RU2000101826A - CRYSTAL MACROLIDES AND METHOD FOR THEIR PRODUCTION - Google Patents

CRYSTAL MACROLIDES AND METHOD FOR THEIR PRODUCTION

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Publication number
RU2000101826A
RU2000101826A RU2000101826/04A RU2000101826A RU2000101826A RU 2000101826 A RU2000101826 A RU 2000101826A RU 2000101826/04 A RU2000101826/04 A RU 2000101826/04A RU 2000101826 A RU2000101826 A RU 2000101826A RU 2000101826 A RU2000101826 A RU 2000101826A
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RU
Russia
Prior art keywords
compound according
compound
crystalline
formula
paragraphs
Prior art date
Application number
RU2000101826/04A
Other languages
Russian (ru)
Other versions
RU2219181C2 (en
Inventor
Корнелиа ДОЗЕНБАХ
Максимилиан ГРАССБЕРГЕР
Отто ХАРТМАНН
Амарилла ХОРВАТ
Жан-Поль МУТС
Герхард ПЕНН
Забине ПФЕФФЕР
Дирк ВИККХУЗЕН
Original Assignee
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from GBGB9713730.1A external-priority patent/GB9713730D0/en
Application filed by Новартис Аг filed Critical Новартис Аг
Publication of RU2000101826A publication Critical patent/RU2000101826A/en
Application granted granted Critical
Publication of RU2219181C2 publication Critical patent/RU2219181C2/en

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Claims (9)

1. Соединение формулы I
Figure 00000001

или его таутомер либо сольват в каждом случае в кристаллической форме.1. The compound of formula I
Figure 00000001

or its tautomer or solvate in each case in crystalline form. 2. Соединение по п.1 в кристаллической форме А. 2. The compound according to claim 1 in crystalline form A. 3. Соединение по п.1 в кристаллической форме Б. 3. The compound according to claim 1 in crystalline form B. 4. Способ получения кристаллического соединения по п.1, включающий соответствующее превращение аморфного соединения формулы I из его раствора в индуцирующих кристаллизацию условиях. 4. A method of obtaining a crystalline compound according to claim 1, comprising the appropriate conversion of an amorphous compound of formula I from its solution to crystallization-inducing conditions. 5. Способ по п.4 получения кристаллического соединения по п.2, включающий соответствующее превращение соединения формулы I, находящегося в форме, отличной от формы А, или его таутомерной или сольватированной формы из его раствора в условиях, индуцирующих кристаллизацию преимущественно формы А. 5. The method according to claim 4 of obtaining a crystalline compound according to claim 2, comprising the appropriate conversion of a compound of formula I, which is in a form other than form A, or its tautomeric or solvated form from its solution under conditions that induce crystallization of predominantly Form A. 6. Способ по п.4 получения кристаллического соединения по п.3, включающий соответствующее превращение соединения формулы I, находящегося в форме, отличной от формы Б, или его таутомерией или сольватированной формы из его раствора в условиях, индуцирующих кристаллизацию преимущественно формы Б. 6. The method according to claim 4 of obtaining a crystalline compound according to claim 3, including the corresponding conversion of the compound of formula I, which is in a form other than form B, or its tautomerism or the solvated form from its solution under conditions that induce crystallization of predominantly form B. 7. Фармацевтическая композиция, включающая соединение по любому из пп.1 - 3 или полученная из него. 7. Pharmaceutical composition comprising a compound according to any one of claims 1 to 3 or derived from it. 8. Соединение по любому из пп.1 - 3, предназначенное для применения в качестве лекарственного средства или для применения при изготовлении лекарственного средства. 8. The compound according to any one of paragraphs.1 to 3, intended for use as a medicine or for use in the manufacture of a medicine. 9. Соединение по любому из пп.1 - 3, полученное способом по любому из пп.4 - 6. 9. The compound according to any one of paragraphs.1 to 3, obtained by the method according to any one of paragraphs.4 to 6.
RU2000101826/04A 1997-06-30 1998-06-26 Crystalline macrolides, methods for their preparing and pharmaceutical composition based on thereof RU2219181C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9713730.1 1997-06-30
GBGB9713730.1A GB9713730D0 (en) 1997-06-30 1997-06-30 Organic compounds

Publications (2)

