-ehloro-1 -(2,6-dirnetbyiphenyl)-1I-I-pyrazol-4-ylj-2-(4-nitrobenzyl) -21-I-tetrazole; 5-[5-chloro-1-(2.6-dimethylphenvl)-1II-pyrazol-4-vfl-1-(4-nitrobenzyl) -21T-tetrazole; 5-[5-ehloro-1 -(3.4-dirnetbyiphenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-ehloro-I -(3,4-dimethy!phenyl)-I}-1-pyrazol-4-yl]-I -(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(3,5-dimethylphenyl)-IT-I-pyrazol-4-yl]-2-(4-nitrohenzyl)-21-T-tetrazole; 545-chioro-1 -(3,5-dimethylphenyl)-1H-pyrazol-4-yl]-1-(4-nitrobenzyl)-2F1-tetrazole; 5-[5-ehioro-1 -(2-ethyiphenyl)-IH-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(2-ethylphenyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-21-T-tetrazo!e; 5-[5-chloro-1 -(4-ethyiphenyl)-1H-pyrazol-4-yfl-2-(4-nitrobenzyl)-2F1-tctrazolc; 5-[5-cbloro-1 -(4-ethyiphenyl)-1ll-pyrazol-4-yfl-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-chloro-I -(4-methoxyphenyl)-I H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-chloro-1 -(4-methoxyphenyl)-1H-pyraz&-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-chloro-I -(2-rnethytphenyl)-1 H-pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetrazole; 5-{5-chloro-1 -(2-methylphenyl)-1T-1-pyrazol-4-yfl-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-chloro-1-(4-rnethylphenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl) -2H-tetrazole; 5-[5-chloro-1 -(4-methyiphenyl)-1 H-pyrazol-4-ylj-1 -(4-nitrobcnzyl)-2H-tetrazole; 5-(5-hromo-I -methyl-I t-1-pyrazol-4-y-2-(4-nitrohenzy-2I-T-tetrazole; 5-(5-brorno-1 -methyl-1I-i-pyrazol-4-yl)-1 -(4-nitrobenzyl)-21-I-tetrazole; 5-(5-bromo-1-ethyl-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-bronio--ethy'-I R-pyrazo!-4-y-I -(4-nitrobenzyl)-2H-tetrazo!e; 5-[5-bromo-l-(2-methylpropyl)-IT-1-pyrazol-4-y!]-2-(4-nitrobenzyl) -211-tctrazolc; 5-[5-brorno-1-(2-rnethylpropyl)-lJi-pyr'azol-4-yl]-1 -(4-nitrobenzy])-2T1-tetrazok; 5-( I -benzyl-5-brorno-I H-pyrazol -4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; S--benzyl-5-bromo-1II-pyrazol-4-yl)-1-(4-nitrobenzyl)-2H-tetrazole; 5-(5-bromo-I -phenyl-I H-pyrazol-4-yi)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(5-bromo-1 -phenyl-1H-pyrazol-4-yl)-1 -(4-nitrobenzyl)-21-I-tetrazcde; 5-[5-bromo-I -(2-chlorophenyl)-I H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-hromo-1 -(2-chlorophenyl)-1 H-pyrazol-4-yl]-I -(4-nitrohenzy)-2H-tetrazoIe; 5-[5-bronio-i-(3-chlorophenyl)-1II-pyrazol-4-yl]-2-(4-nitrobcnzyl) -2H-tctrazo!e: 5-[5-bromo-1-(3-chlorophenyl)-1 H-pyrazol-4-ylj-1-(4-nitrobenzyl)-211-tetrazole; 5-[5-bronio-I -(4-chiorophenyl)-1II-pyrazol-4-yl]-2-(4-nitrobcnzyl)-2H-tetrazo!e; 5-{5-brorno-1-(4-chlorophenyl)-I H-pyrazol-4-ylj-1 -(4-nitrobenzyl)-211-tetrazole; 5-{5-bromo-1 -(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1 -(2,3-dichlorophenyl)-1H-pyrazol-4-yl]-1-(4-nhrobenzyl)-21-I-tetrazolc; 5-[5-bromo-1-(2,4-dichlorophenyl)-1 H-pyrazol-4-yfl-2-(4-nitrobenzyl)-2}-1-tetrazole; 5-[5-bromo-1-(2,4-dichlorophenyl)-1 H-pyrazol-4-yl]-I-(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1-(2,5-dichlorophenyl)-1 I-{-pyrazo!