RU2000107662A - STABLE WATER SOLUTION EM 12 - Google Patents

STABLE WATER SOLUTION EM 12

Info

Publication number
RU2000107662A
RU2000107662A RU2000107662/14A RU2000107662A RU2000107662A RU 2000107662 A RU2000107662 A RU 2000107662A RU 2000107662/14 A RU2000107662/14 A RU 2000107662/14A RU 2000107662 A RU2000107662 A RU 2000107662A RU 2000107662 A RU2000107662 A RU 2000107662A
Authority
RU
Russia
Prior art keywords
water solution
stable water
stable aqueous
aqueous solution
solution according
Prior art date
Application number
RU2000107662/14A
Other languages
Russian (ru)
Other versions
RU2238727C2 (en
Inventor
ГЕРМАНН Тино
КУГЕЛЬМАНН Генрих
Original Assignee
Грюненталь Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19914621A external-priority patent/DE19914621C2/en
Application filed by Грюненталь Гмбх filed Critical Грюненталь Гмбх
Publication of RU2000107662A publication Critical patent/RU2000107662A/en
Application granted granted Critical
Publication of RU2238727C2 publication Critical patent/RU2238727C2/en

Links

Claims (3)

1. Стабильный водный раствор согласно заявке DE 19743968.3, содержащий ЕМ 12, для парентерального введения, при этом ЕМ 12 растворен в изотоническом растворе глюкозы и значение рН раствора меньше или равно 5,5.1. A stable aqueous solution according to the application DE 19743968.3 containing EM 12 for parenteral administration, wherein EM 12 is dissolved in an isotonic glucose solution and the pH value of the solution is less than or equal to 5.5. 2. Стабильный водный раствор по п.1, отличающийся тем, что он содержит активное вещество в количестве по меньшей мере 0,2 мг/мл. 2. The stable aqueous solution according to claim 1, characterized in that it contains the active substance in an amount of at least 0.2 mg / ml. 3. Способ получения стабильного водного раствора по п.1, отличающийся тем, что ЕМ 12 добавляют в изотонический раствор глюкозы при значении рН последнего 4-5 и эту смесь встряхивают до достижения полного растворения активного вещества и/или для сокращения продолжительности процесса приготовления обрабатывают затем ультразвуком и фильтруют в антисептических условиях. 3. The method of obtaining a stable aqueous solution according to claim 1, characterized in that EM 12 is added to the isotonic glucose solution at a pH of 4-5 and this mixture is shaken until the active substance is completely dissolved and / or processed then sonicated and filtered under antiseptic conditions.
RU2000107662A 1999-03-31 2000-03-30 Stable aqueous solution em12 RU2238727C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19914621.7 1999-03-31
DE19914621A DE19914621C2 (en) 1997-10-06 1999-03-31 Stable aqueous solution from EM 12

Publications (2)

Publication Number Publication Date
RU2000107662A true RU2000107662A (en) 2001-12-27
RU2238727C2 RU2238727C2 (en) 2004-10-27

Family

ID=7903088

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2000107662A RU2238727C2 (en) 1999-03-31 2000-03-30 Stable aqueous solution em12

Country Status (26)