Publication Number Publication Date
RU2000101826A true RU2000101826A (en) 2001-09-27
RU2219181C2 RU2219181C2 (en) 2003-12-20

Family

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RU2000101826/04A RU2219181C2 (en) 1997-06-30 1998-06-26 Crystalline macrolides, methods for their preparing and pharmaceutical composition based on thereof

Country Status (32)

Country Link
US (1) US6423722B1 (en)
EP (1) EP0994880B1 (en)
JP (2) JP3880634B2 (en)
KR (1) KR100399765B1 (en)
CN (1) CN1139595C (en)
AR (1) AR017754A1 (en)
AT (1) ATE287410T1 (en)
AU (1) AU739211B2 (en)
BR (1) BR9810956A (en)
CA (1) CA2290412C (en)
CO (1) CO4940463A1 (en)
CZ (1) CZ297244B6 (en)
DE (1) DE69828692T2 (en)
DK (1) DK0994880T3 (en)
ES (1) ES2236922T3 (en)
GB (1) GB9713730D0 (en)
HK (1) HK1028597A1 (en)
HU (1) HU227755B1 (en)
ID (1) ID24897A (en)
IL (1) IL132761A0 (en)
MY (1) MY118718A (en)
NO (1) NO312765B1 (en)
NZ (1) NZ500994A (en)
PE (1) PE97699A1 (en)
PL (1) PL192761B1 (en)
PT (1) PT994880E (en)
RU (1) RU2219181C2 (en)
SK (1) SK285665B6 (en)
TR (1) TR199903189T2 (en)
TW (1) TW552264B (en)
WO (1) WO1999001458A1 (en)
ZA (1) ZA985655B (en)

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EP1817315A1 (en) * 2004-12-01 2007-08-15 Teva Gyógyszergyár Zártköruen Muködo Részvenytarsaság Processes for producing crystalline macrolides
US20090082386A1 (en) * 2006-11-06 2009-03-26 Erzsebet Meszarosne Sos Ascomycin and pimecrolimus having reduced levels of desmethylascomycin and 32-deoxy-32-epichloro-desmethylascomycin respectively, and methods for preparation thereof
US20100105724A1 (en) * 2006-12-07 2010-04-29 Helsinn Healthcare Sa Crystalline and amorphous forms of palonosetron hydrochloride
US9192697B2 (en) 2007-07-03 2015-11-24 Hemoteq Ag Balloon catheter for treating stenosis of body passages and for preventing threatening restenosis
EP3064230B1 (en) 2009-07-10 2019-04-10 Boston Scientific Scimed, Inc. Use of nanocrystals for a drug delivery balloon
WO2011008393A2 (en) 2009-07-17 2011-01-20 Boston Scientific Scimed, Inc. Nucleation of drug delivery balloons to provide improved crystal size and density
US8889211B2 (en) 2010-09-02 2014-11-18 Boston Scientific Scimed, Inc. Coating process for drug delivery balloons using heat-induced rewrap memory
US8669360B2 (en) * 2011-08-05 2014-03-11 Boston Scientific Scimed, Inc. Methods of converting amorphous drug substance into crystalline form
US9056152B2 (en) 2011-08-25 2015-06-16 Boston Scientific Scimed, Inc. Medical device with crystalline drug coating
SG11201507406YA (en) 2013-03-15 2015-10-29 Biosensors Int Group Ltd Purification of rapamycin derivatives
EP3178824A1 (en) 2015-12-08 2017-06-14 Medichem, S.A. Process for preparing pimecrolimus
WO2018202733A1 (en) * 2017-05-01 2018-11-08 Meda Pharma Gmbh & Co. Kg Process to convert crude ascomycin into purified pimecrolimus
EP3741367A1 (en) 2019-05-21 2020-11-25 Premark Pharma GmbH Treatment of ocular disease

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US4127647A (en) * 1975-04-08 1978-11-28 Meiji Seika Kaisha, Ltd. Process for preparation of stable amorphous macrolide antibiotic solids
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JP2728482B2 (en) * 1989-01-26 1998-03-18 協和醗酵工業株式会社 Purification of macrolide antibiotics
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GB9713730D0 (en) * 1997-06-30 1997-09-03 Ciba Geigy Ag Organic compounds

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