-4-yF]-2-(4-nitrobenzyl)-2H-telrazole; 5-[5-brorno-1 -(2,5-dichlorophenyl)-1H-pyrazol-4-yl]-1-(4-nitrobenzyl)-211-tetrazolc; 5-{5-hromo-T -(2,6-dichlorophenyl)-1H-pvrazol-4-yl]-2-(4-nitrobenzyl)-211-tetrazole; 5-[5-bromo-1-(2,6-dichlorophenyl)-1 I-T-pyrazol-4-yI]-1 -(4-nitrobcnzyl)-2H4etrazole; 5-[5brorno-1 -(3,4-dichlorophenyl)-1II-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tctrazolc; 5-[5-bromo-l -(3,4-dichlorophenyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-21-I-tctrazolc; 5-{5-bromo-1-(3,5-dichlorophenyf)-H-pyrazol-4-ylj-2-(4-nitrobenzyl) -211-teirazole; 5-{5-bromo-1-(3,5-dichlorophenyl)-1H-pyrazol-4-yl]-1-(4-nitrobcnzyl) -2H-tetmzole: 5-[5-brorno--(2-bromophenyl)-1H-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazolc; 5-[5-brorno-1-(2-brornophenyl)-1H-pyrazol-4-yl]-1-(4-nitrobcnzyl) -2H-tetrazole; 5-[5-brorno--(3-bromophenyl)-1I-1-pyrazol-4-yfl-2-(4-nitrobenzyl) -2H-tetrazole; 5-{5-bromo-1-(3-bromophcnyl)-1H-pyrazol-4-yl]-1-(4-nitrohenzyl) -2H-tetrazole.; 5-[5-bromo-1-(4-bromophenyl)-1T-1-pyrazol-4-y1]-2-(4-nitrohcnzyl) -2H-tctrazolc; 5-[5-bromo-1 -(4-brornophenyl)-1H-pyrazol-4-ylj-1 -(4-nitrobenzyl)-211-tetrazole; 5-[5-bromo-1 -(4-tluorophenyl)-1 H-pyrazol-4-yl]-2-(4-nitrobenzyl)-21-I-tetrazole; 5-15-bromo-1-(4-fluorophenyl)-1 H-pyrazol-4-yl]-I -(4-nitrobenzyl)-2H-tctrazole; 5-[5-brorno-1-(2-fluorophenyl)-1FI-pyrazol-4-yli-2-(4-nitrohenzvl) -2T-I-tetrazo!e; 5-L5-bromo-1 -(2-fluorophenyl)-1 H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-hromo-1 -(2,3-dimethylphenyl)-I H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetra2ole; 5-[5-bromo-1 -(2,3-dirnethyiphenyl)-1IJ-pyrazol-4-yl]-1 -(4-nitrobenzyl)-21-1-tetrazole; 5-[5-bromo-1 -(2,4-dimethylphenyl)-1 H-pyrazol-4-ylj-2-(4-nitrobenzyl)-211-tetrazole; 5-15-bromo-1 -(2,4-dimethyiphenyl)-1H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-L5-bromo-I -(2,5-dirnethyiphenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl)-2H-tetrazolc; 5-[5-bromo-1-(2,5-dimethylphcnyl)-IH-pyrazol-4-yl]-1-(4-nitrobenzyl) -2H-tetrazole; 5-L5-bronio-I -(2,6-dirnethyiphenyl)-1Ii-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[5-bromo-1 -(2,6-dimethyiphenyl)-IH-pyrazol-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-i -(3,4-dinwthyp1ieny1)-1 H-pyrazo1-4-y1]-2-(4-nitrobenzy1)-2I-1-tetrw1e; 5-[5-bromo-l-(3,4-dimethylphcnyl)-IH-pyrazol-4-yl]-1 44-nitrobenzy-2H-tetrazoIe; 5-[5-bromo-1 -(3,5-diniethylphenyl)-l H-pyrazol-4-yl]-2-(4-nitrobenzyl)-21I-tetrazole; 5-[5-bromo-1-(3.5-dimcthylphcnyl)-IH-pyrazol-4-yl]-I -(4-nitrobenzy)-2H-tetrazole; 5-[5-bromo-I -(2-ethyiphenyl)-1H-pyrazol-4-ylj-2-(4-nitrobenzyl)-21-i-tetrazole; 5-[5-hromo-1 5-[5-bromo-1 -(4-ethyiphenyl)-1H-pyrazol-4-yll-2-(4-nitrohenzyl)-21-i-tetrazole; 5-[5-bromo-1-(4-ethylphenyl)-1I-1-pyrazol-4-yI]-1 -(4-nitrobenzyl)-21-1-tetrazole; 5-[5-brorno-1 -(4-methoxyphenyl)-iiI-pyrazol-4-yl]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[5-bromo-1 -(4-rnethoxyphenyl)-1H-pyrazol-4-vl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[5-brorno-1-(2-methylphenyl)-I H-pyrazol-4-yij-2-(4-nitrobenzyl)-2F1-tetrazoie; 5-[5-bromo-1 -(2-methylphenyl)-IH-pyrazol-4-yl]-l -(4-nitrobenzyl)-21-T-tetrazole; 5-[5-bromo-1 -(4-methylphenyl)-IH-pyrazol-4-yi]-2-(4-nitrobenzyl)-211-tctrazole; 5-[5-bromo-l -(4-methylphenyl)-1 H-pyrazol-4-yl]-1-(4-nifrobenzyl)-2H-tetrazole; 5-(5 -iodo-1-methyl-i H-pyrazol-4-yl)-2-(4-nitrohenzyl)-2H-tetrazole; 5-(5-iodo-I-methyl-lI-i-pyrazol-4-yl)-l-(4-nilrobenzyl)-2H-tetrazole; 5-(I -ethyl-5-iodo-1 H-pyrazol-4-yI)-2-(4-nitrobenzyl)-2H-tetrazole; 5-(1 -ethyl-5-iodo-1 H-pyrazol-4-yl)-t-(4-nhrobenzvl)-211-tettazole: 5-[5-iodo-i-(2-rncthylpropyl)-1 H-pyrazol-4-yl]-2-(4-nilrobenzyl)-2H-ietrazole; 5-[5-iodo-] -(2-methylpropyi)-iII-pyrazol-4-yl]-l-(4-nitrohenzyl)-2H-tetrazole; 5-(i-benzyl-5-iodo-1H-pyrazol-4-yl)-2-(4-nitrobenzyl)-2H-tetrazole; 5-0 -benzyl-5-iodo-I H-pyrazol-4-yl)-I -(4-nitrobenzyl)-2H-tetrazole; 5-(5-iodo-1 -phenyl-1l-I-pyrazo!-4-yI)-2-(4-nitrobenzyl)-2H-tetrazole; S -(5-iodo-I -phenyl-I H-pyrazol-4-yl)-1 -(4-nitrobenzyl)-21 1-tetrazole; 5-LI -(2-ehlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazoie; 5-[1 -(2-chlorophenyl)-5-iodo-I H-pyrazol-4-yIJ-I -(4-nitrobenzyi)-2H-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-1II-pyrazol-4-yfl-2-(4-nitrobcnzyl)-2H-tetrazole; 5-[1 -(3-chlorophenyl)-5-iodo-I FT-pyrazol-4-yI]-I -(4-nitrobenzyl)-2T1-tetrazole; 5-[I -(4-chlorophenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(4-chlorophenyl)-5-iodo-IH-pyrazol-4-yl]-1 -(4-nitrobenzyl)-211-tetrazole; 5-[1 -(2,3-diehlorophenyl)-5-iodo-1 H-pyrazol-4-y!]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[l -(2,3-dichlorophenyi)-5-iodo-ilI-pyrazol-4-ylI-i -(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(2.4-dichlorophenyl)-5-iodo-I H-pyrazol-4-yI]-2-(4-nitrobenzyl)-21-I-tetrazole; 5-fl -(2.4-dich1orophenyi)-5-iodo-11I-pyrazol-4-y1i-i-(4-nitrohenzyI) -2T-l-tctrao1c; 5-fl -(2,5-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yI]-2-(4-nitrobenzyl)-2H-tetrazolc; 5-[i-(2,5-dichlorophenyl)-5-iodo-1II-pyrazol-4-yll-l-(4-nitrobenzvl) -21i-tetrazole; 5-fl -(2,6-dichlorophenyl)-5-iodo-I H-pyrazol-4-yI]-2-(4-nitrobenzyi)-2H-tetrazolc; 5-[i -(2,6-dichlorophenyl)-5-iodo-1 Ii-pyrazol-4-yi]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-fl -(3,4-dichlorophenyl)-5-iodo-1 H-pyrazol-4-yl]-2-(4-nitrohenzyl)-2H-tctrazole; 5-[1 -(3,4-dich1oropheny)-5-iodo-lTi-pyrazo1-4-y1]-1 -(4-nitrobenzyl)-211-tetrazoie; 5-Li -(3,5-dichlorophenyi)-5-iodo-1i-i-pyrazol-4-yl]-2-(4-nitrobenzyl) -2H-tetrazole; 5-Li -(3,5-dichlorophenyl)-5-iodo-iII-pyrazol-4-yll-i -(4-nitrobenzyl)-2H-tetrazole; 5-Li -(2-bromophenyi)-5-iodo-i H-pyTazoi-4-yl]-2-(4-nitrobenzyl)-2H-letrazole; 5-[l -(2-brornophenyl)-5-iodo-1 H-pyrazol-4-yl]-I -(4-nitrohenzyl)-2H-tetrazole; 5-[i -(3-brornophenyl)-5-iodo-i II-pyrazol-4-yll-2-(4-nitrobenzyl)-2I1-tetrazole; 5-[i-(3-brornophenyl)-5-iodo-iH-pyrazol-4-yl]-1-(4-nilrobenzyl) -2H-tetrazole; 5-[i -(4-brornophenyl)-5-iodo-IH-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(4-brornophenyl)-5-iodo-1 i-I-pyrazol-4-yl]-1 -(4-nitrohenzy)-2H-tetrazo1e; 5-[1 -(4-fluorophcnyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[1-(4-fluorophenyl)-5-iodo-1 H-pyrazol-4-ylj-1 -(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(2-fiuorophenyl)-5-iodo-I H-pyrazo!-4-yl]-2-(4-nitrobcnzyi)-2H-tctrazolc; 5-{i -(2-t1uoropheny)-5-iodo-1 H-pyrazo]-4-yl]-I -(4-nitrobenzyl)-2H-tetrazole; 5-[i-(2,3-clirnethylphenyl)-5-iodo-1H-pyrazol-4-yl]-2-(4-nitrobcnzyl) -2H-tetrazole; 5-[1 -(2.3-dimethylphenyl)-5-iodo-1II-pyrazol-4-yll-i-(4-nitrobenzyi) -2H-tetrazole; 5-[i -(2,4-climethylphenyl)-5-iodo-1H-pyrazol-4-ylj-2-(4-nitrobenzyi) -214-tetrazole; 5-[i-(2,4-dimethylphenyl)-5-iodo-iH-pyrazol-4-yl]-I -(4-nitrobcnzyl)-2H-tetrazole; 5-LI -(2,5-dimethylphenyl)-5-iodo-1i-T-pyrazol-4-yI]-2-(4-nitrobenzyl) -21I-tetrazole; 5-ii-(2,5-dimethylphenyl)-5-iodo-1H-pyrazol-4-yl]-i-(4-nitrobenzyi) -2H-tetrazole; 5-Li-(2,6-dimethyiphenyl)-5-iodo-1H-pyrazoi-4-yl]-2-(4-thtrobenzyl) -2R-tetrazole; 5-L1-(2,6-dimethylphcnyl)-5-iodo-l H-pyrazol-4-yl]-1 -(4-nitrobenzyl)-21-I-tetrazole; 5-[1 -(3,4-dimetbylphenyl)-5-iodo-1 H-pyrazot-4-yl]-2-(4-nitrobcnzyi)-211-tetrazolc; 5-[1-(3,4-dimethylphenyi)-5-iodo-l ii-pyrazol-4-yfl-l -(4-nitrobenzyl)-2H-tetrazole; 5-[1 -(3,5-dirnethylphenyl)-5-iodo-1 H-pyrazol-4-yi]-2-(4-nitrobenzyl)-2H-tetrazole; 5-[i-(3,5-dimethyiphenyi)-5-iodo-iI-I-pyrazol-4-yij-1-(4-nitrobenzyl) -2H-tetrazole; 541 -(2-ethylphenyl)-5-iodo-I H-pyrazol -4-yl]-2-(4-nitrobenzyl)-2H-tctrazolc; 5-[i -(2-ethyiphenyi)-5-iodo-iH-pyrazoi-4-yl]-1 -(4-nitrobenzyl)-2H-tetrazole; 5-Li -(4-elhy]phenyl)-5-iodo-I H-pyrazol-4-yI]-2-(4-nitrohenzyl)-2H-tetrazole; 5-[1 -(4-ethylphenyl)-S-iodo-IH-pyrazol-4-yI]-1 -(4-nitrobenzyl)-21I-tetrazoie; 5-[5-iodo-1 -(4-methoxypheny)-1H-pyrazol-4-yll-2-(4-nitrobenzyl)-2H-tctrazole; 5-[5-iodo-1-(4-methoxyphenyl)-1 H-pyrazo1-4-yl]-l-(4-nitrobenzyl)2I-I4etrazo1e; 545-iodo-h(2-methylphenyl)-1 II-pyrazol-4-yfl-2-(4-nitrobcnzyl)-2H-tctrazolc; 5-[5-iodo-1 -(2-methylphenyl)-1 l-l-pyrazol-4-yl]-l-(4-nitrobenzyl)-2F1-tetrazole; 5-[5-iodo-1-(4-methylphenyl)-lH-pyrazol-4-ylI-2-(4-nitrobcnzyl) -2H-tctrazole; or 5-[5-iodo-I -(4-rneihylphenyl)-1H-pyrazol-4-yll-l-(4-nitrobenzyl)-2fl-tetrazole.