Country Link
US (1) US6306879B1 (en)
EP (1) EP1040838B1 (en)
JP (1) JP2000290180A (en)
KR (1) KR20010006930A (en)
CN (1) CN1270027A (en)
AR (1) AR023199A1 (en)
AT (1) ATE235256T1 (en)
AU (1) AU766250B2 (en)
BR (1) BR0001112A (en)
CA (1) CA2302886A1 (en)
CO (1) CO4970704A1 (en)
DE (1) DE50001522D1 (en)
DK (1) DK1040838T3 (en)
ES (1) ES2194640T3 (en)
HK (1) HK1033645A1 (en)
HU (1) HUP0001312A2 (en)
IL (1) IL135340A0 (en)
NO (1) NO20001658L (en)
NZ (1) NZ503428A (en)
PE (1) PE20001597A1 (en)
PL (1) PL339336A1 (en)
PT (1) PT1040838E (en)
RU (1) RU2238727C2 (en)
SI (1) SI1040838T1 (en)
SK (1) SK4632000A3 (en)
ZA (1) ZA200001618B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7268148B2 (en) * 1999-05-20 2007-09-11 Regents Of The University Of Michigan Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes
DE19957342A1 (en) * 1999-11-29 2001-05-31 Gruenenthal Gmbh Treatment of interleukin (IL)-12 mediated illnesses comprises simultaneous administration of thalidomide or analogue and antiinflammatory cytokine
WO2002068414A2 (en) 2001-02-27 2002-09-06 The Governement Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Analogs of thalidomide as potential angiogenesis inhibitors
US20030021816A1 (en) * 2001-06-06 2003-01-30 Sewon Kang Compositions and methods for use against acne-induced inflammation and dermal matrix-degrading enzymes
PT1423115E (en) * 2001-08-06 2009-07-21 Childrens Medical Center Antiangiogenic activity of nitrogen substituted thalidomide analogs
US8952895B2 (en) 2011-06-03 2015-02-10 Apple Inc. Motion-based device operations
EP1663223B1 (en) 2003-09-17 2014-01-01 The Government of the United States of America, as represented by the Secretary of the Department of Health and Human Services Thalidomide analogs as tnf-alpha modulators
US8927725B2 (en) 2011-12-02 2015-01-06 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Thio compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE146787T1 (en) 1991-04-17 1997-01-15 Gruenenthal Gmbh NEW THALIDOMIDE DERIVATIVES, A PROCESS FOR THEIR PRODUCTION AND THE USE OF THE SAME IN MEDICINAL PRODUCTS
US5629327A (en) * 1993-03-01 1997-05-13 Childrens Hospital Medical Center Corp. Methods and compositions for inhibition of angiogenesis
DE19743968C2 (en) 1997-10-06 2002-07-11 Gruenenthal Gmbh Intravenous application form of thalidomide for the therapy of immunological diseases

Similar Documents

Publication Publication Date Title
CA2382098A1 (en) Sustained-release, oral pharmaceutical forms of administration
RU2002106399A (en) MOXIFLOXACIN COMPOSITIONS CONTAINING SODIUM SALT
RU2000107662A (en) STABLE WATER SOLUTION EM 12
RU2002103315A (en) Ophthalmic composition containing ketotifen
RU2004124063A (en) CIGARETTE AND CIGAR FILTER
RU2006120946A (en) COMPOSITION OF PREGABALIN
CA2326840A1 (en) Carvedilol-galenics
WO2006025051A3 (en) Process of preparing a crystalline azithromycin monohydrate
FR2361401A1 (en) PROCESS FOR PREPARING SODIUM AMOXYCILLIN
RU97108965A (en) CONTAINING THROMBINE INHIBITOR STORAGE STABLE WATER INFUSION FOR STORAGE
RU2000129666A (en) STABLE MITOXANTRON SOLUTIONS
CA2270004A1 (en) Stable mitoxantrone solutions
RU2005111547A (en) CIGAR FILTER
EA200000772A1 (en) PHARMACEUTICAL COMPOSITIONS AND METHODS OF THEIR PREPARATION
RU97107351A (en) WATER SUSPENSION OF SABELUZOL FOR ORAL USE AND METHOD FOR PRODUCING IT
JP2000354856A5 (en)
JPH0358710B2 (en)
RU2001104352A (en) PHARMACEUTICAL COMPOSITION WITH ANTITUMOR ACTIVITY BASED ON CARBOPLATIN
RU2222548C2 (en) Application of cellulose derivative and gossypol aqueous solution as radioprotector, anti-infective, and potentiating agent, method for preparation thereof, and pharmaceutical composition based thereon
BE898082A (en) SOLUTION FOR INJECTION AND PROCESS FOR ITS PREPARATION.
RU96109524A (en) COMPOSITION - MEDICINAL FORM OF ANTI-ARTISTIC MEANS OF GLUCOSAMINE HYDROCHLORIDE FOR INJECTION
RU97119262A (en) METHOD FOR IMPROVING WINTERS OF BEE FAMILIES
Khan et al. Renal proximal tubular injury and crystallization of calcium oxalate in rat urine
RU99123856A (en) COMPOSITION FOR TREATMENT OF HIGH-TEMPERATURE OIL WELLS
RU2190411C2 (en) Injectional form of preparation of antiischemic activity