RU2000108535A - METHOD FOR PRODUCING 3-PHENYL-4-AMINOBACRYLIC ACID DERIVATIVES (PHENIBUT, CARPHEDON AND MEFIBUT MEDICINES) - Google Patents
METHOD FOR PRODUCING 3-PHENYL-4-AMINOBACRYLIC ACID DERIVATIVES (PHENIBUT, CARPHEDON AND MEFIBUT MEDICINES)Info
- Publication number
- RU2000108535A RU2000108535A RU2000108535/04A RU2000108535A RU2000108535A RU 2000108535 A RU2000108535 A RU 2000108535A RU 2000108535/04 A RU2000108535/04 A RU 2000108535/04A RU 2000108535 A RU2000108535 A RU 2000108535A RU 2000108535 A RU2000108535 A RU 2000108535A
- Authority
- RU
- Russia
- Prior art keywords
- carried out
- sodium
- acid
- catalysts
- mefibut
- Prior art date
Links
- DAFOCGYVTAOKAJ-UHFFFAOYSA-N Phenibut Chemical compound OC(=O)CC(CN)C1=CC=CC=C1 DAFOCGYVTAOKAJ-UHFFFAOYSA-N 0.000 title claims 3
- 239000003814 drug Substances 0.000 title claims 2
- 229960004122 phenibut Drugs 0.000 title claims 2
- LYONXVJRBWWGQO-UHFFFAOYSA-N 2-(2-oxo-4-phenylpyrrolidin-1-yl)acetamide Chemical compound C1C(=O)N(CC(=O)N)CC1C1=CC=CC=C1 LYONXVJRBWWGQO-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000003054 catalyst Substances 0.000 claims 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- 238000005984 hydrogenation reaction Methods 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N iso-propanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N HCl Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- LYGJENNIWJXYER-UHFFFAOYSA-N Nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 2
- 230000020477 pH reduction Effects 0.000 claims 2
- KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims 2
- KXTAOXNYQGASTA-UHFFFAOYSA-N 2-benzylidenepropanedioic acid Chemical compound OC(=O)C(C(O)=O)=CC1=CC=CC=C1 KXTAOXNYQGASTA-UHFFFAOYSA-N 0.000 claims 1
- YXFFBHDBSVRNGH-UHFFFAOYSA-N 2-ethoxycarbonyl-4-nitro-3-phenylbutanoic acid Chemical compound CCOC(=O)C(C(O)=O)C(C[N+]([O-])=O)C1=CC=CC=C1 YXFFBHDBSVRNGH-UHFFFAOYSA-N 0.000 claims 1
- GWYFCOCPABKNJV-UHFFFAOYSA-N 3-Methylbutanoic acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 claims 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N Sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 claims 1
- 238000005903 acid hydrolysis reaction Methods 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000006243 chemical reaction Methods 0.000 claims 1
- VUWPIBNKJSEYIN-UHFFFAOYSA-N diethyl 2-benzylidenepropanedioate Chemical compound CCOC(=O)C(C(=O)OCC)=CC1=CC=CC=C1 VUWPIBNKJSEYIN-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 125000004494 ethyl ester group Chemical group 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- -1 isopropyl alcohols Chemical class 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 229910052697 platinum Inorganic materials 0.000 claims 1
- 238000000746 purification Methods 0.000 claims 1
- 150000004040 pyrrolidinones Chemical class 0.000 claims 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 159000000000 sodium salts Chemical class 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002194 synthesizing Effects 0.000 claims 1
Claims (4)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2000108535/04A RU2190595C2 (en) | 2000-04-05 | 2000-04-05 | Method of synthesis if derivatives of 3-phenyl-4-aminobutanoic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RU2000108535/04A RU2190595C2 (en) | 2000-04-05 | 2000-04-05 | Method of synthesis if derivatives of 3-phenyl-4-aminobutanoic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2000108535A true RU2000108535A (en) | 2002-03-20 |
RU2190595C2 RU2190595C2 (en) | 2002-10-10 |
Family
ID=20232895
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2000108535/04A RU2190595C2 (en) | 2000-04-05 | 2000-04-05 | Method of synthesis if derivatives of 3-phenyl-4-aminobutanoic acid |
Country Status (1)
Country | Link |
---|---|
RU (1) | RU2190595C2 (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111393312A (en) * | 2020-03-11 | 2020-07-10 | 福建科宏生物工程股份有限公司 | Preparation method for synthesizing 4-amino-3-phenylbutyric acid hydrochloride by one-pot method and product prepared by same |
-
2000
- 2000-04-05 RU RU2000108535/04A patent/RU2190595C2/en not_active IP Right Cessation
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