RU108972U1 - CAPSULE POWDER INHALER - Google Patents

Abstract

 1. Capsule powder inhaler, comprising a detachable case with air intakes, a cover with an aerosol outlet, a capsule chamber with pharmaceutically active substances, a capsule disruption device, a mouthpiece, characterized in that the capsule chamber is provided with two cells for capsules with different pharmaceutically active substances, the capsule destruction device is made in the form of two spring-loaded breakdown needles, actuated by buttons located on the edges of the body before inhaling the patient that formulation is provided inside the cover body grating for separating fragments capsules inlets are in the form of two channels disposed asymmetrically in opposite side walls of the housing and the mouthpiece is formed integrally with a lid. ! 2. Capsule powder inhaler according to claim 1, characterized in that the cap is rotatable in a horizontal plane relative to the housing, preferably 180 °, and is fixed in the working position. ! 3. The capsule powder inhaler according to claim 1, characterized in that the capsule cells have a different color or digital codification in accordance with the same codification of the capsule containing a specific pharmaceutically active substance. ! 4. The capsule powder inhaler according to claim 1, characterized in that the air intake channels are located at an angle to the surface of the side wall of the housing to create a helical rotation of the aerosol mixture.

Description

The proposed technical solution relates to medicine, in particular to pulmonology, and relates to a new medical device - a capsule powder inhaler, the special chamber of which has two cells for capsules, intended for the introduction of drugs into the patient’s body through the respiratory tract.

Known inhaler for the administration of drugs in the form of a powder from capsules (Application for patent of the Russian Federation No. 2008136545/14, published March 27, 2010), consisting of a detachable body with a capsule for capsules with dry powder, with at least one needle or plate opening a device for opening a capsule, a mouthpiece for inhaling powder from an open capsule, a mesh element over the capsule receiver, air intakes. This device is not intended for the simultaneous inhalation of two different powder ingredients.

In the process of systematic treatment, the need arises for the simultaneous use of capsules with various pharmaceutically active substances. This is advisable, for example, for the treatment of bronchial asthma with inhaled β ₂ -adrenomimetics in combination with systematic anti-inflammatory treatment (glucocorticosteroid). In this case, the first pharmaceutically active substance is a β ₂ -adrenoreceptor agonist: for example, formoterol (in the form of a pharmaceutically acceptable salt, fumarate). It expands the bronchi, preventing bronchospasm, is indicated for long-term maintenance therapy for bronchial asthma and the prevention of bronchospasm in reversible obstructive respiratory diseases.

The second pharmaceutically active substance is an inhaled glucocorticosteroid, which has a powerful anti-inflammatory effect and has a lower frequency of side effects than systemic glucocorticosteroids, for example, budesonide. It reduces the severity of edema of the bronchial mucosa, mucus production, sputum formation and airway hyperresponsiveness. In addition to the combination of pharmaceutically active substances formoterol-budesonide, other combinations of β ₂ -adrenoreceptor agonist and glucocorticosteroid are possible. For example, salbutamol and budesonide, formoterol and beclomethasone, salmeterol and fluticasone, etc.

To solve this problem, a device for inhalation is proposed that is used to deliver a drug, which is two dry powder mixtures with different pharmaceutically active substances, each of which is placed in a separate hard gelatin capsule. The case (1) of the device is collapsible, it has channels (7) for sucking in air (air intakes). In the lid (2), made at the same time with the mouthpiece (3), a grill (9) is provided that separates the housing (1) and the aerosol outlet (outlet 8). The device has two special cells (4, 5) for capsules with different pharmaceutical substances, as well as a piercing mechanism. Cells (4, 5) mainly have different color or digital codifications depending on the color of the capsules that are supposed to be used in it. An air duct passes through the cells (4, 5) for the capsules, connecting the holes for air intake and the outlet (8) of the aerosol. The capsule breaking device (10) is at least two oppositely spaced needles (11) connected to the springs (12) for piercing each hard gelatin capsule with powder compositions, driven by buttons (6) located along the edges of the inhaler.

When using the inhaler by turning the cap (2) through 180 °, access to the cells (4, 5) in the housing (1) is opened, capsules with pharmaceutically active substances are inserted into the corresponding cells of the device. The inhaler cover (2) is closed and the buttons of the piercing mechanism are pressed simultaneously. By pressing the buttons (6), both capsules located in the cells (4, 5) of the inhaler chamber are punctured simultaneously, after which the patient can use the drug. The inhaler is brought up with the outlet for the exit of aerosol (8) to the oral cavity, grasp the mouthpiece (3) with lips and take a full breath. Thanks to the asymmetrically arranged air inlet openings, a swirling air flow is created. Under the influence of this flow, the powder flows out of the holes in the lateral surface of the capsules and is introduced into the human respiratory system. At the same time, aggregates of powder particles are destroyed and separated from fragments of the gelatin capsule as a result of a collision with the lattice (9) separating the chamber with cells from the aerosol exit port. When installing in the chamber only one capsule with a powder mixture, its separate dosing is possible with the second cell empty.

As indicated above, the cells in the chamber of the device for inhalation can be performed mainly with color or digital coding - in accordance with the same coding of the capsule containing a specific pharmaceutically active substance. For example, a blue capsule contains a β ₂ -adrenoreceptor agonist (formoterol, terbutaline, salbutamol, salmeterol or their pharmaceutically acceptable salts of inorganic acids), it is inserted into a blue cell; and a red capsule containing an inhaled glucocorticosteroid (budesonide, beclomethasone, flunisolide, fluticasone or their pharmaceutically acceptable salts of inorganic acids) is inserted into the red cell.

The list of positions in figure 1

1. Case

2. Cover

3. Mouthpiece

4, 5. Cells for capsules

6. Buttons

7. Air Intakes

8. Outlet

9. Lattice

10. Capsule breaking device

11. Needle

12. Spring

Figure 2, 3, 4, 5 shows a view of the inhaler in different positions

Claims (4)

1. Capsule powder inhaler, comprising a detachable case with air intakes, a cover with an aerosol outlet, a capsule chamber with pharmaceutically active substances, a capsule disruption device, a mouthpiece, characterized in that the capsule chamber is provided with two cells for capsules with different pharmaceutically active substances, the capsule destruction device is made in the form of two spring-loaded breakdown needles, actuated by buttons located on the edges of the body before inhaling the patient that formulation is provided inside the cover body grating for separating fragments capsules inlets are in the form of two channels disposed asymmetrically in opposite side walls of the housing and the mouthpiece is formed integrally with a lid. 2. The capsule powder inhaler according to claim 1, characterized in that the cap is rotatable in a horizontal plane relative to the housing, preferably 180 °, and is fixed in the working position. 3. The capsule powder inhaler according to claim 1, characterized in that the capsule cells have a different color or digital codification in accordance with the same codification of the capsule containing a specific pharmaceutically active substance. 4. The capsule powder inhaler according to claim 1, characterized in that the air intake ducts are located at an angle to the surface of the side wall of the housing to create a helical rotation of the aerosol mixture.