RU2001129097A - Способ получения n-ацил-3,4-дегидропролина и производных -ацил-3,4-дегидропиперидин-2-карбоновых кислот - Google Patents
Способ получения n-ацил-3,4-дегидропролина и производных -ацил-3,4-дегидропиперидин-2-карбоновых кислотInfo
- Publication number
- RU2001129097A RU2001129097A RU2001129097/04A RU2001129097A RU2001129097A RU 2001129097 A RU2001129097 A RU 2001129097A RU 2001129097/04 A RU2001129097/04 A RU 2001129097/04A RU 2001129097 A RU2001129097 A RU 2001129097A RU 2001129097 A RU2001129097 A RU 2001129097A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- carbon atoms
- acyl
- general formula
- dehydropiperidine
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 6
- 239000001257 hydrogen Substances 0.000 claims abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract 6
- 150000001875 compounds Chemical class 0.000 claims abstract 5
- 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims abstract 3
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims 7
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 125000000217 alkyl group Chemical group 0.000 claims 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 239000002585 base Substances 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 239000007795 chemical reaction product Substances 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 239000000460 chlorine Substances 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- DWKUKQRKVCMOLP-UHFFFAOYSA-N 1-piperideine Chemical compound C1CCN=CC1 DWKUKQRKVCMOLP-UHFFFAOYSA-N 0.000 claims 1
- OMGHIGVFLOPEHJ-UHFFFAOYSA-N 2,5-dihydro-1h-pyrrol-1-ium-2-carboxylate Chemical compound OC(=O)C1NCC=C1 OMGHIGVFLOPEHJ-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 229910052783 alkali metal Inorganic materials 0.000 claims 1
- -1 alkali metal amide Chemical class 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Chemical group BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 229910002092 carbon dioxide Inorganic materials 0.000 claims 1
- 239000001569 carbon dioxide Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000007062 hydrolysis Effects 0.000 claims 1
- 238000006460 hydrolysis reaction Methods 0.000 claims 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical group II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims 1
- 150000003236 pyrrolines Chemical class 0.000 claims 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006823 (C1-C6) acyl group Chemical group 0.000 abstract 1
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
- Pyrrole Compounds (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19913699.8 | 1999-03-26 | ||
| DE19913699A DE19913699A1 (de) | 1999-03-26 | 1999-03-26 | Verfahren zur Herstellung von 3,4-Dihydroprolinen und 3,4-Dehydropiperidinen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2001129097A true RU2001129097A (ru) | 2004-03-20 |
Family
ID=7902464
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2001129097/04A RU2001129097A (ru) | 1999-03-26 | 2000-03-17 | Способ получения n-ацил-3,4-дегидропролина и производных -ацил-3,4-дегидропиперидин-2-карбоновых кислот |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US6579971B1 (https=) |
| EP (1) | EP1165509B1 (https=) |
| JP (1) | JP3868210B2 (https=) |
| KR (1) | KR20010104730A (https=) |
| CN (1) | CN1345310A (https=) |
| AT (1) | ATE278665T1 (https=) |
| AU (1) | AU3962500A (https=) |
| BR (1) | BR0009330A (https=) |
| CA (1) | CA2368479C (https=) |
| CZ (1) | CZ20013456A3 (https=) |
| DE (2) | DE19913699A1 (https=) |
| ES (1) | ES2230088T3 (https=) |
| HK (1) | HK1045156A1 (https=) |
| HU (1) | HUP0200420A2 (https=) |
| IL (1) | IL145525A0 (https=) |
| MX (1) | MXPA01009679A (https=) |
| NO (1) | NO20014645L (https=) |
| RU (1) | RU2001129097A (https=) |
