PT1185548E - PROCESS FOR DRYING PROTEIN CRYSTALS - Google Patents

PROCESS FOR DRYING PROTEIN CRYSTALS

Info

Publication number
PT1185548E
PT1185548E PT00903580T PT00903580T PT1185548E PT 1185548 E PT1185548 E PT 1185548E PT 00903580 T PT00903580 T PT 00903580T PT 00903580 T PT00903580 T PT 00903580T PT 1185548 E PT1185548 E PT 1185548E
Authority
PT
Portugal
Prior art keywords
drying
water
crystal suspension
protein
protein crystal
Prior art date
Application number
PT00903580T
Other languages
Portuguese (pt)
Inventor
Deusser Rolf
Kraemer Peter
Thurow Horst
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of PT1185548E publication Critical patent/PT1185548E/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/30—Extraction; Separation; Purification by precipitation
    • C07K1/306—Extraction; Separation; Purification by precipitation by crystallization
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • C30B29/58—Macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B33/00—After-treatment of single crystals or homogeneous polycrystalline material with defined structure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Drying Of Solid Materials (AREA)
  • Extraction Or Liquid Replacement (AREA)

Abstract

The present invention relates to a process for drying protein crystals starting from an aqueous protein crystal suspension, which comprises drying the protein crystal suspension in a centrifugal dryer, where the protein crystals, after they have been filtered off from the protein crystal suspension, are brought into contact with a drying medium which consists of a mixture of water and a nonaqueous solvent which is miscible with water in any ratio and which has a lower vapor pressure than water. In the process, a drying gas which has been moistened with water is advantageously used. The protein crystal suspension is advantageously converted into a fluidized bed for the purpose of drying.
PT00903580T 1999-01-27 2000-01-15 PROCESS FOR DRYING PROTEIN CRYSTALS PT1185548E (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19903125A DE19903125B4 (en) 1999-01-27 1999-01-27 Process for drying crystals of insulin or insulin analogues

Publications (1)

Publication Number Publication Date
PT1185548E true PT1185548E (en) 2006-06-30

Family

ID=7895502

Family Applications (1)

Application Number Title Priority Date Filing Date
PT00903580T PT1185548E (en) 1999-01-27 2000-01-15 PROCESS FOR DRYING PROTEIN CRYSTALS

Country Status (20)

Country Link
US (1) US6408536B1 (en)
EP (1) EP1185548B1 (en)
JP (1) JP4465120B2 (en)
KR (1) KR100652471B1 (en)
CN (1) CN1211397C (en)
AT (1) ATE323101T1 (en)
AU (1) AU764353B2 (en)
BR (1) BRPI0007713B8 (en)
CA (1) CA2361397C (en)
CY (1) CY1105256T1 (en)
CZ (1) CZ300915B6 (en)
DE (2) DE19903125B4 (en)
DK (1) DK1185548T3 (en)
ES (1) ES2259994T3 (en)
HK (1) HK1044548B (en)
HU (1) HU226697B1 (en)
PL (1) PL197694B1 (en)
PT (1) PT1185548E (en)
RU (1) RU2235730C2 (en)
WO (1) WO2000044767A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19903125B4 (en) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Process for drying crystals of insulin or insulin analogues
GB0219815D0 (en) * 2002-08-24 2002-10-02 Accentus Plc Preparation of small crystals
DE102004049241A1 (en) * 2004-10-09 2006-04-20 Sanofi-Aventis Deutschland Gmbh Dryers and method for controlling a dryer
EP1870649A1 (en) * 2006-06-20 2007-12-26 Octapharma AG Lyophilisation targetting defined residual moisture by limited desorption energy levels
US20090271021A1 (en) * 2008-04-28 2009-10-29 Popp Shane M Execution system for the monitoring and execution of insulin manufacture
SG11201401646SA (en) 2011-11-16 2014-10-30 Bayer Ip Gmbh Device for filtration, drying and storage
JP7213254B2 (en) * 2017-09-26 2023-01-26 バイオコン バイオロジックス インディア リミテッド Integrated and automated filtration for separation, washing and drying of peptide crystals

