RU2001123684A - METHOD OF DRYING CRYSTALS OF PROTEINS - Google Patents

METHOD OF DRYING CRYSTALS OF PROTEINS

Info

Publication number
RU2001123684A
RU2001123684A RU2001123684/04A RU2001123684A RU2001123684A RU 2001123684 A RU2001123684 A RU 2001123684A RU 2001123684/04 A RU2001123684/04 A RU 2001123684/04A RU 2001123684 A RU2001123684 A RU 2001123684A RU 2001123684 A RU2001123684 A RU 2001123684A
Authority
RU
Russia
Prior art keywords
solvent
protein crystals
drying
paragraphs
inclusive
Prior art date
Application number
RU2001123684/04A
Other languages
Russian (ru)
Other versions
RU2235730C2 (en
Inventor
Рольф ДОЙССЕР
Петер КРЕМЕР
Хорст ТУРОВ
Original Assignee
Авентис Фарма Дойчланд Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19903125A external-priority patent/DE19903125B4/en
Application filed by Авентис Фарма Дойчланд Гмбх filed Critical Авентис Фарма Дойчланд Гмбх
Publication of RU2001123684A publication Critical patent/RU2001123684A/en
Application granted granted Critical
Publication of RU2235730C2 publication Critical patent/RU2235730C2/en

Links

Claims (13)

1. Способ сушки кристаллов протеинов, исходя из водной суспензии кристаллов протеинов, отличающийся тем, что суспензию кристаллов протеинов сушат в центробежной сушилке.1. The method of drying protein crystals, based on an aqueous suspension of protein crystals, characterized in that the suspension of protein crystals is dried in a centrifugal dryer. 2. Способ по п. 1, отличающийся тем, что кристаллы протеинов после их отфильтровывания из суспензии кристаллов протеинов помещают в сушильную среду, состоящую из смеси воды и неводного, смешиваемого с водой в любом соотношении растворителя, который обладает более низким давлением пара, чем вода.2. The method according to p. 1, characterized in that the protein crystals after they are filtered from a suspension of protein crystals are placed in a drying medium consisting of a mixture of water and non-aqueous, mixed with water in any ratio of a solvent that has a lower vapor pressure than water . 3. Способ по п. 2, отличающийся тем, что доля растворителя в сушильной среде составляет от включительно 10 до включительно 80%.3. The method according to p. 2, characterized in that the proportion of solvent in the drying medium is from inclusive 10 to inclusive 80%. 4. Способ по п. 3, отличающийся тем, что доля растворителя в сушильной среде составляет от включительно 15 до включительно 60%.4. The method according to p. 3, characterized in that the proportion of solvent in the drying medium is from inclusive 15 to inclusive 60%. 5. Способ по одному из пп. 2-4, отличающийся тем, что растворителем является спирт или смесь спиртов.5. The method according to one of paragraphs. 2-4, characterized in that the solvent is an alcohol or a mixture of alcohols. 6. Способ по п. 5, отличающийся тем, что растворителем является метанол.6. The method according to p. 5, characterized in that the solvent is methanol. 7. Способ по п. 5 или 6, отличающийся тем, что растворителем является этанол.7. The method according to p. 5 or 6, characterized in that the solvent is ethanol. 8. Способ по одному из пп. 5-7, отличающийся тем, что растворителем является н-пропанол.8. The method according to one of paragraphs. 5-7, characterized in that the solvent is n-propanol. 9. Способ по одному из пп. 5-8, отличающийся тем, что растворителем является изопропанол.9. The method according to one of paragraphs. 5-8, characterized in that the solvent is isopropanol. 10. Способ по одному из пп. 1-9, отличающийся тем, что используют сушильный газ, который перед процессом сушки увлажняют водой.10. The method according to one of paragraphs. 1-9, characterized in that they use a drying gas, which is moistened with water before the drying process. 11. Способ по п. 10, отличающийся тем, что сушильным газом является азот.11. The method according to p. 10, characterized in that the drying gas is nitrogen. 12. Способ по одному из пп. 1-11, отличающийся тем, что кристаллы протеинов после отфильтровывания их из суспензии кристаллов протеинов для сушки переводят в псевдоожиженный слой.12. The method according to one of paragraphs. 1-11, characterized in that the protein crystals after filtering them from a suspension of protein crystals for drying are transferred to the fluidized bed. 13. Способ по одному из пп. 1-12, отличающийся тем, что кристаллами протеинов являются кристаллы животного инсулина, человеческого инсулина или один из их аналогов.13. The method according to one of paragraphs. 1-12, characterized in that the protein crystals are crystals of animal insulin, human insulin or one of their analogues.
RU2001123684/04A 1999-01-27 2000-01-15 Method for drying protein crystals RU2235730C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19903125A DE19903125B4 (en) 1999-01-27 1999-01-27 Process for drying crystals of insulin or insulin analogues
DE19903125.8 1999-01-27

