RS52304B - Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase - Google Patents
Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylaseInfo
- Publication number
- RS52304B RS52304B RS20120165A RSP20120165A RS52304B RS 52304 B RS52304 B RS 52304B RS 20120165 A RS20120165 A RS 20120165A RS P20120165 A RSP20120165 A RS P20120165A RS 52304 B RS52304 B RS 52304B
- Authority
- RS
- Serbia
- Prior art keywords
- alkyl
- hydrogen
- 6alkyl
- amino
- alkyl amino
- Prior art date
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Jedinjenje formule (I),njegove N-oksid forme, njegove farmaceutski prihvatljive adicijske soli i njegove stereohemijske izomerne forme, naznačeno time dasvaki n je ceo broj s vrednošću 0, 1 ili 2 i kada je n jednako 0 onda je moguća diretna veza;svaki m je ceo broj s vrednošću 1 ili 2;svaki X je neovisno N ili CH;svaki Y je neovisno O, S, ili NR4; gdesvaki R4 je vodonik, C1-6alkil, C1-6alkiloksiC1-6alkil, C3-6cikloalkil,C3-6cikloalkilmetil, fenil-C1-6alkil, -C(=O)-CHR5R6 ili -S(=O)2-N(CH3)2; gde svaki R5i R6 je neovisno vodonik, amino, C1-6alkil ili aminoC1-6alkil; ikada je Y jednako NR4 i R2 je na 7-poziciji indolila onda R2 i R4 zajedno mogu da formiraju dvovaljani radikal-(CH2)2- (a-1), ili-(CH2)3- (a-2);R1 je vodonik, C1-6alkil, hidroksi C1-6alkil, C1-6alkilsulfonil, C1-6alkilkarbonil ili mono- ili di(C1-6alkil)aminosulfonil;R2 je vodonik, hidroksi, amino, halo, C1-6alkil, cijano, C2-6alkenil, polihaloC1-6alkil, nitro, fenil, C1-6alkilkarbonil, hidroksikarbonil, C1-6alkilkarbonilamino, C1-6alkiloksi, ili mono- ili di(C1-6alkil)amino;R3 je vodonik, C1-6alkil, ili C1-6alkiloksi; ikada su R2 i R3 na susednim atomima ugljenika, oba mogu da formiraju dvovaljani radikal -O-CH2-O-.Prijava sadrži još 11 patentnih zahteva.The compound of formula (I), its N-oxide form, its pharmaceutically acceptable addition salts, and its stereochemically isomeric forms, wherein n is an integer having a value of 0, 1 or 2 and when n is 0 then a diuretic bond is possible; m is an integer with value 1 or 2; each X is independently N or CH; each Y is independently O, S, or NR 4; where R4 is hydrogen, C1-6alkyl, C1-6alkyloxyC1-6alkyl, C3-6cycloalkyl, C3-6cycloalkylmethyl, phenyl-C1-6alkyl, -C (= O) -CHR5R6 or -S (= O) 2-N (CH3) 2; wherein each R 5 and R 6 is independently hydrogen, amino, C 1-6 alkyl or aminoC 1-6 alkyl; when Y is NR4 and R2 is at the 7-position of indolyl then R2 and R4 together may form a double-rolled radical- (CH2) 2- (a-1), or- (CH2) 3- (a-2); R1 is hydrogen, C 1-6 alkyl, hydroxy C 1-6 alkyl, C 1-6 alkylsulfonyl, C 1-6 alkylcarbonyl or mono- or di (C 1-6 alkyl) aminosulfonyl; R 2 is hydrogen, hydroxy, amino, halo, C 1-6 alkyl, cyano, C 2-6 alkenyl, polyhaloC 1-6 alkyl, nitro, phenyl, C 1-6 alkylcarbonyl, hydroxycarbonyl, C 1-6 alkylcarbonylamino, C 1-6 alkyloxy, or mono- or di (C 1-6 alkyl) amino; R 3 is hydrogen, C 1-6 alkyl, or C 1-6 alkyloxy; ever R2 and R3 are on adjacent carbon atoms, both of which can form a double-rolled radical -O-CH2-O-.The application contains 11 more claims.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04077172 | 2004-07-28 | ||
US59218204P | 2004-07-29 | 2004-07-29 | |
PCT/EP2005/053612 WO2006010750A1 (en) | 2004-07-28 | 2005-07-25 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
Publications (1)
Publication Number | Publication Date |
---|---|
RS52304B true RS52304B (en) | 2012-12-31 |
Family
ID=34928411
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20120165A RS52304B (en) | 2004-07-28 | 2005-07-25 | Substituted indolyl alkyl amino derivatives as novel inhibitors of histone deacetylase |
Country Status (10)
Country | Link |
---|---|
CN (1) | CN1993353B (en) |
AT (1) | ATE542812T1 (en) |
DK (1) | DK1781639T3 (en) |
ES (1) | ES2381117T3 (en) |
ME (1) | ME01444B (en) |
PT (1) | PT1781639E (en) |
RS (1) | RS52304B (en) |
SI (1) | SI1781639T1 (en) |
UA (1) | UA93352C2 (en) |
ZA (1) | ZA200700764B (en) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN107095871A (en) * | 2016-02-22 | 2017-08-29 | 中国科学院上海巴斯德研究所 | Quisinostat, a kind of new efficient antimalarial agent |
CN107721980B (en) * | 2017-08-25 | 2019-07-12 | 南京医科大学 | The weary oxygen targeted prodrug and its application of a kind of fluorouracil and Quisinosta |
CN112485233B (en) * | 2020-11-03 | 2022-08-26 | 山东师范大学 | Nano sensor for detecting deacetylase and detection method and application thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2306858T3 (en) * | 2002-03-13 | 2008-11-16 | Janssen Pharmaceutica Nv | CARBONILAMINE DERIVATIVES AS NEW INHIBITORS OF HISTONADESACETILASAS. |
-
2005
- 2005-07-25 CN CN2005800256290A patent/CN1993353B/en active Active
- 2005-07-25 SI SI200531516T patent/SI1781639T1/en unknown
- 2005-07-25 AT AT05767934T patent/ATE542812T1/en active
- 2005-07-25 ME MEP-2012-53A patent/ME01444B/en unknown
- 2005-07-25 UA UAA200614022A patent/UA93352C2/en unknown
- 2005-07-25 ES ES05767934T patent/ES2381117T3/en active Active
- 2005-07-25 RS RS20120165A patent/RS52304B/en unknown
- 2005-07-25 DK DK05767934.2T patent/DK1781639T3/en active
- 2005-07-25 PT PT05767934T patent/PT1781639E/en unknown
-
2007
- 2007-01-26 ZA ZA200700764A patent/ZA200700764B/en unknown
Also Published As
Publication number | Publication date |
---|---|
DK1781639T3 (en) | 2012-05-14 |
ME01444B (en) | 2013-12-20 |
CN1993353B (en) | 2010-12-01 |
ATE542812T1 (en) | 2012-02-15 |
ZA200700764B (en) | 2008-09-25 |
SI1781639T1 (en) | 2012-06-29 |
CN1993353A (en) | 2007-07-04 |
PT1781639E (en) | 2012-05-02 |
ES2381117T3 (en) | 2012-05-23 |
UA93352C2 (en) | 2011-02-10 |
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