| TR (1) | TR200102747T2 (https=) |
| TW (1) | TWI276626B (https=) |
| WO (1) | WO2000058284A1 (https=) |
| ZA (1) | ZA200107629B (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100396666C (zh) * | 2005-12-14 | 2008-06-25 | 郑州大学 | （4s）-1-叔丁氧羰基-4-氨基-l-脯氨酸乙酯及其合成工艺 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4291040A (en) * | 1979-10-22 | 1981-09-22 | E. R. Squibb & Sons, Inc. | Mercaptoacyl derivatives of 4-disubstituted prolines and 4-substituted dehydroprolines |
| US5580575A (en) | 1989-12-22 | 1996-12-03 | Imarx Pharmaceutical Corp. | Therapeutic drug delivery systems |
| AU7655194A (en) | 1993-09-09 | 1995-03-27 | Schering Aktiengesellschaft | Active principles and gas containing microparticles |
| DE19630082A1 (de) * | 1996-07-26 | 1998-01-29 | Basf Ag | Verfahren zur Herstellung von 3-Pyrrolin-2-carbonsäure-Derivaten |
| US6090800A (en) | 1997-05-06 | 2000-07-18 | Imarx Pharmaceutical Corp. | Lipid soluble steroid prodrugs |
| DE19723473A1 (de) * | 1997-06-04 | 1998-12-10 | Basf Ag | Verfahren zur Herstellung von chiralen 3,4-Didehydroprolinen |
| JP4772958B2 (ja) | 1998-02-09 | 2011-09-14 | ブラッコ・リサーチ・ソシエテ・アノニム | 生物学的に活性な媒質の標的に向けた送達 |
-
1999
- 1999-03-26 DE DE19913699A patent/DE19913699A1/de not_active Withdrawn
-
2000
- 2000-03-09 TW TW089104251A patent/TWI276626B/zh not_active IP Right Cessation
- 2000-03-17 MX MXPA01009679A patent/MXPA01009679A/es unknown
- 2000-03-17 CA CA002368479A patent/CA2368479C/en not_active Expired - Fee Related
- 2000-03-17 EP EP00918809A patent/EP1165509B1/de not_active Expired - Lifetime
- 2000-03-17 AU AU39625/00A patent/AU3962500A/en not_active Abandoned
- 2000-03-17 HK HK02106153.8A patent/HK1045156A1/zh unknown
- 2000-03-17 BR BR0009330-0A patent/BR0009330A/pt not_active IP Right Cessation
- 2000-03-17 KR KR1020017012187A patent/KR20010104730A/ko not_active Abandoned
- 2000-03-17 CZ CZ20013456A patent/CZ20013456A3/cs unknown
- 2000-03-17 ES ES00918809T patent/ES2230088T3/es not_active Expired - Lifetime
- 2000-03-17 US US09/937,312 patent/US6579971B1/en not_active Expired - Lifetime
- 2000-03-17 HU HU0200420A patent/HUP0200420A2/hu unknown
- 2000-03-17 RU RU2001129097/04A patent/RU2001129097A/ru unknown
- 2000-03-17 CN CN00805579A patent/CN1345310A/zh active Pending
- 2000-03-17 IL IL14552599A patent/IL145525A0/xx unknown
- 2000-03-17 JP JP2000607987A patent/JP3868210B2/ja not_active Expired - Fee Related
- 2000-03-17 DE DE50008117T patent/DE50008117D1/de not_active Expired - Fee Related
- 2000-03-17 WO PCT/EP2000/002377 patent/WO2000058284A1/de not_active Ceased
- 2000-03-17 AT AT00918809T patent/ATE278665T1/de not_active IP Right Cessation
- 2000-03-17 TR TR2001/02747T patent/TR200102747T2/xx unknown
-
2001
- 2001-09-17 ZA ZA200107629A patent/ZA200107629B/en unknown
- 2001-09-25 NO NO20014645A patent/NO20014645L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20014645D0 (no) | 2001-09-25 |
| CA2368479A1 (en) | 2000-10-05 |
| ZA200107629B (en) | 2002-09-17 |
| BR0009330A (pt) | 2002-01-08 |
| WO2000058284A1 (de) | 2000-10-05 |
| KR20010104730A (ko) | 2001-11-26 |
| MXPA01009679A (es) | 2002-03-14 |
| EP1165509A1 (de) | 2002-01-02 |
| DE50008117D1 (de) | 2004-11-11 |
| DE19913699A1 (de) | 2000-09-28 |
| TR200102747T2 (tr) | 2002-02-21 |
| JP3868210B2 (ja) | 2007-01-17 |
| US6579971B1 (en) | 2003-06-17 |
| CN1345310A (zh) | 2002-04-17 |
| AU3962500A (en) | 2000-10-16 |
| EP1165509B1 (de) | 2004-10-06 |
| JP2002540190A (ja) | 2002-11-26 |
| TWI276626B (en) | 2007-03-21 |
| NO20014645L (no) | 2001-09-25 |
| CZ20013456A3 (cs) | 2002-05-15 |
| HUP0200420A2 (hu) | 2002-05-29 |
| HK1045156A1 (zh) | 2002-11-15 |
| ES2230088T3 (es) | 2005-05-01 |
| CA2368479C (en) | 2005-03-01 |
| IL145525A0 (en) | 2002-06-30 |
| ATE278665T1 (de) | 2004-10-15 |
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