Publications (2)

Publication Number Publication Date
RU2001123684A true RU2001123684A (en) 2003-06-20
RU2235730C2 RU2235730C2 (en) 2004-09-10

Family

ID=7895502

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001123684/04A RU2235730C2 (en) 1999-01-27 2000-01-15 Method for drying protein crystals

Country Status (20)

Country Link
US (1) US6408536B1 (en)
EP (1) EP1185548B1 (en)
JP (1) JP4465120B2 (en)
KR (1) KR100652471B1 (en)
CN (1) CN1211397C (en)
AT (1) ATE323101T1 (en)
AU (1) AU764353B2 (en)
BR (1) BRPI0007713B8 (en)
CA (1) CA2361397C (en)
CY (1) CY1105256T1 (en)
CZ (1) CZ300915B6 (en)
DE (2) DE19903125B4 (en)
DK (1) DK1185548T3 (en)
ES (1) ES2259994T3 (en)
HK (1) HK1044548B (en)
HU (1) HU226697B1 (en)
PL (1) PL197694B1 (en)
PT (1) PT1185548E (en)
RU (1) RU2235730C2 (en)
WO (1) WO2000044767A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19903125B4 (en) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Process for drying crystals of insulin or insulin analogues
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
DE102004049241A1 (en) * 2004-10-09 2006-04-20 Sanofi-Aventis Deutschland Gmbh Dryers and method for controlling a dryer
EP1870649A1 (en) 2006-06-20 2007-12-26 Octapharma AG Lyophilisation targetting defined residual moisture by limited desorption energy levels
US20090271021A1 (en) * 2008-04-28 2009-10-29 Popp Shane M Execution system for the monitoring and execution of insulin manufacture
CA2855726A1 (en) 2011-11-16 2013-05-23 Bayer Intellectual Property Gmbh Device for filtration, drying and storage
MX2020004042A (en) * 2017-09-26 2021-01-15 Biocon Biologics India Ltd Integrated automated filtration for separation, washing and drying of peptide crystals.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139637A (en) * 1972-12-28 1979-02-13 Maurice Rouchy Quinone derivatives useful as medicaments
US4133716A (en) * 1976-11-22 1979-01-09 Crc Compagnia Ricerca Chimca, S.A. Method for the biosynthesis of a microbial insecticide
US5234503A (en) * 1987-02-02 1993-08-10 A.E. Saley Manufacturing Co. Integrated process for producing crystalline fructose and a high-fructose, liquid-phase sweetener
DE3717370A1 (en) * 1987-05-22 1988-12-01 Hoechst Ag MIXED CRYSTALS FROM INSULIN AND INSULINE DERIVATIVES, METHOD FOR THE PRODUCTION OF THESE MIXED CRYSTALS, PHARMACEUTICAL AGENTS CONTAINING THESE MIXED CRYSTALS AND THEIR USE FOR TREATING DIABETES MELLITUS
DE4013388A1 (en) * 1990-04-26 1991-10-31 Titus Hans Joachim CENTRIFUGAL DRYER
US5526581A (en) * 1992-10-30 1996-06-18 Philip Morris Incorporated Process for adjusting the moisture content of organic materials
DE59409816D1 (en) * 1993-04-27 2001-09-13 Hoechst Ag Amorphous monospheric forms of insulin derivatives
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5544425A (en) * 1995-05-17 1996-08-13 Mallinckrodt Medical, Inc. Aggressive convective drying in a nutsche type filter/dryer
GB9522302D0 (en) * 1995-10-31 1996-01-03 Univ Liverpool Growth promoters
US5932212A (en) 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
US5743840A (en) * 1996-06-24 1998-04-28 Carr Separations, Inc. Centrifuge with a heating jacket for drying collected solids
CA2283705A1 (en) * 1997-03-20 1998-10-01 Novo Nordisk A/S Zinc free insulin crystals for use in pulmonary compositions
DE19903125B4 (en) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Process for drying crystals of insulin or insulin analogues

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