RU1771745C - Method of septicopyemia treatment - Google Patents

Abstract

Usage: in obstetric and gynecological practice. Goal 1: reduction of mortality and reduction of treatment time. The essence of the method: against the background of complex drug therapy, fibrinolytic and lubricant drugs are dripped into the abdominal aorta through a catheter for 8-12 hours, then 3-4 times daily from the 2nd day. a complex of drugs and a donor suspension of 40-50 ml are administered through a catheter for 6-12 days, with a simultaneous compression of the femoral artery for 20-30 minutes per course of 100-300 ml. Positive effect: the proposed method for the treatment of septicolemia made it possible to reduce lethality by 7 times, the duration of treatment by an average of 9-10 days, and to maintain reproductive function in a number of patients.

Description

The invention relates to medicine, namely to obstetrics and gynecology.

The aim of the invention is to reduce mortality and treatment time.

The method is carried out as follows.

0.5–0.75 million units are administered dropwise via a Seldinger catheter inserted through the femoral artery to the level of aortic bifurcation over a period of 8–12 hours. streptoliasis with 4-6 ml of a 2% solution of papaverine in 1.2-2.0 l of physiological saline without constricting the femoral arteries, which ensures restoration of blood flow in part of the thrombosed and spasmodic vessels of the outbreak. Subsequently, for 6-12 days, 3-4 sessions of intra-aortic infusions lasting 20-30 minutes with finger pressing of the femoral arteries in the upper third of the thighs are performed (for

increased drug delivery to the pool of the internal iliac arteries). During each session, 100-130 ml of reopoliglucin with 0.5-0.3 ml of compliment and a mixture of 1 / 3-1 / 4 of the daily dose of several antibiotics selected in accordance with the sensitivity of microflora pus, 0.6-1. 0 ml of a 2% solution of papaverine, 20-60 ml of a 0.5% solution of trimecaine, 1000-1250 units of heparin in 300-400 ml of physiological saline, as well as once a day 3-6 times per course of 50 ml of donor white suspension . The water suspension was prepared from healthy donors by plasmacytheresis in a polymer apparatus and, on the day of preparation, after determination of ABO and pH compatibility, it was poured into the aorta. One dose of leukoprecipitate (50 ml) contained 1 109 leukocytes. The course required 150-300 ml of white suspension (3 108 - b 109 cells).

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Example 1. Patient 3., 18 years old, suffered a traumatic birth by twins, The immediate postpartum period was complicated by septic endomyometritis, metro thrombophlebitis, thrombophlebitis of the deep veins of the pelvis and lower extremities, and acute bilateral abscessed pneumonia. Septicopyemi.

Comprehensive treatment (antisepsis) has begun. A catheter was inserted through the left femoral artery until bifurcation of the abdominal aorta. On the same day, 0.5 million units were introduced into the aorta over 8 hours. streptoliasis with 4 ml of a 2% solution of papaverine in 1.6 l of physiological saline. Then from the 2nd day for 6 days, 130 ml of reopoliglucin with 0.3 ml of compliment, as well as 1.5 g of kefzol, 2 g of ampiox, 0.6 ml were injected into the catheter 3 times a day with finger squeezing of the femoral arteries 2% papaverine solution, 6 ml of a 0.5% solution of trimecaine, 1000 units of heparin in 300 ml of physiological saline, and an additional 50 ml of donor white suspension (150 ml (3 -U9 cells) per course) was added. A pronounced positive clinical effect was obtained. After two days, the body temperature returned to normal, purulent discharge from the vagina stopped, the size of the uterus began to decrease, shortness of breath decreased. 17-11-85 g. Catheter

deleted. Red blood cells of peripheral blood 4.2-1012 / l, white blood cells - 7.6 - 109 / l, LII - 1.2 units. ESR-30 mm / h. Septic pneumonia regressed, uterus enlarged to

12-14 weeks. She continued to receive traditional antiseptic and anti-pneumonic treatment. On recovery she was discharged from the hospital. At the control examination after six months, she feels good, her genitals are normal.

The application of the proposed method in 39 women allowed to reduce mortality by 7 times, the duration of treatment by an average of 9-10 days, and the fate of patients to maintain reproductive function.

Claims (1)

The claims A method of treating septicopyemia by administering drugs, characterized in that, in order to reduce lethal outcomes and shorten treatment time, fibrinolytic and antispasmodic drugs are administered via a catheter, which is placed over the abdominal aortic bifurcation for 8-12 hours, and then with constricted femoral arteries in combination with drugs from the second day, a donor leukemia suspension in a dose of 40-50 ml is administered 3-4 times a day.