  7. 7. A process for preparing a compound of formula 1, its derivatives, salts, stereo-isomers or rcgio-isorners thereof,I \/Formula T wherein: R1 is selected from 1-1, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C17 allcyl; wherein said alkyl is optionally substituted with phenyl group; and the substitucnt when present in the phenyl group is one or more substituent independently selected from Cl, Br, F, I, NO2, CN. Ci5 alkyl, phenyl, or a C1-C4 alkoxy; R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain akyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a alkoxy; said process comprising: N, / N.. N Formula II treating a compound of formula II with a reagent and an organic solvent selected from N,N-dimcthylformamidc, N,N-dimethylacetaniide, N-methyl-2-pyrrolidone, acetonitTile, acetone, dichloromcthanc, 1.2-dichloroethane, methanol, tetrahydrofuran, toluene, xylcne, bcnzcnc or water to obtain a compound of formula I with R2 as hydrogen, its derivatives, salts, stereo-isomers, or regio-isomers thereof; wherein.Ri is selected from II, Cl, Br or I; R3 is sclcctcd from a straight or a branchcd chain C17 ailcyl; or a C6-C14 my' group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C1.5 alkyl, phenyl, or a C1-C4 alkoxy; and said reagent is selected from an optionally substituted sodium azide in the presence of either an ainmonium halide such as ammonium chloride, ammonium bromide or ammoniurn iodide or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-butyl tin bromide or tri-n-butyl tin iodide; and optionally alkylating the above compound of formula I with a dialkyl sulfate or alkali halide such as methyl iodide or methyl bromide, in presence of a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate. potassium carbonate or cesium carbonate; or an organic base such as triethyl amine. di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-din-iethy]aniline. to obtain a compound of formula I, its derivatives, salts, stereo-isomers, or rcgio-isomers thereof, wherein R2 is selected from a straight chain or a branched C alkyl.
  8. 8. The process as claimed in claim 7, said process comprising: treating a compound of foimula II with an optionally substituted sodium azide in the presence of either an ammonium halide such as ammonium chloride, ammonium bromide or ammonium iodide, and a polar solvent selected from N,N-dimethylformarnide, N,N-dimethylacetamide, N-methyl -2-pyrrol idone or water; or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-butyl tin bromide or tn-n-butyl tin iodide in presence of a non polar solvent such as toluene. xylene or bcnzcnc, to obtain a compound of formula I, wherein R2 is hydrogen.
  9. 9. The process as claimed in claim 7, comprising: /NON Formula III treating a compound of formula ITT with sodium nitrite and cuprous halide selected from euprous chloride, cuprous bromide or cuprous iodide, with a mineral acid selected from hydrochloric acid. hydrobromic acid, or sulfuric acid, to obtain a compound of formula II; wherein R3 is selected from a straight or a branched chain C1.7 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C1.5 allcyl, phenyl, or a C1-C4 alkoxy; and treating the compound of formula II with a substituted sodium azide in the presence of either an ammonium halide such as ammoniuni chloride, ammonium bromide or ammonium iodide; and a polar solvent selected from N,N-dirnethylformarnide, N.N-dimethylacetamide, N-methyl-2-pyrrolidonc, or water, or a tri-n-hutyl tin halide such as tri-n-hutyl tin chloride, tri-n-butyl tin bromide or tn-n-butyl tin iodide in presence of a non polar solvent such as toluene. xylene or benzene, to obtain the compound of formula I. its derivatives, salts, stereo-isomers, regio-isomers thereot wherein R2 is hydrogen.