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139637A (en) * 1972-12-28 1979-02-13 Maurice Rouchy Quinone derivatives useful as medicaments
US4133716A (en) * 1976-11-22 1979-01-09 Crc Compagnia Ricerca Chimca, S.A. Method for the biosynthesis of a microbial insecticide
US5234503A (en) * 1987-02-02 1993-08-10 A.E. Saley Manufacturing Co. Integrated process for producing crystalline fructose and a high-fructose, liquid-phase sweetener
DE3717370A1 (en) * 1987-05-22 1988-12-01 Hoechst Ag MIXED CRYSTALS FROM INSULIN AND INSULINE DERIVATIVES, METHOD FOR THE PRODUCTION OF THESE MIXED CRYSTALS, PHARMACEUTICAL AGENTS CONTAINING THESE MIXED CRYSTALS AND THEIR USE FOR TREATING DIABETES MELLITUS
DE4013388A1 (en) * 1990-04-26 1991-10-31 Titus Hans Joachim CENTRIFUGAL DRYER
US5526581A (en) * 1992-10-30 1996-06-18 Philip Morris Incorporated Process for adjusting the moisture content of organic materials
DK0622376T3 (en) * 1993-04-27 2001-11-12 Hoechst Ag Amorphous monospheric forms of insulin derivatives
US5597893A (en) * 1994-10-31 1997-01-28 Eli Lilly And Company Preparation of stable insulin analog crystals
US5544425A (en) * 1995-05-17 1996-08-13 Mallinckrodt Medical, Inc. Aggressive convective drying in a nutsche type filter/dryer
GB9522302D0 (en) * 1995-10-31 1996-01-03 Univ Liverpool Growth promoters
US5932212A (en) * 1996-05-24 1999-08-03 Altus Biologics, Inc. Crosslinked protein crystal formulations and their use as catalysts in organic solvents
US5743840A (en) * 1996-06-24 1998-04-28 Carr Separations, Inc. Centrifuge with a heating jacket for drying collected solids
IL131796A0 (en) * 1997-03-20 2001-03-19 Novo Nordisk As Zinc free insulin crystals for use in pulmonary compositions
DE19903125B4 (en) * 1999-01-27 2006-01-05 Sanofi-Aventis Deutschland Gmbh Process for drying crystals of insulin or insulin analogues

Also Published As

Publication number Publication date
HU226697B1 (en) 2009-07-28
JP2002535415A (en) 2002-10-22
PL197694B1 (en) 2008-04-30
BR0007713A (en) 2001-11-27
AU2541800A (en) 2000-08-18
BRPI0007713B1 (en) 2016-06-14
CA2361397A1 (en) 2000-08-03
EP1185548A2 (en) 2002-03-13
EP1185548B1 (en) 2006-04-12
CN1211397C (en) 2005-07-20
ES2259994T3 (en) 2006-11-01
HK1044548B (en) 2006-01-20
HUP0105427A3 (en) 2003-12-29
PL350169A1 (en) 2002-11-18
WO2000044767A2 (en) 2000-08-03
HK1044548A1 (en) 2002-10-25
US6408536B1 (en) 2002-06-25
CZ20012630A3 (en) 2001-10-17
RU2235730C2 (en) 2004-09-10
CY1105256T1 (en) 2010-03-03
KR20010090012A (en) 2001-10-17
JP4465120B2 (en) 2010-05-19
KR100652471B1 (en) 2006-12-01
DE19903125B4 (en) 2006-01-05
CN1344273A (en) 2002-04-10
WO2000044767A3 (en) 2001-11-08
CA2361397C (en) 2010-02-23
ATE323101T1 (en) 2006-04-15
DE19903125A1 (en) 2000-08-10
CZ300915B6 (en) 2009-09-09
BRPI0007713B8 (en) 2021-05-25
AU764353B2 (en) 2003-08-14
DK1185548T3 (en) 2006-08-14
DE50012577D1 (en) 2006-05-24
HUP0105427A2 (en) 2002-04-29

Similar Documents

Publication Publication Date Title
RU95102329A (en) Process and stabilized catalyst system for preparation of olefins
DE50113004D1 (en) PROCESS FOR THE PREPARATION OF SALPETIC ACID
BRPI0211258B8 (en) method for preparing a substantially cross-linked gelatin powder, composition, and kit
DE69807650T2 (en) REMOVAL OF BINDING AGENT
MX9304736A (en) SYSTEM AND METHOD FOR REMOVING HYDROCARBONS FROM GASEOUS MIXTURES.
PT1185548E (en) PROCESS FOR DRYING PROTEIN CRYSTALS
BR0104896A (en) Process for urea synthesis
ID25588A (en) PROCESS FOR DEHIDRATING GAS CONTAINED FLUID DRYING MATERIALS, WITH HIGH REGENERATION EFFICIENCY OF SUCH DRYING MATERIALS
NO20035231L (en) Peptides that can be used to treat tumors and other conditions that require the removal or destruction of cells
DE60013021D1 (en) Production of S, S and R, S amino acid isosteres
EP1156033A4 (en) Process for producing acidic n-(long-chain acyl)amino acid
DE69719850T2 (en) Process for the production of melamine
AU6924501A (en) Method for isolating and purifying a protein and resulting protein
BR9808918A (en) Process for the preparation of alkaline solutions containing aromatic polymers
RU2001123684A (en) METHOD OF DRYING CRYSTALS OF PROTEINS
MY139306A (en) Purification of titania
JP2002535415A5 (en)
PT893999E (en) PRODUCTION PROCESS FOR THE PRODUCTION OF PREPARATIONS OF EFONIDIPINE CHLORIDRATE
NO20001040L (en) Drying medium with reduced surface energy and limiting opening, process for its production, and process for the production of paper
KR840004121A (en) Stabilization Method of Azrene Derivatives
BR9813185A (en) Process for removing mycotoxins from a shipment of green coffee
RU94027073A (en) Method of preparing bisulfite magnesium base cooking liquor for cellulose production
RU94042509A (en) Method of preparing gas
Sundaram Enzyme Engineering—Then and Now
DE69622372T2 (en) Protein purification