RU1508373C - Method of treatment and prophylaxis of bacterial necrotic dermatitis in minks - Google Patents

Abstract

FIELD: veterinary. SUBSTANCE: method involves administration of 0.5% hot aqueous solutions of zinc sulfate and nicotinic acid to animals (1 ml of each solution) or orally with food as: zinc sulfate 20-25 mg/kg, nicotinic acid 6-10 mg/kg mass weight. For prophylaxis zinc sulfate and nicotinic acid are added to the food at doses 10-15 and 3-5 mg/kg mass weight, respectively, for 20 days, 4 times per year. Effectivenes of method is 100%. EFFECT: enhanced effectiveness of method. 3 cl

Description

 The invention relates to veterinary medicine, and in particular to methods for treating diseases of animal limbs.

 The aim of the invention is to increase the therapeutic and prophylactic effectiveness of the method.

 PRI me R 1. In the experiment take 75 patients with necrotic dermatitis (ND) mink, divided into several groups of 15 mink.

 Scheme of experience.

 1 group of minks is injected intramuscularly into the back of the thigh at a dose of 1 ml with a 0.5% solution of zinc sulfate.

 Group 2 similarly injected with a 0.5% solution of vitamin PP.

 3 group of minks at the same time, but in different limbs, at the same doses are injected with solutions of zinc sulfate and vitamin PP.

 4 group of minks daily for 20 days include 25 mg of zinc sulfate (or 5 mg in terms of pure zinc) and 10 mg of vitamin PP in the feed.

 Group 5 - control (minks are contained in the general diet).

 Results.

 Group 1 - the full recovery of minks occurs in 24 days.

 Group 2 - similarly, but some of the minks in some places in previously affected areas still had loosened dry scab, under which there was already healthy skin.

 Group 3 - minks recover within 2-3 weeks.

 Group 4 - minks recover after 17-27 days from the start of the experiment.

 5 group - four minks fell with signs of ND due to sepsis, the rest continue to hurt.

 Thus, the most effective treatment methods were those used in groups 3 and 4.

 In an experiment for the prevention of necrotic dermatitis, minks are taken in an amount of 2330 animals, which for 18 days include 15 mg of zinc sulfate and 3 mg of vitamin PP per 1 kg of live weight per day.

 After 3 weeks, ND 10 minks became ill from them, the rest remained healthy. The incidence of ND minks in other teams considered to be successful turned out to be higher. These funds were not used here.

 We can assume that zinc sulfate in combination with vitamin PP has a therapeutic and prophylactic effect in relation to mink necrotic dermatitis.

 PRI me R 2. Disease of minks with necrotic dermatitis in the farm "Rodniki" was recorded in the autumn-winter-spring periods of the year for 6 years. The incidence rate varied between 10-15% annually. Sick animals were killed, and the animals were disinfected.

 By October 15, 1986, 15% of minks fell ill with necrotic dermatitis. For therapeutic purposes, bicillin-3 (1 group of 15 goals) was tested and the complex: zinc sulfate + vitamin PP (2 group of 15 goals). The control is the remaining sick animals, which are killed on the skin.

 Scheme of experience.

 1 group. Bicillin-3 is administered in doses of 30 thousand IE IE intramuscularly twice with an interval of 5 days.

 2 group. Ext./ muscularly twice with an interval of 7 days, 0.5% sterile solutions of zinc sulfate and vitamin PP are introduced in volumes of 1 ml into different hind limbs.

 In the first group, a quick therapeutic effect was recorded (on the 5-7th day after the last injection), however, some minks had relapses of the disease.

 In the second group, the healing process was longer (recovery 10-15 days after the last injection), but the disease recurrence was not registered.

 The whole mink population (19,500 goals) in the diet every other day includes zinc sulfate at a dose of 20 mg / kg body weight and vitamin PP (nicotinic acid) at a dose of 1 mg / kg. Within 10 days, the allocation of patients with ND minks stopped.

 These drugs were included in the diet according to this scheme until February 15, 1987. During this period, not a single sick animal was isolated.

 From February 15 to March 3, drugs were not included in the diet due to their temporary absence on the farm. Beginning in late February and March, mink necrotic dermatitis patients were isolated again (30 goals in total).

 From March 3 to April 8, 1987, the prophylactic course with these drugs was repeated in the same way. The selection of patients with ND animals was stopped.

 Based on the results obtained, it can be considered that with necrotic dermatitis of minks, in addition to antibiotics, the following complex has therapeutic efficacy: zinc sulfate + vitamin PP (with parenteral administration). The same complex, when administered orally, has pronounced prophylactic efficacy close to 100%.

Claims (3)

 1. METHOD OF TREATMENT AND PREVENTION OF BACTERIAL NECROTIC MORK DERMATITIS, including the introduction of zinc sulfate into the body of an animal, characterized in that, in order to increase efficiency, nicotinic acid is additionally administered to the animals, moreover, it is administered either by intramuscular injection with a 0.5% solution zinc sulfate and nicotinic acid, or orally with food in the form of 10 - 20% hot aqueous solutions.  2. The method according to claim 1, characterized in that for the prevention of the disease, zinc sulfate and nicotinic acid with feed are given to animals for 20 days at the rate of, respectively, 10-15 mg / kg and 3-5 mg / kg of animal weight.  3. The method according to claim 1, characterized in that for the treatment of the disease, zinc sulfate and nicotinic acid are administered either by injection at the same time at a rate of 1 ml, respectively, or with feed at a rate of 20-25 mg / kg and 6-10 mg / kg of animal weight for 20 days.