  10. 10. The process as claimed in claim 7, comprising: treating malononitrile with a compound of fornmla V in presence of acetic auhydride to obtain a compound of formula IV; NcR4 Formula V, Formula IV wherein R4 is independently selected from a straight or a branched C alkyl; treating the compound of formula IV with an optionally substituted N-alkyl hydrazine sulfate, or an optionally substituted N-alkyl hydrazine, or an optionally substituted N-aryl hydrazine sulthte, or an optionally substituted N-aryl hydrazine, and a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonatc; or an organic base such as triethyl amine, di-isopropyl amine. di-isopropyl ethyl amine, s pyridine, pyrrolidine or N,Ndimethy1aniline, in the presence of an alcohol selected from methanol, ethanol or propanol to obtain a compound of formula III, Fk, /N H2Formula III wherein R3 is selected from a straight chain or a branched chain C14 alkyl or a C6 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more phenyl group; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, C12 alkyl, phcnyl or C 1-C4 allcoxy; treating the compound of formula III with sodium nitrite and cuprous halide selected from cuprous chloride, cuprous bromide or cuprous iodide, with a mineral acid selected from hydrochloric acid, hydrobromic acid, or sulfuric acid, to obtain a compound of formula II; treating the compound of formula TI with sodium azide in the presence of either an animonium halide selected from ammonium chloride, ammonium bromide or ammonium iodide; and a polar solvent selected from N,N-dimethylformamide, N,N-dimethylacetarnide, N-methyl-2-pyrrolidonc, or water, or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-hutyl tin bromide or tri-n-butyl tin iodide in presence of a non poiar solvent such as toluene, xylene or benzene. to obtain a compound of formula I, its derivatives, salts, stereo4somers, regio-isomers thereof wherein ft2 is hydrogen.
  11. 11. The process as claimed in claim 7, said process comprising: treating a compound of formula II with an optionally substituted sodium azide in the presence of either an ammonium halide such as ammonium chloride, ammonium bromide or ainmonium iodide, and a polar solvent selected from N,N-dimethylformarnide, N,N-dimethylacetarnide, N-methyl-2-pyrrolidone, or water; or a tri-n-butyl tin halide such as tri-n-butyl tin chloride, tri-n-hulyl tin bromide or tn-n-butyl tin iodide in presence of non poiar solvent such as toluene, xylene or benzene, to obtain a compound of formula I wherein R2 is hydrogen; and alkylating the above compound of formula I with a dialkyl sulfate, or alkyl halide such as methyl iodide or methyl bromide in presence of a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-dirnethylaniline, in the presence of a polar solvent N,N-dimethylformamide, N,N-diniethylaeetamide, N-methylpyrrolidone, acetonitrile, acetone, dichloroinethane, l,2-dichloroethane, methanol. tetrahydrofuran or water, to obtain a compound of fonmila I wherein R2 is selected from a straight chain or a branched C17 alkyl.
  12. 12. The process as claimed in claim 10, further comprising: alkylating a compound of formula I wherein R2 is hydrogen with dialkyl sulfate or alkyl halide such as methyl iodide or methyl bromide and a base selected from an alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or an organic base such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine, pyridine, pyrrolidine or N,N-din-iethylaniline, in the presence of a polar solvent N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, acetonitrile, acetone, dichloromethane, l,2-diehloroethane. methanol, tetrahydrofuran or water, to obtain a compound of formula I wherein R2 is a straight chain or a branched C17 alkyl.
  13. 13. The process as claimed in claim 7, said process comprising: treating 5 -chloro-1-methyl-1 H-pyrazole-4-carbonitrile compound with sodium azide in the presence of either amnionium chloride, and N,N-dimethylformamide, or tri-n-butyl tin chloride and toluene to obtain the 5-(5-chloro-1-rnethyl-IH-pyrazol-4-yl)-211-tetrazole) of formula 1, wherein R2 is H.
  14. 14. The process as claimed in claim 7, said process comprising: treating 5-ehloro-l-methyl-l [I-pyrazole-4-carhonitrile compound with sodium azide in the presence of either ammonium chloride, and N,N-dimethylformamidc: or tri-n-hutyl tin chloride and toluene to obtain 5-(5-chloro-1 -mcthyl-IH-pyrazol-4-yl)- 2H-tetrazole of formula I; wherein R2 is hydrogen; and methylating 5-(5-chloro-I -methyl-I H-pyrazol-4-yl)-211-tctrazolc) of formula I; wherein R2 is hydrogen; with dirnethyl sulfate and potassium carbonate in the presence of acetone, to obtain 5-(5-chloro-1-methyl-1II-pyrazol-4-y-2-methyl-2H-tetrazolc of formula I; wherein R2 is a methyl.
  15. 15. A process for preparing a compound of formula I, its derivatives, salts, stereo-isomers or regio-isomers thereof, N\ /ç\-R,NUYFormula I wherein: R1 is selected from Fl, Cl, Br or I; R2 is selected from hydrogen or a straight chain or a branched C17 alkyl; wherein said alkyl is optionally substituted with phenyl group; and the substituent when present in the phenyl group is one or more substituent independently selected from Cl, Br, F, I, NO2, CN. C15 alkyl, phenyl, or a Ci-C3 alkoxy; R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C5 alkyl, phenyl, or a C1-C4 alkoxy; said process comprising: reacting a compound of formula VII with an alkylating agent such as alkyl halide, or dialkyl sulfate in the presence of a base selected from alkali metal hydroxide base, such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base such as sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; or organic bases such as triethyl amine, di-isopropyl amine, di-isopropyl ethyl amine. pyridine, pyrrolidine or N,N-dimethylaniline, to obtain a compound of formula VI; N\I Formula VII Formula VI wherein: R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; said straight or branched chain alkyl is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, or phenyl; said aryl group is optionafly substituted with one or more substituent indepcndcntly sclcctcd from CI. Br, F, I, C5 alkyl, phcnyl. or a C -C4 alkoxy; and halogenating the compound or forniuin VI with a halogenating agent selected from N-chlorosuccinimide, N-bromosuccinin-iide or N-iodosuccinirnidc in thc presence of polar solvent selected from N,N-dimethylformamide, N,N-dirnethylacetarnide, N-meLhyl-2-pyrrolidone, acetonitrile, acetone, dichloromethane, l,2-dichloroethane. methanol. tetrahydrofuran, ethyl acetate, or butyl acetate, to obtain the compound of formula I.
  16. 16. The process as claimed in claim IS, wherein said compound of formula VII is prcpared by a process comprising: treating a compound of formula X with phosphoryl chloride in the presence of a p&ar solvent s&ected from N,N-dimethylformamide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone, acetonitri Ic, dichlorornethane, I,2-dichloroethane, or tetrahydrofuran, to obtain a compound of formula IX; Rs / / N / N0 rHO Formula X Formula IX wherein: R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; said straight or branched chain alkyl is optionally substituted with one or morc substitucnt independently selected from Cl, Br, F, I, or phenvi; said aryi group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy; treating the compound of formula IX with hydroxyl amine hydrochloride in the presence of an alcohol selected from methanol, ethanol or propanol, to obtain a S compound of formula VIII; and /N N Li \ OHN Formula VIII treating the compound of formula VIII with sodium azide in the presence of anirnonium chloride and a polar solvent selected from N,N-dimethylfornrnrnide, N,N-dimethylacetamide, N-methyl-2-pyrrolidone,tetrahydrofuran or water, to obtain the compound of formula Vii.
  17. 17. The process as claimed in claim 15. wherein said compound of formula VII is prepared by a process comprising: treating a compound of formula X with iodine and a strong oxidizing agent such as hydrogen peroxide in aqueous medium to obta.in a compound of formula XII; / N\I 0Formula X Formula XII wherein: R3 is selected from a straight or a branched chain C17 alkyl; or a C6-C14 aryl group; wherein said straight or branched chain alkyl is optionally substituted with one or more substituent independently selecled from Cl, Br, F, I, or phenyl; said aryl group is optionally substituted with one or more substituent independently selected from Cl, Br, F, I, C15 alkyl, phenyl, or a C1-C4 alkoxy; treating the compound of formula XII with either potassium lerrocyanide and palladium (II) acetate in the presence of a base sclcctcd from alkali metal hydroxide base such as sodium hydroxide, potassium hydroxide or lithium hydroxide; or an alkali metal carbonate base selected from sodium carbonate, sodium bicarbonate, potassium carbonate or cesium carbonate; and a polar solvent selected from N,N-dimethylforrnamide, N,N-dimethylacetarnide, n-rnethyl-2-pyrrolidone, acetonitrile, acetone, diehloromethane, I,2-di chloroethane. methanol, tetrahydrofuran or water; or sodium cyanide or copper cyanide in the presence of euprous halides such as cuprous iodide and N,N-dimethyl ethylene diamine with a non polar solvent such toluene, xylene, or benzene, to obtain a compound of formula XI; and /NNRFormula XI treating the compound of formula Xl with sodium azide and either tri-n-hutyl tin chloride in the presence of a non polar solvent selected from toluene, xylene or henzene; or ammonium chloride and N.N-diinethylformamide, to obtain the compound of formula VII.
  18. 18. The process as claimed in claim 15 for preparing a compound of formuLa 1, its derivatives, salts, stereo-isomers or regio-isomers thereof, comprising reacting 5-( 1-methyl-I H-pyrazol-4-yl)-2J1-tetrazole with methyl iodide and dimethyl sulphate, in the presence of potassium hydroxide and potassium carbonate to obtain 2-methyl-5-(1 -methyl-I H-pyrazol-4-yl)-2H-tetrazole; and chlorinating 2-mcthyl-5-(l -methyl-1 H-pyrazol-4-yl)-2H-tetrazole with N- chiorosuecinimide, in the presence aeetonitri Ic, to obtain 5-(5 -ehioro-1-methyl-1H-pyrazol-4-yl)-2-rnethyl-2H-tetrazole of formula I.
  19. 19. The process as claimed in claim 15, for preparing a compound of formula I, its derivatives. salts, stereo-isomers or regio-isomers thereof, comprising treating 1-methyl-I H-pyrazole with phosphoryl chloride in the presence of N,N-dimethylformamide, to obtain I-methyl-I T1-pyrazole-4-earbaldehyde; treating the 1 -methyl-I H-pyrazole-4-carbaldehyde with hydroxylamine hydrochloride in the presence of ethanol, to obta.in 1-niethyl-IH-pyrazole-4-earbaldehyde oxime; treating the i-methyl-iH-pyrazole-4-carhaldehyde oxime with sodium azide in the presence of ammoniuni chloride and N,N-dimethyiformamide, to form the 5-(i-methyl-1H-pyrazoi-4-yl)-2H-tctrazole; reacting 5-(l-methyl-1H-pyrazole-4-yl)-2H-tetrazole with methyl iodide and dimethyl sulphate, in the presence of potassium hydroxide and potassium carbonate to obtain 2-methyl-S -(1-methyl-i H-pyrazol-4-y-2fJ-tetrazo1e; and chlorinating 2-methyl-5-( I -methyl-1H-pyrazole-4-yi)-2H-tetrazole with N- chlorosuccinimide, in the presence acetonitrile, to obtain 5-(5-chloro-l-methyl-IH-pyrazol-4-yl)-2-methyl-2H-tetrazole of formula I.
  20. 20. The process as claimed in claim 15, for preparing a compound of formula 1, its derivatives, salts, stereo-isomers or regio-isomers thereoi comprising treating I -methyl-IH-pyrazole with iodine and hydrogen peroxide in aqueous medium to obtain 4-iodo-i-methyl-1H-pyrazole; treating the 4-iodo-1-methyl-li/-pyrazo!e with potassium ferrocyanide and palladium (II) acetate in the presence of sodium carbonate, and N,N-dimethylacetamide, to obtain 1-methyl-lH-pyrazole-4-carbonitrile; treating the 1-methyl-I N-pyrazole-4-carbonitrile with sodium azide and either with tri-n-butyl tin chloride in the presence of toluenc, or ammonium chloride in the presence of N,N-dimethylformamide to obtain the 5-( 1-methyl-1H-pyrazol-4-yl)-2L1-tctrazolc; reacting S-(1 -methyl-1H-pyrazol-4-yl)-2H-tetrazole with methyl iodide arid dimethyl sulphate, in the presence of potassium hydroxide and potassium carbonate to obtain 2-methyl-5-( I-methyl-lH-pyrazol-4-yl)-2H-tetrazole; and chlorinating 2-methyl-S -O -methyl-I II-pyrazol-4-yl)-211-tetrazol e with N- chlorosuccinimide, in the presence acetonitrile, to obtain S-(5-chloro-1-methyl-1H-pyraol-4-yl)-2-methyl-2H-tetrazole of formula I.
GB201215178A 2012-08-24 2012-08-24 Tetrazole compounds useful as intermediates for the preparation of herbicides Withdrawn GB2503524A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999006380A1 (en) * 1997-08-01 1999-02-11 Nissan Chemical Industries, Ltd. Tetrazole compounds and pest control agent
JPH1180137A (en) * 1997-07-10 1999-03-26 Nissan Chem Ind Ltd Carbamoyltetrazole and herbicide

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1180137A (en) * 1997-07-10 1999-03-26 Nissan Chem Ind Ltd Carbamoyltetrazole and herbicide
WO1999006380A1 (en) * 1997-08-01 1999-02-11 Nissan Chemical Industries, Ltd. Tetrazole compounds and pest control agent

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Title
"Chemical properties of derivatives of N-difluoromethyl- and N-2-H-tetrafluoroethylpyrazoles", Chemistry of Heterocyclic Compounds (New York, NY, United States) (2006), 42(9), 1177-1184, Petko et al. *
Aurora Screening Library (Catalogue; published 30 Jan 2012), Order Number K11.067.238, CAS Registry No. 1334649-96-5. *
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